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Chronic adrenal stress

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https://www.readbyqxmd.com/read/28328011/when-emotional-pain-becomes-physical-adverse-childhood-experiences-pain-and-the-role-of-mood-and-anxiety-disorders
#1
Natalie J Sachs-Ericsson, Julia L Sheffler, Ian H Stanley, Jennifer R Piazza, Kristopher J Preacher
OBJECTIVE: We examined the association between retrospective reports of adverse childhood experiences (ACEs) and painful medical conditions. We also examined the mediating and moderating roles of mood and anxiety disorders in the ACEs-painful medical conditions relationship. METHOD: Ten-year longitudinal data were obtained from the National Comorbidity Surveys (NCS-1, NCS-2; N = 5001). The NCS-1 obtained reports of ACEs, current health conditions, current pain severity, and mood and anxiety disorders...
March 22, 2017: Journal of Clinical Psychology
https://www.readbyqxmd.com/read/28321600/post-6-ohda-lesion-exposure-to-stress-affects-neurotrophic-factor-expression-and-aggravates-motor-impairment
#2
Phumzile Nomfundo Ngema, Musa Vuyisile Mabandla
Chronic exposure to stress amplifies locomotor deficits and exacerbates dopamine neuron loss in an animal model for Parkinson's disease. The release of neurotrophic factors such as glial cell-line derived neurotrophic factor (GDNF) and neurotrophin-3 (NT-3) following neuronal injury attenuates exacerbated degeneration of these neurons. In this study, the neurotoxin 6-hydroxydopamine (6-OHDA) was injected unilaterally into the medial forebrain bundle of male Sprague Dawley rats. A subset of these rats was subjected to post-lesion restraint stress after which the effect of exposure to stress on locomotor activity (forelimb akinesia test), neurotrophic factor (GDNF and NT-3) and corticosterone concentration was assessed...
March 20, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/28320277/mechanisms-of-brain-glucocorticoid-resistance-in-stress-induced-psychopathologies
#3
REVIEW
V M Merkulov, T I Merkulova, N P Bondar
Exposure to stress activates the hypothalamic-pituitary-adrenal axis and leads to increased levels of glucocorticoid (GC) hormones. Prolonged elevation of GC levels causes neuronal dysfunction, decreases the density of synapses, and impairs neuronal plasticity. Decreased sensitivity to glucocorticoids (glucocorticoid resistance) that develops as a result of chronic stress is one of the characteristic features of stress-induced psychopathologies. In this article, we reviewed the published data on proposed molecular mechanisms that contribute to the development of glucocorticoid resistance in brain, including changes in the expression of the glucocorticoid receptor (GR) gene, biosynthesis of GR isoforms, and GR posttranslational modifications...
March 2017: Biochemistry. Biokhimii︠a︡
https://www.readbyqxmd.com/read/28315609/the-levonorgestrel-releasing-intrauterine-device-potentiates-stress-reactivity
#4
Jurate Aleknaviciute, Joke H M Tulen, Yolanda B De Rijke, Christian G Bouwkamp, Mark van der Kroeg, Mirjam Timmermans, Vincent L Wester, Veerle Bergink, Witte J G Hoogendijk, Henning Tiemeier, Elisabeth F C van Rossum, Cornelis G Kooiman, Steven A Kushner
BACKGROUND: The levonorgestrel-releasing intrauterine device (LNG-IUD) is currently recommended as a first-line contraceptive with an exclusively local intrauterine influence. However, recent clinical trials have identified side effects of LNG-IUD that appear to be systemically mediated, including depressed mood and emotional lability. METHODS: We performed two experimental studies and a cross-sectional study. For each study, women were included from three groups: LNG-IUD (0...
February 28, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28284169/salivary-diurnal-cortisol-profiles-in-patients-suffering-from-chronic-breathlessness-receiving-supportive-and-palliative-care-services-a-cross-sectional-study
#5
Richella Ryan, Angela Clow, Anna Spathis, Nina Smyth, Stephen Barclay, Marie Fallon, Sara Booth
Chronic breathlessness is a common source of psychological and physical stress in patients with advanced or progressive disease, suggesting that hypothalamic-pituitary-adrenal (HPA) axis dysregulation may be prevalent. The aim of this study was to measure the salivary diurnal cortisol profile in patients receiving supportive and palliative care for a range of malignant and non-malignant conditions and to compare the profile of those experiencing moderate-to-severe disability due to breathlessness against that of patients with mild/no breathlessness and that of healthy controls...
January 27, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28276947/assessment-of-depression-anxiety-quality-of-life-and-coping-in-long-standing-multiple-endocrine-neoplasia-type-2-patients
#6
Karine Candido Rodrigues, Rodrigo Almeida Toledo, Flavia Lima Coutinho, Adriana Bezerra Nunes, Rui M B Maciel, Ana Oliveira Hoff, Marcos C Tavares, Sergio P A Toledo, Delmar Muniz Lourenço
BACKGROUND: Scarce data on psychological harm in multiple endocrine neoplasia type 2 (MEN2) are available. OBJECTIVES: To assess anxiety, depression, quality of life and coping in long-standing MEN2 patients. PATIENTS AND METHODS: Forty-three adults (age ≥ 18 y) with clinical and genetic diagnosis of MEN2 and long-term follow-up (10.6±8.2 years; 1-33). A cross-sectional study with qualitative and quantitative psychological assessment using semi-directed interviews and HADS, EORTC QLQ C30 and MINI-MAC scales...
March 9, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28276805/the-protective-effects-of-social-bonding-on-behavioral-and-pituitary-adrenal-axis-reactivity-to-chronic-mild-stress-in-prairie-voles
#7
Neal McNeal, Katherine M Appleton, Alan Kim Johnson, Melissa-Ann L Scotti, Joshua Wardwell, Rachel Murphy, Christina Bishop, Alison Knecht, Angela J Grippo
Positive social interactions may protect against stress. This study investigated the beneficial effects of pairing with a social partner on behaviors and neuroendocrine function in response to chronic mild stress (CMS) in 13 prairie vole pairs. Following 5 days of social bonding, male and female prairie voles were exposed to 10 days of CMS (mild, unpredictable stressors of varying durations, for instance, strobe light, white noise, and damp bedding), housed with either the social partner (paired group) or individually (isolated group)...
March 5, 2017: Stress: the International Journal on the Biology of Stress
https://www.readbyqxmd.com/read/28275643/a-translational-approach-to-clinical-practice-via-stress-responsive-glucocorticoid-receptor-signaling
#8
COMMENT
Mario F Juruena, Bruno Agustini, Anthony J Cleare, Allan H Young
A recent article by Kwan and colleagues could elegantly demonstrate the necessary interaction between neuronal serotonin (5-HT) systems and the hypothalamic-pituitary-adrenal (HPA) axis through glucocorticoid receptors (GR), producing an adequate stress response, in this case, responding to hypoxia with an increase in hematopoietic stem and progenitor cells (HSPC). There is an intricate system connecting brain, body and mind and this exchange is only possible when all these systems-nervous, endocrine, and immune-have receptors on critical cells to receive information (via messenger molecules) from each of the other systems...
2017: Stem Cell Investigation
https://www.readbyqxmd.com/read/28270247/gut-brain-actions-underlying-comorbid-anxiety-and-depression-associated-with-inflammatory-bowel-disease
#9
Áine Abautret-Daly, Elaine Dempsey, Adolfo Parra-Blanco, Carlos Medina, Andrew Harkin
Introduction Inflammatory bowel disease (IBD) is a chronic relapsing and remitting disorder characterised by inflammation of the gastrointestinal tract. There is a growing consensus that IBD is associated with anxiety- and depression-related symptoms. Psychological symptoms appear to be more prevalent during active disease states with no difference in prevalence between Crohn's disease and ulcerative colitis. Behavioural disturbances including anxiety- and depression-like symptoms have also been observed in animal models of IBD...
March 8, 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/28263537/chronic-unpredictable-mild-stress-paradigm-in-male-wistar-rats-effect-on-anxiety-and-depressive-like-behavior
#10
Romana Koprdova, Eszter Bögi, Kristína Belovičová, Natália Sedláčková, Monika Okuliarová, Eduard Ujházy, Mojmír Mach
OBJECTIVES: There are several models of depression. Chronic unpredictable mild stress (CMS) appears to have the greatest validity, although it is often being criticized for low reliability. METHODS: Male Wistar/DV rats were used in this study to assess our modified 2-week model of CMS as a combination of psychosocial, physical and metabolic stressors and to compare the effect of acute administration of venlafaxine (VFX) and diazepam (DZP), either in stress or no stress conditions...
December 18, 2016: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/28237543/hyper-and-hypocortisolism-in-bipolar-disorder-a-beneficial-influence-of-lithium-on-the-hpa-axis
#11
Martin Maripuu, Mikael Wikgren, Pontus Karling, Rolf Adolfsson, Karl-Fredrik Norrback
BACKGROUND: A hyperactive hypothalamic-pituitary-adrenal axis (HPA-axis) is a well-known phenomenon in bipolar disorder (BD). However, hypocortisolism has also been described and found associated with depression, low quality of life and cardiovascular risk factors in BD patients. Although the pathophysiology related to hypocortisolism in BD is largely unknown, hypocortisolism is associated with chronic stress exposure and after inducing an initial rise in cortisol long-term stress may result in a transition to hypocortisolism...
February 20, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28219987/a-unique-angiotensin-sensitive-neuronal-population-coordinates-neuroendocrine-cardiovascular-and-behavioral-responses-to-stress
#12
Annette D de Kloet, Lei Wang, Soledad Pitra, Helmut Hiller, Justin A Smith, Yalun Tan, Dani Nguyen, Karlena M Cahill, Colin Sumners, Javier E Stern, Eric G Krause
Stress elicits neuroendocrine, autonomic and behavioral responses that mitigate homeostatic imbalance and ensure survival; however, chronic engagement of such responses promotes psychological, cardiovascular and metabolic impairments. Over recent years, the renin-angiotensin system has emerged as a key mediator of stress responding and its related pathologies, but the neuronal circuits that orchestrate these interactions are not known. These studies combine the use of the Cre-recombinase/loxP system in mice with optogenetics to structurally and functionally characterize angiotensin type-1a receptor-containing neurons of the paraventricular nucleus of the hypothalamus, the goal being to determine the extent of their involvement in the regulation of stress responses...
February 20, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28219813/an-adverse-early-life-environment-can-enhance-stress-resilience-in-adulthood
#13
Sara Santarelli, Christoph Zimmermann, Georgia Kalideris, Sylvie L Lesuis, Janine Arloth, Andrés Uribe, Carine Dournes, Georgia Balsevich, Jakob Hartmann, Mercè Masana, Elisabeth B Binder, Dietmar Spengler, Mathias V Schmidt
Chronic stress is a major risk factor for depression. Interestingly, not all individuals develop psychopathology after chronic stress exposure. In contrast to the prevailing view that stress effects are cumulative and increase stress vulnerability throughout life, the match/mismatch hypothesis of psychiatric disorders. The match/mismatch hypothesis proposes that individuals who experience moderate levels of early life psychosocial stress can acquire resilience to renewed stress exposure later in life. Here, we have tested this hypothesis by comparing the developmental effects of 2 opposite early life conditions, when followed by 2 opposite adult environments...
February 7, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28215162/gut-brain-axis-role-of-lipids-in-the-regulation-of-inflammation-pain-and-cns-diseases
#14
Roberto Russo, Claudia Cristiano, Carmen Avagliano, Carmen De Caro, Giovanna La Rana, Giuseppina Mattace Raso, Roberto Berni Canani, Rosaria Meli, Antonio Calignano
The human gut is a composite anaerobic environment with a large, diverse and dynamic enteric microbiota, represented by more than 100 trillion microorganisms, including at least 1000 distinct species. The discovery that a different microbial composition can influence behavior and cognition, and in turn the nervous system can indirectly influence enteric microbiota composition, has significantly contributed to establish the well-accepted concept of gut-brain axis. This hypothesis is supported by several evidence showing mutual mechanisms, which involve the vague nerve, the immune system, the hypothalamic-pituitary-adrenal (HPA) axis modulation and the bacteria-derived metabolites...
February 16, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28215154/stress-and-salivary-glands
#15
Beáta Kerémi, Anita Beck, Tibor Károly Fábián, Gábor Fábián, Géza Szabó, Ákos Nagy, Gábor Varga
Salivary glands produce a bicarbonate-rich fluid containing digestive and protective proteins and other components to be delivered into the gastrointestinal tract. Its function is under strict control of the autonomic nervous system. Salivary electrolyte and fluid secretion is primarily controlled by parasympathetic activity, while protein secretion is primaily triggered by sympathetic stimulation. Stress activates the hypothalamic - pituitary - adrenal axis. The peripheral limb of this axis is the efferent sympathetic/adrenomedullary system...
February 15, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28202252/what-worries-parents-of-a-child-with-autism-evidence-from-a-biomarker-for-chronic-stress
#16
Vicki Bitsika, Christopher F Sharpley, Nicholas M Andronicos, Linda L Agnew
BACKGROUND: Previous studies have reported correlations between various aspects of the behaviour and symptomatology of children with Autism Spectrum Disorder (ASD) and their parents' self-reports of stress via standardised scales. AIMS: To extend that literature, a physiological index of parental chronic stress was used instead of their self-reports-dysregulation of the Diurnal Rhythm (DR) of the Hypothalamic-Pituitary-Adrenal (HPA) axis. METHODS: A sample of 149 parents of a child with ASD provided salivary cortisol at the predicted time of daily maximum cortisol concentration and at a time of daily lower concentration...
March 2017: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/28185964/experimental-occlusal-disharmony-a-promoting-factor-for-anxiety-in-rats-under-chronic-psychological-stress
#17
Xuan Tang, Jian Li, Ting Jiang, Shu-Hui Han, Dong-Yuan Yao
BACKGROUND AND PURPOSE: Clinically, patients under chronic psychological stress (PS) appear to be more susceptible to occlusal disharmony (OD) compared with those without PS. OD was proved to introduce anxiety-like stress. Therefore, the purpose of the study was to investigate whether OD would affect psychological stress-induced anxiety and its underlying mechanisms. METHODS: Chronic PS was induced by a communication box, and OD was produced by bonding a 0.3mm-thick crown on the right maxillary first molar of male Sprague-Dawley rats...
April 3, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28181173/hypothalamic-pituitary-adrenal-reactivity-to-acute-stress-an-investigation-into-the-roles-of-perceived-stress-and-family-resources
#18
Ezemenari M Obasi, Elizabeth A Shirtcliff, Lucia Cavanagh, Kristen L Ratliff, Delishia M Pittman, Jessica J Brooks
Rurally situated African Americans suffer from chronic exposure to stress that may have a deleterious effect on health outcomes. Unfortunately, research on potential mechanisms that underlie health disparities affecting the African American community has received limited focus in the scientific literature. This study investigated the relationship between perceived stress, family resources, and cortisol reactivity to acute stress. A rural sample of African American emerging adults (N = 60) completed a battery of assessments, the Trier Social Stress Test (TSST), and provided four samples of salivary cortisol: prior to receiving TSST instructions, prior to conducting the speech task, immediately following the TSST, and 15-20 min following the TSST...
February 8, 2017: Prevention Science: the Official Journal of the Society for Prevention Research
https://www.readbyqxmd.com/read/28179626/hypothalamic-pituitary-adrenal-axis-dysregulation-and-double-product-increases-potentiate-ischemic-heart-disease-risk-in-a-black-male-cohort-the-sabpa-study
#19
Leoné Malan, Christiaan E Schutte, Ala'a Alkerwi, Saverio Stranges, Nicolaas T Malan
Emotional distress has been associated with a poorer prognosis in myocardial infarction patients. Elevated adrenocorticotrophic hormone (ACTH), lower cortisol, dehydroepiandrosterone sulfate (DHEAS) and cortisol:DHEAS, as measures of emotional distress, might correlate with silent myocardial ischemia (SMI) and workload. Thus, we assessed the relationship between emotional distress, SMI and double product (systolic blood pressure (SBP) × heart rate). Cross-sectional South African biethnic single-set cohorts (N=378), aged 44...
February 9, 2017: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/28164167/neonatal-maternal-separation-increases-susceptibility-to-experimental-colitis-and-acute-stress-exposure-in-male-mice
#20
Isabella M Fuentes, Natalie K Walker, Angela N Pierce, Briana R Holt, Elizabeth R Di Silvestro, Julie A Christianson
Experiencing early life stress can result in maladjusted stress response via dysregulation of the hypothalamic-pituitary-adrenal axis and serves as a risk factor for developing chronic pelvic pain disorders. We investigated whether neonatal maternal separation (NMS) would increase susceptibility to experimental colitis or exposure to acute or chronic stress. Male mice underwent NMS from postnatal day 1-21 and as adults were assessed for open field behavior, hindpaw sensitivity, and visceromotor response (VMR) to colorectal distension (CRD)...
December 2016: IBRO Rep
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