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https://www.readbyqxmd.com/read/29909576/comparative-risks-of-bleeding-ischemic-stroke-and-mortality-with-direct-oral-anticoagulants-versus-phenprocoumon-in-patients-with-atrial-fibrillation
#1
Mariam Ujeyl, Ingrid Köster, Hans Wille, Thomas Stammschulte, Rebecca Hein, Sebastian Harder, Ursula Gundert-Remy, Julian Bleek, Peter Ihle, Helmut Schröder, Gerhard Schillinger, Anette Zawinell, Ingrid Schubert
PURPOSE: The pivotal trials for stroke prevention in non-valvular atrial fibrillation (NVAF) compared rivaroxaban, dabigatran, and apixaban with warfarin, as did most claims-based studies. Comparisons with phenprocoumon, the most frequently used vitamin K antagonist (VKA) in Germany, are scarce. METHODS: Risk of bleeding, ischemic stroke, and all-cause mortality in patients with NVAF were analyzed using data for 2010 to 2014 from a large German claims database. New users of oral anticoagulants from January 2012 to December 2013 were included and observed over 1 year...
June 16, 2018: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29909141/new-onset-diabetes-after-androgen-deprivation-therapy-for-prostate-cancer-a-nationwide-propensity-score-matched-four-year-longitudinal-cohort-study
#2
Jhen-Hao Jhan, Hsin-Chih Yeh, Yu-Han Chang, Shiao-Jin Guu, Wen-Jeng Wu, Yii-Her Chou, Ching-Chia Li
INTRODUCTION: Androgen-deprivation therapy (ADT) is important in the treatment of prostate cancer. However, the relationship between ADT and the risk of diabetes remains unclear, and the association between duration and types of ADT has not been fully investigated. AIM: To examine the risk of developing type 2 diabetes mellitus (T2DM) in men who underwent ADT for prostate cancer. METHODS: Data were collected retrospectively from the Longitudinal Health Insurance Database of Taiwan...
March 22, 2018: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/29909089/safety-of-laparoscopic-surgery-for-benign-diseases-during-pregnancy-a-nationwide-retrospective-cohort-study
#3
Daisuke Shigemi, Shotaro Aso, Hiroki Matsui, Kiyohide Fushimi, Hideo Yasunaga
STUDY OBJECTIVE: To compare fetal, maternal, and operative outcomes of laparoscopic surgery versus laparotomy for major benign diseases including appendicitis, cholecystitis, adnexal masses, and uterine myoma during pregnancy. DESIGN: Retrospective cohort study (Canadian Task Force classification II-2). SETTING: The Diagnosis Procedure Combination database, a national inpatient database for acute-care inpatients in Japan. PATIENTS: 6,018 eligible patients underwent abdominal surgery (4,047 laparotomy and 1,971 laparoscopy patients) from July 2010 through March 2016...
June 14, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29908852/early-postoperative-hypoalbuminemia-is-a-risk-factor-for-postoperative-acute-kidney-injury-following-hip-fracture-surgery
#4
Kyun-Ho Shin, Seung-Beom Han
INTRODUCTION: Acute kidney injury (AKI) is a common and serious complication after hip fracture surgery in older adults. Hypoalbuminemia is a known independent risk factor for AKI. However, few studies have investigated the relationship between early postoperative hypoalbuminemia and AKI after hip fracture surgery. Therefore, we sought to determine the incidence of and risk factors for AKI and the effects of early postoperative hypoalbuminemia on AKI incidence after surgery for hip fractures, especially intertrochanteric fractures of the proximal femur...
May 2, 2018: Injury
https://www.readbyqxmd.com/read/29908411/transitions-through-stages-of-alcohol-involvement-the-potential-role-of-mood-disorders
#5
Rosa M Crum, Kerry M Green, Elizabeth A Stuart, Lareina N La Flair, Marc Kealhofer, Andrea S Young, Noa Krawczyk, Kayla N Tormohlen, Carla L Storr, Anika A H Alvanzo, Ramin Mojtabai, Lauren R Pacek, Bernadette A Cullen, Beth A Reboussin
INTRODUCTION: Although prior clinical and population-based studies have demonstrated comorbidity between mood and alcohol use disorders (AUD), there is a paucity of research assessing whether mood disorders predict transition across stages of alcohol involvement. METHOD: Hypothesizing that mood disorders predict transition across sex-specific alcohol involvement stages, we used prospective data from the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC), a nationally representative survey of US adults, which included male (n = 14,564) and female (n = 20,089) participants surveyed in 2001-2 and re-interviewed in 2004-5...
April 10, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29908406/peer-support-intervention-for-postpartum-depression-participant-satisfaction-and-program-effectiveness
#6
Betty-Shannon Prevatt, Evan M Lowder, Sarah L Desmarais
OBJECTIVE: Postpartum mood disorders represent a serious problem affecting 10-20% of women and support groups offer a promising intervention modality. The current study examined participant satisfaction with and effectiveness of a peer-facilitated postpartum support group. INTERVENTION: The program consists of a free, peer-support group, developed to increase social support and destigmatise postpartum mood symptoms. The weekly group is co-facilitated by former group attendees and maternal health professionals...
May 31, 2018: Midwifery
https://www.readbyqxmd.com/read/29907976/outcomes-of-domino-liver-transplantation-compared-to-deceased-donor-liver-transplantation-a-propensity-matching-approach
#7
Emily D Geyer, Candice Burrier, Dmitry Tumin, Don Hayes, Sylvester M Black, W Kenneth Washburn, Joseph D Tobias
INTRODUCTION: Domino liver transplantation (DLT) utilizes the explanted liver of one liver transplant recipient as a donor graft in another patient. While there may be unique risks associated with DLT, it is unclear if DLT has less favorable long term outcomes than deceased donor liver transplantation (DDLT). We used a propensity score matching approach to compare the outcomes of DLT recipients to DDLT recipients in a large national registry. METHODS: The United Network for Organ Sharing registry was queried for patients undergoing DLT or DDLT in 2002-2016...
June 15, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/29907656/temporal-trends-in-the-outcomes-of-dialysis-patients-admitted-with-acute-ischemic-stroke
#8
Fahad Alqahtani, Chalak O Berzingi, Sami Aljohani, Mohamed Al Hajji, Anas Diab, Muhammad Alvi, Khaled Boobes, Mohamad Alkhouli
BACKGROUND: There is a paucity of contemporary data on the characteristics and outcomes of acute ischemic stroke (AIS) in patients on maintenance dialysis. METHODS AND RESULTS: We used the nationwide inpatient sample to examine contemporary trends in the incidence, management patterns, and outcomes of AIS in dialysis patients. A total of 930 010 patients were admitted with AIS between 2003 and 2014, of whom 13 642 (1.5%) were on dialysis. Overall, the incidence of AIS among dialysis patients decreased significantly ( P trend <0...
June 15, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29907539/serum-trough-level-as-a-postmarketing-quality-measure-of-generic-vancomycin-products
#9
Ya-Wen Tsai, Yu-Chiang Wang, Shian-Sen Shie, Min-Chi Chen, Yhu-Chering Huang, Chih-Jung Chen
BACKGROUND: The vancomycin trough level (VTL) is the most widely used pharmacokinetic parameter for monitoring its clinical efficacy. Whether the VTL is affected in patients receiving different vancomycin products has not previously been determined. METHODS: From 2005 to 2015, five vancomycin products, including the innovator (designated as VAN-Lilly) and four generic versions (designated as VAN-A, VAN-B, VAN-C and VAN-D), were sequentially used in a teaching hospital...
June 2, 2018: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/29906680/an-updated-assessment-of-morbidity-and-mortality-following-skull-base-surgical-approaches
#10
Brittany N Burton, Jenny Q Hu, Aria Jafari, Richard D Urman, Ian F Dunn, W Linda Bi, Adam S DeConde, Rodney A Gabriel
OBJECTIVES: Updated multi-institutional database studies assessing perioperative risk factors on 30-day morbidity and mortality after skull base surgeries are limited. We aim to identify perioperative risk factors and report the incidence of 30-day morbidity and mortality in adult patients after skull base surgery. PATIENTS AND METHODS: We queried the 2007-2016 American College of Surgeons National Surgical Quality Improvement program database to identify patients who underwent anterior, middle, or posterior skull base surgery...
June 10, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29906615/studying-a-rare-disease-using-multi-institutional-research-collaborations-vs-big-data-where-lies-the-truth
#11
Aileen C Johnson, Cecilia G Ethun, Yuan Liu, Alexandra G Lopez-Aguiar, Thuy B Tran, George Poultsides, Valerie Grignol, J Harrison Howard, Meena Bedi, T Clark Gamblin, Jennifer Tseng, Kevin K Roggin, Konstantinos Chouliaras, Konstantinos Votanopoulos, Darren Cullinan, Ryan C Fields, Keith A Delman, William C Wood, Kenneth Cardona, Shishir K Maithel
BACKGROUND: Multi-institutional collaborations provide granularity lacking in epidemiologic datasets to enable in-depth study of rare diseases. For pts with superficial, high-grade soft tissue sarcomas (STS) of the trunk/extremity, the value of radiation therapy (RT) is not clear. We aimed to utilize the 7-institution US-Sarcoma-Collaborative (USSC) and the National Cancer Database (NCDB) to investigate this issue. STUDY DESIGN: All adult pts with superficial truncal/extremity high-grade STS who underwent primary curative-intent resection from 2000-2016 at USSC institutions or were included in the NCDB from 2004-2013 were analyzed...
June 12, 2018: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/29904744/superior-metastasis-free-survival-for-patients-with-high-risk-prostate-cancer-treated-with-definitive-radiation-therapy-compared-to-radical-prostatectomy-a-propensity-score-matched-analysis
#12
Stephanie Markovina, Marshall W Meeks, Shahed Badiyan, Joel Vetter, Hiram A Gay, Alethea Paradis, Jeff Michalski, Gurdarshan Sandhu
Purpose: For high-risk prostate cancer (HR-PCa) in men with a life expectancy of at least 10 years, the National Comprehensive Cancer Network recommends radiation therapy (RT) plus androgen deprivation therapy (ADT) with category 1 evidence or radical prostatectomy (RP) as an acceptable initial therapy. Randomized evidence regarding which therapy is optimal for disease control is lacking for men with HR-PCa. We performed a propensity-score-matched comparison of outcomes for men with localized HR-PCa treated with primary RT or RP...
April 2018: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/29903519/transcatheter-or-surgical-treatment-of-severe-aortic-stenosis-and-coronary-artery-disease-a-comparative-analysis-from-the-italian-observant-study
#13
Marco Barbanti, Sergio Buccheri, Davide Capodanno, Paola D'Errigo, Marco Ranucci, Stefano Rosato, Gennaro Santoro, Danilo Fusco, Corrado Tamburino, Fausto Biancari, Fulvia Seccareccia
BACKGROUND: To assess clinical outcomes of patients with concomitant severe aortic stenosis (AS) and coronary artery disease (CAD) who underwent transcatheter aortic valve implantation (TAVI) and percutaneous coronary intervention (PCI) or surgical aortic valve replacement (SAVR) and coronary artery bypass grafting (CABG). METHODS: Data were extracted from the multicenter OBSERVANT study. For the purposes of the present analysis, we included only patients with established stable CAD meeting any of the following inclusion criteria: 1) TAVI patients with CAD undergoing staged PCI or TAVI and PCI in the same session; 2) SAVR patients undergoing combined SAVR and CABG in the same session...
June 7, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29903295/-comparisons-of-the-influence-of-raising-people-s-identity-on-mental-health-between-two-parents-family-children-and-single-parent-family-children-by-propensity-score-matching
#14
Daoyang Wang, Shuting Li, Mingming Hu
OBJECTIVE: To compare the difference of mental health( anxiety, depression, loneliness, self-esteem, self-confidence, family life satisfaction) and the role of raising people's identity in happiness relationship between two-parents family children and single parent family children by propensity score matching( PSM). METHODS: Datafrom Social Adaptation Database of National Children 's Study of China. Stratified and population-based cluster random sampling method was used to sample, a total of 23 499 subjects were 6-15 year-old children coming from 31 provinces of 100 districts and counties in mainland China...
September 2017: Wei Sheng Yan Jiu, Journal of Hygiene Research
https://www.readbyqxmd.com/read/29902981/anaerobic-coverage-as-definitive-therapy-does-not-affect-clinical-outcomes-in-community-onset-bacteremic-biliary-tract-infection-without-anaerobic-bacteremia
#15
Pei-Shan Wu, Chien Chuang, Ping-Feng Wu, Yi-Tsung Lin, Fu-Der Wang
BACKGROUND: Antibiotics with anaerobic coverage are widely used for the treatment of biliary tract infection (BTI), even in the absence of isolated anaerobes. The current study aimed to investigate the differences in clinical outcomes in patients with community-onset bacteremic BTIs without anaerobic bacteremia, treated with vs. without anti-anaerobic coverage. METHODS: A retrospective analysis was conducted at a medical center in Taiwan from September 2014 to March 2016...
June 15, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29902975/outlier-classification-performance-of-risk-adjustment-methods-when-profiling-multiple-providers
#16
Timo B Brakenhoff, Kit C B Roes, Karel G M Moons, Rolf H H Groenwold
BACKGROUND: When profiling multiple health care providers, adjustment for case-mix is essential to accurately classify the quality of providers. Unfortunately, misclassification of provider performance is not uncommon and can have grave implications. Propensity score (PS) methods have been proposed as viable alternatives to conventional multivariable regression. The objective was to assess the outlier classification performance of risk adjustment methods when profiling multiple providers...
June 15, 2018: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/29902266/statins-increase-the-risk-of-herpes-zoster-a-propensity-score-matched-analysis
#17
Min-Chul Kim, Sung-Cheol Yun, Sang-Oh Lee, Sang-Ho Choi, Yang Soo Kim, Jun Hee Woo, Sung-Han Kim
OBJECTIVES: Statins, which are lipid-lowering agents, have anti-inflammatory and immunomodulatory properties that may affect the occurrence of various infectious diseases. We assessed whether statins increase the risk of herpes zoster (HZ) with propensity score-matching. METHODS: The study was based on the National Health Insurance database and its subset database of the "medical check-up" population of South Korea. These cohorts consist of about one million and 570,000 people, respectively, representative of the entire population of South Korea...
2018: PloS One
https://www.readbyqxmd.com/read/29902236/short-and-long-term-survival-after-open-versus-endovascular-repair-of-abdominal-aortic-aneurysm-polish-population-analysis
#18
Bartosz Symonides, Andrzej Śliwczyński, Zbigniew Gałązka, Jarosław Pinkas, Zbigniew Gaciong
OBJECTIVES: The aim of the study was to compare short and long-term mortality and readmissions in patients with non-ruptured abdominal aortic aneurysm (AAA) treated with endovascular aortic repair (EVAR) or open aneurysm repair (OAR). DESIGN: Retrospective survival analysis based on prospectively collected medical records of the national Polish public health insurer. MATERIALS: In the National Health Fund database we identified all patients who underwent elective open or endovascular treatment of AAA between January 1st 2011 and March 22nd 2016...
2018: PloS One
https://www.readbyqxmd.com/read/29901622/impact-of-nucleos-t-ide-analog-treatment-on-the-development-of-malignancy-in-patients-with-chronic-hepatitis-b
#19
Soon Sun Kim, Eun Kyoung Ahn, Soo Yeon Cho, Rae Woong Park, Hyo Jung Cho, Ji-Hyun Kim, Han Gyeol Kim, Ga Ram Lee, Sun Hyuk Hwang, Min Jae Yang, Jae Youn Cheong, Sung Won Cho
We evaluated whether nucleos(t)ide analog (NA) influences the risk of non-hepatocellular carcinoma (non-HCC) malignancies in patients with chronic hepatitis B (CHB). A total of 9867 patients with CHB were followed up for ≥12 months for the occurrence of any type of malignancy between 1998 and 2013. Patients who received NA for ≥180 days were defined as the NA group. Propensity score matching produced the control (n = 2220) and NA groups (n = 2220) after adjustment for age, sex, and the presence of diabetes mellitus and liver cirrhosis...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29901539/prevalence-and-natural-course-of-transverse-ligament-of-the-atlas-calcification-in-asymptomatic-healthy-individuals
#20
Masato Anno, Yasushi Oshima, Yuki Taniguchi, Yoshitaka Matsubayashi, So Kato, Kazuhito Soma, Hiroyuki Oka, Naoto Hayashi, Sakae Tanaka
STUDY DESIGN: A retrospective cross-sectional study. OBJECTIVE: To assess the prevalence and natural course of calcification of the transverse ligament of the atlas (TLA) in healthy subjects and to investigate the relationship between the calcified lesion and clinical factors. SUMMARY OF BACKGROUND DATA: The prevalence and etiology of TLA calcification in healthy individuals remain uncertain. METHODS: We enrolled 1136 participants undergoing computed tomography (CT) scans in their routine medical checkups...
June 12, 2018: Spine
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