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https://www.readbyqxmd.com/read/29284137/grapefruit-and-its-biomedical-antigenotoxic-and-chemopreventive-properties
#1
REVIEW
José Melesio Cristóbal-Luna, Isela Álvarez-González, Eduardo Madrigal-Bujaidar, Germán Chamorro Cevallos
Grapefruit (Citrus paradisi Mcfad) is a perenifolium tree 5-6 m high with a fruit of about 15 cm in diameter, protected by the peel we can find about 11-14 segments (carpels), each of which is surrounded by a membrane and each containing the juice sacs, as well as the seeds. The fruit is made up of numerous compounds, and is known to have nutritive value because of the presence of various vitamins and minerals, among other chemicals. The fruit is also used in the field of gastronomy. Information has been accumulated regarding the participation of the fruit structures in a variety of biomedical, antigenotoxic and chemopreventive effects, surely related with the presence of the numerous chemicals that have been determined to constitute the fruit...
December 25, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29235025/effects-of-exposure-to-malathion-on-blood-glucose-concentration-a-meta-analysis
#2
Marco Antonio Ramirez-Vargas, Eugenia Flores-Alfaro, Mayrut Uriostegui-Acosta, Patricia Alvarez-Fitz, Isela Parra-Rojas, Ma Elena Moreno-Godinez
Exposure to malathion (an organophosphate pesticide widely used around the world) has been associated with alterations in blood glucose concentration in animal models. However, the results are inconsistent. The aim of this meta-analysis was to evaluate whether malathion exposure can disturb the concentrations of blood glucose in exposed rats. We performed a literature search of online databases including PubMed, EBSCO, and Google Scholar and reviewed original articles that analyzed the relation between malathion exposure and glucose levels in animal models...
December 12, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29202842/preclinical-and-clinical-aspects-of-tnf-%C3%AE-and-its-receptors-tnfr1-and-tnfr2-in-breast-cancer
#3
REVIEW
Isela Martínez-Reza, Lorenza Díaz, Rocío García-Becerra
Breast cancer is the most common malignancy in women and a public health problem worldwide. Breast cancer is often accompanied by an inflammatory process characterized by the presence of proinflammatory cytokines such as tumor necrosis factor (TNF-α), which has important implications in the course of the disease. Inflammation has been described primarily as a favorable environment for tumor development. However, under certain conditions TNF-α can promote signals for activation, differentiation, survival or cell death, so the study of the variants of this cytokine, its receptors, the presence of polymorphisms and its implication in different phenotypes of breast cancer is necessary...
December 4, 2017: Journal of Biomedical Science
https://www.readbyqxmd.com/read/29187287/association-between-leptin-and-disease-activity-in-patients-with-rheumatoid-arthritis
#4
José Antonio de Jesús Batún-Garrido, Marisol Salas-Magaña, Isela Esther Juárez-Rojop, Eúfrates Hernández-Núñez, Francisco Olán
BACKGROUND AND OBJECTIVE: Multiple studies have found a direct relationship between leptin concentrations and disease activity in rheumatoid arthritis. PATIENTS AND METHODS: We studied 77 patients with the diagnosis of rheumatoid arthritis; the leptin determination was through an enzyme immunoassay. Disease activity was assessed by the DAS-28 CRP. A multivariate logistic regression model was used to determine the association between significant variables and leptin concentrations...
November 26, 2017: Medicina Clínica
https://www.readbyqxmd.com/read/29101672/association-between-leptin-and-il-6-concentrations-with-cardiovascular-risk-in-patients-with-rheumatoid-arthritis
#5
José Antonio De Jesús Batún-Garrido, Marisol Salas-Magaña, Isela Esther Juárez-Rojop
Pro-inflammatory cytokines such as leptin and IL-6 play an important role in the development of cardiovascular risk. Determine the relationship between leptin and IL-6 concentrations with cardiovascular risk in patients with rheumatoid arthritis. We determined IL-6 and leptin levels in 77 patients with the diagnosis of rheumatoid arthritis. The cardiovascular risk was calculated using the modified Framingham scale. Statistical analysis was performed using SPSS 22 considering a significant p < 0.05. Serum leptin concentrations and cardiovascular risk (CVR) factors were compared and found that there was a significant difference between higher leptin values and disease activity (p 0...
November 3, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/29090355/microbiological-comparison-of-blood-culture-and-amplification-of-16s-rdna-methods-in-combination-with-dgge-for-detection-of-neonatal-sepsis-in-blood-samples
#6
Isela García-Gudiño, Eucario Yllescas-Medrano, Rolando Maida-Claros, Diana Soriano-Becerril, Nestor F Díaz, Guadalupe García-López, Anayansí Molina-Hernández, Oscar Flores-Herrera, Francisco J Zavala-Díaz de la Serna, María Del Rosario Peralta-Pérez, Héctor Flores-Herrera
It is estimated that 15% of all newborns admitted to the neonatal intensive care unit (NICU) for suspected sepsis receive multiple broad-spectrum antibiotics without pathogen identification. The gold standard for bacterial sepsis detection is blood culture, but the sensitivity of this method is very low. Recently, amplification and analysis of the 16S ribosomal DNA (rDNA) bacterial gene in combination with denaturing gradient gel electrophoresis (DGGE) has proven to be a useful approach for identifying bacteria that are difficult to isolate by standard culture methods...
October 31, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29049139/the-role-of-the-cys23ser-rs6318-polymorphism-of-the-htr2c-gene-in-suicidal-behavior-systematic-review-and-meta-analysis
#7
Thelma B González-Castro, Yazmín Hernandez-Diaz, Isela E Juárez-Rojop, Lilia López-Narváez, Carlos A Tovilla-Zárate, José M Rodriguez-Perez, Juan P Sánchez-de la Cruz
The polymorphisms of the serotonin receptor 2C (HTR2C) gene have been proposed to influence suicidal behavior. The aim of our study was to explore the role of the HTR2C gene variant Cys23Ser (rs6318) in the pathogenesis of suicidal behavior through a systematic review and meta-analysis. The search was performed using EBSCO and PubMed databases. To be included in the analysis, the studies had to evaluate suicidal behavior (attempted, ideation, or completed suicide). The results of the meta-analysis were expressed as odds ratios (ORs)...
December 2017: Psychiatric Genetics
https://www.readbyqxmd.com/read/29035935/prevalence-and-correlations-between-suicide-attempt-depression-substance-use-and-functionality-among-patients-with-limb-amputations
#8
Pedro I Arias Vázquez, Rosa G Castillo Avila, Mayra Del C Dominguez Zentella, Yazmín Hernández-Díaz, Thelma B González-Castro, Carlos A Tovilla-Zárate, Isela E Juárez-Rojop, María L López-Narváez, Ana Frésan
Most patients undergoing limb amputations suffer significant emotional changes. The aim of this study was to estimate the prevalence of suicide attempts and depression in a sample of Mexican patients with limb amputations and, second, to determine whether the patients' functionality correlates with the presence of depression. We studied 40 patients who had undergone a limb amputation. The suicide attempt was evaluated using the Suicide Intent Scale. The depression was assessed using the Hamilton Depression Rating Scale, whereas the functionality of the patients was measured using the Functional Independence Measure...
October 13, 2017: International Journal of Rehabilitation Research. Revue Internationale de Recherches de Réadaptation
https://www.readbyqxmd.com/read/29035840/characteristics-of-mexican-children-and-adolescents-who-died-by-suicide-a-study-of-psychological-autopsies
#9
Thelma Beatriz González-Castro, Carlos Alfonso Tovilla-Zárate, Yazmín Hernández-Díaz, Isela E Juárez-Rojop, Alejandra Giovanna León-Garibay, Crystell Guadalupe Guzmán-Priego, Lilia López-Narváez, Ana Frésan
OBJECTIVE: In recent years, suicide in children and adolescents has increased considerably, becoming the second cause of death in this age group. Therefore, the aim of this study was to identify characteristics and factors that could precipitate deaths by suicide in children and adolescents. METHODS: Using the psychological autopsy method, we studied 28 suicide cases of children and adolescents between 10 and 17 years old. Socio-demographic factors, characteristics of the suicide and family history were documented...
October 13, 2017: Journal of Forensic and Legal Medicine
https://www.readbyqxmd.com/read/28992550/gender-differences-of-suicides-in-children-and-adolescents-analysis-of-167-suicides-in-a-mexican-population-from-2003-to-2013
#10
Daniela Georgina Aguilar-Velázquez, Thelma Beatriz González-Castro, Carlos Alfonso Tovilla-Zárate, Isela E Juárez-Rojop, Maria Lilia López-Narváez, Ana Frésan, Yazmin Hernández-Díaz, Crystell Guadalupe Guzmán-Priego
Suicide is the second cause of death in youth population. The aim of the present study was to analyze demographic characteristics and suicide methods used, as well as to identify gender differences among Mexican children and adolescents (aged 10-17 years) that committed suicide. Between January 2003 and December 2013, 167 suicides of children and adolescents between 10 and 17 years of age were documented by the Secretary of Health of the state of Tabasco, Mexico. All sociodemographic characteristics were compared according to gender...
December 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28971662/wavelength-coded-volume-holographic-imaging-endoscope-for-multidepth-imaging
#11
Isela D Howlett, Wanglei Han, Photini Rice, Jennifer K Barton, Raymond K Kostuk
A wavelength-coded volume holographic imaging (WC-VHI) endoscope system capable of simultaneous multifocal imaging is presented. The system images light from two depths separated by 100  μm in a tissue sample by using axial chromatic dispersion of a gradient index probe in combination with two light-emitting diode sources and a multiplexed volume hologram to separate the images. This system is different from previous VHI systems in that it uses planar multiplexed gratings and does not require curved holographic gratings...
October 2017: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/28967446/-production-of-infectious-units-of-isaria-fumosorosea-hypocreales-cordycipitaceae-from-different-indigenous-isolates-of-northeastern-mexico-using-3-propagation-strategies
#12
Fatima L Gandarilla-Pacheco, Lilia H Morales-Ramos, Benito Pereyra-Alférez, Myriam Elías-Santos, Isela Quintero-Zapata
The aim of this study was to evaluate the production of blastospores and conidia of different native isolates and a strain of Isaria fumosorosea using different propagation techniques. Two liquid culture media of casamino acids and peptone as nitrogen sources and glucose as carbon source for both media cultures were respectively used in the production of blastospores, while for the production of conidia, the fungi were grown in potato dextrose agar; from these cultures, solutions of conidia to a concentration of 1×10(6) per milliliter were prepared to inoculate flasks with Sabouraud dextrose broth for the liquid phase of the biphasic culture, also known as preculture...
September 26, 2017: Revista Argentina de Microbiología
https://www.readbyqxmd.com/read/28966254/genotoxic-evaluation-of-duloxetine-ii-the-effect-on-the-number-of-sister-chromatid-exchanges-the-mitotic-index-and-the-proliferation-kinetics-in-mouse-bone-marrow
#13
Eduardo Madrigal-Bujaidar, Isela Álvarez-González, Eduardo Osiris Madrigal-Santillán, José A Morales-González, Andrea Torres-Gómez, José Melesio Cristóbal-Luna
Duloxetine is an antidepressant which has showed valuable results, particularly in patients with major depression. This type of drugs is known to require genotoxic studies as part of their preclinical safety evaluation. In the case of duloxetine, however, there have been controversial results. Therefore, we considered it worthwhile to extend studies on the matter in an attempt to reach a conclusion. The present assay was made in mouse bone marrow to evaluate the capacity of the drug to induce sister chromatid exchanges (SCE), as well as to modify the proliferation kinetics and the mitotic index...
2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28808375/chemopreventive-and-antioxidant-effect-of-polyphenol-free-spirulina-maxima-and-its-hydrolyzed-protein-content-investigation-on-azoxymethane-treated-mice
#14
Nikte Y Martínez-Palma, Gloria Dávila-Ortiz, Cristian Jiménez-Martínez, Eduardo Madrigal-Bujaidar, Isela Álvarez-González
BACKGROUND: Spirulina maxima (Sm) is known to have nutritive value as well as a number of potentially useful biomedical properties. OBJECTIVES: The initial purpose of this report was to evaluate the inhibitory effect of the alga (without its polyphenol content), on the induction of azoxymethane (AOM)-induced colon aberrant crypts (AC) in mouse. Besides, we hydrolyzed the protein content of such mixture. Our second aim was to determine the inhibitory potential of this last plant mixture on the AOM-induced colon AC in mouse...
July 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28801770/nutrient-composition-of-culture-media-induces-different-patterns-of-co2-fixation-from-biogas-and-biomass-production-by-the-microalga-scenedesmus-obliquus-u169
#15
Francisco J Choix, Elena Polster, Rosa Isela Corona-González, Raúl Snell-Castro, Hugo O Méndez-Acosta
Microalgae are considered as a promising biotechnological strategy to capture CO2 from biogas, producing biomass with valuable energetic compounds. This study has evaluated the biotechnological potential to fix CO2 from biogas and biomass production by Scenedesmus obliquus cultured in four different formulations of culture media, C30, Bristol, Bold 3N, and C30+M, as well as the effect of methane (CH4) of biogas during CO2 fixation and biomass production. The results obtained showed that different nutrient composition and concentration of culture media, mainly micronutrient and vitamin concentrations, induced different patterns of CO2 fixation from biogas and biomass production in S...
December 2017: Bioprocess and Biosystems Engineering
https://www.readbyqxmd.com/read/28772337/microalgae-community-shifts-during-the-biogas-upgrading-in-an-alkaline-open-photobioreactor
#16
C I Granada-Moreno, A Aburto-Medina, D de Los Cobos Vasconcelos, A González-Sánchez
AIMS: To achieve the functional specialization of a microalgae community through operational tuning of an open photobioreactor used for biogas upgrading under alkaline conditions. METHODS AND RESULTS: An open photobioreactor was inoculated with an indigenous microalgae sample from the Texcoco Soda Lake. A microalgae community was adapted to fix CO2 from synthetic biogas through different culture conditions reaching a maximum of 220 mg CO2  l(-1) per day. Picochlorum sp...
August 3, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/28756290/exploring-the-association-between-bdnf-val66met-polymorphism-and-suicidal-behavior-meta-analysis-and-systematic-review
#17
Thelma Beatriz González-Castro, Marisol Salas-Magaña, Isela Esther Juárez-Rojop, María Lilia López-Narváez, Carlos Alfonso Tovilla-Zárate, Yazmín Hernández-Díaz
Suicide is a serious worldwide health problem of critical consequences. Nowadays genetic factors are considered to be an important cause of suicide. The association between Val66Met (rs6265) polymorphism of the BDNF gene and suicide behavior has been increasingly studied. The aim of this study was to perform a meta-analysis in order to unravel the possible association between BDNF gene Val66Met polymorphism and suicide behavior. These meta-analysis and systematic review were performed using 23 articles that searched for a genetic association between Val66Met and suicide behavior, including 4532 cases and 5364 control subjects...
July 22, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28751391/complete-genome-sequences-of-eight-rhizobium-symbionts-associated-with-common-bean-phaseolus-vulgaris
#18
Rosa Isela Santamaría, Patricia Bustos, Olga María Pérez-Carrascal, Fabiola Miranda-Sánchez, Pablo Vinuesa, Irma Martínez-Flores, Soledad Juárez, Luis Lozano, Esperanza Martínez-Romero, Miguel Ángel Cevallos, David Romero, Guillermo Dávila, Ernesto Ormeño-Orrillo, Víctor González
We present here the high-quality complete genome sequences of eight strains of Rhizobium-nodulating Phaseolus vulgaris Comparative analyses showed that some of them belonged to different genomic and evolutionary lineages with common symbiotic properties. Two novel symbiotic plasmids (pSyms) with P. vulgaris specificity are reported here.
July 27, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28749738/nutraceutical-potential-of-new-alfalfa-medicago-sativa-ingredients-for-beverage-preparations
#19
Maria Guadalupe Soto-Zarazúa, Moustapha Bah, Anabela Silvia Gomes Costa, Francisca Rodrigues, Filipa Botelho Pimentel, Isela Rojas-Molina, Alejandra Rojas, Maria Beatriz Prior Pinto Oliveira
Alfalfa (Medicago sativa) has been extensively used as animal feed, due to its fiber, protein, minerals, and vitamins, being also a useful source of phenolic compounds with potential therapeutic benefits. Nevertheless, its potential use as human ingredient is scarce. The aim of this work was to assess the nutritional composition, amino acid profile, and antioxidant capacity (AOC) of freeze-dried juice (FDJ) and fibrous residual material (RM), two new alfalfa-derived products (Adps) recently launched as ingredients for beverage preparations...
October 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28734803/distribution-of-kir-genes-and-kir2ds4-gene-variants-in-two-mexican-mestizo-populations
#20
Andrea Carolina Machado-Sulbaran, José Francisco Muñoz-Valle, María Guadalupe Ramírez-Dueñas, Christian Johana Baños-Hernández, Omar Graciano-Machuca, Erandi Enif Velarde-De la Cruz, Isela Parra-Rojas, Pedro Ernesto Sánchez-Hernández
Killer immunoglobulin-like receptors (KIR) are transmembrane proteins that regulate NK and T cell subsets by recognizing HLA-I molecules as ligands. The KIR gene family consists of 16 genes, located at chromosome 19q13.4. KIR gene frequencies vary among populations. In Mexico, HLA and genetic ancestry studies show that Mestizo populations have different genetic backgrounds based on admixture with European, African, and Asian ancestry. This study aimed to evaluate the frequencies of KIR genes and genotypes in Guerrero and Jalisco, two Mexican Mestizo populations located in the south and the west of the country, respectively, and to compare these frequencies with those of other populations...
October 2017: Human Immunology
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