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https://www.readbyqxmd.com/read/29077574/monte-carlo-simulation-of-radiation-transport-and-dose-deposition-from-locally-released-gold-nanoparticles-labeled-with-111-in-177-lu-or-90-y-incorporated-into-tissue-implantable-depots
#1
Priscilla Lai, Zhongli Cai, Jean-Philippe Pignol, Eli Lechtman, Shahram Mashouf, Yijie Lu, Mitchell A Winnik, David A Jaffray, Raymond M Reilly
Permanent seed implantation (PSI) brachytherapy is a highly conformal form of radiation therapy but is challenged with dose inhomogeneity due to its utilization of low energy radiation sources. Gold nanoparticles (AuNP) conjugated with electron emitting radionuclides have recently been developed as a novel form of brachytherapy and can aid in homogenizing dose through physical distribution of radiolabeled AuNP when injected intratumorally (IT) in suspension. However, the distribution is unpredictable and precise placement of many injections would be difficult...
October 27, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29050075/-specific-cytotoxicity-of-a-novel-her2-based-chimeric-antigen-receptor-modified-t-lymphocytes-against-her2-positive-tumor-cells
#2
H J Tang, Y Q Liu, X C Bian, H L Feng, B Gu, H Sun, C X Zuo, F Y Zhou, J Liu
Objective: To construct the third generation chimeric antigen receptor based on a novel humanized anti-HER2 H1-2 scFv, and to investigate the specific cytotoxicity of H1-2 CAR modified T lymphocytes(CAR-T) against HER2(+) tumor cells. Method: The expression cassette of the third generation CAR gene and anti-HER2 H1-2 scFv were constructed and cloned into lentivirus transfer plasmid, and then the third generation H1-2 CAR was transduced into human T lymphocytes using lentivirus.Enzyme linked immunosorbent assay was used to detect the expression of cytokines IL2, and LDH release assay was used to detect the cytotoxic effect of the H1-2 CAR-T...
October 8, 2017: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/28976913/monte-carlo-simulation-of-radiation-transport-and-dose-deposition-from-locally-released-gold-nanoparticles-labeled-with-sup-111-sup-in-sup-177-sup-lu-or-sup-90-sup-y-incorporated-into-tissue-implantable-depots
#3
Priscilla Lai, Zhongli Cai, Jean-Philippe Pignol, Eli Lechtman, Shahram Mashouf, Yijie Lu, Mitchell A Winnik, David A Jaffray, Raymond M Reilly
Permanent seed implantation (PSI) brachytherapy is a highly conformal form of radiation therapy but is challenged with dose inhomogeneity due to its utilization of low energy radiation sources. Gold nanoparticles (AuNP) conjugated with electron emitting radionuclides have recently been developed as a novel form of brachytherapy and can aid in homogenizing dose through physical distribution of radiolabeled AuNP when injected intratumorally (i.t.) in suspension. However, the distribution is unpredictable and precise placement of many injections would be difficult...
October 4, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28945885/single-fraction-radiosurgery-using-conservative-doses-for-brain-metastases-durable-responses-in-select-primaries-with-limited-toxicity
#4
Michael Cummings, Paul Youn, Derek P Bergsma, Kenneth Y Usuki, Kevin Walter, Manju Sharma, Paul Okunieff, Michael C Schell, Michael T Milano
BACKGROUND: Optimal doses for single-fraction stereotactic radiosurgery (SRS) in the treatment of brain metastases are not well established. Our institution utilized conservative dosing compared to maximum-tolerated doses from the Radiation Therapy Oncology Group 90-05 Phase I study. OBJECTIVE: To report individual lesion control (LC) from conservative single-fraction doses and determine factors affecting LC. METHODS: From 2003 to 2015, patients who underwent linear accelerator-based single-fraction SRS for cerebral/cerebellar metastases and receiving at least 1 follow-up magnetic resonance imaging (MRI) were identified...
August 12, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28912146/cerenkov-activated-sticky-tag-for-in-vivo-fluorescence-imaging
#5
Sudeep Das, Katja Haedicke, Jan Grimm
A big challenge for the clinical utilization of Cerenkov luminescence (CL) imaging is its low signal intensity, which is several orders of magnitude below ambient light. Consequently, highly sensitive cameras, sufficient shielding from background light and long acquisition times are required. To alleviate this problem, we hypothesize a strategy to convert the weak CL signal into a stronger fluorescence signal by using CL-activated formation of nitrenes from azides to locally fix a fluorescent probe in tissue by the formation of a covalent bond...
September 14, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28857419/bisphosphonate-use-and-the-risk-of-breast-cancer-a-meta-analysis-of-observational-studies
#6
Ying-Ju Ou, Hui-Fen Chiu, Yun-Hong Wong, Chun-Chien Yang, Yi-Hsin Yang
PURPOSE: To summarize current evidence of the association of bisphosphonate use with breast cancer risk, we used a systematic review and meta-analysis of observational studies to explore this issue. METHODS: A comprehensive search was conducted on PubMed, EMBASE, and the Cochrane Library. Pooled relative risk (RR) estimates and 95% confidence intervals (CIs) were calculated using the random effects model. RESULTS: Bisphosphonate use was associated with a 16% lower breast cancer risk (pool RR0...
October 2017: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/28835077/-effect-of-mesenchymal-stem-cells-on-the-apoptosis-of-breast-cancer-cells-induced-by-cisplatin
#7
H T Xu, Y Zhou, W Li, H H Zhang, H Y Wu, J Yang
Objective: To investigate the effect of mesenchymal stem cells (MSCs) on apoptosis of breast cancer cell line MCF-7 induced by cisplatin (DDP), MSCs derived from breast cancer (BC-MSCs) or adjacent non-cancerous tissues (BN-MSCs) were isolated, cultured and identified. Methods: BC-MSCs and BN-MSCs were isolated and cultured by tissue adherent method. The differentiation potential of BC-MSCs was detected by osteogenic and adipogenic induction, and cell surface markers of BC-MSCs and BN-MSCs were evaluated by flow cytometry...
August 23, 2017: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/28776283/tamoxifen-therapy-benefit-for-patients-with-70-gene-signature-high-and-low-risk
#8
Laura J van 't Veer, Christina Yau, Nancy Y Yu, Christopher C Benz, Bo Nordenskjöld, Tommy Fornander, Olle Stål, Laura J Esserman, Linda Sofie Lindström
BACKGROUND: Breast cancer molecular prognostic tools that predict recurrence risk have mainly been established on endocrine-treated patients and thus are not optimal for the evaluation of benefit from endocrine therapy. The Stockholm tamoxifen (STO-3) trial which randomized postmenopausal node-negative patients to 2-year tamoxifen (followed by an optional randomization for an additional 3-year tamoxifen vs nil), versus no adjuvant treatment, provides a unique opportunity to evaluate long-term 20-year benefit of endocrine therapy within prognostic risk classes of the 70-gene prognosis signature that was developed on adjuvantly untreated patients...
November 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28763917/-analysis-of-the-patterns-of-female-breast-cancer-incidence-in-shanghai-2003-2012
#9
C X Wu, Y Zheng, P P Bao, Z Z Huang, M L Zhang, K Gu, Y M Xiang, P Peng, Y M Gong, W J Zhong
Objective: To analyze the patterns of female breast cancer and their incidence in Shanghai during 2003-2012, and to compare them with international data. Methods: The data of female breast cancer cases diagnosed between 2003 and 2012 were collected from the Shanghai Cancer Registry. The record of cancer cases included the patient's name, gender, date of birth, permanent and residential address, diagnosis site or name, histological type, date of first diagnosis, diagnostic basis and diagnostic stage, etc. Data source of cancer incidence of World, Developed Countries, Developing Countries, East Asia and China in 2012 sourced from GLOBOCAN 2012 database of the WHO International Agency for Research on Cancer (IARC); and the data of USA during 2008-2012 was collected from SEER 18 database from Surveillance, Epidemiology, and End Results Program of the National Cancer Institute (NCI)...
August 6, 2017: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/28763916/-the-coping-styles-and-its-relationship-with-quality-of-life-among-1-968-female-breast-cancer-patients-in-shanghai-in-2014
#10
Q L Deng, C C Zhao, R Y Hu, J W Wang, J M Yu
Objective: To study the coping styles and its relationship with quality of life among part of the female breast cancer patients in Shanghai in 2014. Methods: In August of 2014, 1-3 block groups affiliated to Shanghai Cancer Rehabilitation Club were selected from each of the 17 districts of Shanghai by convenient sampling method. Respondents were recruited from these block groups via putting up posters in the community or top three hospitals nearby. The inclusion criteria were as follows: female, aged from 18 to 80 years old; the initial diagnosis or primary tumor was breast cancer, and active treatments including surgery, radiotherapy and chemotherapy were finished; capable of basic reading and comprehension, and there was no communication disorder; daily activities were not limited, and with no mental disorder or dysgnosia...
August 6, 2017: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/28734894/glce-rs3865014-val597ile-polymorphism-is-associated-with-breast-cancer-susceptibility-and-triple-negative-breast-cancer-in-siberian-population
#11
Valentina A Belyavskaya, Tatiana Y Prudnikova, Natalya V Domanitskaya, Nikolay V Litviakov, Vladimir N Maksimov, Nadezhda V Cherdyntseva, Elvira V Grigorieva
d-Glucuronyl C5-epimerase (GLCE) is one of key enzymes in heparan sulfate biosynthesis and possesses tumour-suppressor function in breast carcinogenesis. Here, we investigated a potential involvement of GLCE polymorphism(s) in breast cancer development in Siberian women population. Comprehensive analysis of SNP databases revealed GLCE rs3865014 (Val597Ile) missense polymorphism as the main significantly present in human populations. According the TaqMan-based SNP assay, allele distributions for the rs3865014 (A>G) were similar in healthy Siberian women (n=136) and cancer patients (n=129) (A0,73:G0,27) and intermediate between the European and Asian populations, while genotype distributions were different, with the increase of AG rate in breast cancer patients (OR=1...
September 10, 2017: Gene
https://www.readbyqxmd.com/read/28702894/21-gene-recurrence-score-and-locoregional-recurrence-in-lymph-node-negative-estrogen-receptor-positive-breast-cancer
#12
Gulisa Turashvili, Joanne F Chou, Edi Brogi, Monica Morrow, Maura Dickler, Larry Norton, Clifford Hudis, Hannah Y Wen
BACKGROUND/PURPOSE: The 21-gene recurrence score (RS) assay evaluates the likelihood of distant recurrence and benefit of chemotherapy in lymph node-negative, estrogen receptor (ER)-positive, HER2-negative breast cancer patients. The RS categories are associated with the risk of locoregional recurrence (LRR) in some, but not all studies. METHODS: We reviewed the institutional database to identify consecutive female patients with node-negative, ER+/HER2- breast carcinoma tested for the 21-gene RS assay and treated at our center from 2008 to 2013...
November 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28605409/hair-product-use-and-breast-cancer-risk-among-african-american-and-white-women
#13
Adana A M Llanos, Anna Rabkin, Elisa V Bandera, Gary Zirpoli, Brian D Gonzalez, Cathleen Y Xing, Bo Qin, Yong Lin, Chi-Chen Hong, Kitaw Demissie, Christine B Ambrosone
Exposures to carcinogens in hair products have been explored as breast cancer risk factors, yielding equivocal findings. We examined hair product use (hair dyes, chemical relaxers and cholesterol or placenta-containing conditioners) among African American (AA) and White women, and explored associations with breast cancer. Multivariable-adjusted models were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) to describe the associations of interest among 2280 cases (1508 AA and 772 White) and 2005 controls (1290 AA and 715 White)...
September 1, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/28592099/-study-of-the-association-between-polymorphism-of-persistent-obesity-human-leptin-gene-leptin-receptor-gene-and-molecular-subtypes-of-breast-cancer
#14
X L Yuan, Z P Xu, C R Liu, L P Yan, P Tao, P Xiong, Q Li, M Zhou, H Li, M Zhao, J Y Li
Objectives: To explore the association between the polymorphism of persistent obesity and genetic variations in the LEP (human leptin gene, LEP) and LEPR (leptin receptor gene, LEPR) genes and different molecular subtypes of breast cancer. Methods: All 703 female patients of breast cancer diagnosed by histopathology in the Sichuan Cancer Hospital or the West China Hospital, excluding patients with metastatic breast cancer or mental disease, were selected as cases from April 2014 to May 2015. At the same time, 805 healthy women received physical examination in medical examination center of Sichuan People Hospital or Shuangliu maternal and child health care hospital, excluding those with therioma, breast disease, and mental disease, were enrolled in control group...
June 6, 2017: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/28550675/-prognostic-value-of-sequencing-of-radiotherapy-and-chemotherapy-following-breast-conserving-surgery-for-patients-with-breast-cancer
#15
Q Z Zhong, Z Wang, Y Tang, Q L Rong, S L Wang, J Jin, W H Wang, Y P Liu, Y W Song, H Fang, B Chen, S N Qi, N Li, Y Tang, J H Zhang, Y X Li
Objective: To evaluate the prognostic value of sequencing of adjuvant radiotherapy and chemotherapy following breast-conserving surgery for patients with breast cancer. Methods: A total of 1 154 patients withT1-2N0-3M0 breast cancer retrospectively reviewed. All patients received sequential radiotherapy and chemotherapy following breast-conserving surgery. Among them, 603 patients received radiotherapy first and 551 patients received chemotherapy first. Log-rank tests were used to determine significance of disease-free survival (DFS) and overall survival (OS) rates in the Kaplan-Meier curve...
April 23, 2017: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/28550667/-clinical-features-and-risk-factors-for-recurrence-in-mucinous-breast-cancer
#16
L Lei, Z Z Chen, Y B Zheng, B Chen, X Wang, X J Wang
Objective: To investigate the clinicopathological characteristic and risk factors for recurrence in different subtypes of mucinous breast cancer(MBC). Methods: Clinical data of 97 MBC patients at Zhejiang Cancer Hospital from August 2005 to November 2012 were retrospectively analyzed. All of patients were divided into 3 subtypes according to the mucinous components in the tumors, named as partial mixed MBC with less than 50% of mucinous components, main mixed MBC where the mucinous component accounted for 50% to 90%, and pure MBC with more than 90% of mucinous components...
April 23, 2017: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/28537988/prevention-of-trastuzumab-and-anthracycline-induced-cardiotoxicity-using-angiotensin-converting-enzyme-inhibitors-or-%C3%AE-blockers-in-older-adults-with-breast-cancer
#17
Saranrat Wittayanukorn, Jingjing Qian, Salisa C Westrick, Nedret Billor, Brandon Johnson, Richard A Hansen
PURPOSE: Although clinical trials have provided some data on the benefit of angiotensin-converting enzyme inhibitors (ACEIs) or β-blockers (BBs) in patients with chemotherapy-induced cardiotoxicity, evidence of ACEIs/BBs on prevention of trastuzumab and/or anthracycline-induced cardiotoxicity outside trials is limited. MATERIALS AND METHODS: A cohort study of 142,990 women (66 y and above) newly diagnosed with breast cancer from 2001 to 2009 was conducted using the Surveillance, Epidemiology, and End Results-Medicare-linked database...
May 23, 2017: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28515068/low-fat-dietary-pattern-and-cardiovascular-disease-results-from-the-women-s-health-initiative-randomized-controlled-trial
#18
RANDOMIZED CONTROLLED TRIAL
Ross L Prentice, Aaron K Aragaki, Linda Van Horn, Cynthia A Thomson, Shirley Aa Beresford, Jennifer Robinson, Linda Snetselaar, Garnet L Anderson, JoAnn E Manson, Matthew A Allison, Jacques E Rossouw, Barbara V Howard
Background: The influence of a low-fat dietary pattern on the cardiovascular health of postmenopausal women continues to be of public health interest.Objective: This report evaluates low-fat dietary pattern influences on cardiovascular disease (CVD) incidence and mortality during the intervention and postintervention phases of the Women's Health Initiative Dietary Modification Trial.Design: Participants comprised 48,835 postmenopausal women aged 50-79 y; 40% were randomly assigned to a low-fat dietary pattern intervention (target of 20% of energy from fat), and 60% were randomly assigned to a usual diet comparison group...
July 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28364196/citizenship-length-of-stay-and-screening-for-breast-cervical-and-colorectal-cancer-in-women-2000-2010
#19
Patricia Y Miranda, Nengliang Yao, S Amy Snipes, Rhonda BeLue, Eugene Lengerich, Marianne M Hillemeier
BACKGROUND: Two factors jointly account for significant gaps in access to health care among immigrants who are present in the U.S.-legal status, and length of residence. The objective of this study is to examine the association between citizenship and length of residence in the U.S. and cancer screening (breast, cervical, and colorectal) among women. METHODS: We analyzed 11 years (2000-2010) of consolidated data from the Medical Expenditure Panel Survey linked with the National Health Interview Survey...
June 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28197686/pre-therapeutic-factors-for-predicting-survival-after-radioembolization-a-single-center-experience-in-389-patients
#20
K J Paprottka, F Schoeppe, M Ingrisch, J Rübenthaler, N N Sommer, E De Toni, H Ilhan, M Zacherl, A Todica, P M Paprottka
PURPOSE: To determine pre-therapeutic predictive factors for overall survival (OS) after yttrium (Y)-90 radioembolization (RE). METHODS: We retrospectively analyzed the pre-therapeutic characteristics (sex, age, tumor entity, hepatic tumor burden, extrahepatic disease [EHD] and liver function [with focus on bilirubin and cholinesterase level]) of 389 consecutive patients with various refractory liver-dominant tumors (hepatocellular carcinoma [HCC], cholangiocarcinoma [CCC], neuroendocrine tumor [NET], colorectal cancer [CRC] and metastatic breast cancer [MBC]), who received Y-90 radioembolization for predicting survival...
July 2017: European Journal of Nuclear Medicine and Molecular Imaging
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