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https://www.readbyqxmd.com/read/29652869/effect-of-sustained-hypoxia-on-autophagy-of-genioglossus-muscle-derived-stem-cells
#1
Dongsheng Zhang, Shanshan Jia, Hengkun Wang, Shengyun Huang, Lili Xiao, Li Ma, Guangping Liu, Kun Gong, Le Xu
BACKGROUND Previous studies have demonstrated that sustained hypoxia in people with obstructive sleep apnea (OSA) impairs upper airway muscle activity, but the underlying mechanism remains poorly understood. As autophagy acts as an important regulator under hypoxia stress, we performed an in vitro investigation of the effects of sustained hypoxia on autophagy of genioglossus muscle-derived stem cells (GG MDSC), an important component of the upper airway muscle. MATERIAL AND METHODS Genioglossus MDSCs were obtained from Sprague-Dawley (SD) rats and identified by using immunofluorescence staining for CD34, Sca-1, and desmin...
April 13, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29607167/protective-effects-of-pi3kcg-gene-on-acute-myocardial-infarction
#2
Ge Gong, Xin-Xing Yang, Yan-Yan Li, Hong-Yu Geng, Hui Wang, Lian-Sheng Wang, Zhi-Jian Yang
Background: To study the protective effects of recombinant phosphatidylinositol 3-kinase p110 gamma ( rPLV-PI3KCG ) lentiviral vector in Sprague-Dawley (SD) rats with acute myocardial infarction (AMI). Method: The AMI rat models were established by ligaturing left anterior descending coronary artery. The rPLV-PI3KCG or empty lentiviral vectors were injected at the edge of the infarct zone. The experiment was divided randomly into four groups (n=8): (I) Sham group; (II) AMI group; (III) AMI + empty vector injection group (AMI + E group); and (IV) AMI + PLV-PI3KCG injection group (AMI + PLV-PI3KCG group)...
February 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29597186/levels-of-endocan-angiopoietin-2-and-hypoxia-inducible-factor-1a-in-patients-with-autosomal-dominant-polycystic-kidney-disease-and-different-levels-of-renal-function
#3
Vassilios Raptis, Constantinos Bakogiannis, Charalampos Loutradis, Afroditi K Boutou, Ioanna Lampropoulou, Elena Intzevidou, Athanasios Sioulis, Elias Balaskas, Pantelis A Sarafidis
BACKGROUND: Endothelial dysfunction leading to unbalanced vasoconstriction and ischemia of renal parenchyma is increasingly proposed as an alternative pathway of renal damage in autosomal dominant polycystic kidney disease (ADPKD). However, human studies investigating the evolution of such phenomena are limited. This study investigated the levels of emerging biomarkers of endothelial function, angiogenesis and hypoxia, in ADPKD patients with different renal function. METHODS: The study population consisted of three groups: 26 ADPKD patients with impaired renal function (Group A; estimated glomerular filtration rate [eGFR] 45-70 mL/min/1...
March 29, 2018: American Journal of Nephrology
https://www.readbyqxmd.com/read/29519653/controlled-cell-morphology-and-liver-specific-function-of-engineered-primary-hepatocytes-by-fibroblast-layer-cell-densities
#4
Yusuke Sakai, Makiko Koike, Daisuke Kawahara, Hideko Hasegawa, Tomomi Murai, Kosho Yamanouchi, Akihiko Soyama, Masaaki Hidaka, Mitsuhisa Takatsuki, Fumihiko Fujita, Tamotsu Kuroki, Susumu Eguchi
Engineered primary hepatocytes, including co-cultured hepatocyte sheets, are an attractive to basic scientific and clinical researchers because they maintain liver-specific functions, have reconstructed cell polarity, and have high transplantation efficiency. However, co-culture conditions regarding engineered primary hepatocytes were suboptimal in promoting these advantages. Here we report that the hepatocyte morphology and liver-specific function levels are controlled by the normal human diploid fibroblast (TIG-118 cell) layer cell density...
March 5, 2018: Journal of Bioscience and Bioengineering
https://www.readbyqxmd.com/read/29491093/an-exploratory-study-of-radiation-dermatitis-in-breast-cancer-patients
#5
Eleftheria Alexopoulou, Theodora Katsila, Maria Tolia, Nikolaos Tsoukalas, Michael Leontsinidis, George Kyrgias, Vasilios Kouloulias, George P Patrinos, Despoina Spyropoulou, Dimitrios Kardamakis
BACKGROUND/AIM: Radiation dermatitis is observed in 95% of breast cancer patients receiving radiotherapy. The aim of this study was to explore the correlation between protein expression in tumor cells and the risk of developing radiation dermatitis. PATIENTS AND METHODS: Breast cancer patients receiving postoperative radiotherapy were included in this study. Tumor specimens from 122 patients were examined by immunohistochemistry for the expression of Ki67, ataxia telangiectasia mutated (ATM) kinase, hypoxia-inducible factor-1-alpha (HIF-1a), inducible nitric oxide synthase (iNOS), and a-glucosidase (aGluc)...
March 2018: Anticancer Research
https://www.readbyqxmd.com/read/29436491/long-non-coding-rna-linc00657-acting-as-mir-590-3p-sponge-to-facilitate-low-concentration-oxidized-low-density-lipoprotein-induced-angiogenesis
#6
Mei-Hua Bao, Guang-Yi Li, Xiao-Shan Huang, Liang Tang, Li-Ping Dong, Jian-Ming Li
Angiogenesis in atherosclerotic plaque promotes plaque growth, causes plaque hemorrhage and violates plaque stability. LINC00657 is a long noncoding RNA highly conserved and abundantly expressed in vascular endothelial cells. The present study was designed to investigate the effects and mechanisms of LINC00675 on the low concentration of oxidized low-density lipoprotein (oxLDL) induced angiogenesis. Cell proliferation assay, transwell assay, wound healing assay, and tube formation assay were conducted to detect the effects of low concentration of oxLDL on angiogenesis; The results discovered that oxLDL promoted the cell proliferation, migration, and tube formation...
February 7, 2018: Molecular Pharmacology
https://www.readbyqxmd.com/read/29425795/postconditioning-with-repeated-mild-hypoxia-protects-neonatal-hypoxia-ischemic-rats-against-brain-damage-and-promotes-rehabilitation-of-brain-function
#7
Yanqun Chang, Qingqing Deng, Xiaomao Cheng, Xingang Luo, Jing Zhang, Xiaoyuan Tang
RATIONALE: Mild hypoxia conditioning induced by repeated episodes of transient ischemia is a clinically applicable method for protecting the brain against injury after hypoxia-ischemic brain damage. OBJECTIVE: To assess the effect of repeated mild hypoxia postconditioning on brain damage and long-term neural functional recovery after hypoxia-ischemic brain damage. METHODS: and Results Rats received different protocols of repeated mild hypoxia postconditioning...
February 6, 2018: Brain Research Bulletin
https://www.readbyqxmd.com/read/29411043/hif-1a-gene-polymorphisms-and-its-protein-level-in-patients-with-rheumatoid-arthritis-a-case-control-study
#8
Agnieszka Paradowska-Gorycka, Barbara Stypinska, Andrzej Pawlik, Ewa Haladyj, Katarzyna Romanowska-Próchnicka, Marzena Olesinska
OBJECTIVES: The aim of the study was to identify HIF-1A genetic variants and their possible association with HIF-1α, VEGF, KDR, RORc and Foxp3 protein levels, and susceptibility to and severity of RA. METHODS: The HIF-1A gene polymorphisms were genotyped for 587 RA patients and 341 healthy individuals. The HIF-1α, VEGF, KDR, RORc and Foxp3serum levels were evaluated. RESULTS: Under the codominant model, the frequency of the rs12434438 GG genotype was lower in RA patients than in controls (P = 0...
February 6, 2018: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/29383777/lncrna-bc005927-upregulates-ephb4-and-promotes-gastric-cancer-metastasis-under-hypoxia
#9
Xiangqiang Liu, Yafang Wang, Li Sun, Jie Min, Jiaming Liu, Di Chen, Hongbo Zhang, Hongwei Zhang, Helong Zhang, Yongan Zhou, Lili Liu
Hypoxia plays a critical role in the metastasis of gastric cancer (GC), yet the underlying mechanism remains largely unclear. It is also not known if lncRNAs are involved in the contribution of hypoxia to the GC metastasis. In this study, we found that lncRNA BC005927 can be induced by hypoxia in GC cells and mediates hypoxia-induced GC cell metastasis. Furthermore, BC005927 is frequently up-regulated in GC samples and increased BC005927 expression was correlated with a higher tumor-node-metastasis stage. GC patients with higher BC005927 expression had poorer prognoses than those with lower expression...
January 30, 2018: Cancer Science
https://www.readbyqxmd.com/read/29371983/augmentation-of-hypoxia-inducible-factor-1-alpha-in-reinfused-blood-cells-enhances-diabetic-ischemic-wound-closure-in-mice
#10
Huan Wang, Yufeng Feng, Xiaoju Jin, Rong Xia, Yong Cheng, Xiaoqian Liu, Nana Zhu, Xun Zhou, Lei Yin, Jianrong Guo
Diabetes-associated dysfunction in angiogenesis predominantly contributes to impairment of wound closure, but a role of hypoxia-inducible factor 1 alpha (HIF-1a) in the process remain poorly understood. Here, we examined whether expression of HIF-1a in re-infused blood cells may improve the diabetic wound closure in mice. We found that that expression of HIF-1a in re-infused isogeneic blood cells significantly improved diabetic wound healing in mice, seemingly through augmentation of wound-associated angiogenesis...
December 26, 2017: Oncotarget
https://www.readbyqxmd.com/read/29365454/hif-1a-promotes-necroptosis-in-macrophages-by-micrornas
#11
Ela Karshovska, Andreas Schober
No abstract text is available yet for this article.
August 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29362130/influence-of-tumor-and-microenvironment-characteristics-on-diffusion-weighted-imaging-in-oropharyngeal-carcinoma-a-pilot-study
#12
Justin E Swartz, Juliette P Driessen, Pauline M W van Kempen, Remco de Bree, Luuk M Janssen, Frank A Pameijer, Chris H J Terhaard, Marielle E P Philippens, Stefan Willems
OBJECTIVES: Diffusion weighted imaging (DWI) is a frequently performed MRI sequence in cancer patients. While previous studies have shown the clinical value of the apparent diffusion coefficient (ADC) for response prediction and response monitoring, less is known about the biological background of ADC. In the tumor microenvironment, hypoxia and increased proliferation of tumor cells contribute to resistance to (radio-)therapy, while high T-cell influx is related to better prognosis. We investigated the correlation between these three tissue characteristics and ADC in 20 oropharyngeal squamous cell carcinoma patients...
February 2018: Oral Oncology
https://www.readbyqxmd.com/read/29276042/intestinal-tight-junctions-are-severely-altered-in-nec-preterm-neonates
#13
Amir Bein, Smadar Eventov-Friedman, Dan Arbell, Betty Schwartz
BACKGROUND & AIMS: Necrotizing Enterocolitis (NEC) is a severe inflammatory disorder of the intestine endangering the health and survival of preterm infants. It is well established that the gut barrier is severely damaged in NEC patients, nonetheless an in depth investigation of modifications at the transcriptional and translational levels of tight junction genes and proteins during NEC are still missing. The aim of this study was to investigate changes in the expression of tight junctions and other associated proteins during NEC and determine their correlation to the disease severity...
December 7, 2017: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/29236166/correction-to-expression-of-matrix-metalloproteinase-12-is-highly-specific-for-non-proliferating-invasive-trophoblasts-in-the-first-trimester-and-temporally-regulated-by-oxygen-dependent-mechanisms-including-hif-1a
#14
Ursula Hiden, Christian P Eyth, Alejandro Majali-Martinez, Gernot Desoye, Carmen Tam-Amersdorfer, Berthold Huppertz, Nassim Ghaffari Tabrizi-Wizsy
In the original publication, the contribution of Dr. Christian Eyth as equal first author was not indicated. This has been corrected confirming that U. Hidden and C. Eyth contributed equally to this work.
January 2018: Histochemistry and Cell Biology
https://www.readbyqxmd.com/read/29228704/role-of-hif-1a-in-regulating-autophagic-cell-survival-during-cerebral-ischemia-reperfusion-in-rats
#15
Yongqing Guo
Hypoxia-inducible factor-1a (HIF-1a) plays a beneficial role during cerebral ischemia reperfusion (IR), but the underlying molecular mechanisms are not completely understood. Here, we aimed to investigate the effects and molecular regulation of HIF-1a on brain cell apoptosis and autophagy during IR. We found that augmentation of HIF-1a in re-perfused hematopoietic cells significantly reduced brain damage, alleviated brain edema and improved neural function during IR, seemingly through two HIF-1a target genes BNIP3 and NIX, which were critical regulators for cell apoptosis and autophagic cell survival...
November 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29206859/proteus-mirabilis-inhibits-cancer-growth-and-pulmonary-metastasis-in-a-mouse-breast-cancer-model
#16
Hong Zhang, Hongxiu Diao, Lixin Jia, Yujing Yuan, Douglas H Thamm, Huanan Wang, Yipeng Jin, Shimin Pei, Bin Zhou, Fang Yu, Linna Zhao, Nan Cheng, Hongchao Du, Ying Huang, Di Zhang, Degui Lin
A variety of bacteria have been used as agents and vectors for antineoplastic therapy. A series of mechanisms, including native bacterial toxicity, sensitization of the immune system and competition for nutrients, may contribute to antitumor effects. However, the antitumor effects of Proteus species have been minimally studied, and it is not clear if bacteria can alter tumor hypoxia as a component of their antineoplastic effect. In the present study, Proteus mirabilis bacteria were evaluated for the ability to proliferate and accumulate in murine tumors after intravenous injection...
2017: PloS One
https://www.readbyqxmd.com/read/29148169/antitumor-and-anti-metastatic-mechanisms-of-rhizoma-paridis-saponins-in-lewis-mice
#17
Shuli Man, Hongyan Chai, Jingxia Cui, Jingwen Yao, Long Ma, Wenyuan Gao
Lung cancer is one of the most common causes of death in the world. Rhizoma paridis saponins (RPS) have been found to show inhibition of pulmonary adenoma in previous research. However, the detailed mechanisms of RPS from a holistic view have not been established. In this study, Lewis pulmonary adenoma mice were successfully established to analyze the pathways involved in RPS intervening tumor formation and progression. As a result, RPS inhibited levels of cytokines or receptors such as VEGFD, VEGFR3, RAGE, IL6R, IL17BR, and CXCL16 which were regarded as the initiators induced tumor cell proliferation, adhesion, angiogenesis, and invasion...
February 2018: Environmental Toxicology
https://www.readbyqxmd.com/read/29147618/programmed-cell-death-ligands-expression-in-phaeochromocytomas-and-paragangliomas-relationship-with-the-hypoxic-response-immune-evasion-and-malignant-behavior
#18
David J Pinato, James R Black, Sebastian Trousil, Roberto E Dina, Pritesh Trivedi, Francesco A Mauri, Rohini Sharma
The hypoxic response underlies the pathogenesis and malignant behavior of PCC/PGL. Regulation of PD-1 receptor-ligand signaling, a therapeutically actionable driver of the anti-tumor immune response, is a hypoxic-driven trait across malignancies. We evaluated the prognostic role of PD ligands in association with biomarkers of hypoxia and angiogenesis in patients with PCC/PGL. Tissue microarrays sections including consecutive cases diagnosed between 1983-2011 were stained for PD-L1 and 2, hypoxia inducible factor 1a (Hif-1a), Carbonic Anhydrase IX (CaIX), Vascular Endothelial Growth Factor-A (VEGF-A)...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/29108271/hypoxia-related-biological-markers-as-predictors-of-epirubicin-based-treatment-responsiveness-and-resistance-in-locally-advanced-breast-cancer
#19
Manuela Milani, Sergio Venturini, Simone Bonardi, Giovanni Allevi, Carla Strina, Maria Rosa Cappelletti, Silvia Paola Corona, Sergio Aguggini, Alberto Bottini, Alfredo Berruti, Adrian Jubb, Leticia Campo, Adrian L Harris, Kevin Gatter, Stephen B Fox, Daniele Generali, Giandomenico Roviello
Purpose: To identify hypoxia-related biomarkers indicative of response and resistance to epirubicin treatment in patients with locally advanced breast cancer. Patients and Methods: One hundred seventy-six women with T2-4 N0-1 breast tumours were randomly assigned to receive epirubicin 120 mg/m2/1-21 (EPI ARM), epirubicin 120 mg/m2/1-21 + erythropoietin 10.000 IU sc three times weekly (EPI-EPO ARM) and epirubicin 40 mg/m2/w-q21 (EPI-W ARM). Sixteen tumour proteins involved in cell survival, hypoxia, angiogenesis and growth factor, were assessed by immunohistochemistry in pre-treatment samples...
October 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29069822/alpha-lipoic-acid-attenuates-radiation-induced-oral-mucositis-in-rats
#20
Jin Hyun Kim, Myeong Hee Jung, Jin Pyeong Kim, Hyun-Jung Kim, Jung Hwa Jung, Jong Ryeal Hahm, Ki Mun Kang, Bae-Kwon Jeong, Seung Hoon Woo
PURPOSE: Radiotherapy is currently one of the main treatment modalities for head and neck cancer; however, it also results in severe toxicity to the normal tissue, to the detriment of patients. This study aimed to investigate whether alpha lipoic acid (ALA) could protect against radiation-induced oral mucositis in a rat model. RESULTS: On post-irradiation days 4 and 7, the epithelial layer on oral mucosa showed pronounced injury (shortening of the layer) and it is diminished by ALA pretreatment before radiation...
September 22, 2017: Oncotarget
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