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Compartement syndrome

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https://www.readbyqxmd.com/read/28431416/caring-for-critically-injured-children-an-analysis-of-56-pediatric-damage-control-laparotomies
#1
Miguel A Villalobos, Joshua P Hazelton, Rachel L Choron, Lisa Capano-Wehrle, Krystal Hunter, John P Gaughan, Steven E Ross, Mark J Seamon
BACKGROUND: Injury is the leading cause of death in children under 18 years. Damage control principles have been extensively studied in adults but remain relatively unstudied in children. Our primary study objective was to evaluate the use of damage control laparotomy (DCL) in critically injured children. METHODS: An American College of Surgeons-verified Level 1 trauma center review (1996-2013) of pediatric trauma laparotomies was undertaken. Exclusion criteria included: age older than 18 years, laparotomy for abdominal compartment syndrome or delayed longer than 2 hours after admission...
May 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28428247/induction-of-cell-death-and-gain-of-function-properties-of-connexin26-mutants-predict-severity-of-skin-disorders-and-hearing-loss
#2
Eric R Press, Qing Shao, John J Kelly, Katrina Chin, Anton Alaga, Dale W Laird
Connexin26 (Cx26) is a gap junction protein that oligomerizes in the cell to form hexameric transmembrane channels called connexons. Cell surface connexons dock between adjacent cells to allow for gap junctional intercellular communication. Numerous autosomal dominant mutations in the Cx26 encoding GJB2 gene lead to many skin disorders and sensorineural hearing loss. Although some insights have been gained into the pathogenesis of these diseases, it is not fully understood how distinct GJB2 mutations result in hearing loss alone or in skin pathologies with comorbid hearing loss...
April 20, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28424125/thromboelastography-utilization-in-delayed-recurrent-coagulopathy-after-severe-eastern-diamondback-rattlesnake-envenomation
#3
Katherine M McBride, William Bromberg, James Dunne
Venomous snakebites are fairly common in the United States and can present with a wide range of symptoms. A 48-year-old man presented after Eastern Diamondback rattlesnake envenomation. His hospital course was complicated by right leg compartment syndrome and delayed recurrent coagulopathy, requiring multiple doses of Crotalidae Polyvalent Immune Fab (CroFab) antivenom and transfusions. Thromboelastography was used as an adjunct to standard coagulation studies in monitoring his delayed recurrent coagulopathy...
April 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/28421958/acute-limb-compartment-syndrome-in-the-lower-leg-following-trauma-assessment-in-the-intensive-care-unit
#4
Emma Limbert, Julie Santy-Tomlinson
Acute limb compartment syndrome (ALCS) is a serious complication of traumatic injury. Although ALCS can occur in any limb, it most commonly occurs following injury to the lower leg, particularly in fractures of the tibia. Practitioners should recognise and treat ALCS as early as possible to prevent the development of further, potentially serious, complications. Most of the literature recommends that patients at risk of ALCS should be carefully monitored, with a focus on pain as the main symptom. However, patients in the intensive care unit (ICU) who are unconscious or sedated may be unable to report pain or are unreliable in doing so, therefore it is necessary to consider alternative assessments for ALCS...
April 19, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28408480/eogt-and-o-glcnac-on-secreted-and-membrane-proteins
#5
REVIEW
Shweta Varshney, Pamela Stanley
Here, we describe a recently discovered O-GlcNAc transferase termed EOGT for EGF domain-specific O-GlcNAc transferase. EOGT transfers GlcNAc (N-acetylglucosamine) to Ser or Thr in secreted and membrane proteins that contain one or more epidermal growth factor-like repeats with a specific consensus sequence. Thus, EOGT is distinct from OGT, the O-GlcNAc transferase, that transfers GlcNAc to Ser/Thr in proteins of the cytoplasm or nucleus. EOGT and OGT are in separate cellular compartments and have mostly distinct substrates, although both can act on cytoplasmic (OGT) and lumenal (EOGT) domains of transmembrane proteins...
April 15, 2017: Biochemical Society Transactions
https://www.readbyqxmd.com/read/28405091/ambulatory-extracorporeal-membrane-oxygenation-with-subclavian-venoarterial-cannulation-to-increase-mobility-and-recovery-in-a-patient-awaiting-cardiac-transplantation
#6
Samuel Jacob, Juan C MacHannaford, Themistokles Chamogeorgakis, Gonzalo V Gonzalez-Stawinski, Joost Felius, Aldo E Rafael, Rajasekhar S Malyala, Brian Lima
Venoarterial extracorporeal membrane oxygenation (ECMO) can provide temporary cardiopulmonary support for patients in hemodynamic extremis or refractory heart failure until more durable therapies-such as cardiac transplantation or a left ventricular assist device-can be safely implemented. Conventional ECMO cannulation strategies commonly employ the femoral artery and vein, constraining the patients to the supine position for the duration of ECMO support. We have recently adopted a modified cannulation approach to promote patient mobility, rehabilitation, and faster recovery and to mitigate complications associated with femoral arterial cannulation, such as limb ischemia and compartment syndrome...
April 2017: Proceedings of the Baylor University Medical Center
https://www.readbyqxmd.com/read/28386229/clc-channels-and-transporters-structure-physiological-functions-and-implications-in-human-chloride-channelopathies
#7
REVIEW
Diogo R Poroca, Ryan M Pelis, Valérie M Chappe
The discovery of ClC proteins at the beginning of the 1990s was important for the development of the Cl(-) transport research field. ClCs form a large family of proteins that mediate voltage-dependent transport of Cl(-) ions across cell membranes. They are expressed in both plasma and intracellular membranes of cells from almost all living organisms. ClC proteins form transmembrane dimers, in which each monomer displays independent ion conductance. Eukaryotic members also possess a large cytoplasmic domain containing two CBS domains, which are involved in transport modulation...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28385655/incidence-and-risk-factors-for-surgical-site-infection-after-open-reduction-and-internal-fixation-of-tibial-plateau-fracture-a-systematic-review-and-meta-analysis
#8
REVIEW
Jiashen Shao, Hengrui Chang, Yanbin Zhu, Wei Chen, Zhanle Zheng, Huixin Zhang, Yingze Zhang
BACKGROUND: This study aimed to quantitatively summarize the risk factors associated with surgical site infection after open reduction and internal fixation of tibial plateau fracture. METHODS: Medline, Embase, CNKI, Wanfang database and Cochrane central database were searched for relevant original studies from database inception to October 2016. Eligible studies had to meet quality assessment criteria according to the Newcastle-Ottawa Scale, and had to evaluate the risk factors for surgical site infection after open reduction and internal fixation of tibial plateau fracture...
April 4, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28384934/giant-inguinal-herniae-managed-by-primary-repair-a-case-series
#9
Madhur Anand, Ranendra Hajong, Narang Naku, Debobratta Hajong, K Lenish Singh
Giant inguinal hernia are usually found in developing countries due to delay in seeking medical attention. The management of such hernias may sometimes require procedures to increase the intra-peritoneal capacity prior to the repair of the giant hernia. Otherwise patients may develop abdominal compartment syndrome leading to various unwanted complications. Primary repair of giant hernias are possible in some cases without having significant post-operative complications. In this present case series, we have managed a total of four patients of giant inguinal hernia by primary repair without much post-operative complications...
February 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28382374/proximal-peroneus-longus-tear-rare-case-in-a-teenage-athlete-and-review-of-the-literature
#10
Matthew Winfeld, Nancy Chauvin
We present the case of a 15-year-old teenager who sustained an ankle inversion injury while playing American football, which yielded only minimal pain, but also foot numbness and a lateral leg bulge. Magnetic resonance imaging evaluation revealed a proximal peroneal tear. These rare injuries are often associated with compartment syndrome, a surgical emergency, which was ultimately excluded clinically in this patient. Relevant anatomy, mechanism of injury, and clinical manifestations are discussed.
April 5, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/28382039/genetic-and-epigenetic-determinants-in-autoinflammatory-diseases
#11
REVIEW
Damiana Álvarez-Errico, Roser Vento-Tormo, Esteban Ballestar
The concept of autoinflammation has evolved over the past 20 years, beginning with the discovery that mutations in the Mediterranean Fever (MEFV) gene were causative of Familial Mediterranean Fever. Currently, autoinflammatory diseases comprise a wide range of disorders with the common features of recurrent fever attacks, prevalence of hyperreactive innate immune cells, and signs of inflammation that can be systemic or organ specific in the absence of pathogenic infection of autoimmunity. Innate immune cells from the myeloid compartment are the main effectors of uncontrolled inflammation that is caused in great extent by the overproduction of inflammatory cytokines such as IL-1β and IL-18...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28381988/increased-excitatory-synaptic-transmission-of-dentate-granule-neurons-in-mice-lacking-psd-95-interacting-adhesion-molecule-neph2-kirrel3-during-the-early-postnatal-period
#12
Junyeop D Roh, Su-Yeon Choi, Yi Sul Cho, Tae-Yong Choi, Jong-Sil Park, Tyler Cutforth, Woosuk Chung, Hanwool Park, Dongsoo Lee, Myeong-Heui Kim, Yeunkum Lee, Seojung Mo, Jeong-Seop Rhee, Hyun Kim, Jaewon Ko, Se-Young Choi, Yong Chul Bae, Kang Shen, Eunjoon Kim, Kihoon Han
Copy number variants and point mutations of NEPH2 (also called KIRREL3) gene encoding an immunoglobulin (Ig) superfamily adhesion molecule have been linked to autism spectrum disorders, intellectual disability and neurocognitive delay associated with Jacobsen syndrome, but the physiological roles of Neph2 in the mammalian brain remain largely unknown. Neph2 is highly expressed in the dentate granule (DG) neurons of the hippocampus and is localized in both dendrites and axons. It was recently shown that Neph2 is required for the formation of mossy fiber filopodia, the axon terminal structure of DG neurons forming synapses with GABAergic neurons of CA3...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28372705/editorial-commentary-fluid-extravasation-in-hip-arthroscopy-a-tough-case-just-got-much-worse
#13
EDITORIAL
Timothy J Jackson
Hip arthroscopy has its complications like any other surgery, but abdominal compartment syndrome is unique to the hip and is a complication with devastating consequences. Avoidance is the rule.
April 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/28361070/primary-psoas-sarcoma-causing-malignant-psoas-syndrome-favourable-response-to-radiotherapy
#14
Thomas A McKay, Sarah Bishop, Michael J McKay
Malignant psoas syndrome (MPS) is an uncommon condition first described by Stevens et al. MPS is caused by malignant infiltration of the psoas muscle and adjacent nerves and is characterised by (fixed) flexion deformity of the ipsilateral hip and proximal lumbosacral plexopathy. It has previously been described in relation to metastatic carcinoma, melanoma and liposarcoma, as well as non-Hodgkins lymphoma. We present the case of a 68-year-old woman with a sarcoma arising in the left psoas muscle at the level of L4 who presented with symptoms of MPS...
March 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28360503/the-role-of-copy-and-paste-function-in-orthopedic-trauma-progress-notes
#15
Wesley Winn, Irshad A Shakir, Heidi Israel, Lisa K Cannada
INTRODUCTION: The electronic medical record (EMR) is standard in institutions. While there is not concern for legibility of notes and access to charts, there is an ease of copy and paste for daily notes. This may not lead to accurate portrayal of patient's status. Our purpose was to evaluate the use of copy and paste functions in daily notes of patients with injuries at high risk for complications. METHODS: IRB approval was obtained for a retrospective review. Inclusion criteria included patients aged 18 and older treated at our Level 1 Trauma Center after implementation of Epic Systems Corporation, Verona, WI, USA...
January 2017: Journal of Clinical Orthopaedics and Trauma
https://www.readbyqxmd.com/read/28359131/-sports-injuries-and-illnesses-of-the-german-national-team-during-the-2016-olympic-summer-games-in-rio-de-janeiro
#16
Casper Grim, Thilo Hotfiel, Martin Engelhardt, Syndey Plewinski, Olav Spahl, Bernd Wolfarth
Background This article aims to survey and describe the injuries and illnesses of the German Team during the 2016 Olympic Games in Rio de Janeiro. Methods Through an electronic documentation system, injuries and illnesses requiring treatment were recorded and evaluated. An injury or illness was defined as any physical symptom that required medical attention and impaired participation in training and/or competition. The classification distinguished between type of injury (acute or overload), region and type of illness (infections, skin, allergy, etc...
January 2017: Sportverletzung Sportschaden: Organ der Gesellschaft Für Orthopädisch-Traumatologische Sportmedizin
https://www.readbyqxmd.com/read/28348556/t-cell-polarization-toward-th2-tfh2-and-th17-tfh17-in-patients-with-igg4-related-disease
#17
Aurélie Grados, Mikael Ebbo, Christelle Piperoglou, Matthieu Groh, Alexis Regent, Maxime Samson, Benjamin Terrier, Anderson Loundou, Nathalie Morel, Sylvain Audia, François Maurier, Julie Graveleau, Mohamed Hamidou, Amandine Forestier, Sylvain Palat, Emmanuelle Bernit, Bernard Bonotte, Catherine Farnarier, Jean-Robert Harlé, Nathalie Costedoat-Chalumeau, Frédéric Vély, Nicolas Schleinitz
IgG4-related disease (IgG4-RD) is a fibro-inflammatory disorder involving virtually every organ with a risk of organ dysfunction. Despite recent studies regarding B cell and T cell compartments, the disease's pathophysiology remains poorly understood. We examined and characterized subsets of circulating lymphocytes in untreated patients with active IgG4-RD. Twenty-eight consecutive patients with biopsy-proven IgG4-RD were included in a prospective, multicentric study. Lymphocytes' subsets were analyzed by flow cytometry, with analysis of TH1/TH2/TH17, TFH cells, and cytokine release by peripheral blood mononuclear cells...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28344966/lower-limb-compartment-syndrome-by-reperfusion-injury-after-treatment-of-arterial-thrombosis-post-laparoscopic-radical-hysterectomy-and-pelvic-lymph-node-dissection-for-cervical-cancer
#18
Jihee Yeon, Ye Won Jung, Shin Seok Yang, Byung Hun Kang, Mina Lee, Young Bok Ko, Jung Bo Yang, Ki Hwan Lee, Heon Jong Yoo
Compartment syndrome is a clinical condition associated with decreased blood circulation that can lead to swelling of tissue in limited space. Several factors including lithotomy position, prolonged surgery, intermittent pneumatic compressor, and reperfusion after treatment of arterial thrombosis may contribute to compartment syndrome. However, compartment syndrome rarely occurs after gynecologic surgery. In this case, the patient was diagnosed as compartment syndrome due to reperfusion injury after treatment of arterial thrombosis, which occurred after laparoscopic radical hysterectomy and pelvic lymph node dissection for cervical cancer...
March 2017: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/28344334/the-kif1a-homolog-unc-104-is-important-for-spontaneous-release-postsynaptic-density-maturation-and-perisynaptic-scaffold-organization
#19
Yao V Zhang, Shabab B Hannan, Jeannine V Kern, Doychin T Stanchev, Baran Koç, Thomas R Jahn, Tobias M Rasse
The kinesin-3 family member KIF1A has been shown to be important for experience dependent neuroplasticity. In Drosophila, amorphic mutations in the KIF1A homolog unc-104 disrupt the formation of mature boutons. Disease associated KIF1A mutations have been associated with motor and sensory dysfunctions as well as non-syndromic intellectual disability in humans. A hypomorphic mutation in the forkhead-associated domain of Unc-104, unc-104(bris), impairs active zone maturation resulting in an increased fraction of post-synaptic glutamate receptor fields that lack the active zone scaffolding protein Bruchpilot...
March 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28343011/ultrasound-characterization-of-ankle-involvement-in-l%C3%A3-fgren-syndrome
#20
Claire Goussault, Jean-David Albert, Guillaume Coiffier, François Lamer, Raphaël Guillin, Benoit Le Goff, Béatrice Bouvard, Emmanuelle Dernis, Marine Ferreyra, Grégoire Cormier, Pascal Guggenbuhl, Aleth Perdriger
BACKGROUND: Bilateral ankle arthritis is a classic diagnostic criterion for Löfgren syndrome. The objective of this study was to use ultrasonography to characterize the articular and peri-articular involvement of the ankles in patients with Löfgren syndrome. METHODS: Single-center descriptive cohort study of patients with Löfgren syndrome who underwent ultrasonography of the ankles. We collected clinical data, imaging study findings, blood test results, and joint fluid properties in patients who underwent joint aspiration...
March 22, 2017: Joint, Bone, Spine: Revue du Rhumatisme
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