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https://www.readbyqxmd.com/read/28446508/enrichment-of-pik3-akt-mtor-pathway-activation-in-hepatic-metastases-from-breast-cancer
#1
Mariaelena Pierobon, Corrine Ramos, Shukmei Wong, K Alex Hodge, Jessica Aldrich, Sara A Byron, Stephen P Anthony, Nicholas J Robert, Donald W Northfelt, Mohammad Jahanzeb, Linda Vocila, Julia D Wulfkuhle, Guido Gambara, Rosa Isela Gallagher, Bryant Dunetz, Nicholas Hoke, Ting Dong, David W Craig, Massimo Cristofanilli, Brian Leyland Jones, Lance Liotta, Joyce A O'Shaughnessy, John D Carpten, Emanuel F Petricoin
Purpose: Little is known about the molecular signatures associated with specific metastatic sites in breast cancer. Using comprehensive multi-omic molecular profiling, we assessed whether alterations or activation of the PI3K-AKT-mTOR pathway is associated with specific sites of breast cancer metastasis. <p>Experimental Design: NGS-based whole exome sequencing was coupled with Reverse Phase Protein Microarray (RPPA) functional signaling network analysis to explore the PI3K-AKT-mTOR axis in 32 pretreated breast cancer metastases...
April 26, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28440983/-detection-of-cardiovascular-risk-in-healthcare-workers-on-the-basis-of-who-jnc-7-atp-iii-criteria
#2
Roma Rubí Rodríguez-Reyes, José Eduardo Navarro-Zarza, Tania Leticia Tello-Divicino, Isela Parra-Rojas, Oscar Zaragoza-García, Iris Paola Guzmán-Guzmán
BACKGROUND: Anthropometric and blood pressure measurements are significant parameters in the assessment of cardiovascular risk (CVR). The aim was to establish the distribution of clinical-anthropometric parameters in health care workers according to the criteria established by WHO/JNC 7/ATP III. METHODS: Observational, cross-sectional study in 350 workers of a general hospital. Definitions of anthropometric alterations were made considering the criteria established by WHO and the Asian ATP III, while altered blood pressure was defined by criteria JNC 7 and ATP III...
May 2017: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/28429893/significant-associations-between-c-reactive-protein-levels-body-adiposity-distribution-and-peripheral-blood-cells-in-school-age-children
#3
Aralia Berenice Salgado-Bernabé, Luz Elena Ramos-Arellanol, Iris Paola Guzmán-Guzmán, José Francisco Muñoz-Valle, Natividad Castro-Alarcón, Amalia Vences-Velázquez, Lorenzo Salga-do-Goytia, Isela Parra-Rojas
Obesity is associated with a state of chronic low-grade inflammation. Ge- nerally, there are significant correlations between body mass index and increased C-reactive protein levels. We investigated the relationship of high sensitivity C-reactive protein (hsCRP) levels with body adiposity distribution and blood cell count in obese children. A cross-sec- tional study was performed in 225 Mexican children. In the study were included 106 obese and 119 normal-weight children, aged 6-13 years old. The body composition was evaluated by BMI, body circumferences and skinfold thickness...
June 2016: Investigación Clínica
https://www.readbyqxmd.com/read/28420830/antimicrobial-and-antibiofilm-activities-of-mta-supplemented-with-bismuth-lipophilic-nanoparticles
#4
Rene Hernandez-Delgadillo, Casiano Del Angel-Mosqueda, Juan Manuel Solís-Soto, Silvia Munguia-Moreno, Nayely Pineda-Aguilar, Rosa Isela Sánchez-Nájera, Shankararaman Chellam, Claudio Cabral-Romero
The objective of this work was to determine the antimicrobial and antibiofilm properties of mineral trioxide aggregate (MTA) supplemented with bismuth lipophilic nanoparticles (BisBAL NPs). The antimicrobial activity of the composite MTA-BisBAL NPs was determined by the disk diffusion assay, while antibiofilm activity was analyzed by fluorescence microscopy. The cytotoxicity of MTA-BisBAL NPs was determined on human gingival fibroblasts by optical microscopy and crystal violet staining. MTA-BisBAL NPs inhibited the growth of Enterococcus faecalis, Escherichia coli, and Candida albicans and also detached the biofilm of fluorescent E...
April 18, 2017: Dental Materials Journal
https://www.readbyqxmd.com/read/28384984/management-of-traumatic-fibroma-in-a-patient-with-cerebral-palsy-using-810nm-diode-laser
#5
Raúl Vicente Perales-Garza, Gerardo Daniel Sierra-Garcia, Rosa Isela Sánchez Nájera, áRaúl Vicente Perales-Perez
There are several treatment options for hyperplastic gingival lesions. Among these, diode lasers have the advantages of less bleeding, which is an important characteristic in mucosal lesions, a shorter procedure time, better healing, and less complications. We present the case of a 48-year-old male patient with a history of cerebral palsy and a presumptive diagnosis of traumatic fibroma. The entire lesion was removed in one session with no complications. No recurrence was observed at 3 months follow up. This procedure can be considered a good modality especially for physically challenged patients...
February 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28370133/isobolographic-analyses-of-proglumide-celecoxib-interaction-in-rats-with-painful-diabetic-neuropathy
#6
Samuel Suarez-Mendez, Carlos A Tovilla-Zarate, Luis F Ortega-Varela, Deysi Y Bermudez-Ocaña, Jorge L Blé-Castillo, Thelma B González-Castro, Alma M Zetina-Esquivel, Juan C Diaz-Zagoya, Isela Esther Juárez-Rojop
Preclinical Research The aim of the present study was to analyze the antihyperalgesic and antiallodynic interaction between the non-selective cholecystokinin (CCK) antagonist receptor, proglumide, and the selective cyclooxygenase-2 inhibitor, celecoxib in streptozotocin (STZ)-induced diabetic rats. Hyperalgesia was evaluated in the formalin test and tactile allodynia using von Frey filaments. Isobolographic analyses were employed to define the nature of the compound interactions, using a fixed dose ratio (0...
April 3, 2017: Drug Development Research
https://www.readbyqxmd.com/read/28351294/necessity-of-internet-regulation-to-prevent-suicides-in-mexico
#7
Carlos Alfonso Tovilla-Zárate, Sherezada Pool García, Isela E Juárez-Rojop, Thelma Beatriz González-Castro, Lilia López-Narváez
No abstract text is available yet for this article.
March 1, 2017: International Journal of Social Psychiatry
https://www.readbyqxmd.com/read/28342845/genotoxic-and-cytotoxic-evaluation-of-jatropha-dioica-sess%C3%A3-ex-cerv-by-the-micronucleus-test-in-mouse-peripheral-blood
#8
Diana Isela Araujo-Espino, Ana Lourdes Zamora-Perez, Guillermo Moisés Zúñiga-González, Rosalinda Gutiérrez-Hernández, Gabriela Morales-Velazquez, Blanca Patricia Lazalde-Ramos
Jatropha dioica Sessé ex Cerv. is a medicinal plant credited with low cytotoxicity in vitro. Thus, the objective of this work was to evaluate the possible genotoxic and cytotoxic effect in vivo of the J. dioica aqueous extract by means of micronucleus assay in mouse peripheral blood. Four different J. dioica aqueous extract dose-units were evaluated (30, 60, 100, and 300 mg/kg). The extract was administered orally to male Balb-C-strain mice every 24 h during 5 days. Blood samples were taken at 0, 24, 48, 72, 96, and 120 h from the mouse's tail and were performed in duplicate extensions...
March 23, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/28302777/complete-genome-sequences-of-three-rhizobium-gallicum-symbionts-associated-with-common-bean-phaseolus-vulgaris
#9
Patricia Bustos, Rosa Isela Santamaría, Olga María Pérez-Carrascal, José Luis Acosta, Luis Lozano, Soledad Juárez, Irma Martínez-Flores, Esperanza Martínez-Romero, Miguel Ángel Cevallos, David Romero, Guillermo Dávila, Pablo Vinuesa, Fabiola Miranda, Ernesto Ormeño, Víctor González
The whole-genome sequences of three strains of Rhizobium gallicum reported here support the concept that the distinct nodulation host ranges displayed by the symbiovars gallicum and phaseoli can be largely explained by different symbiotic plasmids.
March 16, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28291534/ptpn22-1123g-c-polymorphism-and-anti-cyclic-citrullinated-protein-antibodies-in-rheumatoid-arthritis
#10
José Francisco Muñoz-Valle, Jorge Ramón Padilla-Gutiérrez, Jorge Hernández-Bello, Yeniley Ruiz-Noa, Yeminia Valle, Claudia Azucena Palafox-Sánchez, Isela Parra-Rojas, Sergio Ramón Gutiérrez-Ureña, Hector Rangel-Villalobos
BACKGROUND AND OBJECTIVES: The protein tyrosine phosphatase non-receptor type 22 (PTPN22) gene encodes an important negative regulator of T-cell activation, lymphoid-specific phosphatase -Lyp- and has been associated with different autoimmune disorders. The PTPN22 -1123G>C polymorphism appears to affect the transcriptional control of this gene, but to date, the biological significance of this polymorphisms on rheumatoid arthritis (RA) risk remains unknown. We evaluate the association of PTPN22 -1123G>C polymorphism with anti-cyclic citrullinated protein antibodies (anti-CCP) and risk for RA in population from Western Mexico...
March 10, 2017: Medicina Clínica
https://www.readbyqxmd.com/read/28262198/association-of-g308a-and-g238a-polymorphisms-of-the-tnf-%C3%AE-gene-with-risk-of-coronary-heart-disease-systematic-review-and-meta-analysis
#11
Karely Pulido-Gómez, Yazmín Hernández-Díaz, Carlos Alfonso Tovilla-Zárate, Isela Esther Juárez-Rojop, Thelma Beatriz González-Castro, María Lilia López-Narváez, Mariela Alpuin-Reyes
BACKGROUND AND AIMS: It is widely acknowledged that coronary heart disease (CHD) has a genetic influence. One of the most promising candidate genes is tumor necrosis factor-alpha (TNF-α). Although there have been several positive studies associating the TNF-α gene and CHD, the evidence is not entirely consistent. The aim of the study was to evaluate the role of the TNF-α gene in CHD using combined evidence by generating a meta-analysis and a systematic review of all published data...
October 2016: Archives of Medical Research
https://www.readbyqxmd.com/read/28260903/gender-differences-in-the-association-between-htr2c-gene-variants-and-suicidal-behavior-in-a-mexican-population-a-case-control-study
#12
Gabriel Molina-Guzman, Thelma Beatriz González-Castro, Yazmín Hernández Díaz, Carlos Alfonso Tovilla-Zárate, Isela E Juárez-Rojop, Crystell Guadalupe Guzmán-Priego, Alma Genis, Sherezada Pool García, María Lilia López-Narvaez, José Manuel Rodriguez-Perez
BACKGROUND: The aim of this case-control study was to explore the association by gender between the HTR2C gene variants and suicidal behavior in a Mexican population. SUBJECTS AND METHODS: A total of 183 suicide attempters and 208 healthy volunteers were included in this study. We genotyped five polymorphisms of HTR2C (rs547536, rs2192372, rs4272555, rs6318, and rs2428707), then measured the association by genotype, allele, and haplotype. RESULTS: In the female group, we found an association between two polymorphisms of the HTR2C (rs4272555 and rs2428707) and suicide attempts...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28244778/las-medidas-antropom%C3%A3-tricas-como-indicadores-predictivos-de-riesgo-metab%C3%A3-lico-en-una-poblaci%C3%A3-n-mexicana
#13
Teresa Domínguez-Reyes, Irma Quiroz-Vargas, Aralia Berenice Salgado-Bernabé, Lorenzo Salgado-Goytia, José Francisco Muñoz-Valle, Isela Parra-Rojas
Introducción: actualmente se considera que la acumulación de grasa corporal a nivel central se asocia con la presencia de hipertrigliceridemia, hipertensión arterial y diabetes. El índice de masa corporal (IMC) se ha utilizado para identificar la obesidad en la población general, pero no permite determinar la distribución de la grasa corporal, por lo que se pueden utilizar otras medidas antropométricas para evaluar la adiposidad y determinar su relación con la presencia de alteraciones metabólicas que presentan las personas con exceso de peso...
February 1, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/28165410/bone-mineral-density-mechanical-microstructural-properties-and-mineral-content-of-the-femur-in-growing-rats-fed-with-cactus-opuntia-ficus-indica-l-mill-cactaceae-cladodes-as-calcium-source-in-diet
#14
Ezequiel Hernández-Becerra, Elsa Gutiérrez-Cortez, Alicia Del Real, Alejandra Rojas-Molina, Mario Rodríguez-García, Efraín Rubio, Michelle Quintero-García, Isela Rojas-Molina
Mechanical, microstructural properties, mineral content and bone mineral density (BMD) of the femur were evaluated in growing rats fed with Opuntia ficus indica (L.) Mill. (Cactaceae) cladodes at different maturity stages as calcium source. Male weanling rats were fed with cladodes at early maturity stage (25 and 60 days of age, belonging to groups N-60 and N-200, respectively) and cladodes at late maturity stage (100 and 135 days of age, belonging to groups N-400 and N-600, respectively) for 6 weeks. Additionally, a control group fed with calcium carbonate as calcium source was included for comparative purposes...
February 4, 2017: Nutrients
https://www.readbyqxmd.com/read/28141710/the-curse-of-the-dolphins-cognitive-decline-and-psychosis
#15
Randall Phelps, Anne Tsai, Arlene Hagen, Joseph Pinter, Raegan Smith, Martin T Stein
Isela is an 11-year-old Mexican-American girl with mild intellectual disability. During a vacation with her family, she went swimming with dolphins. A few days later, Isela awoke at night with laughing spells; during the day, she was pacing, aggressive, and had a decline in self-care and communication skills. Her parents attributed the symptoms to the dolphins. She was evaluated by a pediatric neurologist. The sleep-deprived electroencephalogram, brain magnetic resonance imaging, lumbar puncture, and thyroid function tests were normal...
February 2017: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/28102579/anatomical-organization-and-somatic-axonal-components-of-the-lumbosacral-nerves-in-female-rabbits
#16
Yolanda Cruz, Isela Hernández-Plata, Rosa Angélica Lucio, René Zempoalteca, Francisco Castelán, Margarita Martínez-Gómez
AIM: To determine the anatomical organization and somatic axonal components of the lumbosacral nerves in female rabbits. METHODS: Chinchilla adult anesthetized female rabbits were used. Anatomical, electrophysiological, and histological studies were performed. RESULTS: L7, S1, and some fibers from S2 and S3 form the lumbosacral trunk, which gives origin to the sciatic nerve and innervation to the gluteal region. From S2 to S3 originates the pudendal nerve, whose branches innervates the striated anal and urethra sphincters, as well as the bulbospongiosus, ischiocavernosus, and constrictor vulvae muscles...
January 19, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/27977322/blue-maize-extract-improves-blood-pressure-lipid-profiles-and-adipose-tissue-in-high-sucrose-diet-induced-metabolic-syndrome-in-rats
#17
Rosa Isela Guzmán-Gerónimo, Tania Margarita Alarcón-Zavaleta, Rosa María Oliart-Ros, José Enrique Meza-Alvarado, Socorro Herrera-Meza, José Luis Chávez-Servia
The effect of blue maize extract in factors related to metabolic syndrome (MS) in Wistar rats was investigated. Total polyphenols, monomeric anthocyanins, and antioxidant activity were analyzed in blue maize. MS was induced in Wistar rats fed with high-sucrose (HS) diet for 12 weeks. During a period of 4 weeks, blue maize extract was administrated to HS groups fed with high-sucrose and high-cholesterol-high-sucrose (HS+C) diets. In the blue maize extract administered by orogastric cannulation, the levels of total polyphenols and anthocyanins were 9...
February 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/27858903/effects-of-paraoxonase-1-gene-polymorphisms-on-heart-diseases-systematic-review-and-meta-analysis-of-64-case-control-studies
#18
REVIEW
Yazmín Hernández-Díaz, Carlos Alfonso Tovilla-Zárate, Isela Esther Juárez-Rojop, Thelma Beatriz González-Castro, Candelario Rodríguez-Pérez, María Lilia López-Narváez, José Manuel Rodríguez-Pérez, José Francisco Cámara-Álvarez
BACKGROUND: Associations between paraoxonase 1 (PON1) gene polymorphisms and heart diseases (HD) risk remain inconsistent. In order to obtain address this issue we performed a meta-analysis to assess the association between the L55M and Q192R polymorphisms of PON1 gene and heart diseases risk. METHODS: Relevant studies were enrolled by searching databases systematically. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to calculate the strength of association...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27855929/physicochemical-properties-of-nixtamalized-corn-flours-with-and-without-germ
#19
Lineth J Vega Rojas, Isela Rojas Molina, Elsa Gutiérrez Cortez, Natalia Rincón Londoño, Andrés A Acosta Osorio, Alicia Del Real López, Mario E Rodríguez García
This research studied the influence of the germ components on the physicochemical properties of cooked corn and nixtamalized corn flours as a function of the calcium hydroxide content (from 0 to 2.1 w/w) and steeping time (between 0 and 9h). A linear relationship was found between calcium content in germ and steeping time used during nixtamalization process. X-ray diffraction analysis showed that calcium carbonate is formed into the germ structure to 2.1 w/w of calcium hydroxide and 9h steeping time. The presence of the germ improves the development of peak viscosity in flours, and it is related to the increases in calcium concentration in germ and the formation of amylose-lipid complexes...
April 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27829443/the-role-of-c957t-taqi-and-ser311cys-polymorphisms-of-the-drd2-gene-in-schizophrenia-systematic-review-and-meta-analysis
#20
REVIEW
Thelma Beatriz González-Castro, Yazmín Hernández-Díaz, Isela Esther Juárez-Rojop, María Lilia López-Narváez, Carlos Alfonso Tovilla-Zárate, Alma Genis-Mendoza, Mariela Alpuin-Reyes
BACKGROUND: The association between the dopamine D2 receptor (DRD2) gene and schizophrenia has been studied though no conclusive outcomes have been attained. The aim of this study was to perform a systematic review and meta-analysis to explore the relation between three polymorphisms of the DRD2 gene (C957T, TaqI and Ser311Cys) and schizophrenia. METHODS: The search was made in PubMed and EBSCO databases (up to February 2016). The systematic review included 34 case-control association studies (34 for C957T, 16 for TaqI and 36 for Ser311Cys)...
November 9, 2016: Behavioral and Brain Functions: BBF
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