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"Propensity score" statin

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https://www.readbyqxmd.com/read/29781295/impact-of-statin-use-on-recurrence-or-survival-after-surgical-curative-resection-of-non-small-cell-lung-cancer
#1
Tak Kyu Oh, Kwhanmien Kim, Sanghoon Jheon, Jaebong Lee, Sang-Hwan Do, Jung-Won Hwang, Hyo Jin Kim, In-Ae Song
Statins are known for their anticancer effects, and many studies have shown the effectiveness of statins for cancer prevention and improvement of cancer-related long-term oncologic outcome. However, their effectiveness on recurrence or survival of non-small cell lung cancer (NSCLC) after curative resection remains unknown. This was a retrospective cohort study that assessed the medical records of patients who were diagnosed with NSCLC and treated with curative resection at a tertiary care hospital between August 2003 and July 2012...
January 2018: Cancer Control: Journal of the Moffitt Cancer Center
https://www.readbyqxmd.com/read/29765224/statins-use-and-risk-of-new-onset-diabetes-in-hypertensive-patients-a-population-based-retrospective-cohort-study-in-yinzhou-district-ningbo-city-people-s-republic-of-china
#2
Hailong Li, Hongbo Lin, Houyu Zhao, Yang Xu, Yinchu Cheng, Peng Shen, Siyan Zhan
Background: Reports have suggested that statin use is associated with an increased incidence of type 2 diabetes mellitus (T2DM). Guidelines suggested that statins should be prescribed in hypertensive patients for primary prevention. However, there were very few studies on the risk of T2DM associated with statin use among patients with hypertension in mainland People's Republic of China. Purpose: To determine the association between statin use and new-onset diabetes mellitus among patients with hypertension in mainland People's Republic of China...
2018: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29758993/lower-in-hospital-ventricular-tachyarrhythmia-in-patients-with-acute-myocardial-infarction-receiving-prior-statin-therapy
#3
Jin Sup Park, Bo Won Kim, Taek Jong Hong, Jeong Cheon Choe, Hye Won Lee, Jun-Hyok Oh, Jung Hyun Choi, Han Cheol Lee, Kwang Soo Cha, Myung Ho Jeong
We evaluated whether prior statin therapy reduces in-hospital ventricular tachycardia/ventricular fibrillation (VT/VF) in percutaneous coronary intervention (PCI) patients with acute myocardial infarction (MI). Among the 1177 patients from the Acute Myocardial Infarction Registry-National Institutes of Health (KAMIR-NIH), 823 (70%) patients received prior statin therapy. Prior statin therapy was associated with a reduced risk of VT/VF events in both adjusted propensity score analysis (odds ratio [OR] 0.414, 95% confidence interval [CI], 0...
January 1, 2018: Angiology
https://www.readbyqxmd.com/read/29713254/long-term-survival-benefit-of-statin-in-patients-with-coronary-chronic-total-occlusion-without-revascularization
#4
Bum Sung Kim, Jeong Hoon Yang, Woo Jin Jang, Young Bin Song, Joo-Yong Hahn, Jin-Ho Choi, Ki Hong Choi, Sung-Hea Kim, Woo Jung Chun, Hyeon-Cheol Gwon, Seung-Hyuk Choi
Background: Limited data are available on the efficacy of statin therapy in stable ischemic heart disease with chronic total occlusion (CTO) without revascularization. We investigated whether statin therapy could be beneficial in stable patients with CTO without revascularization. Methods: From March 2003 to February 2012, 2,024 patients with at least one CTO were enrolled in a retrospective, single-center registry; 664 of these patients were managed conservatively without an initial revascularization strategy...
April 30, 2018: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/29673426/statins-and-musculoskeletal-conditions-in-u-s-air-force-active-duty-aviators
#5
Anthony P Tvaryanas, Joseph H Wagner, Genny M Maupin
BACKGROUND: The purpose of this study was to examine the association of statin use and musculoskeletal conditions within the population of U.S. Air Force active duty aviators. METHODS: The study was a retrospective cohort analysis of aviators between 2004-2014 as identified from personnel data. Based on pharmacy data, participants were divided into two groups: statin users (received a statin for at least 90 d) and nonusers (never received a statin throughout the study period)...
May 1, 2018: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/29659717/statin-treatment-is-associated-with-a-neutral-effect-on-health-related-quality-of-life-among-community-dwelling-octogenarian-men
#6
Timo E Strandberg, Annele Urtamo, Juuso Kähärä, Arto Y Strandberg, Kaisu H Pitkälä, Hannu Kautiainen
Background: Statin treatment is common among 80+ people, but little is known about statin effects on health-related quality of life (HRQoL) in this oldest age group. Methods: In the Helsinki Businessmen Study (HBS), men born 1919 to 1934 (original n=3490), have been followed-up since the 1960s. In 2015, a questionnaire about lifestyle, diseases and medications, and including RAND-36/SF-36 HRQoL instrument was mailed to survivors. 612 men (72.6%) responded, 530 of them reporting their medications (98% community-living)...
April 12, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29622625/lipid-lowering-agents-and-high-hdl-high-density-lipoprotein-are-inversely-associated-with-intracranial-aneurysm-rupture
#7
Anil Can, Victor M Castro, Dmitriy Dligach, Sean Finan, Sheng Yu, Vivian Gainer, Nancy A Shadick, Guergana Savova, Shawn Murphy, Tianxi Cai, Scott T Weiss, Rose Du
BACKGROUND AND PURPOSE: Growing evidence from experimental animal models and clinical studies suggests the protective effect of statin use against rupture of intracranial aneurysms; however, results from large studies detailing the relationship between intracranial aneurysm rupture and total cholesterol, HDL (high-density lipoprotein), LDL (low-density lipoprotein), and lipid-lowering agent use are lacking. METHODS: The medical records of 4701 patients with 6411 intracranial aneurysms diagnosed at the Massachusetts General Hospital and the Brigham and Women's Hospital between 1990 and 2016 were reviewed and analyzed...
April 5, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29580855/statin-therapy-is-associated-with-higher-long-term-but-not-perioperative-survival-after-abdominal-aortic-aneurysm-repair
#8
Thomas F X O'Donnell, Sarah E Deery, Katie E Shean, Murray A Mittleman, Jeremy D Darling, Mohammad H Eslami, Randall R DeMartino, Marc L Schermerhorn
BACKGROUND: Although preoperative and perioperative statin therapy improves postoperative outcomes in several populations, few data examine its association with survival after abdominal aortic aneurysm (AAA) repair. In addition, no data exist regarding the benefits of starting statins in patients with AAA not currently taking them. METHODS: We performed a registry-based study of all patients undergoing repair of AAAs in the Vascular Quality Initiative between 2003 and 2017 without documented statin intolerance...
March 23, 2018: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29540427/prognostic-impact-of-statin-intensity-in-heart-failure-patients-with-ischemic-heart-disease-a-report-from-the-chart-2-chronic-heart-failure-registry-and-analysis-in-the-tohoku-district-2-study
#9
Takuya Oikawa, Yasuhiko Sakata, Kotaro Nochioka, Masanobu Miura, Kanako Tsuji, Takeo Onose, Ruri Abe, Shintaro Kasahara, Masayuki Sato, Takashi Shiroto, Jun Takahashi, Satoshi Miyata, Hiroaki Shimokawa
BACKGROUND: The beneficial prognostic impact of statins has been established in patients with ischemic heart disease but not in those with heart failure (HF). In addition, it is still unclear whether patients benefit from statins regardless of low-density lipoprotein cholesterol levels. METHODS AND RESULTS: We examined 2444 consecutive stage C or D HF patients with ischemic heart disease registered in CHART-2 (Chronic Heart Failure Registry and Analysis in the Tohoku District 2), a multicenter, prospective, observational cohort study in Japan...
March 14, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29497861/obesity-paradox-in-prostate-cancer-increased-body-mass-index-was-associated-with-decreased-risk-of-metastases-after-surgery-in-13-667-patients
#10
Jonas Schiffmann, Pierre I Karakiewicz, Michael Rink, L Manka, Georg Salomon, Derya Tilki, Lars Budäus, Raisa Pompe, Sami-Ramzi Leyh-Bannurah, Alexander Haese, P Hammerer, Hartwig Huland, Markus Graefen, Pierre Tennstedt
INTRODUCTION: Obesity might negatively affect prostate cancer (PCa) outcomes. However, evidence according to the associations between obesity and metastases-free survival after radical prostatectomy (RP) is still inconsistent. METHODS: We relied on PCa patients treated with RP at the Martini-Klinik Prostate Cancer Center between 2004 and 2015. First, multivariable Cox regression analyses examined the impact of obesity on metastases after RP. Last, in a propensity score matched cohort, Kaplan-Meier analyses assessed metastases-free survival according to body mass index (kg/m2 ) (BMI) strata (≥ 30 vs...
March 2, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29495236/-impact-of-different-intervention-models-on-adherence-to-secondary-prevention-therapies-in-patients-with-acute-coronary-syndrome
#11
J Liu, W Wang, J Liu, Y Wang, Y Qi, J Y Sun, D Zhao
Objective: To evaluate the impact of different intervention models on adherence to secondary prevention therapies in patients with acute coronary syndrome (ACS). Methods: This multi-center cross-sectional study collected data from 34 hospitals covering 22 provinces in China. Hospitals were randomly divided into four groups: control group(routine treatment and care), promotional calendar group (routine treatment and care plus giving propaganda desk calendar to patients), education group (routine treatment and care add patients education by nurses) and combined intervention group (promotional calendar and education)...
February 24, 2018: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/29491327/effects-of-statin-intensity-on-clinical-outcome-in-acute-myocardial-infarction-patients
#12
Doyeon Hwang, Hyun Kuk Kim, Joo Myung Lee, Ki Hong Choi, Jihoon Kim, Tae-Min Rhee, Jonghanne Park, Taek Kyu Park, Jeong Hoon Yang, Young Bin Song, Jin-Ho Choi, Joo-Yong Hahn, Seung-Hyuk Choi, Bon-Kwon Koo, Young Jo Kim, Shung Chull Chae, Myeong Chan Cho, Chong Jin Kim, Hyeon-Cheol Gwon, Myung Ho Jeong, Hyo-Soo Kim
BACKGROUND: There has been debate regarding the added benefit of high-intensity statins compared with low-moderate-intensity statins, especially in patients with acute myocardial infarction (AMI).Methods and Results:The Korea Acute Myocardial Infarction Registry-National Institutes of Health consecutively enrolled 13,104 AMI patients. Of these, a total of 12,182 patients, who completed 1-year follow-up, were included in this study, and all patients were classified into 3 groups (no statin; low-moderate-intensity statin; and high-intensity statin)...
March 23, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/29428155/statin-medications-are-associated-with-decreased-risk-of-sepsis-and-anastomotic-leaks-after-rectal-resections
#13
David Disbrow, Corie L Seelbach, Jeremy Albright, Jane Ferraro, Juan Wu, Jon M Hain, Beth-Ann Shanker, Robert K Cleary
BACKGROUND: This study was designed to determine the effect of statins on colorectal postoperative complications related to sepsis. Previous studies have reported conflicting results. METHODS: This is a retrospective propensity score analysis of postoperative outcomes from a large regional database of patients who underwent elective colorectal resection from June 2012-July 2015. RESULTS: 7285 patients met inclusion criteria: 34.5% received statins...
January 31, 2018: American Journal of Surgery
https://www.readbyqxmd.com/read/29400081/association-of-statin-therapy-with-risk-of-epilepsy-in-2-propensity-score-matched-cohorts
#14
Lakshya U Trivedi, Carlos A Alvarez, Ishak A Mansi
BACKGROUND: Studies have suggested that statins may have a neuroprotective effect against epilepsy. However, evidence from rat models and case reports have suggested an opposite effect. Overall data are limited. OBJECTIVE: To examine the association between statin use and epilepsy risk in a general population and in a healthy population (individuals with no severe comorbidities). METHODS: Patients were Tricare beneficiaries from October 2003 to March 2012...
February 1, 2018: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/29380457/new-statin-use-and-left-ventricular-structure-estimating-long-term-associations-in-the-multi-ethnic-study-of-atherosclerosis-mesa
#15
Lauren N Strand, Rebekah L Young, Alain G Bertoni, David A Bluemke, Gregory L Burke, Joao A Lima, Nona Sotoodehnia, Bruce M Psaty, Robyn L McClelland, Susan R Heckbert, Joseph A Delaney
PURPOSE: Only small and short-term studies have evaluated statins in relation to changes in heart structure. We estimated the association between new statin use and 10-year remodeling of the left ventricle. METHODS: The Multi-Ethnic Study of Atherosclerosis collected data on statin use over approximately 10 years, conducting cardiac magnetic resonance (CMR) imaging at baseline and the 10-year exam. Participants were free of baseline cardiovascular disease, and we excluded users of statins at baseline...
January 30, 2018: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/29355073/estimating-causal-log-odds-ratio-using-the-case-control-sample-and-its-application-in-the-pharmaco-epidemiology-study
#16
Anqi Zhu, Donglin Zeng, Pengyue Zhang, Lang Li
One important goal in pharmaco-epidemiology studies is to understand the causal relationship between drug exposures and their clinical outcomes, including adverse drug events. In order to achieve this goal, however, we need to resolve several challenges. Most of pharmaco-epidemiology data are observational and confounding is largely present due to many co-medications. The pharmaco-epidemiology study data set is often sampled from large medical record databases using a matched case-control design, and it may not be representative of the original patient population in the medical record databases...
January 1, 2018: Statistical Methods in Medical Research
https://www.readbyqxmd.com/read/29349709/the-host-response-in-critically-ill-sepsis-patients-on-statin-therapy-a-prospective-observational-study
#17
Maryse A Wiewel, Brendon P Scicluna, Lonneke A van Vught, Arie J Hoogendijk, Aeilko H Zwinderman, René Lutter, Janneke Horn, Olaf L Cremer, Marc J Bonten, Marcus J Schultz, Tom van der Poll
BACKGROUND: Statins can exert pleiotropic anti-inflammatory, vascular protective and anticoagulant effects, which in theory could improve the dysregulated host response during sepsis. We aimed to determine the association between prior statin use and host response characteristics in critically ill patients with sepsis. METHODS: We performed a prospective observational study in 1060 patients admitted with sepsis to the mixed intensive care units (ICUs) of two hospitals in the Netherlands between January 2011 and July 2013...
January 18, 2018: Annals of Intensive Care
https://www.readbyqxmd.com/read/29349644/does-statin-benefits-patients-with-heart-failure-undergoing-percutaneous-coronary-intervention-findings-from-the-melbourne-interventional-group-registry
#18
Ken Lee Chin, Rory Wolfe, Christopher M Reid, Andrew Tonkin, Ingrid Hopper, Angela Brennan, Nick Andrianopoulos, Stephen J Duffy, David Clark, Andrew Ajani, Danny Liew
PURPOSE: The effectiveness of statins in improving clinical outcomes among patients with heart failure (HF) undergoing percutaneous coronary intervention (PCI) is unclear. We examined the association between use of statins and clinical outcomes in patients with HF included in the Melbourne Interventional Group registry. METHODS: Patients were followed from 30 days to 1 year post-PCI for a primary composite outcome of all-cause mortality and hospitalisation for cardiovascular (CV) causes...
February 2018: Cardiovascular Drugs and Therapy
https://www.readbyqxmd.com/read/29341172/statin-use-and-the-risk-of-cardiovascular-implantable-electronic-device-infection-a-cohort-study-in-a-veteran-population
#19
Talal Alzahrani, Angelike P Liappis, Larry M Baddour, Pamela E Karasik
BACKGROUND: The rate of cardiovascular implantable electronic device infection (CIEDI) has increased, despite the use of perioperative antibiotics at the time of device placement or revision. This is due, in part, to the presence of multiple comorbid conditions in an elderly population, in general, who require CIED. Statins may have an antibacterial effect, although there is currently no evidence that the likelihood of CIEDI has been impacted by statin use. METHODS: A retrospective cohort study was performed to assess whether statins are associated with a reduced risk of CIEDI...
January 17, 2018: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/29330214/association-of-statin-dose-with-amputation-and-survival-in-patients-with-peripheral-artery-disease
#20
Shipra Arya, Anjali Khakharia, Zachary O Binney, Randall R DeMartino, Luke P Brewster, Philip P Goodney, Peter W F Wilson
BACKGROUND: Statin dose guidelines for patients with peripheral artery disease (PAD) are largely based on coronary artery disease and stroke data. The aim of this study is to determine the effect of statin intensity on PAD outcomes of amputation and mortality. METHODS: Using an observational cohort study design and a validated algorithm, we identified patients with incident PAD (2003-2014) in the national Veterans Affairs data. Highest statin intensity exposure (high-intensity versus low-to-moderate-intensity versus antiplatelet therapy but no statin use) was determined within 1 year of diagnosis of PAD...
April 3, 2018: Circulation
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