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Alon Barsheshet, Valentina Kutyifa, Theodora Vamvouris, Arthur J Moss, Yitschak Biton, Leway Chen, Eugene Storozynsky, Chingping Wan, Steven J Szymkiewicz, Ilan Goldenberg
INTRODUCTION: The wearable cardioverter defibrillator (WCD) may allow stabilization until reassessment for an implantable cardioverter defibrillator (ICD) among high-risk HF patients. However, there are limited data on the WCD benefit in the acute decompensated HF setting. METHODS AND RESULTS: The Study of the Wearable Cardioverter Defibrillator in Advanced Heart-Failure Patients (SWIFT) was a prospective clinical trial carried out at two medical centers. Patients hospitalized with advanced HF symptoms and reduced left ventricular ejection function (LVEF) were enrolled and prescribed a WCD prior to discharge for a total of 3 months...
April 21, 2017: Journal of Cardiovascular Electrophysiology
Uri Landes, Tamir Bental, Alon Barsheshet, Abid Assali, Hana Vaknin Assa, Amos Levi, Katia Orvin, Ran Kornowski
OBJECTIVES: The Evolut-R (Medtronic, Inc) is a transcatheter aortic valve implantation (TAVI) system that was built on the well-established foundation of Medtronic's CoreValve device platform. Although already in extensive clinical utilization, it is unknown if the Evolut-R improves TAVI outcomes. Herein, we compared TAVI outcomes of the Evolut-R and CoreValve devices. METHODS: A propensity score 1:1 matching was conducted on 358 Evolut-R patients (n = 75) and CoreValve patients (n = 283)...
February 2017: Journal of Invasive Cardiology
Tzipora C Falik-Zaccai, Yiftah Barsheshet, Hanna Mandel, Meital Segev, Avraham Lorber, Shachaf Gelberg, Limor Kalfon, Shani Ben Haroush, Adel Shalata, Liat Gelernter-Yaniv, Sarah Chaim, Dorith Raviv Shay, Morad Khayat, Michal Werbner, Inbar Levi, Yishay Shoval, Galit Tal, Stavit Shalev, Eli Reuveni, Emily Avitan-Hersh, Eugene Vlodavsky, Liat Appl-Sarid, Dorit Goldsher, Reuven Bergman, Zvi Segal, Ora Bitterman-Deutsch, Orly Avni
Dilated cardiomyopathy (DCM) is a life-threatening disorder whose genetic basis is heterogeneous and mostly unknown. Five Arab Christian infants, aged 4-30 months from four families, were diagnosed with DCM associated with mild skin, teeth, and hair abnormalities. All passed away before age 3. A homozygous sequence variation creating a premature stop codon at PPP1R13L encoding the iASPP protein was identified in three infants and in the mother of the other two. Patients' fibroblasts and PPP1R13L-knocked down human fibroblasts presented higher expression levels of pro-inflammatory cytokine genes in response to lipopolysaccharide, as well as Ppp1r13l-knocked down murine cardiomyocytes and hearts of Ppp1r13l-deficient mice...
March 2017: EMBO Molecular Medicine
Hillel Steiner, Michael Geist, Ilan Goldenberg, Mahmoud Suleiman, Michael Glikson, Alexander Tenenbaum, Moshe Swissa, Enrique Z Fisman, Gregory Golovchiner, Boris Strasberg, Alon Barsheshet
AIMS: There are limited data regarding the effect of diabetes mellitus (DM) on the risks of both appropriate and inappropriate implantable cardioverter defibrillator (ICD) therapy. The present study was designed to compare the outcome of appropriate and inappropriate ICD therapy in patients with or without DM. METHODS AND RESULTS: The risk of a first appropriate ICD therapy for ventricular tachyarrhythmias (including anti tachycardia pacing and shock) was compared between 764 DM and 1346 non-DM patients enrolled in the national Israeli ICD registry...
December 1, 2016: Cardiovascular Diabetology
Uri Landes, Alon Barsheshet, Ariel Finkelstein, Victor Guetta, Abid Assali, Amir Halkin, Hanna Vaknin-Assa, Amit Segev, Tamir Bental, Jeremy Ben-Shoshan, Israel M Barbash, Ran Kornowski
BACKGROUND: About a decade past the first transcatheter aortic valve implantation (TAVI), data are limited regarding temporal trends accompanying its evolution from novel technology to mainstream therapy. We evaluated these trends in a large multicenter TAVI registry. HYPOTHESIS: TAVI is changing and improving with time. METHODS: Patients who underwent TAVI between January 2008 and December 2014 at 3 high-volume Israeli centers were divided into 5 time quintiles according to procedure date...
October 26, 2016: Clinical Cardiology
Pablo Codner, Amos Levi, Giuseppe Gargiulo, Fabien Praz, Kentaro Hayashida, Yusuke Watanabe, Darren Mylotte, Nicolas Debry, Marco Barbanti, Thierry Lefèvre, Thomas Modine, Johan Bosmans, Stephan Windecker, Israel Barbash, Jan-Malte Sinning, Georg Nickenig, Alon Barsheshet, Ran Kornowski
Patients with advanced chronic renal dysfunction were excluded from randomized trials of transcatheter aortic valve replacement (TAVR). The potential impact of chronic renal disease on TAVR prognosis is not fully understood. We aim to evaluate outcomes within a large cohort of patients who underwent TAVR distinguished by renal function. Baseline characteristics, procedural data, and clinical follow-up findings were collected from 10 high-volume TAVR centers in Europe, Israel, and Japan. Data were analyzed according to renal function...
September 15, 2016: American Journal of Cardiology
Eran Leshem, Mahmoud Suleiman, Avishag Laish-Farkash, Yuval Konstantino, Michael Glikson, Alon Barsheshet, Ilan Goldenberg, Yoav Michowitz
AIMS: Dual-coil leads were traditionally considered standard of care due to lower defibrillation thresholds (DFT). Higher complication rates during extraction with parallel progression in implantable cardioverter defibrillator (ICD) technology raised questions on dual coil necessity. Prior substudies found no significant outcome difference between dual and single coils, although using higher rates of DFT testing then currently practiced. We evaluated the temporal trends in implantation rates of single- vs...
October 4, 2016: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
Gustavo Goldenberg, Tamir Bental, Udi Kadmon, Ronit Zabarsky, Jairo Kusnick, Alon Barsheshet, Gregory Golovchiner, Boris Strasberg
BACKGROUND: Syncope is a common clinical condition spanning from benign to life-threatening diseases. There is sparse information on the outcomes of syncopal patients who received an implantable cardiac defibrillator (lCD) for primary prevention of sudden cardiac death (SCD). OBJECTIVES: To assess the outcomes and prognosis of patients who underwent implantable cardiac defibrillator (ICD) implantation for primary prevention of SCD and compare them to patients who presented with or without prior syncope...
June 2016: Israel Medical Association Journal: IMAJ
Alon Barsheshet, Theodora Vamvouris, Ilan Goldenberg
INTRODUCTION: Ventricular tachyarrhythmias (ventricular tachycardia and ventricular fibrillation) can lead to aborted cardiac arrest or sudden cardiac death in patients with poor left ventricular function early after acute myocardial infarction (AMI). Although it has been shown that the implantable cardioverter defibrillator (ICD) can treat ventricular tachyarrhythmias and save lives in patients with ischemic cardiomyopathy, it's use during the early phase post AMI has not been shown to reduce mortality...
July 2016: Expert Review of Medical Devices
Mustafa Husaini, Yitschak Biton, Brad Stair, Arthur J Moss, Tor Biering-Sørensen, Scott Solomon, Scott McNitt, Bronislava Polonsky, Wojciech Zareba, Alon Barsheshet, Valentina Kutyifa
BACKGROUND: It is not known whether the number of revascularizations modifies clinical outcomes in patients with ischemic cardiomyopathy (ICM) implanted with cardiac resynchronization therapy defibrillator (CRT-D) vs. an implantable cardioverter-defibrillator (ICD)-only. METHODS: In Multicenter Automatic Defibrillator Implantation Trial-Cardiac Resynchronization Therapy (MADIT-CRT), we evaluated the effect of CRT-D vs. ICD-only on heart failure (HF) or death, on ventricular tachycardia (VT), ventricular fibrillation (VF) or death, and on reverse remodeling in 592 ICM patients with left bundle branch block, by the number of pre-enrollment revascularizations (0, 1 or ≥ 2 revascularizations)...
2016: Cardiology Journal
Amir Halkin, Arie Steinvil, Guy Witberg, Alon Barsheshet, Michael Barkagan, Abid Assali, Amit Segev, Paul Fefer, Victor Guetta, Israel M Barbash, Ran Kornowski, Ariel Finkelstein
BACKGROUND: Accurate risk stratification is pivotal for appropriate selection of patients with severe symptomatic aortic stenosis for either surgical or transcatheter aortic valve replacement (TAVR). We sought to determine whether recent risk prediction models developed specifically in TAVR patients enhance prognostication in comparison with previous surgical scores used in clinical practice (EuroScore I, EuroScore II, STS). METHODS: The Israeli TAVR Registry Risk Model Accuracy Assessment (IRRMA) study utilized a multicenter prospective TAVR database (n=1327) to perform a quantitative comparison between previous risk scores developed in either surgical or TAVR populations, with the present registry serving as an independent external validation set...
July 15, 2016: International Journal of Cardiology
Guy Witberg, Alon Barsheshet, Abid Assali, Hana Vaknin-Assa, Aviv A Shaul, Katia Orvin, Moti Vaturi, Shmuel Schwartzenberg, Yaron Shapira, Alexander Sagie, Ran Kornowski
OBJECTIVES: To explore the relation between the baseline aortic valve gradient (AVG) as a continuous variable and clinical outcomes following transcatheter aortic valve implantation (TAVI) in general and specifically in patients with high-gradient aortic stenosis (AS). METHODS: We reviewed 317 consecutive patients who underwent TAVI at our institution. We investigated the relation between AVG as a continuous/categorical variable and outcome among all patients and in patients without low-flow low-gradient AS, using the Cox proportional hazard model adjusting for multiple prognostic variables...
2016: Cardiology
A Atamna, D Yahav, N Eliakim-Raz, E Goldberg, H Ben-Zvi, A Barsheshet, A Elis, J Bishara
UNLABELLED: Several studies have shown an association between exposure to statins and favorable clinical outcomes for various types of infections. We aimed to assess the impact of statin use on mortality, disease severity and complications among hospitalized patients with Clostridium difficile infection (CDI). Data were analyzed from a retrospectively collected database of 499 patients diagnosed with CDI during 2009-2014. We compared infection outcomes between 178 statin (36 %) users and 321 (64 %) non-users...
May 2016: European Journal of Clinical Microbiology & Infectious Diseases
Aviv A Shaul, Ran Kornowski, Tamir Bental, Hana Vaknin-Assa, Abid Assali, Gregory Golovchiner, Ehud Kadmon, Pablo Codner, Katia Orvin, Boris Strasberg, Alon Barsheshet
BACKGROUND: There are limited data available regarding the relationship between atrial fibrillation (AF) clinical type, oral anticoagulation (OAC) treatment, and clinical outcome after transcatheter aortic valve replacement (TAVR). The study was designed to evaluate this relationship. METHODS: We analyzed data from the Rabin Medical Center TAVR registry, including 319 consecutive patients who underwent TAVR from 2008 to 2014. Patients were divided into three groups based on their history of AF: sinus rhythm (SR), paroxysmal AF (PAF), or nonparoxysmal AF (NPAF)...
September 2016: Annals of Noninvasive Electrocardiology
Yitschak Biton, Ilan Goldenberg, Valentina Kutyifa, Jayson R Baman, Scott Solomon, Arthur J Moss, Barbara Szepietowska, Scott McNitt, Bronislava Polonsky, Wojciech Zareba, Alon Barsheshet
BACKGROUND: Relative wall thickness (RWT), defined as 2 times posterior wall thickness divided by the left ventricular (LV) diastolic diameter, is a measure of LV geometry and may be a marker for adverse events in patients with LV dysfunction. OBJECTIVES: The aim of this study was to investigate the relationship between RWT and the risk for ventricular tachyarrhythmia (VA) in patients enrolled in the MADIT-CRT (Multicenter Automatic Defibrillator Implantation Trial With Cardiac Resynchronization Therapy) study...
January 26, 2016: Journal of the American College of Cardiology
Yitschak Biton, David T Huang, Ilan Goldenberg, Spencer Rosero, Arthur J Moss, Valentina Kutyifa, Scott McNitt, Boris Strasberg, Wojciech Zareba, Alon Barsheshet
BACKGROUND: There is limited data regarding the relationship between age and inappropriate therapy among patients with an implantable cardioverter-defibrillator (ICD) and resynchronization therapy. OBJECTIVES: We aimed to investigate this relationship and the effect of ICD programming on inappropriate therapy by age. METHODS: In the Multicenter Automatic Defibrillator Implantation Trial-Reduce Inappropriate Therapy (MADIT-RIT) 1500 patients were randomized to 3 ICD programming arms: (A) conventional with ventricular tachycardia (VT) therapy ≥170; (B) high-rate cutoff with VT therapy ≥200, and (C) prolonged 60-second delay for VT therapy ≥170...
April 2016: Heart Rhythm: the Official Journal of the Heart Rhythm Society
Israel Moshe Barbash, Ariel Finkelstein, Alon Barsheshet, Amit Segev, Arie Steinvil, Abid Assali, Yanai Ben Gal, Hana Vaknin Assa, Paul Fefer, Alex Sagie, Victor Guetta, Ran Kornowski
Intermediate- or low-risk patients with severe aortic stenosis were excluded from earlier transcatheter aortic valve implantation (TAVI) clinical trials; however, they are already being treated by TAVI despite a lack of data regarding the safety and efficacy in these patients. We aimed to assess the safety and efficacy of TAVI in patients at intermediate or low risk. Patients undergoing TAVI during 2008 to 2014 were included into a shared database (n = 1,327). Procedural outcomes were adjudicated according to Valve Academic Research Consortium 2 definitions...
December 15, 2015: American Journal of Cardiology
Yitschak Biton, Ilan Goldenberg, Valentina Kutyifa, Wojciech Zareba, Barbara Szepietowska, Scott Mcnitt, Bronislava Polonsky, Alon Barsheshet, Arthur J Moss
Previous studies suggested that statin therapy reduces the risk of occurrence and recurrence of atrial fibrillation mainly in patients with coronary artery disease. Data regarding the effect of statins on the risk for the entire range of supraventricular arrhythmias (SVA) in mild heart failure (HF) with different disease causes are lacking. Multivariate Cox proportional hazards regression models were used to assess the effect of statin therapy, evaluated as a time-dependent covariate, on the risk of SVA and recurrent SVA (defined as atrial fibrillation, atrial flutter, atrial tachycardia, and supraventricular tachycardia) that were inappropriately treated with implantable cardioverter-defibrillator device in 1,790 patients enrolled in the Multicenter Automatic Defibrillator Implantation With Cardiac Resynchronization Therapy trial...
December 15, 2015: American Journal of Cardiology
Sabu Thomas, Arthur J Moss, Wojciech Zareba, Scott McNitt, Alon Barsheshet, Helmut Klein, Ilan Goldenberg, David T Huang, Yitschak Biton, Valentina Kutyifa
BACKGROUND: Cardiac resynchronization with defibrillators (CRT-D) reduces heart failure and mortality compared with defibrillators alone. Whether this applies to all ages is unclear. METHODS AND RESULTS: We assessed the association of age on heart failure and death as a post hoc analysis of the MADIT-CRT follow-up study, in which 1,281 patients with class I/II heart failure (HF) were randomized to CRT-D or implantable cardioverter-defibrillators alone. Different age groups (<60, 60-74, and ≥75 years) were evaluated over 7 years for mortality and HF events...
February 2016: Journal of Cardiac Failure
Yitschak Biton, Arthur J Moss, Valentina Kutyifa, Andrew Mathias, Saadia Sherazi, Wojciech Zareba, Scott McNitt, Bronislava Polonsky, Alon Barsheshet, Mary W Brown, Ilan Goldenberg
BACKGROUND: Previous studies have shown that low blood pressure is associated with increased mortality and heart failure (HF) in patients with left ventricular dysfunction. Cardiac resynchronization therapy (CRT) was shown to increase systolic blood pressure (SBP). Therefore, we hypothesized that treatment with CRT would provide incremental benefit in patients with lower SBP values. METHODS AND RESULTS: The independent contribution of SBP to outcome was analyzed in 1267 patients with left bundle brunch block enrolled in Multicenter Automatic Defibrillator Implantation Trial With Cardiac Resynchronization Therapy (MADIT-CRT)...
September 2015: Circulation. Heart Failure
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