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https://www.readbyqxmd.com/read/29769143/clinical-outcome-of-elderly-patients-%C3%A2-70-years-with-esophageal-cancer-undergoing-definitive-or-neoadjuvant-radio-chemo-therapy-a-retrospective-single-center-analysis
#1
Franziska Walter, David Böckle, Nina-Sophie Schmidt-Hegemann, Rebecca Köpple, Sabine Gerum, Stefan Boeck, Martin Angele, Claus Belka, Falk Roeder
BACKGROUND: To analyse the outcome of elderly patients (≥70 years) with esophageal cancer treated with curative intent radio(chemo)therapy. METHODS: Fifty five patients (median 75 years) receiving curative intent radio(chemo)therapy for esophageal cancer from 1999 to 2015 were retrospectively analyzed. Most patients showed locally advanced disease (T3/4:78%, N+:58%) with squamous cell histology (74%). Charlson comorbidity score was > 1 in 27%. 48 patients (87%) received definitive treatment while 7 patients were treated neoadjuvantly...
May 16, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29767284/diagnostic-accuracy-of-mri-in-assessing-tumor-regression-and-identifying-complete-response-in-patients-with-locally-advanced-rectal-cancer-after-neoadjuvant-treatment
#2
Medhat Aker, Darren Boone, Anuradha Chandramohan, Bruce Sizer, Roger Motson, Tan Arulampalam
BACKGROUND: The diagnostic accuracy of Magnetic Resonance Imaging (MRI) in restaging locally advanced rectal cancers (LARC) after neoadjuvant chemo-radio therapy (NCRT) has been under recent scrutiny. There is limited data on the accuracy of MRI and its timing in assessing tumor regression grade (TRG) and in identifying patients with complete response (CR). NCRT seems to cause tissue inflammation and oedema which renders reading the scans difficult for radiologist. AIM: This study aims to assess the accuracy of MRI at different time intervals after NCRT in staging TRG and in identifying CR...
May 16, 2018: Abdominal Radiology
https://www.readbyqxmd.com/read/29764016/-a-retrospective-study-on-combined-modality-therapy-with-or-without-surgery-for-advanced-hypopharyngeal-squamous-cell-carcinoma-an-analysis-of-119-cases
#3
Y X Zhang, H H Peng, X X Zhang, J D Zhao, W M Wu, J L Wang, D L Huang, L Zong, L W Chen, C Q Liu, M B Liu
Objective: To compare the treatment outcomes for locally advanced hypopharyngeal carcinoma between surgery plus radio(chemo) therapy(SRT) and non-surgery chemoradiotherapy(CRT). Methods: A total of 119 patients diagnosed with advanced hypopharyngeal carcinoma without distant metastases between 2010 and 2014 were identified in the Chinese People's Liberation Army General Hospital, and they were divided into 2 groups: 42 cases in SRT group and 77 cases in CRT group. Patients' clinical information was collected...
May 7, 2018: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/29737379/a-simple-method-to-locate-mandibular-foramen-with-cone-beam-computed-tomography-and-its-relevance-to-oral-and-maxillofacial-surgery-a-radio-anatomical-study
#4
Mohammad H Al-Shayyab
PURPOSE: The mandibular foramen (MF) cannot be palpated clinically and its location is variable at the medial surface of mandibular ramus. Nevertheless, determining its exact location is very important to the oral and maxillofacial surgeon for the relevant anesthetic and surgical ramus procedures. The aim of this study was to analyze the position of MF using cone-beam computed tomography (CBCT) to help the surgeon in identifying reliable 'target area' for the inferior alveolar nerve (IAN) block and 'safety zone' for mandibular ramus osteotomies approached extra-orally...
May 8, 2018: Surgical and Radiologic Anatomy: SRA
https://www.readbyqxmd.com/read/29733987/use-of-bone-morphogenetic-protein-2-in-vertebral-column-tumor-surgery-a-national-investigation
#5
Rafael De la Garza Ramos, Jonathan Nakhla, Murray Echt, Yaroslav Gelfand, David J Altschul, Woojin Cho, Merrit D Kinon, Reza Yassari
OBJECTIVE: To report the rate of bone morphogenetic protein-2 (BMP-2) use in vertebral column tumor surgery. METHODS: The Nationwide Inpatient Sample database (2012-2014) was queried to identify patients who underwent spinal fusion for vertebral column tumors (primary benign, primary malignant, or metastatic). The rate of BMP-2 use was calculated and patient/operative factors associated with its use were also investigated. RESULTS: A total of 9,375 patients who underwent fusion surgery for spinal tumors between 2012 and 2014 were identified, with 540 cases using BMP-2 (5...
May 4, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29719480/nuclear-medicine-in-prostate-cancer-a-new-era-for-radiotracers
#6
REVIEW
Vincenzo Cuccurullo, Giuseppe Danilo Di Stasio, Luigi Mansi
Natural history of prostate cancer (PCa) is extremely variable, as it ranges from indolent and slow growing tumors to highly aggressive histotypes. Genetic background and environmental factors co-operate to the genesis and clinical manifestation of the tumor and include among the others race, family, specific gene variants (i.e., BRCA1 and BRCA2 mutations), acute and chronic inflammation, infections, diet and drugs. In this scenario, remaining actual the clinical interest of bone scan (BS) in detecting skeletal metastases, an important role in diagnostic imaging may be also carried out by, positron emission tomography/computed tomography (PET/CT) and PET/magnetic resonance imaging (PET/MRI), which combine morphological information provided by CT and MRI with functional and metabolic data provided by PET acquisitions...
April 2018: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29717261/antagonizing-cd105-enhances-radiation-sensitivity-in-prostate-cancer
#7
Anisha Madhav, Allen Andres, Frank Duong, Rajeev Mishra, Subhash Haldar, Zhenqiu Liu, Bryan Angara, Roberta Gottlieb, Zachary S Zumsteg, Neil A Bhowmick
Radiation therapy is the primary intervention for nearly half of the patients with localized advanced prostate cancer and standard of care for recurrent disease following surgery. The development of radiation-resistant disease is an obstacle for nearly 30-50% of patients undergoing radiotherapy. A better understanding of mechanisms that lead to radiation resistance could aid in the development of sensitizing agents to improve outcome. Here we identified a radiation-resistance pathway mediated by CD105, downstream of BMP and TGF-β signaling...
May 2, 2018: Oncogene
https://www.readbyqxmd.com/read/29715573/primary-ewing-sarcoma-of-frontotemporal-bone-in-a-geriatric-patient-case-report
#8
Seckin Aydin, Odhan Yuksel, Rahime Tanritanir, Aysegul Esen Aydin, Suat Erol Celik
Ewing sarcoma is a rare primary malignant bone tumor which mainly effects children and adolescents. Calvarial bone involvement and its appearance in elder patients are extremely rare. We presented a 68 years old female patient with headache and right frontotemporal swelling. Imaging studies showed a right frontotemporal mass expanding to Sylvian fissure. The patient underwent total resection of the mass and pathological evaluation ensured the diagnosis of primary Ewing sarcoma. Patient had adjuvant radio- and chemotherapy after surgery...
April 28, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29707301/lymph-node-metastases-near-the-celiac-trunk-should-be-considered-separately-from-other-nodal-metastases-in-patients-with-cancer-of-the-esophagus-or-gastroesophageal-junction-after-neoadjuvant-treatment-and-surgery
#9
Sjoerd M Lagarde, Martinus C J Anderegg, Suzanne S Gisbertz, Sybren L Meijer, Maarten C C M Hulshof, Jacques J G H M Bergman, Hanneke W M van Laarhoven, Mark I van Berge Henegouwen
Background: The aim of the present study is to identify the incidence and prognostic significance of lymph node metastases near the celiac trunk in patients who underwent neoadjuvant chemo(radio)therapy followed by esophagectomy. Methods: Between March 1994 and September 2013 a total of 462 consecutive patients with cancer of the esophagus or gastroesophageal junction (GEJ) who underwent potentially curative esophageal resection after neoadjuvant chemotherapy (N=88; 19...
March 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29704772/mass-spectrometry-characterization-of-dota-nimotuzumab-conjugate-as-precursor-of-an-innovative-%C3%AE-tracer-suitable-in-radio-guided-surgery
#10
Claudia Martelli, Valeria Marzano, Federica Marini, Teresa Scotognella, Ilaria Fratoddi, Iole Venditti, Dante Rotili, Elena Solfaroli-Camillocci, Francesco Collamati, Carlo Mancini-Terracciano, Silvio Morganti, Daria Maccora, Riccardo Faccini, Antonella Cartoni, Alessandro Giordano, Massimo Castagnola
The aim of the present work has been the mass spectrometry characterization of the Nimotuzumab (NIM) antibody chemically modified with the bifunctional chelating agent para-S-2-(4-isothiocyanatobenzyl)-1,4,7,10-tetraaza cyclododecanetetraacetic acid (p-SCN-Bn-DOTA). The conjugate, upon labeling with the pure β- -emitter 90 Y3+ , could represent a promising candidate as radiotracer for an innovative radio-guided surgery (RGS) technique, developed and patented by researchers of our group, which uses a probe system for intraoperative detection of tumor residues exploiting the selective uptake of β- -emitting tracers...
March 12, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29696442/the-best-of-both-worlds-a-hybrid-approach-for-optimal-pre-and-intraoperative-identification-of-sentinel-lymph-nodes
#11
G H KleinJan, E van Werkhoven, N S van den Berg, M B Karakullukcu, H J M A A Zijlmans, J A van der Hage, B A van de Wiel, T Buckle, W M C Klop, S Horenblas, R A Valdés Olmos, H G van der Poel, F W B van Leeuwen
PURPOSE: Hybrid image-guided surgery technologies such as combined radio- and fluorescence-guidance are increasingly gaining interest, but their added value still needs to be proven. In order to evaluate if and how fluorescence-guidance can help realize improvements beyond the current state-of-the-art in sentinel node (SN) biopsy procedures, use of the hybrid tracer indocyanine green (ICG)-99m Tc-nancolloid was evaluated in a large cohort of patients. PATIENTS AND METHODS: A prospective trial was conducted (n = 501 procedures) in a heterogeneous cohort of 495 patients with different malignancies (skin malignancies, oral cavity cancer, penile cancer, prostate cancer and vulva cancer)...
April 25, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29687523/safety-of-anesthesia-for-children-with-mucopolysaccharidoses-a-retrospective-analysis-of-54-patients
#12
Vittorio Scaravilli, Alberto Zanella, Valentina Ciceri, Mariagrazia Bosatra, Claudia Flandoli, Alessia La Bruna, Simone Sosio, Rossella Parini, Serena Gasperini, Antonio Pesenti, Alessandra Moretto
BACKGROUND: Complications are common during anesthesia for patients with mucopolysaccharidoses. San Gerardo Hospital (Italy) is a reference center for mucopolysaccharidoses with a dedicated pediatric anesthesia service. AIMS: This study aims to evaluate the safety of anesthesia for mucopolysaccharidoses patients, describe their anesthetic management at our institution, and assess risk factors for complications. METHODS: The anesthetic charts of mucopolysaccharidoses patients admitted from January 1999 to December 2014 were retrospectively analyzed...
April 23, 2018: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/29685086/preoperative-localization-of-recurrence-in-the-thyroidectomy-bed-using-a-radioactive-iodine-125-seed
#13
Hillary W Garner, Ricardo Paz-Fumagalli, Geoffrey D Young
Intraoperative localization of nonpalpable recurrent thyroid cancer has been reported using needle localization, intraoperative ultrasound (US), dye injection, and radio-guided surgery. We describe the alternative technique of radioactive seed localization (RSL) in 3 patients with residual or recurrent papillary thyroid cancer. This technique has been used for many years in the setting of nonpalpable breast cancer, where it has been shown to be safe and has been associated with greater surgeon satisfaction as well as improved patient tolerability, cosmesis, and outcomes compared to needle localization...
April 1, 2018: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29681787/the-response-to-neoadjuvant-chemoradiotherapy-with-5-fluorouracil-in-locally-advanced-rectal-cancer-patients-a-predictive-proteomic-signature
#14
Anaïs Chauvin, Chang-Shu Wang, Sameh Geha, Perrine Garde-Granger, Alex-Ane Mathieu, Vincent Lacasse, François-Michel Boisvert
Background: Colorectal cancer is the third most common and the fourth most lethal cancer in the world. In the majority of cases, patients are diagnosed at an advanced stage or even metastatic, thus explaining the high mortality. The standard treatment for patients with locally advanced non-metastatic rectal cancer is neoadjuvant radio-chemotherapy (NRCT) with 5-fluorouracil (5-FU) followed by surgery, but the resistance rate to this treatment remains high with approximately 30% of non-responders...
2018: Clinical Proteomics
https://www.readbyqxmd.com/read/29680980/when-a-cure-becomes-the-pathology-mechanical-bowel-obstruction-due-to-herbal-pharmacobezoar-a-case-report-with-review-of-literature
#15
Saurabh Gandhi, Eham Arora, Ajay Bhandarwar, Arun Patil, Amol Wagh, Shubham Gupta
Bezoars are intra-luminal concretions of ingested material which accumulate within the bowel. They are termed pharmacobezoars when the constituent material is drugs. We report a 64-year-old female with abdominal pain and obstipation for 3 days. Patient had completed anti-tuberculous combination therapy for suspected abdominal tuberculosis 25 years ago. She exhibited features of shock with a right iliac fossa lump. Abdominal X-ray displayed multiple air-fluid levels with densely cluttered radio-opacities in the right lower quadrant...
April 21, 2018: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/29661986/maxillary-sinus-mucocele-with-orbital-complications
#16
Nicola Lombardo, Pierpaolo Ferrise, Giovanna Lucia Piazzetta, Donatella Bruzzichessi, Domenico Testa, Pasquale Viola, Corrado Pelaia, Gaetano Motta
INTRODUCTION: Maxillary sinus mucocele is an unusual clinic entity (incidence of 3-10%), represented by mucous secretion lined by respiratory stratified pavemented epithelium and its origin is mainly secondary to infections, inflammations, surgery, trauma or neoplasia. CASE REPORT: We present a case of maxillary sinus mucocele. Subject of the study is a 74 aged patient referring positive anamnesis for nasal cavity surgery. His symptoms appeared six months ago and he complainted vertical ocular diplopia and ocular tension sensation, without rhinologic complaints...
April 9, 2018: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/29659611/preoperative-evaluation-of-the-efficacy-of-radio-hyperthermo-chemotherapy-for-soft-tissue-sarcoma-in-a-case-series
#17
Hisaki Aiba, Satoshi Yamada, Jun Mizutani, Norio Yamamoto, Hideki Okamoto, Katsuhiro Hayashi, Hiroaki Kimura, Akihiko Takeuchi, Shinji Miwa, Takashi Higuchi, Kensaku Abe, Yuta Taniguchi, Yoshihiro Araki, Hiroyuki Tsuchiya, Takanobu Otsuka
PURPOSE: Radio-hyperthermo-chemo (RHC) therapy, which combines radiotherapy, hyperthermia, and chemotherapy, for malignant soft tissue tumors has been introduced with the aim of decreasing the possibility of local recurrence after surgery. To avoid unnecessary neoadjuvant therapy and to plan the appropriate surgical treatment, surveillance of RHC therapeutic efficacy during treatment is necessary. In this study, we determined the optimal response criteria to evaluate the efficacy of RHC by comparing preoperative images before and after RHC with pathological evaluation of necrosis in the resected tumor...
2018: PloS One
https://www.readbyqxmd.com/read/29643907/fixation-of-unstable-distal-radius-fractures-by-using-expandable-intramedullary-nailing-system-in-adult-patients
#18
Murat Calbiyik
Objective: To present our experience on intramedullary nailing device Sonoma Wrx (Sonoma Orthopedic Products Inc., Santa Rosa, CA, USA) used for internal fixation of extra-articular or simple intra-articular distal radius fractures in adult population. Methods: This study was conducted from February 2011 to October 2016. A total of 48 patients (mean age 47.3±5.6 years, 35.4% females) with distal radius fracture, who underwent intramedullary distal radius fixation by using Sonoma Wrx were included in this retrospective study...
January 2018: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/29643555/ultrasound-guided-internal-jugular-vein-cannulation-in-infants-comparative-evaluation-of-novel-modified-short-axis-out-of-plane-approach-with-conventional-short-axis-out-of-plane-approach
#19
Amit Rastogi, Aarti Agarwal, Puneet Goyal, Vansh Priya, Sanjay Dhiraaj, Rudrashish Haldar
Background and Aims: Central venous cannulation (CVC) through right internal jugular vein (IJV) route is routinely performed in paediatric patients undergoing major surgery and in those admitted to intensive care units. A novel technique (modified short-axis out-of-plane [MSA-OOP]) to improve first pass success rate of ultrasound-guided IJV CVC in neonates and infants is being compared with conventional SA-OOP method. Methods: A total of 120 patients were enroled in the study over a period of 6 months...
March 2018: Indian Journal of Anaesthesia
https://www.readbyqxmd.com/read/29615917/advances-in-glioblastoma-multiforme-treatment-new-models-for-nanoparticle-therapy
#20
REVIEW
Elif Ozdemir-Kaynak, Amina A Qutub, Ozlem Yesil-Celiktas
The most lethal form of brain cancer, glioblastoma multiforme, is characterized by rapid growth and invasion facilitated by cell migration and degradation of the extracellular matrix. Despite technological advances in surgery and radio-chemotherapy, glioblastoma remains largely resistant to treatment. New approaches to study glioblastoma and to design optimized therapies are greatly needed. One such approach harnesses computational modeling to support the design and delivery of glioblastoma treatment. In this paper, we critically summarize current glioblastoma therapy, with a focus on emerging nanomedicine and therapies that capitalize on cell-specific signaling in glioblastoma...
2018: Frontiers in Physiology
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