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https://www.readbyqxmd.com/read/29335908/surgery-for-abdominal-well-differentiated-liposarcoma
#1
REVIEW
Sara A Mansfield, Raphael E Pollock, Valerie P Grignol
Retroperitoneal sarcomas are rare tumors of which liposarcoma is the most common histology. Surgical resection remains the mainstay of therapy, particularly for the well-differentiated subtype. They can grow to massive size before causing symptoms or detection. Well-differentiated liposarcoma, while having a negligible metastatic rate, is fraught with a high local recurrence rate, despite a complete surgical resection. Reasons for this are not completely known but may be related to a field defect of the retroperitoneal fat creating a niche for recurrence...
January 16, 2018: Current Treatment Options in Oncology
https://www.readbyqxmd.com/read/29333462/assessment-of-ultrasound-radio-guided-occult-lesion-localization-in-non-palpable-breast-lesions
#2
Seyed Ali Alamdaran, Donia Farokh, Ayda Sharifi Haddad, Navid Daghighi, Elaheh Modoodi, Ramin Sadeghi, Mohammad Naser Forghani, Asieh Sadat Fattahi
Objectives: Controversy exists about the localization of non-palpable breast lesions. In many countries, the gold standard for the diagnosis of these lesions is needle localization due to its accuracy. This study sought to compare the ultrasound- and radio-guided occult lesion localization (ROLL) as a simple method with the conventional procedures in terms of their diagnostic power. Methods: This study was conducted on 94 patients with non-palpable breast lesions detected by ultrasonography and localized by the combination of ultrasonography and using radiopharmaceuticals...
2018: Asia Oceania Journal of Nuclear Medicine & Biology
https://www.readbyqxmd.com/read/29322905/pre-discharge-postoperative-radiographs-after-primary-total-knee-replacement-tradition-or-science
#3
S N Sambandam, V Khanna, G Rohinikumar, V Mounasamy
Consistent evidence exists on the inutility of immediate postoperative radiographs after a total knee replacement (TKR). We hypothesized that eliminating the pre-discharge film would not have any effect on the postoperative patient outcomes. Retrospective analysis of prospectively collected data was performed on 220 knees. Patients undergoing a simple primary TKR operated by 2 surgeons (Surgeon A and B) from January 2013 to July 2015 were divided into 2 groups (Groups 1 and 2 having 112 and 108 knees respectively)...
March 2017: Acta Orthopaedica Belgica
https://www.readbyqxmd.com/read/29312767/minor-regression-and-long-time-survival-56-months-in-a-patient-with-malignant-pleural-mesothelioma-under-viscum-album-and-helleborus-niger-extracts-a-case-report
#4
Paul G Werthmann, Gerhard Saltzwedel, Gunver S Kienle
Malignant pleural mesothelioma (MPM) is a rare cancer with a dismal prognosis. Viscum album extracts (VAE) have strong immune stimulatory properties, cytotoxic effects, can downregulate cancer genes and inhibit angiogenesis. VAE are often used as an adjunct treatment in cancer patients but have rarely been investigated in MPM. Helleborus niger extracts (HNE) have been used in anticancer therapy since antiquity, and also show tumor specific cytotoxic effects. We present a case of a 64-year old woman with epithelioid MPM of the right chest with node involvement (T2N1M0, stage III)...
December 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29312541/energy-metabolism-in-glioblastoma-stem-cells-ppar%C3%AE-a-metabolic-adaptor-to-intratumoral-microenvironment
#5
Alessia Fidoamore, Loredana Cristiano, Chiara Laezza, Renato Galzio, Elisabetta Benedetti, Benedetta Cinque, Andrea Antonosante, Michele d'Angelo, Vanessa Castelli, Maria Grazia Cifone, Rodolfo Ippoliti, Antonio Giordano, Annamaria Cimini
Glioblastoma (GB), the most-common cancer in the adult brain, despite surgery and radio/ chemotherapy, is to date almost incurable. Many hypoxic tumors, including GB, show metabolic reprogramming to sustain uncontrolled proliferation, hypoxic conditions and angiogenesis. Peroxisome Proliferator-activated Receptors (PPAR), particularly the α isotype, have been involved in the control of energetic metabolism. Herein, we characterized patient-derived GB neurospheres focusing on their energetic metabolism and PPARα expression...
December 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29310495/outcome-of-carotid-and-subclavian-blowout-syndrome-in-patients-with-pharynx-and-larynx-carcinoma-passing-a-standardized-multidisciplinary-treatment
#6
Constanze Gahleitner, Benedikt Hofauer, Katharina Storck, Andreas Knopf
BACKGROUND: Carotid blowout syndrome (CBS) is one of the most feared emergencies in the head and neck surgery and tends to occur in patients with head and neck cancer, wound complications, pharyngocutaneous fistulas, or after radio(chemo)therapy. CBS is always life threatening and associated with a 50% mortality/morbidity rate. METHODS: Between 2007 and 2015, a total of 51 patients who developed CBS caused by the tumour masses or after radio(chemo)therapy were included...
January 8, 2018: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/29298305/response-monitoring-of-breast-cancer-patients-receiving-neoadjuvant-chemotherapy-using-quantitative-ultrasound-texture-and-molecular-features
#7
Lakshmanan Sannachi, Mehrdad Gangeh, Hadi Tadayyon, Ali Sadeghi-Naini, Sonal Gandhi, Frances C Wright, Elzbieta Slodkowska, Belinda Curpen, William Tran, Gregory J Czarnota
BACKGROUND: Pathological response of breast cancer to chemotherapy is a prognostic indicator for long-term disease free and overall survival. Responses of locally advanced breast cancer in the neoadjuvant chemotherapy (NAC) settings are often variable, and the prediction of response is imperfect. The purpose of this study was to detect primary tumor responses early after the start of neoadjuvant chemotherapy using quantitative ultrasound (QUS), textural analysis and molecular features in patients with locally advanced breast cancer...
2018: PloS One
https://www.readbyqxmd.com/read/29286030/-urgent-surgical-care-for-patients-with-colon-cancer-complicated-by-hemorrhage
#8
A V Shabunin, Z A Bagateliya, I Yu Korzheva, S S Lebedev
AIM: To evaluate an effectiveness of various hemostatic methods in patients with colon and rectal cancer. MATERIAL AND METHODS: 77 urgent patients with colon and rectal cancer complicated by bleeding were enrolled. Medication was effective in 11 patients (group 1), endoscopic hemostasis in 47 patients (group 2), vascular embolization in 2 cases (group 3), internal iliac arteries ligation in 2 patients (group 4), 15 patients underwent emergency resection (group 5)...
2017: Khirurgiia
https://www.readbyqxmd.com/read/29284434/clinicopathological-factors-influencing-the-outcomes-of-surgical-treatment-in-patients-with-t4a-hypopharyngeal-cancer
#9
Sang-Yeon Kim, Young-Soo Rho, Eun-Chang Choi, Min-Sik Kim, Joo-Hyun Woo, Dong Hoon Lee, Eun Jae Chung, Min Woo Park, Da-Hee Kim, Young-Hoon Joo
BACKGROUND: The purpose of this study was to determine prognostic factors influencing outcomes of surgical treatment in patients with T4a hypopharyngeal cancer. METHODS: The present study enrolled 93 patients diagnosed with T4a hypopharyngeal cancer who underwent primary surgery between January 2005 and December 2015 at six medical centers in Korea. Primary tumor sites included pyriform sinus in 71 patients, posterior pharyngeal wall in 14 patients, and postcricoid region in 8 patients...
December 29, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29277357/french-guidelines-on-stereoelectroencephalography-seeg
#10
REVIEW
Jean Isnard, Delphine Taussig, Fabrice Bartolomei, Pierre Bourdillon, Hélène Catenoix, Francine Chassoux, Mathilde Chipaux, Stéphane Clémenceau, Sophie Colnat-Coulbois, Marie Denuelle, Stéphane Derrey, Bertrand Devaux, Georg Dorfmüller, Vianney Gilard, Marc Guenot, Anne-Sophie Job-Chapron, Elisabeth Landré, Axel Lebas, Louis Maillard, Aileen McGonigal, Lorella Minotti, Alexandra Montavont, Vincent Navarro, Anca Nica, Nicolas Reyns, Julia Scholly, Jean-Christophe Sol, William Szurhaj, Agnès Trebuchon, Louise Tyvaert, Maria Paola Valenti-Hirsch, Luc Valton, Jean-Pierre Vignal, Paul Sauleau
Stereoelectroencephalography (SEEG) was designed and developed in the 1960s in France by J. Talairach and J. Bancaud. It is an invasive method of exploration for drug-resistant focal epilepsies, offering the advantage of a tridimensional and temporally precise study of the epileptic discharge. It allows anatomo-electrical correlations and tailored surgeries. Whereas this method has been used for decades by experts in a limited number of European centers, the last ten years have seen increasing worldwide spread of its use...
December 22, 2017: Neurophysiologie Clinique, Clinical Neurophysiology
https://www.readbyqxmd.com/read/29238690/tonsillectomy-comparative-study-of-various-techniques-and-changing-trend
#11
Ravinder Verma, Ravneet Ravinder Verma, Rohan Ravinder Verma
Tonsillectomy is a major surgical procedure in terms of volume in the general otolaryngological practice. It is a 3000-year-old surgical operation, referred in Hindu medicine. There has been a conceptual change in the indications and surgical technique in the last 40 years. A comparative study between the various methods of tonsillectomy was done. The study was carried out in the single institutional set up by the same surgeon but using different techniques. The study aimed at comparing the intra-operative factors (blood loss, time taken for surgery), postoperative results (pain, bleeding, dehydration, time taken for complete healing), and other complications like vomiting and hospitalization time between different groups of surgical methods...
December 2017: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/29237238/directional-probe-for-radio-guided-surgery-a-pilot-study
#12
Roberto Massari, Antonio Ucci, Annunziata D'Elia, Costantino Campisi, Emilio Bertani, Alessandro Soluri
The sentinel lymph node (SLN) biopsy technique has highly evolved during the last twenty years. Consequently, the intraoperative use of Gamma Probes (GPs) for SLN mapping is increased. This preliminary study evaluates a novel directional GP prototype. This proof-of-concept prototype is designed to identify the direction of radiopharmaceuticals uptakes, by combining the information from multiple detectors. The purpose of this work is to develop a tool able to effectively guide the surgeon reducing the surgery time...
December 13, 2017: Medical Physics
https://www.readbyqxmd.com/read/29233454/does-radiotherapy-prior-to-surgery-improve-long-term-prognosis-in-pediatric-colorectal-cancer-in-lower-and-upper-middle-income-countries-with-limited-resources-our-experience-and-literature-review
#13
Yacoob Omar Carrim, Luvo Gaxa, Francisca van der Schyff, Nndweleni Meshack Bida, Fareed Omar, Zarina Lockhat
Colorectal carcinoma in children and adolescents is extremely rare, with an annual incidence <0.3 cases per million, most frequently reported in the second decade of life. It accounts for severe morbidity and poor prognosis owing to the low index of suspicion, delayed diagnosis, advanced stage at presentation and the aggressive tumor nature. Patients present with abdominal pain, vomiting, constipation, abdominal distension, rectal tenesmus, iron-deficiency anemia, change in bowel habit and weight loss...
December 2017: Journal of the Egyptian National Cancer Institute
https://www.readbyqxmd.com/read/29229364/pathology-and-management-of-masses-in-the-accessory-parotid-gland-region-24-year-experience-at-a-single-institution
#14
Hailong Ma, Shufang Jin, Zhong Du, Lizhen Wang, Zhiyuan Zhang, Yan'an Wang
PURPOSE: Masses in the accessory parotid gland (APG) region are clinically rare and their management can lead to conflicts between the need for tumor resection and facial cosmesis. The aim of this study was to analyze the pathological classifications and management of APG lesions in our hospital. MATERIALS AND METHODS: From January 1993 to March 2017, 130 patients with primary tumors in the APG region who underwent surgical treatment were enrolled. Follow-up surveys after surgery were then carried out...
November 17, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/29221663/-long-term-outcomes-of-prostate-cancer-patients-with-lymph-nodes-metastasis-after-radical-prostatectomy-and-pelvic-lymph-node-dissection
#15
S De Vergie, N Gaschignard, M Baron, J Branchereau, F Luyckx, T Butel, M-A Perrouin-Verbe, O Bouchot, J Rigaud
INTRODUCTION: The aim of this study was to evaluate biochemical recurrence-free survival (RFS) and to identify useful predictors of such survival in localized prostate cancer patients (cN0) and pelvic lymph node metastasis (pN+) treated with radical prostatectomy and pelvic lymph node dissection. PATIENTS AND METHODS: This multicenter and retrospective study, assessed overall survival (OS), cancer specific survival (CSS) and biochemical recurrence-free survival (RFS), between January 2005 until December 2010 with 5 years of distance...
December 5, 2017: Progrès en Urologie
https://www.readbyqxmd.com/read/29215440/the-aesthetic-analyzing-of-midface-ratio-after-folding-aponeurosis-of-levator-palpebrae-superioris-muscle-in-the-ptosis-correction
#16
Chenyang Ji, Ruiting Li, Wei He, Jinming Zhang
BACKGROUND: Some fordless-eyelid patients with moderate upper lid ptosis characterize in a higher eyebrow position which leads to an increased midfacial ratio. Apart from performing blepharoplasty to create dynamic folds, additional procedures such as folding aponeurosis of levator palpebrae superioris muscle were effective to revise the enlarged ratio of midface through lowering eyebrow, which gains good aesthetic results. However, the specific changes in the proportion of facial aesthetics and the importance of these change were serious lack in the literature as far as the authors know...
December 6, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29199006/lb-100-a-novel-protein-phosphatase-2a-pp2a-inhibitor-sensitizes-malignant-meningioma-cells-to-the-therapeutic-effects-of-radiation
#17
Winson S C Ho, Saman Sizdahkhani, Shuyu Hao, Hua Song, Ashlee Seldomridge, Anita Tandle, Dragan Maric, Tamalee Kramp, Rongze Lu, John D Heiss, Kevin Camphausen, Mark R Gilbert, Zhengping Zhuang, Deric M Park
Atypical and anaplastic meningiomas (AAM) represent 20% of all meningiomas. They are associated with poor outcomes due to their tendency to recur. While surgery and radiation (RT) are first line therapy, no effective systemic medical treatment has been identified. Protein phosphatase 2A (PP2A) is a ubiquitously expressed serine/threonine phosphatase involved in cell cycle regulation and DNA repair. Here, we examined radiosensitizing effects of LB-100, a novel inhibitor of PP2A against AAM as a novel treatment strategy...
November 30, 2017: Cancer Letters
https://www.readbyqxmd.com/read/29193095/real-time-detection-system-for-tumor-localization-during-minimally-invasive-surgery-for-gastric-and-colon-cancer-removal-in-vivo-feasibility-study-in-a-swine-model
#18
Won Jung Choi, Jin-Hee Moon, Jae Seok Min, Yong Keun Song, Seung A Lee, Jin Woo Ahn, Sang Hun Lee, Ha Chul Jung
BACKGROUND AND OBJECTIVES: During minimally invasive surgery (MIS), it is impossible to directly detect marked clips around tumors via palpation. Therefore, we developed a novel method and device using Radio Frequency IDentification (RFID) technology to detect the position of clips during minimally invasive gastrectomy or colectomy. METHODS: The feasibility of the RFID-based detection system was evaluated in an animal experiment consisting of seven swine. The primary outcome was to successfully detect the location of RFID clips in the stomach and colon...
November 28, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29191500/3t-non-injected-phase-contrast-mri-sequences-for-the-mapping-of-the-external-carotid-branches-in%C3%A2-vivo-radio-anatomical-pilot-study-for-feasibility-analysis
#19
Jérémie Bettoni, Gwénaël Pagé, Anne-Virginie Salsac, Jean-Marc Constans, Sylvie Testelin, Bernard Devauchelle, Olivier Balédent, Stéphanie Dakpé
An essential stage in head and neck microsurgical reconstruction is the choice of recipient vessels. To make relevant choices, surgeons must rely on accurate imaging techniques. The objective of the study was to examine the feasibility of Phase-Contrast sequences to conduct the pre-operative tests without injection and provide precise radio-anatomical data over the entire vessel region. The challenges were the large velocity range, the lack of contrast, and the large spatial resolution needed to image vessels below 5 mm in diameter...
October 16, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/29187920/-benign-tumors-of-the-breast-in-the-department-of-senology-at-the-university-hospital-aristide-le-dantec-dakar-senegal
#20
Serigne Modou Kane Gueye, Mamour Gueye, Mariétou Thiam Coulibaly, Diana Mahtouk, Jean Charles Moreau
Introduction: This study aimed to identify the epidemiological, clinical and therapeutic features of benign tumors of the breast treated in the department of senology at the university hospital Aristide Le Dantec, Dakar. Methods: We conducted a cross-sectional, descriptive and analytical study of 220 patients treated in the Department of Senology at the University Hospital Aristide Le Dantec, Dakar over the period from 1 January 2008 to 31 December 2013. Results: 220 patients out of 984 consultants had benign tumor of the breast (22...
2017: Pan African Medical Journal
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