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Manish Devendra Mair, Sudhir Nair, Santosh Nikam, Deepa Nair, Jai Prakash Agarwal, Pankaj Chaturvedi
OBJECTIVE: Quality of life (QOL) has become an important aspect of today's health care management. This study performed longitudinal assessment of QOL in patients with advanced cancers of the buccal mucosa (T4). We compared the QOL between patients who received adjuvant chemoradiation therapy (CTRT) and that of patients who received radiation therapy alone and assessed whether baseline QOL can predict disease recurrence. STUDY DESIGN: This was a prospective study of 225 patients with T4 buccal mucosal cancer...
December 2017: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Annette J van Nieuwenhuizen, Laurien M Buffart, Cornelia F van Uden-Kraan, Lilly-Ann van der Velden, Martin Lacko, Johannes Brug, C René Leemans, Irma M Verdonck-de Leeuw
PURPOSE: This study aimed to assess patient-reported levels of physical activity (PA) and its associations with health-related quality of life (HRQoL) adjusted for important demographic, lifestyle-related, and clinical factors, among head and neck (HNC) survivors. METHODS: This cross-sectional study included 116 HNC survivors. PA was assessed with the Physical Activity Scale for the Elderly (PASE) and HRQoL with the EORTC-QLQ-C30 and EORTC-HN35. Associations were studied using univariable and multivariable regression analyses...
November 21, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
Giacomo Oteri, Francesco Saverio De Ponte, Michele Runci, Matteo Peditto, Antonia Marcianò, Marco Cicciù
The aim of this study is to analyze the clinical outcome and the change in oral-health-related quality of life (QoL) of osteoporotic patients affected by medication-related osteonecrosis of the jaws (MRONJ). Forty-one patients, consecutively treated for a 10-year period, were retrospectively analyzed. All the patients underwent a marginal osseous resective jaw surgery. A clinical 12 months postoperative evaluation has been performed and the complete mucosal healing, the absence of swelling and suppuration, and no signs of disease recurrence were defined like success parameters...
November 9, 2017: Journal of Craniofacial Surgery
Edvard Abel, Ewa Silander, Jan Nyman, Mogens Bove, Leif Johansson, Thomas Björk-Eriksson, Eva Hammerlid
Objective: The purpose of this study was to prospectively and longitudinally compare the health-related quality of life (HRQOL) outcomes between head and neck (HN) cancer patients treated with parotid-sparing intensity modulated radiation therapy (IMRT) and patients treated with 3-dimensional conventional radiation therapy (3D-CRT). Methods and materials: Before and up to 12 months after treatment, HRQOL was recorded in patients with HN cancer who were referred to the Department of Oncology at Sahlgrenska University Hospital for curative IMRT...
July 2017: Advances in Radiation Oncology
Eva Hammerlid, Ali Adnan, Ewa Silander
BACKGROUND: The purpose of this study was to establish population-based norms for the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Head and Neck 35 (EORTC QLQ-HN35) to be used as references to facilitate the interpretation of results from health-related quality of life (HRQOL) studies of patients with head and neck cancer. METHODS: The European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30 (EORTC QLQ-C30) and QLQ-HN35 were sent to a random sample representing the Swedish general population...
July 14, 2017: Head & Neck
Ioli Ioanna Artopoulou, Evangelos C Karademas, Nikolaos Papadogeorgakis, Ioannis Papathanasiou, Gregory Polyzois
STATEMENT OF PROBLEM: Restoration of maxillary defects resulting from tumor ablative surgery presents a difficult challenge, with both functional and esthetic issues. Whether rehabilitation with an obturator prosthesis could significantly contribute to improved quality of life in patients with maxillary resection has been scarcely studied, with relatively small study samples. PURPOSE: The purpose of this survey study was to assess the overall functioning of the obturator prosthesis and the effect of specific sociodemographic, medical, and treatment variables on obturator functioning and quality of life in patients with maxillectomy...
December 2017: Journal of Prosthetic Dentistry
Ying Nie, Da-Qing Wang, Guang Zhao, Song Yu, Hong-Yan Wang
The development of transgenic soybean has produced numerous economic benefits; however the potential impact of root exudates upon soil ecological systems and rhizospheric soil microbial diversity has also received intensive attention. In the present study, the influence of saline-alkali tolerant transgenic soybean of betaine aldehyde dehydrogenase on bacterial community structure and soil phosphatase during growth stages was investigated. The results showed that, compared with nontransgenic soybean as a control, the rhizospheric soil pH of transgenic soybean significantly decreased at the seedling stage...
2016: BioMed Research International
Sindhu Nagaraja, S Amrut Kadam, Karthikeyan Selvaraj, Iqbal Ahmed, Rajesh Javarappa
CONTEXT: Trismus is one of the common late side effects of radiotherapy (RT) of head and neck cancers. It occurs in about 30% of patients treated by telecobalt. It, in turn, leads to significant morbidity, including malnutrition, difficulty in speaking, and compromised oral hygiene with severe psychosocial, and economic impacts. AIMS: To determine the prevalence of trismus and its progression in patients who have received radical concurrent chemoradiation for head and neck cancer by telecobalt at our institution...
April 2016: Journal of Cancer Research and Therapeutics
Suelen Patrícia Dos Santos Martins, Cynthia Lemos Ferreira, Auro Del Giglio
Fatigue is a common symptom in patients with head and neck carcinoma who undergo chemoradiotherapy. Guarana (Paullinia cupana) is a plant that grows in the Brazilian Amazon region that was used previously to treat fatigue induced by chemotherapy. METHODS: In this phase II prospective study, we evaluated 60 patients with stage I-IV head and neck squamous cell carcinoma before, during, and after chemoradiotherapy. The patients were randomized into two arms: placebo versus guarana at a dose of 50 mg twice a day during the chemoradiotherapy treatment...
June 20, 2016: Journal of Dietary Supplements
Adorján F Kovács, Ulrich Stefenelli, Gerrit Thorn
BACKGROUND: Quality of life (QoL) studies are well established when accompanying trials in head and neck cancer, but studies on long-term survivors are rare. AIMS: The aim was to evaluate long-term follow-up patients treated with an intensified multi-modality therapy. SETTING AND DESIGN: Cross-sectional study, tertiary care center. PATIENTS AND METHODS: A total of 135 oral/oropharyngeal cancer survivors having been treated with an effective four modality treatment (intra-arterial induction chemotherapy, radical surgery, adjuvant radiation, concurrent systemic chemotherapy) filled European Organisation for Research and Treatment of Cancer (EORTC) QLQ-C30 and HN35 questionnaires...
January 2015: Annals of Maxillofacial Surgery
Shin-Ae Kim, Jong-Lyel Roh, Sang-Ah Lee, Sang-Wook Lee, Sung-Bae Kim, Seung-Ho Choi, Soon Yuhl Nam, Sang Yoon Kim
BACKGROUND: The emotional status of cancer patients is associated with disease course and treatment outcomes. In this study, the authors evaluated associations between the presence of pretreatment depression and pretreatment quality of life (QOL), nutritional status, and survival outcomes in patients with head and neck squamous cell carcinoma (HNSCC). METHODS: For this prospective study, 241 patients with previously untreated HNSCC who underwent curative treatments were enrolled...
January 1, 2016: Cancer
Rudolf Hagen, Matthias Scheich, Norbert Kleinsasser, Marc Burghartz
Xerostomia is a persistent side effect of radiotherapy (RT), which severely reduces the quality of life of the patients affected. Besides drug treatment and new irradiation strategies, surgical procedures aim for tissue protection of the submandibular gland. Using a new surgical approach, the submandibular gland was autotransplanted in 6 patients to the patient's forearm for the period of RT and reimplanted into the floor of the mouth 2-3 months after completion of RT. Saxon's test was performed during different time points to evaluate patient's saliva production...
August 2016: European Archives of Oto-rhino-laryngology
Silke Tribius, Marieclaire Raguse, Christian Voigt, Adrian Münscher, Alexander Gröbe, Cordula Petersen, Andreas Krüll, Corinna Bergelt, Susanne Singer
PURPOSE: Patients with locally advanced head and neck cancer (LAHNC) undergo life-changing treatments that can seriously affect quality of life (QoL). This prospective study examined the key QoL domains during the first year after intensity-modulated radiotherapy (IMRT) and identified predictors of these changes in order to improve patient outcomes. PATIENTS AND METHODS: A consecutive series of patients with LAHNC completed the European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire Core module (QLQ-C30) and the HNC-specific QLQ-HN35 before (t0) and at the end (t1) of definitive or adjuvant IMRT, then at 6-8 weeks (t2), 6 months (t3), and 1 year (t4) after IMRT...
June 2015: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
Li-Yun Lee, Shu-Ching Chen, Wen-Cheng Chen, Bing-Shen Huang, Chien-Yu Lin
OBJECTIVE: The aims of this study were to investigate the following in patients with head and neck cancer (HNC): (1) factors related to trismus that predict the development of trismus, (2) factors affecting quality of life and measurements of these factors, and (3) comparison of these findings in patients with and without trismus to evaluate the effects of trismus on quality of life. METHODS: This cross-sectional study included the questionnaires: the Hospital Anxiety and Depression Scale (HADS) - Depression Subscale, the Chewing Function Questionnaire (CFQ), and the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire - Head and Neck Cancer Module (EORTC QLQ-HN35)...
February 2015: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Punita Lal, Vipul Nautiyal, Tamojit Chaudhuri, Mranalini Verma, Koilpillai Joseph Das, Shaleen Kumar
BACKGROUND: Patients with cancers of the upper aerodigestive tract (head and neck cancer (HNC)) tend to aspirate, either due to disease or treatment. The association of aspiration (documented on video fluorography (VFG)) with quality of life (QOL) and unexpected mortality was studied prospectively in patients treated with simultaneous integrated boost technique of intensity-modulated radiotherapy (SIB-IMRT). MATERIALS AND METHODS: Moderately advanced (stage III/IV) HNC were treated by SIB-IMRT delivering 66 Gy/30 fr, 60 Gy/30 fr, and 54 Gy/30 fr to high, intermediate, and low risk volumes, respectively...
October 2014: South Asian Journal of Cancer
Ajeet Kumar Gandhi, Soumyajit Roy, Alok Thakar, Atul Sharma, Bidhu Kalyan Mohanti
AIM: Head and neck cancers (HNCa) are the most common cancers among males in India and 70-80% present in advanced stage. The study aims to assess symptom burden and quality of life (QOL) in advanced incurable HNCa patients at presentation. MATERIALS AND METHODS: One hundred patients were asked to fill EORTC QLQ-C15-PAL questionnaire, which consisted of Global QOL, physical functioning (PF), emotional functioning (EF), fatigue (FA), nausea-vomiting (NV), pain (PA), dyspnea (DY), sleep (SL), appetite (AP), and constipation (CO)...
September 2014: Indian Journal of Palliative Care
R N P M Rinkel, I M Verdonck-de Leeuw, N van den Brakel, R de Bree, S E J Eerenstein, N Aaronson, C R Leemans
OBJECTIVES: To validate questionnaires on voice, speech, and swallowing among laryngeal cancer patients, to assess the need for and use of rehabilitation services, and to determine the association between voice, speech, and swallowing problems, and quality of life and distress. MATERIALS AND METHODS: Laryngeal cancer patients at least three months post-treatment completed the VHI (voice), SHI (speech), SWAL-QOL (swallowing), EORTC QLQ-C30, QLQ-HN35, HADS, and study-specific questions on rehabilitation...
August 2014: Oral Oncology
Don-Felix Ryzek, Konstantinos Mantsopoulos, Julian Künzel, Philipp Grundtner, Johannes Zenk, Heinrich Iro, Georgios Psychogios
OBJECTIVE: To compare long-term quality of life outcomes after treating early stage oropharyngeal carcinoma either with surgery, surgery combined with radiotherapy, or surgery combined with chemoradiotherapy. METHODS: Questionnaire based method: 111 eligible patients agreed to fill out a quality of life questionnaire. RESULTS: Of the 32 scales contained in the EORTC's combined QLQ-C30 and HN35, 11 scales show significantly better results for the surgery-only treatment group when compared to either surgery combined with radiotherapy or surgery combined with any type of adjuvant therapy...
2014: BioMed Research International
L Pottel, M Lycke, T Boterberg, H Pottel, L Goethals, F Duprez, N Van Den Noortgate, W De Neve, S Rottey, K Geldhof, V Buyse, K Kargar-Samani, V Ghekiere, P R Debruyne
Head and neck (H&N) cancer is mainly a cancer of the elderly; however, the implementation of comprehensive geriatric assessment (CGA) to quantify functional age in these patients has not yet been studied. We evaluated the diagnostic performance of screening tools [Vulnerable Elders Survey-13 (VES-13), G8 and the Combined Screening Tool 'VES-13 + (17-G8)' or CST], the feasibility of serial CGA, and correlations with health-related quality of life evolution [HRQOL; European Organisation for Research and Treatment of Cancer Quality of Life Questionnaires (EORTC QLQ)-C30 and -HN35] during therapy in hundred patients, aged ≥65 years, with primary H&N cancer undergoing curative radio(chemo)therapy...
May 2014: European Journal of Cancer Care
Anthony K Crombie, Camile S Farah, Martin D Batstone
Our aim was to document the health-related quality of life (QoL) of patients with squamous cell carcinoma (SCC) of the oral cavity who were treated with chemoradiotherapy, and to compare it with that of patients treated with conventional surgery with or without adjuvant treatment. All patients who presented with SCC of the oral cavity treated with chemoradiotherapy alone at the Royal Brisbane & Women's Hospital between 2000 and 2011 and who were alive without disease were included. Health-related QoL was assessed by the University of Washington QoL questionnaire version 4, and the European Organisation for the Research and Treatment of Cancer (EORTC) QoL questionnaires C30 and HN35...
February 2014: British Journal of Oral & Maxillofacial Surgery
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