Jiaqi Huang, Qianqian Yin, Yuqing Wang, Xin Zhou, Yunyun Guo, Yuanjun Tang, Rui Cheng, Xiaotong Yu, Jie Zhang, Chen Huang, Zhanya Huang, Jianlin Zhang, Zhengyang Guo, Xiao Huo, Yan Sun, Yanfang Li, Hao Wang, Jianling Yang, Lixiang Xue
The regulation of PD-L1 is the key question, which largely determines the outcome of the immune checkpoint inhibitors (ICIs) based therapy. However, besides the transcription level, the protein stability of PD-L1 is closely correlated with its function and has drawn increasing attention. In this study, EZH2 inhibition enhances PD-L1 expression and protein stability, and the deubiquitinase ubiquitin-specific peptidase 22 (USP22) is identified as a key mediator in this process. EZH2 inhibition transcriptionally upregulates USP22 expression, and upregulated USP22 further stabilizes PD-L1...
March 22, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)