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https://www.readbyqxmd.com/read/28633125/primary-squamous-cell-carcinoma-of-the-thyroid-case-report-and-systematic-review-of-the-literature
#1
Florian Struller, Moritz Senne, Claudius Falch, Andreas Kirschniak, Alfred Konigsrainer, Sven Muller
BACKGROUND: Primary squamous cell cancer (PSCC) of thyroid is a rare malignancy with poor prognosis. It is mandatory to exclude secondary involvement of the thyroid by panendoscopy, CT-scan and immunohistochemical analysis. As treatment surgery, radiation and rarely chemotherapy is employed. METHODS: A systematic review of the literature was conducted searching medline and embase database using the medical subject headings "primary squamous cell carcinoma of thyroid" and "primary squamous cell cancer of thyroid", for articles published until April 2016 (n=1733)...
June 13, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28621575/analysis-of-radio-sensitization-patents-in-china-from-2006-to-2015
#2
Guofeng He, Xiaoke Di, Xinchen Sun, Jingjing Yan, Shu Zhang
Radiotherapy is by means of ionizing radiation to kill tumor cells, inhibit and control the growth, metastasis and diffusion of tumor cells. During the last few decades, application of radiotherapy combined with chemotherapy and surgery are clinical mainstream treatments. However, little is known what radio-sensitization agents have been patented in China and what the potential drug candidates for patents are in China. Areas covered: This reviews covers research and patent literature of the last 10 years dealing with the discovery and development of novel radio-sensitization patents in China
...
June 16, 2017: Expert Opinion on Therapeutic Patents
https://www.readbyqxmd.com/read/28621181/-advantages-of-transanal-approach-in-low-rectal-cancer-resections
#3
Géza Papp, István Besznyák, Balázs Pörneczi, György Saftics, Attila Bursics
Laparoscopic surgery is proven equal technique to open rectal surgery. Despite advantages, some problems in case of low rectal surgery are existing: visualization of the pelvis, securing safe distal resection margin, preparing single stapled rectal stump with safe conjunction to the colorectal anastomosis. Approximately 500 procedures have been performed worldwide until today by applying Transanal Total Mesorectal Excision (TaTME) technique, which evolved from a combination of laparoscopy and transanal approach...
June 2017: Magyar Sebészet
https://www.readbyqxmd.com/read/28610905/anal-cancer-french-intergroup-clinical-practice-guidelines-for-diagnosis-treatment-and-follow-up
#4
REVIEW
Laurence Moureau-Zabotto, Veronique Vendrely, Laurent Abramowitz, Christophe Borg, Eric Francois, Diane Goere, Florence Huguet, Didier Peiffert, Laurent Siproudhis, Michel Ducreux, Olivier Bouché
INTRODUCTION: This document is a summary of the French Intergroup guidelines regarding the management of anal carcinomas, published in November 2016. METHODS: It is a collaborative work produced under the auspices of the majority of the French medical societies involved in the management of anal cancer. It is based on the previous guidelines published in 2010. Recommendations are graded in three categories, according to the amount of evidence found in the literature...
May 23, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28602545/what-is-the-impact-of-neoadjuvant-chemoradiation-on-outcomes-in-gastro-intestinal-cancer
#5
C Mariette, A Brouquet, D Tzanis, A Laurenzi, A de la Rochefordière, P Mariani, G Piessen, A Sa Cunha, C Penna
Multimodal therapeutic strategies combining chemotherapy, radiation therapy and surgery have been shown to be feasible and to have a positive impact on outcomes by decreasing the risk of locoregional recurrence and often by increasing overall survival. The advantages of neoadjuvant chemo(radio)therapy include optimal tumor control combined with better tolerance and compliance to treatment while also increasing the number of candidates for surgery. Whereas indications for neoadjuvant therapy are increasing, its impact on surgical treatment and postoperative outcomes are not well-known...
June 8, 2017: Journal of Visceral Surgery
https://www.readbyqxmd.com/read/28588793/double-blind-randomized-study-of-oral-glutamine-on-the-management-of-radio-chemotherapy-induced-mucositis-and-dermatitis-in-head-and-neck-cancer
#6
David Lopez-Vaquero, Lucia Gutierrez-Bayard, Juan-Andres Rodriguez-Ruiz, Monica Saldaña-Valderas, Pedro Infante-Cossio
This randomized clinical trial was designed to determine whether glutamine administration was effective in reducing the incidence and severity of mucositis and dermatitis induced by radiotherapy (RT) or chemoradiotherapy (CHRT) in patients with head and neck cancer (HNC). Fifty patients were randomized to receive orally either L-Glutamine or placebo (25 patients in each arm). In the glutamine-treated group, 10 g of oral glutamine was administered three times daily. The primary endpoint was to compare the appearance of clinical mucositis between groups at the 6th week, according to the Common Terminology Criteria for Adverse Events...
June 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28583790/transanal-endoscopic-microsurgery-after-neoadjuvant-radiochemotherapy-for-locally-advanced-extraperitoneal-rectal-cancer
#7
G Rizzo, G Zaccone, M Magnocavallo, C Mattana, D P Pafundi, M A Gambacorta, V Valentini, C Coco
PURPOSE: The aim of this study is to provide a prospective analysis of post-operative and oncological outcomes in patients affected by locally advanced rectal cancer (LARC), who obtained a major/complete clinical response after pre-operative radio-chemotherapy (RCT) and were treated with local excision (LE) by trans-anal endoscopic microsurgery (TEM) to confirm a pathological complete response (pCR) after to neo-adjuvant RCT. METHODS: All patients with LARC treated by pre-operative RCT and full-thickness LE by TEM (2000-2014) were included in the study...
May 25, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28579341/percutaneous-ultrasound-guided-fiducial-marker-placement-for-liver-cancer-robotic-stereotactic-radio-surgery-treatment-a-comparative-analysis-of-three-types-of-markers-and-needles
#8
Maria Marsico, Tommaso Gabbani, Sarah Lunardi, Andrea Galli, Maria Rosa Biagini, Vito Annese
BACKGROUND AND STUDY AIMS: Percutaneous placement of fiducial markers is required to perform stereotactic body radiation therapy (SBRT) for liver neoplastic lesions. This prospective trial was designed to evaluate the feasibility and safety of percutaneous ultrasound-guided placement of three different types of markers in patients with liver cancer referred for SBRT. PATIENTS AND METHODS: Fifty patients underwent percutaneous ultrasound-guided implantation of a fiducial marker in the liver...
June 1, 2017: Arab Journal of Gastroenterology: the Official Publication of the Pan-Arab Association of Gastroenterology
https://www.readbyqxmd.com/read/28566437/local-dna-repair-inhibition-for-sustained-radiosensitization-in-high-grade-gliomas
#9
Amanda R King, Christopher D Corso, Evan M Chen, Eric Song, Paul Bongiorni, Zhe Chen, Ranjini K Sundaram, Ranjit S Bindra, W Mark Saltzman
High-grade gliomas such as glioblastoma (GBM) and diffuse intrinsic pontine glioma (DIPG) are characterized by an aggressive phenotype with nearly universal local disease progression despite multimodal treatment, which typically includes chemotherapy, radiation therapy (RT), and possibly surgery. Radiosensitizers that have improved the effects of RT for extracranial tumors have been ineffective for the treatment of GBM and DIPG, in part due to poor blood brain barrier penetration and rapid intracranial clearance of small molecules...
May 31, 2017: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/28566172/pattern-of-care-and-outcome-in-elderly-patients-with-glioblastoma-data-in-151-patients-from-3-lombardia-hospitals
#10
Andrea Rigamonti, Francesca Imbesi, Antonio Silvani, Gianluca Grimod, Valentina Prone, Paola Gaviani, Antonio Ardizzoia, Ida Milanesi, Virginia Arienti, Elio Agostoni, Francesco Di Meco, Andrea Salmaggi
The appropriate treatment approach for elderly patients with glioblastoma multiforme (GBM) is unclear, although different studies suggest survival benefit in fit patients treated with radiotherapy and chemiotherapy after surgery. We performed a retrospective analysis of 151 patients older than 65years with GBM treated in 3 Lombardia Hospitals. In univariate regression analysis higher KPS (p=0.02), macroscopical total resection (p<0.003), radiotherapy (p<0.0001), chemotherapy (p<0.0001) and second line chemotheraphy (p=0...
July 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28560660/impact-of-treatment-on-survival-of-patients-with-secondary-glioblastoma
#11
Christina Hamisch, Maximilian Ruge, Stephanie Kellermann, Ann-Cathrin Kohl, Inga Duval, Roland Goldbrunner, Stefan J Grau
Data concerning treatment of secondary glioblastoma evolving from previously treated WHO II or III grade tumors are very scarce. The aim of this study was to evaluate the impact of surgical resection and adjuvant treatment on survival in patients with secondary glioblastoma. Thirty-nine patients with secondary glioblastoma evolving from previously treated lower grade gliomas between 2004 and 2015 were included. We evaluated the extent of resection, pathological parameters, adjuvant treatment, as well as survival after malignant transformation...
May 30, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28555274/survival-analysis-of-287-oropharyngeal-squamous-cell-carcinoma-patients-in-a-single-institution-a-retrospective-comparison-of-two-consecutive-time-intervals-with-surgical-and-conservative-treatment-approaches
#12
Adrian Münscher, Lara Bussmann, Susanne Sehner, Simon Knaack, Alexandra Gliese, Silke Tribius, Till Clauditz, Balazs B Lörincz
This study is a retrospective analysis of clinico-pathological data to investigate survival rates of patients with oropharyngeal squamous cell carcinoma (OPSCC) treated with different modalities in a single academic head and neck cancer center in different time intervals. Altogether, 287 patients with OPSCC were included in this comparison. Patients were analysed during two different treatment periods: Group 1 included patients treated mainly with primary surgery ± adjuvant radio(chemo)therapy between 2002 and 2007, while Group 2 included patients treated with organ/function-preservation protocols if indicated...
May 29, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28537901/inflammatory-cytokines-are-associated-with-response-and-prognosis-in-patients-with-esophageal-cancer
#13
Susanne Blank, Henrik Nienhüser, Lena Dreikhausen, Leila Sisic, Ulrike Heger, Katja Ott, Thomas Schmidt
BACKGROUND: Esophageal cancer is often marked by aggressive tumor growth and poor prognosis. Patient groups who benefit from perioperative therapy are not yet defined. The tumor microenvironment and circulating factors as possible predictors of response and prognosis gain interest. This study aimed to investigate cytokines in patients' serum and tumor tissue with regard to response and prognosis. RESULTS: Median survival between SCC and AC was not different (published previously)...
May 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/28512411/spinal-intradural-intramedullary-dissemination-in-the-absence-of-intracranial-relapse-of-a-previously-radically-treated-temporal-lobe-glioblastoma-multiforme
#14
Lucas Serrano, Eleftherios Archavlis, Elke Januschek, Pavel Timofeev, Peter Ulrich
Intracranial glioblastoma multiforme (GBM) constitutes the most frequent and unfortunately aggressive primary central nervous system malignancy. Despite the high tendency of these tumors to show local relapse within the brain after primary therapy, dissemination into the spinal axis is an infrequent event. If spinal metastases occur they are leptomeningeal in the vast majority of cases and always in the context of intracranial progressive disease. Spinal intramedullary metastases of intracranial GBM have rarely been described to date...
January 2017: Case Reports in Oncology
https://www.readbyqxmd.com/read/28506419/radioguided-thyroidectomy-for-follicular-tumors-multicentric-experience
#15
D Parmeggiani, C Gambardella, R Patrone, A Polistena, M De Falco, R Ruggiero, R Cirocchi, A Sanguinetti, V Cuccurullo, M Accardo, N Avenia, G Docimo, S Tolone, V Bassi, L Docimo, G Conzo
BACKGROUND: The diagnosis of thyroid nodular diseases requires an integrated approach that has been widely established over the past years. This strategy includes: ultrasonography (US) with; implemented Color-Power-Doppler, conventional scintigraphy also with positive indicators, specific pathological studies targeted by immunohistochemically-assays, and the fine needle; aspiration biopsy (FNAB), which, usually, in case of "Follicular Lesions" (10-20%) findings is; unable to distinguish carcinoma from follicular adenoma, then indicating the necessity of surgery to; obtain a correct diagnosis...
May 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28500597/blood-pressure-monitoring-using-radio-telemetry-method-in-mice
#16
Yu Wang, Sean E Thatcher, Lisa A Cassis
The TA11PA-C10 implantable transmitter (Data Sciences International, DSI) is designed to measure blood pressure (BP) and activity in freely moving laboratory mice. The fluid filled catheter is placed in the free flowing blood of the systemic artery (inserted into the left carotid artery and extended into the aorta), and the transmitter body is placed in a benign location for long-term biocompatibility. The transmitter can be used to monitor BP in mice (as small as 17 g) under normal physiological and unrestricted conditions 24 h a day while remaining free from stress associated with human interaction...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28499389/a-phase-ii-trial-of-autologous-dendritic-cell-vaccination-and-radiochemotherapy-following-fluorescence-guided-surgery-in-newly-diagnosed-glioblastoma-patients
#17
Susana Inogés, Sonia Tejada, Ascensión López-Díaz de Cerio, Jaime Gállego Pérez-Larraya, Jaime Espinós, Miguel Angel Idoate, Pablo Daniel Domínguez, Reyes García de Eulate, Javier Aristu, Maurizio Bendandi, Fernando Pastor, Marta Alonso, Enrique Andreu, Felipe Prósper Cardoso, Ricardo Díez Valle
BACKGROUND: Prognosis of patients with glioblastoma multiforme (GBM) remains dismal, with median overall survival (OS) of about 15 months. It is therefore crucial to search alternative strategies that improve these results obtained with conventional treatments. In this context, immunotherapy seems to be a promising therapeutic option. We hypothesized that the addition of tumor lysate-pulsed autologous dendritic cells (DCs) vaccination to maximal safe resection followed by radiotherapy and concomitant and adjuvant temozolomide could improve patients' survival...
May 12, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/28498880/a-two-arm-multicenter-phase-ii-trial-of-one-cycle-chemoselection-split-dose-docetaxel-cisplatin-and-5-fluorouracil-tpf-induction-chemotherapy-before-two-cycles-of-split-tpf-followed-by-curative-surgery-combined-with-postoperative-radiotherapy-in-patients-with
#18
J Inhestern, H Schmalenberg, A Dietz, N Rotter, G Maschmeyer, M Jungehülsing, C Grosse-Thie, T Kuhnt, M Görner, H Sudhoff, C Wittekindt, O Guntinas-Lichius
Background: : Induction chemotherapy (ICT) with docetaxel, cisplatin and fluorouracil (TPF) followed by radiotherapy is an effective treatment option for locally advanced head and neck cancer. This phase II study investigated the effectivity of a split-dose TPF ICT prior to surgery for locally advanced resectable (stage III/IVA) oral and oropharyngeal cancer. Patients and methods: : Patients received TPF split on two dosages on day 1 and 8 per cycle (30 mg/m 2 docetaxel, 40 mg/m 2 cisplatin, 2000 mg/m 2 fluorouracil per week)...
May 11, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28497194/treatment-and-outcomes-of-recurrent-hepatocellular-carcinomas
#19
Gaëtan-Romain Joliat, Pierre Allemann, Ismail Labgaa, Nicolas Demartines, Nermin Halkic
PURPOSE: Surgery is one of the best options for curative treatment of hepatocellular carcinomas (HCC). Recurrences are nevertheless common (45-75%). This study aimed to compare overall survival (OS) of patients with recurrent HCC after primary resection to OS of patients without recurrence. METHODS: A retrospective review of all HCC patients operated between 1993 and 2015 was performed. Median and 5-year OS were calculated. RESULTS: This study included 147 HCC patients...
May 11, 2017: Langenbeck's Archives of Surgery
https://www.readbyqxmd.com/read/28478739/translocation-renal-cell-carcinoma-in-a-child-previously-treated-for-infantile-fibrosarcoma
#20
Jing Ma, Ci Pan, Minzhi Yin
We report a child who developed a TFE3/Xp11.2 translocation renal cell carcinoma (RCC) when he was 3 years and 3 months old, after previous treatment for infantile fibrosarcoma (IFS). When he was 3 months old, a left axilla mass has been detected, which was tan and solid, was 1.5 cm in greatest dimension, and composed of sheets of spindle cells that was positive for vimentin and fibronectin. Fluorescence in situ hybridization showed positive result in ETV6 gene rearrangements. The final diagnosis was IFS...
January 1, 2017: Pediatric and Developmental Pathology
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