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https://www.readbyqxmd.com/read/28346523/a-moderate-diet-restriction-during-pregnancy-alters-the-levels-of-endocannabinoids-and-endocannabinoid-related-lipids-in-the-hypothalamus-hippocampus-and-olfactory-bulb-of-rat-offspring-in-a-sex-specific-manner
#1
María Teresa Ramírez-López, Mariam Vázquez, Ermelinda Lomazzo, Clementine Hofmann, Rosario Noemi Blanco, Francisco Alén, María Antón, Juan Decara, Rocío Arco, Laura Orio, Juan Suárez, Beat Lutz, Raquel Gómez de Heras, Laura Bindila, Fernando Rodríguez de Fonseca
Undernutrition during pregnancy has been associated to increased vulnerability to develop metabolic and behavior alterations later in life. The endocannabinoid system might play an important role in these processes. Therefore, we investigated the effects of a moderate maternal calorie-restricted diet on the levels of the endocannabinoid 2-arachidonoyl glycerol (2-AG), arachidonic acid (AA) and the N-acylethanolamines (NAEs) anandamide (AEA), oleoylethanolamide (OEA) and palmitoylethanolamide (PEA) in the brain of newborn rat offspring...
2017: PloS One
https://www.readbyqxmd.com/read/28346496/overlapping-setbp1-gain-of-function-mutations-in-schinzel-giedion-syndrome-and-hematologic-malignancies
#2
Rocio Acuna-Hidalgo, Pelagia Deriziotis, Marloes Steehouwer, Christian Gilissen, Sarah A Graham, Sipko van Dam, Julie Hoover-Fong, Aida B Telegrafi, Anne Destree, Robert Smigiel, Lindsday A Lambie, Hülya Kayserili, Umut Altunoglu, Elisabetta Lapi, Maria Luisa Uzielli, Mariana Aracena, Banu G Nur, Ercan Mihci, Lilia M A Moreira, Viviane Borges Ferreira, Dafne D G Horovitz, Katia M da Rocha, Aleksandra Jezela-Stanek, Alice S Brooks, Heiko Reutter, Julie S Cohen, Ali Fatemi, Martin Smitka, Theresa A Grebe, Nataliya Di Donato, Charu Deshpande, Anthony Vandersteen, Charles Marques Lourenço, Andreas Dufke, Eva Rossier, Gwenaelle Andre, Alessandra Baumer, Careni Spencer, Julie McGaughran, Lude Franke, Joris A Veltman, Bert B A De Vries, Albert Schinzel, Simon E Fisher, Alexander Hoischen, Bregje W van Bon
Schinzel-Giedion syndrome (SGS) is a rare developmental disorder characterized by multiple malformations, severe neurological alterations and increased risk of malignancy. SGS is caused by de novo germline mutations clustering to a 12bp hotspot in exon 4 of SETBP1. Mutations in this hotspot disrupt a degron, a signal for the regulation of protein degradation, and lead to the accumulation of SETBP1 protein. Overlapping SETBP1 hotspot mutations have been observed recurrently as somatic events in leukemia. We collected clinical information of 47 SGS patients (including 26 novel cases) with germline SETBP1 mutations and of four individuals with a milder phenotype caused by de novo germline mutations adjacent to the SETBP1 hotspot...
March 27, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28345344/unravelling-and-quantifying-the-nmr-invisible-metabolites-interacting-with-human-serum-albumin-by-binding-competition-and-t2-relaxation-based-decomposition-analysis
#3
Ruben Barrilero, Noelia Ramirez, Joan Carles Vallvé, Delia Taverner, Rocío Fuertes, Núria Amigó, Xavier Correig
Quantitative profiling of low-molecular-weight metabolites (LMWM) by 1H-NMR is routinely used in high-throughput serum metabolomics. First, the protein background is attenuated using a T2 filter, then the LMWM signals are resolved by line-shape fitting. However, protein binding modifies the motional properties of LMWM and their signal partially attenuates with the T2 filter, along with the protein background. Consequently, the quantified LMWM signal does not reflect the total concentration in serum but the non-binding part...
March 27, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28343890/glycine-receptor-subunits-expression-in-the-developing-rat-retina
#4
Gustavo Sánchez-Chávez, Miguel Ángel Velázquez-Flores, Ruth Ruiz Esparza-Garrido, Rocío Salceda
BACKGROUND AND METHODS: Glycine receptor (GlyR) consists of two α (1-4) and three β subunits. Considerable evidence indicates that the adult retina expresses the four types of α subunits; however, the proportion of these subunits in adult and immature retina is almost unknown. In this report we have studied mRNA and the protein expression of GlyR subunits in the retina during postnatal rat development by Real-Time qRT-PCR and western blot. RESULTS: mRNA and protein expression indicated a gradual increase of the α1, α3, α4 and β GlyR subunits during postnatal ages tested...
March 23, 2017: Neurochemistry International
https://www.readbyqxmd.com/read/28343858/-inhibitory-capacity-of-lactobacillus-spp-against-pathogens-involved-in-foodborne-diseases
#5
María J Ruiz, Rocío Colello, Nora L Padola, Analía I Etcheverría
The genus Lactobacillus daily generates a growing interest among microbiologists and technologists, who try to discover new biotechnological applications and probiotic properties. The main goal of this study was to evaluate the inhibitory capacity of Lactobacillus spp. against pathogens (Escherichia coli O157:H7, Salmonella spp., Staphylococcus aureus) involved in foodborne diseases. For this purpose, samples were collected at different stages of the pork production chain. Seventy eight bacterial strains were isolated...
March 23, 2017: Revista Argentina de Microbiología
https://www.readbyqxmd.com/read/28343738/short-term-association-between-road-traffic-noise-and-healthcare-demand-generated-by-parkinson-s-disease-in-madrid-spain
#6
Julio Díaz, Pablo Martínez-Martín, Carmen Rodríguez-Blázquez, Blanca Vázquez, Maria João Forjaz, Cristina Ortiz, Rocío Carmona, Cristina Linares
OBJECTIVE: To analyse whether there is a short-term association between road traffic noise in the city of Madrid and Parkinson's disease (PD)-related demand for healthcare. METHODS: Time-series analysis (2008-2009) using variables of analysis linked to emergency and daily PD-related demand for healthcare (ICD-10: G20-G21), namely, PD-hospital admissions (HAs), PD-outpatient visits (OVs) and PD-emergency medical calls in Madrid. The noise pollution measurements used were Leqd, equivalent sound level for the daytime hours (from 8 a...
March 23, 2017: Gaceta Sanitaria
https://www.readbyqxmd.com/read/28341432/development-validation-and-evaluation-of-an-analytical-method-for-the-determination-of-monomeric-and-oligomeric-procyanidins-in-apple-extracts
#7
Wendy J Hollands, Stefan Voorspoels, Griet Jacobs, Kjersti Aaby, Ane Meisland, Rocio Garcia-Villalba, Francisco Tomas-Barberan, Mariusz K Piskula, Deborah Mawson, Irena Vovk, Paul W Needs, Paul A Kroon
There is a lack of data for individual oligomeric procyanidins in apples and apple extracts. Our aim was to develop, validate and evaluate an analytical method for the separation, identification and quantification of monomeric and oligomeric flavanols in apple extracts. To achieve this, we prepared two types of flavanol extracts from freeze-dried apples; one was an epicatechin-rich extract containing ∼30% (w/w) monomeric (-)-epicatechin which also contained oligomeric procyanidins (Extract A), the second was an oligomeric procyanidin-rich extract depleted of epicatechin (Extract B)...
March 18, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28338787/total-and-fetal-circulating-cell-free-dna-angiogenic-and-antiangiogenic-factors-in-preeclampsia-and-hellp-syndrome
#8
Rocío Muñoz-Hernández, Pablo Medrano-Campillo, Maria L Miranda, Hada C Macher, Jose Manuel Praena-Fernández, Antonio J Vallejo-Vaz, María J Dominguez-Simeon, Rafael Moreno-Luna, Pablo Stiefel
BACKGROUND: Preeclampsia (PE) is a hypertensive disorder of pregnancy characterized by hypertension and proteinuria. The HELLP syndrome is the most severe form of PE. The aim of the present study was to determine different potential biomarkers that may help us perform an early diagnosis of the disease, assess on the severity of the disease, and/or predict maternal or fetal adverse outcomes. METHODS: We measured serum levels of total and fetal circulating cell-free DNA (cfDNA), soluble endoglin, soluble form of vascular endothelial growth factor receptor, and placental growth factor in a healthy control group of pregnant women (n = 26), patients with mild (n = 37) and severe PE (n = 25), and patients with HELLP syndrome (n = 16)...
February 25, 2017: American Journal of Hypertension
https://www.readbyqxmd.com/read/28337609/trans-eyebrow-supraorbital-approach-in-large-suprasellar-craniopharyngioma-surgery-in-adults-analysis-of-optic-nerve-length-and-extent-of-tumor-resection-original-article
#9
Ricardo Prat, Inma Galeano, Rocío Evangelista, Giovanni Pancucci, Juliana Guarín, Angel Ayuso, Mukesh Misra
BACKGROUND: One of the main drawbacks in the surgery of large craniopharyngiomas is the presence of a prefixed optic chiasm. Our main objective in this study is to compare the predictive value of the optic nerve length and optic chiasm location on large craniopharyngiomas' extent of resection. METHOD: We retrospectively studied 21 consecutive patients with large craniopharyngiomas who underwent tumor resection through the trans-eyebrow supraorbital approach. Clinical and radiological findings on preoperative MRI were recorded, including the optic chiasm location classified as prefixed, postfixed or normal...
March 23, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28337047/enhancing-parenting-practices-with-latino-a-immigrants-integrating-evidence-based-knowledge-and-culture-according-to-the-voices-of-latino-a-parents
#10
J Rubén Parra-Cardona, Gabriela López Zerón, Monica Villa, Efraín Zamudio, Ana Rocío Escobar-Chew, Melanie M Domenech Rodríguez
No abstract text is available yet for this article.
March 2017: Clinical Social Work Journal
https://www.readbyqxmd.com/read/28336678/neutrophils-regulate-the-lung-inflammatory-response-via-%C3%AE-%C3%AE-t-cell-infiltration-in-an-experimental-mouse-model-of-human-metapneumovirus-infection
#11
Nagarjuna R Cheemarla, Ma Del Rocío Baños-Lara, Shan Naidu, Antonieta Guerrero-Plata
Neutrophils are the most abundant leukocytes in human circulation. They are the first immune cell population recruited to the sites of infection. However, the role of neutrophils to regulate host immune responses during respiratory viral infections is largely unknown. To elucidate the role of neutrophils in respiratory antiviral defense, we used an experimental mouse model of human metapneumovirus (HMPV) infection. HMPV, a member of the Paramyxoviridae family, is a leading respiratory pathogen causing severe symptoms, such as bronchiolitis and pneumonia, in young, elderly, and immunocompromised patients...
March 23, 2017: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/28336351/proposed-medicare-coverage-for-diabetes-prevention-strengths-limitations-and-recommendations-for-improvement
#12
Natalie D Ritchie, Edward P Havranek, Susan L Moore, Rocio I Pereira
No abstract text is available yet for this article.
March 20, 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28336302/-vasopressors-and-inotropes-use-in-pediatrics
#13
Adrián García-Canales, Rocío Alejandra Peña-Juárez, Luz de María Sandoval-Franco
The cardiovascular system is a dynamic system whose function is to ensure adequate delivery of oxygen, nutrients and hormones to the tissues, necessary for cell metabolism, also synthesizes and modifies vasoactive components to regulate vascular tone and myocardial function. These components have become critical in the management of pediatric patients in critical condition with heart failure and shock which has proven its beneficial effects, however its use and abuse brings harmful effects, increase mortality, associated with arrhythmias and increase myocardial oxygen consumption favoring the presence of ischemia, therefore is necessary to know the mechanism of action and indications of these drugs to minimize the harmful effects...
March 20, 2017: Archivos de Cardiología de México
https://www.readbyqxmd.com/read/28332874/long-term-outcome-of-the-different-treatment-alternatives-for-recurrent-and-persistent-cushing-s-disease
#14
Ana Laura Espinosa-de-Los-Monteros, Ernesto Sosa-Eroza, Etual Espinosa, Victoria Mendoza, Rocio Arreola, Moises Mercado
BACKGROUND: Treatment alternatives for persistent and recurrent Cushing's disease (CD) include pituitary surgical reintervention, radiotherapy, pharmacotherapy and bilateral adrenalectomy (BA). The decision of which of these alternatives is better suited for the individual patient rests on clinical judgment and the availability of resources. OBJECTIVE: To evaluate the long-term efficacy of the different secondary interventions for persistent and recurrent Cushing's disease...
March 23, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28332076/erratum-to-evaluation-of-vitamin-and-trace-element-requirements-after-sleeve-gastrectomy-at-long-term
#15
Silvia Pellitero, Eva Martínez, Rocío Puig, Alba Leis, Roxanna Zavala, María Luisa Granada, Cruz Pastor, Pau Moreno, Jordi Tarascó, Jose Balibrea, Manel Puig-Domingo
No abstract text is available yet for this article.
March 22, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28331215/description-of-a-strong-relationship-among-total-cell-free-dna-levels-ldh-values-ast-values-and-platelet-count-in-patients-with-hellp-syndrome
#16
Pablo Stiefel, María L Miranda, Hada Macher, Luis M Beltran-Romero, Rocio Muñoz-Hernandez
No abstract text is available yet for this article.
March 23, 2017: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/28330818/cardio-onco-hematology-in-clinical-practice-position-paper-and-recommendations
#17
Teresa López-Fernández, Ana Martín García, Ana Santaballa Beltrán, Ángel Montero Luis, Ramón García Sanz, Pilar Mazón Ramos, Sonia Velasco Del Castillo, Esteban López de Sá Areses, Manuel Barreiro-Pérez, Rocío Hinojar Baydes, Leopoldo Pérez de Isla, Silvia Cayetana Valbuena López, Regina Dalmau González-Gallarza, Francisco Calvo-Iglesias, Juan José González Ferrer, Antonio Castro Fernández, Eva González-Caballero, Cristina Mitroi, Meritxell Arenas, Juan Antonio Virizuela Echaburu, Pascual Marco Vera, Andrés Íñiguez Romo, José Luis Zamorano, Juan Carlos Plana Gómez, José Luis López Sendón Henchel
Improvements in early detection and treatment have markedly reduced cancer-related mortality. However survival not only depends on effectively cure cancer, but prevention, diagnosis and treatment of cancer-related complications is also needed. Cardiovascular toxicity is a widespread problem across many classes of therapeutic schemes, however scientific evidence in the management of cardiovascular complications of onco-hematological patients is scarce, as these patients have been systematically excluded from clinical trials and current recommendations are based on expert consensus...
March 18, 2017: Revista Española de Cardiología
https://www.readbyqxmd.com/read/28327839/-sociocultural-factors-determinants-of-eating-habits-of-kindergarten-schoolchildren-in-peru
#18
Rocío González-Jiménez, Fátima León-Larios, Mercedes Lomas-Campos, María-Jesús Albar
To examine the sociocultural factors that determine the eating habits of children aged less than 5 years who attend kindergarten school in Chachapoyas in Peru, we carried out a qualitative study by means of semi-structured interviews of 18 fathers and mothers. The key factors related to eating habits were as follows: availability and easiness to prepare foods, schedule and work done by parents, intake of coffee in children as a common practice, lack of resources and economic uncertainty for food planning, and the lack of nutritional knowledge...
October 2016: Revista Peruana de Medicina Experimental y Salud Pública
https://www.readbyqxmd.com/read/28322000/postprandial-triglyceride-rich-lipoproteins-promote-lipid-accumulation-and-apolipoprotein-b-48-receptor-transcriptional-activity-in-human-circulating-and-murine-bone-marrow-neutrophils-in-a-fatty-acid-dependent-manner
#19
Almudena Ortega-Gómez, Lourdes M Varela, Sergio Lopez, Sergio Montserrat de la Paz, Rosario Sanchez, Francisco J G Muriana, Beatriz Bermúdez, Rocío Abia
SCOPE: Postprandial triglyceride-rich lipoproteins (TRLs) promote atherosclerosis. Recent research points the bone marrow (BM) as a primary site in atherosclerosis. We elucidated how the acute administration of MUFAs, omega-3 PUFAs and saturated fatty acids (SFAs) affects human circulating and murine BM neutrophil lipid accumulation and functionality. METHODS AND RESULTS: Postprandial hypertriglyceridemia was induced in healthy subjects and Apoe-/- mice by the acute administration of dietary fats enriched in MUFAs, PUFAs or SFAs...
March 21, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28321850/educational-intervention-about-oral-piercing-knowledge-among-dental-students-and-adolescents-at-schools
#20
Pilar Junco, Rocío Barrios, María José Ruiz, Manuel Bravo
INTRODUCTION: Oral piercing can lead to complications and dentists are in a unique position to detect such complications. The purpose of this study was: (i) to assess the immediate and the long-term effects, on dental students, of a training programme about oral piercing knowledge; and (ii) to assess the immediate effect, on adolescents, of a single educational intervention session about oral piercing. METHODS: A training programme for dental students (n = 66) was carried out in three phases...
March 20, 2017: International Dental Journal
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