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https://www.readbyqxmd.com/read/28100464/six-month-market-exclusivity-extensions-to-promote-research-offer-substantial-returns-for-many-drug-makers
#1
Aaron S Kesselheim, Benjamin N Rome, Ameet Sarpatwari, Jerry Avorn
To incentivize pharmaceutical manufacturers to invest in areas of unmet medical need, policy makers frequently propose extending the market exclusivity period of desired drugs. Some such proposals are modeled after the pediatric exclusivity patent extension program, which since 1997 has provided six additional months of market exclusivity for drugs studied in children. The most recent proposal would encourage rare disease research by providing six months of extended exclusivity for any existing drug that is granted subsequent FDA approval for a new rare disease indication...
January 18, 2017: Health Affairs
https://www.readbyqxmd.com/read/28099778/pseudozyma-and-other-non-candida-opportunistic-yeast-bloodstream-infections-in-a-large-stem-cell-transplant-center
#2
Anupam Pande, Lemuel R Non, Rizwan Romee, Carlos A Q Santos
INTRODUCTION: Non-Candida opportunistic yeasts are emerging causes of bloodstream infection (BSI) in immunocompromised hosts. However, their clinical presentation, management, and outcomes in stem cell transplant (SCT) recipients are not well described. CASE REPORT AND REVIEW: We report the first case to our knowledge of Pseudozyma BSI in a SCT recipient. He had evidence of cutaneous involvement, which has not been previously described in the literature. He became infected while neutropenic and receiving empiric micafungin, which is notable because Pseudozyma is reported to be resistant to echinocandins...
January 18, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/28072880/characterisation-of-early-life-fecal-microbiota-in-susceptible-and-healthy-pigs-to-post-weaning-diarrhoea
#3
Samir Dou, Pascale Gadonna-Widehem, Véronique Rome, Dounia Hamoudi, Larbi Rhazi, Lyes Lakhal, Thibaut Larcher, Narges Bahi-Jaber, Arturo Pinon-Quintana, Alain Guyonvarch, Isabelle L E Huërou-Luron, Latifa Abdennebi-Najar
Early-life microbial exposure is of particular importance to growth, immune system development and long-lasting health. Hence, early microbiota composition is a promising predictive biomarker for health and disease but still remains poorly characterized in regards to susceptibility to diarrhoea. In the present study, we aimed to assess if gut bacterial community diversity and composition during the suckling period were associated with differences in susceptibility of pigs to post-weaning diarrhoea. Twenty piglets from 5 sows (4 piglets / litter) were weaned in poor housing conditions to challenge their susceptibility to post-weaning diarrhoea...
2017: PloS One
https://www.readbyqxmd.com/read/28072728/upper-gastrointestinal-symptoms-in-autoimmune-gastritis-a-cross-sectional-study
#4
Marilia Carabotti, Edith Lahner, Gianluca Esposito, Maria Carlotta Sacchi, Carola Severi, Bruno Annibale
Autoimmune gastritis is often suspected for its hematologic findings, and rarely the diagnosis is made for the presence of gastrointestinal symptoms. Aims of this cross-sectional study were to assess in a large cohort of patients affected by autoimmune gastritis the occurrence and the pattern of gastrointestinal symptoms and to evaluate whether symptomatic patients are characterized by specific clinical features.Gastrointestinal symptoms of 379 consecutive autoimmune gastritis patients were systematically assessed and classified following Rome III Criteria...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28072460/psychosocial-interventions-for-recurrent-abdominal-pain-in-childhood
#5
REVIEW
Rebecca A Abbott, Alice E Martin, Tamsin V Newlove-Delgado, Alison Bethel, Joanna Thompson-Coon, Rebecca Whear, Stuart Logan
BACKGROUND: This review supersedes the original Cochrane review first published in 2008 (Huertas-Ceballos 2008).Between 4% and 25% of school-aged children complain of recurrent abdominal pain (RAP) severe enough to interfere with their daily activities. No organic cause for this pain can be found on physical examination or investigation for the majority of such children. Although many children are managed by reassurance and simple measures, a large range of psychosocial interventions involving cognitive and behavioural components have been recommended...
January 10, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28050419/prevalence-of-irritable-bowel-syndrome-ibs-migraine-and-co-existing-ibs-migraine-in-medical-students
#6
Irin Perveen, Rukhsana Parvin, Madhusudan Saha, Md Shafiqul Bari, Md Nazmul Huda, Mridul Kanti Ghosh
INTRODUCTION: Irritable Bowel Syndrome (IBS) and migraine frequently co-exist. Stress is a major contributing factor for both. Our medical students are subjected to stress related to the implicit responsibility of courses. But the prevalence of IBS, migraine and co-existing migraine in medical students is not known. AIM: To estimate the prevalence of migraine, IBS and co-existing IBS and migraine among medical students. A Cross-Sectional Survey. MATERIALS AND METHODS: Self-reported questionnaire based study, was conducted in which migraine was defined according to International Headache Society (IHS) criteria while IBS by both Asian criteria and Rome III criteria...
November 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28044051/maturation-phenotype-of-peripheral-blood-monocyte-macrophage-after-stimulation-with-lipopolysaccharides-in-irritable-bowel-syndrome
#7
Oscar A Rodríguez-Fandiño, Joselín Hernández-Ruiz, Yolanda López-Vidal, Luis Charúa-Guindic, Galileo Escobedo, Max J Schmulson
Background/Aims: Abnormal immune regulation and increased intestinal permeability augmenting the passage of bacterial molecules that can activate immune cells, such as monocytes/macrophages, have been reported in irritable bowel syndrome (IBS). To compare the maturation phenotype of monocytes/macrophages (CD14+) from IBS patients and controls in the presence or absence of E. coli lipopolysaccharides (LPS), in vitro. Methods: Mononuclear cells were isolated from peripheral blood of 20 Rome II-IBS patients and 19 controls and cultured with or without LPS for 72 hours...
January 2, 2017: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/28043109/a-possible-pathogenic-linkage-among-headache-migraine-and-nocturnal-enuresis-in-children
#8
Pietro Ferrara, Livia Dell'Aquila, Giacomo Perrone, Giulia Spina, Francesco Miconi, Valentina Rapaccini, Ester Del Vescovo, Vincenzo Di Lazzaro, Alberto Verrotti
PURPOSE: This study aims to evaluate the prevalence of headaches and migraine in children with nocturnal enuresis (NE) and to improve knowledge on these conditions. In particular, for this purpose, a possible pathogenic relationship linking both conditions and the impact of headaches and migraine on NE persistence was evaluated. METHODS: Researchers enrolled 123 children with NE, aged between 5 and 15 years, referred to the Service of Pediatrics, Campus Bio-Medico University Hospital of Rome between January 2014 and January 2015...
December 2016: International Neurourology Journal
https://www.readbyqxmd.com/read/28039670/hepatic-encephalopathy-is-associated-with-persistent-learning-impairments-despite-adequate-medical-treatment-a-multicenter-international-study
#9
Silvia Nardelli, Sanath Allampati, Oliviero Riggio, Kevin D Mullen, Ravi Prakash, Stefania Gioia, Ariel Unser, Melanie B White, Andrew C Fagan, James B Wade, Alessio Farcomeni, Edith A Gavis, Jasmohan S Bajaj
BACKGROUND: Hepatic encephalopathy (HE) is considered reversible regarding mental status but may not be cognitively in single-center studies. AIM: To evaluate persistence of learning impairment in prior HE compared to those who never experienced HE (no-HE) in a multicenter study. METHODS: A total of 174 outpatient cirrhotics from three centers (94 Virginia, 30 Ohio, and 50 Rome; 36 prior HE) underwent psychometric hepatic encephalopathy score (PHES) and inhibitory control (ICT) testing at baseline and then at least 7 days apart...
December 30, 2016: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28028658/chronic-abdominal-pain-and-symptoms-5%C3%A2-years-after-gastric-bypass-for-morbid-obesity
#10
Ingvild K Høgestøl, Monica Chahal-Kummen, Inger Eribe, Cathrine Brunborg, Audun Stubhaug, Stephen Hewitt, Jon Kristinsson, Tom Mala
INTRODUCTION: Roux-en-Y gastric bypass (RYGB) is widely performed as treatment of morbid obesity. Long-term weight loss, effects on co-morbidities, and quality of life after RYGB have been well addressed. Other long-term outcomes are less elucidated. The aim of this study was to evaluate the prevalence, symptom characteristics, and possible predictors of chronic abdominal pain and gastrointestinal symptoms during consultations 5 years after RYGB. METHODS: A 5-year follow-up study of patients operated with RYGB 2008-2009 was performed...
December 27, 2016: Obesity Surgery
https://www.readbyqxmd.com/read/28009394/eighty-years-of-cirm-a-journey-of-commitment-and-dedication-in-providing-maritime-medical-assistance
#11
Syed Sarosh Mahdi, Francesco Amenta
BACKGROUND: A review of activities of Centro Internazionale Radio Medico (International Radio Medical Centre, CIRM) from its foundation in 1935 until its 80th anniversary in 2015 was accomplished. CIRM was founded in 1935 to provide medical assistance via radio to ships with no doctor on board and other distant patients who cannot be reached by a doctor. In 1950 CIRM was established as a non-profit-making foundation and has benefited since 1957 from an annual contribution from the Italian government...
2016: International Maritime Health
https://www.readbyqxmd.com/read/27997551/the-prevalence-and-symptoms-characteristic-of-functional-constipation-using-rome-iii-diagnostic-criteria-among-tertiary-education-students
#12
Ying Jye Lim, Jamaluddin Rosita, Jin Yu Chieng, Abu Saad Hazizi
BACKGROUND AND AIMS: Functional constipation is very common with heterogeneous symptoms that have substantial impact on patient quality of life as well as medical resources which are rarely reported as life-threatening. The aim of this study is to examine the prevalence and symptoms characteristic of functional constipation (FC) by using Rome III diagnostic criteria among tertiary education students with an intention to introduce treatment in the future. METHODS: Demographic, socio-economics characteristics and symptoms of FC using the Rome III criteria were sought using a questionnaire administered to Malaysian students in a tertiary education setting...
2016: PloS One
https://www.readbyqxmd.com/read/27979583/abdominal-pain-associated-functional-gastrointestinal-disorder-prevalence-in-children-and-adolescents-with-celiac-disease-on-gluten-free-diet-a-multinational-study
#13
Miguel Saps, Naire Sansotta, Sean Bingham, Giuseppe Magazzu, Caterina Grosso, Simone Romano, Cenk Pusatcioglu, Stefano Guandalini
OBJECTIVE: To test the hypothesis that children with celiac disease (CD) on gluten-free diet are at increased risk of abdominal pain (AP) associated-functional gastrointestinal disorders (FGIDs). STUDY DESIGN: This was a multinational cross-sectional study performed from 2014 to 2015. Patients 4-18 years of age with CD on gluten-free diet for longer than 6 months were recruited from pediatric CD clinics in US and Italy. Control groups included siblings of children with CD (with normal tissue transglutaminase levels) and unrelated controls...
December 13, 2016: Journal of Pediatrics
https://www.readbyqxmd.com/read/27973563/frequent-use-of-emergency-departments-by-the-elderly-population-when-continuing-care-is-not-well-established
#14
Jacopo M Legramante, Laura Morciano, Francesca Lucaroni, Francesco Gilardi, Emanuele Caredda, Alessia Pesaresi, Massimo Coscia, Stefano Orlando, Antonella Brandi, Germano Giovagnoli, Vito N Di Lecce, Giuseppe Visconti, Leonardo Palombi
INTRODUCTION: The elderly, who suffer from multiple chronic diseases, represent a substantial proportion of Emergency Department (ED) frequent users, thus contributing to ED overcrowding, although they could benefit from other health care facilities, if those were available. The aim of this study was to evaluate and characterize hospital visits of older patients (age 65 or greater) to the ED of a university teaching hospital in Rome from the 1st of January to the 31st of December 2014, in order to identify clinical and social characteristics potentially associated with "elderly frequent users"...
2016: PloS One
https://www.readbyqxmd.com/read/27958284/pathophysiological-abnormalities-in-functional-dyspepsia-subgroups-according-to-the-rome-iii-criteria
#15
H Vanheel, F Carbone, L Valvekens, M Simren, H Tornblom, T Vanuytsel, L Van Oudenhove, J Tack
OBJECTIVES: The Rome III criteria proposed to subdivide functional dyspepsia (FD) into a postprandial distress syndrome (PDS) group, characterized by the presence of postprandial fullness and/or early satiety, and an epigastric pain syndrome (EPS) group, characterized by the presence of epigastric pain and/or epigastric burning. It has been suggested that different pathophysiological mechanisms underlie the symptom presentations in these subgroups that might determine treatment choices...
January 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/27935797/abstracts-of-the-28th-annual-conference-of-the-international-society-for-environmental-epidemiology-isee-1-4-september-2016-rome-italy
#16
(no author information available yet)
The 28th annual conference of the International Society for Environmental Epidemiology was held 1 - 4 September 2016 in Rome, Italy. The conference theme was "Old and New Risks: Challenges for Environmental Epidemiology." The focus of this year's conference is current and future challenges in exposure assessment, study design, and data analyses.
August 26, 2016: Environmental Health Perspectives
https://www.readbyqxmd.com/read/27935142/sharing-information-about-cancer-with-one-s-family-is-associated-with-improved-quality-of-life
#17
Carlo Lai, Beatrice Borrelli, Paola Ciurluini, Paola Aceto
OBJECTIVE: The aim of this study was to investigate the association between cancer patients' ability to share information about their illness with their social network and attachment style dimensions, alexithymia and quality of life. We hypothesised that ability to share information about one's cancer with family, friends and medical teams would be positively associated with quality of life and secure attachment and negatively associated with alexithymia. METHODS: Forty-five cancer patients were recruited from the Psycho-oncology unit of the San Camillo-Forlanini Hospital in Rome...
December 9, 2016: Psycho-oncology
https://www.readbyqxmd.com/read/27922029/safety-of-eluxadoline-in-patients-with-irritable-bowel-syndrome-with-diarrhea
#18
Brooks D Cash, Brian E Lacy, Philip S Schoenfeld, Leonard S Dove, Paul S Covington
OBJECTIVES: Eluxadoline is a mixed μ-opioid receptor (OR) and κ-OR agonist and δ-OR antagonist, approved for the treatment of irritable bowel syndrome with diarrhea (IBS-D). This analysis evaluated the safety and tolerability of eluxadoline 75 and 100 mg twice daily (BID) in one Phase 2 (IBS-2001) and two Phase 3 (IBS-3001 and IBS-3002) studies. METHODS: Adults with IBS-D (Rome III criteria) were randomized to placebo or eluxadoline (75 or 100 mg) BID for 12 (IBS-2001), 26 (IBS-3002), or 52 (IBS-3001) weeks...
December 6, 2016: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/27922028/a-randomized-double-blind-placebo-controlled-trial-to-examine-the-effectiveness-of-lubiprostone-on-constipation-symptoms-and-colon-transit-time-in-diabetic-patients
#19
Jennifer Christie, Sagar Shroff, Nikrad Shahnavaz, Latoya A Carter, Melanie S Harrison, Karan A Dietz-Lindo, John Hanfelt, Shanthi Srinivasan
OBJECTIVES: Constipation is the most common GI symptom in patients with diabetes mellitus (DM). Importantly, patients with constipation have lower health-related quality of life than those without constipation. Effective therapies for constipation are limited and there is a paucity of data evaluating the treatment of constipation in diabetics. METHODS: Diabetic patients with chronic idiopathic constipation (CIC) as defined by Rome III criteria were recruited from outpatient clinics at a tertiary-care center and a Veterans Administration Hospital...
December 6, 2016: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/27918851/influence-of-a-100-m-simulated-in-water-rescue-on-cardiopulmonary-parameters
#20
Ana Sousa, Ricardo J Fernandes, Núria Rodríguez, J Arturo Abraldes
OBJECTIVE: Cardiopulmonary resuscitation (CPR) after a drowning episode is performed under fatigue conditions. However, the characterization of CPR in this context is still unknown. Our purpose was to investigate the effect of a 100-m simulated in-water rescue on CPR and physiological parameters in trained certified lifeguards. METHODS: Thirty trained certified lifeguards (age 24.6 ± 3.8 yrs; height 178.2 ± 7.4 cm and weight 76.9 ± 10.6 kg) completed two protocols using an adult manikin: (i) 4-min CPR after 4-min baseline conditions (CPR), and (ii) 4-min CPR after a 100-m simulated in-water rescue in the sea (CPR Rescue), both with a compression-ventilation ratio of 30:2...
December 5, 2016: Prehospital Emergency Care
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