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Maayan Yitshak Sade

Viktoria Leikin-Zach, Eilon Shany, Maayan Yitshak-Sade, Ron Eshel, Tali Shafat, Avraham Borer, Rimma Melamed
BACKGROUND: Extended-spectrum beta-lactamase (ESBL) production is the most common antimicrobial resistance mechanism in the neonatal intensive care unit (NICU), with colonization and blood stream infections being a major threat to this population. Since 2013, all NICU admissions at our facility were screened twice weekly for ESBL colonization. OBJECTIVES: To determine independent risk factors for colonization of infants with ESBL-producing bacteria in the NICU. METHODS: A retrospective case study of ESBL-colonized infants vs...
May 2018: Israel Medical Association Journal: IMAJ
Noa Zimhony, Ibrahim Abu-Salameh, Iftach Sagy, Yotam Dizitzer, Liat Oxman, Maayan Yitshak-Sade, Victor Novack, Anat Horev, Gal Ifergane
BACKGROUND: Previous studies have not shown any significant effect on stroke incidence during Ramadan. We aimed to investigate the association between ischemic stroke incident hospitalizations and Ramadan, accounting for seasonality and temperature. METHODS AND RESULTS: This retrospective cohort study included all patients admitted with acute ischemic stroke to Soroka University Medical Center from June 2012 to June 2016. We obtained daily mean temperatures and relative humidity rates from 2 monitoring stations in South Israel...
May 3, 2018: Journal of the American Heart Association
Sagi Shashar, Maayan Yitshak-Sade, Roman Sonkin, Victor Novack, Eli Jaffe
BACKGROUND: Published annual estimates report a global burden of 2.5 million snakebite cases and >100,000 deaths. In Israel, envenomations are the third most frequent cause of poisonings that are of moderate to major clinical severity. Most studies focus on the clinical descriptions of snakebites in tropical climates, and we sought to investigate the association between snakebite frequency and meteorological parameters. OBJECTIVE: We sought to investigate the seasonality of snakebites and evaluate the association between increasingly common heat waves and other meteorological parameters and snakebite frequency in a semiarid nontropical climate...
June 2018: Journal of Emergency Medicine
Limor Besser, Liat Sabag-Shaviv, Maayan Yitshak-Sade, Salvatore Andrea Mastrolia, Danielle Landau, Ruthy Beer-Weisel, Vered Klaitman, Neta Benshalom-Tirosh, Moshe Mazor, Offer Erez
OBJECTIVE: In the last few decades, attention has been focused on morbidity and mortality associated with late preterm delivery (34-36 + 6/7 weeks), accounting for 60-70% of all preterm births. This study is aimed to determine (1) the prevalence of late preterm deliveries (spontaneous and medically indicated) in our population; and (2) the rate of neonatal morbidity and mortality as well as maternal complications associated with the different phenotypes of late preterm deliveries...
April 26, 2018: Journal of Maternal-fetal & Neonatal Medicine
Gil Zeevi, Dan Tirosh, Joel Baron, Maayan Yitshak Sade, Adi Segal, Reli Hershkovitz
OBJECTIVE: To (a) evaluate the risk for placenta accreta following primary cesarean section (CS), in regard to the stage of labor, the cesarean section was taken (elective prelabor vs. unplanned during labor); and (b) investigate whether the association between placenta accreta and maternal and neonatal complications is modified by the type of the primary CS. STUDY DESIGN: In a population-based retrospective cohort study, we included all singleton deliveries occurred in Soroka University Medical Center between 1991 and 2015, of women who had a history of a single CS...
May 2018: Archives of Gynecology and Obstetrics
Noa A Brzezinski-Sinai, Moshe Stavsky, Tal Rafaeli-Yehudai, Maayan Yitshak-Sade, Isaac Brzezinski-Sinai, Majdi Imterat, Salvatore Andrea Mastrolia, Offer Erez
OBJECTIVES: To analyze in a retrospective cohort study the outcomes of pregnancies with isolated oligohydramnios at the late preterm period (34-36.6 weeks of gestation). STUDY DESIGN: This retrospective cohort study included three groups of women: (1) Women with isolated oligohydramnios whose pregnancy was managed conservatively (n = 33 births); (2) women with isolated oligohydramnios who were managed actively (i.e. induction of labor) (n = 111 births); and (3) a control group including women with normal amount of amniotic fluid who had a spontaneous late preterm delivery (n = 10,445 births)...
February 1, 2018: Journal of Maternal-fetal & Neonatal Medicine
Maayan Yitshak-Sade, Itai Kloog, Victor Novack
BACKGROUND: Numerous studies show associations between exposure to Particulate Matter and Cardiovascular disease (CVD). Current cardiovascular equations incorporate the major risk factors for CVD. The patients' environment, however, is not incorporated in these equations. METHODS: In a retrospective analysis, we assessed the contribution of neighborhood greenness and particulate matter (coarse-PM and PM<2.5μm-PM2.5 ) to the development of CVD by analyzing the change in prediction abilities...
October 2017: Environment International
Maayan Yitshak-Sade, Lena Novack, Daniella Landau, Itai Kloog, Batia Sarov, Reli Hershkovitz, Isabella Karakis
BACKGROUND: Air pollution and meteorology exposures during pregnancy have been suggested to be associated with Birth Weight (BW). Yet, the individual medical background and close household environment is rarely addressed. We aimed to evaluate the independent association of BW with meteorological and air pollution exposures during pregnancy, in addition to individual, parental and household risk factors, among the Bedouin-Arab population in Southern Israel; a semi nomadic population, featured by low socio-economic levels and poor housing and household environment...
October 2016: Chemosphere
Maayan Yitshak Sade, Itai Kloog, Idit F Liberty, Joel Schwartz, Victor Novack
CONTEXT: Evidence from recent decades supports a causal association between air pollution (particulate matter <10 μm in diameter [PM10] and PM <2.5 μm in diameter [PM2.5]) and oxidative stress, possibly involving impaired metabolism of glucose and lipids. OBJECTIVE: Using a satellite based model to assess PM exposure at 1-km spatial resolution, we examined the associations between PM and glucose, hemoglobin A1c (HbA1c), and lipids. DESIGN: Population-based retrospective cohort study of a 10-year period...
June 2016: Journal of Clinical Endocrinology and Metabolism
Moshe Stavsky, Renana Robinson, Maayan Yitshak Sade, Hanah Krymko, Eli Zalstein, Viktorya Ioffe, Victor Novack, Aviva Levitas
BACKGROUND: The aetiology of conotruncal heart defects is poorly understood and the birth prevalence varies geographically. The known risk factors for developing conotruncal heart defects are as follows: CHD in siblings, genetic chromosomal abnormalities, paternal age >30 years, high parity, low birth weight, prematurity, and maternal diabetes. OBJECTIVE: The aim of this study was to characterise conotruncal heart defects, birth prevalence, mortality, and morbidity in the population of southern Israel, of whom 75% are Jewish and the rest are mostly Bedouin Arabs...
January 2017: Cardiology in the Young
Maayan Yitshak Sade, Victor Novack, Gal Ifergane, Anat Horev, Itai Kloog
BACKGROUND AND PURPOSE: Studies have demonstrated consistent associations between cardiovascular illness and particulate matter (PM) <10 and <2.5 μm in diameter, but stroke received less attention. We hypothesized that air pollution, an inflammation progenitor, can be associated with stroke incidence in young patients in whom the usual risk factors for stroke are less prevalent. We aimed to evaluate the association between stroke incidence and exposure to PM <10 and <2.5 μm, in a desert area characterized by a wide range of PM...
December 2015: Stroke; a Journal of Cerebral Circulation
Maayan Yitshak Sade, Yair Zlotnik, Itai Kloog, Victor Novack, Chava Peretz, Gal Ifergane
The risk for developing Parkinson's disease (PD) is a combination of multiple environmental and genetic factors. The Negev (Southern Israel) contains approximately 252.5 km(2) of agricultural cultivated fields (ACF). We aimed to estimate the prevalence and incidence of PD and to examine possible geographical clustering and associations with agricultural exposures. We screened all "Clalit" Health Services members in the Negev (70% of the population) between the years 2000 and 2012. Individual demographic, clinical, and medication prescription data were available...
2015: Parkinson's Disease
Iris Raz, Lena Novack, Maayan Yitshak-Sade, Yemima Shahar, Arnon Wiznitzer, Ruslan Sergienko, Lora Warshawsky-Livne
In view of the growing proportion of "non-urgent" admissions to obstetric emergency rooms (OERs) and recent changes in copayment policies for OER visits in Israel, we assessed factors contributing to OER overcrowding. The changes investigated were (a) exemption from copayment for women with birth contractions, (b) allowing phone referrals to the OER and (c) exemption from copayment during primary care clinic closing hours. We analyzed data of a large tertiary hospital with 37 deliveries per day. Counts of women discharged to home from the OER were an indicator of "non-urgent" visits...
October 2015: Health Policy
Maayan Yitshak-Sade, Nadav Davidovitch, Lena Novack, Itamar Grotto
OBJECTIVE: Recent years have seen a global trend of declining immunization rates of recommended vaccines that is more pronounced among school-age children. Ethnic disparities in child immunization rates have been reported in several countries. We investigated an effect of ethnicity on the vaccination rates of immunizations routinely administered within schools in Israel. DESIGN: Data were collected from the Ministry of Health database regarding immunization coverage for all registered Israeli schools (3736) in the years 2009-2011...
October 2016: Ethnicity & Health
Omer Mor, Moshe Stavsky, Maayan Yitshak-Sade, Salvatore Andrea Mastrolia, Ruthy Beer-Weisel, Tal Rafaeli-Yehudai, Limor Besser, Batel Hamou, Moshe Mazor, Offer Erez
BACKGROUND: Cerebral palsy (CP) is a late sequel of pregnancy, and the role of preeclampsia is debatable. OBJECTIVE: The aims of this study were to determine the association between preeclampsia and cerebral palsy and to determine the risk factors for the development of cerebral palsy in these patients. STUDY DESIGN: A retrospective population-based cohort study was designed that included 229,192 singleton pregnancies. The study population was divided into 2 groups: (1) patients with preeclampsia (n = 9749) and (2) normotensive gestations (n = 219,443)...
January 2016: American Journal of Obstetrics and Gynecology
Lena Novack, Esther Manor, Elena Gurevich, Maayan Yitshak-Sade, Daniella Landau, Batia Sarov, Reli Hershkovitz, Doron Dukler, Tali Vodonos, Isabella Karakis
Environmental hazards were shown to have an impact on cell proliferation (CP). We investigated CP of lymphocytes in umbilical cord blood in relation to prenatal environmental exposures in a sample of 346 Arab-Bedouin women giving birth in a local hospital. Information on subjects' addresses at pregnancy, potential household exposures and demographical status was collected in an interview during hospitalization. This population is usually featured by high rates of neonatal morbidity and multiple environmental exposures, originating from the local industrial park (IP), household hazards and frequent male smoking...
2015: SpringerPlus
Maayan Yitshak Sade, Itai Kloog, Idit F Liberty, Itzhak Katra, Lena Novack, Victor Novack
Recent studies demonstrated an adverse effect of chronic exposure to air pollution (AP) on metabolic syndrome and its components. In a population-based study, we investigated the association between exposure to ambient AP and serum glucose (SG), among subjects with normal glucose, impaired fasting glucose (IFG), and diabetes mellitus (DM).We included 1,063,887 SG tests performed in 131,882 subjects (years 2001-2012). Exposure data included daily levels of SO2, NO2 and other pollutants of industrial, traffic, and nonanthropogenic sources...
July 2015: Medicine (Baltimore)
Maayan Yitshak-Sade, Rafael Gorodischer, Micha Aviram, Lena Novack
Fetal exposure to H2 blockers (H2 Bs) or proton pump inhibitors (PPIs) has been reported to be associated with asthma in children. We evaluated the risk of asthma in offspring following prenatal H2 Bs. We enrolled 91 428 children and their mothers who resided in southern Israel during 1998-2011. The computerized medications database was linked with records from the district hospital. Of the eligible children, 11 227 developed asthma, and overall 5.5% had been exposed to H2 Bs or PPIs prenatally. The risk of developing asthma was slightly higher in the group exposed to H2 Bs or PPIs (RR, 1...
January 2016: Journal of Clinical Pharmacology
Isabella Karakis, Daniella Landau, Maayan Yitshak-Sade, Reli Hershkovitz, Michal Rotenberg, Batia Sarov, Itamar Grotto, Lena Novack
BACKGROUND: The Bedouin-Arab population in Israel comprises a low socio-economic society in transition. Smoking among males and consanguineous marriages are frequent. A previous study showed elevated rates of major malformations within groups from this population residing near an industrial park, where high ambient values of arsenic (As) and nickel (Ni) were detected, compared to groups living in remote localities. OBJECTIVES: We estimated the extent of exposure to metals in pregnant Bedouin-Arab women in relation to congenital malformations...
June 1, 2015: Science of the Total Environment
Maayan Yitshak-Sade, Victor Novack, Itzhak Katra, Rafael Gorodischer, Asher Tal, Lena Novack
Air pollution has been shown to increase frequency of asthma attacks, as usually measured by hospitalisation rates. We hypothesise that purchase of asthma reliever medications will reflect a broader association between the environmental exposure and asthma exacerbations. In a time series analysis, we estimated the association of dust storms with mild asthma manifestations, as indicated by medication purchases, during 2005-2011. We compared our results with the estimation of the association of dust storms with hospitalisations due to asthma and asthma-like symptoms...
March 2015: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
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