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https://www.readbyqxmd.com/read/28987876/synthesis-and-cholinesterase-inhibitory-activity-study-of-new-piperidone-grafted-spiropyrrolidines
#1
Alireza Basiri, Basma M Abd Razik, Mohammed Oday Ezzat, Yalda Kia, Raju Suresh Kumar, Abdulrahman I Almansour, Natarajan Arumugam, Vikneswaran Murugaiyah
Alzheimer's disease (AD) is a prevalent neurodegenerative disorder, which affected 35 million people in the world. The most practiced approach to improve the life expectancy of AD patients is to increase acetylcholine neurotransmitter level at cholinergic synapses by inhibition of cholinesterase enzymes. A series of unreported piperidone grafted spiropyrrolidines 8(a-p) were synthesized and evaluated in vitro for their acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activities. Therein, compounds 8h and 8l displayed more potent AChE enzyme inhibition than standard drug with IC50 values of 1...
September 29, 2017: Bioorganic Chemistry
https://www.readbyqxmd.com/read/28918978/editorial
#2
EDITORIAL
Caroline Hing, Oday Al-Dahah
No abstract text is available yet for this article.
October 2017: Knee
https://www.readbyqxmd.com/read/28916371/ramucirumab-plus-docetaxel-versus-placebo-plus-docetaxel-in-patients-with-locally-advanced-or-metastatic-urothelial-carcinoma-after-platinum-based-therapy-range-a-randomised-double-blind-phase-3-trial
#3
Daniel P Petrylak, Ronald de Wit, Kim N Chi, Alexandra Drakaki, Cora N Sternberg, Hiroyuki Nishiyama, Daniel Castellano, Syed Hussain, Aude Fléchon, Aristotelis Bamias, Evan Y Yu, Michiel S van der Heijden, Nobuaki Matsubara, Boris Alekseev, Andrea Necchi, Lajos Géczi, Yen-Chuan Ou, Hasan Senol Coskun, Wen-Pin Su, Miriam Hegemann, Ivor J Percent, Jae-Lyun Lee, Marcello Tucci, Andrey Semenov, Fredrik Laestadius, Avivit Peer, Giampaolo Tortora, Sufia Safina, Xavier Garcia Del Muro, Alejo Rodriguez-Vida, Irfan Cicin, Hakan Harputluoglu, Ryan C Widau, Astra M Liepa, Richard A Walgren, Oday Hamid, Annamaria H Zimmermann, Katherine M Bell-McGuinn, Thomas Powles
BACKGROUND: Few treatments with a distinct mechanism of action are available for patients with platinum-refractory advanced or metastatic urothelial carcinoma. We assessed the efficacy and safety of treatment with docetaxel plus either ramucirumab-a human IgG1 VEGFR-2 antagonist-or placebo in this patient population. METHODS: We did a randomised, double-blind, phase 3 trial in patients with advanced or metastatic urothelial carcinoma who progressed during or after platinum-based chemotherapy...
September 12, 2017: Lancet
https://www.readbyqxmd.com/read/28807224/mesua-ferrea-stem-bark-extract-induces-apoptosis-and-inhibits-metastasis-in-human-colorectal-carcinoma-hct-116-cells-through-modulation-of-multiple-cell-signalling-pathways
#4
Muhammad Asif, Armaghan Shafaei, Aman Shah Abdul Majid, Mohammed Oday Ezzat, Saad S Dahham, Mohamed B Khadeer Ahamed, Chern Ein Oon, Amin Malik Shah Abdul Majid
Considering the great potential of natural products as anticancer agents, the present study was designed to explore the molecular mechanisms responsible for anticancer activities of Mesua ferrea stem bark extract against human colorectal carcinoma. Based on MTT assay results, bioactive sub-fraction (SF-3) was selected for further studies using HCT 116 cells. Repeated column chromatography resulted in isolation of less active α-amyrin from SF-3, which was identified and characterized by GC-MS and HPLC methods...
July 2017: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/28720917/exploring-electronic-communication-modes-between-iraqi-faculty-and-students-of-pharmacy-schools-using-the-technology-acceptance-model
#5
Ali Azeez Al-Jumaili, Mohammed D Al-Rekabi, Oday S Alsawad, Omer Q B Allela, Ryan Carnahan, Hiwa Saaed, Alaadin Naqishbandi, Dheyaa J Kadhim, Bernard Sorofman
Objective. To explore for the first time the extent to which Iraqi pharmacy students and faculty use Facebook and university email for academic communications, and to examine factors influencing utilization within the framework of the Technology Acceptance Model (TAM). Methods. An electronic survey was administered to convenience samples of students and faculty of six Iraqi public schools and colleges of pharmacy in 2015. Results. Responses included 489 student and 128 faculty usable surveys. Both students and faculty use Facebook more than university email for academic communications...
June 2017: American Journal of Pharmaceutical Education
https://www.readbyqxmd.com/read/28702910/a-novel-biocoagulant-agent-from-mushroom-chitosan-as-water-and-wastewater-therapy
#6
Oday Adnan, Zurina Z Abidin, Azni Idris, Suryani Kamarudin, Mothanna Sadiq Al-Qubaisi
A new commercial cationic polyelectrolyte chitosan (CM), obtained from the waste of mushroom production, was examined using models of water and wastewater namely kaolin and palm oil mill effluent (pome). As it is biocompatible, widely available, and economically feasible, chitosan mushroom has high potential to be a suitable replacement for alum. Also, it can be a promising alternative to chitosan obtained traditionally from Crustaceans due to its higher zeta potential and homogeneity based on the raw material required for its production...
July 12, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28678257/insulated-molecular-wires-inhibiting-orthogonal-contacts-in-metal-complex-based-molecular-junctions
#7
Oday A Al-Owaedi, Sören Bock, David C Milan, Marie-Christine Oerthel, Michael S Inkpen, Dmitry S Yufit, Alexandre N Sobolev, Nicholas J Long, Tim Albrecht, Simon J Higgins, Martin R Bryce, Richard J Nichols, Colin J Lambert, Paul J Low
Metal complexes are receiving increased attention as molecular wires in fundamental studies of the transport properties of metal|molecule|metal junctions. In this context we report the single-molecule conductance of a systematic series of d(8) square-planar platinum(ii) trans-bis(alkynyl) complexes with terminal trimethylsilylethynyl (C[triple bond, length as m-dash]CSiMe3) contacting groups, e.g. trans-Pt{C[triple bond, length as m-dash]CC6H4C[triple bond, length as m-dash]CSiMe3}2(PR3)2 (R = Ph or Et), using a combination of scanning tunneling microscopy (STM) experiments in solution and theoretical calculations using density functional theory and non-equilibrium Green's function formalism...
July 20, 2017: Nanoscale
https://www.readbyqxmd.com/read/28589492/a-phase-1-study-of-ly2874455-an-oral-selective-pan-fgfr-inhibitor-in-patients-with-advanced-cancer
#8
Michael Michael, Yung-Jue Bang, Young Suk Park, Yoon-Koo Kang, Tae Min Kim, Oday Hamid, Donald Thornton, Sonya C Tate, Eyas Raddad, Jeanne Tie
BACKGROUND: We report here a phase 1 study of LY2874455, a potent oral selective pan-fibroblast growth factor receptor (FGFR) inhibitor. OBJECTIVE: The primary objective was to determine the recommended phase 2 dosing (RP2D). Secondary objectives included determining toxicity, antitumor activity, pharmacokinetics (PK), and pharmacodynamic (PD) properties of LY2874455. PATIENTS AND METHODS: This study comprised two parts: (a) dose escalation with 3 + 3 cohorts in patients with solid tumors and (b) dose-expansion cohorts in patients with gastric cancer (GC) and non-small cell lung cancer (NSCLC)...
August 2017: Targeted Oncology
https://www.readbyqxmd.com/read/28540362/an-optimal-current-controller-design-for-a-grid-connected-inverter-to-improve-power-quality-and-test-commercial-pv-inverters
#9
Ali Algaddafi, Saud A Altuwayjiri, Oday A Ahmed, Ibrahim Daho
Grid connected inverters play a crucial role in generating energy to be fed to the grid. A filter is commonly used to suppress the switching frequency harmonics produced by the inverter, this being passive, and either an L- or LCL-filter. The latter is smaller in size compared to the L-filter. But choosing the optimal values of the LCL-filter is challenging due to resonance, which can affect stability. This paper presents a simple inverter controller design with an L-filter. The control topology is simple and applied easily using traditional control theory...
2017: TheScientificWorldJournal
https://www.readbyqxmd.com/read/28458941/intestinal-obstruction-in-a-patient-with-sclerosing-encapsulating-peritonitis
#10
Oday Obaid, Dawood Alhalabi, Mohamed Ghonami
Sclerosing encapsulating peritonitis (SEP) is a rare disorder that is characterized by encapsulation of bowel loops by thick fibrinogenous case. Most patients present with vague abdominal symptoms. It is challenging to diagnose the condition preoperatively. Surgical management is preserved for patients with small bowel obstruction with no improvement on conservative measures or for those with signs of bowel ischemia (Li et al., 2014; Habib et al. 2011). Herein, we discuss the clinical signs and symptoms, the radiological features, the surgical management, and outcome of SEP based on a patient who underwent surgery in our hospital...
2017: Case Reports in Surgery
https://www.readbyqxmd.com/read/28393855/enhanced-terahertz-radiation-generation-of-photoconductive-antennas-based-on-manganese-ferrite-nanoparticles
#11
Weien Lai, Oday Mazin Abdulmunem, Pablo Del Pino, Beatriz Pelaz, Wolfgang J Parak, Qian Zhang, Huaiwu Zhang
This paper presents a significant effect of manganese ferrite nanoparticles (MnFe2O4 NPs) on the increase of the surface photoconductivity of semiconductors. Herein, the optical characterization of photo-excited carriers of silicon coated with MnFe2O4 NPs was studied by using THz time-domain spectroscopy (THz-TDs). We observed that silicon coated with MnFe2O4 NPs provided a significantly enhanced attenuation of THz radiation in comparison with bare silicon substrates under laser irradiation. The experimental results were assessed in the context of a surface band structure model of semiconductors...
April 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28236984/a-randomized-phase-ii-study-of-ly2510924-and-carboplatin-etoposide-versus-carboplatin-etoposide-in-extensive-disease-small-cell-lung-cancer
#12
RANDOMIZED CONTROLLED TRIAL
Ravi Salgia, John R Stille, R Waide Weaver, Michael McCleod, Oday Hamid, John Polzer, Stephanie Roberson, Amy Flynt, David R Spigel
OBJECTIVES: This multicenter, open-label, randomized phase II study evaluated the efficacy and safety of LY2510924 (LY) added to first-line standard of care (SOC) chemotherapy for extensive-disease small cell lung cancer (ED-SCLC) and explored the predictive value of C-X-C motif receptor 4 (CXCR4) tumor response. MATERIALS AND METHODS: Patients with treatment-naïve ED-SCLC were randomized (1:1) to receive up to six 21-day cycles of carboplatin/etoposide alone (SOC) or in combination with 20mg LY2510924 administered subcutaneously on days 1-7 of each cycle (LY+SOC)...
March 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/28164858/editorial
#13
EDITORIAL
Caroline Hing, Oday Al-Dadah
No abstract text is available yet for this article.
January 2017: Knee
https://www.readbyqxmd.com/read/27919322/editorial
#14
EDITORIAL
Oday Al-Dadah, Caroline Hing
No abstract text is available yet for this article.
December 2016: Knee
https://www.readbyqxmd.com/read/27897344/single-molecule-conductance-studies-of-organometallic-complexes-bearing-3-thienyl-contacting-groups
#15
Sören Bock, Oday A Al-Owaedi, Samantha G Eaves, David C Milan, Mario Lemmer, Brian W Skelton, Henrry M Osorio, Richard J Nichols, Simon J Higgins, Pilar Cea, Nicholas J Long, Tim Albrecht, Santiago Martín, Colin J Lambert, Paul J Low
The compounds and complexes 1,4-C6 H4 (C≡C-cyclo-3-C4 H3 S)2 (2), trans-[Pt(C≡C-cyclo-3-C4 H3 S)2 (PEt3 )2 ] (3), trans-[Ru(C≡C-cyclo-3-C4 H3 S)2 (dppe)2 ] (4; dppe=1,2-bis(diphenylphosphino)ethane) and trans-[Ru(C≡C-cyclo-3-C4 H3 S)2 {P(OEt)3 }4 ] (5) featuring the 3-thienyl moiety as a surface contacting group for gold electrodes have been prepared, crystallographically characterised in the case of 3-5 and studied in metal|molecule|metal junctions by using both scanning tunnelling microscope break-junction (STM-BJ) and STM-I(s) methods (measuring the tunnelling current (I) as a function of distance (s))...
February 10, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/27829926/palladium-catalyzed-ring-opening-reactions-of-cyclopropanated-7-oxabenzonorbornadiene-with-alcohols
#16
Katrina Tait, Oday Alrifai, Rebecca Boutin, Jamie Haner, William Tam
Palladium-catalyzed ring-opening reactions of cyclopropanated 7-oxabenzonorbornadiene derivatives using alcohol nucleophiles were investigated. The optimal conditions were found to be 10 mol % PdCl2(CH3CN)2 in methanol, offering yields up to 92%. The reaction was successful using primary, secondary and tertiary alcohol nucleophiles and was compatible with a variety of substituents on cyclopropanated oxabenzonorbornadiene. With unsymmetrical C1-substituted cyclopropanated 7-oxabenzonorbornadienes, the regioselectivity of the reaction was excellent, forming only one regioisomer in all cases...
2016: Beilstein Journal of Organic Chemistry
https://www.readbyqxmd.com/read/27811572/complications-in-placement-of-a-glaucoma-drainage-device-in-a-patient-with-crest-syndrome
#17
Maria Q Husain, Oday Alsheikh
This case describes difficulty with conjunctival closure in an 80-year-old woman with CREST syndrome, a subset of systemic scleroderma. The patient underwent uneventful glaucoma drainage device implantation, but friability of the conjunctiva was noted during closure. Amniotic membrane was used to ensure secure closure, and the patient had a successful outcome. There is a paucity of existing studies on patients with CREST syndrome and their ocular findings. This report sheds light on ocular findings in this autoimmune disease and the necessity for alternative closure methods in special cases...
February 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/27487647/anesthesia-for-charcot-marie-tooth-disease-case-report
#18
Khalid R Alzaben, Omar Q Samarah, Salameh S Obeidat, Oday Halhouli, Murad Al Kharabsheh
Charcot-Marie-Tooth disease comprises a group of disorders characterized by progressive muscle weakness and wasting. Reviewing the anaesthetic literature produced conflicting reports about the best anaesthetic options for patients with CMTD; as they are at increased risk of prolonged response to muscle relaxants, malignant hyperthermia and risks of regional anaesthesia. We present a case of the successful use of total intravenous anaesthesia with dexmedetomidine and propofol combined with caudal block using bupivacaine mixed with dexmedetomidine without any complications, for a 17 year old male patient with Charcot Marie-Tooth disease who underwent a lower limb orthopedic surgery...
June 2016: Middle East Journal of Anesthesiology
https://www.readbyqxmd.com/read/27473946/editorial
#19
EDITORIAL
Oday Al-Dadah, Caroline Hing
No abstract text is available yet for this article.
August 2016: Knee
https://www.readbyqxmd.com/read/27472889/synthesis-and-single-molecule-conductance-study-of-redox-active-ruthenium-complexes-with-pyridyl-and-dihydrobenzo-b-thiophene-anchoring-groups
#20
Hiroaki Ozawa, Masoud Baghernejad, Oday A Al-Owaedi, Veerabhadrarao Kaliginedi, Takumi Nagashima, Jaime Ferrer, Thomas Wandlowski, Víctor M García-Suárez, Peter Broekmann, Colin J Lambert, Masa-Aki Haga
The ancillary ligands 4'-(4-pyridyl)-2,2':6',2''-terpyridine and 4'-(2,3-dihydrobenzo[b]thiophene)-2,2'-6',2"-terpyridine were used to synthesize two series of mono- and dinuclear ruthenium complexes differing in their lengths and anchoring groups. The electrochemical and single-molecular conductance properties of these two series of ruthenium complexes were studied experimentally by means of cyclic voltammetry and the scanning tunneling microscopy-break junction technique (STM-BJ) and theoretically by means of density functional theory (DFT)...
August 26, 2016: Chemistry: a European Journal
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