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https://www.readbyqxmd.com/read/29765284/influence-of-serum-leptin-levels-and-q223r-leptin-receptor-polymorphism-on-clinical-characteristic-of-patients-with-rheumatoid-arthritis-from-western-mexico
#1
Luis I Angel-Chávez, Elizabeth Ruelas-Cinco, Jorge Hernández-Bello, Elena Castro, Mirna Vázquez-Villamar, Isela Parra-Rojas, L Michele Brennan-Bourdon, Salvador Muñoz-Barrios, Celia Guerrero-Velázquez, José Francisco Muñoz-Valle
Objective: The aim of the present study was to evaluate the possible association between the Q223R Leptin receptor (LEPR) polymorphism (A>G; rs1137101) and leptin levels in patients with rheumatoid arthritis (RA) from Western Mexico. Methods: A cross-sectional study was performed with 70 RA patients and 74 controls subject (CS). Disease activity was evaluated using DAS28 score, the Q223R LEPR polymorphism was determined by the Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) and serum leptin levels, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) and rheumatoid factor (RF) were quantified...
April 2018: EJIFCC
https://www.readbyqxmd.com/read/29746748/-evolution-of-food-insecurity-in-mexican-households-2012-2016
#2
Verónica Mundo-Rosas, Norma Isela Vizuet-Vega, Jesús Martínez-Domínguez, M Del Carmen Morales-Ruán, Rafael Pérez-Escamilla, Teresa Shamah-Levy
OBJECTIVE: To describe three relevant aspects of household food insecurity (FI) in Mexico: its magnitude, its distribution by social and nutritional vulnerability characteristics; its evolution between 2012 and 2016 and the effect of food assistance programs on FI in Mexican households. MATERIALS AND METHODS: Data on 9 019 households were drawn from the 2016 National Health and Nutrition Survey (Ensanut 2016 for its Spanish initials) and were compared with data from the 2012 Ensanut...
May 2018: Salud Pública de México
https://www.readbyqxmd.com/read/29723946/-plantago-psyllium-secondary-anaphylaxis-case-report
#3
Rodrigo Collado-Chagoya, Javier Hernández-Romero, Gumaro Alejandro Eliosa-Alvarado, Ana Carmen García-González, Rosa Isela Campos-Gutiérrez, Andrea Velasco-Medina, Guillermo Velázquez-Sámano
BACKGROUND: Psyllium is a derivative of Plantago ovata ground seed and husk that is used as bulk-forming laxatives owing to its hydrocolloid properties. CASE REPORT: 43-year-old female nurse with previous diagnosis of drug allergy and allergic rhinitis who, after the preparation and administration of a laxative, developed rhinoconjunctivitis symptoms, urticarial syndrome, angioedema and bronchospasm, which led to conclude that she had an anaphylactic reaction. She was treated with adrenaline, corticosteroids and antihistamines...
January 2018: Revista Alergia Mexico: Organo Oficial de la Sociedad Mexicana de Alergia e Inmunología, A.C
https://www.readbyqxmd.com/read/29720568/pdcs-in-lung-and-skin-fibrosis-in-a-bleomycin-induced-model-and-patients-with-systemic-sclerosis
#4
Suzanne Kafaja, Isela Valera, Anagha A Divekar, Rajan Saggar, Fereidoun Abtin, Daniel E Furst, Dinesh Khanna, Ram Raj Singh
Fibrosis is the end result of most inflammatory conditions, but its pathogenesis remains unclear. We demonstrate that, in animals and humans with systemic fibrosis, plasmacytoid DCs (pDCs) are unaffected or are reduced systemically (spleen/peripheral blood), but they increase in the affected organs (lungs/skin/bronchoalveolar lavage). A pivotal role of pDCs was shown by depleting them in vivo, which ameliorated skin and/or lung fibrosis, reduced immune cell infiltration in the affected organs but not in spleen, and reduced the expression of genes and proteins implicated in chemotaxis, inflammation, and fibrosis in the affected organs of animals with bleomycin-induced fibrosis...
May 3, 2018: JCI Insight
https://www.readbyqxmd.com/read/29694633/a-possible-association-between-the-2518-a-g-mcp-1-polymorphism-and-insulin-resistance-in-school-children
#5
Inés Matia-García, Lorenzo Salgado-Goytia, Luz Elena Ramos-Arellano, José Francisco Muñoz-Valle, Adakatia Armenta-Solís, Olga Lilia Garibay-Cerdenares, Mónica Ramírez, Isela Parra-Rojas
Objective Monocyte chemoattractant protein 1 (MCP-1) has been suggested to be involved in the pathophysiology of insulin resistance (IR); therefore, variants in the MCP-1 gene may contribute to the development of this disease. The aim of this study was to analyze the relationship of the -2518 A>G MCP-1 (rs1024611) gene polymorphism with insulin resistance in Mexican children. Subjects and methods A cross-sectional study was performed in 174 children, including 117 children without insulin resistance and 57 children with IR, with an age range of 6-11 years...
February 2018: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29673971/changes-in-trophoblasts-gene-expression-in-response-to-perchlorate-exposition
#6
De la Peña Sol, Santiago-Roque Isela, Olivo-Vidal Zendy, Navarro-Meza Mónica, Xochihua-Rosas Irene, Arroyo-Helguera Omar
Contaminated water with chlorates is a public health problem associated with iodine deficiency. Epidemiological evidence shows that iodine deficiency is a risk factor for preeclampsia (PE). In this study we use human BeWo trophoblast cells exposed to perchlorate (KClO4 ) and changes in gene expression were analyzed by microarrays, quantitative RT-PCR (qRT-PCR) and immunoblot. The microarray analysis identified 48 transcripts up-regulated and 112 down-regulated in comparison with non-exposed trophoblast. The qRT-PCR analysis confirmed changes in GAS7, PKP2, Emilin, Dynatic 3, protocadherins 11, 15, gamma A12, EGFR, SAFB1, ACE2, ANXA2, Apoliprotein E, SREBF1, and C/EBP-β...
April 16, 2018: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/29594736/gold-nanorods-for-in-drop-colorimetric-determination-of-thiomersal-after-photochemical-decomposition
#7
Manuel Martín-Alonso, Francisco Pena-Pereira, Isela Lavilla, Carlos Bendicho
This work reports on the implementation of gold nanorods (AuNRs) in headspace solvent microextraction for colorimetric determination of volatile analyte derivatives in a single drop. The exposure of AuNRs to both H2 Se and elemental mercury (Hg0 ) results in a shift of the longitudinal plasmonic band, unlike a number of volatiles. Accordingly, a method is reported for the determination of Hg0 with potential applicability to the determination of thiomersal (sodium ethylmercurithiosalicylate). It is based on the photochemical decomposition of thiomersal into Hg(II) and subsequent exposure of AuNRs-containing microdrop to in situ generated Hg0 ...
March 13, 2018: Mikrochimica Acta
https://www.readbyqxmd.com/read/29527265/morphological-and-biochemical-effects-of-weekend-alcohol-consumption-in-rats-role-of-concentration-and-gender
#8
José A Morales-González, María de Lourdes Sernas-Morales, Ángel Morales-González, Laura Ligía González-López, Eduardo Osiris Madrigal-Santillán, Nancy Vargas-Mendoza, Tomás Alejandro Fregoso-Aguilar, Liliana Anguiano-Robledo, Eduardo Madrigal-Bujaidar, Isela Álvarez-González, Germán Chamorro-Cevallos
AIM: To examine the association between weekend alcohol consumption and the biochemical and histological alterations at two different concentrations of alcohol in both genders in rats. METHODS: Wistar rats weighing 170-200 g were divided into groups as follows: (1) Control groups; and (2) weekend alcohol-consumption group: 2 d/weekly per 12 wk, at two different concentrations: (1) Group of males or females with a consumption of a solution of alcohol at 40%; and (2) group of males or females with a consumption of a solution of alcohol at 5%...
February 27, 2018: World Journal of Hepatology
https://www.readbyqxmd.com/read/29475479/test-for-arsenic-speciation-in-waters-based-on-a-paper-based-analytical-device-with-scanometric-detection
#9
Francisco Pena-Pereira, Lorena Villar-Blanco, Isela Lavilla, Carlos Bendicho
A rapid, simple and affordable method for arsenic speciation analysis is described in this work. The proposed methodology involves in situ arsine generation, transfer of the volatile to the headspace and its reaction with silver nitrate at the detection zone of a paper-based analytical device (PAD). Thus, silver nitrate acts as a recognition element for arsine in the paper-based sensor. The chemical reaction between the recognition element and the analyte derivative results in the formation of a colored product which can be detected by scanning the detection zone and data treatment with an image processing and analysis program...
June 29, 2018: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29441810/pon2-and-pparg-polymorphisms-as-biomarkers-of-risk-for-coronary-heart-disease
#10
Thelma Beatriz González-Castro, Carlos Alfonso Tovilla-Zárate, Isela Esther Juárez-Rojop, Yazmín Hernández-Díaz, María Lilia López-Narváez, Candelario Rodríguez-Pérez, Yahaira Karina González-Hernández, Miguel Ángel Ramos-Méndez
AIM: Investigate the correlation between paraoxonase 2 (PON2) Ser311Cys polymorphism as well as the peroxisome proliferator-activated receptor gamma (PPARG) His477His polymorphism and the susceptibility to development of coronary heart diseases (CHD) through a meta-analysis. METHODS: Odds ratio and the corresponding 95% CI were used to assess the results. We included 7476 CHD patients and 8504 healthy controls. All the statistical analyses were performed by Comprehensive Meta-Analysis software (CMA, version 2...
March 2018: Biomarkers in Medicine
https://www.readbyqxmd.com/read/29397904/mif-promotes-a-differential-th1-th2-th17-inflammatory-response-in-human-primary-cell-cultures-predominance-of-th17-cytokine-profile-in-pbmc-from-healthy-subjects-and-increase-of-il-6-and-tnf-%C3%AE-in-pbmc-from-active-sle-patients
#11
Ulises De la Cruz-Mosso, Trinidad García-Iglesias, Richard Bucala, Iris Estrada-García, Laura González-López, Sergio Cerpa-Cruz, Isela Parra-Rojas, Jorge Iván Gámez-Nava, Edsaúl Emilio Pérez-Guerrero, José Francisco Muñoz-Valle
Macrophage migration Inhibitory Factor (MIF) is a cytokine associated with the pathogenesis of autoimmune inflammatory diseases. There is evidence that MIF functions in a positive-feedback-loop with proinflammatory cytokines and could perpetuate the inflammatory process in Systemic Lupus Erythematosus (SLE).The aim of this study was to assess the effect of recombinant-human-MIF (rhMIF) on the expression of Th1, Th2 and Th17 cytokines in Peripheral Blood Mononuclear Cells (PBMC) from Healthy Subjects (HS) and SLE patients...
February 2018: Cellular Immunology
https://www.readbyqxmd.com/read/29284137/grapefruit-and-its-biomedical-antigenotoxic-and-chemopreventive-properties
#12
REVIEW
José Melesio Cristóbal-Luna, Isela Álvarez-González, Eduardo Madrigal-Bujaidar, Germán Chamorro-Cevallos
Grapefruit (Citrus paradisi Mcfad) is a perenifolium tree 5-6 m high with a fruit of about 15 cm in diameter, protected by the peel we can find about 11-14 segments (carpels), each of which is surrounded by a membrane and each containing the juice sacs, as well as the seeds. The fruit is made up of numerous compounds, and is known to have nutritive value because of the presence of various vitamins and minerals, among other chemicals. The fruit is also used in the field of gastronomy. Information has been accumulated regarding the participation of the fruit structures in a variety of biomedical, antigenotoxic and chemopreventive effects, surely related with the presence of the numerous chemicals that have been determined to constitute the fruit...
February 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29235025/effects-of-exposure-to-malathion-on-blood-glucose-concentration-a-meta-analysis
#13
Marco Antonio Ramirez-Vargas, Eugenia Flores-Alfaro, Mayrut Uriostegui-Acosta, Patricia Alvarez-Fitz, Isela Parra-Rojas, Ma Elena Moreno-Godinez
Exposure to malathion (an organophosphate pesticide widely used around the world) has been associated with alterations in blood glucose concentration in animal models. However, the results are inconsistent. The aim of this meta-analysis was to evaluate whether malathion exposure can disturb the concentrations of blood glucose in exposed rats. We performed a literature search of online databases including PubMed, EBSCO, and Google Scholar and reviewed original articles that analyzed the relation between malathion exposure and glucose levels in animal models...
February 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29202842/preclinical-and-clinical-aspects-of-tnf-%C3%AE-and-its-receptors-tnfr1-and-tnfr2-in-breast-cancer
#14
REVIEW
Isela Martínez-Reza, Lorenza Díaz, Rocío García-Becerra
Breast cancer is the most common malignancy in women and a public health problem worldwide. Breast cancer is often accompanied by an inflammatory process characterized by the presence of proinflammatory cytokines such as tumor necrosis factor (TNF-α), which has important implications in the course of the disease. Inflammation has been described primarily as a favorable environment for tumor development. However, under certain conditions TNF-α can promote signals for activation, differentiation, survival or cell death, so the study of the variants of this cytokine, its receptors, the presence of polymorphisms and its implication in different phenotypes of breast cancer is necessary...
December 4, 2017: Journal of Biomedical Science
https://www.readbyqxmd.com/read/29187287/association-between-leptin-and-disease-activity-in-patients-with-rheumatoid-arthritis
#15
José Antonio de Jesús Batún-Garrido, Marisol Salas-Magaña, Isela Esther Juárez-Rojop, Eúfrates Hernández-Núñez, Francisco Olán
BACKGROUND AND OBJECTIVE: Multiple studies have found a direct relationship between leptin concentrations and disease activity in rheumatoid arthritis. PATIENTS AND METHODS: We studied 77 patients with the diagnosis of rheumatoid arthritis; the leptin determination was through an enzyme immunoassay. Disease activity was assessed by the DAS-28 CRP. A multivariate logistic regression model was used to determine the association between significant variables and leptin concentrations...
November 26, 2017: Medicina Clínica
https://www.readbyqxmd.com/read/29101672/association-between-leptin-and-il-6-concentrations-with-cardiovascular-risk-in-patients-with-rheumatoid-arthritis
#16
José Antonio De Jesús Batún-Garrido, Marisol Salas-Magaña, Isela Esther Juárez-Rojop
Pro-inflammatory cytokines such as leptin and IL-6 play an important role in the development of cardiovascular risk. Determine the relationship between leptin and IL-6 concentrations with cardiovascular risk in patients with rheumatoid arthritis. We determined IL-6 and leptin levels in 77 patients with the diagnosis of rheumatoid arthritis. The cardiovascular risk was calculated using the modified Framingham scale. Statistical analysis was performed using SPSS 22 considering a significant p < 0.05. Serum leptin concentrations and cardiovascular risk (CVR) factors were compared and found that there was a significant difference between higher leptin values and disease activity (p 0...
March 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29090355/microbiological-comparison-of-blood-culture-and-amplification-of-16s-rdna-methods-in-combination-with-dgge-for-detection-of-neonatal-sepsis-in-blood-samples
#17
Isela García-Gudiño, Eucario Yllescas-Medrano, Rolando Maida-Claros, Diana Soriano-Becerril, Nestor F Díaz, Guadalupe García-López, Anayansí Molina-Hernández, Oscar Flores-Herrera, Francisco J Zavala-Díaz de la Serna, María Del Rosario Peralta-Pérez, Héctor Flores-Herrera
It is estimated that 15% of all newborns admitted to the neonatal intensive care unit (NICU) for suspected sepsis receive multiple broad-spectrum antibiotics without pathogen identification. The gold standard for bacterial sepsis detection is blood culture, but the sensitivity of this method is very low. Recently, amplification and analysis of the 16S ribosomal DNA (rDNA) bacterial gene in combination with denaturing gradient gel electrophoresis (DGGE) has proven to be a useful approach for identifying bacteria that are difficult to isolate by standard culture methods...
January 2018: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29049139/the-role-of-the-cys23ser-rs6318-polymorphism-of-the-htr2c-gene-in-suicidal-behavior-systematic-review-and-meta-analysis
#18
REVIEW
Thelma B González-Castro, Yazmín Hernandez-Diaz, Isela E Juárez-Rojop, Lilia López-Narváez, Carlos A Tovilla-Zárate, José M Rodriguez-Perez, Juan P Sánchez-de la Cruz
The polymorphisms of the serotonin receptor 2C (HTR2C) gene have been proposed to influence suicidal behavior. The aim of our study was to explore the role of the HTR2C gene variant Cys23Ser (rs6318) in the pathogenesis of suicidal behavior through a systematic review and meta-analysis. The search was performed using EBSCO and PubMed databases. To be included in the analysis, the studies had to evaluate suicidal behavior (attempted, ideation, or completed suicide). The results of the meta-analysis were expressed as odds ratios (ORs)...
December 2017: Psychiatric Genetics
https://www.readbyqxmd.com/read/29035935/prevalence-and-correlations-between-suicide-attempt-depression-substance-use-and-functionality-among-patients-with-limb-amputations
#19
Pedro I Arias Vázquez, Rosa G Castillo Avila, Mayra Del C Dominguez Zentella, Yazmín Hernández-Díaz, Thelma B González-Castro, Carlos A Tovilla-Zárate, Isela E Juárez-Rojop, María L López-Narváez, Ana Frésan
Most patients undergoing limb amputations suffer significant emotional changes. The aim of this study was to estimate the prevalence of suicide attempts and depression in a sample of Mexican patients with limb amputations and, second, to determine whether the patients' functionality correlates with the presence of depression. We studied 40 patients who had undergone a limb amputation. The suicide attempt was evaluated using the Suicide Intent Scale. The depression was assessed using the Hamilton Depression Rating Scale, whereas the functionality of the patients was measured using the Functional Independence Measure...
March 2018: International Journal of Rehabilitation Research. Revue Internationale de Recherches de Réadaptation
https://www.readbyqxmd.com/read/29035840/characteristics-of-mexican-children-and-adolescents-who-died-by-suicide-a-study-of-psychological-autopsies
#20
Thelma Beatriz González-Castro, Carlos Alfonso Tovilla-Zárate, Yazmín Hernández-Díaz, Isela E Juárez-Rojop, Alejandra Giovanna León-Garibay, Crystell Guadalupe Guzmán-Priego, Lilia López-Narváez, Ana Frésan
OBJECTIVE: In recent years, suicide in children and adolescents has increased considerably, becoming the second cause of death in this age group. Therefore, the aim of this study was to identify characteristics and factors that could precipitate deaths by suicide in children and adolescents. METHODS: Using the psychological autopsy method, we studied 28 suicide cases of children and adolescents between 10 and 17 years old. Socio-demographic factors, characteristics of the suicide and family history were documented...
November 2017: Journal of Forensic and Legal Medicine
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