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https://www.readbyqxmd.com/read/28524640/segmental-colonic-dilation-is-associated-with-premature-termination-of-high-amplitude-propagating-contractions-in-children-with-intractable-functional-constipation
#1
I J N Koppen, B P Thompson, E J Ambeba, V A Lane, D G Bates, P C Minneci, K J Deans, M A Levitt, R J Wood, M A Benninga, C Di Lorenzo, D Yacob
BACKGROUND: Colonic dilation is common in children with intractable functional constipation (FC). Our aim was to describe the association between segmental colonic dilation and colonic dysmotility in children with FC. METHODS: We performed a retrospective study on 30 children with intractable FC (according to the Rome III criteria) who had undergone colonic manometry and contrast enema within a 12-month time period. Colonic diameter was measured at 5 cm intervals from the anal verge up to the splenic flexure...
May 19, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/28522332/towards-measles-elimination-in-italy-virological-surveillance-and-genotypes-trend-2013-2015
#2
Fabio Magurano, Melissa Baggieri, Antonietta Filia, Martina Del Manso, Tiziana Lazzarotto, Antonella Amendola, Pierlanfranco D'Agaro, Maria Chironna, Filippo Ansaldi, Stefania Iannazzo, Paola Bucci, Antonella Marchi, Loredana Nicoletti
In accordance with the goal of the World Health Organization Regional Office for Europe, the Italian National Measles and Rubella Elimination Plan aimed to interrupt indigenous measles transmission in Italy by the end of 2015. However, from 2013 to 2015, Italy experienced high measles burden with 4,902 measles cases (49.3% laboratory-confirmed) reported to the enhanced measles surveillance system (cumulative incidence in the triennium reference period: 2.4/100,000 population). The measles elimination goal was not reached...
May 15, 2017: Virus Research
https://www.readbyqxmd.com/read/28514399/-disaccharidase-deficiency-and-functional-bowel-diseases
#3
A I Parfenov, O V Akhmadullina, E A Sabelnikova, N I Belostotsky, M V Kirova, S G Khomeriki, S V Bykova
AIM: To elucidate the role of intestinal carbohydrases (glucoamylase, maltase, sucrose, and lactase) in the etiology and pathogenesis of functional bowel diseases (FBD). SUBJECTS AND METHODS: 74 patients (36 men and 38 women) aged 18 to 50 years with FBD were examined. According to Rome IV criteria (2016), there was diarrhea-predominant irritable bowel syndrome (IBS) in 21 patients, functional diarrhea (FD) in 33, constipation-predominant IBS in 6, functional constipation (FC) in 4, and mixed IBS in 10...
2017: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/28509521/dermatofibrosarcoma-protuberans-when-the-age-makes-the-difference
#4
Giovanni Paolino, Dario Didona, Ugo Bottoni, Federico Romaniello, Paola Corsetti, Antonio G Richetta
BACKGROUND: Dermatofibrosarcoma protuberans is a malignant tumor that affects exclusively the skin. It is a low- grade malignant tumor of subcutaneous tissues, characterized by a local recurrence but it seldom metastasizes. This study aims to evaluate the impact of different clinical parameters on disease free survival and overall survival of dermatofibrosarcoma protuberans patients. METHODS: A retrospective study of data including 17 cases of dermatofibrosarcoma protuberans (11 male, 6 female) retrieved from the files of the Dermatology Clinics of La Sapienza, University of Rome...
May 16, 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/28508427/evaluation-of-benefit-and-tolerability-of-iqp-cl-101-xanthofen-in-the-symptomatic-improvement-of-irritable-bowel-syndrome-a-double-blinded-randomised-placebo-controlled-clinical-trial
#5
Felix Alt, Pee-Win Chong, Emily Teng, Ralf Uebelhack
Irritable bowel syndrome (IBS) is a functional bowel disorder of unknown aetiology. There is currently no known cure, and pharmacological interventions are usually targeting symptomatic relief, where natural and herbal remedies also play a role. This study aimed to evaluate the benefit and tolerability of IQP-CL-101 in symptomatic IBS relief. A double-blinded, randomised, placebo-controlled trial was conducted over 8 weeks. A total of 99 subjects fulfilling ROME-III criteria for IBS were randomised into two groups, given either two IQP-CL-101 softgels or matching placebo twice daily before main meals...
May 16, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28497589/the-asia-pacific-colorectal-screening-score-is-useful-to-stratify-risk-for-colorectal-advanced-neoplasms-in-vietnamese-patients-with-irritable-bowel-syndrome
#6
Duc Trong Quach, Toru Hiyama, Thu Anh Nguyen, Hoa Quoc Ly, Shinji Tanaka
BACKGROUND: The Asia Pacific Colorectal Screening (APCS) score has been validated in several populations but not yet in patients with irritable bowel syndrome (IBS). AIM: To assess the performance of APCS score in stratifying risk of colorectal advanced neoplasms (CAN) in Vietnamese IBS patients. METHODS: Consecutive patients who fulfilled IBS diagnosis criteria according to the Rome III were prospectively enrolled and underwent colonoscopy...
May 11, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28486413/hospitalizations-in-pediatric-and-adult-patients-for-all-cancer-type-in-italy-the-epikit-study-under-the-e-u-coheirs-project-on-environment-and-health
#7
Prisco Piscitelli, Immacolata Marino, Andrea Falco, Matteo Rivezzi, Roberto Romano, Restituta Mazzella, Cosimo Neglia, Giulia Della Rosa, Giuseppe Pellerano, Giuseppe Militerno, Adriana Bonifacino, Gaetano Rivezzi, Roberto Romizi, Giuseppe Miserotti, Maurizio Montella, Fabrizio Bianchi, Alessandra Marinelli, Antonella De Donno, Giovanni De Filippis, Giuseppe Serravezza, Gianluca Di Tanna, Dennis Black, Valerio Gennaro, Mario Ascolese, Alessandro Distante, Ernesto Burgio, Massimo Crespi, Annamaria Colao
Background: Cancer Registries (CRs) remain the gold standard for providing official epidemiological estimations. However, due to CRs' partial population coverage, hospitalization records might represent a valuable tool to provide additional information on cancer occurrence and expenditures at national/regional level for research purposes. The Epidemiology of Cancer in Italy (EPIKIT) study group has been built up, within the framework of the Civic Observers for Health and Environment: Initiative of Responsibility and Sustainability (COHEIRS) project under the auspices of the Europe for Citizens Program, to assess population health indicators...
May 9, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28446492/hepatic-fibrosis-is-universal-following-fontan-operation-and-severity-is-associated-with-time-from-surgery-a-liver-biopsy-and-hemodynamic-study
#8
David J Goldberg, Lea F Surrey, Andrew C Glatz, Kathryn Dodds, Michael L O'Byrne, Henry C Lin, Mark Fogel, Jonathan J Rome, Elizabeth B Rand, Pierre Russo, Jack Rychik
BACKGROUND: Congestive hepatopathy is a recognized complication of Fontan physiology. Data regarding the incidence of hepatopathy and risk factors are lacking. METHODS AND RESULTS: Liver biopsies and cardiac catherizations were performed as part of an evaluation offered to all patients ≥10 years after Fontan. Quantitative determination of hepatic fibrosis was performed using Sirius red staining with automated calculation of collagen deposition per slide (%CD)...
April 26, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28431454/da-9701-improves-colonic-transit-time-and-symptoms-in-patients-with-functional-constipation-a-prospective-study
#9
Su Young Kim, Hyun Sun Woo, Sung Han Choi, Dong Kyun Park, Kwang An Kwon, Jun-Won Chung, Yoon Jae Kim, Jung Ho Kim, Su Ji Kim, Kyoung Oh Kim
BACKGROUND AND AIM: DA-9701, a newly developed prokinetic agent formulated with Pharbitis Semen and Corydalis Tuber, has been shown to effectively treat functional dyspepsia. Recently, it has also been suspected to improve gastrointestinal motor function. The aims of this study were to assess the effect of DA-9701 on colonic transit time (CTT) and symptoms of functional constipation. METHODS: We prospectively enrolled 33 patients with functional constipation based on the Rome III criteria...
April 21, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28422887/epigastric-symptoms-of-gallbladder-dyskinesia-mistaken-for-functional-dyspepsia-retrospective-observational-study
#10
Sung Won Jung, Min Sun Joo, Hyun Chang Choi, Sung Ill Jang, Young Sik Woo, Jin Bae Kim, Sang Hoon Park, Myung Seok Lee
Functional dyspepsia (FD) is a constellation of epigastric symptoms originating in the gastroduodenal region without organic and metabolic cause. However, similar confounding symptoms can also appear in patients with gallbladder (GB) dyskinesia. Therefore, symptoms of GB dyskinesia may be mistaken for FD. We aimed to identify GB dyskinesia as a cause of FD symptoms compatible with the Rome IV criteria and the need for an evaluation of GB function in patients with FD symptoms.We investigated information of patients with FD symptoms who underwent a quantitative Tc-diisoproyl iminodiacetic acid cholescintigraphy (DISIDA scan) through electronic medical records, and GB dyskinesia was judged to be the cause of the FD symptoms if the symptoms disappeared as GB function normalized on the follow-up DISIA scan in patient with decreased GB function on the initial DISIDA scan...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28422279/efficacy-and-safety-of-mechanical-thrombectomy-in-older-adults-with-acute-ischemic-stoke
#11
Fabrizio Sallustio, Giacomo Koch, Caterina Motta, Marina Diomedi, Fana Alemseged, Vittoria C D'Agostino, Simone Napolitano, Domenico Samà, Alessandro Davoli, Daniel Konda, Daniele Morosetti, Enrico Pampana, Roberto Floris, Roberto Gandini
OBJECTIVES: To evaluate the safety and efficacy of endovascular therapy in elderly adults treated for acute ischemic stroke. DESIGN: Retrospective cohort study. SETTING: Comprehensive Stroke Center, University of Tor Vergata, Rome, Italy. PARTICIPANTS: Elderly adults treated for acute ischemic stroke (N = 219). MEASUREMENTS: Participants were divided into two groups based on their age (n = 62, ≥80; n = 157, <80)...
April 19, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28419119/plasma-ghrelin-level-and-plasma-ghrelin-obestatin-ratio-are-related-to-intestinal-metaplasia-in-elderly-patients-with-functional-dyspepsia
#12
Su Hwan Kim, Ji Won Kim, Junsu Byun, Ji Bong Jeong, Byeong Gwan Kim, Kook Lae Lee
BACKGROUND: Whether plasma ghrelin/obestatin levels are associated with Helicobacter pylori (H. pylori) infection, subtypes of functional dyspepsia (FD), and gastric mucosal histology has not yet been established in elderly patients. OBJECTIVE: The aim of this study was to determine whether plasma ghrelin and obestatin levels are related to gastric mucosal histology, H. pylori infection, and FD subtypes in elderly patients with FD. METHODS: Ninety-two patients diagnosed with FD and older than 60 years (median age 69...
2017: PloS One
https://www.readbyqxmd.com/read/28401774/effect-of-descurainia-sophia-l-webb-ex-prantl-on-adult-functional-constipation-a-prospective-pilot-study
#13
Rasool Choopani, Anahita Ghourchian, Homa Hajimehdipoor, Mohammad Kamalinejad, Fatemeh Ghourchian
Chronic constipation is a common gastrointestinal disorder that effects an estimated 12% to 30% of general population worldwide. Descurainia sophia L. known commonly as flixweed acts as first-line medical treatment for constipation in Iranian traditional medicine. The aim of this study was to assess the efficacy and safety of this remedy for treating functional constipation by standard assessments. The Rome III criteria for functional constipation were the basis for diagnosis. All participants underwent a 4-week treatment...
January 1, 2017: Journal of Evidence-based Complementary & Alternative Medicine
https://www.readbyqxmd.com/read/28375941/two-tumors-in-1-what-should-be-the-therapeutic-target-pediatric-germ-cell-tumor-with-somatic-malignant-transformation
#14
Cecile Faure Conter, Brice Fresneau, Estelle Thebaud, Amandine Bertrand, Frederique Dijoud, Angelique Rome, Cecile Dumesnil, Marie Pierre Castex, Anguella Ghanem, Daniel Orbach
BACKGROUND: Germ cell tumors with somatic malignant transformation (GCT with SMT) are rare in children and poorly described. Data are missing to determine if therapies should target the GCT, the SMT compound, or both simultaneously. PATIENTS AND METHODS: A retrospective national study was conducted in the Société Française des cancers de l'Enfant (SFCE) Centers. Medical records from patients aged 0 to 18 years diagnosed with GCT with SMT between 2000 and 2015 were analyzed...
April 3, 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/28366993/a-multicenter-randomized-trial-comparing-rabeprazole-and-itopride-in-patients-with-functional-dyspepsia-in-japan-the-nagoya-study
#15
Takeshi Kamiya, Michiko Shikano, Eiji Kubota, Tsutomu Mizoshita, Tsuneya Wada, Satoshi Tanida, Hiromi Kataoka, Hiroshi Adachi, Makoto Hirako, Noriaki Okuda, Takashi Joh
The aims of this study were to compare the therapeutic effects of a proton pump inhibitor (PPI), rabeprazole (RPZ), and a prokinetic agent, itopride (ITO), and to investigate the role of PPI in the treatment strategy for Japanese functional dyspepsia (FD) patients. We randomly assigned 134 patients diagnosed by Rome III criteria to 4 weeks treatment with RPZ 10 mg/day (n = 69) or ITO 150 mg/day (n = 65). Dyspeptic symptoms were evaluated using FD scores at baseline and after 1, 2 and 4 weeks of treatment...
March 2017: Journal of Clinical Biochemistry and Nutrition
https://www.readbyqxmd.com/read/28342737/are-lower-urinary-tract-symptoms-in-children-associated-with-urinary-symptoms-in-their-mothers
#16
Ariane S Sampaio, Luis Gustavo A Fraga, Bruno A Salomão, Júlia B Oliveira, Camila L Seixas, Maria Luiza Veiga, José Murillo B Netto, Ubirajara Barroso
BACKGROUND: The association between parents who suffered daytime incontinence as children and children who are incontinence has been reported. However, the association of lower urinary tract (LUT) dysfunction in children and urinary symptoms in mothers has not been studied. OBJECTIVE: To test the hypothesis that the children of mothers with lower urinary tract symptoms (LUTS) are more likely to have urinary symptoms. STUDY DESIGN: A cross-sectional multicenter study was conducted in two cities in Brazil...
February 17, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28337444/female-functional-constipation-is-associated-with-overactive-bladder-symptoms-and-urinary-incontinence
#17
Takahiro Maeda, Masuomi Tomita, Atsushi Nakazawa, Gen Sakai, Shinsuke Funakoshi, Akari Komatsuda, Yujiro Ito, Hirohiko Nagata, Nobuhiro Tsukada, So Nakamura
This noninterventional cross-sectional study aims to assess the association between functional constipation (FC) and urinary symptoms in female patients with no treatment for urination and defecation. The Rome III criteria for evaluation of defecation, Overactive Bladder Symptom Score (OABSS) for evaluation of urinary symptoms, and clinical features were investigated in 145 female patients. Latent FC and moderate to severe overactive bladder (OAB) were defined on the basis of positivity for two or more of the Rome III criteria and an OABSS ≥ 6 with OABSS Q3 ≥ 2, respectively...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28334433/dietary-interventions-for-recurrent-abdominal-pain-in-childhood
#18
REVIEW
Tamsin V Newlove-Delgado, Alice E Martin, Rebecca A Abbott, Alison Bethel, Joanna Thompson-Coon, Rebecca Whear, Stuart Logan
BACKGROUND: This is an update of the original Cochrane review, last published in 2009 (Huertas-Ceballos 2009). Recurrent abdominal pain (RAP), including children with irritable bowel syndrome, is a common problem affecting between 4% and 25% of school-aged children. For the majority of such children, no organic cause for their pain can be found on physical examination or investigation. Many dietary inventions have been suggested to improve the symptoms of RAP. These may involve either excluding ingredients from the diet or adding supplements such as fibre or probiotics...
March 23, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28333903/-evaluation-of-oro-cecal-transit-time-in-patients-with-irritable-bowel-syndrome-with-cereal-products-intolerance
#19
Aleksandra Błońska, Paulina Konrad, Jan Chojnacki, Cezary Chojnacki
The main symptoms of irritable bowel syndrome (IBS) include abnormal frequency of bowel movements. On this basis, three main clinical types of the disease have been distinguished, i.e.: constipation (IBSC), diarrhea (IBS-D) and mixed-type (IBS-M) in accordance with the Rome III criteria. These disorders mainly affect the colon, but symptoms related to upper gastrointestinal tract are also often observed. AIM: The aim of the study was to assess the oro-caecal transit time in patients with irritable bowel syndrome with IgG-dependent hypersensitivity to cereal products...
March 21, 2017: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28331539/randomized-placebo-controlled-phase-iv-pilot-study-of-ramosetron-to-evaluate-the-co-primary-end-points-in-male-patients-with-irritable-bowel-syndrome-with-diarrhea
#20
Motoko Ida, Akito Nishida, Hiraku Akiho, Yoshihiro Nakashima, Kei Matsueda, Shin Fukudo
BACKGROUND: Global assessment allows patients to assess improvement in multiple irritable bowel syndrome (IBS) symptoms. However, it was deemed important to assess "clinically meaningful improvements, focusing on the patient's chief complaint and the severity of major IBS symptoms" in addition to global assessment to show how ramosetron is effective for individual IBS symptoms. This is a pilot study to explore clinical endpoints focusing on the chief complaint of patients with IBS with diarrhea (IBS-D)...
2017: BioPsychoSocial Medicine
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