Giuseppe Procopio, Pierangela Sepe, Melanie Claps, Sebastiano Buti, Maurizio Colecchia, Patrizia Giannatempo, Valentina Guadalupi, Luigi Mariani, Luca Lalli, Giovanni Fucà, Filippo de Braud, Elena Verzoni
Importance: Metastatic collecting duct carcinoma (mCDC) is a rare type of non-clear cell renal cell carcinoma (ncRCC) with poor prognosis and no standard treatments. Despite retrospective series that have documented the benefit of cabozantinib in ncRCC, no prospective trials have evaluated this treatment in mCDC. Objective: To determine whether cabozantinib is an active treatment in patients with mCDC. Design, Setting, and Participants: The caBozantinib in cOllectiNg ductS Renal Cell cArcInoma (BONSAI) trial was an open-label, single-arm, phase 2 clinical trial carried out between January 2018 and November 2020 at a single academic center with data cut off in September 2021 on behalf of the the Italian Network for Research in Urologic-Oncology (Meet-URO 2)...
June 1, 2022: JAMA Oncology