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Multiple sclerosis manitoba

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https://www.readbyqxmd.com/read/27456879/adherence-and-persistence-to-drug-therapies-for-multiple-sclerosis-a-population-based-study
#1
Charity Evans, Ruth Ann Marrie, Feng Zhu, Stella Leung, Xinya Lu, Dessalegn Y Melesse, Elaine Kingwell, Yinshan Zhao, Helen Tremlett
OBJECTIVE: We aimed to estimate the prevalence and predictors of optimal adherence and persistence to the disease-modifying therapies (DMT) for multiple sclerosis (MS) in 3 Canadian provinces. METHODS: We used population-based administrative databases in British Columbia (BC), Saskatchewan, and Manitoba. All individuals receiving DMT (interferon-B-1b, interferon-B-1a, and glatiramer acetate) between 1-January-1996 and 31-December-2011 (BC), 31-March-2014 (Saskatchewan), or 31-March-2012 (Manitoba) were included...
July 2016: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/26315104/informal-caregivers-of-clients-with-neurological-conditions-profiles-patterns-and-risk-factors-for-distress-from-a-home-care-prevalence-study
#2
Lori A Mitchell, John Hirdes, Jeff W Poss, Caroline Slegers-Boyd, Hilary Caldarelli, Lynn Martin
BACKGROUND: Individuals living in the community with neurological conditions receive the majority of their care from informal caregivers. The purpose of this project was to provide a profile of caregivers of home care clients with neurological conditions. The study also examined prevalence of caregiver distress and the association between neurological conditions and other client and caregiver characteristics with distress. METHODS: The study population included Canadian home care clients in the Winnipeg Regional Health Authority in Manitoba and in the province of Ontario...
2015: BMC Health Services Research
https://www.readbyqxmd.com/read/26195046/health-care-utilization-before-and-after-intensive-care-unit-admission-in-multiple-sclerosis
#3
Ruth Ann Marrie, Charles N Bernstein, Christine A Peschken, Carol A Hitchon, Hui Chen, Randall Fransoo, Allan Garland
OBJECTIVES: The incidence of intensive care unit (ICU) admission is elevated in the multiple sclerosis (MS) population but the reasons for this are incompletely understood, as are outcomes post-ICU admission. Among MS patients we examined the association between ICU admission and health care utilization in the year preceding admission, and compared health care utilization following ICU admission among persons with MS and persons from the general population. METHODS: We used population-based administrative data from Manitoba, Canada to identify 4237 MS cases of which 2547 were incident...
July 2015: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/26019190/effect-of-comorbidity-on-mortality-in-multiple-sclerosis
#4
Ruth Ann Marrie, Lawrence Elliott, James Marriott, Michael Cossoy, James Blanchard, Stella Leung, Nancy Yu
OBJECTIVE: We aimed to compare survival in the multiple sclerosis (MS) population with a matched cohort from the general population, and to evaluate the association of comorbidity with survival in both populations. METHODS: Using population-based administrative data, we identified 5,797 persons with MS and 28,807 controls matched on sex, year of birth, and region. We estimated annual mortality rates. Using Cox proportional hazards regression, we evaluated the association between comorbidity status and mortality, stratifying by birth cohort, and adjusting for sex, socioeconomic status, and region...
July 21, 2015: Neurology
https://www.readbyqxmd.com/read/25583843/impact-of-parental-multiple-sclerosis-on-early-childhood-development-a-retrospective-cohort-study
#5
Neda Razaz, Helen Tremlett, W Thomas Boyce, Martin Guhn, K S Joseph, Ruth Ann Marrie
BACKGROUND: Exposure to parental chronic illness is associated with several adverse developmental outcomes. OBJECTIVES: We examined the association between parental multiple sclerosis (MS) and childhood developmental outcomes. METHODS: We conducted a population-based retrospective cohort study in Manitoba, Canada, using linked databases. The outcome was childhood development at 5 years of age, expressed as vulnerability (absent vs. present) on the Early Development Instrument (EDI)...
August 2015: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/25540309/comorbidity-increases-the-risk-of-hospitalizations-in-multiple-sclerosis
#6
Ruth Ann Marrie, Lawrence Elliott, James Marriott, Michael Cossoy, Aruni Tennakoon, Nancy Yu
OBJECTIVE: We aimed to evaluate the association between comorbidity and rates of hospitalization in the multiple sclerosis (MS) population as compared to a matched cohort from the general population. METHODS: Using population-based administrative data from the Canadian province of Manitoba, we identified 4,875 persons with MS and a matched general population cohort of 24,533 persons. We identified all acute care hospitalizations in the period 2007-2011. Using general linear models, we evaluated the association between comorbidity status and hospitalization rates (all-cause, non-MS-related, MS-related) in the 2 populations, adjusting for age, sex, and socioeconomic status...
January 27, 2015: Neurology
https://www.readbyqxmd.com/read/25323329/application-of-three-focused-cluster-detection-methods-to-study-geographic-variation-in-the-incidence-of-multiple-sclerosis-in-manitoba-canada
#7
Mahmoud Torabi, Chris Green, Nancy Yu, Ruth Ann Marrie
BACKGROUND: Macroscopic geographic variation in the incidence and prevalence of MS is well-recognized. Microscopic geographic variation in the distribution of MS is also recognized, but less well-studied. Most studies have focused on prevalent cases of MS, although studies of variation in disease incidence are more relevant for developing etiologic hypotheses. We aimed to study geographic variation in the incidence of MS using three different methods. METHODS: We used population-based administrative (health claims) data to identify 2,290 incident cases of MS in the province of Manitoba, Canada from 1990 to 2006...
2014: Neuroepidemiology
https://www.readbyqxmd.com/read/25085638/dramatically-changing-rates-and-reasons-for-hospitalization-in-multiple-sclerosis
#8
Ruth Ann Marrie, Lawrence Elliott, James Marriott, Michael Cossoy, James Blanchard, Aruni Tennakoon, Nancy Yu
OBJECTIVE: We aimed to describe hospitalizations in the multiple sclerosis (MS) population, and to evaluate temporal trends in hospitalizations in the MS population compared to the general population. METHODS: Using population-based administrative data, we identified 5,797 persons with MS and a matched general population cohort of 28,769 persons. Using general linear models, we evaluated temporal trends in hospitalization rates and length of stay in the 2 populations over the period 1984-2011...
September 2, 2014: Neurology
https://www.readbyqxmd.com/read/24991777/performance-of-administrative-case-definitions-for-comorbidity-in-multiple-sclerosis-in-manitoba-and-nova-scotia
#9
COMPARATIVE STUDY
R A Marrie, J D Fisk, K J Stadnyk, H Tremlett, C Wolfson, S Warren, V Bhan, B N Yu
INTRODUCTION: As the population ages and the prevalence of comorbid conditions increases, the need for feasible, validated methods of comorbidity surveillance in chronic diseases such as multiple sclerosis (MS) increases. METHODS: Using kappa (k) statistics, we evaluated the performance of administrative case definitions for comorbidities commonly observed in MS by comparing agreement between Manitoba (MB) administrative data and self-report (n = 606) and Nova Scotia (NS) administrative data and self-report (n = 1923)...
July 2014: Chronic Diseases and Injuries in Canada
https://www.readbyqxmd.com/read/24808019/intensive-care-unit-admission-in-multiple-sclerosis-increased-incidence-and-increased-mortality
#10
COMPARATIVE STUDY
Ruth Ann Marrie, Charles N Bernstein, Christine A Peschken, Carol A Hitchon, Hui Chen, Randy Fransoo, Allan Garland
OBJECTIVE: To compare the incidence of, and mortality after, intensive care unit (ICU) admission as well as the characteristics of critical illness in the multiple sclerosis (MS) population vs the general population. METHODS: We used population-based administrative data from the Canadian province of Manitoba for the period 1984 to 2010 and clinical data from 93% of admissions to provincial high-intensity adult ICUs. We identified 5,035 prevalent cases of MS and a cohort from the general population matched 5:1 on age, sex, and region of residence...
June 10, 2014: Neurology
https://www.readbyqxmd.com/read/24453744/barriers-and-facilitators-related-to-participation-in-aquafitness-programs-for-people-with-multiple-sclerosis-a-pilot-study
#11
Cara Brown, Kaitlyn Kitchen, Kaley Nicoll
Exercise and leisure activities provide physical and psychosocial benefits to people with multiple sclerosis (MS) and can enhance their quality of life. In Winnipeg, Manitoba, Canada, people with MS have reported barriers to their participation in local MS-specific aquafitness (AF) programs. Therefore, a formal exploration of the accessibility of local AF programs for people with MS was undertaken. The purpose of this phenomenological study was to identify factors that facilitate or impede participation in AF programs by individuals with MS living in Winnipeg...
2012: International Journal of MS Care
https://www.readbyqxmd.com/read/23897644/exploring-the-implications-of-small-area-variation-in-the-incidence-of-multiple-sclerosis
#12
Chris Green, Bo Nancy Yu, Ruth Ann Marrie
In this study, we describe the geospatial variation in the incidence of multiple sclerosis (MS) in Manitoba, Canada, and the sociodemographic characteristics associated with MS incidence. By using administrative health data, we identified all incident cases of MS in Manitoba from 1990 to 2006 (n = 2,290) and geocoded them to 230 neighborhoods in the City of Winnipeg and 268 municipalities in rural Manitoba. Age-standardized incidence rates for 1990-2006 (combined) were calculated for each region. By using the spatial scan statistic, we identified high-rate clusters in southwestern (incidence rate ratio (IRR) = 1...
October 1, 2013: American Journal of Epidemiology
https://www.readbyqxmd.com/read/23095852/utility-of-capture-recapture-methodology-to-assess-completeness-of-amyotrophic-lateral-sclerosis-case-ascertainment
#13
COMPARATIVE STUDY
Michael Wittie, Lorene M Nelson, Sharon Usher, Kevin Ward, Michael Benatar
BACKGROUND: With the establishment of a national amyotrophic lateral sclerosis (ALS) registry in the United States, methods are needed to ascertain the completeness of case ascertainment, especially in view of the proposal to rely largely on existing data sources. METHODS: Data about ALS patients residing in the 5-county metropolitan Atlanta area (within the State of Georgia) from 2001 to 2005 were categorized according to their source--ALS Association, clinical (Emory Healthcare, community neurologist, Veterans Health Administration, Veterans Benefits Administration), Medicare and death certificates...
2013: Neuroepidemiology
https://www.readbyqxmd.com/read/23095571/the-utility-of-administrative-data-for-surveillance-of-comorbidity-in-multiple-sclerosis-a-validation-study
#14
Ruth Ann Marrie, Bo Nancy Yu, Stella Leung, Lawrence Elliott, Patricia Caetano, Sharon Warren, Christina Wolfson, Scott B Patten, Lawrence W Svenson, Helen Tremlett, John Fisk, James F Blanchard
BACKGROUND: Although comorbidity is important in multiple sclerosis (MS), few validated methods for its assessment exist. We validated and applied administrative case definitions for several comorbidities in MS. METHODS: Using provincial administrative data we identified persons with MS and a matched general population cohort. Case definitions for chronic lung disease (CLD), epilepsy, inflammatory bowel disease (IBD), irritable bowel syndrome (IBS) and migraine were developed using administrative data, and validated against medical records...
2013: Neuroepidemiology
https://www.readbyqxmd.com/read/22889755/the-incidence-and-prevalence-of-thyroid-disease-do-not-differ-in-the-multiple-sclerosis-and-general-populations-a-validation-study-using-administrative-data
#15
Ruth Ann Marrie, Bo Nancy Yu, Stella Leung, Lawrence Elliott, Sharon Warren, Christina Wolfson, Helen Tremlett, John Fisk, James Blanchard
BACKGROUND: Prior studies of a possible increased risk of autoimmune thyroid disease (AIT) in multiple sclerosis (MS) are inconsistent. We aimed to validate and apply administrative case definitions for the surveillance of AIT in MS. METHODS: We used administrative health data to identify 4,192 persons with MS and an age-, sex- and geographically matched general population cohort (n = 20,940). We developed case definitions for AIT using International Classification of Disease-9/10 codes and prescription claims, compared them to medical records and applied them to estimate the incidence and prevalence of AIT...
2012: Neuroepidemiology
https://www.readbyqxmd.com/read/22514454/antibody-response-in-seropositive-multiple-sclerosis-patients-vaccinated-with-attenuated-live-varicella-zoster-virus
#16
R Ross, M Dawood, M Cheang, L E Nicolle
OBJECTIVE: To determine the safety and effectiveness of live attenuated varicella zoster virus (VZV) vaccine (OKA/Merck) on 50 patients with chronic progressive multiple sclerosis (MS), based on the hypothesis that VZV might be the antigen or antigen mimic of MS plus the fact that repeated high antigen doses have produced 'antigen paralysis' in experimental allergic encephalomyelitis mice. DESIGN: Fifty patients were randomly selected without controls. They were assessed clinically at entry and on four other occasions over 14 months...
September 1996: Canadian Journal of Infectious Diseases, Journal Canadien des Maladies Infectieuses
https://www.readbyqxmd.com/read/22328682/rising-prevalence-of-vascular-comorbidities-in-multiple-sclerosis-validation-of-administrative-definitions-for-diabetes-hypertension-and-hyperlipidemia
#17
Ruth Ann Marrie, Bo Nancy Yu, Stella Leung, Lawrence Elliott, Patricia Caetano, Sharon Warren, Christina Wolfson, Scott B Patten, Lawrence W Svenson, Helen Tremlett, John Fisk, James F Blanchard
BACKGROUND: Despite the importance of comorbidity in multiple sclerosis (MS), methods for comorbidity assessment in MS are poorly developed. OBJECTIVE: We validated and applied administrative case definitions for diabetes, hypertension, and hyperlipidemia in MS. METHODS: Using provincial administrative data we identified persons with MS and a matched general population cohort. Case definitions for diabetes, hypertension, and hyperlipidemia were derived using hospital, physician, and prescription claims, and validated in 430 persons with MS...
September 2012: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/20551692/validation-of-a-self-report-comorbidity-questionnaire-for-multiple-sclerosis
#18
Myles Horton, Richard A Rudick, Claire Hara-Cleaver, Ruth Ann Marrie
BACKGROUND/AIMS: Researchers increasingly recognize the high frequency of comorbidity in multiple sclerosis (MS) and the negative impact on quality of life and disability, but little work has evaluated methods of comorbidity measurement in MS. We aimed to validate a self-report questionnaire for assessing comorbidity in MS. METHODS: Patients with MS were recruited from the MS Clinic in Winnipeg, Canada and the Mellen Center (Cleveland Clinic, Cleveland, Ohio, USA) from October 2008 to 2009...
August 2010: Neuroepidemiology
https://www.readbyqxmd.com/read/20071664/the-rising-prevalence-and-changing-age-distribution-of-multiple-sclerosis-in-manitoba
#19
R A Marrie, N Yu, J Blanchard, S Leung, L Elliott
OBJECTIVE: Several studies suggest an increasing prevalence of multiple sclerosis (MS) in Canada. We aimed to validate a case definition for MS using administrative health insurance data, and to describe the incidence and prevalence of MS in Manitoba, Canada. METHODS: We used provincial administrative claims data to identify persons with demyelinating disease using International Classification of Diseases 9/10 codes and prescription claims. To validate the case definition, questionnaires were mailed to 2,000 randomly selected persons with an encounter for demyelinating disease, requesting permission for medical records review...
February 9, 2010: Neurology
https://www.readbyqxmd.com/read/17598594/prevalence-of-multiple-sclerosis-in-first-nations-people-of-alberta
#20
Lawrence W Svenson, Sharon Warren, Kenneth G Warren, Luanne M Metz, Scott B Patten, Donald P Schopflocher
BACKGROUND: Multiple Sclerosis (MS) is reported to be uncommon among North American aboriginals despite frequent intermarriage with people of European ancestry, but few population-based studies have been conducted. The purpose of this study was to determine the prevalence of MS among First Nations aboriginal people in Alberta, Canada compared to the general population. METHODS: All hospital in-patient and physician fee-for-service records between 1994 and 2002 where a diagnosis of MS was mentioned were extracted from government health databases in the province of Alberta...
May 2007: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
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