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https://www.readbyqxmd.com/read/29744298/the-involvement-of-4-1bb-4-1bbl-signaling-in-glial-cell-mediated-hypothalamic-inflammation-in-obesity
#1
Jiye Kim, Yoon-Hee Kwon, Chu-Sook Kim, Thai H Tu, Byung-Sam Kim, Yeonsoo Joe, Hun T Chung, Tsuyoshi Goto, Teruo Kawada, Taesun Park, Myung-Sook Choi, Min-Seon Kim, Rina Yu
Obesity-induced inflammation occurs not only in peripheral tissues but also in areas of the central nervous system. Glial cells such as astrocytes and microglia play crucial roles in obesity-related hypothalamic inflammation, leading to the derangement of energy metabolism and neurodegenerative pathologies. Here, we show that the interaction of 4-1BB/4-1BBL between lipid-laden astrocytes/microglia promotes hypothalamic inflammation in obesity. Stimulation of 4-1BB, a member of the TNF receptor superfamily, and/or its ligand 4-1BBL on astrocytes and/or microglia with a specific agonist resulted in activation of the inflammatory signaling pathway and enhanced production of inflammatory mediators...
May 2018: FEBS Open Bio
https://www.readbyqxmd.com/read/29722432/transcriptome-analysis-of-different-sizes-of-3-mercaptopropionic-acid-modified-cadmium-telluride-quantum-dot-induced-toxic-effects-reveals-immune-response-in-rat-hippocampus
#2
Tianshu Wu, Xue Liang, Keyu He, Tingting Wei, Yan Wang, Lingyue Zou, Jie Lu, Ying Yao, Na Liu, Ting Zhang, Yuying Xue, Meng Tang
Recently, the increasing number of bio-safety assessments on cadmium-containing quantum dots (QDs) suggested that they could lead to detrimental effects on the central nervous system (CNS) of living organisms, but the underlying action mechanisms are still rarely reported. In this study, whole-transcriptome sequencing was performed to analyze the changes in genome-wide gene expression pattern of rat hippocampus after treatments of cadmium telluride (CdTe) QDs with two sizes to understand better the mechanisms of CdTe QDs causing toxic effects in the CNS...
May 3, 2018: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/29698747/neuroprotective-effects-of-metformin-on-traumatic-brain-injury-in-rats-associated-with-nf-%C3%AE%C2%BAb-and-mapk-signaling-pathway
#3
Li Tao, Di Li, Huixiang Liu, Feng Jiang, Yitian Xu, Gang Chen, Ying Cao, Rong Gao
Traumatic brain injury (TBI) triggers a complex sequence of inflammatory responses that contribute to secondary injury. Metformin, a first-line drug used to treat type 2 diabetes, is reported to exhibit potent anti-inflammatory activity on diseases associated with the central nervous system (CNS). The aim of this study is to investigate the potential neuroprotective effects of metformin on acute brain injury after TBI and explore the underlying mechanisms. Male Sprague-Dawley (SD) rats were divided into four groups: sham group, TBI group, TBI + saline (NS) group and TBI + metformin group...
April 23, 2018: Brain Research Bulletin
https://www.readbyqxmd.com/read/29680917/scutellarin-suppresses-neuroinflammation-via-the-inhibition-of-the-akt-nf-%C3%AE%C2%BAb-and-p38-jnk-pathway-in-lps-induced-bv-2-microglial-cells
#4
Pengtao You, San Fu, Kun Yu, Yu Xia, Hezhen Wu, Yanfang Yang, Chaozhi Ma, Dan Liu, Xin Chen, Jun Wang, Xiaochuan Ye, Yanwen Liu
In vitro and in vivo studies indicate that scutellarin (SCU) exerts anti-inflammatory effects in the central nervous system (CNS) and inhibits microglia activation. This study investigated the anti-neuroinflammation molecular mechanisms exerted by scutellarin in LPS-induced BV-2 cells. The results showed that production of TNF-α, IL-1β, IL-6, and NO and TNF-α, IL-1β, IL-6, and iNOS mRNA were inhibited by scutellarin, which was independent of cytotoxicity as assessed by a CCK8 assay. Western blot analysis indicated that NF-κB-p65 phosphorylation was suppressed by scutellarin via inhibition of IκB degradation and IKKβ activation, which coincided with blockage of nuclear translocation of NF-κB as shown by immunofluorescent staining...
April 21, 2018: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/29675728/histone-deacetylase-2-inhibitor-cay10683-alleviates-lipopolysaccharide-induced-neuroinflammation-through-attenuating-tlr4-nf-%C3%AE%C2%BAb-signaling-pathway
#5
Fang-Zhou Jiao, Yao Wang, Hai-Yue Zhang, Wen-Bin Zhang, Lu-Wen Wang, Zuo-Jiong Gong
Neuroinflammation involves in the progression of many central nervous system diseases. Several studies have shown that histone deacetylase (HDAC) inhibitors modulated inflammatory responses in lipopolysaccharide (LPS) stimulated microglia. While, the mechanism is still unclear. The aim of present study was to investigate the effect of HDAC2 inhibitor CAY10683 on inflammatory responses and TLR4/NF-κB signaling pathways in LPS activated BV2 microglial cells and LPS induced mice neuroinflammation. The effect of CAY10683 on cell viability of BV2 microglial cells was detected by CCK-8 assay...
April 19, 2018: Neurochemical Research
https://www.readbyqxmd.com/read/29651950/roles-of-traf6-in-central-nervous-system
#6
Yang Dou, Xiaodi Tian, Jian Zhang, Zhong Wang, Gang Chen
Tumor necrosis factor receptor-associated factor (TRAF) is an important binding protein of tumor necrosis factor (TNF) superfamily and the toll/IL-1 receptor (TIR) superfamily, which play an important role in innate immunity and acquired immunity. TRAFs family has 7 members (TRAF1-7), and TRAF6 has its special facture and biological function. TRAF6 has two special domains: C-terminal domain and N-terminal domain, which could integrate with multiple kinases and regulate signaling pathway function as E3 ubiquitin ligase...
April 11, 2018: Current Neuropharmacology
https://www.readbyqxmd.com/read/29619614/tnf%C3%AE-and-il-1%C3%AE-but-not-il-18-suppresses-hippocampal-long-term-potentiation-directly-at-the-synapse
#7
G Aleph Prieto, Liqi Tong, Erica D Smith, Carl W Cotman
CNS inflammatory responses are linked to cognitive impairment in humans. Research in animal models supports this connection by showing that inflammatory cytokines suppress long-term potentiation (LTP), the best-known cellular correlate of memory. Cytokine-induced modulation of LTP has been previously studied in vivo or in brain slices, two experimental approaches containing multiple cell populations responsive to cytokines. In their target cells, cytokines commonly increase the expression of multiple cytokines, thus increasing the complexity of brain cytokine networks even after single-cytokine challenges...
April 4, 2018: Neurochemical Research
https://www.readbyqxmd.com/read/29603201/pr-957-mediates-neuroprotection-by-inhibiting-th17-differentiation-and-modulating-cytokine-production-in-a-mouse-model-of-ischemic-stroke
#8
Ying Guo, Xiuju Chen, Daojing Li, Haijie Liu, Yanan Ding, Ranran Han, Yanchao Shi, Xiaofeng Ma
Acute ischemic stroke can induce secondary brain injury by activating an inflammatory response that contributes to clinical impairment. As a specific inhibitor of the immunoproteasome subunit low molecular weight polypeptide 7 (LMP7), PR-957 may participate in regulating pathophysiologic and inflammatory responses in multiple diseases of the CNS. We investigated the neuroprotective properties of PR-957 in a mouse model of stroke, induced by middle cerebral artery occlusion (MCAO). After MCAO and injections of PR-957 or vehicle, we evaluated mice behaviorally using modified Neurological Severity Scores (mNSS) and sensorimotor tests, including the adhesive-removal test, a foot-fault test, and an inclined plane test...
March 30, 2018: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/29580899/investigation-of-candidate-long-noncoding-rnas-and-messenger-rnas-in-the-immediate-phase-of-spinal-cord-injury-based-on-gene-expression-profiles
#9
Hengxing Zhou, Zhongju Shi, Yi Kang, Yao Wang, Lu Lu, Bin Pan, Jun Liu, Xueying Li, Lu Liu, Zhijian Wei, Xiaohong Kong, Shiqing Feng
Spinal cord injury (SCI) is a serious devastating condition and it has a high mortality rate and morbidity rate. The early pathological changes in the immediate phase of SCI may play a major part in the development of secondary injury. Alterations in the expression of many long noncoding RNAs (lncRNAs) have been shown to play fundamental roles in the diseases of the central nervous system. However, the roles of lncRNAs and messenger RNAs (mRNAs) in the immediate phase of SCI are not clear. We examined the expression of mRNAs and lncRNAs in a rat model at 2 h after SCI and identified the differentially expressed lncRNAs (DE lncRNAs) and differentially expressed mRNAs (DE mRNAs) using microarray analysis...
March 23, 2018: Gene
https://www.readbyqxmd.com/read/29548997/fty720-attenuates-behavioral-deficits-in-a-murine-model-of-systemic-lupus-erythematosus
#10
Dongyan Shi, Tongguan Tian, Shu Yao, Kelei Cao, Xingxing Zhu, Mingshun Zhang, Shuang Wen, Longjun Li, Meiqing Shi, Hong Zhou
Neuropsychiatric (NP) involvement in systemic lupus erythematosus (SLE) severely impacts patients' quality of life and leads to a poor prognosis. The current therapeutic protocol, corticosteroid administration, can also induce neuropsychiatric disorders. FTY720 is an immunomodulator that selectively confines lymphocytes in lymph nodes and reduces autoreactive T cell recruitment to the central nervous system (CNS). This study aimed to identify a novel therapeutic strategy for NPSLE. B6.MRL-lpr mice were treated with oral administration of FTY720 (2 mg/kg) three times per week for 12 weeks, to evaluate its efficacy in a model of NPSLE...
March 13, 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29544517/lentivirus-mediated-overexpression-of-otulin-ameliorates-microglia-activation-and-neuroinflammation-by-depressing-the-activation-of-the-nf-%C3%AE%C2%BAb-signaling-pathway-in-cerebral-ischemia-reperfusion-rats
#11
Hongbei Xu, Wenyi Qin, Xiao Hu, Song Mu, Jun Zhu, Wenhao Lu, Yong Luo
BACKGROUND: Ischemic stroke-induced neuroinflammation is mainly mediated by microglial cells. The nuclear factor kappa B (NF-κB) pathway is the key transcriptional pathway that initiates inflammatory responses following cerebral ischemia. OTULIN, a critical negative regulator of the NF-κΒ signaling pathway, exerts robust effects on peripheral immune cell-mediated inflammation and is regarded as an essential mediator for repressing inflammation in vivo. The effect of OTULIN on inflammatory responses in the central nervous system (CNS) was previously unstudied...
March 15, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29522792/differences-in-statin-associated-neuroprotection-corresponds-with-either-decreased-production-of-il-1%C3%AE-or-tnf-%C3%AE-in-an-in-vitro-model-of-neuroinflammation-induced-neurodegeneration
#12
A J McFarland, A K Davey, C M McDermott, G D Grant, J Lewohl, S Anoopkumar-Dukie
3-Hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors (statins) have been associated with conflicting effects within the central nervous system (CNS), with underlying mechanisms remaining unclear. Although differences between individual statins' CNS effects have been reported clinically, few studies to date have compared multiple statins' neuroprotective effects. This study aimed to compare six statins (atorvastatin, fluvastatin, pitavastatin, pravastatin, rosuvastatin, simvastatin; 0-100 μM) using an in vitro model of lipopolysaccharide (LPS)-induced neuroinflammation and subsequent neurodegeneration...
April 1, 2018: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29487525/alcohol-mediated-organ-damages-heart-and-brain
#13
REVIEW
Adam Obad, Ahmed Peeran, Janay I Little, Georges E Haddad, Sima T Tarzami
Alcohol is one of the most commonly abused substances in the United States. Chronic consumption of ethanol has been responsible for numerous chronic diseases and conditions globally. The underlying mechanism of liver injury has been studied in depth, however, far fewer studies have examined other organs especially the heart and the central nervous system (CNS). The authors conducted a narrative review on the relationship of alcohol with heart disease and dementia. With that in mind, a complex relationship between inflammation and cardiovascular disease and dementia has been long proposed but inflammatory biomarkers have gained more attention lately...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29477598/rage-and-its-emerging-role-in-the-pathogenesis-of-parkinson-s-disease
#14
Xiuli Jiang, Xiaoli Wang, Miao Tuo, Jiangnan Ma, Anmu Xie
Receptor for advanced glycation end products (RAGE) is a multiligand receptor belonging to the immunoglobulin superfamily and plays crucial roles in the development of many human diseases such as neurodegenerative diseases, diabetes, cardiovascular diseases, osteoarthritis and cancer. RAGE involves in a number of cell processes such as neuroinflammation, apoptosis, proliferation and autophagy. In CNS, RAGE was primarily expressed in neurons, microglia and vascular endothelial cells. Interacting with ligands, RAGE induces a series of signal transduction cascades and leads to the activation of transcription factor NF-κB as well as increased expression of cytokines like TNF-α, IL-1...
April 13, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29462849/synthetic-3-4-dihydroxyflavone-exerts-anti-neuroinflammatory-effects-in-bv2-microglia-and-a-mouse-model
#15
Namkwon Kim, Hyung-Seok Yoo, Yeon-Joo Ju, Myung Sook Oh, Kyung-Tae Lee, Kyung-Soo Inn, Nam-Jung Kim, Jong Kil Lee
Neuroinflammation is an immune response within the central nervous system against various proinflammatory stimuli. Abnormal activation of this response contributes to neurodegenerative diseases such as Parkinson disease, Alzheimer's disease, and Huntington disease. Therefore, pharmacologic modulation of abnormal neuroinflammation is thought to be a promising approach to amelioration of neurodegenerative diseases. In this study, we evaluated the synthetic flavone derivative 3',4'-dihydroxyflavone, investigating its anti-neuroinflammatory activity in BV2 microglial cells and in a mouse model...
March 1, 2018: Biomolecules & Therapeutics
https://www.readbyqxmd.com/read/29412789/long-term-treatment-by-mesenchymal-stem-cells-conditioned-medium-modulates-cellular-molecular-and-behavioral-aspects-of-adjuvant-induced-arthritis
#16
Vida Nazemian, Homa Manaheji, Ali Mohammad Sharifi, Jalal Zaringhalam
Neuroinflammation plays a crucial role in expression of symptoms of numerous autoimmune and neurodegenerative diseases such as pain during rheumatoid arthritis. Overproduction of pro-inflammatory cytokines and activation of intracellular signaling pathways have been strongly implicated in the generation of pathological pain states, particularly at central nervous system sites and induction of spinal neuroinflammatory symptoms. The wide ranges of research to define new therapeutic approaches, including neuroimmune-modulators like stem cells are in progress...
January 31, 2018: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/29393419/hmgb1-mediates-microglia-activation-via-the-tlr4-nf-%C3%AE%C2%BAb-pathway-in-coriaria-lactone-induced-epilepsy
#17
Yunbo Shi, Lingli Zhang, Junfang Teng, Wang Miao
Epilepsy is a chronic and recurrent disease of the central nervous system, with a complex pathology. Recent studies have demonstrated that the activation of glial cells serve an important role in the development of epilepsy. The objective of the present study was to investigate the role of high‑mobility group box‑1 (HMGB1) in mediating the activation of glial cells through the toll‑like receptor 4 (TLR4)/nuclear factor (NF)‑κB signaling pathway in seizure, and the underlying mechanism. The brain tissue of post‑surgery patients with intractable epilepsy after resection and the normal control brain tissue of patients with craniocerebral trauma induced intracranial hypertension were collected...
April 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29345065/fingolimod-targets-cerebral-endothelial-activation-to-block-leukocyte-recruitment-in-the-central-nervous-system
#18
Yawei Zhao, Dongyan Shi, Kelei Cao, Fengjiao Wu, Xingxing Zhu, Shuang Wen, Qiang You, Keqi Zhang, Lixin Liu, Hong Zhou
Fingolimod (FTY720), an immunomodulator, is approved as an oral treatment for patients with relapsing forms of multiple sclerosis. Its effects are largely attributed to its mechanism of selectively retaining lymphocytes in the lymph nodes to reduce autoreactive T-cell recruitment in the CNS. In this study, we investigated the therapeutic effect of FTY720 on an animal model of CNS inflammation induced by intracerebral ventricle LPS injection. We found that FTY720 treatment significantly prevented LPS-induced neutrophil recruitment in the CNS by inhibiting leukocyte recruitment in cerebral microvessels...
January 2018: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/29223154/antiinflammatory-effect-of-rosiglitazone-via-modulation-of-mrna-stability-of-interleukin-10-and-cyclooxygenase-2-in-astrocytes
#19
E V Pankevich, A A Astakhova, D V Chistyakov, M G Sergeeva
Investigation of molecular mechanisms of proinflammatory stimuli signaling in astrocytes is important for understanding their role in pathogenesis of central nervous system diseases as well as in functioning of the innate immunity system in non-immune cells. Here we show that lipopolysaccharide (LPS) stimulation of primary rat astrocytes led to conventional inflammatory response: increase in both proinflammatory (tumor necrosis factor, TNFα; prostaglandin E2 , PGE2 ) and antiinflammatory marker (interleukin 10, IL-10) levels...
November 2017: Biochemistry. Biokhimii︠a︡
https://www.readbyqxmd.com/read/29201025/regulation-of-neuroinflammation-what-role-for-the-tumor-necrosis-factor-like-weak-inducer-of-apoptosis-fn14-pathway
#20
REVIEW
Audrey Boulamery, Sophie Desplat-Jégo
Observed in many central nervous system diseases, neuroinflammation (NI) proceeds from peripheral immune cell infiltration into the parenchyma, from cytokine secretion and from oxidative stress. Astrocytes and microglia also get activated and proliferate. NI manifestations and consequences depend on its context and on the acute or chronic aspect of the disease. The tumor necrosis factor-like weak inducer of apoptosis (TWEAK)/Fn14 pathway has been involved in chronic human inflammatory pathologies such as neurodegenerative, autoimmune, or malignant diseases...
2017: Frontiers in Immunology
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