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https://www.readbyqxmd.com/read/29124955/current-issues-of-preoperative-radio-chemo-therapy-and-its-future-evolution-in-locally-advanced-rectal-cancer
#1
Bin Ma, Qingzhou Xu, Yongxi Song, Peng Gao, Zhenning Wang
Neoadjuvant therapies are effective for local control and tumor downstaging. Up to date, preoperative long-course chemoradiotherapy and short-course radiotherapy are the two primary guideline-recommended neoadjuvant therapies for locally advanced rectal cancer patients. However, clinicians throughout the world are trying their best to further optimize the regimens and concepts of neoadjuvants. Hence, there is an urgent need to summarize evidence regarding indications of neaoadjuvant therapies and relative merits of current standard regimens...
November 10, 2017: Future Oncology
https://www.readbyqxmd.com/read/29122306/carmustine-wafer-implantation-for-high-grade-gliomas-evidence-based-safety-efficacy-and-practical-recommendations-from-the-neuro-oncology-club-of-the-french-society-of-neurosurgery
#2
REVIEW
A Roux, F Caire, J Guyotat, P Menei, P Metellus, J Pallud
There is a growing body of evidence that carmustine wafer implantation during surgery is an effective therapeutic adjunct to the standard combined radio-chemotherapy regimen using temozolomide in newly diagnosed and recurrent high-grade glioma patient management with a statistically significant survival benefit demonstrated across several randomized clinical trials, as well as prospective and retrospective studies (grade A recommendation). Compelling clinical data also support the safety of carmustine wafer implantation (grade A recommendation) in these patients and suggest that observed adverse events can be avoided in experienced neurosurgeon hands...
November 6, 2017: Neuro-Chirurgie
https://www.readbyqxmd.com/read/29114890/total-septal-perforation-repair-with-a-pericranial-flap-radio-anatomical-and-clinical-findings
#3
Isam Alobid, Cristóbal Langdon, Mauricio López-Chacon, Joaquim Enseñat, Ricardo Carrau, Manuel Bernal-Sprekelsen, Alfonso Santamaría
OBJECTIVES/HYPOTHESIS: Endonasal surgeries are the primary cause of septal perforation (SP). However, trauma, inflammation, infections, neoplasms, or abuse of inhaled drugs can also cause SP. Septal repair is indicated in patients who experience nasal obstruction, crusting, intermittent epistaxis, purulent discharge, or nasal whistling and in those who fail conservative treatment. Multiple approaches have been suggested to repair the SP; however, none has been universally adopted. This study explores the feasibility of repairing a total SP using the pericranial flap (PCF)...
November 8, 2017: Laryngoscope
https://www.readbyqxmd.com/read/29110129/real-life-management-and-outcome-of-thyroid-carcinoma-related-bone-metastases-results-from-a-nationwide-multicenter-experience
#4
G Mazziotti, A M Formenti, M B Panarotto, E Arvat, A Chiti, A Cuocolo, M E Dottorini, C Durante, L Agate, S Filetti, F Felicetti, A Filice, L Pace, T Pellegrino, M Rodari, M Salvatori, C Tranfaglia, A Versari, D Viola, S Frara, A Berruti, A Giustina, R Giubbini
PURPOSE AND PATIENTS: The M.O.S.CA.TI. (Metastases of the Skeleton from CArcinoma of the ThyroId) is a multicenter, retrospective study investigating the real-life outcome and management of bone metastases (BM) in 143 patients (63 M, 80 F; median age 64 years, range 11-87) with differentiated thyroid carcinoma (DTC). RESULTS: Radio-active iodine (RAI) treatment was performed in 131 patients (91.6%), surgical approach and/or external radiotherapy in 68 patients (47...
November 6, 2017: Endocrine
https://www.readbyqxmd.com/read/29109052/magnetic-resonance-imaging-with-rf-encoding-on-curved-natural-slices
#5
Gordon E Sarty, Logi Vidarsson
While the idea of using spatial encoding fields (SEM) for image formation has been proven, conventional wisdom still holds that a magnetic resonance imaging (MRI) system begins with a highly uniform magnetic field. In particular, radio frequency (RF) encoding MRIs designed and tested to date have largely used uniform magnetic fields. Here we demonstrate magnetic resonance imaging in a magnetic field with a built-in gradient that gives non-planar slices - curved surfaces - when the nuclear spins are excited with narrow band RF pulses...
November 4, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/29081846/avascular-necrosis-in-children-with-cerebral-palsy-after-reconstructive-hip-surgery
#6
L Phillips, K Hesketh, E K Schaeffer, J Andrade, J Farr, K Mulpuri
PURPOSE: Progressive hip displacement is one of the most common orthopaedic pathologies in children with cerebral palsy (CP). Reconstructive hip surgery has become the standard treatment of care. Reported avascular necrosis (AVN) rates for hip reconstructive surgery in these patients vary widely in the literature. The purpose of this study is to identify the frequency and associated risk factors of AVN for reconstructive hip procedures. METHODS: A retrospective analysis was performed of 70 cases of reconstructive hip surgery in 47 children with CP, between 2009 and 2013...
October 1, 2017: Journal of Children's Orthopaedics
https://www.readbyqxmd.com/read/29081843/clinical-staging-of-nsclc-current-evidence-and-implications-for-adjuvant-chemotherapy
#7
REVIEW
David J Heineman, Johannes M Daniels, Wilhelmina H Schreurs
Survival of all non-small cell lung cancer (NSCLC) patients is disappointing, with a 5-year survival of 18%. Staging NSCLC patients is crucial because it determines the choice of treatment and prognosis. Clinical staging is a complex process that comes with many challenges and with low accuracy between the clinical and pathological stage. Treatment modalities for stage I-III NSCLC consist of surgical resection, radiotherapy and chemotherapy. This review describes the current evidence on staging and the implications on adjuvant chemotherapy...
September 2017: Therapeutic Advances in Medical Oncology
https://www.readbyqxmd.com/read/29061455/epidermal-growth-factor-receptor-expression-predicts-time-and-patterns-of-recurrence-in-glioblastoma-patients-following-radiotherapy-and-temozolomide
#8
Paolo Tini, Valerio Nardone, Pierpaolo Pastina, Giuseppe Battaglia, Clelia Miracco, Salvatore Francesco Carbone, Lucio Sebaste, Giovanni Rubino, Alfonso Cerase, Luigi Pirtoli
BACKGROUND: and Purpose: The aim is to investigate the potential role of EGFR protein expression in predicting the modality of treatment failure in Glioblastoma (GB). MATERIAL AND METHOD: Patients with unifocal GB undergoing surgery and postoperative radio-chemotherapy (RT-TMZ) from February 2008 to July 2015 were included into the study. The EGFR protein expression level was assessed by immunohistochemistry in GB tissues and classified into High (H-EGFR) and Low (L-EGFR) expression...
October 20, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29026276/five-cases-of-childhood-onset-graves-disease-treated-with-either-surgery-or-radio-iodine-therapy
#9
Kouki Tomari, Masahiro Goto, Aya Shimada, Hiroko Yagi, Yuka Nagashima, Yukihiro Hasegawa
There are three major therapeutic options for the treatment of Graves' disease (GD): antithyroid drugs (ATDs), thyroidectomy, and radio-iodine (RAI) therapy. ATDs are the initial treatment option for children. However, some pediatric GD patients who are initially treated with ATDs require other type of treatments later on. We reviewed the medical records of childhood-onset GD cases retrospectively to report the clinical course of patients who received either surgery or RAI therapy subsequent to treatment with ATDs...
2017: Clinical Pediatric Endocrinology: Case Reports and Clinical Investigations: Official Journal of the Japanese Society for Pediatric Endocrinology
https://www.readbyqxmd.com/read/29021982/autologous-periosteum-derived-micrografts-and-plga-ha-enhance-the-bone-formation-in-sinus-lift-augmentation
#10
Ruggero Rodriguez Y Baena, Riccardo D'Aquino, Antonio Graziano, Letizia Trovato, Antonio C Aloise, Gabriele Ceccarelli, Gabriella Cusella, André A Pelegrine, Saturnino M Lupi
Sinus lift augmentation is a procedure required for the placement of a dental implant, whose success can be limited by the quantity or quality of available bone. To this purpose, the first aim of the current study was to evaluate the ability of autologous periosteum-derived micrografts and Poly(lactic-co-glycolic acid) (PLGA) supplemented with hydroxyl apatite (HA) to induce bone augmentation in the sinus lift procedure. Secondly, we compared the micrograft's behavior with respect to biomaterial alone, including Bio-Oss® and PLGA/HA, commercially named Alos...
2017: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/29017600/ions-doped-melanin-nanoparticle-as-a-multiple-imaging-agent
#11
Shin-Woo Ha, Hee-Sang Cho, Young Il Yoon, Moon-Sun Jang, Kwan Soo Hong, Emmanuel Hui, Jung Hee Lee, Tae-Jong Yoon
BACKGROUND: Multimodal nanomaterials are useful for providing enhanced diagnostic information simultaneously for a variety of in vivo imaging methods. According to our research findings, these multimodal nanomaterials offer promising applications for cancer therapy. RESULTS: Melanin nanoparticles can be used as a platform imaging material and they can be simply produced by complexation with various imaging active ions. They are capable of specifically targeting epidermal growth factor receptor (EGFR)-expressing cancer cells by being anchored with a specific antibody...
October 10, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/29016555/interleukin-10-regulated-tumour-tolerance-in-non-small-cell-lung-cancer
#12
Julius Malte Vahl, Juliane Friedrich, Susanne Mittler, Sonja Trump, Lisanne Heim, Katerina Kachler, Liubov Balabko, Nicole Fuhrich, Carol-Immanuel Geppert, Denis Iulian Trufa, Nina Sopel, Ralf Rieker, Horia Sirbu, Susetta Finotto
BACKGROUND: Lung cancer is the most life-threatening cancer type worldwide. Treatment options include surgery, radio- and chemotherapy, as well as the use of immunomodulatory antibodies. Interleukin (IL)-10 is an immunosuppressive cytokine involved in tumour immune escape. METHODS: Immunohistochemistry (IHC) on human lung surgery tissue as well as human tumour cell line cultures, FACS analysis, real-time PCR and experimental lung cancer. RESULTS: Here we discovered a positive correlation between IL-10 and IL-10 receptor (IL-10R) expression in the lung with tumour diameter in patients with lung cancer (non-small cell lung cancer), the most life-threatening cancer type worldwide...
October 10, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28972890/stereotactic-radio-surgery-and-radio-frequency-rhizotomy-for-trigeminal-neuralgia-in-multiple-sclerosis-a-single-institution-experience
#13
Marshall T Holland, Nahom Teferi, Jennifer Noeller, Andrea Swenson, Mark Smith, John Buatti, Patrick W Hitchon
OBJECTIVES: For patients with medically unresponsive trigeminal neuralgia (TN), surgical options include micro vascular decompression (MVD), radiofrequency rhizotomy (RF), and stereotactic radio surgery (SRS). Multiple sclerosis (MS) is a demyelinating condition that can be associated with TN, but is not amenable to treatment with MVD. We sought to identify the outcome differences of patients with TN in MS undergoing SRS or RFR in an attempt to identify factors that may influence outcomes...
November 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28969224/neglected-type-i-monteggia-fracture-dislocation-in-adult
#14
Archit Agarwal, Inder Pawar
Neglected Monteggia fracture dislocation is one of the challenging case and it becomes more of a therapeutic dilemma especially in adults. Several surgical techniques are described and in spite of this complication rate following surgery is high. This report concerns with management of three-month-old monteggia fracture dislocation in a 30-year-old male. Patient presented with complete loss of movement at elbow. Patient was managed surgically, with internal fixation of ulna and reduction of radial head with radio-capitellar Kirschner wires...
August 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28929063/lymph-node-central-necrosis-on-the-computed-tomography-as-the-predictor-of-the-extra-capsular-spread-in-metastatic-head-and-neck-squamous-cell-carcinoma
#15
Aditi Sharma, Ashwin Ashok Jaiswal, Girish Umredkar, Ratiram Barle, Neeta Sharma, Praveer Kumar Banerjee, Amrish Kumar Garg, Ravindranath Membally
The aim of this study is to investigate the relationship between the presence of the cervical lymph node with central necrosis as on the preoperative imaging and postoperative histopathological identification of the lymph node extra capsular spread. This study is a prospective study conducted at J.L.N. Hospital and Research Centre, Bhilai (C.G), from August 2011 to January 2014. Thirty patients with metastatic head and neck squamous cell carcinoma were enrolled. All candidates were subjected to a detailed history taking and clinical examination...
September 2017: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/28905080/-treatment-of-retroperitoneal-sarcoma-in-germany-results-of-a%C3%A2-survey-of-the-german-society-of-general-and-visceral-surgery-the-german-interdisciplinary-sarcoma-study-group-and-the-advocacy-group-das-lebenshaus
#16
J Jakob, A Gerres, U Ronellenfitsch, L Pilz, M Wartenberg, B Kasper, H-R Raab, P Hohenberger
OBJECTIVE: Retroperitoneal sarcomas (RPSs) are rare cancers with some variability in clinical and histopathological presentation. In Germany, general treatment strategies of retroperitoneal sarcoma are unknown since centralized registries do not exist. The objective of this survey was to access the medical care of RPS patients in Germany. METHODS: In cooperation with the German Society of General and Visceral surgery, the German Interdisciplinary Sarcoma Study Group and the patient advocacy group Das Lebenshaus we designed an online survey assessing diagnostic and treatment strategies (e...
September 13, 2017: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/28888800/percutaneous-lung-ablation-of-pulmonary-recurrence-may-improve-survival-in-selected-patients-undergoing-cytoreductive-surgery-for-colorectal-cancer-with-peritoneal-carcinomatosis
#17
T A Bin Traiki, O M Fisher, S J Valle, R N Parikh, M A Kozman, D Glenn, M Power, W Liauw, N A Alzahrani, D L Morris
PURPOSE: To analyze the outcomes of patients developing pulmonary metastases (PM) following cytoreductive surgery (CRS) and perioperative intra-peritoneal chemotherapy (IPC) for colorectal cancer (CRC) with peritoneal carcinomatosis. PATIENTS AND METHODS: A retrospective analysis of patients undergoing CRS/IPC for CRC from 1996 to 2016 was performed. Lung-specific disease-free and patient overall survival was analyzed. Patients undergoing percutaneous lung ablative therapy (PLAT) for PM were compared to patients receiving systemic chemotherapy alone...
October 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28886982/management-of-epilepsy-due-to-hypothalamic-hamartomas
#18
REVIEW
Ayaz M Khawaja, Sandipan Pati, Yu-Tze Ng
A hypothalamic hamartoma consists of hyperplastic heterotopic tissue growing in a disorganized fashion. These lesions occur in about one per 50,000 to 100,000 people. Hypothalamic hamartomas can cause intrinsic epileptogenesis leading to gelastic seizures. Surrounding cortical structures may also develop secondary epileptogenesis. Persistent seizures caused by hypothalamic hamartomas can be debilitating and result in significant cognitive and behavioral impairment. Early recognition and treatment is important in controlling seizures and in preventing further cognitive deterioration...
July 5, 2017: Pediatric Neurology
https://www.readbyqxmd.com/read/28876551/breast-ductal-carcinoma-in-situ-in-an-unscreened-population-presentation-diagnosis-and-management-at-a-single-tertiary-centre
#19
M Mutebi, H Simonds
BACKGROUND: To determine the clinical presentation of patients presenting with isolated ductal carcinoma in situ at a single tertiary center in the Cape Town, South Africa. To review the diagnostic techniques most commonly used and the primary surgery performed for these patients. METHOD: We performed a retrospective folder review of patients diagnosed with DCIS over a period from Jan 2005 to Dec 2012, at the Combined Breast Cancer Clinic at Groote Schuur Hospital...
March 2017: South African Journal of Surgery. Suid-Afrikaanse Tydskrif Vir Chirurgie
https://www.readbyqxmd.com/read/28873063/a-descriptive-cross-sectional-study-to-assess-quality-of-life-and-sexuality-in-turkish-patients-with-a-colostomy
#20
Emel Yilmaz, Dilruba Çelebi, Yavuz Kaya, Hakan Baydur
A stoma affects personality, self-esteem, and body image, inevitably impacting lifestyle and quality of life (QOL). A descriptive, cross-sectional study was conducted between May 1, 2015 and May 1, 2016 to evaluate the effect of a stoma on sexual function and QOL among patients receiving care in a general surgery clinic of a university hospital in the western region of Turkey.Eligibility requirements included patients willing to participate, >18 years of age, with a colostomy for at least 4 months, who were married and/or with a sexual partner and in otherwise good physical and mental health with no rectal nerve damage or receiving radio- or chemotherapy...
August 2017: Ostomy/wound Management
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