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https://www.readbyqxmd.com/read/28605409/hair-product-use-and-breast-cancer-risk-among-african-american-and-white-women
#1
Adana A M Llanos, Anna Rabkin, Elisa V Bandera, Gary Zirpoli, Brian D Gonzalez, Cathleen Y Xing, Bo Qin, Yong Lin, Chi-Chen Hong, Kitaw Demissie, Christine B Ambrosone
Exposures to carcinogens in hair products have been explored as breast cancer risk factors, yielding equivocal findings. We examined hair product use (hair dyes, chemical relaxers and cholesterol or placenta-containing conditioners) among African American (AA) and White women, and explored associations with breast cancer. Multivariable-adjusted models were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) to describe the associations of interest among 2,280 cases (1,508 AA and 772 White) and 2,005 controls (1,290 AA and 715 White)...
June 9, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/28592099/-study-of-the-association-between-polymorphism-of-persistent-obesity-human-leptin-gene-leptin-receptor-gene-and-molecular-subtypes-of-breast-cancer
#2
X L Yuan, Z P Xu, C R Liu, L P Yan, P Tao, P Xiong, Q Li, M Zhou, H Li, M Zhao, J Y Li
Objectives: To explore the association between the polymorphism of persistent obesity and genetic variations in the LEP (human leptin gene, LEP) and LEPR (leptin receptor gene, LEPR) genes and different molecular subtypes of breast cancer. Methods: All 703 female patients of breast cancer diagnosed by histopathology in the Sichuan Cancer Hospital or the West China Hospital, excluding patients with metastatic breast cancer or mental disease, were selected as cases from April 2014 to May 2015. At the same time, 805 healthy women received physical examination in medical examination center of Sichuan People Hospital or Shuangliu maternal and child health care hospital, excluding those with therioma, breast disease, and mental disease, were enrolled in control group...
June 6, 2017: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/28550675/-prognostic-value-of-sequencing-of-radiotherapy-and-chemotherapy-following-breast-conserving-surgery-for-patients-with-breast-cancer
#3
Q Z Zhong, Z Wang, Y Tang, Q L Rong, S L Wang, J Jin, W H Wang, Y P Liu, Y W Song, H Fang, B Chen, S N Qi, N Li, Y Tang, J H Zhang, Y X Li
Objective: To evaluate the prognostic value of sequencing of adjuvant radiotherapy and chemotherapy following breast-conserving surgery for patients with breast cancer. Methods: A total of 1 154 patients withT1-2N0-3M0 breast cancer retrospectively reviewed. All patients received sequential radiotherapy and chemotherapy following breast-conserving surgery. Among them, 603 patients received radiotherapy first and 551 patients received chemotherapy first. Log-rank tests were used to determine significance of disease-free survival (DFS) and overall survival (OS) rates in the Kaplan-Meier curve...
April 23, 2017: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/28550667/-clinical-features-and-risk-factors-for-recurrence-in-mucinous-breast-cancer
#4
L Lei, Z Z Chen, Y B Zheng, B Chen, X Wang, X J Wang
Objective: To investigate the clinicopathological characteristic and risk factors for recurrence in different subtypes of mucinous breast cancer(MBC). Methods: Clinical data of 97 MBC patients at Zhejiang Cancer Hospital from August 2005 to November 2012 were retrospectively analyzed. All of patients were divided into 3 subtypes according to the mucinous components in the tumors, named as partial mixed MBC with less than 50% of mucinous components, main mixed MBC where the mucinous component accounted for 50% to 90%, and pure MBC with more than 90% of mucinous components...
April 23, 2017: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/28537988/prevention-of-trastuzumab-and-anthracycline-induced-cardiotoxicity-using-angiotensin-converting-enzyme-inhibitors-or-%C3%AE-blockers-in-older-adults-with-breast-cancer
#5
Saranrat Wittayanukorn, Jingjing Qian, Salisa C Westrick, Nedret Billor, Brandon Johnson, Richard A Hansen
PURPOSE: Although clinical trials have provided some data on the benefit of angiotensin-converting enzyme inhibitors (ACEIs) or β-blockers (BBs) in patients with chemotherapy-induced cardiotoxicity, evidence of ACEIs/BBs on prevention of trastuzumab and/or anthracycline-induced cardiotoxicity outside trials is limited. MATERIALS AND METHODS: A cohort study of 142,990 women (66 y and above) newly diagnosed with breast cancer from 2001 to 2009 was conducted using the Surveillance, Epidemiology, and End Results-Medicare-linked database...
May 23, 2017: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28515068/low-fat-dietary-pattern-and-cardiovascular-disease-results-from-the-women-s-health-initiative-randomized-controlled-trial
#6
Ross L Prentice, Aaron K Aragaki, Linda Van Horn, Cynthia A Thomson, Shirley Aa Beresford, Jennifer Robinson, Linda Snetselaar, Garnet L Anderson, JoAnn E Manson, Matthew A Allison, Jacques E Rossouw, Barbara V Howard
Background: The influence of a low-fat dietary pattern on the cardiovascular health of postmenopausal women continues to be of public health interest.Objective: This report evaluates low-fat dietary pattern influences on cardiovascular disease (CVD) incidence and mortality during the intervention and postintervention phases of the Women's Health Initiative Dietary Modification Trial.Design: Participants comprised 48,835 postmenopausal women aged 50-79 y; 40% were randomly assigned to a low-fat dietary pattern intervention (target of 20% of energy from fat), and 60% were randomly assigned to a usual diet comparison group...
May 17, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28364196/citizenship-length-of-stay-and-screening-for-breast-cervical-and-colorectal-cancer-in-women-2000-2010
#7
Patricia Y Miranda, Nengliang Yao, S Amy Snipes, Rhonda BeLue, Eugene Lengerich, Marianne M Hillemeier
BACKGROUND: Two factors jointly account for significant gaps in access to health care among immigrants who are present in the U.S.-legal status, and length of residence. The objective of this study is to examine the association between citizenship and length of residence in the U.S. and cancer screening (breast, cervical, and colorectal) among women. METHODS: We analyzed 11 years (2000-2010) of consolidated data from the Medical Expenditure Panel Survey linked with the National Health Interview Survey...
June 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28197686/pre-therapeutic-factors-for-predicting-survival-after-radioembolization-a-single-center-experience-in-389-patients
#8
K J Paprottka, F Schoeppe, M Ingrisch, J Rübenthaler, N N Sommer, E De Toni, H Ilhan, M Zacherl, A Todica, P M Paprottka
PURPOSE: To determine pre-therapeutic predictive factors for overall survival (OS) after yttrium (Y)-90 radioembolization (RE). METHODS: We retrospectively analyzed the pre-therapeutic characteristics (sex, age, tumor entity, hepatic tumor burden, extrahepatic disease [EHD] and liver function [with focus on bilirubin and cholinesterase level]) of 389 consecutive patients with various refractory liver-dominant tumors (hepatocellular carcinoma [HCC], cholangiocarcinoma [CCC], neuroendocrine tumor [NET], colorectal cancer [CRC] and metastatic breast cancer [MBC]), who received Y-90 radioembolization for predicting survival...
February 14, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28152861/variation-in-use-of-advanced-imaging-at-the-time-of-breast-cancer-diagnosis-in-a-statewide-registry
#9
Thomas Braun, Elizabeth Lusk, Khan Munir, Jennifer J Griggs, David H Gorski, Samuel M Silver, Tara M Breslin, Haythem Y Ali
287 Background: Advanced imaging for diagnosis of metastatic disease at the time of diagnosis of stage 0-II breast cancer is not recommended according to national guidelines. The purpose of this study was to examine the variation in ordering of CT chest, abdomen, and pelvis, PET, and bone scans across the state of Michigan, and to investigate clinical and non-clinical factors associated with test ordering. METHODS: We prospectively collected data from all patients diagnosed with stage 0-II breast cancer from 2008-2014 in 25 health systems in the Michigan Breast Oncology Quality Initiative (MiBOQI), a Blue Cross Blue Shield of Michigan/Blue Care Network-sponsored quality initiative...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28143867/pathological-complete-response-to-neoadjuvant-trastuzumab-is-dependent-on-her2-cep17-ratio-in-her2-amplified-early-breast-cancer
#10
Christian F Singer, Yen Y Tan, Florian Fitzal, Guenther G Steger, Daniel Egle, Angelika Reiner, Margaretha Rudas, Farid Moinfar, Christine Gruber, Edgar Petru, Rupert Bartsch, Kristina A Tendl, David Fuchs, Michael Seifert, Ruth Exner, Marija Balic, Zsuzsanna Bago-Horvath, Martin Filipits, Michael Gnant
PURPOSE: To evaluate whether pathological complete response (pCR) to neoadjuvant trastuzumab is dependent on the level of HER2 amplification. PATIENTS AND METHODS: 114 HER2-overexpressing early breast cancer patients who had received neoadjuvant trastuzumab were included in this study. Absolute HER2 and chromosome 17 centromere (CEP17) were measured by ISH analysis, and associations were examined between HER2/CEP17 ratio and tumor pCR status (commonly defined by ypT0 ypN0, ypT0/is ypN0, and ypT0/is)...
January 31, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28133688/hormone-receptor-status-and-survival-of-medullary-breast-cancer-patients-a-turkish-cohort
#11
Asude Aksoy, Hatice Odabas, Serap Kaya, Oktay Bozkurt, Mustafa Degirmenci, Turkan O Topcu, Aydin Aytekin, Erkan Arpaci, Nilufer Avci, Kezban N Pilanci, Havva Y Cinkir, Yakup Bozkaya, Yalcin Cirak, Mahmut Gumus
OBJECTIVES: To analyze the relationship between clinical features, hormonal receptor status, and survival in patients who were diagnosed with medullary breast cancer (MBC). Methods: Demographic characteristics, histopathological features, and survival statuses of 201 patients diagnosed with MBC between 1995 and 2015 were retrospectively recorded. Survival analyses were conducted with uni- and multivariate cox regression analysis. RESULTS: Median follow-up time was 54 (4-272) months...
February 2017: Saudi Medical Journal
https://www.readbyqxmd.com/read/28046435/we-de-207b-06-artifact-reduction-in-digital-breast-tomosynthesis-with-the-denoised-ordered-subset-statistically-penalized-algebraic-reconstruction-technique-dos-spart-algorithm
#12
J Garrett, Y Li, K Li, G Chen
PURPOSE: Digital breast tomosynthesis (DBT) is an emerging breast imaging modality. It uses x-ray absorption projection images acquired over a narrow angular span to provide high spatial resolution pseudo-three dimensional images for breast cancer screening and diagnosis. Unfortunately, the narrow range used to acquire data (typically <30 degrees) results in significant out of plane artifacts for high contrast objects when conventional reconstruction techniques are used. In this work, the denoised ordered-subset statistically penalized algebraic reconstruction technique (DOS-SPART) algorithm was adapted to breast tomosynthesis imaging to reduce out-of-plane blurring artifacts...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28045923/germline-genetic-variants-in-tek-angpt1-angpt2-mmp9-fgf2-and-vegfa-are-associated-with-pathologic-complete-response-to-bevacizumab-in-breast-cancer-patients
#13
Issam Makhoul, Valentina K Todorova, Eric R Siegel, Stephen W Erickson, Ishwori Dhakal, Vinay R Raj, Jeannette Y Lee, Mohammed S Orloff, Robert J Griffin, Ronda S Henry-Tillman, Suzanne Klimberg, Laura F Hutchins, Susan A Kadlubar
BACKGROUND: We previously reported improved pathologic complete response (pCR) in a prospective phase II study using neoadjuvant bevacizumab in combination with chemotherapy compared to chemotherapy alone in breast cancer patients (41% vs. 25%, p = 0.0291). In this study, we queried germline single-nucleotide polymorphisms (SNPs) in angiogenesis-related genes for their impact on pCR and overall survival (OS). METHODS: DNA for genotyping was available from 34 subjects who received bevacizumab in addition to chemotherapy and 29 subjects who did not...
2017: PloS One
https://www.readbyqxmd.com/read/27998471/-economic-burden-of-cancer-in-china-during-1996-2014-a-systematic-review
#14
J F Shi, C L Shi, X P Yue, H Y Huang, L Wang, J Li, P A Lou, A Y Mao, M Dai
Objective: To explore the current status of research on economic burden of cancer in China from 1996 to 2014. Methods: The key words including cancer, economic burden, expenditure, cost were used to retrieve the literatures published in CNKI and Wanfang (the two most commonly used databases for literature in Chinese) and PubMed during 1996-2014. A total of 91 studies were included after several exclusionary procedures. Information on subjects and data source, methodology, main results were structurally abstracted...
December 23, 2016: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/27833082/discovery-and-replication-of-micrornas-for-breast-cancer-risk-using-genome-wide-profiling
#15
Cenny Taslim, Daniel Y Weng, Theodore M Brasky, Ramona G Dumitrescu, Kun Huang, Bhaskar V S Kallakury, Shiva Krishnan, Adana A Llanos, Catalin Marian, Joseph McElroy, Sallie S Schneider, Scott L Spear, Melissa A Troester, Jo L Freudenheim, Susan Geyer, Peter G Shields
BACKGROUND: Genome-wide miRNA expression may be useful for predicting breast cancer risk and/or for the early detection of breast cancer. RESULTS: A 41-miRNA model distinguished breast cancer risk in the discovery study (accuracy of 83.3%), which was replicated in the independent study (accuracy = 63.4%, P=0.09). Among the 41 miRNA, 20 miRNAs were detectable in serum, and predicted breast cancer occurrence within 18 months of blood draw (accuracy 53%, P=0.06). These risk-related miRNAs were enriched for HER-2 and estrogen-dependent breast cancer signaling...
December 27, 2016: Oncotarget
https://www.readbyqxmd.com/read/27742668/effects-of-exercise-on-insulin-igf-axis-adipocytokines-and-inflammatory-markers-in-breast-cancer-survivors-a-systematic-review-and-meta-analysis
#16
Dong-Woo Kang, Junga Lee, Sang-Hoon Suh, Jennifer Ligibel, Kerry S Courneya, Justin Y Jeon
Background: Insulin, IGF axis, adiponectin, and inflammatory markers are associated with breast cancer. Given that physical activity improves prognosis of breast cancer survivors, we investigated the effects of exercise on these markers as potential mediators between physical activity and breast cancer.Methods: PubMed, EMBASE, CENTRAL, CINAHL, and SportDiscus were searched up to December 3, 2015, to identify randomized controlled trials (RCT) that investigated the effect of exercise on insulin, IGF axis, and cytokines in breast cancer survivors...
October 14, 2016: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/27741204/laparoscopically-confirmed-endometriosis-and-breast-cancer-in-the-nurses-health-study-ii
#17
Leslie V Farland, Rulla M Tamimi, A Heather Eliassen, Donna Spiegelman, Susan E Hankinson, Wendy Y Chen, Stacey A Missmer
OBJECTIVE: To investigate the association between laparoscopically confirmed endometriosis and the risk of breast cancer. Previous research on endometriosis and breast cancer has reported mixed results. METHODS: Our prospective cohort study included 116,430 women from the Nurses' Health Study II cohort followed from 1989 until 2013. Our primary analysis investigated the association between self-reported laparoscopically confirmed endometriosis and the risk of breast cancer...
November 2016: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27672743/outcomes-of-node-positive-breast-cancer-patients-treated-with-accelerated-partial-breast-irradiation-via-multicatheter-interstitial-brachytherapy-the-pooled-registry-of-multicatheter-interstitial-sites-promis-experience
#18
Mitchell Kamrava, Robert R Kuske, Bethany Anderson, Peter Chen, John Hayes, Coral Quiet, Pin-Chieh Wang, Darlene Veruttipong, Margaret Snyder, David J Demanes
OBJECTIVES: To report outcomes for breast-conserving therapy using adjuvant accelerated partial breast irradiation (APBI) with interstitial multicatheter brachytherapy in node-positive compared with node-negative patients. MATERIALS AND METHODS: From 1992 to 2013, 1351 patients (1369 breast cancers) were treated with breast-conserving surgery and adjuvant APBI using interstitial multicatheter brachytherapy. A total of 907 patients (835 node negative, 59 N1a, and 13 N1mic) had >1 year of data available and nodal status information and are the subject of this analysis...
September 26, 2016: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27590617/patient-characteristics-associated-with-undergoing-cancer-operations-at-low-volume-hospitals
#19
Jason B Liu, Karl Y Bilimoria, Katherine Mallin, David P Winchester
BACKGROUND: Although strong volume-outcome relationships exist for many cancer operations, patients continue to undergo these operations at low-volume hospitals. METHODS: Patients were identified from the National Cancer Data Base from 2010-2013 who underwent resection for bladder, breast, esophagus, lung, pancreas, rectum, and stomach cancers. Low-volume hospitals were defined as those in the bottom quartile by surgical volume for each cancer type separately. Logistic regression models were constructed to assess patient-level factors associated with undergoing cancer surgery at low-volume hospitals across cancer types while controlling for tumor characteristics...
February 2017: Surgery
https://www.readbyqxmd.com/read/27565077/operation-with-less-adjuvant-therapy-for-elderly-breast-cancer
#20
Akimitsu Yamada, Kazutaka Narui, Sadatoshi Sugae, Daisuke Shimizu, Kazuaki Takabe, Yasushi Ichikawa, Takashi Ishikawa, Itaru Endo
BACKGROUND: The standard of care for elderly women with breast cancer remains controversial. The aim of this study was to clarify the management of elderly breast cancer patients who undergo surgery. MATERIALS AND METHODS: This retrospective single-center cohort study included 2276 breast cancer patients who underwent surgery between 1993 and 2014. The patients were divided into three groups according to age: ≤64 y (young), 65-74 y (older), and ≥75 y (elderly)...
August 2016: Journal of Surgical Research
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