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https://www.readbyqxmd.com/read/28537901/inflammatory-cytokines-are-associated-with-response-and-prognosis-in-patients-with-esophageal-cancer
#1
Susanne Blank, Henrik Nienhüser, Lena Dreikhausen, Leila Sisic, Ulrike Heger, Katja Ott, Thomas Schmidt
BACKGROUND: Esophageal cancer is often marked by aggressive tumor growth and poor prognosis. Patient groups who benefit from perioperative therapy are not yet defined. The tumor microenvironment and circulating factors as possible predictors of response and prognosis gain interest. This study aimed to investigate cytokines in patients' serum and tumor tissue with regard to response and prognosis. RESULTS: Median survival between SCC and AC was not different (published previously)...
May 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/28512411/spinal-intradural-intramedullary-dissemination-in-the-absence-of-intracranial-relapse-of-a-previously-radically-treated-temporal-lobe-glioblastoma-multiforme
#2
Lucas Serrano, Eleftherios Archavlis, Elke Januschek, Pavel Timofeev, Peter Ulrich
Intracranial glioblastoma multiforme (GBM) constitutes the most frequent and unfortunately aggressive primary central nervous system malignancy. Despite the high tendency of these tumors to show local relapse within the brain after primary therapy, dissemination into the spinal axis is an infrequent event. If spinal metastases occur they are leptomeningeal in the vast majority of cases and always in the context of intracranial progressive disease. Spinal intramedullary metastases of intracranial GBM have rarely been described to date...
January 2017: Case Reports in Oncology
https://www.readbyqxmd.com/read/28506419/radioguided-thyroidectomy-for-follicular-tumors-multicentric-experience
#3
D Parmeggiani, C Gambardella, R Patrone, A Polistena, M De Falco, R Ruggiero, R Cirocchi, A Sanguinetti, V Cuccurullo, M Accardo, N Avenia, G Docimo, S Tolone, V Bassi, L Docimo, G Conzo
BACKGROUND: The diagnosis of thyroid nodular diseases requires an integrated approach that has been widely established over the past years. This strategy includes: ultrasonography (US) with; implemented Color-Power-Doppler, conventional scintigraphy also with positive indicators, specific pathological studies targeted by immunohistochemically-assays, and the fine needle; aspiration biopsy (FNAB), which, usually, in case of "Follicular Lesions" (10-20%) findings is; unable to distinguish carcinoma from follicular adenoma, then indicating the necessity of surgery to; obtain a correct diagnosis...
May 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28500597/blood-pressure-monitoring-using-radio-telemetry-method-in-mice
#4
Yu Wang, Sean E Thatcher, Lisa A Cassis
The TA11PA-C10 implantable transmitter (Data Sciences International, DSI) is designed to measure blood pressure (BP) and activity in freely moving laboratory mice. The fluid filled catheter is placed in the free flowing blood of the systemic artery (inserted into the left carotid artery and extended into the aorta), and the transmitter body is placed in a benign location for long-term biocompatibility. The transmitter can be used to monitor BP in mice (as small as 17 g) under normal physiological and unrestricted conditions 24 h a day while remaining free from stress associated with human interaction...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28499389/a-phase-ii-trial-of-autologous-dendritic-cell-vaccination-and-radiochemotherapy-following-fluorescence-guided-surgery-in-newly-diagnosed-glioblastoma-patients
#5
Susana Inogés, Sonia Tejada, Ascensión López-Díaz de Cerio, Jaime Gállego Pérez-Larraya, Jaime Espinós, Miguel Angel Idoate, Pablo Daniel Domínguez, Reyes García de Eulate, Javier Aristu, Maurizio Bendandi, Fernando Pastor, Marta Alonso, Enrique Andreu, Felipe Prósper Cardoso, Ricardo Díez Valle
BACKGROUND: Prognosis of patients with glioblastoma multiforme (GBM) remains dismal, with median overall survival (OS) of about 15 months. It is therefore crucial to search alternative strategies that improve these results obtained with conventional treatments. In this context, immunotherapy seems to be a promising therapeutic option. We hypothesized that the addition of tumor lysate-pulsed autologous dendritic cells (DCs) vaccination to maximal safe resection followed by radiotherapy and concomitant and adjuvant temozolomide could improve patients' survival...
May 12, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/28498880/a-two-arm-multicenter-phase-ii-trial-of-one-cycle-chemoselection-split-dose-docetaxel-cisplatin-and-5-fluorouracil-tpf-induction-chemotherapy-before-two-cycles-of-split-tpf-followed-by-curative-surgery-combined-with-postoperative-radiotherapy-in-patients-with
#6
J Inhestern, H Schmalenberg, A Dietz, N Rotter, G Maschmeyer, M Jungehülsing, C Grosse-Thie, T Kuhnt, M Görner, H Sudhoff, C Wittekindt, O Guntinas-Lichius
Background: : Induction chemotherapy (ICT) with docetaxel, cisplatin and fluorouracil (TPF) followed by radiotherapy is an effective treatment option for locally advanced head and neck cancer. This phase II study investigated the effectivity of a split-dose TPF ICT prior to surgery for locally advanced resectable (stage III/IVA) oral and oropharyngeal cancer. Patients and methods: : Patients received TPF split on two dosages on day 1 and 8 per cycle (30 mg/m 2 docetaxel, 40 mg/m 2 cisplatin, 2000 mg/m 2 fluorouracil per week)...
May 11, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28497194/treatment-and-outcomes-of-recurrent-hepatocellular-carcinomas
#7
Gaëtan-Romain Joliat, Pierre Allemann, Ismail Labgaa, Nicolas Demartines, Nermin Halkic
PURPOSE: Surgery is one of the best options for curative treatment of hepatocellular carcinomas (HCC). Recurrences are nevertheless common (45-75%). This study aimed to compare overall survival (OS) of patients with recurrent HCC after primary resection to OS of patients without recurrence. METHODS: A retrospective review of all HCC patients operated between 1993 and 2015 was performed. Median and 5-year OS were calculated. RESULTS: This study included 147 HCC patients...
May 11, 2017: Langenbeck's Archives of Surgery
https://www.readbyqxmd.com/read/28478739/translocation-renal-cell-carcinoma-in-a-child-previously-treated-for-infantile-fibrosarcoma
#8
Jing Ma, Ci Pan, Minzhi Yin
We report a child who developed a TFE3/Xp11.2 translocation renal cell carcinoma (RCC) when he was 3 years and 3 months old, after previous treatment for infantile fibrosarcoma (IFS). When he was 3 months old, a left axilla mass has been detected, which was tan and solid, was 1.5 cm in greatest dimension, and composed of sheets of spindle cells that was positive for vimentin and fibronectin. Fluorescence in situ hybridization showed positive result in ETV6 gene rearrangements. The final diagnosis was IFS...
January 1, 2017: Pediatric and Developmental Pathology
https://www.readbyqxmd.com/read/28476125/performance-of-claims-based-algorithms-for-identifying-incident-thyroid-cancer-in-commercial-health-plan-enrollees-receiving-antidiabetic-drug-therapies
#9
Donnie Funch, Douglas Ross, Betsey M Gardstein, Heather S Norman, Lauren A Sanders, Atheline Major-Pedersen, Helge Gydesen, David D Dore
BACKGROUND: Thyroid cancer incidence is increasing in the United States (US) and many other countries. The objective of this study was to develop and evaluate algorithms using administrative medical claims data for identification of incident thyroid cancer. METHODS: This effort was part of a prospective cohort study of adults initiating therapy on antidiabetic drugs and used administrative data from a large commercial health insurer in the US. Patients had at least 6 months of continuous enrollment prior to initiation during 2009-2013, with follow-up through March, 2014 or until disenrollment...
May 5, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28473231/arthroscopic-reconstruction-for-unstable-scaphoid-non-union
#10
P J Delgado-Serrano, I Jiménez-Jiménez, M Nikolaev, F A Figueredo-Ojeda, M Gil de Rozas-López
OBJECTIVE: To evaluate the results of arthroscopic reconstruction for the treatment of unstable scaphoid non-union with cancellous bone autograft. METHODS: 13 patients were treated with a mean age of 26 (18-45) years. The average time from injury until surgery was 14 (6-48) months. Preoperative and postoperative clinical and radiological parameters were evaluated. Mean follow-up was 16.8 (12-36) months. RESULTS: Consolidation was achieved in all cases at 7 (4-10 weeks), no patient had complications or reoperations...
May 1, 2017: Revista Española de Cirugía Ortopédica y Traumatología
https://www.readbyqxmd.com/read/28471547/-comprehensive-therapeutic-strategy-for-localized-esophageal-cancer-second-part-interest-of-multimodal-approaches-with-or-without-surgery
#11
D Van Daele, P Honoré, J Collignon, M Polus, C Loly, E Mutijima, A De Roover, P A Coucke, E Louis, P Martinive
In recent years, the treatment of esophagus cancer has been completely changed, thus competing the dogma of surgery as the cornerstone treatment. Multimodality treatments as radio-chemotherapy directly followed by surgery, or delayed surgery, significantly improve patient survival compared to surgery alone. Neoadjuvant radiochemotherapy is associated with a higher complete pathologic response rate and improved survival compared to chemotherapy alone. Immediate surgery after radio-chemotherapy is challenged for patients who present a complete clinical response, especially in case of squamous cell carcinoma...
April 2017: Revue Médicale de Liège
https://www.readbyqxmd.com/read/28462406/effectiveness-of-radio-waves-application-in-modern-general-dental-procedures-an-update
#12
Arslan Qureshi, Sergio Varela Kellesarian, Michael A Pikos, Fawad Javed, Georgios E Romanos
OBJECTIVE: The purpose of the present study was to review indexed literature and provide an update on the effectiveness of high-frequency radio waves (HRW) application in modern general dentistry procedures. DATA SOURCES: Indexed databases were searched to identify articles that assessed the efficacy of radio waves in dental procedures. RESULTS: Radiosurgery is a refined form of electrosurgery that uses waves of electrons at a radiofrequency ranging between 2 and 4 MHz...
April 28, 2017: Quintessence International
https://www.readbyqxmd.com/read/28454258/locally-advanced-paranasal-sinus-carcinoma-a-study-of-30-patients
#13
Francesco Perri, Raffaele Addeo, Manuel Conson, Adriana Faiella, Giuseppina Della Vittoria Scarpati, Gabriella Torre, Angela Di Biase, Paola Romanelli, Carlo Buonerba, Giuseppe Di Lorenzo, Antonio Daponte, Francesco Caponigro, Salvatore Pisconti, Roberto Pacelli, Vincenzo Ravo, Paolo Muto, Raffaele Solla
Sinonasal carcinomas (SNcs) are rare neoplasms arising from the paranasal sinuses and nasal cavity. Although these tumours have a heterogeneous histology, they are commonly diagnosed as a locally advanced disease and are associated with a poor prognosis. The present retrospective study reviewed 30 patients with locally advanced SNc, who were treated with surgery followed by chemoradiotherapy or radiotherapy, or radiotherapy with or without concomitant chemotherapy between January 1999 and January 2013 at the Department of Radiation Therapy, University of Naples 'Federico II' (Naples, Italy)...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28449480/reconstruction-of-mediastinal-vessels-for-invasive-thymoma-a-retrospective-analysis-of-25-cases
#14
Yifeng Sun, Chang Gu, Jianxin Shi, Wentao Fang, Qingquan Luo, Dingzhong Hu, Shijie Fu, Xufeng Pan, Yong Chen, Yu Yang, Haitang Yang, Heng Zhao, Haiquan Chen
BACKGROUND: Discuss an appropriate strategy for treatment of invasive thymoma invading adjacent great vessels. METHODS: A retrospective study on 25 patients with invasive thymoma invading neighboring great vessels was performed. The corresponding data including clinical presentation, operation procedure, adjuvant radio-chemotherapy and follow-up were reviewed. RESULTS: Twenty of 25 (80%) patients with invasive thymoma underwent complete resection of the tumor along with vessel reconstruction...
March 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28448708/-wrist-x-ray-for-analysis-of-the-articular-surface-of-distal-radius
#15
E Vergara-Amador, R Penagos, E Pinilla
In the distal radius fracture requires radiographic views that allow you to see the articular surface without interposition. The objective was to determine whether lateral radiographic projections 7 and 22° improve the analysis of this surface. METHOD: Case series study with radiographs of healthy and operated patients, in order to identify the lunate and scaphoid facets in lateral and anteroposterior projections. Qualitative analysis was made on the radiographs of the distal radius with wedges of 7 and 22° in the lateral views and 11° in the anteroposterior view...
September 2016: Acta Ortopédica Mexicana
https://www.readbyqxmd.com/read/28448252/hypothyroidism-in-carcinoma-of-the-tongue-with-adjuvant-treatment
#16
Sabita Kumari, Jonathan Gondi, Hemantkumar Nemade, L M Chandra Sekhara Rao, Deleep Gudipudi, T Subramanyeshwar Rao
OBJECTIVE: The objective of this study was to evaluate the incidence of hypothyroidism with adjuvant treatment in oral tongue carcinoma patients treated primarily with surgery. MATERIALS AND METHODS: A retrospective review was carried out to analyze hypothyroidism incidence and its relation to adjuvant treatment (radiation/radio-chemotherapy) in oral tongue carcinoma after the primary surgical ablation and neck dissection. Hypothyroidism was analyzed in relation with dose of radiation, gender, and adjuvant treatment modality...
March 29, 2017: Rambam Maimonides Medical Journal
https://www.readbyqxmd.com/read/28434963/recurrence-pattern-analysis-of-primary-glioblastoma
#17
Marion Rapp, Jessica Baernreuther, Bernd Turowski, Hans-Jakob Steiger, Michael Sabel, Marcel A Kamp
OBJECTIVE: The typical recurrence of a glioblastoma occurs locally, usually within 2 cm from the original lesion. With the improvement of surgery techniques, more aggressive surgical strategies have become feasible, resulting in a significantly increased rate of complete resection. Therefore, we were interested, if these improvements are also reflected by the tumor recurrence pattern. PATIENTS AND METHODS: Inclusion criteria were: first diagnosis of glioblastoma, followed by standard adjuvant radio-chemotherapy and histologically proven tumor recurrence...
April 18, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28416263/the-keys-to-conservative-treatment-of-early-stage-squamous-cell-carcinoma-of-the-tonsillar-region
#18
O Laccourreye, P Castelnau-Marchand, F Rubin, C Badoual, P Halimi, P Giraud
To analyze the medical literature devoted to work-up, epidemiology, local control, survival, complications and sequelae after conservative treatment for early-stage squamous cell carcinoma of the tonsillar region. An analysis of the PubMed (1975-2016) database was performed using the following keywords and associations: "tonsil/tonsillar region/oropharynx" AND "squamous cell carcinoma" AND "early-stage (I-II; T1-2N0M0)" AND "radiation therapy/radiotherapy" OR "conservative surgery/oropharyngectomy/transoral surgery/radical tonsillectomy"...
April 14, 2017: European Annals of Otorhinolaryngology, Head and Neck Diseases
https://www.readbyqxmd.com/read/28408882/targeted-nanotechnology-in-glioblastoma-multiforme
#19
REVIEW
Talita Glaser, Inbo Han, Liquan Wu, Xiang Zeng
Gliomas, and in particular glioblastoma multiforme, are aggressive brain tumors characterized by a poor prognosis and high rates of recurrence. Current treatment strategies are based on open surgery, chemotherapy (temozolomide) and radiotherapy. However, none of these treatments, alone or in combination, are considered effective in managing this devastating disease, resulting in a median survival time of less than 15 months. The efficiency of chemotherapy is mainly compromised by the blood-brain barrier (BBB) that selectively inhibits drugs from infiltrating into the tumor mass...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28394551/mesonephric-adenocarcinoma-of-endocervix-with-lobular-mesonephric-hyperplasia-case-report
#20
Mario Puljiz, Damir Danolić, Lucija Kostić, Ilija Alvir, Darko Tomica, Ivica Mamić, Ivana Vlastelica Munivrana, Marko Puljiz, Danko Velimir Vrdoljak, Melita Perić Balja
Mesonephric adenocarcinoma is a rare variant of cervical adenocarcinoma. We present a case of mesonephric adenocarcinoma of endocervix with cervical and vaginal lobular mesonephric hyperplasia in a 57-year-old woman. Vaginal bleeding persisting for 12 months was the only symptom. Histopathologic findings and characteristic immunophenotype are crucial for the diagnosis. The tumor was composed of papillary formation with a central fi brovascular stroma, villoglandular and densely compact tubular structures containing intraluminal eosinophilic secretion, and coated with one or more rows of cylindrical atypical epithelial cells...
June 2016: Acta Clinica Croatica
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