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https://www.readbyqxmd.com/read/27833082/discovery-and-replication-of-micrornas-for-breast-cancer-risk-using-genome-wide-profiling
#1
Cenny Taslim, Daniel Y Weng, Theodore M Brasky, Ramona G Dumitrescu, Kun Huang, Bhaskar V S Kallakury, Shiva Krishnan, Adana A Llanos, Catalin Marian, Joseph McElroy, Sallie S Schneider, Scott L Spear, Melissa A Troester, Jo L Freudenheim, Susan Geyer, Peter G Shields
BACKGROUND: Genome-wide miRNA expression may be useful for predicting breast cancer risk and/or for the early detection of breast cancer. RESULTS: A 41-miRNA model distinguished breast cancer risk in the discovery study (accuracy of 83.3%), which was replicated in the independent study (accuracy = 63.4%, P=0.09). Among the 41 miRNA, 20 miRNAs were detectable in serum, and predicted breast cancer occurrence within 18 months of blood draw (accuracy 53%, P=0.06). These risk-related miRNAs were enriched for HER-2 and estrogen-dependent breast cancer signaling...
November 9, 2016: Oncotarget
https://www.readbyqxmd.com/read/27742668/effects-of-exercise-on-insulin-igf-axis-adipocytokines-and-inflammatory-markers-in-breast-cancer-survivors-a-systematic-review-and-meta-analysis
#2
Dong-Woo Kang, Junga Lee, Sang-Hoon Suh, Jennifer A Ligibel, Kerry S Courneya, Justin Y Jeon
BACKGROUND: Insulin, insulin-like growth factor-axis, adiponectin, and inflammatory markers are associated with breast cancer. Given that physical activity improve prognosis of breast cancer survivors, we investigated the effects of exercise on these markers as potential mediators between physical activity and breast cancer. METHODS: PubMed, EMBASE, CENTRAL, CINAHL, and SportDiscus were searched up to December 3, 2015 to identify RCTs that investigated the effect of exercise on insulin, insulin-like growth factor axis, and cytokines in breast cancer survivors...
October 14, 2016: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/27741204/laparoscopically-confirmed-endometriosis-and-breast-cancer-in-the-nurses-health-study-ii
#3
Leslie V Farland, Rulla M Tamimi, A Heather Eliassen, Donna Spiegelman, Susan E Hankinson, Wendy Y Chen, Stacey A Missmer
OBJECTIVE: To investigate the association between laparoscopically confirmed endometriosis and the risk of breast cancer. Previous research on endometriosis and breast cancer has reported mixed results. METHODS: Our prospective cohort study included 116,430 women from the Nurses' Health Study II cohort followed from 1989 until 2013. Our primary analysis investigated the association between self-reported laparoscopically confirmed endometriosis and the risk of breast cancer...
November 2016: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27672743/outcomes-of-node-positive-breast-cancer-patients-treated-with-accelerated-partial-breast-irradiation-via-multicatheter-interstitial-brachytherapy-the-pooled-registry-of-multicatheter-interstitial-sites-promis-experience
#4
Mitchell Kamrava, Robert R Kuske, Bethany Anderson, Peter Chen, John Hayes, Coral Quiet, Pin-Chieh Wang, Darlene Veruttipong, Margaret Snyder, David J Demanes
OBJECTIVES: To report outcomes for breast-conserving therapy using adjuvant accelerated partial breast irradiation (APBI) with interstitial multicatheter brachytherapy in node-positive compared with node-negative patients. MATERIALS AND METHODS: From 1992 to 2013, 1351 patients (1369 breast cancers) were treated with breast-conserving surgery and adjuvant APBI using interstitial multicatheter brachytherapy. A total of 907 patients (835 node negative, 59 N1a, and 13 N1mic) had >1 year of data available and nodal status information and are the subject of this analysis...
September 26, 2016: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27590617/patient-characteristics-associated-with-undergoing-cancer-operations-at-low-volume-hospitals
#5
Jason B Liu, Karl Y Bilimoria, Katherine Mallin, David P Winchester
BACKGROUND: Although strong volume-outcome relationships exist for many cancer operations, patients continue to undergo these operations at low-volume hospitals. METHODS: Patients were identified from the National Cancer Data Base from 2010-2013 who underwent resection for bladder, breast, esophagus, lung, pancreas, rectum, and stomach cancers. Low-volume hospitals were defined as those in the bottom quartile by surgical volume for each cancer type separately. Logistic regression models were constructed to assess patient-level factors associated with undergoing cancer surgery at low-volume hospitals across cancer types while controlling for tumor characteristics...
August 30, 2016: Surgery
https://www.readbyqxmd.com/read/27565077/operation-with-less-adjuvant-therapy-for-elderly-breast-cancer
#6
Akimitsu Yamada, Kazutaka Narui, Sadatoshi Sugae, Daisuke Shimizu, Kazuaki Takabe, Yasushi Ichikawa, Takashi Ishikawa, Itaru Endo
BACKGROUND: The standard of care for elderly women with breast cancer remains controversial. The aim of this study was to clarify the management of elderly breast cancer patients who undergo surgery. MATERIALS AND METHODS: This retrospective single-center cohort study included 2276 breast cancer patients who underwent surgery between 1993 and 2014. The patients were divided into three groups according to age: ≤64 y (young), 65-74 y (older), and ≥75 y (elderly)...
August 2016: Journal of Surgical Research
https://www.readbyqxmd.com/read/27510186/lifetime-grain-consumption-and-breast-cancer-risk
#7
Maryam S Farvid, Eunyoung Cho, A Heather Eliassen, Wendy Y Chen, Walter C Willett
We evaluated individual grain-containing foods and whole and refined grain intake during adolescence, early adulthood, and premenopausal years in relation to breast cancer risk in the Nurses' Health Study II. Grain-containing food intakes were reported on a baseline dietary questionnaire (1991) and every 4 years thereafter. Among 90,516 premenopausal women aged 27-44 years, we prospectively identified 3235 invasive breast cancer cases during follow-up to 2013. 44,263 women reported their diet during high school, and from 1998 to 2013, 1347 breast cancer cases were identified among these women...
September 2016: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/27504960/adjuvant-trastuzumab-in-her2-positive-early-breast-cancer-by-age-and-hormone-receptor-status-a-cost-utility-analysis
#8
William Leung, Giorgi Kvizhinadze, Nisha Nair, Tony Blakely
BACKGROUND: The anti-human epidermal growth factor receptor 2 (HER2) monoclonal antibody trastuzumab improves outcomes in patients with node-positive HER2+ early breast cancer. Given trastuzumab's high cost, we aimed to estimate its cost-effectiveness by heterogeneity in age and estrogen receptor (ER) and progesterone receptor (PR) status, which has previously been unexplored, to assist prioritisation. METHODS AND FINDINGS: A cost-utility analysis was performed using a Markov macro-simulation model, with a lifetime horizon, comparing a 12-mo regimen of trastuzumab with chemotherapy alone using the latest (2014) effectiveness measures from landmark randomised trials...
August 2016: PLoS Medicine
https://www.readbyqxmd.com/read/27488234/higher-concentrations-of-serum-iron-and-transferrin-saturation-but-not-serum-ferritin-are-associated-with-cancer-outcomes
#9
Anita Cg Chua, Matthew W Knuiman, Debbie Trinder, Mark L Divitini, John K Olynyk
BACKGROUND: Although the carcinogenic potential of iron has been shown, evidence from observational studies that have linked serum iron variables and cancer outcomes has been inconsistent. OBJECTIVE: We investigated whether higher iron concentrations increased risk of cancer outcomes. DESIGN: A prospective examination of iron biomarkers as independent risk factors for cancer was assessed in 1597 men and 1795 women aged 25-79 y who participated in the 1994/1995 Busselton Health Survey and had relevant data, no history of cancer before the survey, and serum ferritin concentrations ≥20 μg/L...
September 2016: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/27461588/yttrium-90-radioembolization-of-advanced-unresectable-breast-cancer-liver-metastases-a-single-center-experience
#10
Claus Christian Pieper, Carsten Meyer, Kai E Wilhelm, Wolfgang Block, Jennifer Nadal, Hojjat Ahmadzadehfar, Winfried Albert Willinek, Hans Heinz Schild
PURPOSE: To determine value of transarterial radioembolization (TARE) for palliative treatment of unresectable liver-dominant breast metastases (LdBM) and to determine prognostic parameters. MATERIALS AND METHODS: Records of patients undergoing TARE for progressing LdBM between June 2006 and March 2015 were retrospectively reviewed; 44 female patients (mean age 56.1 y; range, 34.9-85.3 y) underwent 69 TAREs (56 resin-based, 13 glass-based). Of 44 patients, 42 had bilobar disease...
September 2016: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/27439856/using-semi-markov-processes-to-study-timeliness-and-tests-used-in-the-diagnostic-evaluation-of-suspected-breast-cancer
#11
R A Hubbard, J Lange, Y Zhang, B A Salim, J R Stroud, L Y T Inoue
Diagnostic evaluation of suspected breast cancer due to abnormal screening mammography results is common, creates anxiety for women and is costly for the healthcare system. Timely evaluation with minimal use of additional diagnostic testing is key to minimizing anxiety and cost. In this paper, we propose a Bayesian semi-Markov model that allows for flexible, semi-parametric specification of the sojourn time distributions and apply our model to an investigation of the process of diagnostic evaluation with mammography, ultrasound and biopsy following an abnormal screening mammogram...
November 30, 2016: Statistics in Medicine
https://www.readbyqxmd.com/read/27320187/-evaluation-of-green-indocyanine-interest-compared-to-technetium-in-sentinel-lymph-node-detection-in-breast-cancer
#12
Y Guenane, M Gorj, V Nguyen, M Revol, S Mazouz-Dorval
INTRODUCTION: Axillary sentinel lymph node (SN) biopsy by using indocyanine green (ICG) fluorescence for breast cancer is a recent technique. However, compared to Technetium-99m (Tc), which is the reference technique, its efficiency has received little testing. MATERIALS AND METHODS: Between December 2013 and January 2014, 40 patients with node-negative breast cancer underwent SN biopsy by injecting sub areolar Tc in preoperative stage and injecting sub areolar ICG in intraoperative stage...
December 2016: Annales de Chirurgie Plastique et Esthétique
https://www.readbyqxmd.com/read/27271767/long-term-cardiovascular-outcomes-and-overall-survival-of-early-stage-breast-cancer-patients-with-early-discontinuation-of-trastuzumab-a-population-based-study
#13
Inna Y Gong, Sunil Verma, Andrew T Yan, Dennis T Ko, Craig C Earle, George A Tomlinson, Maureen E Trudeau, Murray D Krahn, Monika K Krzyzanowska, Christine B Brezden-Masley, Scott Gavura, Stuart Peacock, Kelvin K W Chan
We critically examined long-term cardiovascular (CV) outcomes and overall survival (OS) of breast cancer (BC) patients who had cardiotoxicity during adjuvant trastuzumab treatment requiring discontinuation in a population-based sample. This was a retrospective cohort of early-stage BC patients diagnosed before 2010 and treated with trastuzumab in Ontario. Patients were stratified based on trastuzumab doses received: 1-8, 9-15, ≥16 (therapy completion). Time-dependent multivariable Cox models were used to analyze primary endpoint OS, and the following composite endpoints: hospitalization/emergency room visit for heart failure (HF) or death; non-HF CV (myocardial infarction, stroke) or death; and clinically significant relapse (palliative systemic therapy initiation >90 days after last trastuzumab dose) or death...
June 2016: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/27237442/intra-arterial-radionuclide-therapies-for-liver-tumors
#14
REVIEW
Murat Fani Bozkurt, Bilge Volkan Salanci, Ömer Uğur
Intra-arterial radionuclide therapies serve essentially as internal radiation treatment options for both primary and metastatic liver tumors, which imply delivering implantable radioactive microspheres into branches of hepatic arteries that feed liver tumors to provide a high dose of targeted radiation to tumor tissue, while sparing the healthy liver tissue from hazardous effects of radiation. The principle of this therapeutic option depends on the unique preferential arterial supply of malignant liver tumors in contrast with mostly portal venous supply of normal hepatocytes as well as excess amount of arterial neovascularization in the tumor bed...
July 2016: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/27170029/fruit-and-vegetable-consumption-in-adolescence-and-early-adulthood-and-risk-of-breast-cancer-population-based-cohort-study
#15
Maryam S Farvid, Wendy Y Chen, Karin B Michels, Eunyoung Cho, Walter C Willett, A Heather Eliassen
OBJECTIVE:  To evaluate the association between fruit and vegetable intake during adolescence and early adulthood and risk of breast cancer. DESIGN:  Prospective cohort study. SETTING:  Health professionals in the United States. PARTICIPANTS:  90 476 premenopausal women aged 27-44 from the Nurses' Health Study II who completed a questionnaire on diet in 1991 as well as 44 223 of those women who completed a questionnaire about their diet during adolescence in 1998...
May 11, 2016: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/27065869/inhibition-of-hdac3-and-hdac6-promoted-survivin-expression-plays-an-important-role-in-saha-induced-autophagy-and-viability-reduction-in-breast-cancer-cells
#16
Jane Ying-Chieh Lee, Ching-Wen Kuo, Shing-Ling Tsai, Siao Muk Cheng, Shang-Hung Chen, Hsiu-Han Chan, Chun-Hui Lin, Kun-Yuan Lin, Chien-Feng Li, Jagat R Kanwar, Euphemia Y Leung, Carlos Chun Ho Cheung, Wei-Jan Huang, Yi-Ching Wang, Chun Hei Antonio Cheung
SAHA is a class I HDAC/HDAC6 co-inhibitor and an autophagy inducer currently undergoing clinical investigations in breast cancer patients. However, the molecular mechanism of action of SAHA in breast cancer cells remains unclear. In this study, we found that SAHA is equally effective in targeting cells of different breast cancer subtypes and tamoxifen sensitivity. Importantly, we found that down-regulation of survivin plays an important role in SAHA-induced autophagy and cell viability reduction in human breast cancer cells...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27029367/-analysis-of-the-reported-data-of-national-rural-cervical-cancer-screening-project-from-2012-to-2013-china
#17
X M Luo, L Song, J L Wu, Y Liu, J L Di, B Song, R M Zheng, L Ma
OBJECTIVE: To analyze the reported data of national rural cervical cancer screening project from 2012 to 2013 and to evaluate the project implementation condition. METHODS: Data of the national breast carcinoma and cervical cancer (two-cancer) screening project for rural women were collected from the online report system of key women and children's public health service programs.The screening items included: preliminary screening of cervical lesions (cervical cytology, using Traian Bethesda System(TBS) or Pap grading for classification and reporting), acetate/iodide staining (VIA/VILI), colposcopy, histopathological examination, and pathological diagnosis...
April 2016: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/27005806/feasibility-study-of-axillary-reverse-mapping-for-patients-with-clinically-node-negative-breast-cancer
#18
M Noguchi, M Noguchi, Y Ohno, E Morioka, Y Nakano, T Kosaka, N Kurose, H Minato
BACKGROUND: The axillary reverse mapping (ARM) procedure was developed to identify and preserve arm lymphatic drainage during axillary lymph node dissection (ALND), thereby theoretically reducing the incidence of arm lymphedema. However, the oncological safety of this procedure has not yet been determined. METHODS: Two hundred ninety-two patients with clinically negative nodes (cN0) underwent both sentinel lymph node (SLN) biopsy and ARM. SLN was identified by dye and gamma probe methods, and ARM nodes were identified using a fluorescence imaging system...
May 2016: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27005525/-cancer-burden-in-the-jinchang-cohort
#19
Yana Bai, Hongmei Qu, Hongquan Pu, Min Dai, Ning Cheng, Haiyan Li, Sheng Chang, Juansheng Li, Feng Kang, Xiaobin Hu, Xiaowei Ren, Jie He
OBJECTIVE: To understand the disease burden caused by cancers in Jinchang cohort, and develop effective strategies for cancer prevention and control in this population. METHODS: The cancer mortality data from 2001 to 2013 and the medical records for cancer patients from 2001 to 2010 in Jinchang cohort were collected. The disease burden caused by cancer was analyzed by using mortality rate, potential years of life lost (PYLL), working PYLL (WPYLL), and direct economic burden...
March 2016: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/26966408/genetic-polymorphisms-of-insulin-like-growth-factor-1-and-insulin-like-growth-factor-binding-protein-3-xenoestrogen-phytoestrogen-and-premenopausal-breast-cancer
#20
H Li, M Zhao, Q Wang, L Liu, Y N Qi, J Y Li
BACKGROUND: Previous studies suggest a combined effect of insulin-like growth factor 1 (igf-1) and igf binding protein 3 (igfbp-3) gene polymorphisms, xenoestrogen, and phytoestrogen on the igf-1 signalling pathway and serum concentrations in the igf system, which are associated with premenopausal breast cancer (bca) risk. METHODS: Between 2010 and 2012, our study recruited 140 premenopausal bca patients and 160 community-based premenopausal control subjects. Participants were surveyed about oral contraceptive (oc) use, dietary habits, and other bca risk factors...
February 2016: Current Oncology
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