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Alejandro A Gru, Patrick J Voorhess
Anaplastic large-cell lymphoma (ALCL) was first described in 1985 by Stein et al and is a clinically, morphologically, and immunophenotypically heterogeneous neoplasm characterized by ALK expression, rearrangement of the ALK gene, and most characteristically its occurrence in children. Clinically, cutaneous ALK+ ALCL can be divided into primary (cutaneous forms) and the much more common, secondary dissemination by a systemic lymphoma. Systemic ALK+ ALCL represents 10%-15% of childhood non-Hodgkin lymphoma and generally presents with advanced systemic disease...
November 27, 2017: American Journal of Dermatopathology
Manuela Krumbholz, Wilhelm Woessmann, Jakob Zierk, David Seniuk, Paolo Ceppi, Martin Zimmermann, Vijay Kumar Singh, Markus Metzler, Christine Damm-Welk
Nucleophosmin-anaplastic lymphoma kinase ( NPM-ALK) fusion genes resulting from the translocation t(2;5)(p23;q35) are present in almost 90% of childhood ALK-positive anaplastic large-cell lymphomas (ALCL). Detection and quantification of minimal disseminated disease (MDD) by measuring NPM-ALK fusion transcript levels in the blood provide independent prognostic parameters. Characterization of the genomic breakpoints provides insights into the pathogenesis of the translocation and allows for DNA-based minimal disease monitoring...
May 29, 2018: Oncotarget
Cristiane R Ferreira, Shuchun Zhao, Malaya K Sahoo, Benjamin Pinsky, Jenna Weber, Luis A P C Lage, Juliana Pereira, Maria C N Zerbini, Yasodha Natkunam
Forkhead box P3 (FOXP3) is a specific marker for regulatory T-cells (Tregs). We report 6 cases of T-cell lymphomas with Treg phenotype based on diffuse positivity for FOXP3 in tumor cells. The patients showed a median age of 56years with a male predominance. Sites of disease included lymph nodes (4), skin (2), subcutaneous tissue (1) and bone marrow (1). All cases showed monomorphic large cells, some with Hodgkin-like or anaplastic cells. All cases expressed pan T cell markers and lacked cytotoxic markers; one case showed diffuse PD1 staining...
June 10, 2018: Human Pathology
Zhanyu Li, Jian Liu, Bangbang Niu, Jianling Li, Feiyu Kang
Herein, a novel graphite-graphite dual ion battery (GGDIB) based on a AlCl3 /1-ethyl-3-methylimidazole Cl ([EMIm]Cl) room temperature ionic liquid electrolyte, using conductive graphite paper as cathode and anode material is developed. The working principle of the GGDIB is investigated, that is, metallic aluminum is deposited/dissolved on the surface of the anode, and chloroaluminate ions are intercalated/deintercalated in the cathode material. The self-discharge phenomenon and pseudocapacitive behavior of the GGDIB are also analyzed...
June 7, 2018: Small
Linda Ager-Wick Ellingsen, Alex Holland, Jean-Francois Drillet, Willi Peters, Martin Eckert, Carlos Concepcion, Oscar Ruiz, Jean-François Colin, Etienne Knipping, Qiaoyan Pan, Richard G A Wills, Guillaume Majeau-Bettez
Recently, rechargeable aluminum batteries have received much attention due to their low cost, easy operation, and high safety. As the research into rechargeable aluminum batteries with a room-temperature ionic liquid electrolyte is relatively new, research efforts have focused on finding suitable electrode materials. An understanding of the environmental aspects of electrode materials is essential to make informed and conscious decisions in aluminum battery development. The purpose of this study was to evaluate and compare the relative environmental performance of electrode material candidates for rechargeable aluminum batteries with an AlCl₃/EMIMCl (1-ethyl-3-methylimidazolium chloride) room-temperature ionic liquid electrolyte...
June 1, 2018: Materials
Zhi-Kun Wang, Xiao-Jun Shen, Jun-Jie Chen, Ying-Qiu Jiang, Zhi-Yan Hu, Xing Wang, Li Liu
Herein, an efficient DES/MIBK biphasic pretreatment system for preparation of furfural and fermentable glucose from lignocellulose was developed with AlCl3 as catalysis. The low-cost and renewable DES (Choline chloride-Oxalic acid) served not only as a Brønsted acid catalyst, but also as a pretreatment solvent in present work, and MIBK as an extracting reagent which can increase the yield of furfural in DES phase. The effects of this biphasic pretreatment on the furfural yield and saccharification of the lignocellulose before and after pretreatment were explored using HPLC, HAPEC, FT-IR, XRD and SEM...
June 1, 2018: International Journal of Biological Macromolecules
Chumki Banik, Michael Lawrinenko, Santanu Bakshi, David A Laird
The capacity of biochars to adsorb ionic contaminants is strongly influenced by biochar surface chemistry. We studied the effects of biomass feedstock type, pyrolysis temperature, reaction media pH, and AlCl pre-pyrolysis feedstock treatments on biochar anion exchange capacity (AEC), cation exchange capacity (CEC), point of zero net charge (PZNC), and point of zero salt effect (PZSE). We used the relationship between PZNC and PZSE to probe biochar surfaces for the presence of unstable (hydrolyzable) surface charge functional groups...
May 2018: Journal of Environmental Quality
Rajkumar Kore, Steven P Kelley, Pavankumar Aduri, Robin D Rogers
Two solids of differing Lewis acidities, triethylammonium tetrachlorozincate ([HN222]2[ZnCl4]) and AlCl3, have been combined across 0.1 to 0.9 mole fractions (with respect to [HN222]2[ZnCl4]), and homogeneous solid double salts or mixed metal [HN222]2x[(1 - x)AlCl3 + xZnCl4] double salt ionic liquids (DSILs) were obtained at x = 0.33, 0.4, and 0.5 with varying Lewis acidities. The characterization of the prepared DSILs (melting point, color, homogeneity, 1H, 13C, and 27Al nuclear magnetic resonance spectroscopy (NMR), infrared spectroscopy (IR), single crystal X-ray diffraction (SCXRD), and matrix-assisted laser-desorption ionization time-of-flight (MALDI-TOF) mass spectrometry) suggests that [HN222]2[ZnCl4] transfers Cl- from [ZnCl4]2- to the stronger Lewis acid AlCl3, forming intermediate acidic DSILs with [AlCl4]- and [Al2Cl7]- anions and mixed anionic Zn species...
May 31, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
Natalia Buchely, Rami Al-Rohil, Phyu P Aung, George Jour, Carlos Torres-Cabala, Victor G Prieto, Doina Ivan
Mycosis fungoides (MF) is the most common variant of cutaneous T-cell lymphomas (CTCL). Large cell transformation of MF has been associated with disease progression and overall poor outcome. The expression of CD30, which defines anaplastic large cell lymphoma (ALCL) and lymphomatoid papulosis (LyP), might also occur in a subset of patients with MF, with or without large cell transformation. Brentuximab vedotin is an anti-CD30 monoclonal antibody which has been proven to be a safe and effective therapeutic agent in the treatment of CD30-positive lymphomas, such as Hodgkin lymphoma and ALCL...
May 27, 2018: Journal of Cutaneous Pathology
Y Y Xiong, Z J Liu, L Chen, F F Yuan, Q S Yin, R H Mi, B Zhang, J W Du, Q L Zhang, Q D Lin, L N Zhang, X Gao, L H Dong, Y F Li, Y P Song, X D Wei
Objective: To explore the clinical features of patients with synchronous lymphoma and carcinoma. Methods: The clinical data of 17 patients with Synchronous lymphoma and carcinoma from February 2012 to October 2017 were analyzed retrospectively. Results: Among 17 patients of lymphoma, 1 case HL, 2 cases B-NHL, 6 cases MZBL, 3 cases DLBCL, 1 case mantle cell lymphoma (MCL) , 3 cases NK/T- cell lymphoma, 1 case anaplastic large cell lymphoma(ALCL). In terms of 17 patients with carcinoma, 3 cases esophageal carcinoma, 3 cases gastric carcinoma, 2 cases colorectal carcinoma, 7 cases thyroid carcinoma, 1 case hepatocellular carcinoma and lung cancer...
April 14, 2018: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
Fabio Santanelli di Pompeo, Michail Sorotos
No abstract text is available yet for this article.
June 2018: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
Po-Shuan Huang, I-Hsiao Chung, Yang-Hsiang Lin, Tzu-Kang Lin, Wei-Jan Chen, Kwang-Huei Lin
Anaplastic lymphoma kinase (ALK)-negative anaplastic large-cell lymphoma (ALCL) is a rare type of highly malignant, non-Hodgkin lymphoma. Currently, only a few gene rearrangements have been linked to ALK-negative ALCL progression. However, the specific molecular mechanisms underlying the growth of ALK-negative ALCL tumors remain unclear. Here, we investigated aberrantly expressed, long non-coding RNAs (lncRNAs) in ALK-negative ALCL and assessed their potential biological function. MIR503HG ( miR-503 host gene) was highly expressed in ALK-negative cell lines and was significantly upregulated in tumors in mice formed from ALK-negative ALCL cell lines...
May 14, 2018: International Journal of Molecular Sciences
Tami D John, Swati Naik, Kathryn Leung, Ghadir Sasa, Caridad Martinez, Robert A Krance
Relapsed ALK-positive ALCL often is responsive to CRZ monotherapy. The subsequent role of allogeneic HCT after achieving second remission is poorly understood. We report 6 children who underwent allogeneic HCT for relapsed ALCL after CRZ. Age at transplant ranged from 10.7 to 22.6 years. Follow-up ranged from 0.9 to 4.5 years. All patients engrafted. Three of 4 patients that received a reduced-toxicity conditioning regimen containing fludarabine, alemtuzumab, and low-dose irradiation showed progressive mixed chimerism...
May 2, 2018: Pediatric Transplantation
Congjie Zhang, Fan Fan, Zhimin Wang, Jinshuai Song, Chunsen Li, Yirong Mo
1-Borabicyclo(1.1.0)but-2(3)-ene (1BB) is a singlet biradical with two single electrons which can form an ionic resonance structure via charge-shift. The ionic resonance structure is a B-heterocyclic carbene (BHC) which can act as carbene, Lewis base, L- and Z-type ligands to give adducts and complexes. Using a range of quantum methods, we designed four types of stable compounds (A-D) derived from 1BB. These compounds retain the unique features of 1BB. As a consequence, we investigated the structures, stability and Wiberg bond orders (WBIs) of the Lewis adducts of A-D with Lewis acids (BePh₂, BH₃, AlH₃, AlCl₃, C₅BH₅ and C₁₃BH₉), as well as the Cu(I), Ag(I) and Au(I) complexes...
May 1, 2018: Chemistry: a European Journal
Xu Yang, Kaiyuan Yu, Haoran Wang, Haiyang Zhang, Chongsheng Bai, Miao Song, Yanfei Han, Bing Shao, Yanfei Li, Xinwei Li
Exposure to aluminum (Al) inhibits bone formation, the principal mechanism possibly due to oxidative stress. However, little data is available that establishes the precise relationship. In this study, Wistar rats were exposed to 0 (GC), 0.4 (GL), 0.8 (GM) or 1.6 (GH) mg/L aluminum trichloride (AlCl3 ) in drinking water for 90 days, respectively. The concentrations of Al in serum and bone, serum markers of bone metabolism, bone mineral density (BMD) and body weight were measured. Histological changes within femurs were observed by H&E, ALP, and TRACP staining...
April 25, 2018: Food and Chemical Toxicology
Norbert Schmitz, Georg Lenz, Matthias Stelljes
Mature T-and natural killer cell (NK) - cell neoplasms comprise a group of morphologically, immunophenotypically, molecularly, and clinically heterogeneous disorders with generally unfavorable outcome. Results of first-line chemotherapy are unsatisfactory for the most common T-cell lymphomas (PTCL-NOS; AITL; ALCL, ALK-negative) as well as for many other entities. High-dose therapy followed by autologous hematopoietic stem cell transplantation is widely recommended for consolidation after a complete or partial remission is achieved...
April 26, 2018: Blood
Antonella Campanale, Rosaria Boldrini
No abstract text is available yet for this article.
May 2018: Plastic and Reconstructive Surgery
Maurizio Bruno Nava, Giuseppe Catanuto, Nicola Rocco
No abstract text is available yet for this article.
May 2018: Plastic and Reconstructive Surgery
Sandra Hudson, Dongliang Wang, Frank Middleton, Barbara H Nevaldine, Rana Naous, Robert E Hutchison
BACKGROUND: Anaplastic lymphoma kinase (ALK)-positive anaplastic large cell lymphoma (ALCL) shows 60-70% event free survival with standard treatments. Targeted therapies are being tested for increased benefit and/or reduced toxicity, but interactions with standard agents are not well known. METHODS: We exposed four ALCL cell lines to two targeted agents, crizotinib and brentuximab vedotin, and to two standard agents, doxorubicin and vinblastine. For each agent and combination, we measured apoptosis and expression of approximately 300 previously annotated genes of interest using targeted RNA-sequencing...
April 26, 2018: Pediatric Blood & Cancer
Marshall E Kadin, John Morgan, Haiying Xu, Alan L Epstein, David Sieber, Bradley A Hubbard, William P Adams, Carlos E Bacchi, Joao C S Goes, Mark W Clemens, L Jeffrey Medeiros, Roberto N Miranda
More than 500 women worldwide have developed a CD30+ T-cell lymphoma around breast implants, strongly suggesting a cause and effect relationship, and designated as breast implant-associated anaplastic large cell lymphoma (BIA-ALCL). The mechanism of lymphomagenesis is unknown. Recently, a bacterial biofilm containing gram negative bacilli was discovered on the surface of breast implants associated with ALCL. We and others have described overexpression of the proto-oncogene JUNB and mutations of JAK1/2, TP53 and STAT3 in BIA-ALCL...
April 21, 2018: Human Pathology
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