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"Propensity score" statin

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https://www.readbyqxmd.com/read/29138182/disparities-in-the-quality-of-cardiovascular-care-between-hiv-infected-versus-hiv-uninfected-adults-in-the-united-states-a-cross-sectional-study
#1
Joseph A Ladapo, Adam K Richards, Cassandra M DeWitt, Nina T Harawa, Steven Shoptaw, William E Cunningham, John N Mafi
BACKGROUND: Cardiovascular disease is emerging as a major cause of morbidity and mortality among patients with HIV. We compared use of national guideline-recommended cardiovascular care during office visits among HIV-infected versus HIV-uninfected adults. METHODS AND RESULTS: We analyzed data from a nationally representative sample of HIV-infected and HIV-uninfected patients aged 40 to 79 years in the National Ambulatory Medical Care Survey/National Hospital Ambulatory Medical Care Survey, 2006 to 2013...
November 14, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29121292/preadmission-statin-use-improves-the-outcome-of-less-severe-sepsis-patients-a-population-based-propensity-score-matched-cohort-study
#2
M G Lee, C-C Lee, C-C Lai, T-C Hsu, L Porta, M Lee, S-S Chang, K-L Chien, Y-M Chen
Background: Randomized controlled trials on the post-admission use of statins in sepsis patients have not shown a survival benefit. Whether preadmission use of statins would confer any beneficial effects in sepsis patients has not been well studied. Methods: We conducted a population-based cohort study on a national health insurance claims database between 1999 and 2011. Sepsis patients were identified by ICD-9 codes compatible with the third International consensus definitions for sepsis...
October 1, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/29095423/association-of-statins-with-decreased-acute-pancreatitis-severity-a-propensity-score-analysis
#3
Peter J Lee, Kunjam Modha, Tiffany Chua, Amitabh Chak, Daniel Jang, Rocio Lopez, Amir Gougol, Georgios I Papachristou, Tyler Stevens
BACKGROUND: Statins possess anti-inflammatory properties and have a protective effect in certain inflammatory conditions; however, their effect on the natural history of pancreatitis is unknown. AIM: The aim of this study is to assess the effect of statin exposure on the severity of pancreatitis and incidence of organ failure using a propensity-matched approach. METHODS: A historical cohort study was conducted of adult patients with acute pancreatitis (AP) admitted in the Cleveland Clinic Health System between 2007 and 2014...
October 31, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/29081488/statin-use-is-associated-with-a-reduced-risk-of-hepatocellular-carcinoma-recurrence-after-initial-liver-resection
#4
Yoshikuni Kawaguchi, Yoshihiro Sakamoto, Daisuke Ito, Kyoji Ito, Junichi Arita, Nobuhisa Akamatsu, Junichi Kaneko, Kiyoshi Hasegawa, Kyoji Moriya, Norihiro Kokudo
Effective adjuvant therapies have not been established for hepatocellular carcinoma (HCC). The study aimed to determine prognostic influence of statin against HCC recurrence after initial resection. From 2003 to 2013, 734 patients underwent initial HCC resection. Exposure to statins was defined as the use at the recommended daily dosage for > 90 days after surgery. Outcomes were compared between patients who did and did not receive statins. Of 734 patients, 31 (4.2%) received statins for dyslipidemia (statin group) and 703 (95...
October 29, 2017: Bioscience Trends
https://www.readbyqxmd.com/read/29081029/do-statins-increase-the-risk-of-esophageal-conditions-findings-from-four-propensity-score-matched-analyses
#5
Ioana Smith, Robert Schmidt, Ethan A Halm, Ishak A Mansi
BACKGROUND AND OBJECTIVE: Statins are commonly used medications. Whereas some observational studies suggested an association of statin use with Barrett's esophagus and some upper gastrointestinal symptoms, there is a dearth of data on the association of statins and common esophageal conditions such as gastroesophageal reflux disease and esophagitis. The aim of this study is to examine the association of statins with esophageal conditions. METHODS: This is a retrospective cohort study using regional military healthcare data (1 October, 2003 to 1 March, 2012)...
October 28, 2017: Clinical Drug Investigation
https://www.readbyqxmd.com/read/29073212/statins-and-new-onset-atrial-fibrillation-in-a-cohort-of-patients-with-hypertension-analysis-of-electronic-health-records-2006-2015
#6
Lia Alves-Cabratosa, Maria García-Gil, Marc Comas-Cufí, Anna Ponjoan, Ruth Martí-Lluch, Dídac Parramon, Jordi Blanch, Marc Elosua-Bayes, Rafel Ramos
Hypertension is the most prevalent risk factor for new-onset atrial fibrillation (AF). But few studies have addressed the effect of statins on the incidence of this arrhythmia in patients with hypertension. This study aimed to evaluate the effect of statins on new-onset of this arrhythmia in a hypertensive population, accounting for AF risk. Data from the Information System for the Development of Research in Primary Care was used to recruit a retrospective cohort of ≥55-year-old hypertensive individuals with no ischemic vascular disease, in 2006-2007, followed up through 2015...
2017: PloS One
https://www.readbyqxmd.com/read/29024975/comparing-methods-to-address-bias-in-observational-data-statin-use-and-cardiovascular-events-in-a-us-cohort
#7
Paulina Kaiser, Alice M Arnold, David Benkeser, Adina Zeki Al Hazzouri, Calvin H Hirsch, Bruce M Psaty, Michelle C Odden
Background: The theoretical conditions under which causal estimates can be derived from observational data are challenging to achieve in the real world. Applied examples can help elucidate the practical limitations of methods to estimate randomized-controlled trial effects from observational data. Methods: We used six methods with varying design and analytic features to compare the 5-year risk of incident myocardial infarction among statin users and non-users, and used non-cardiovascular mortality as a negative control outcome...
September 8, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29021777/circulating-cholesterol-levels-may-link-to-the-factors-influencing-parkinson-s-risk
#8
Lijun Zhang, Xue Wang, Ming Wang, Nick W Sterling, Guangwei Du, Mechelle M Lewis, Tao Yao, Richard B Mailman, Runze Li, Xuemei Huang
OBJECTIVES: A growing literature suggests that circulating cholesterol levels have been associated with Parkinson's disease (PD). In this study, we investigated a possible causal basis for the cholesterol-PD link. METHODS: Fasting plasma cholesterol levels were obtained from 91 PD and 70 age- and gender-matched controls from an NINDS PD Biomarkers Program cohort at the Pennsylvania State University College of Medicine. Based on the literature, genetic polymorphisms in selected cholesterol management genes (APOE, LDLR, LRP1, and LRPAP1) were chosen as confounding variables because they may influence both cholesterol levels and PD risk...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29020184/risk-of-acute-liver-injury-after-statin-initiation-by-human-immunodeficiency-virus-and-chronic-hepatitis-c-virus-infection-status
#9
Dana D Byrne, Janet P Tate, Kimberly A Forde, Joseph K Lim, Matthew Bidwell Goetz, David Rimland, Maria C Rodriguez-Barradas, Adeel A Butt, Cynthia L Gibert, Sheldon T Brown, Roger Bedimo, Matthew S Freiberg, Amy C Justice, Jay R Kostman, Jason A Roy, Vincent Lo Re
Background: Patients with human immunodeficiency virus (HIV) and/or chronic hepatitis C virus (HCV) infection may be prescribed statins as treatment for metabolic/cardiovascular disease, but it remains unclear if the risk of acute liver injury (ALI) is increased for statin initiators compared to nonusers in groups classified by HIV/HCV status. Methods: We conducted a cohort study to compare rates of ALI in statin initiators vs nonusers among 7686 HIV/HCV-coinfected, 8155 HCV-monoinfected, 17739 HIV-monoinfected, and 36604 uninfected persons in the Veterans Aging Cohort Study (2000-2012)...
August 16, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28985950/moderate-to-high-intensity-statin-in-dialysis-patients-after-acute-myocardial-infarction-a-national-cohort-study-in-asia
#10
Chang-Min Chung, Ming-Shyan Lin, Chih-Hsiang Chang, Hui-Wen Cheng, Shih-Tai Chang, Po-Chang Wang, Hung-Yu Chang, Yu-Sheng Lin
BACKGROUND AND AIMS: Statin is not beneficial for dialysis patients but moderate to high intensity statin is beneficial for patients after acute myocardial infarction (MI). The aim of this study was to evaluate the effect of moderate to high intensity statin on mortality, cardiovascular outcomes in dialysis patients after acute MI. METHODS: Data on dialysis patients were retrieved from the National Health Insurance Research Database in Taiwan. Dialysis patients admitted for MI were selected and divided into two groups according to statin prescription or not after MI...
September 27, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28962887/a-population-based-cohort-study-on-the-drug-specific-effect-of-statins-on-sepsis-outcome
#11
Chien-Chang Lee, Meng-Tse Gabriel Lee, Tzu-Chun Hsu, Lorenzo Porta, Shy-Shin Chang, Chia-Hung Yo, Kuang-Chau Tsai, Matthew Lee
BACKGROUND: Whether statin treatment, proved by recent experimental studies to have an antimicrobial activity, exerts a drug- or a class-specific effect in sepsis remains unknown. METHODS: Short-term mortality in patients with sepsis was analyzed using data from the National Health Insurance Research Database. Use of statins was defined as the cumulative use of a specific statin (atorvastatin, simvastatin, or rosuvastatin) for > 30 days prior to the index sepsis admission...
September 27, 2017: Chest
https://www.readbyqxmd.com/read/28951019/statin-therapy-in-patients-with-low-serum-levels-of-low-density-lipoprotein-cholesterol
#12
Tetsuro Tsujimoto, Hiroshi Kajio, Takehiro Sugiyama
Recommendations for the management of low-density lipoprotein cholesterol (LDL-C) and the strategy of statin therapy differ between current guidelines. We performed a prospective cohort study using data from the National Health and Nutrition Examination Survey from 1999 to 2010. For all-cause, cardiovascular, and noncardiovascular mortalities, we used Cox proportional hazards models to analyze unadjusted and multivariable-adjusted hazard ratios (HRs). We included age, gender, race and ethnicity, educational attainment, smoking status, body mass index, previous history of cardiovascular disease and cancer, diabetes, hypertension, LDL-C levels, high-density lipoprotein cholesterol levels, log-transferred triglyceride levels, estimated glomerular filtration rate levels, and the presence or absence of macroalbuminuria for the adjustment...
August 30, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28940673/statins-reduce-the-risk-of-liver-decompensation-and-death-in-chronic-viral-hepatitis-a-propensity-score-weighted-landmark-analysis
#13
J C-T Wong, H L-Y Chan, Y-K Tse, T C-F Yip, V W-S Wong, G L-H Wong
BACKGROUND: Decompensated liver disease due to portal hypertension leads to significant morbidity and mortality. Statins can modulate intrahepatic vascular tone, but the clinical significance remains uncertain. AIM: To determine the effects of statin use on the risk of liver decompensation and death among patients with chronic viral hepatitis. METHODS: We conducted a population wide cohort study using a hospital based database from the Hong Kong Hospital Authority...
November 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28927294/treatment-of-patients-with-myocardial-infarction-depends-on-history-of-cancer
#14
Sabine Rohrmann, Fabienne Witassek, Paul Erne, Hans Rickli, Dragana Radovanovic
BACKGROUND: Although cancer treatment considerably affects cardiovascular health, little is known about how cancer patients are treated for an acute myocardial infarction. We aimed to investigate whether acute myocardial infarction patients with a history of cancer received the same guideline recommended treatment as those acute myocardial infarction patients without and whether they differ with respect to inhospital outcome. METHODS: All patients with ST-segment elevation myocardial infarction and non-ST-segment elevation myocardial infarction, enrolled between 2002 and mid-2015 in the acute myocardial infarction in Switzerland (AMIS Plus) registry with comorbidity data based on the Charlson comorbidity index were analysed...
September 1, 2017: European Heart Journal. Acute Cardiovascular Care
https://www.readbyqxmd.com/read/28920927/no-impact-of-preadmission-anti-inflammatory-drug-use-on-risk-of-depression-and-anxiety-after-critical-illness
#15
Clara R Medici, Jaimie L Gradus, Lars Pedersen, Henrik T Sørensen, Søren D Østergaard, Christian F Christiansen
OBJECTIVES: Risk of depression and anxiety is elevated after intensive care. Drugs with anti-inflammatory properties may have antidepressant and anxiolytic effects. The aim of this study was to investigate the association between preadmission use of drugs with anti-inflammatory effects and risk of new-onset depression and anxiety among adult patients admitted to an ICU. DESIGN: Propensity score-matched, population-based cohort study. SETTING: All ICUs in Denmark from 2005 to 2013...
October 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28892121/statins-for-primary-prevention-of-cardiovascular-events-and-mortality-in-older-men
#16
Ariela R Orkaby, J Michael Gaziano, Luc Djousse, Jane A Driver
BACKGROUND/OBJECTIVES: We sought to determine whether statin use for primary prevention is associated with a lower risk of cardiovascular events or mortality in older men. DESIGN: Prospective cohort study. SETTING: Physicians' Health Study participants. PARTICIPANTS: 7,213 male physicians ≥70 years without a history of cardiovascular disease (CVD). MEASUREMENTS: Multivariable propensity score for statin use with greedy matching (1:1) to minimize confounding by indication...
November 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28885959/statins-and-musculoskeletal-conditions-in-u-s-air-force-active-duty-service-members
#17
Anthony P Tvaryanas, Joseph H Wagner, Genny M Maupin, Valarie M Schroeder
BACKGROUND: This study examined the association of statin use and musculoskeletal conditions in statin users and nonusers within the population of U.S. Air Force active duty Service members in the military health care system. METHODS: The study was a retrospective cohort analysis of Service members between 2004 and 2014 as identified from personnel data having physical fitness and cardiac risk data available and who were free of musculoskeletal diagnoses for 6 months before the study period...
September 2017: Military Medicine
https://www.readbyqxmd.com/read/28880449/reduced-risk-of-decompensation-and-death-associated-with-use-of-statins-in-patients-with-alcoholic-cirrhosis-a-nationwide-case-cohort-study
#18
U C Bang, T Benfield, F Bendtsen
BACKGROUND: Reports have indicated that the use of statins may ameliorate the course of cirrhosis. AIM: To determine the relationship between use of statins and mortality rate in patients with cirrhosis. METHODS: We did a retrospective case-cohort analysis based on data from the Danish registers from the period 1995 through 2014. Index date was time of diagnosis of cirrhosis (ICD-10: K703) and cohort entry depended on whether the patient was statin user or not...
October 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28858077/evaluation-of-the-impact-of-statin-therapy-on-the-obesity-paradox-in-patients-with-acute-myocardial-infarction-a-propensity-score-matching-analysis-from-the-korea-acute-myocardial-infarction-registry
#19
Ki-Bum Won, Seung-Ho Hur, Chang-Wook Nam, Soe Hee Ann, Gyung-Min Park, Sang-Gon Lee, Hyo-Eun Kim, Yun-Kyeong Cho, Hyuck-Jun Yoon, Hyoung-Seob Park, Hyungseop Kim, Seongwook Han, Myung-Ho Jeong, Young-Keun Ahn, Seung-Woon Rha, Chong-Jin Kim, Myeong-Chan Cho, Hyo-Soo Kim, Shung-Chull Chae, Kee-Sik Kim, Young-Jo Kim, Kwon-Bae Kim, Philip Barter
The phenomenon of obesity paradox after acute myocardial infarction (AMI) has been reported under strong recommendation of statin therapy. However, the impact of statin therapy on this paradox has not been investigated. This study investigated the impact of statin therapy on 1-year mortality according to obesity after AMI. A total of 2745 AMI patients were included from the Korea Acute Myocardial Infarction Registry after 1:4 propensity score matching analysis (n = 549 for nonstatin group and n = 2196 for statin group)...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28835175/beneficial-effect-of-statins-on-total-mortality-in-abdominal-aortic-aneurysm-aaa-repair
#20
COMPARATIVE STUDY
Sven Ross Mathisen, Michael Abdelnoor
In this single center, retrospective cohort study we wished to compare early and total mortality for all patients treated for abdominal aortic aneurysms (AAA) with open surgery who were taking statins compared to those who were not. A cohort of 640 patients with AAA was treated with open surgery between 1999 and 2012. Patients were consecutively recruited from a source population of 390,000; 21.3% were female, and the median age was 73 years. The median follow-up was 3.93 years, with an interquartile range of 1...
October 2017: Vascular Medicine
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