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https://www.readbyqxmd.com/read/28644773/mobilized-peripheral-blood-stem-cells-versus-unstimulated-bone-marrow-as-a-graft-source-for-t-cell-replete-haploidentical-donor-transplantation-using-post-transplant-cyclophosphamide
#1
Asad Bashey, Mei-Jie Zhang, Shannon R McCurdy, Andrew St Martin, Trevor Argall, Claudio Anasetti, Stefan O Ciurea, Omotayo Fasan, Sameh Gaballa, Mehdi Hamadani, Pashna Munshi, Monzr M Al Malki, Ryotaro Nakamura, Paul V O'Donnell, Miguel-Angel Perales, Kavita Raj, Rizwan Romee, Scott Rowley, Vanderson Rocha, Rachel B Salit, Melhem Solh, Robert J Soiffer, Ephraim Joseph Fuchs, Mary Eapen
Purpose T-cell-replete HLA-haploidentical donor hematopoietic transplantation using post-transplant cyclophosphamide was originally described using bone marrow (BM). With increasing use of mobilized peripheral blood (PB), we compared transplant outcomes after PB and BM transplants. Patients and Methods A total of 681 patients with hematologic malignancy who underwent transplantation in the United States between 2009 and 2014 received BM (n = 481) or PB (n = 190) grafts. Cox regression models were built to examine differences in transplant outcomes by graft type, adjusting for patient, disease, and transplant characteristics...
June 23, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28638232/epidemiology-of-functional-gastrointestinal-disorders-in-children-and-adolescents-a-systematic-review
#2
Alexandre Canon Boronat, Ana Paula Ferreira-Maia, Alicia Matijasevich, Yuan-Pang Wang
AIM: To assess the prevalence of functional gastrointestinal disorders (FGIDs) in children and adolescents. METHODS: PubMed, EMBASE, and Scopus databases were searched for original articles from inception to September 2016. The literature search was made in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) recommendations. For inclusion, each study had to report epidemiological data on FGIDs in children between 4 and 18 years old and contain standardized outcome based on Rome II, III or IV criteria...
June 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28634136/tongxie-formula-reduces-symptoms-of-irritable-bowel-syndrome
#3
Heng Fan, Liang Zheng, Yaoliang Lai, Weimin Lu, Zhixiang Yan, Qi Xiao, Baiwen Li, Min Tang, Dawei Huang, Yuanyuan Wang, Zhen Li, Yuwei Mei, Zhengyan Jiang, Xingxing Liu, Qing Tang, Dongmei Zuo, Jingyi Ye, Yongqiang Yang, Huisuo Huang, Zongxiang Tang, Jun Xiao
BACKGROUND & AIMS: Irritable bowel syndrome (IBS) is the most common chronic gastrointestinal disorder, yet few drugs are effective in reducing symptoms. Approximately 50% of patients with IBS attempt herbal therapy at least once. We performed a randomized controlled trial to compare the efficacy of the herb formulation tongxie vs placebo or pinaverium (an antispasmodic agent) in reducing symptoms of IBS. METHODS: We performed a trial of 1044 adult patients with IBS (based on Rome III criteria) at 5 hospitals in China, from August 2012 through January 2015...
June 17, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28632149/association-between-air-pollution-and-emergency-room-visits-for-atrial-fibrillation
#4
Angelo G Solimini, Matteo Renzi
Despite the large prevalence in the population, possible factors responsible for the induction of atrial fibrillation (AF) events in susceptible individuals remain incompletely understood. We investigated the association between air pollution levels and emergency department admissions for AF in Rome. We conducted a 14 years' time-series study to evaluate the association between the daily levels of air pollution (particulate matter, PM10 and PM2.5, and nitrogen dioxide, NO₂) and the daily count of emergency accesses for AF (ICD-9 code: 427...
June 20, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28629608/laparotomy-and-intraoperative-enteroscopy-for-obscure-gastrointestinal-bleeding-before-and-after-the-era-of-video-capsule-endoscopy-and-deep-enteroscopy-a-tertiary-center-experience
#5
Wuttiporn Manatsathit, Usah Khrucharoen, Dennis M Jensen, O Joe Hines, Thomas Kovacs, Gordon Ohning, Rome Jutabha, Kevin Ghassemi, Gareth S Dulai, Gustavo Machicado
BACKGROUND: To evaluate roles of intraoperative endoscopy (IOE) in management of severe obscure GI bleeding (OGIB) before vs. after introduction of video capsule endoscopy (VCE) and deep enteroscopy (DE). METHODS: We retrospectively reviewed prospectively collected data of patients undergoing IOE for severe OGIB in a tertiary referral center. RESULTS: 52 patients had laparotomy/IOE for OGIB, 11 pre and 41 post VCE/DE eras. In the pre VCE/DE era, 36...
June 16, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/28628918/bifidobacterium-rich-fecal-donor-may-be-a-positive-predictor-for-successful-fecal-microbiota-transplantation-in-patients-with-irritable-bowel-syndrome
#6
Shinta Mizuno, Tatsuhiro Masaoka, Makoto Naganuma, Taishiro Kishimoto, Momoko Kitazawa, Shunya Kurokawa, Moeko Nakashima, Kozue Takeshita, Wataru Suda, Masaru Mimura, Masahira Hattori, Takanori Kanai
BACKGROUND/AIMS: Dysbiosis is associated with various systemic disorders including irritable bowel syndrome (IBS). Fecal microbiota transplantation (FMT) might restore intestinal microbial balance. The study aimed to determine the safety and efficacy of FMT in IBS patients, as well as also positive predictors for FMT. METHODS: This was a single-arm, open-label study. Eligible patients were diagnosed based on Rome III Diagnostic Criteria. Fecal materials were administered to the patient via colonoscopy...
June 21, 2017: Digestion
https://www.readbyqxmd.com/read/28625832/diet-low-in-fodmaps-reduces-symptoms-in-patients-with-irritable-bowel-syndrome-and-probiotic-restores-bifidobacterium-species-a-randomized-controlled-trial
#7
H M Staudacher, M C E Lomer, F M Farquharson, P Louis, F Fava, E Franciosi, M Scholz, K M Tuohy, J O Lindsay, P M Irving, K Whelan
BACKGROUND & AIMS: Dietary restriction of fermentable carbohydrates (a low FODMAP diet) has been reported to reduce symptoms in some patients with irritable bowel syndrome (IBS). We performed a randomized, placebo-controlled study to determine its effects on symptoms and the fecal microbiota in patients with IBS. METHODS: We performed a 2x2 factorial trial of 104 patients with IBS (18-65 years old), based on the Rome III criteria, at 2 hospitals in the United Kingdom...
June 15, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28624984/the-senhance%C3%A2-surgical-robotic-system-senhance-for-total-hysterectomy-in-obese-patients-a-pilot-study
#8
Salvatore Gueli Alletti, C Rossitto, S Cianci, E Perrone, S Pizzacalla, G Monterossi, G Vizzielli, S Gidaro, G Scambia
This pilot study was aimed to value the feasibility and safety of Senhance Robotic Platform for hysterectomy in obese patients. Ten obese patients (30 < BMI < 40) underwent elective Senhance total extrafascial hysterectomy with bilateral salpingo-oophorectomy at the Division of Gynecologic Oncology of "Policlinico A. Gemelli" Foundation, Rome, Italy. Perioperative and postoperative outcomes data were recorded. The median age was 60 years (range 51-75) and the median BMI was 33.3 kg/m(2) (range 30...
June 17, 2017: Journal of Robotic Surgery
https://www.readbyqxmd.com/read/28609199/smoking-in-irritable-bowel-syndrome-a-systematic-review
#9
Laura Sirri, Silvana Grandi, Eliana Tossani
OBJECTIVE: The aim of this review was to examine (1) the prevalence of smoking in subjects with irritable bowel syndrome (IBS), (2) whether smoking prevalence significantly differs between subjects with and without IBS, and (3) whether smoking significantly predicts the presence or the development of IBS. METHODS: Articles were retrieved by systematically searching the Scopus, Web of Science, and PubMed electronic databases from inception to July 2016, using the keywords "smoking" and "tobacco" combined with "irritable bowel syndrome...
June 13, 2017: Journal of Dual Diagnosis
https://www.readbyqxmd.com/read/28589184/a-new-approach-in-bowel-preparation-before-colonoscopy-in-patients-with-constipation-a-prospective-randomized-investigator-blinded-trial
#10
Murat Yıldar, İsmail Yaman, Murat Başbuğ, Faruk Çavdar, Hasan Topfedaisi, Hayrullah Derici
OBJECTIVE: Enema administration in the morning of routine colonoscopy is known to be useless. However, the potential bowel cleansing effects of distal colon emptying with enema prior to purgatives are not known. The aim of this study is to investigate the effects of enema use before purgatives in preparation for colonoscopy. MATERIAL AND METHODS: Two hundred twenty-seven patients were randomly assigned into three groups; enema before purgative use, enema after purgative use, and no enema...
2017: Turk J Surg
https://www.readbyqxmd.com/read/28587796/effect-of-hospitalization-on-percent-median-body-mass-index-at-one%C3%A2-year-in-underweight-youth-with-restrictive-eating-disorders
#11
Cynthia J Kapphahn, Dionne A Graham, Elizabeth R Woods, Rebecca Hehn, Kathleen A Mammel, Sara F Forman, Martin Fisher, Kelly A Robinson, Ellen S Rome, Albert Hergenroeder, Neville H Golden
PURPOSE: Data from low-weight patients with restrictive eating disorders (EDs) treated in outpatient adolescent medicine-based ED treatment programs were analyzed to determine whether there was an association between hospitalization and gain to at least 90% median body mass index (mBMI) at 1-year follow-up. METHODS: Data were retrospectively collected for 322 low-weight (<85% mBMI at intake) patients aged 9-21 years, who presented with restrictive EDs to 14 adolescent medicine-based ED programs in 2010...
June 3, 2017: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/28577539/inguinal-and-anorectal-lymphogranuloma-venereum-a-case-series-from-a-sexually-transmitted-disease-center-in-rome-italy
#12
Alessandra Latini, Mauro Zaccarelli, Maria Grazia Paglia, Maria Gabriella Donà, Amalia Giglio, Domenico Moretto, Antonella Vulcano, Massimo Giuliani, Manuela Colafigli, Marina Ambrifi, Fulvia Pimpinelli, Antonio Cristaudo
BACKGROUND: Lymphogranuloma venereum (LGV) is a sexually transmitted infection caused by L1, L2, L3 serovars of C. trachomatis (CT). Since 2003, LGV cases have been increasing in Europe. Aim of this report is to describe the LGV cases diagnosed in the largest STI center in Rome, Italy, from 2000 to 2016. This report shows that two clinically and epidemiologically different series of cases exist, and that, at present, the ano-rectal LGV represents the clinical variant occurring more frequently among men having sex with men (MSM), particularly those HIV-infected...
June 2, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28566894/stress-and-sleep-quality-in-doctors-working-on-call-shifts-are-associated-with-functional-gastrointestinal-disorders
#13
Soo-Kyung Lim, Seung Jin Yoo, Dae Lim Koo, Chae A Park, Han Jun Ryu, Yong Jin Jung, Ji Bong Jeong, Byeong Gwan Kim, Kook Lae Lee, Seong-Joon Koh
AIM: To investigate the role of sleep quality and psychosocial problems as predictors of functional gastrointestinal disorders (FGIDs) in doctors that work 24 hour-on-call shifts. METHODS: In this cross-sectional observation study, using the Rome III Questionnaire and Pittsburgh Sleep Quality Index (PSQI), we analyzed 170 doctors with 24 hour-on-call shifts. RESULTS: Among the participants that had experienced a 24 hour-on-call shift within the last 6 mo, 48 (28...
May 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28562581/prevalence-and-risk-factors-of-chronic-constipation-among-women-aged-50-years-and-older-in-shanghai-china
#14
Ling Huang, Huihong Jiang, Maoling Zhu, Baocai Wang, Minsi Tong, Huaguang Li, Mou-Bin Lin, Li Li
BACKGROUND Chronic constipation (CC) is a major public health problem worldwide, especially in elderly women. This study aimed to investigate the prevalence and risk factors of CC among women aged 50 years and older in Shanghai, China. MATERIAL AND METHODS A cross-sectional survey was conducted on 1950 women aged 50 years and older, randomly sampled in Yangpu District of Shanghai from April to October 2015. Information on demographic characteristics, lifestyle habits, medical history, and defecation situation was collected through in-person interviews...
May 31, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28557834/preoperative-serum-human-epididymis-protein-4-levels-in-early-stage-endometrial-cancer-a-prospective-study
#15
Francesco Fanfani, Stefano Restaino, Stefania Cicogna, Marco Petrillo, Marcella Montico, Emanuele Perrone, Oriano Radillo, Rossella De Leo, Matteo Ceccarello, Giovanni Scambia, Giuseppe Ricci
OBJECTIVE: The aim of the study was to evaluate the prognostic value of human epididymis protein 4 (HE4) and cancer antigen 125 markers with pathological prognostic factor to complete the preoperative clinical panel and help the treatment planning. METHODS: This prospective multicenter study was conducted in 2 gynecologic oncology centers between 2012 and 2014 (Institute for Maternal and Child Health IRCCS Burlo Garofolo in Trieste and Catholic University of the Sacred Heart in Rome, Italy)...
May 26, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28541259/functional-gastrointestinal-disorders-in-children-a-survey-on-clinical-approach-in-the-mediterranean-area
#16
Elena Scarpato, Paolo Quitadamo, Enriqueta Roman, Danijela Jojkic-Pavkov, Sanja Kolacek, Alexandra Papadopoulou, Eleftheria Roma, Raanan Shamir, Michal R B Lev, Branko Lutovac, Veselinka Djurisic, Rok Orel, Aziz Koleilat, Sirin Mneimneh, Vincenzo Coppola, Enrico Corazziari, Annamaria Staiano
OBJECTIVES: Childhood functional gastrointestinal disorders (FGIDs) are common conditions associated with significant morbidity and high healthcare costs. This multicenter study aimed at assessing the clinical approach to infants (0-6 months) and children/adolescents (4-18 years) with suspected FGIDs by pediatricians from the Mediterranean Area. METHODS: A survey evaluating the diagnostic approach, including the use of Rome II and III criteria, and the therapeutic management of some of the most prevalent FGIDs, such as irritable bowel syndrome (IBS), functional constipation (FC), and functional regurgitation (FR), was distributed to a sample of pediatricians...
June 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28524640/segmental-colonic-dilation-is-associated-with-premature-termination-of-high-amplitude-propagating-contractions-in-children-with-intractable-functional-constipation
#17
I J N Koppen, B P Thompson, E J Ambeba, V A Lane, D G Bates, P C Minneci, K J Deans, M A Levitt, R J Wood, M A Benninga, C Di Lorenzo, D Yacob
BACKGROUND: Colonic dilation is common in children with intractable functional constipation (FC). Our aim was to describe the association between segmental colonic dilation and colonic dysmotility in children with FC. METHODS: We performed a retrospective study on 30 children with intractable FC (according to the Rome III criteria) who had undergone colonic manometry and contrast enema within a 12-month time period. Colonic diameter was measured at 5 cm intervals from the anal verge up to the splenic flexure...
May 19, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/28522332/towards-measles-elimination-in-italy-virological-surveillance-and-genotypes-trend-2013-2015
#18
Fabio Magurano, Melissa Baggieri, Antonietta Filia, Martina Del Manso, Tiziana Lazzarotto, Antonella Amendola, Pierlanfranco D'Agaro, Maria Chironna, Filippo Ansaldi, Stefania Iannazzo, Paola Bucci, Antonella Marchi, Loredana Nicoletti
In accordance with the goal of the World Health Organization Regional Office for Europe, the Italian National Measles and Rubella Elimination Plan aimed to interrupt indigenous measles transmission in Italy by the end of 2015. However, from 2013 to 2015, Italy experienced high measles burden with 4902 measles cases (49.3% laboratory-confirmed) reported to the enhanced measles surveillance system (cumulative incidence in the triennium reference period: 2.4/100,000 population). The measles elimination goal was not reached...
May 15, 2017: Virus Research
https://www.readbyqxmd.com/read/28514399/-disaccharidase-deficiency-and-functional-bowel-diseases
#19
A I Parfenov, O V Akhmadullina, E A Sabelnikova, N I Belostotsky, M V Kirova, S G Khomeriki, S V Bykova
AIM: To elucidate the role of intestinal carbohydrases (glucoamylase, maltase, sucrose, and lactase) in the etiology and pathogenesis of functional bowel diseases (FBD). SUBJECTS AND METHODS: 74 patients (36 men and 38 women) aged 18 to 50 years with FBD were examined. According to Rome IV criteria (2016), there was diarrhea-predominant irritable bowel syndrome (IBS) in 21 patients, functional diarrhea (FD) in 33, constipation-predominant IBS in 6, functional constipation (FC) in 4, and mixed IBS in 10...
2017: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/28509521/dermatofibrosarcoma-protuberans-when-the-age-makes-the-difference
#20
Giovanni Paolino, Dario Didona, Ugo Bottoni, Federico Romaniello, Paola Corsetti, Antonio G Richetta
BACKGROUND: Dermatofibrosarcoma protuberans is a malignant tumor that affects exclusively the skin. It is a low- grade malignant tumor of subcutaneous tissues, characterized by a local recurrence but it seldom metastasizes. This study aims to evaluate the impact of different clinical parameters on disease free survival and overall survival of dermatofibrosarcoma protuberans patients. METHODS: A retrospective study of data including 17 cases of dermatofibrosarcoma protuberans (11 male, 6 female) retrieved from the files of the Dermatology Clinics of La Sapienza, University of Rome...
May 16, 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
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