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https://www.readbyqxmd.com/read/28817151/comprehensive-analysis-of-long-noncoding-rna-mrna-co-expression-patterns-in-thyroid-cancer
#1
Yaying Du, Wenfei Xia, Jinjun Zhang, Dongyi Wan, Zhifang Yang, Xingrui Li
Novel molecular-targeted treatments show great prospects for radioiodine-refractory and surgically inoperable thyroid carcinomas. While aberrations in protein-coding genes are a focus in molecular thyroid cancer medicine, the impact of oncogenes on the expression of long noncoding RNAs (lncRNAs) has been largely uncharacterized. We aimed to identify the expression patterns of lncRNAs and mRNAs in high-throughput molecular profiles of 18 papillary thyroid cancer (PTC) patients. We identified 452 mRNAs and 240 unannotated lncRNAs that were differentially expressed in PTC...
August 17, 2017: Molecular BioSystems
https://www.readbyqxmd.com/read/28815726/differential-expression-profile-analysis-of-lncrna-uca1%C3%AE-regulated-mrnas-in-bladder-cancer
#2
Yu Wang, Hong Zhang, Xu Li, Wei Chen
Urothelial carcinoma associated 1α (UCA1α) is a novel long non-coding RNA (lncRNA) that regulates bladder cancer proliferation, migration, and invasion. The target genes of UCA1α have, however, not been identified. To address this, a pCDNA3.1(+)-UCA1α over-expression vector was transfected into UM-UC-2 bladder cancer cells. Genes differentially expressed between pCDNA3.1(+)-UCA1α and pCDNA3.1(+) transfected cell were then detected by microarray and bioinformatics analysis. A total of seventy-one differentially expressed genes were identified, including fifty-two up-regulated genes and nineteen down-regulated genes...
August 16, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28815541/long-noncoding-rnas-in-cancer-and-therapeutic-potential
#3
Arun Renganathan, Emanuela Felley-Bosco
Long noncoding RNAs (lncRNAs) are the major elements of the mammalian transcriptome that is emerging as a central player controlling diverse cellular mechanisms. Most of the well-studied lncRNAs so far are found to be crucial in regulating cellular processes such as cell cycle, growth, and apoptosis that ensure homeostasis. Owing to their location and distribution in the genome, lncRNAs influence the transcription of a wide range of proteins directly or indirectly by transcriptional and posttranscriptional alterations, which opens up the "LncRNA-cancer paradigm" in a context-dependent manner, i...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28814798/genetic-polymorphisms-of-lncrna-p53-regulatory-network-genes-are-associated-with-concurrent-chemoradiotherapy-toxicities-and-efficacy-in-nasopharyngeal-carcinoma-patients
#4
Youhong Wang, Zhen Guo, Yu Zhao, Yi Jin, Liang An, Bin Wu, Zhaoqian Liu, Xiaoping Chen, Xiang Chen, Honghao Zhou, Hui Wang, Wei Zhang
The relevance of the transcription factor p53 in cancer is inarguable, and numerous lncRNAs are involved in the p53 regulatory network as either regulators or effectors, triggering a transcriptional response that causes either cell arrest or apoptosis following DNA damage in a p53-dependent manner. Despite the fact that the therapeutic response is improved in NPC, heterogeneity among people remains with regard to the susceptibility of adverse effects and the efficacy of treatments. Therefore, we analysed eight potentially functional SNPs of five genes in the lncRNA-p53 regulatory network in a discovery cohort of 505 NPC patients...
August 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28813705/the-lncrna-tug1-ezh2-axis-promotes-pancreatic-cancer-cell-proliferation-migration-and-emt-phenotype-formation-through-sponging-mir-382
#5
Liang Zhao, Hongwei Sun, Hongru Kong, Zongjing Chen, Bicheng Chen, Mengtao Zhou
BACKGROUND/AIMS: Pancreatic carcinoma (PC) is the one of the most common and malignant cancers worldwide. LncRNA taurine upregulated gene 1 (TUG1) was initially identified as a transcript upregulated by taurine, and the abnormal expression of TUG1 has been reported in many cancers. However, the biological role and molecular mechanism of TUG1 in PC still needs further investigation. METHODS: Quantitative real-time PCR (qRT-PCR) was performed to measure the expression of TUG1 in PC cell lines and tissues...
August 15, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28810936/lncrna-c2dat1-promotes-cell-proliferation-migration-and-invasion-by-targeting-mir-34a-5p-in-osteosarcoma-cells
#6
Daofu Jia, Yanping Niu, Dongling Li, Zhaorui Liu
Osteosarcoma is a highly aggressive malignant bone tumor with poor prognosis in cases. Evidence suggested that lncRNAsare deregulated in multiple cancers. In this study, we investigated the role of the lncRNA C2dat1 on the biological functions of osteosarcoma cells. The expressions of C2dat1, miR-34a-5p and Sirt1 in human osteosarcoma cells were altered by transfection with their specific vectors/shRNA, or mimic/inhibitor. Then, cell viability, migration, invasion and apoptosis were respectively assessed post-transfection...
August 15, 2017: Oncology Research
https://www.readbyqxmd.com/read/28810932/lncrna-neat1-promotes-growth-and-metastasis-of-cholangiocarcinoma-cells
#7
Cheng Zhang, Jing-Yi Li, Fu-Zhou Tian, Gang Zhao, Hai Hu, Yue-Feng Ma, Yu-Long Yang
Long non-coding RNAs (lncRNAs) are known to play important roles in cancers. However, little is known about lncRNAs incholangiocarcinoma (CCA), a cholangiocyte malignancy with poor prognosis. We investigated the role of Nuclear Paraspeckle Assembly Transcript 1 (NEAT1) lncRNA in promoting cholangiocarcinoma (CCA). qRT-PCR analysis of patient samples showed that NEAT1 expression was higher in CCA tumors than matched adjacent non-tumor tissue. NEAT1 levels were also higher in CCA cell lines than a normal biliary epithelium cell line (HIBEpic)...
August 15, 2017: Oncology Research
https://www.readbyqxmd.com/read/28810927/stat3-mediated-upregulation-of-lncrna-hoxd-as1-as-a-cerna-facilitates-liver-cancer-metastasis-by-regulating-sox4
#8
Hui Wang, Xisong Huo, Xin-Rong Yang, Jia He, Lijun Cheng, Na Wang, Xuan Deng, Haojie Jin, Ning Wang, Cun Wang, Fangyu Zhao, Jingyuan Fang, Ming Yao, Jia Fan, Wenxin Qin
BACKGROUND: Several of the thousands of human long noncoding RNAs (lncRNAs) have been functionally characterized, yet their potential involvement in hepatocellular carcinoma (HCC) remains poorly understood. METHODS: LncRNA-HOXD-AS1 was identified by microarray and validated by real-time PCR. The clinicopathological significance of HOXD-AS1 was analyzed by Kaplan-Meier method. Chromatin immunoprecipitation was conducted to examine the mechanism of HOXD-AS1 upregulation...
August 14, 2017: Molecular Cancer
https://www.readbyqxmd.com/read/28799568/association-of-long-non-coding-rna-h19-and-microrna-21-expression-with-the-biological-features-and-prognosis-of-non-small-cell-lung-cancer
#9
Y Zhou, B Sheng, Q Xia, X Guan, Y Zhang
In recent years, long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) have been shown to play important roles in tumor biological function. The aim of this study was to investigate the diagnostic and prognostic value of lncRNA H19 and miR-21 expression in non-small-cell lung cancer (NSCLC). H19 and miR-21 expression was measured in tumor tissues and corresponding non-tumor lung tissues from 200 patients by quantitative reverse transcription polymerase chain reaction. Moreover, the in vitro and in vivo effects of H19 knock out in A549 cells were investigated...
August 11, 2017: Cancer Gene Therapy
https://www.readbyqxmd.com/read/28797320/decreased-expression-of-mir-138-5p-by-lncrna-h19-in-cervical-cancer-promotes-tumor-proliferation
#10
Lei Ou, Dazhong Wang, Han Zhang, Qian Yu, Fangfang Hua
MicroRNAs (miRNAs) play important roles in the carcinogenesis of cervical cancer. However, the expression and underlying mechanisms of miRNA in cervical cancer progression remain unclear. In the present study, our data showed that the expression of miR-138-5p was significantly downregulated in cervical cancer tissues, decreased expression of miR-138-5p was correlated with advanced FIGO stage, poor differentiation, lymph nodes metastasis, and poor overall survival of cervical cancer patients. Function assays showed that overexpression of miR-138-5p reduced cervical cancer cell proliferation, arrested cell in G0/G1 phase and induced cell apoptosis in vitro...
August 10, 2017: Oncology Research
https://www.readbyqxmd.com/read/28797257/identification-of-key-lncrnas-in-colorectal-cancer-progression-based-on-associated-protein-protein-interaction-analysis
#11
Haishan Zhu, Jiajing Yu, Haifeng Zhu, Yusheng Guo, Shengjie Feng
BACKGROUND: Colorectal cancer (CRC) was one of the most commonly diagnosed malignancies. The molecular mechanisms involved in the progression of CRC remain unclear. Accumulating evidences showed that long noncoding RNAs (lncRNAs) played key roles in tumorigenesis, cancer progression, and metastasis. Therefore, we aimed to explore the roles of lncRNAs in the progression of CRC. METHODS: In this study, we aimed to identify differentially expressed lncRNAs and messenger RNAs (mRNAs) in CRC by analyzing a cohort of previously published datasets: GSE64857...
August 10, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28796922/long-non-coding-rnas-and-prostate-cancer
#12
REVIEW
Aya Misawa, Ken-Ichi Takayama, Satoshi Inoue
Long non-coding RNAs (lncRNAs) are RNA transcripts larger than 200 nucleotides that do not code for proteins whose aberrant expression has been documented in various types of cancer, including prostate cancer. The lack of appropriate sensitive and specific biomarkers for prostate cancer has led to over-diagnosis and overtreatment, making lncRNAs promising novel biomarkers as well as therapeutic targets for the disease. This review attempts to summarize the current knowledge of lncRNA expression patterns and mechanisms in prostate cancer, which contribute to carcinogenesis...
August 10, 2017: Cancer Science
https://www.readbyqxmd.com/read/28796262/long-noncoding-rna-crnde-promotes-colorectal-cancer-cell-proliferation-via-epigenetically-silencing-dusp5-cdkn1a-expression
#13
Jie Ding, Juan Li, HaiYan Wang, Yun Tian, Min Xie, XueZhi He, Hao Ji, Zhonghua Ma, Bingqing Hui, Keming Wang, Guozhong Ji
Evidence indicates that long non-coding RNAs (lncRNAs) play a critical role in the regulation of tumor cellular processes, such as proliferation, apoptosis, and metastasis. LncRNA CRNDE (Colorectal Neoplasia Differentially Expressed) is located at human chromosome 16 and has been found overexpressed in a variety of cancers including colorectal cancer (CRC). In this paper, we report that lncRNA CRNDE expression was remarkably upregulated in CRC tissues and that lncRNA CRNDE overexpression was positively correlated with advanced pathological stages and larger tumor sizes...
August 10, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28794691/biological-role-of-long-non-coding-rna-in-head-and-neck-cancers
#14
REVIEW
Tomasz Kolenda, Kacper Guglas, Marcel Ryś, Marta Bogaczyńska, Anna Teresiak, Renata Bliźniak, Izabela Łasińska, Jacek Mackiewicz, Katarzyna M Lamperska
Head and neck squamous cell carcinoma (HNSCC) are one of the worst prognosis cancers with high mortality of patients. The treatment strategy is primarily based on surgery and radiotherapy but chemotherapy is also used. Every year the knowledge concerning HNSCC biology is updated with new elements such as the recent discovered molecules - long non-coding RNAs. Long non-coding RNAs are involved in regulatory processes in the cells. It has been revealed that the expression levels of lncRNAs are disturbed in tumor cells what results in the acquisition of their specific phenotype...
September 2017: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/28792527/the-long-noncoding-rna-xiap-as1-promotes-xiap-transcription-by-xiap-as1-interacting-with-sp1-in-gastric-cancer-cells
#15
Jun Cai, Dong Wang, Zhi-Gang Bai, Jie Yin, Jun Zhang, Zhong-Tao Zhang
Long noncoding RNAs (lncRNAs) play roles in the tumorigenesis, proliferation and metastasis of tumor cells. Previous studies indicate that the transcription factor Sp1 is responsible for transcription of the XIAP gene, but it is unknown whether lncRNAs are involved in XIAP transcription. Herein, we identified a novel lncRNA, denoted as XIAP-AS1, transcribed from the first intron of the complementary strand of the XIAP gene. Using RNA FISH, cell fractionation and qRT-PCR, XIAP-AS1 was determined to be located primarily in the nucleus...
2017: PloS One
https://www.readbyqxmd.com/read/28791407/long-non-coding-rna-meg3-inhibits-cell-growth-of-gliomas-by-targeting-mir-93-and-inactivating-pi3k-akt-pathway
#16
Ling Zhang, Xin Liang, Yuxiong Li
Gliomas are the most common cancers in the brain, accompanied with high morbility, occurrence, disability and mortality. Long non-coding RNAs (lncRNAs) have been proposed as promoter or inhibitor in many cancer processes. Previous findings have indicated that lncRNA-maternally expressed gene 3 (MEG3) is involved in tumorigenesis of several cancers, including glioma. However, the underlying mechanism of MEG3 in glioma remains elusive. In our study, MEG3 was found downregulated in glioma tissues compared with normal brain tissues...
August 3, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28791380/knockdown-of-lncrna-hnf1a-as1-inhibits-oncogenic-phenotypes-in-colorectal-carcinoma
#17
Wenyi Zhu, Peipei Zhuang, Wen Song, Shiyu Duan, Qiong Xu, Man Peng, Jun Zhou
Long non-coding RNAs (lncRNAs) have been demonstrated to serve important roles in the development and progression of cancer. Recently HNF1A antisense RNA 1 (HNF1A‑AS1), a lncRNA, has been reported as exhibiting a potential oncogenic role in the development of many types of cancer. However, the expression and the role of HNF1A‑AS1 in colorectal carcinoma (CRC) remains unclear. In the present study, the role of HNF1A‑AS1 in CRC was examined for the first time and its correlation with CRC cell biological behaviors was analyzed...
August 4, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28790838/downregulation-of-lncrna-sdpr-as-is-associated-with-poor-prognosis-in-renal-cell-carcinoma
#18
Wenjun Ni, Erlin Song, Mancheng Gong, Yongxiang Li, Jie Yao, Ruihua An
Renal cell carcinoma (RCC) is a common type of kidney cancer. Normally, surgical treatment can prolong life, but only for patients with early stage tumors. However, it is difficult for early detection strategies to distinguish between benign and malignant kidney tumors. Therefore, potential biomarkers for early diagnosis and prognosis of RCC are needed. Intriguingly, mounting evidence has demonstrated that many long noncoding RNAs (lncRNAs) are strongly linked to cancers. Indeed, promising RCC-associated lncRNA biomarkers have also been identified...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28782835/identification-and-functional-analysis-of-a-potential-key-lncrna-involved-in-fat-loss-of-cancer-cachexia
#19
Huiquan Liu, Ting Zhou, Bangyan Wang, Lu Li, Dawei Ye, Shiying Yu
Cancer cachexia is a devastating, multifactorial and irreversible syndrome characterized by skeletal muscle reduction with or without fat loss. Although much attention has been focused on muscle wasting, fat loss may occur earlier and accelerate muscle wasting in cachexia. The cause of 20% of cancer related death makes it urgent to discover molecular mechanisms behind cancer cachexia. Here we applied weighted gene co-expression network analysis(WGCNA) to identify cachexia related gene modules using differentially expressed 3289 genes and 59 long non-coding RNAs based on microarray data of cachectic and non-cachectic subcutaneous adipose tissue...
August 7, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28782577/down-regulation-of-long-non-coding-rna-meg3-indicates-an-unfavorable-prognosis-in-non-small-cell-lung-cancer-evidence-from-the-geo-database
#20
Zichao Zhang, Tiantian Liu, Kai Wang, Xiao Qu, Zhaofei Pang, Shaorui Liu, Qi Liu, Jiajun Du
Long non-coding RNA (lncRNA) MEG3 (maternally expressed gene 3) is an imprinted gene that suppresses cells growth in various tumors. However, the association between MEG3 expression and prognosis in non-small cell lung cancer (NSCLC) has not been fully investigated. Seven datasets with 1144 patients were obtained from Gene Expression Omnibus (GEO) database (Affymetrix U133 Plus 2.0 platform). Association between MEG3 and other variables was tested using the chi-squared test. Kaplan-Meier survival analysis was carried out to explore the association between MEG3 expression and overall survival (OS)/progression free survival (PFS)...
August 3, 2017: Gene
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