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https://www.readbyqxmd.com/read/29782332/detection-of-high-risk-thrombophilia-with-an-automated-global-test-the-coagulation-inhibitor-potential-assay
#1
Barbara Réger, Hajna Losonczy, Ágnes Nagy, Ágnes Péterfalvi, Réka Mózes, László Pótó, Nelli Farkas, Gábor L Kovács, Attila Miseta, Alizadeh Hussain, Orsolya Tóth
: The diagnosis of thrombophilia is a cost-consuming and time-consuming process, as each defect should be separately investigated. The Coagulation Inhibitor Potential (CIP) assay is a promising new global test, sensitive for most of the hereditary thrombophilias, developed for manual methodology. We adapt the original method to an optical coagulation analyser. By this automation, the test will be easier, faster and more precise, and it also allows carrying out 18 measurements simultaneously. The CIP assay was performed in 126 healthy subjects and 193 patients with different types of hereditary thrombophilia conditions...
May 17, 2018: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://www.readbyqxmd.com/read/29739343/gender-difference-in-the-effects-of-interleukin-6-on-grip-strength-a-systematic-review-and-meta-analysis
#2
Alexandra Mikó, László Pótó, Péter Mátrai, Péter Hegyi, Nóra Füredi, András Garami, Anita Illés, Margit Solymár, Áron Vincze, Márta Balaskó, Gabriella Pár, Patrícia Sarlós, Judit Bajor, Judit Tenk, Ildikó Rostás, Erika Pétervári
BACKGROUND: Aging sarcopenia characterized by low muscle mass with low muscle strength affects men and women differently. The contribution of interleukin-6 (IL-6) to sarcopenia has been suggested based on a negative correlation between plasma IL-6 and muscle function described by some studies. However, no consensus regarding clinically relevant cut-off criteria has been reached. Another question arises whether pooling male and female data is an accurate way to determine the predictive value of IL-6 in sarcopenia...
May 8, 2018: BMC Geriatrics
https://www.readbyqxmd.com/read/29694269/larva-migrans-of-baylisascaris-potosis-in-experimental-animals
#3
Kensuke Taira, Shohei Nakamura, Toshihiro Tokiwa, Yumi Une
Occurrence of clinical signs by infection with Baylisascaris potosis, the roundworm of kinkajous (Potos flavus), in mice, rats and rabbit were studied, and the migration behavior of larvae in mice were compared with that of B. transfuga the round worm of bears (Ursus spp.). Three groups of 8 mice, 3 groups of 6 rats and 3 groups of 2 rabbits were inoculated with either 10, 100 or 1,000 B. potosis eggs. The other 8 mice were inoculated with 1,000 B. transfuga eggs. Animals were monitored for occurrence of clinical signs until 60 days post-inoculation (DPI)...
April 25, 2018: Journal of Parasitology
https://www.readbyqxmd.com/read/29681213/therapeutic-whole-body-hypothermia-reduces-mortality-in-severe-traumatic-brain-injury-if-the-cooling-index-is-sufficiently-high-meta-analyses-of-the-effect-of-single-cooling-parameters-and-their-integrated-measure
#4
Emoke Olah, Laszlo Poto, Peter Hegyi, Imre Szabo, Petra Hartmann, Margit Solymar, Erika Petervari, Marta Balasko, Tamas Habon, Zoltan Rumbus, Judit Tenk, Ildiko Rostas, Jordan Weinberg, Andrej A Romanovsky, Andras Garami
Therapeutic hypothermia was investigated repeatedly as a tool to improve the outcome of severe traumatic brain injury (TBI), but previous clinical trials and meta-analyses found contradictory results. We aimed to determine the effectiveness of therapeutic whole-body hypothermia on the mortality of adult patients with severe TBI by using a novel approach of meta-analysis. We searched the PubMed, EMBASE, and Cochrane Library databases from inception to February 2017. The identified human studies were evaluated regarding statistical, clinical, and methodological designs to ensure inter-study homogeneity...
April 21, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29660910/pneumoperitoneum-induced-ischemia-reperfusion-injury-of-the-peritoneum-preconditioning-may-reduce-the-negative-side-effects-caused-by-carbon-dioxide-pneumoperitoneum-pilot-study
#5
Tünde Gyöngyvér Veres, Ildikó Takács, Tibor Nagy, Gábor Jancsó, Ariella Kondor, László Pótó, András Vereczkei
INTRODUCTION: Laparoscopy is more beneficial than the conventional open technique, however the pneumoperitoneum created may have an ischemic side effect. OBJECTIVE: Our aim was to evaluate the protective effects of preconditioning during laparoscopic cholecystectomies (LC). METHODS: 30 patients were randomized into 2 groups: I. PreC (preconditioning: 5 min. inflation, 5 min. deflation, followed by conventional LC), II: LC (conventional LC)...
April 13, 2018: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/29538406/identification-of-race-associated-metabolite-biomarkers-for-hepatocellular-carcinoma-in-patients-with-liver-cirrhosis-and-hepatitis-c-virus-infection
#6
Cristina Di Poto, Shisi He, Rency S Varghese, Yi Zhao, Alessia Ferrarini, Shan Su, Abdullah Karabala, Mesfin Redi, Hassen Mamo, Amol S Rangnekar, Thomas M Fishbein, Alexander H Kroemer, Mahlet G Tadesse, Rabindra Roy, Zaki A Sherif, Deepak Kumar, Habtom W Ressom
Disparities in hepatocellular carcinoma (HCC) incidence and survival have been observed between ethnic groups including African-Americans (AA) and European-Americans (EA). The evaluation of the changes in the levels of metabolites in samples stratified by race could provide a snapshot of ethnically diverse disease related pathways and identify reliable biomarkers. In this study, we considered AA and EA to investigate metabolites that may be associated with HCC in a race-specific manner. The levels of 46 metabolites in plasma samples, collected from patients recruited at MedStar Georgetown University Hospital, were analyzed by Agilent GC-qMS in selected ion monitoring (SIM) mode...
2018: PloS One
https://www.readbyqxmd.com/read/29441707/the-influence-of-diet-on-masticatory-motor-patterns-in-musteloid-carnivorans-an-analysis-of-jaw-adductor-activity-in-ferrets-mustela-putorius-furo-and-kinkajous-potos-flavus
#7
Jillian S Davis, Susan H Williams
Broad similarities in the timing of jaw adductor activity driving jaw movements across distantly related and morphologically disparate species have led to the hypothesis that mammalian masticatory motor patterns are conserved. However, some quantitative analyses also suggest that masticatory motor patterns have evolved in concert with dietary and/or morphological specialization. Here, we assess this relationship in two closely related carnivoran species with divergent diets and morphology: carnivorous ferrets and frugivorous kinkajous...
November 2017: Journal of Experimental Zoology. Part A, Ecological and Integrative Physiology
https://www.readbyqxmd.com/read/28809927/in-middle-aged-and-old-obese-patients-training-intervention-reduces-leptin-level-a-meta-analysis
#8
REVIEW
Ildikó Rostás, László Pótó, Péter Mátrai, Péter Hegyi, Judit Tenk, András Garami, Anita Illés, Margit Solymár, Erika Pétervári, Ákos Szűcs, Andrea Párniczky, Dániel Pécsi, Zoltán Rumbus, Csaba Zsiborás, Nóra Füredi, Márta Balaskó
BACKGROUND: Leptin is one of the major adipokines in obesity that indicates the severity of fat accumulation. It is also an important etiological factor of consequent cardiometabolic and autoimmune disorders. Aging has been demonstrated to aggravate obesity and to induce leptin resistance and hyperleptinemia. Hyperleptinemia, on the other hand, may promote the development of age-related abnormalities. While major weight loss has been demonstrated to ameliorate hyperleptinemia, obese people show a poor tendency to achieve lasting success in this field...
2017: PloS One
https://www.readbyqxmd.com/read/28433148/mechanics-and-transport-phenomena-in-agarose-based-hydrogels-studied-by-compression-relaxation-tests
#9
Diego Caccavo, Sara Cascone, Serena Poto, Gaetano Lamberti, Anna Angela Barba
Hydrogels are widespread materials, used in several frontier fields, due to their peculiar behavior: they couple solvent mass transport to system mechanics, exhibiting viscoelastic and poroelastic characteristics. The full understanding of this behavior is crucial to correctly design such complex systems. In this study agarose gels has been investigated through experimental stress-relaxation tests and with the aid of a 3D poroviscoelastic model. At the investigated experimental conditions, the agarose gels samples show a prevalent viscoelastic behavior, revealing limited water transport and an increase of the stiffness as well as of the relaxation time along with the polymer concentration...
July 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28283029/legal-immigrants-invasion-of-alien-microbial-communities-during-winter-occurring-desert-dust-storms
#10
Tobias Weil, Carlotta De Filippo, Davide Albanese, Claudio Donati, Massimo Pindo, Lorenzo Pavarini, Federico Carotenuto, Massimiliano Pasqui, Luisa Poto, Jacopo Gabrieli, Carlo Barbante, Birgit Sattler, Duccio Cavalieri, Franco Miglietta
BACKGROUND: A critical aspect regarding the global dispersion of pathogenic microorganisms is associated with atmospheric movement of soil particles. Especially, desert dust storms can transport alien microorganisms over continental scales and can deposit them in sensitive sink habitats. In winter 2014, the largest ever recorded Saharan dust event in Italy was efficiently deposited on the Dolomite Alps and was sealed between dust-free snow. This provided us the unique opportunity to overcome difficulties in separating dust associated from "domestic" microbes and thus, to determine with high precision microorganisms transported exclusively by desert dust...
March 10, 2017: Microbiome
https://www.readbyqxmd.com/read/28269041/multi-omic-approaches-for-characterization-of-hepatocellular-carcinoma
#11
Habtom W Ressom, Cristina Di Poto, Alessia Ferrarini, Yunli Hu, Mohammad R Nezami Ranjbar, Ehwang Song, Rency S Varghese, Minkun Wang, Shiyue Zhou, Rui Zhu, Yiming Zuo, Mahlet G Tadesse, Yehia Mechref
Multi-omic approaches offer the opportunity to characterize complex diseases such as cancer at various molecular levels. In this paper, we present transcriptomic, proteomic/glycoproteomic, glycomic, and metabolomic (TPGM) data we acquired by analysis of liver tissues from hepatocellular carcinoma (HCC) cases and patients with liver cirrhosis. We evaluated changes in the levels of transcripts, proteins, glycans, and metabolites between tumor and cirrhotic tissues by statistical methods. We demonstrated the potential of multi-omic approaches and network analysis to investigate the interactions among these biomolecules in the progression of liver cirrhosis to HCC...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227255/multi-omic-approaches-for-characterization-of-hepatocellular-carcinoma
#12
Habtom W Ressom, Cristina Di Poto, Alessia Ferrarini, Yunli Hu, Mohammad R Nezami Ranjbar, Ehwang Song, Rency S Varghese, Minkun Wang, Shiyue Zhou, Rui Zhu, Yiming Zuo, Mahlet G Tadesse, Yehia Mechref, Habtom W Ressom, Cristina Di Poto, Alessia Ferrarini, Yunli Hu, Mohammad R Nezami Ranjbar, Ehwang Song, Rency S Varghese, Minkun Wang, Shiyue Zhou, Rui Zhu, Yiming Zuo, Mahlet G Tadesse, Yehia Mechref, Mahlet G Tadesse, Shiyue ZhOU, Rui Zhu, Yehia Mechref, Alessia Ferrarini, Cristina Di Poto, Yiming Zuo, Habtom W Ressom, Mohammad R Nezami Ranjbar, Ehwang Song, Minkun Wang, Rency S Varghese, Yunli Hu
Multi-omic approaches offer the opportunity to characterize complex diseases such as cancer at various molecular levels. In this paper, we present transcriptomic, proteomic/glycoproteomic, glycomic, and metabolomic (TPGM) data we acquired by analysis of liver tissues from hepatocellular carcinoma (HCC) cases and patients with liver cirrhosis. We evaluated changes in the levels of transcripts, proteins, glycans, and metabolites between tumor and cirrhotic tissues by statistical methods. We demonstrated the potential of multi-omic approaches and network analysis to investigate the interactions among these biomolecules in the progression of liver cirrhosis to HCC...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/27913395/metabolomic-characterization-of-hepatocellular-carcinoma-in-patients-with-liver-cirrhosis-for-biomarker-discovery
#13
Cristina Di Poto, Alessia Ferrarini, Yi Zhao, Rency S Varghese, Chao Tu, Yiming Zuo, Minkun Wang, Mohammad R Nezami Ranjbar, Yue Luo, Chi Zhang, Chirag S Desai, Kirti Shetty, Mahlet G Tadesse, Habtom W Ressom
Background: Metabolomics plays an important role in providing insight into the etiology and mechanisms of hepatocellular carcinoma (HCC). This is accomplished by a comprehensive analysis of patterns involved in metabolic alterations in human specimens. This study compares the levels of plasma metabolites in HCC cases versus cirrhotic patients and evaluates the ability of candidate metabolites in distinguishing the two groups. Also, it investigates the combined use of metabolites and clinical covariates for detection of HCC in patients with liver cirrhosis...
May 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/27870946/conserved-hierarchical-gain-of-chromosome-4-is-an-independent-prognostic-factor-in-high-hyperdiploid-pediatric-acute-lymphoblastic-leukemia
#14
Á Vojcek, G Pajor, D Alpár, R Mátics, L Pótó, K Szuhai, L Pajor
BACKGROUND: High hyperdiploid (HeH) pre-B pediatric acute lymphoblastic leukemia (B-pALL) is known to be heterogeneous by prognosis, but the stratification principals according to conventional cytogenetic analysis (CCA) are equivocal. PROCEDURE: Untreated bone marrow samples of 214 B-pALL patients were previously classified according to the modal numbers (iMN8) based on the gains of the chromosomes 4, 6, 10, 14, 17, 18, 21, and X as revealed by consecutive and correlated 2×4 color interphase fluorescence in situ hybridization, and at least five years of follow up data were analyzed...
January 2017: Leukemia Research
https://www.readbyqxmd.com/read/27834760/surgical-treatment-for-double-outlet-right-ventricle-with-pulmonary-outflow-tract-obstruction
#15
Qingyu Wu, Yongqiang Jin, Hongyin Li, Mingkui Zhang
BACKGROUND: Double outlet right ventricle (DORV) is a conotruncal anomaly that is a defining element of many types of complex congenital heart disease. Because of a big variety of pathology, there are still some controversies with respect to the definition, classification, and surgical treatment. We report our experience with surgical treatment for DORV (as defined by the "90% rule") with pulmonary outflow tract obstruction (POTO). METHODS: From July 2005 to July 2015, 90 patients underwent surgical treatment of DORV with POTO at the First Hospital of Tsinghua University...
November 2016: World Journal for Pediatric & Congenital Heart Surgery
https://www.readbyqxmd.com/read/27592383/indeed-integrated-differential-expression-and-differential-network-analysis-of-omic-data-for-biomarker-discovery
#16
Yiming Zuo, Yi Cui, Cristina Di Poto, Rency S Varghese, Guoqiang Yu, Ruijiang Li, Habtom W Ressom
Differential expression (DE) analysis is commonly used to identify biomarker candidates that have significant changes in their expression levels between distinct biological groups. One drawback of DE analysis is that it only considers the changes on single biomolecule level. Recently, differential network (DN) analysis has become popular due to its capability to measure the changes on biomolecular pair level. In DN analysis, network is typically built based on correlation and biomarker candidates are selected by investigating the network topology...
December 1, 2016: Methods: a Companion to Methods in Enzymology
https://www.readbyqxmd.com/read/27535232/topic-model-based-mass-spectrometric-data-analysis-in-cancer-biomarker-discovery-studies
#17
Minkun Wang, Tsung-Heng Tsai, Cristina Di Poto, Alessia Ferrarini, Guoqiang Yu, Habtom W Ressom
BACKGROUND: A fundamental challenge in quantitation of biomolecules for cancer biomarker discovery is owing to the heterogeneous nature of human biospecimens. Although this issue has been a subject of discussion in cancer genomic studies, it has not yet been rigorously investigated in mass spectrometry based proteomic and metabolomic studies. Purification of mass spectometric data is highly desired prior to subsequent analysis, e.g., quantitative comparison of the abundance of biomolecules in biological samples...
August 18, 2016: BMC Genomics
https://www.readbyqxmd.com/read/27181574/a-new-method-and-mass-spectrometer-design-for-tof-sims-parallel-imaging-ms-ms
#18
Gregory L Fisher, Anne L Bruinen, Nina Ogrinc Potočnik, John S Hammond, Scott R Bryan, Paul E Larson, Ron M A Heeren
We report a method for the unambiguous identification of molecules in biological and materials specimens at high practical lateral resolution using a new TOF-SIMS parallel imaging MS/MS spectrometer. The tandem mass spectrometry imaging reported here is based on the precise monoisotopic selection of precursor ions from a TOF-SIMS secondary ion stream followed by the parallel and synchronous collection of the product ion data. Thus, our new method enables simultaneous surface screening of a complex matrix chemistry with TOF-SIMS (MS(1)) imaging and targeted identification of matrix components with MS/MS (MS(2)) imaging...
June 21, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/27180608/spatial-autocorrelation-in-mass-spectrometry-imaging
#19
Alberto Cassese, Shane R Ellis, Nina Ogrinc Potočnik, Elke Burgermeister, Matthias Ebert, Axel Walch, Arn M J M van den Maagdenberg, Liam A McDonnell, Ron M A Heeren, Benjamin Balluff
Mass spectrometry imaging (MSI) is a powerful molecular imaging technique. In microprobe MSI, images are created through a grid-wise interrogation of individual spots by mass spectrometry across a surface. Classical statistical tests for within-sample comparisons fail as close-by measurement spots violate the assumption of independence of these tests, which can lead to an increased false-discovery rate. For spatial data, this effect is referred to as spatial autocorrelation. In this study, we investigated spatial autocorrelation in three different matrix-assisted laser desorption/ionization MSI data sets...
June 7, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/27124736/education-on-exposure-to-and-management-of-vascular-anomalies-during-otolaryngology-residency-and-pediatric-otolaryngology-fellowship
#20
Robert Chun, Noel Jabbour, Karthik Balakrishnan, Nancy Bauman, David H Darrow, Ravindhra Elluru, J Fredrik Grimmer, Jonathan Perkins, Gresham Richter, Jennifer Shin
IMPORTANCE: The field of vascular anomalies presents diverse challenges in diagnosis and management. Although many lesions involve the head and neck, training in vascular anomalies is not universally included in otolaryngology residencies and pediatric otolaryngology (POTO) fellowships. OBJECTIVE: To explore the education in, exposure to, and comfort level of otolaryngology trainees with vascular anomalies. DESIGN, SETTING, AND PARTICIPANTS: A survey was distributed to 39 POTO fellows and 44 residents in postgraduate year 5 who matched into POTO fellowships from April 22 through June 16, 2014...
July 1, 2016: JAMA Otolaryngology—Head & Neck Surgery
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