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chronical kidney decease

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https://www.readbyqxmd.com/read/28062320/melanised-fungal-infections-in-kidney-transplant-recipients-contributions-to-optimize-the-clinical-management
#1
Daniel Wagner de Castro Lima Santos, Luis Fernando Aranha Camargo, Sarah Santos Gonçalves, Marília Marufuji Ogawa, Jane Tomimori, Milvia Maria Simões E Silva Enokihara, José Osmar Medina Pestana, Arnaldo Lopes Colombo
OBJECTIVES: This is a retrospective and observational study addressing clinical and therapeutic aspects of melanised fungal infections in kidney transplant recipients. METHODS: We retrospectively reviewed medical records of all patients admitted between January 1996 and December 2013 in a single institution who developed infections by melanised fungi. RESULTS: We reported 56 patients aging between 30 and 74 years with phaeohyphomycosis or chromoblastomycosis (0...
January 3, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28009780/kidney-transplant-with-low-levels-of-dsa-or-low-positive-b-flow-crossmatch-an-underappreciated-option-for-highly-sensitized-transplant-candidates
#2
Carrie Schinstock, Manish Gandhi, Wisit Cheungpasitporn, Donald Mitema, Mikel Prieto, Patrick Dean, Lynn Cornell, Fernando Cosio, Mark Stegall
BACKGROUND: Avoiding donor specific antibody (DSA) is difficult for sensitized patients. Improved understanding of the risk of low level DSA is needed. METHODS: We retrospectively compared the outcomes of 954 patients transplanted with varied levels of baseline DSA detected by single antigen beads and B flow cytometric crossmatch (XM). Patients were grouped as follows: -DSA/-XM, +DSA/-XM, +DSA/low+XM, +DSA/high+XM, and -DSA/+XM and followed for a mean of 4.1±1...
December 22, 2016: Transplantation
https://www.readbyqxmd.com/read/27994857/adenine-phosphoribosyltransferase-deficiency-in-the-united-kingdom-two-novel-mutations-and-a-cross-sectional-survey
#3
Gowrie S Balasubramaniam, Monica Arenas-Hernandez, Emilia Escuredo, Lynette Fairbanks, Tony Marinaki, Sarah Mapplebeck, Michael Sheaff, Michael K Almond
BACKGROUND: Adenine phosphoribosyltransferase deficiency is an inborn error of metabolism that can cause kidney disease from crystalline nephropathy or kidney stones. METHODS: We present three cases from a single centre with varied presentations to illustrate how increasing awareness led to better patient identification. We then undertook a cross-sectional survey of all the patients identified from the Purine Research Laboratory in the UK since 1974. RESULTS: Our index case presented with recurrent nephrolithiasis and was diagnosed on stone analysis, the second case presented with acute kidney injury and the third case was identified from a biopsy undertaken for acute on chronic kidney injury...
December 2016: Clinical Kidney Journal
https://www.readbyqxmd.com/read/27981393/hyperparathyroidism-and-increased-fractional-excretion-of-phosphate-predict-allograft-loss-in-long-term-kidney-transplant-recipients
#4
Sumanee Prakobsuk, Supinda Sirilak, Kotcharat Vipattawat, Pahnwat T Taweesedt, Vasant Sumethkul, Surasak Kantachuvesiri, Sinee Disthabanchong
BACKGROUND: After kidney transplantation, fibroblast growth factor-23 (FGF-23) normally returns to baseline within 1 year whereas hyperparathyroidism persists in most kidney transplant (KT) recipients. As a result, serum phosphate remains relatively low in association with increased serum calcium and urinary phosphate excretion when compared to chronic kidney disease patients. The relationship between mineral metabolism and outcomes in long-term KT recipients has not been extensively studied...
December 16, 2016: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/27914702/renal-xenotransplantation-experimental-progress-and-clinical-prospects
#5
Martin Wijkstrom, Hayato Iwase, Wayne Paris, Hidetaka Hara, Mohamed Ezzelarab, David K C Cooper
There are >100,000 patients waiting for kidney transplants in the United States and a vast need worldwide. Xenotransplantation, in the form of the transplantation of kidneys from genetically engineered pigs, offers the possibility of overcoming the chronic shortage of deceased and living human donors. These genetic manipulations can take the form of (i) knockout of pig genes that are responsible for the expression of antigens against which the primate (human or nonhuman primate) has natural "preformed" antibodies that bind and initiate complement-mediated destruction or (ii) the insertion of human transgenes that provide protection against the human complement, coagulation, or inflammatory responses...
November 30, 2016: Kidney International
https://www.readbyqxmd.com/read/27779800/the-expanded-criteria-donor-for-kidney-transplant-not-a-nearly-new-car
#6
Johan De Meester
No abstract text is available yet for this article.
January 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/27776444/impact-of-acute-kidney-injury-on-renal-allograft-survival
#7
Mani Nagarajan, Sakthirajan Ramanathan, Jeyachandran Dhanapriya, Thanigachalam Dineshkumar, T Bala Subramaniyan, Natarajan Gopalakrishnan
BACKGROUND: Acute kidney injury (AKI) is one of the major determinants of graft survival in kidney transplantation (KTx). Renal Transplant recipients are more vulnerable to develop AKI than general population. AKI in the transplant recipient differs from community acquired, in terms of risk factors, etiology and outcome. Our aim was to study the incidence, risk factors, etiology, outcome and the impact of AKI on graft survival. METHODS: A retrospective analysis of 219 renal transplant recipients (both live and deceased donor) was done...
October 24, 2016: Renal Failure
https://www.readbyqxmd.com/read/27769903/pre-existing-risk-factors-for-in-hospital-death-among-older-patients-could-be-used-to-initiate-end-of-life-discussions-rather-than-rapid-response-system-calls-a-case-control-study
#8
Magnolia Cardona-Morrell, Amanda Chapman, Robin M Turner, Ebony Lewis, Blanca Gallego-Luxan, Michael Parr, Ken Hillman
AIM: To investigate associations between clinical parameters - beyond the evident physiological deterioration and limitations of medical treatment - with in-hospital death for patients receiving Rapid Response System (RRS) attendances. METHODS: Retrospective case-control analysis of clinical parameters for 328 patients aged 60 years and above at their last RRS call during admission to a single teaching hospital in the 2012-2013 calendar years. Generalised estimating equation modelling was used to compare the deceased with a randomly selected sample of those who had RRS calls and survived admission (controls), matched by age group, sex, and hospital ward...
December 2016: Resuscitation
https://www.readbyqxmd.com/read/27742280/epidemiologic-and-economic-aspects-related-to-hemodialysis-and-kidney-transplantation-in-santa-catarina-in-the-period-of-2012-2013
#9
A T Silva, L B Soares, F R L Magajewski
BACKGROUND: Chronic kidney disease (CKD) is a worldwide public health problem and is expressed by increasing amounts of patients on renal replacement therapy (RRT), with significant economic and social impacts. The aim of this work was to analyze socioeconomic and mortality aspects of CKD patients in Santa Catarina (SC), Brazil. METHODS: This was an ecologic study with the population of SC's CKD patients, who used RRT or underwent renal transplantation (RT) from 2012 to 2013...
September 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27648403/latin-american-dialysis-and-transplant-registry-experience-and-contributions-to-end-stage-renal-disease-epidemiology
#10
EDITORIAL
Ana Maria Cusumano, Guillermo Javier Rosa-Diez, Maria Carlota Gonzalez-Bedat
In 2015, 634387 million people (9% of the world's population) resided in Latin America (LA), with half of those populating Brazil and Mexico. The LA Dialysis and Transplant Registry was initiated in 1991, with the aim of collecting data on renal replacement therapy (RRT) from the 20 LA-affiliated countries. Since then, the Registry has revealed a trend of increasing prevalence and incidence of end-stage kidney disease on RRT, which is ongoing and is correlated with gross national income, life expectancy at birth, and percentage of population that is older than 65 years...
September 6, 2016: World Journal of Nephrology
https://www.readbyqxmd.com/read/27597771/successful-treatment-of-a-hepatitis-c-positive-patient-who-received-kidney-transplant-from-a-hepatitis-c-positive-donor-a-case-report
#11
Ioannis Papayannis, P Patel
Kidney transplantation from hepatitis C virus (HCV)-positive donors to HCV-positive recipients has always been controversial regarding the safety and the outcomes. In the posttransplant period, treatment of hepatitis C with interferon-based regimens could lead to serious side effects. A patient with chronic hepatitis C and nephropathy, on dialysis, underwent renal transplantation from an HCV-positive donor and received direct-acting antiviral (DAA) drugs thereafter. His renal and liver functions, as well as the hepatitis C viral load, were evaluated at predetermined intervals throughout and after his treatment...
September 2016: Progress in Transplantation
https://www.readbyqxmd.com/read/27523518/oral-health-and-mortality-in-patients-with-chronic-kidney-disease
#12
Hellevi Ruokonen, Karita Nylund, Jussi Furuholm, Jukka H Meurman, Timo Sorsa, Karoliina Kotaniemi, Fernanda Ortiz, Anna Maria Heikkinen
BACKGROUND: Factors related to mortality of patients with chronic kidney disease (CKD) were investigated to find out whether oral disease inflammatory burden or different etiology (diabetes nephropathy vs. other etiologies) of CKD could be associated with mortality. METHODS: This prospective cohort study comprised 144 adults at the predialysis stage. Clinical oral and radiologic examination was made from 2000 to 2005. Patients were followed up until August 2015 (complete follow-up time: 157 months)...
January 2017: Journal of Periodontology
https://www.readbyqxmd.com/read/27513209/inhibition-of-coagulation-proteases-xa-and-iia-decreases-ischemia-reperfusion-injuries-in-a-preclinical-renal-transplantation-model
#13
Solenne Tillet, Sébastien Giraud, Thomas Kerforne, Thibaut Saint-Yves, Sandrine Joffrion, Jean-Michel Goujon, Jerôme Cau, Gérard Mauco, Maurice Petitou, Thierry Hauet
Coagulation is an important pathway in the pathophysiology of ischemia-reperfusion injuries. In particular, deceased after circulatory death (DCD) donors undergo a no-flow period, a strong activator of coagulation. Hence, therapies influencing the coagulation cascade must be developed. We evaluated the effect of a new highly specific and effective anti-Xa/IIa molecule, with an integrated innovative antidote site (EP217609), in a porcine preclinical model mimicking injuries observed in DCD donor kidney transplantation...
July 25, 2016: Translational Research: the Journal of Laboratory and Clinical Medicine
https://www.readbyqxmd.com/read/27509587/advances-and-challenges-in-renal-transplantation-in-latin-america
#14
Luis E Morales-Buenrostro
Latin America is a region made up of 33 countries that share many characteristics with each other. Since the first kidney transplant in Argentina in 1957, most of the Latin American countries have had a continuous increase in renal transplant activity, accounting for an increase in the total number of kidney transplants over time. In the last years, several advances have been made in the area of renal transplantation in Latin America: There are transplantation activities in almost all countries, the kidney transplantation rate from deceased donors has steadily increased, and almost all the countries have an appropriate legislation for transplantation activity...
2016: Clinical Nephrology
https://www.readbyqxmd.com/read/27508626/-op-2b-07-high-pulse-pressure-and-outcome-in-kidney-transplantation-results-from-the-collaborative-transplant-study
#15
B Krüger, B Döhler, G Opelz, H Mundt, B K Krämer, C Süsal
OBJECTIVE: Systolic blood pressure (SBP) and diastolic blood pressure (DBP) are important predictors of graft and patient survival in renal transplant recipients. Pulse pressure (PP) has been associated with cardiovascular and renal morbidity and mortality in the general population and patients with chronic kidney disease (CKD). DESIGN AND METHOD: Adult recipients of first deceased donor kidney grafts transplanted between 1995 and 2014 were included into the analysis for graft and patient survival if the patient had both a functioning graft and a known blood pressure reading at year 1...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27471736/prognostic-indicators-of-adverse-renal-outcome-and-death-in-acute-kidney-injury-hospital-survivors
#16
Aida Hamzić-Mehmedbašić, Senija Rašić, Merima Balavac, Damir Rebić, Marina Delić-Šarac, Azra Durak-Nalbantić
INTRODUCTION: Data regarding prognostic factors of post-discharge mortality and adverse renal function outcome in acute kidney injury (AKI) hospital survivors are scarce and controversial. OBJECTIVES: We aimed to identify predictors of post-discharge mortality and adverse renal function outcome in AKI hospital survivors. PATIENTS AND METHODS: The study group consisted of 84 AKI hospital survivors admitted to the tertiary medical center during 2-year period...
2016: Journal of Renal Injury Prevention
https://www.readbyqxmd.com/read/27469152/promotion-of-kidney-care-in-countries-with-limited-resources-how-does-the-national-kidney-foundation-of-south-africa-fare
#17
Anthony M Meyers
INTRODUCTION: An often-quoted remark is to present problems as challenges, which invariably end up in the "in-box", eventually to be swept under the carpet. The chronic kidney disease burden in the South African black population poses a challenging crisis requiring immediate intervention even in a country with limited resources. Aims, materials, and methods: The National Kidney Foundation of South Africa (NKFSA) reports on 3 major projects. The schools project is aimed at prevention, early diagnosis, and appropriate management of chronic kidney disease (CKD) on a national basis...
2016: Clinical Nephrology
https://www.readbyqxmd.com/read/27469145/burden-of-end-stage-kidney-disease-north-africa
#18
Rashad S Barsoum
Geographical, ecological, and genetic factors result in many similarities among the six main countries of the African Sahara, including the epidemiology of kidney disease. With an average incidence of 182 and prevalence of 522 patients with end-stage kidney disease (ESKD) per million population, North Africa (NA) spends $650 million on dialysis and transplantation despite an estimated annual loss of 600,000 life years. The health burden of ESKD is not limited to its directly-related morbidity and mortality but affects even more significantly other body systems, particularly the cardiovascular system...
2016: Clinical Nephrology
https://www.readbyqxmd.com/read/27358778/state-of-deceased-donor-transplantation-in-india-a-model-for-developing-countries-around-the-world
#19
REVIEW
Georgi Abraham, Madhusudan Vijayan, Natarajan Gopalakrishnan, Sunil Shroff, Joseph Amalorpavanathan, Anand Yuvaraj, Sanjeev Nair, Saravanan Sundarrajan
Renal replacement therapy (RRT) resources are scarce in India, with wide urban-rural and interstate disparities. The burden of end-stage renal disease is expected to increase further due to increasing prevalence of risk factors like diabetes mellitus. Renal transplantation, the best RRT modality, is increasing in popularity, due to improvements made in public education, the deceased donor transplantation (DDT) programme and the availability of free and affordable transplant services in government hospitals and certain non-governmental philanthropic organizations...
June 24, 2016: World Journal of Transplantation
https://www.readbyqxmd.com/read/27343849/de-novo-noncutaneous-malignancies-after-kidney-transplantation-are-associated-with-an-increased-risk-of-graft-failure-results-from-a-time-dependent-analysis-on-672-patients
#20
Tiziana Cena, Claudio Musetti, Marco Quaglia, Corrado Magnani, Piero Stratta, Vincenzo Bagnardi, Vincenzo Cantaluppi
The aim of this study was to evaluate the association between cancer occurrence and risk of graft failure in kidney transplant recipients. From November 1998 to November 2013, 672 adult patients received their first kidney transplant from a deceased donor and had a minimum follow-up of 6 months. During a median follow-up of 4.7 years (3523 patient-years), 47 patients developed a nonmelanoma skin cancer (NMSC) and 40 a noncutaneous malignancy (NCM). A total of 59 graft failures were observed. The failure rate was 6 per 100 patient-year (pt-yr) after NCM versus 1...
October 2016: Transplant International: Official Journal of the European Society for Organ Transplantation
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