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Kemal Atasayan, Tevfik Yoldemir, Sedef Ramoglu, Dilek Gogas Yavuz
OBJECTIVE: To evaluate the endothelial function and structure in patients with hirsutism in reproductive age. STUDY DESIGN: The study was conducted on 69 consecutive women admitted with complaints of hirsutism and 63 voluntary healthy women, as controls. A total of 132 subjects who applied to the Gynecology and Infertility Outpatient Clinics were included. Participants with modified Ferriman Gallway (mFG) score over 8 were considered to be hirsute. The demographic, metabolic, hormonal characteristics, risk factors of cardiovascular disease, CIMT (carotis intima media thickness) and FMD (flow-mediated dilatation) were compared between hirsute women and those in the control group...
October 3, 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Andrea Ardizzoni, Marcello Tiseo, Luca Boni, Massimo Di Maio, Lucio Buffoni, Ornella Belvedere, Francesco Grossi, Vito D'Alessandro, Filippo de Marinis, Santi Barbera, Cinzia Caroti, Adolfo Favaretto, Diego Cortinovis, Brunello Morrica, Lucia Tixi, Tino Ceschia, Salvatore Parisi, Umberto Ricardi, Andrea Grimaldi, Lucio Loreggian, Pierina Navarria, Rudolf M Huber, Chandra Belani, Paal Fr Bruswig, Giorgio Vittorio Scagliotti, Tindaro Scolaro
BACKGROUND: Chemo-radiotherapy is standard of care in the treatment of unresectable stage III NSCLC. We aimed at assessing whether the addition of concurrent taxane-chemotherapy to thoracic irradiation following chemotherapy was able to improve treatment outcome. MATERIAL AND METHODS: In PITCAP trial, patients with unresectable stage III NSCLC were randomized to receive 2 cycles of platinum-paclitaxel followed by 60-61.2Gy thoracic irradiation (control arm) or by same radiotherapy with concomitant weekly paclitaxel (experimental arm)...
October 2016: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
Luciano Moscarelli, Giulia Antognoli, Elisa Buti, Egrina Dervishi, Filippo Fani, Leonardo Caroti, Aris Tsalouchos, Elena Romoli, Giulia Ghiandai, Enrico Minetti
Observation that 1,25-Dihydroxyvitamin-D3 has an immunomodulatory effect on innate and adaptive immunity raises the possible effect on clinical graft outcome. Aim of this study was to evaluate the correlation of biopsy-proven acute rejection, CMV infection, BKV infection, with 1,25-Dihydroxyvitamin-D3 deficiency and the benefit of calcitriol supplementation before and during the transplantation. Risk factors and kidney graft function were also evaluated. All RTRs received induction therapy with basiliximab, cyclosporine, mycophenolic acid, and steroids...
October 2016: Clinical Transplantation
Dexuan Wang, Yiqian Zhang, Jinhua Han, Shufang Pan, Ning Xu, Xiuyan Feng, Zhizhi Zhuang, Courtney Caroti, Jieqiu Zhuang, Robert S Hoover, Dingying Gu, Qiyi Zeng, Hui Cai
BACKGROUND: WNK kinase is a serine/threonine kinase that plays an important role in normal blood pressure homeostasis. WNK3 was previously found to enhance the activity of sodium chloride cotransporter (NCC) in Xenopus oocyte. However, the mechanism through which it works remains unclear. METHODS: Using overexpression and siRNA knock-down techniques, the effects of WNK3 on NCC in both Cos-7 and mouse distal convoluted cells were analyzed by Western blot. RESULTS: We found that WNK3 significantly increased NCC protein expression in a dose-dependent manner...
2016: Nephron
Mingli Ji, Yuxia Wang, Lei Wang, Liping Chen, Jing Li
Xuebijing (XBJ) is a Chinese herbal preparation. Previous studies have demonstrated that XBJ injection is able to inhibit the uncontrolled release of endogenous inflammatory mediators, attenuate inflammation, and alleviate organ damage. However, there are no relevant reports on the protective effect of XBJ against left ventricular ischemia/reperfusion (I/R)-induced acute lung injury (ALI). Therefore, the aim of the present study was to evaluate the protective effect of XBJ on ALI induced by left ventricular I/R, and provide evidence for the clinical application of XBJ...
July 2016: Experimental and Therapeutic Medicine
K Witter, Z Tonar, H Schöpper
Tunica adventitia or tunica externa is the outer layer of the blood vessel wall. It consists of connective tissue with vasa and nervi vasorum and plays a key role in vascular health. The aim of our study was to compare the wall layers beyond tunica media in arteries of different type and location. The following arteries of pig, dog and cat were processed histologically and analysed by light microscopy: aorta ascendens, arcus aortae, aorta thoracica, aorta abdominalis, arteria (a.) femoralis, a. tibialis cranialis, a...
June 10, 2016: Anatomia, Histologia, Embryologia
Radostina Vlaeva Cherneva, Zheina Vlaeva Cherneva, Ognian Borisov Georgiev, Daniela Stoichkova Petrova, Julia Ivanova Petrova
BACKGROUND: Oxidative stress and inflammation are assumed as the main pathological triggers for vascular damage in hypersomnolent obstructive sleep apnoea (OSA) patients, whereas their exact role in less symptomatic population is currently unknown. AIM: To determine whether oxidative stress (urinary 8-isoprostane concentration) and inflammation (plasma resistin levels) are associated with vascular damage in non-hypersomnolent (Epworth Sleep Score <11) OSA patients...
June 3, 2016: Clinical Physiology and Functional Imaging
Norbert Weiss, Johannes Gerber, Christian Reeps
No abstract text is available yet for this article.
May 2016: Deutsche Medizinische Wochenschrift
T Hummel, S H Meves, K Rüdiger, A Mügge, A Mumme, B Burkert, D Mühlberger, H Neubauer
BACKGROUND: Research has revealed that a decreased antiplatelet effect (low response [LR]/high on-treatment platelet reactivity [HPR]) of acetylsalicylic acid (ASA) and clopidogrel is associated with an increased risk of thromboembolic events. There are extensive ASA low response (ALR) and clopidogrel low response (CLR) prevalence data in the literature, but there are only a few studies concerning vascular surgical patients. The aim of this study was to examine the prevalence and risk factors of ALR and CLR in vascular surgical patients...
May 2016: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
P Carta, B Bigazzi, E Buti, G Antognoli, L Di Maria, L Caroti, E E Minetti
We compared retrospectively the level of hemoglobin and the percentage of patients with anemia among 59 kidney transplant recipients receiving everolimus, cyclosporine, and corticosteroids and 128 treated with cyclosporine, mycophenolic acid, and corticosteroids. We also compared age at the time of transplantation, sex and ferritine, serum creatinine, creatinine clearance, folic acid, cyanocobalamine levels, use od recombinant erythropoietin, mean corpuscolar volume at the last ambulatory control. Statistical analysis included Student t test, χ(2) test, and logistic regression...
March 2016: Transplantation Proceedings
G Bersani, F S Bersani, E Caroti, P Russo, G Albano, G Valeriani, C Imperatori, A Minichino, G Manuali, O Corazza
OBJECTIVE: Cannabis use is frequent among depressed patients and may lead to the so-called "amotivational syndrome", which combines symptoms of affective flattening and loss of emotional reactivity (i.e. the so-called "negative" symptomatology). The aim of this study was to investigate the negative symptomatology in depressed patients with concomitant cannabis use disorders (CUDs) in comparison with depressed patients without CUDs. PATIENTS AND METHODS: Fifty-one patients with a diagnosis of Major Depressive Disorder (MDD) and concomitant CUD and fifty-one MDD patients were enrolled in the study...
2016: European Review for Medical and Pharmacological Sciences
Haley D O'Brien
The cranial arterial pattern of artiodactyls deviates significantly from the typical mammalian pattern. One of the most striking atypical features is the rete mirabile epidurale: a subdural arterial meshwork that functionally and anatomically replaces the arteria carotis interna. This meshwork facilitates an exceptional ability to cool the brain, and was thought to be present in all artiodactyls. Recent research, however, has found that species of mouse deer (Artiodactyla: Tragulidae) endemic to the Malay Archipelago possess a complete a...
2015: PeerJ
Zehra Esra Önal, Levent Soydan, Hatice Eren Öztürk, Çiğdem Sağ, Tamay Gürbüz, Çağatay Nuhoğlu, Mehmet Masum Şimşek
BACKGROUND: We aimed to evaluate the association between hyperlipidemia and carotid intima media thickness in obese children, compared to non-obese ones. METHODS: Two hundred (110 girls, 90 boys) children aged between 6 and 15 years participated in this study. The obese group included 53 girls, 47 boys whose body mass indices (BMI) above 95th percentile, the control group included 57 girls, 43 boys who had normal weight. Fasting total cholesterol, triglyceride, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) levels were measured...
February 1, 2016: Journal of Pediatric Endocrinology & Metabolism: JPEM
V Ivaškevičius, A Thomas, A Biswas, H Ensikat, U Schmitt, S Horneff, A Pavlova, B Poetzsch, J Oldenburg
UNLABELLED: Inherited fibrinogen (FG) disorders are rare and result in quantitative or/and qualitative FG deficiency. While the majority of patients with clinically relevant FG deficiencies demonstrate a bleeding phenotype, a subset of patients are at increased risk of thrombosis. PATIENTS AND METHODS: We report a 54-years old man presenting with a thrombophilic phenotype characterized by two episodes of unprovoked venous thrombosis and a deep vein thrombosis several weeks after myocardial infarction...
2015: Hämostaseologie
K M Vakhitov
This research evaluated a long-term passability and geometric stability in the area of plasty at the first-second days and after 6, 12,48 months after surgical reconstruction in 35 patients, who underwent endarectomy. The plasty of arteriotomic opening was performed using autovenous patch (segment of saphenous vein) in 19 patients. An application of synthetical patch (Carotid patch 6 mm) was carried out in 16 cases. According to obtained data, an increase of diameter in bifurcation area of arteria carotis was revealed in group of patients with autovenous plasty 15 (78,95%) at the first 12 months after operation...
2015: Vestnik Khirurgii Imeni I. I. Grekova
Francesca Caroti, Silvia Urbansky, Maike Wosch, Steffen Lemke
To understand how and when developmental traits of the fruit fly Drosophila melanogaster originated during the course of insect evolution, similar traits are functionally studied in variably related satellite species. The experimental toolkit available for relevant fly models typically comprises gene expression and loss as well as gain-of-function analyses. Here, we extend the set of available molecular tools to piggyBac-based germ line transformation in two satellite fly models, Megaselia abdita and Chironomus riparius...
June 2015: Development Genes and Evolution
Nebojga Stojanović, Ivica Stefanović, Aleksandar Kostić, Misa Radisavejević, Dragan Stojanov, Sladjana Petrović
INTRODUCTION: The forming of the blood vessels network configuration at the base of the brain and interconnecting of blood vessels during the embryogenesis is directly related to the phylogenetic development of the brain and brain structures. A blood vessel configuration at the brain base, in the form of a ring or a hexagon, stands in direct relation to the perfusion needs of certain parts of the brain during its primary differentiation. The aim of this paper was to determine the incidence of certain blood vessel configurations at the base of the brain and understanding their symmetry or asymmetry...
April 2015: Vojnosanitetski Pregled. Military-medical and Pharmaceutical Review
Leonardo Caroti, Lorenzo Di Maria, Paolo Carta, Luciano Moscarelli, Calogero Cirami, Enrico Eugenio Minetti
Atypical haemolytic uraemic syndrome (aHUS) is a rare disease characterized by thrombocytopenia, microangiopathic haemolytic anaemia and renal impairment. Mutations in genes encoding inhibitors of the alternative pathway of the complement system are involved in ∼50% of the cases. Thrombomodulin (THBD) gene mutations occur in ∼3-5% of the cases. The risk of aHUS recurrence after kidney transplantation depends on the complement abnormality involved. In all three cases of THBD mutation reported to date, aHUS recurred after kidney transplantation (KT) with early graft loss...
June 2015: Clinical Kidney Journal
Luciano Moscarelli, Maria Zanazzi, Giuseppina Rosso, Silvia Farsetti, Leonardo Caroti, Filomena Annunziata, Nunzia Paudice, Elisabetta Bertoni, Maurizio Salvadori
Cytomegalovirus (CMV) is an important and well-described opportunistic virus in renal transplant recipients (RTRs) with infection occurring mainly after the first month post-renal transplant. CMV can present as primary infection, reinfection or reactivation of latent disease. Skin manifestations are rare and variable, and diagnosis is often delayed. We present one case of skin CMV ulcer of perineal areas without systemic symptoms of CMV disease and a negative quantitative polymerase chain reaction. This case serves to illustrate the protean nature of CMV disease in RTR...
February 2011: NDT Plus
Paolo Carta, Lorenzo Di Maria, Leonardo Caroti, Elisa Buti, Giulia Antognoli, Enrico Eugenio Minetti
The role of anti-human leukocyte antigens DQ region (HLA-DQ) in transplantation is historically less studied than HLA-DR and HLA class I regions, but several studies are demonstrating that anti HLA-DQ antibodies are among the most frequent anti HLA antibodies that develop after transplantation and can have great influence on the developing of humoral rejection and graft loss. In this article we review the gene structure and nomenclature of the HLA-DQ region, the role of anti HLA-DQ antibodies after and before transplantation and briefly the associations of particular HLA-DQ alleles and other diseases...
July 2015: Transplantation Reviews
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