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https://www.readbyqxmd.com/read/28337635/measurement-of-bovine-body-and-scrotal-temperature-using-implanted-temperature-sensitive-radio-transmitters-data-loggers-and-infrared-thermography
#1
A L Wallage, J B Gaughan, A T Lisle, L Beard, C W Collins, S D Johnston
Synchronous and continuous measurement of body (BT) and scrotal temperature (ST) without adverse welfare or behavioural interference is essential for understanding thermoregulation of the bull testis. This study compared three technologies for their efficacy for long-term measurement of the relationship between BT and ST by means of (1) temperature sensitive radio transmitters (RT), (2) data loggers (DL) and (3) infrared imaging (IRI). After an initial pilot study on two bulls to establish a surgical protocol, RTs and DLs were implanted into the flank and mid-scrotum of six Wagyu bulls for between 29 and 49 days...
March 23, 2017: International Journal of Biometeorology
https://www.readbyqxmd.com/read/28332062/diagnosis-and-treatment-of-metastases-to-the-thyroid-gland-a-meta-analysis
#2
REVIEW
Patrizia Straccia, Claudia Mosseri, Chiara Brunelli, Esther Diana Rossi, Celestino Pio Lombardi, Alfredo Pontecorvi, Guido Fadda
The thyroid is a rare site of clinically detectable tumor metastases; even though the gland is a highly vascularized structure, the frequency of metastases in the routine practice is less than 0.2% of all thyroid malignancies. The purpose of our meta-analysis is to evaluate the frequency of metastatic diffusion from other primary tumors to the thyroid gland and to suggest the best possible treatment through an evidence-based study. Relevant studies were identified by searching the following databases: PubMed, Scopus, and Web of Science...
March 22, 2017: Endocrine Pathology
https://www.readbyqxmd.com/read/28331145/modified-marionette-technique-for-laparoscopic-colorectal-surgery
#3
Seiichi Shinji, Hayato Kan, Takeshi Yamada, Michihiro Koizumi, Aya Yamagishi, Yasuyuki Yokoyama, Goro Takahashi, Takuma Iwai, Keisuke Hara, Kohki Takeda, Keiichiro Ohta, Eiji Uchida
INTRODUCTION: Single-port laparoscopic surgery has some technical limitations with respect to control of the forceps inserted through the single-access site, which results in increased internal collisions due to coaxial alignment of the instruments, as well as and decreased range of motion and visualization. To overcome these limitations, we employ a "modified marionette technique" as a way to carry out laparoscopic colorectal surgery. Materials and Surgical Technique: The procedures for the modified marionette technique are performed as follows: An Internal Organ Retractor (IOR)™ and an atraumatic clip designed to firmly grasp tissue, with 1-0 nylon thread, are inserted through a 12-mm trocar and secured in place where adequate visualization and traction for cutting with a radio knife is required...
2017: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
https://www.readbyqxmd.com/read/28325631/new-concepts-of-personalized-therapy-in-salivary-gland-carcinomas
#4
REVIEW
Gunter Keller, Diana Steinmann, Alexander Quaas, Viktor Grünwald, Stefan Janssen, Kais Hussein
Salivary gland carcinomas are rare tumours and therapy strategies are less standardized than in lung, gastric or breast cancer. Therapy is based on surgery, but not all carcinomas are completely resectable, e.g. because carcinomas often show infiltration of nerves. For further therapy decision pathology is recommended, but evaluation of potential targets for personalized therapy is not part of the routine panel. Many salivary gland carcinomas can be resistant to radio- and/or chemotherapy, which limits therapeutic options...
March 18, 2017: Oral Oncology
https://www.readbyqxmd.com/read/28319639/changes-in-swallowing-after-anterior-cervical-discectomy-and-fusion-with-instrumentation-a-presurgical-versus-postsurgical-videofluoroscopic-comparison
#5
Lydia Muss, Janina Wilmskoetter, Kerstin Richter, Constanze Fix, Soenke Stanschus, Tobias Pitzen, Joerg Drumm, Sonja Molfenter
Purpose: The purpose of this study was to explore the impact of anterior cervical discectomy and fusion (ACDF) with anterior instrumentation on swallowing function and physiology as measured on videofluoroscopic swallowing studies. Method: We retrospectively analyzed both functional measures (penetration-aspiration, residue) and physiological/anatomical measures (hyoid excursion, posterior pharyngeal wall thickness) in a series of 17 patients (8 men, 9 women, mean age 54 years)...
March 20, 2017: Journal of Speech, Language, and Hearing Research: JSLHR
https://www.readbyqxmd.com/read/28315948/-18f-fmiso-pet-study-of-hypoxia-in-gliomas-before-surgery-correlation-with-molecular-markers-of-hypoxia-and-angiogenesis
#6
Lien Bekaert, Samuel Valable, Emmanuèle Lechapt-Zalcman, Keven Ponte, Solène Collet, Jean-Marc Constans, Guénaëlle Levallet, Karim Bordji, Edwige Petit, Pierre Branger, Evelyne Emery, Alain Manrique, Louisa Barré, Myriam Bernaudin, Jean-Sébastien Guillamo
PURPOSE: Hypoxia in gliomas is associated with tumor resistance to radio- and chemotherapy. However, positron emission tomography (PET) imaging of hypoxia remains challenging, and the validation of biological markers is, therefore, of great importance. We investigated the relationship between uptake of the PET hypoxia tracer [18F]-FMISO and other markers of hypoxia and angiogenesis and with patient survival. PATIENTS AND METHODS: In this prospective single center clinical study, 33 glioma patients (grade IV: n = 24, III: n = 3, and II: n = 6) underwent [18F]-FMISO PET and MRI including relative cerebral blood volume (rCBV) maps before surgery...
March 18, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28301088/survival-benefit-of-intravenous-and-intraperitoneal-paclitaxel-with-s-1-in-pancreatic-ductal-adenocarcinoma-patients-with-peritoneal-metastasis-a-retrospective-study-in-a-single-institution
#7
Sohei Satoi, Hiroaki Yanagimoto, Tomohisa Yamamoto, Satoshi Hirooka, So Yamaki, Hisashi Kosaka, Kentaro Inoue, Yuki Hashimoto, Yoichi Matsui, Masanori Kon
PURPOSE: We evaluated the clinical efficacy of intravenous (i.v.) and intraperitoneal (i.p.) paclitaxel (PTX) combined with S-1 in patients with chemotherapy-naïve pancreatic ductal adenocarcinoma (PDAC) with peritoneal metastasis. METHODS: Forty-nine patients were diagnosed with peritoneal metastasis during 2007-2014; 29 received gemcitabine or S-1 based chemo(radio)therapy from 2007-11 (control group), and the remaining 20 received i.v. (50 mg/m(2) ) and i.p...
March 16, 2017: Journal of Hepato-biliary-pancreatic Sciences
https://www.readbyqxmd.com/read/28291492/telesurgery-with-miniature-robots-to-leverage-surgical-expertise-in-distributed-expeditionary-environments
#8
Mark Reichenbach, Tom Frederick, Lou Cubrich, Walter Bircher, Nathan Bills, Marsha Morien, Shane Farritor, Dmitry Oleynikov
This study aimed to evaluate the capability of performing telesurgery via radio transmission for military arenas where wired internet connections may not be practical. Most existing robotic surgery systems are too large to effectively deploy with first responders. The miniature surgical platform in this study consists of a multifunctional robot suite that can fit easily into a briefcase. METHODS: The focus of this study is to explore the implications of radio control of the robot. The hypothesis is that an in vivo robot and its control boards can be controlled using off-the-shelf wireless components...
March 2017: Military Medicine
https://www.readbyqxmd.com/read/28281769/long-term-surgical-anaesthesia-with-isoflurane-in-human-habituated-nile-crocodiles
#9
George F Stegmann, Catherine J A Williams, Craig Franklin, Tobias Wang, Michael Axelsson
A suitable long-term anaesthetic technique was required for implantation of physiological sensors and telemetric devices in sub-adult Nile crocodiles (Crocodylus niloticus) to allow the collection of physiological data. Five Nile crocodiles with a median body mass of 24 kg were used. After manual capture, they were blindfolded and 0.2 mL (1 mg/mL) medetomidine was administered intramuscularly in four of the animals which had an estimated body mass between 20 kg and 30 kg. One crocodile with an estimated body mass of 50 kg received 0...
February 24, 2017: Journal of the South African Veterinary Association
https://www.readbyqxmd.com/read/28276825/perioperative-chemotherapy-for-resectable-gastric-cancer-what-is-the-evidence
#10
Erling A Bringeland, Hans H Wasmuth, Jon E Grønbech
The UK MAGIC trial published in 2006 was the first RCT to identify improved long-term survival rates using preoperative chemotherapy for resectable gastric or gastroesophageal cancer. Overnight, the treatment regimen impacted European guidelines. However, the majority of patients underwent limited lymph node dissection, and analyses of the rates of curative resection, downsizing and downstaging were not by intention to treat, rightfully raising concerns about their validity. For the subset of true gastric cancers, meta-analyses may even question the claims of improved long-term survival rates by present-day regimens...
February 28, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/28272005/bilateral-breast-cancer-after-prophylactic-bilateral-pulmonary-irradiation
#11
Hamrouni A El Meddeb, Jebsi M Chehata, S Kanoun, C Rancoule, J B Guy, N Magne, N Bouaouina
The purpose of this article is to report a new case of a probably radio-induced bilateral breast cancer occurred after prophylactic bilateral pulmonary irradiation in the treatment of osteosarcoma. A 42-year-old woman, treated at the age of 12 years for osteosarcoma at the right lower limb with chemotherapy (methotrexate, adriamycin and cisplatin) followed by non-conservative surgery and adjuvant radiotherapy. Eighteen years after, she developed her first breast cancer, and five years later, her second contralateral breast cancer...
January 2017: Gulf Journal of Oncology
https://www.readbyqxmd.com/read/28270132/effects-of-the-lysosomal-destabilizing-drug-siramesine-on-glioblastoma-in-vitro-and-in-vivo
#12
Stine S Jensen, Stine A Petterson, Bo Halle, Charlotte Aaberg-Jessen, Bjarne W Kristensen
BACKGROUND: Glioblastoma is the most frequent and most malignant brain tumor with the patients having a median survival of only 14.6 months. Although glioblastoma patients are treated with surgery, radiation and chemotherapy recurrence is inevitable. A stem-like population of radio- and chemoresistant brain tumor-initiating cells combined with the invasive properties of the tumors is believed to be critical for treatment resistance. In the present study, the aim was to investigate the effect of a novel therapeutic strategy using the lysosomotropic detergent siramesine on glioblastomas...
March 7, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28268349/characterization-of-thrombus-stiffening-in-radio-frequency-rf-mechanical-thrombectomy
#13
Chris C H Chon, Jack Z Qin, John C K Kwok, David C C Lam
Intra-arterial mechanical thrombectomy (IAMT) for ischemic stroke has high recanalization rate, long treatment time window and low risk of symptomatic intracerebral haemorrhage (sICH), but thrombus fragments produced during treatment can lead to distal embolization. Fragmentation can be reduced if the thrombus is strengthened by increasing the thrombus's crosslink density. Radio frequency (rf) electric current commonly used in surgery to cut and coagulate tissue can induce crosslinking in thrombus. The increase in thrombus stiffness as a result of the increase in crosslinking from rf treatment is characterized in this study...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28247946/the-emerging-role-of-exosome-and-microvesicle-emv-based-cancer-therapeutics-and-immunotherapy
#14
REVIEW
Colin Moore, Uchini Kosgodage, Sigrun Lange, Jameel M Inal
There is an urgent need to develop new combination therapies beyond existing surgery, radio- and chemo-therapy, perhaps initially combining chemotherapy with the targeting specificities of immunotherapy. For this, strategies to limit inflammation and immuno-suppression and evasion in the tumour microenvironment are also needed. To devise effective new immunotherapies we must first understand tumour immunology, including the roles of T cells, macrophages, myeloid suppressor cells and of exosomes and microvesicles (EMVs) in promoting angiogenesis, tumour growth, drug resistance and metastasis...
March 1, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28243959/mirnas-as-biomarkers-and-therapeutic-targets-in-non-small-cell-lung-cancer-current-perspectives
#15
Mateusz Florczuk, Adam Szpechcinski, Joanna Chorostowska-Wynimko
Lung cancer is the most common cancer worldwide. Up to 85% of lung cancer cases are diagnosed as non-small cell lung cancer (NSCLC). The effectiveness of NSCLC treatment is expected to be improved through the implementation of robust and specific biomarkers. MicroRNAs (miRNAs) are small, non-coding molecules that play a key role in the regulation of basic cellular processes, including differentiation, proliferation and apoptosis, by controlling gene expression at the post-transcriptional level. Deregulation of miRNA activity results in the loss of homeostasis and the development of a number of pathologies, including lung cancer...
February 27, 2017: Targeted Oncology
https://www.readbyqxmd.com/read/28240521/morphological-classification-of-intraductal-papillary-neoplasm-of-the-bile-duct-with-survival-correlation
#16
Vor Luvira, Kulyada Somsap, Ake Pugkhem, Chalerm Eurboonyanun, Varisara Luvira, Vajarabhongsa Bhudhisawasdi, Chawalit Pairojkul, Supot Kamsa Ard
Background: Intraductal papillary neoplasm of the bile duct (IPNB) is a specific entity for which there has been no classification that correlates clinical presentation with patient survival. We, therefore, propose a new classification based on radio-pathological appearance correlated with clinical findings including outcome. Methods: We retrospectively reviewed the medical and pathological records of 103 IPNB patients who underwent curative-intent hepatic resection between January 2008 and December 2011. A morphological classification was then created based on the presence of (a) bile duct dilatation, (b) intraductal mass(es), (c) cystic lesion(s), and (d) macro-invasion of the liver...
January 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28239999/glioblastoma-multiforme-a-review-of-its-epidemiology-and-pathogenesis-through-clinical-presentation-and-treatment
#17
Farina Hanif, Kanza Muzaffar, Kahkashan Perveen, Saima M Malhi, Shabana U Simjee
Glioblastoma multiforme (GBM) is one of the most malignant types of central nervous system tumors. Despite advances in treatment modalities it remains largely incurable. The objective of our review is to provide a holistic picture of GBM epidemiology, etiology, pathogenesis, clinical findings and treatment. A literature search was conducted for GBM at PubMed and Google Scholar, with relevant key words like glioblastoma multiforme, pathogenesis, signs and symptoms, treatment etc., and papers published until 2015 were reviewed...
January 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28238560/diagnostic-and-therapeutic-modalities-for-287-malignant-and-benign-salivary-tumors-a-cohort-study
#18
Yair Israel, Adi Rachmiel, Gil Ziv, Rafael Nagler
BACKGROUND: Salivary gland tumors (SGT's), 3-10% of head/neck tumors, exhibit a striking range of morphological diversity. This minimally symptomatic disease can be challenging to diagnose, and therapeutic policy is still controversial. METHODS: We compared benign and malignant cohorts according to diagnostic modality utilized and therapeutic modality administered over 20 years in a single medical center. RESULTS: Of 287 cases, 216 had benign tumors and 71 had malignant tumors...
January 25, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28231577/response-evaluation-in-head-and-neck-oncology-definition-and-prediction
#19
T K Hoffmann, P J Schuler, S Laban, R Grässlin, M Beer, A J Beer, U Friebe-Hoffmann, L Bullinger, P Möller, T Wiegel
Curative treatment of head and neck squamous cell carcinoma includes surgery and/or (chemo)radiation, whereas in the palliative setting, chemotherapy and/or immunotherapy represent(s) the standard approach. With regard to quality control, methods for determining treatment response are sorely needed. For surgical therapy, histopathology is the standard quality control. Established criteria for high-risk patients include resection margins of the primary tumor and extracapsular extension of lymph node metastases...
2017: ORL; Journal for Oto-rhino-laryngology and its related Specialties
https://www.readbyqxmd.com/read/28226511/characterization-of-thrombus-stiffening-in-radio-frequency-rf-mechanical-thrombectomy
#20
Chris C H Chon, Jack Z Qin, John C K Kwok, David C C Lam, Chris C H Chon, Jack Z Qin, John C K Kwok, David C C Lam, David Cc Lam, Chris Ch Chon, John Ck Kwok, Jack Z Qin
Intra-arterial mechanical thrombectomy (IAMT) for ischemic stroke has high recanalization rate, long treatment time window and low risk of symptomatic intracerebral haemorrhage (sICH), but thrombus fragments produced during treatment can lead to distal embolization. Fragmentation can be reduced if the thrombus is strengthened by increasing the thrombus's crosslink density. Radio frequency (rf) electric current commonly used in surgery to cut and coagulate tissue can induce crosslinking in thrombus. The increase in thrombus stiffness as a result of the increase in crosslinking from rf treatment is characterized in this study...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
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