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https://www.readbyqxmd.com/read/29053547/primary-cutaneous-sarcomatoid-anaplastic-lymphoma-kinase-positive-anaplastic-large-cell-lymphoma-with-linear-distributional-lesions
#1
Hao Chen, Jing-Shu Xiong, Nan Sheng, Wen-Kai Zong, Yi-Hua Wang, Min Li, Jian-Fang Sun
We report a case of cutaneous anaplastic lymphoma kinase-positive anaplastic large-cell lymphoma (ALCL) with linear distributional lesions and sarcomatoid histologic features. A sarcomatoid variant is the rarest morphological pattern of ALCL. Interestingly, the morphology of tumor cells in the present case transitioned from a sarcomatoid variant of ALCL at first diagnosis to a classic variant at relapse. The case is a diagnostic challenge considering both the clinical and histologic aspects. Awareness of the sarcomatoid variant of ALCL and its morphological changes can lead to a correct diagnosis...
November 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29049466/breast-implant-associated-anaplastic-large-cell-lymphoma-a-systematic-review
#2
Ashley N Leberfinger, Brittany J Behar, Nicole C Williams, Kevin L Rakszawski, John D Potochny, Donald R Mackay, Dino J Ravnic
Importance: Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL), a rare peripheral T-cell lymphoma, is increasing in incidence. However, many practitioners who treat patients with breast cancer are not aware of this disease. Objectives: To assess how BIA-ALCL develops, its risk factors, diagnosis, and subsequent treatment and to disseminate information about this entity to the medical field. Evidence Review: A literature review was performed in an academic medical setting...
October 18, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/29040370/long-term-safety-of-textured-and-smooth-breast-implants
#3
M Bradley Calobrace, Michael R Schwartz, Kamakshi R Zeidler, Troy A Pittman, Robert Cohen, W Grant Stevens
In this review, the authors provide a 20-year review and comparison of implant options and describe the evolution of breast implant surface textures; compare available implant surfaces; present long-term safety data from the 10-year US-based Core clinical studies; list the key benefits and risks associated with smooth and textured implants; and provide perspectives on breast implant-associated anaplastic large cell lymphoma (BIA-ALCL). The authors explore the key benefits and risks associated with all available devices so that optimal and safe patient outcomes can be achieved...
September 28, 2017: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/29036945/what-s-your-micromort-a-patient-oriented-analysis-of-breast-implant-associated-anaplastic-large-cell-lymphoma-bia-alcl
#4
David A Sieber, William P Adams
Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) continues to be a rare and elusive malignancy. Because BIA-ALCL does not behave like traditional lymphomas, additional research needs to be conducted to further delineate the lymphoproliferative nature of BIA-ALCL. An estimated 35 million women worldwide have breast implants and the total reported deaths from BIA-ALCL is 12 to date. The term micromort was introduced in 1979 by Ronald Howard as a person's risk of dying as 1 in a million. Drinking 0...
September 1, 2017: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/29036941/breast-implant-associated-anaplastic-large-cell-lymphoma-in-a-transgender-woman
#5
Mintsje de Boer, Wouter B van der Sluis, Jan P de Boer, Lucy I H Overbeek, Flora E van Leeuwen, Hinne A Rakhorst, René R W J van der Hulst, Nathalie J Hijmering, Mark-Bram Bouman, Daphne de Jong
Breast implant-associated anaplastic large-cell lymphoma (BIA-ALCL) is a rare but serious complication in patients with breast implants, Patients are at risk of BIA-ALCL whether they receive breast implants for cosmetic reasons or for reconstructive purposes after surgery for breast cancer or prophylactic mastectomy. During the past decade, an increased number of reports have addressed BIA-ALCL. Herein, we describe BIA-ALCL in a transgender woman. The patient received breast implants as part of her gender transition and was diagnosed with BIA-ALCL 20 years later...
September 1, 2017: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/29035291/from-pathology-to-precision-medicine-in-anaplastic-large-cell-lymphoma-expressing-anaplastic-lymphoma-kinase-alk-alcl
#6
REVIEW
Michael T Werner, Qian Zhang, Mariusz A Wasik
Anaplastic large cell lymphoma expressing anaplastic lymphoma kinase (ALK+ ALCL) is a distinct subtype of non-Hodgkin lymphoma. In this review, we discuss the historical findings that led to its classification as a unique disease, despite its varied clinical presentation and histology. We discuss the molecular mechanisms underlying ALK+ ALCL pathology and the questions that remain in the field. Finally, we visit how decades of ALK+ ALCL research has yielded more precise drugs that hold promise for the future...
October 16, 2017: Cancers
https://www.readbyqxmd.com/read/29030834/prognostic-impact-of-minimal-disseminated-disease-and-immune-response-to-npm-alk-in-japanese-children-with-alk-positive-anaplastic-large-cell-lymphoma
#7
Yuka Iijima-Yamashita, Tetsuya Mori, Atsuko Nakazawa, Reiji Fukano, Tetsuya Takimoto, Masahito Tsurusawa, Ryoji Kobayashi, Keizo Horibe
The prognostic impact of minimal disseminated disease (MDD) and anti-anaplastic lymphoma kinase (ALK) antibody titer in children with ALK-positive anaplastic large cell lymphoma (ALCL) was reported by an Italian/German group. Here, we examine their prognostic value in Japanese children with ALK-positive ALCL. We evaluated nucleophosmin (NPM)-ALK transcripts in 60 patients at diagnosis by RT-PCR and real-time PCR (qPCR). The antibody titer was assessed in 35 patients. Fifty-two percent were MDD positive by RT-PCR and 37% had more than 10 copies of NPM-ALK per 10(4) copies of ABL (10NCNs) by qPCR...
October 13, 2017: International Journal of Hematology
https://www.readbyqxmd.com/read/29025239/response-to-breast-implant-associated-anaplastic-large-cell-lymphoma-bia-alcl-why-the-search-for-an-infectious-etiology-may-be-irrelevant
#8
Anand K Deva
No abstract text is available yet for this article.
October 1, 2017: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/29025238/breast-implant-associated-anaplastic-large-cell-lymphoma-bia-alcl-why-the-search-for-an-infectious-etiology-may-be-irrelevant
#9
Eric Swanson
No abstract text is available yet for this article.
October 1, 2017: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/28984455/mechanistic-insights-into-the-alternating-copolymerization-of-epoxides-and-cyclic-anhydrides-using-a-salph-alcl-and-iminium-salt-catalytic-system
#10
Megan E Fieser, Maria J Sanford, Lauren A Mitchell, Christine R Dunbar, Mukunda Mandal, Nathan J Van Zee, Devon M Urness, Christopher J Cramer, Geoffrey W Coates, William B Tolman
Mechanistic studies involving synergistic experiment and theory were performed on the perfectly alternating copolymerization of 1-butene oxide and carbic anhydride using a (salph)AlCl/[PPN]Cl catalytic pair. These studies showed a first-order dependence of the polymerization rate on the epoxide, a zero-order dependence on the cyclic anhydride, and a first-order dependence on the catalyst only if the two members of the catalytic pair are treated as a single unit. Studies of model complexes showed that a mixed alkoxide/carboxylate aluminum intermediate preferentially opens cyclic anhydride over epoxide...
October 6, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28975123/systemic-and-primary-cutaneous-anaplastic-large-cell-lymphoma-clinical-features-morphological-spectrum-and-immunohistochemical-profile
#11
Kanwardeep Singh Kwatra, Preethi A M Paul, Nalini Calton, Joseph M John, James D Cotelingam
BACKGROUND: T-cell lymphomas with anaplastic morphology typically comprise of anaplastic lymphoma kinase positive, anaplastic large cell lymphoma (ALK+ ALCL), ALK-negative ALCL (ALK- ALCL), and primary cutaneous ALCL (PC-ALCL). However, other entities such as diffuse large B-cell lymphoma, peripheral T-cell lymphoma, Hodgkin lymphoma, and undifferentiated carcinoma can also show similar anaplastic features. AIMS: To study the clinical features and histological spectrum of ALCL and emphasize the role of immunohistochemistry (IHC) in their diagnosis and categorization...
July 2017: South Asian Journal of Cancer
https://www.readbyqxmd.com/read/28974506/five-year-results-of-brentuximab-vedotin-in-patients-with-relapsed-or-refractory-systemic-anaplastic-large-cell-lymphoma
#12
Barbara Pro, Ranjana Advani, Pauline Brice, Nancy L Bartlett, Joseph D Rosenblatt, Tim Illidge, Jeffrey Matous, Radhakrishnan Ramchandren, Michelle Fanale, Joseph M Connors, Keenan Fenton, Dirk Huebner, Juan M Pinelli, Dana A Kennedy, Andrei Shustov
This pivotal phase 2 study evaluated the safety and efficacy of brentuximab vedotin in patients with relapsed or refractory systemic anaplastic large cell lymphoma (ALCL). After a median observation period of approximately 6 years from first treatment, we examined the durability of remission, progression-free survival (PFS), overall survival (OS), and safety outcomes of patients treated on this trial. Among all enrolled patients (N=58), no progressions were observed beyond 40 months, and median OS was not reached...
October 3, 2017: Blood
https://www.readbyqxmd.com/read/28958772/recommendations-for-the-optimal-radiation-dose-in-patients-with-primary-cutaneous-anaplastic-large-cell-lymphoma-a-report-of-the-dutch-cutaneous-lymphoma-group
#13
Rutger C Melchers, Rein Willemze, Laurien A Daniëls, Karen J Neelis, Marcel W Bekkenk, Ellen R M de Haas, Barbara Horvath, Michelle M van Rossum, Cornelus J G Sanders, Berit Velstra, Joep C J M Veraart, Rachel E J Roach, Maarten H Vermeer, Koen D Quint
PURPOSE: To determine the optimal radiation dose for treatment of primary cutaneous anaplastic large cell lymphoma (C-ALCL) with solitary or localized, multifocal or recurrent skin lesions. METHODS AND MATERIALS: In this multicenter study, patients with C-ALCL who had been treated with radiation therapy (RT) between 1984 and 2016 were retrieved from the Dutch registry of cutaneous lymphomas. Distinction was made between patients first presenting with solitary or localized lesions (n=63), with multifocal skin lesions (n=6), and patients with a skin relapse (n=22)...
August 24, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28942227/case-report-breast-seroma-mimicking-breast-implants
#14
Amalie Sylvester-Hvid, Magnus B Avnstorp, Lene Wagenblast, Jørgen Lock-Andersen, Steen H Matzen
Introduction Breast seroma may be caused by a variety of factors including lymphatic disruption, continuous inflammation and foreign bodies such as breast implants. In cases of breast implants associated seroma the diagnosis of Anaplastic Large Cell Lymphoma (ALCL) should be investigated. Presentation of Case A 45-year-old Caucasian woman was referred with bilateral swelling of the breasts causing tension and pain. MRI showed accumulations compatible with bilateral silicone implants. Ultrasound-guided aspiration showed no malignancy or silicone...
September 4, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28938347/global-adverse-event-reports-of-breast-implant-associated-alcl-an-international-review-of-40-government-authority-databases
#15
Damián Palafox
No abstract text is available yet for this article.
September 16, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28938345/re-letter-to-editor-for-global-adverse-event-reports-of-breast-implant-associated-alcl-an-international-review-of-40-government-authority-databases-plast-reconst-surg-2017-139-1029-1039
#16
https://www.readbyqxmd.com/read/28915212/22-cases-of-bia-alcl-awareness-and-outcome-tracking-from-the-italian-ministry-of-health
#17
Campanale Antonella, Boldrini Rosaria, Marletta Marcella
BACKGROUND: To date, 359 cases of anaplastic large cell lymphoma in women with breast implants (BIA-ALCL) worldwide have been reported out of more than 10 million implanted patients but Health Care Authorities suspect this is a possible underestimation and the limited number of cases makes it difficult to clarify its etiology. The General Directorate of Medical Devices and Pharmaceutical Services of the Italian Ministry of Health (IMoH) has examined and studied the Italian BIA-ALCL cases, and the aim of this study is to report on the knowledge and experience gained on this new emerging disease...
September 13, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28895885/anaplastic-lymphoma-kinase-in-cutaneous-malignancies
#18
REVIEW
Severine Cao, Vinod E Nambudiri
Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase that has been implicated in the pathogenesis of a variety of neoplasms. As suggested by its name, ALK was first described as part of a translocation product in cases of anaplastic large-cell lymphoma, with other genetic and cytogenetic ALK mutations subsequently coming to attention in the development of many other hematologic and solid organ malignancies. ALK has now been shown to play a role in the pathogenesis of several cutaneous malignancies, including secondary cutaneous systemic anaplastic large-cell lymphoma (ALCL) and primary cutaneous ALCL, melanoma, spitzoid tumors, epithelioid fibrous histiocytoma, Merkel cell carcinoma, and basal cell carcinoma...
September 12, 2017: Cancers
https://www.readbyqxmd.com/read/28841597/macrotextured-breast-implants-with-defined-steps-to-minimize-bacterial-contamination-around-the-device-experience-in-42-000-implants
#19
William P Adams, Eric J Culbertson, Anand K Deva, Mark R Magnusson, Craig Layt, Mark L Jewell, Patrick Mallucci, Per Hedén
BACKGROUND: Bacteria/biofilm on breast implant surfaces has been implicated in capsular contracture and breast implant-associated anaplastic large-cell lymphoma (ALCL). Macrotextured breast implants have been shown to harbor more bacteria than smooth or microtextured implants. Recent reports also suggest that macrotextured implants are associated with a significantly higher incidence of breast implant-associated ALCL. Using techniques to reduce the number of bacteria around implants, specifically, the 14-point plan, has successfully minimized the occurrence of capsular contracture...
September 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28821506/crizotinib-has-antitumor-activity-in-alk-positive-alcl-and-imt
#20
(no author information available yet)
Crizotinib has an overall response rate of 90% in ALCL and 86% in IMT at the recommended phase II dose.
August 18, 2017: Cancer Discovery
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