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https://www.readbyqxmd.com/read/28107365/parenclitic-network-analysis-of-methylation-data-for-cancer-identification
#1
Alexander Karsakov, Thomas Bartlett, Artem Ryblov, Iosif Meyerov, Mikhail Ivanchenko, Alexey Zaikin
We make use of ideas from the theory of complex networks to implement a machine learning classification of human DNA methylation data, that carry signatures of cancer development. The data were obtained from patients with various kinds of cancers and represented as parenclictic networks, wherein nodes correspond to genes, and edges are weighted according to pairwise variation from control group subjects. We demonstrate that for the 10 types of cancer under study, it is possible to obtain a high performance of binary classification between cancer-positive and negative samples based on network measures...
2017: PloS One
https://www.readbyqxmd.com/read/28107204/non-invasive-blood-glucose-detection-system-based-on-conservation-of-energy-method
#2
Yang Zhang, Jian-Ming Zhu, Yong-Bo Liang, Hong-Bo Chen, Shi-Min Yin, Zhen-Cheng Chen
The most common method used for minimizing the occurrence of diabetes complications is frequent glucose testing to adjust the insulin dose. However, using blood glucose (BG) meters presents a risk of infection. It is of great importance to develop non-invasive BG detection techniques. To realize high-accuracy, low-cost and continuous glucose monitoring, we have developed a non-invasive BG detection system using a mixed signal processor 430 (MSP430) microcontroller. This method is based on the combination of the conservation-of-energy method with a sensor integration module, which collects physiological parameters, such as the blood oxygen saturation (SPO2), blood flow velocity and heart rate...
January 20, 2017: Physiological Measurement
https://www.readbyqxmd.com/read/28107039/future-directions-in-the-study-of-early-life-stress-and-physical-and-emotional-health-implications-of-the-neuroimmune-network-hypothesis
#3
Camelia E Hostinar, Robin Nusslock, Gregory E Miller
Early-life stress is associated with increased vulnerability to physical and emotional health problems across the lifespan. The recently developed neuroimmune network hypothesis proposes that one of the underlying mechanisms for these associations is that early-life stress amplifies bidirectional crosstalk between the brain and the immune system, contributing to several mental and physical health conditions that have inflammatory underpinnings, such as depression and coronary heart disease. Neuroimmune crosstalk is thought to perpetuate inflammation and neural alterations linked to early-life stress exposure, and also foster behaviors that can further compromise health, such as smoking, drug abuse and consumption of high-fat diets...
January 20, 2017: Journal of Clinical Child and Adolescent Psychology
https://www.readbyqxmd.com/read/28106086/efficient-method-for-comprehensive-computation-of-agent-level-epidemic-dissemination-in-networks
#4
Gilberto M Nakamura, Ana Carolina P Monteiro, George C Cardoso, Alexandre S Martinez
Susceptible-infected (SI) and susceptible-infected-susceptible (SIS) are simple agent-based models often employed in epidemic studies. Both models describe the time evolution of infectious diseases in networks whose vertices are either susceptible (S) or infected (I) agents. Precise estimation for disease spreading is one of the major goals in epidemic studies but often restricted to heavy numerical simulations. Analytic methods using operatorial content are subject to the asymmetric eigenvalue problem, limiting the use of perturbative methods...
January 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28104462/questionnaires-used-to-assess-barriers-of-clinical-guideline-use-among-physicians-are-not-comprehensive-reliable-or-valid-a-scoping-review
#5
REVIEW
Melina L Willson, Robin Wm Vernooij, Anna R Gagliardi
OBJECTIVE: This study described the number and characteristics of questionnaires used to assess barriers of guideline use among physicians. STUDY DESIGN: A scoping review was conducted. MEDLINE and EMBASE were searched from 2005 to June 2016. English language studies that administered a questionnaire to assess barriers of guideline use among practicing physicians were eligible. Summary statistics were used to report study and questionnaire characteristics. Questionnaire content was assessed with a checklist of 57 known barriers...
January 16, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/28104411/brain-and-cognitive-reserve-translation-via-network-control-theory
#6
REVIEW
John Dominic Medaglia, Fabio Pasqualetti, Roy H Hamilton, Sharon L Thompson-Schill, Danielle S Bassett
Traditional approaches to understanding the brain's resilience to neuropathology have identified neurophysiological variables, often described as brain or cognitive "reserve," associated with better outcomes. However, mechanisms of function and resilience in large-scale brain networks remain poorly understood. Dynamic network theory may provide a basis for substantive advances in understanding functional resilience in the human brain. In this perspective, we describe recent theoretical approaches from network control theory as a framework for investigating network level mechanisms underlying cognitive function and the dynamics of neuroplasticity in the human brain...
January 16, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28103925/protocol-for-a-realist-review-of-workplace-learning-in-postgraduate-medical-education-and-training
#7
Anel Wiese, Caroline Kilty, Colm Bergin, Patrick Flood, Na Fu, Mary Horgan, Agnes Higgins, Bridget Maher, Grainne O'Kane, Lucia Prihodova, Dubhfeasa Slattery, Deirdre Bennett
BACKGROUND: Postgraduate medical education and training (PGMET) is a complex social process which happens predominantly during the delivery of patient care. The clinical learning environment (CLE), the context for PGMET, shapes the development of the doctors who learn and work within it, ultimately impacting the quality and safety of patient care. Clinical workplaces are complex, dynamic systems in which learning emerges from non-linear interactions within a network of related factors and activities...
January 19, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28103476/on-the-globality-of-motor-suppression-unexpected-events-and-their-influence-on-behavior-and-cognition
#8
REVIEW
Jan R Wessel, Adam R Aron
Unexpected events are part of everyday experience. They come in several varieties-action errors, unexpected action outcomes, and unexpected perceptual events-and they lead to motor slowing and cognitive distraction. While different varieties of unexpected events have been studied largely independently, and many different mechanisms are thought to explain their effects on action and cognition, we suggest a unifying theory. We propose that unexpected events recruit a fronto-basal-ganglia network for stopping...
January 18, 2017: Neuron
https://www.readbyqxmd.com/read/28103287/does-a-species-extinction-proneness-predict-its-contribution-to-nestedness-a-test-using-a-sunbird-tree-visitation-network
#9
Charles A Nsor, Hazel M Chapman, William Godsoe
Animal pollinators and the plants they pollinate depend on networks of mutualistic partnerships and more broadly on the stability of such networks. Based mainly on insect-plant visitation networks, theory predicts that species that are most prone to extinction contribute the most to nestedness, however empirical tests are rare. We used a sunbird-tree visitation network within which were both extinction prone vs non extinction prone sunbird species to test the idea. We predicted that the extinction prone species would contribute the most to nestedness...
2017: PloS One
https://www.readbyqxmd.com/read/28102689/high-dimensional-atomistic-neural-network-potentials-for-molecule-surface-interactions-hcl-scattering-from-au-111
#10
Brian Kolb, Xuan Luo, Xueyao Zhou, Bin Jiang, Hua Guo
Ab initio molecular dynamics (AIMD) simulations of molecule-surface scattering allow first-principles characterization of the dynamics. However, the large number of density functional theory calculations along the trajectories are very costly, limiting simulations of long-time events. To avoid this computational bottleneck, we report here the development of a high-dimensional molecule-surface interaction potential energy surface (PES) with movable surface atoms, using a machine learning approach. With 60 degrees of freedom, this PES allows energy transfer between the impinging molecule and surface atoms...
January 19, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28101878/bootstrapping-disaster-the-challenge-of-growing-and-maintaining-a-cross-sector-collaborative-network
#11
Aaron Wachhaus
This article examines the interaction of nonprofit and private actors with the traditional bureaucratic structures of government in central Pennsylvania&s recovery from hurricane Irene and tropical storm Lee. That effort relied heavily on private and nonprofit organizations as drivers of the response and recovery. The author maps the organizations involved in the recovery effort and explores the impact of the recovery effort on those organizations. A social network analysis was conducted and complemented with follow-up interviews with key actors...
November 2016: Journal of Emergency Management: JEM
https://www.readbyqxmd.com/read/28101746/music-preferences-friendship-and-externalizing-behavior-in-early-adolescence-a-siena-examination-of-the-music-marker-theory-using-the-snare-study
#12
Aart Franken, Loes Keijsers, Jan Kornelis Dijkstra, Tom Ter Bogt
Music Marker Theory posits that music is relevant for the structuring of peer groups and that rock, urban, or dance music preferences relate to externalizing behavior. The present study tested these hypotheses, by investigating the role of music preference similarity in friendship selection and the development of externalizing behavior, while taking the effects of friends' externalizing behavior into account. Data were used from the first three waves of the SNARE (Social Network Analysis of Risk behavior in Early adolescence) study (N = 1144; 50% boys; M age = 12...
January 18, 2017: Journal of Youth and Adolescence
https://www.readbyqxmd.com/read/28100829/a-mathematical-model-of-tumour-angiogenesis-growth-regression-and-regrowth
#13
Guillermo Vilanova, Ignasi Colominas, Hector Gomez
Cancerous tumours have the ability to recruit new blood vessels through a process called angiogenesis. By stimulating vascular growth, tumours get connected to the circulatory system, receive nutrients and open a way to colonize distant organs. Tumour-induced vascular networks become unstable in the absence of tumour angiogenic factors (TAFs). They may undergo alternating stages of growth, regression and regrowth. Following a phase-field methodology, we propose a model of tumour angiogenesis that reproduces the aforementioned features and highlights the importance of vascular regression and regrowth...
January 2017: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/28100741/control-of-spike-transfer-at-hippocampal-mossy-fiber-synapses-in-vivo-by-gabaa-and-gabab-receptor-mediated-inhibition
#14
Stefano Zucca, Marilena Griguoli, Meryl Malézieux, Noëlle Grosjean, Mario Carta, Christophe Mulle
: Despite extensive studies in hippocampal slices and incentive from computational theories, the synaptic mechanisms underlying information transfer at mossy fiber (mf) connections between the dentate gyrus (DG) and CA3 neurons in vivo are still elusive. Here we used an optogenetic approach in mice to selectively target and control the activity of DG granule cells (GCs) while performing whole-cell and juxtacellular recordings of CA3 neurons in vivo In CA3 pyramidal cells (PCs), mf-CA3 synaptic responses consisted predominantly of an IPSP at low stimulation frequency (0...
January 18, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28100734/does-the-superior-colliculus-control-perceptual-sensitivity-or-choice-bias-during-attention-evidence-from-a-multialternative-decision-framework
#15
Devarajan Sridharan, Nicholas A Steinmetz, Tirin Moore, Eric I Knudsen
: Distinct networks in the forebrain and the midbrain coordinate to control spatial attention. The critical involvement of the superior colliculus (SC)-the central structure in the midbrain network-in visuospatial attention has been shown by four seminal, published studies in monkeys (Macaca mulatta) performing multialternative tasks. However, due to the lack of a mechanistic framework for interpreting behavioral data in such tasks, the nature of the SC's contribution to attention remains unclear...
January 18, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28100728/direct-cortical-stimulation-of-human-posteromedial-cortex
#16
Brett L Foster, Josef Parvizi
BACKGROUND: The posteromedial cortex (PMC) is a collective term for an anatomically heterogeneous area of the brain constituting a core node of the human default mode network (DMN), which is engaged during internally focused subjective cognition such as autobiographical memory. METHODS: We explored the effects of causal perturbations of PMC with direct electric brain stimulation (EBS) during presurgical epilepsy monitoring with intracranial EEG electrodes. RESULTS: Data were collected from 885 stimulations in 25 patients implanted with intracranial electrodes across the PMC...
January 18, 2017: Neurology
https://www.readbyqxmd.com/read/28099019/combined-molecular-dynamics-atoms-in-molecules-and-ir-studies-of-the-bulk-mono-fluoro-ethanol-and-bulk-ethanol-to-understand-the-role-of-organic-fluorine-in-hydrogen-bond-network
#17
Biswajit Biswas, Saptarsi Mondal, Prashant Chandra Singh
Presence of the fluorocarbon group in fluorinated alcohols makes them an important class of molecules which have diverse applications in the field of separation techniques, synthetic chemistry, polymer industry, and biology. In this paper, we have performed the density function theory calculation along with atom in molecule analysis, molecular dynamics simulation as well as IR measurements of the bulk mono fluoro-ethanol (MFE) and compared them with the bulk ethanol (ETH) in order to understand the effect of fluorocarbon group in the structure as well as hydrogen bond network of the bulk MFE...
January 18, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28099009/thickness-controlled-quasi-two-dimensional-colloidal-pbse-nanoplatelets
#18
Weon-Kyu Koh, Naveen Kumar Dandu, Andrew F Fidler, Victor I Klimov, Jeffrey M Pietryga, Svetlana V Kilina
We demonstrate controlled synthesis of discrete two-dimensional (2D) PbSe nanoplatelets (NPLs), with measureable photoluminescence, via oriented attachment directed by quantum dot (QD) surface chemistry. Halide passivation is critical to the growth of these (100) face-dominated NPLs, as corroborated by density functional theory studies. PbCl2 moieties attached to the (111) and (110) of small nanocrystals form interparticle bridges, aligning the QDs and leading to attachment. We find that a 2D bridging network is energetically favored over a 3D network, driving the formation of NPLs...
January 18, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28098750/cluster-based-maximum-consensus-time-synchronization-for-industrial-wireless-sensor-networks
#19
Zhaowei Wang, Peng Zeng, Mingtuo Zhou, Dong Li, Jintao Wang
Time synchronization is one of the key technologies in Industrial Wireless Sensor Networks (IWSNs), and clustering is widely used in WSNs for data fusion and information collection to reduce redundant data and communication overhead. Considering IWSNs' demand for low energy consumption, fast convergence, and robustness, this paper presents a novel Cluster-based Maximum consensus Time Synchronization (CMTS) method. It consists of two parts: intra-cluster time synchronization and inter-cluster time synchronization...
January 13, 2017: Sensors
https://www.readbyqxmd.com/read/28098177/an-extended-n-h-bond-driven-by-a-conserved-second-order-interaction-orients-the-flavin-n5-orbital-in-cholesterol-oxidase
#20
Emily Golden, Li-Juan Yu, Flora Meilleur, Matthew P Blakeley, Anthony P Duff, Amir Karton, Alice Vrielink
The protein microenvironment surrounding the flavin cofactor in flavoenzymes is key to the efficiency and diversity of reactions catalysed by this class of enzymes. X-ray diffraction structures of oxidoreductase flavoenzymes have revealed recurrent features which facilitate catalysis, such as a hydrogen bond between a main chain nitrogen atom and the flavin redox center (N5). A neutron diffraction study of cholesterol oxidase has revealed an unusual elongated main chain nitrogen to hydrogen bond distance positioning the hydrogen atom towards the flavin N5 reactive center...
January 18, 2017: Scientific Reports
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