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Ying Huang, Xiaodong Liu, Zheng Cui, Daniel Wiegmann, Giuliana Niro, Christian Ducho, Yuan Song, Zhaoyong Yang, Steven G Van Lanen
Capuramycins are antimycobacterial antibiotics that consist of a modified nucleoside named uridine-5'-carboxamide (CarU). Previous biochemical studies have revealed that CarU is derived from UMP, which is first converted to uridine-5'-aldehyde in a reaction catalyzed by the dioxygenase CapA and subsequently to 5'-C-glycyluridine (GlyU), an unusual β-hydroxy-α-amino acid, in a reaction catalyzed by the pyridoxal-5'-phosphate (PLP)-dependent transaldolase CapH. The remaining steps that are necessary to furnish CarU include decarboxylation, O atom insertion, and oxidation...
January 17, 2018: Proceedings of the National Academy of Sciences of the United States of America
Lasse Ishøi, Per Hölmich, Per Aagaard, Kristian Thorborg, Thomas Bandholm, Andreas Serner
This assessor-blinded, randomized controlled superiority trial investigated the efficacy of the 10-week Nordic Hamstring exercise (NHE) protocol on sprint performance in football players. Thirty-five amateur male players (age: 17-26 years) were randomized to a do-as-usual control group (CG; n = 17) or to 10-weeks of supervised strength training using the NHE in-season (IG; n = 18). A repeated-sprint test, consisting of 4 × 6 10 m sprints, with 15 s recovery period between sprints and 180 s between sets, was conducted to evaluate total sprint time as the primary outcome...
December 1, 2017: Journal of Sports Sciences
Milena Di Leo, Maria Chiara Petrone, Raffaella Alessia Zuppardo, Giulia Martina Cavestro, Paolo Giorgio Arcidiacono, Pier Alberto Testoni, Alberto Mariani
BACKGROUND: Magnetic resonance cholangio-pancreatography (MRCP) findings in people with chronic asymptomatic pancreatic hyperenzymemia (CAPH) have shifted the hypothesis that CAPH is always non-pathological. However, there have been no studies including both secretin-MRCP (S-MRCP) and endoscopic ultrasonography (EUS) to examine the pancreatic morphology in these subjects. AIM: To prospectively assess the diagnostic approach for CAPH using both pancreatic EUS and S-MRCP...
November 2016: Digestive and Liver Disease
Olena O Litsis, Vladimir A Ovchynnikov, Vasyl P Scherbatskii, Sergiy G Nedilko, Tatiana Yu Sliva, Viktoriya V Dyakonenko, Oleg V Shishkin, Valentine I Davydov, Paula Gawryszewska, Vladimir M Amirkhanov
A series of complexes Ln(Pip)3(Phen) (Ln(iii) = La, Ce-Nd, Sm-Lu, Y; HPip (CAPh type ligand) = 2,2,2-trichloro-N-(dipiperidin-1-yl-phosphoryl)acetamide, Phen = 1,10-phenanthroline) has been synthesized. The lanthanum(iii) doped europium(iii) complexes ([LaxEu1-x(Pip)3(Phen)], x = 0.99, 0.95, 0.50) have been obtained by the co-crystallization method. The complexes have been characterized by means of X-ray diffraction, IR, (1)H and (31)P-NMR and absorption spectroscopy. Emission and excitation luminescence spectra were recorded at 295 and 77 K...
September 21, 2015: Dalton Transactions: An International Journal of Inorganic Chemistry
Zeno E Franco, Syed M Ahmed, Cheryl A Maurana, Mia C DeFino, Devon D Brewer
INTRODUCTION: Social Network Analysis (SNA) provides an important, underutilized approach to evaluating Community Academic Partnerships for Health (CAPHs). This study examines administrative data from 140 CAPHs funded by the Healthier Wisconsin Partnership Program (HWPP). METHODS: Funder data was normalized to maximize number of interconnections between funded projects and 318 non-redundant community partner organizations in a dual mode analysis, examining the period from 2003-2013...
August 2015: Clinical and Translational Science
Manish Nepal, Shankar Thangamani, Mohamed N Seleem, Jean Chmielewski
An extended cationic and amphiphilic polyproline helix (CAPH) is described with a dual mode of action: effective cell penetration of human macrophages, and potent antimicrobial activity in vitro against both Gram-positive and negative pathogens, including Acinetobacter baumannii, Escherichia coli O157 and Bacillus anthracis. This dual action was successfully combined to clear pathogenic bacteria (Brucella and Salmonella) residing within macrophages.
June 7, 2015: Organic & Biomolecular Chemistry
Atsushi Shiga, Isao Narama
To characterize the hepatic lesions in Fischer 344 (F344) rats afflicted with large granular lymphocyte (LGL) leukemia, the livers of rats with LGL leukemia at various stages were examined histopathologically and immunohistochemically. The morphologic features in the livers of rats afflicted with LGL leukemia were diffuse, uniform-sized, granular, or micronodular lesions consisting of hepatocytes showing centrilobular atrophy and perilobular hypertrophy (CAPH) without fibrosis. With progression in the stage of the LGL leukemia, the severity of the CAPH of hepatocytes increased resulting in fatty change and/or single-cell necrosis, along with compensatory hyperplasia of the hepatocytes, finally resulting in lesions similar to those seen in nodular regenerative hyperplasia (NRH) in the human liver...
August 2015: Toxicologic Pathology
Victor Hernandez-Gordillo, Iris Geisler, Jean Chmielewski
We report a dimerization strategy to enhance the antibacterial potency of an otherwise weak cationic amphiphilic polyproline helical (CAPH) peptide. Overall, the dimeric CAPHs were more active against Escherichia coli and Staphylococcus aureus than the monomeric counterpart, reaching up to a 60-fold increase in potency. At their minimum inhibitory concentration (MIC), the dimeric peptides demonstrated no hemolytic activity or bacterial membrane disruption as monitored by β-galactosidase release in E. coli...
January 15, 2014: Bioorganic & Medicinal Chemistry Letters
Antonio Amodio, Riccardo Manfredi, Anna Maria Katsotourchi, Armando Gabbrielli, Luigi Benini, Roberto Pozzi Mucelli, Italo Vantini, Luca Frulloni
OBJECTIVES: Chronic asymptomatic pancreatic hyperenzymemia (CAPH) has been described since 1996 as a benign disease. Recent studies described pathological findings at magnetic resonance cholangiopancreatography with secretin stimulation (s-MRCP) in more than half of the CAPH subjects. The aim of this study was to investigate the frequency and clinical relevance of s-MRCP findings in patients with CAPH. METHODS: Subjects prospectively enrolled from January 2005 to December 2010 underwent s-MRCP and biochemical tests routinely performed...
July 2012: American Journal of Gastroenterology
Deanna Kalafut, Tiffani N Anderson, Jean Chmielewski
The development of cell penetrating peptides (CPPs) for the cellular delivery of attached cargo is an area of growing interest. Many CPPs, however, are found trapped within endosomes, thereby limiting their use as drug delivery agents with sub-cellular applications. Herein, we detail the properties of a highly efficient class of CPPs, cationic amphiphilic polyproline helices (CAPHs), that are found localized to the mitochondria by direct transport into cells.
January 1, 2012: Bioorganic & Medicinal Chemistry Letters
Iris M Geisler, Jean Chmielewski
PURPOSE: Efficient delivery of therapeutic biopolymers across cell membranes remains a daunting challenge. The development of cell-penetrating peptides (CPPs) has been useful; however, many CPPs are found trapped within endosomes, limiting their use as delivery agents. We optimize a class of CPPs, cationic amphiphilic polyproline helices (CAPHs), for direct transport into cells with mitochondrial localization through dimerization. METHODS: The CAPH P11LRR used for this study has been found to enter cells by two distinct pathways: an endocytotic pathway was favored at low concentrations; internalization by direct transport was observed at higher concentrations...
November 2011: Pharmaceutical Research
Olena O Litsis, Vladimir A Ovchynnikov, Tetyana Yu Sliva, Irina S Konovalova, Vladimir M Amirkhanov
The title compound, [Na(2)(C(10)H(16)Cl(3)N(3)O(4)P)(2)(H(2)O)(2)](n), can be considered as a two-dimensional coordination polymer in which one-dimensional chains are connected to each other by inter-molecular C-H⋯O hydrogen bonds involving the water mol-ecules. The Na(I) ion is five-coordinated in a distorted trigonal-bipyramidal geometry. The connection between the two Na(I) ions is facilitated by the two μ-O atoms of the carbonyl group of the 2,2,2-trichloro-N-(dimorpholino-phosphor-yl)acetamide (CAPh) ligand...
2010: Acta Crystallographica. Section E, Structure Reports Online
N C Sharma, J Qaqish, P A Walters, J Grender, A R Biesbrock
OBJECTIVE: To assess and compare the plaque removal efficacy of five different Oral-B manual toothbrushes: CrossAction Pro-Health (CAPH), CrossAction (CA), Exceed (EX), Advantage 123 (ADV 123), and Indicator (IND). METHODS: This was a single-use, five-treatment, examiner-blind, randomized, five-period (visit) crossover study, with 10 different treatment sequences (groups) that determined the order in which the five toothbrushes were assigned at study visits. Three toothbrushes had an advanced CrissCross bristle design (CAPH, CA, EX), while two had more standard designs with straight bristles (ADV 123 and IND)...
2010: Journal of Clinical Dentistry
David Bowsher, C Geoffrey Woods, Adeline K Nicholas, Ofelia M Carvalho, Carol E Haggett, Brian Tedman, James M Mackenzie, Daniel Crooks, Nasir Mahmood, J Aidan Twomey, Samantha Hann, Dilwyn Jones, James P Wymer, Phillip J Albrecht, Charles E Argoff, Frank L Rice
Congenital absence of pain perception is a rare phenotype. Here we report two unrelated adult individuals who have a previously unreported neuropathy consisting of congenital absence of pain with hyperhidrosis (CAPH). Both subjects had normal intelligence and productive lives despite failure to experience pain due to broken bones, severe cold or burns. Functional assessments revealed that both are generally hypesthetic with thresholds greater than two standard deviations above normal for a several of modalities in addition to noxious stimuli...
December 15, 2009: Pain
Huiming Lin, Guangshan Zhu, Jiaojiao Xing, Bo Gao, Shilun Qiu
In this paper, polymer-mesoporous silica nanoparticles have been synthesized by a dual-template technology. Cationic polymer quaternized poly[bis(2-chloroethyl)ether-alt-1,3-bis[3-(dimethylamino)propyl]urea] (PEPU) and anionic surfactant sodium dodecyl sulfate (SDS) were used to form a homogeneous comicelle system to induce mesoporous silica spherical nanoparticles with diameters of 50-180 nm. The formation mechanism was studied by transmission electron microscopy (TEM), which suggested that PEPU played a cotemplate role in the synthesis process, and no mesoporous structure was generated without it...
September 1, 2009: Langmuir: the ACS Journal of Surfaces and Colloids
G Wendt-Nordahl, A P Evan, M Spahn, T Knoll
Calcium oxalate (CaOx) urolithiasis is a very common disorder. Surprisingly, the pathogenetic mechanisms leading to CaOx stone formation have been largely unknown so far. The long-accepted simple explanation by an exceeding of the solubility product of lithogenic substances in the urine cannot sufficiently describe the complex processes. Deviating from the hypothesis that proclaims that the initial crystal deposition takes place in the lumens of renal tubules, new insights suggest a primary plaque formation in the interstitial space of the renal papilla...
May 2008: Der Urologe. Ausg. A
Nobuhiko Samoto, Masakazu Kozuma, Toshio Tokuhisa, Kunio Kobayashi
Although several quantitative magnetic resonance (MR) diagnostic criteria for discoid lateral meniscus (DLM) have been described, there are no criteria by which to estimate the size of the medial meniscus. We define a medial meniscus that exceeds the normal size as a "large medial meniscus" (LMM), and the purpose of this study is to establish the quantitative MR diagnostic criteria for LMM. The MR imaging findings of 96 knees with arthroscopically confirmed intact semilunar lateral meniscus (SLM), 18 knees with intact DLM, 105 knees with intact semilunar medial meniscus (SMM) and 4 knees with torn LMM were analyzed...
November 2006: Magnetic Resonance Imaging
Hajnalka Jankovics, Claudio Pettinari, Fabio Marchetti, Erzsébet Kamu, László Nagy, Sergei Troyanov, Lorenzo Pellerito
Diorganotin(IV) complexes R(2)Sn(cap) (capH(2)=N-[(S)-3-mercapto-2-methylpropionyl]-L-proline; R=Me, Et, n-Bu and t-Bu) were prepared and characterised. The FTIR and Raman spectra demonstrated that the organotin(IV) moieties interact with the [S] atom of the ligand, while the other coordination sites are the carboxylate and the amide -CO groups. Mössbauer Delta data showed that the diorganotin(IV) compounds adopt slightly distorted trigonal-bipyramidal (tbp) geometry. A single-crystal X-ray study was performed on the compound Me(2)Sn(cap): the Sn atom is five-coordinated in a distorted tbp environment, with two [O] atoms in the axial positions and the [S] and two [C] atoms in the equatorial (eq) plane...
December 1, 2003: Journal of Inorganic Biochemistry
M P Geijo Martínez, A M Díaz de Tuesta Chow-Quan, C Rosa Herranz, C Gómez Criado, J F Dimas Nuñez, F Saiz García
OBJECTIVE: To compare the effectiveness and security of levofloxacin treatment in front betalactamic therapy in patient with community-acquired pneumonia that require hospitalization (CAPH). PATIENT AND METHODS: A prospective and randomized study along a year from 49 patients diagnosed of (CAPH) that were admitted in the Internal Medicine Service. The patients were assigned randomly to receive.-I: cefotaxime or ceftriaxone, II: amoxicillin/clavulanate (both could be associated or not with a macrolide) or III: levofloxacin...
December 2002: Anales de Medicina Interna: Organo Oficial de la Sociedad Española de Medicina Interna
Nobuhiko Samoto, Masakazu Kozuma, Toshio Tokuhisa, Kunio Kobayashi
To establish the quantitative MR diagnostic criteria for discoid lateral meniscus, MR imaging of 60 knees with arthroscopically confirmed discoid lateral menisci and 134 knees with semilunar lateral menisci were analyzed. Following four quantitative parameters were measured. (1) Meniscal width (MW): The minimum meniscal width on the coronal slice. (2) Ratio of the meniscus to the tibia (RMT): The ratio of minimum meniscal width to maximum tibial width on the coronal slice. (3) Percent coverage of the meniscus (PCM): The ratio of the sum of the width of the anterior and posterior horns to the meniscal diameter on the sagittal slice showing the maximum meniscal diameter...
January 2002: Magnetic Resonance Imaging
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