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Colistin-resistant strain bacteria

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https://www.readbyqxmd.com/read/28748397/activity-of-the-novel-siderophore-cephalosporin-cefiderocol-against-multidrug-resistant-gram-negative-pathogens
#1
J Dobias, V Dénervaud-Tendon, L Poirel, P Nordmann
The novel siderophore cephalosporin cefiderocol (S-649266) with potent activity against Gram-negative pathogens was recently developed (Shionogi & Co., Ltd.). Here, we evaluated the activity of this new molecule and comparators against a collection of previously characterized Gram-negative isolates using broth microdilution panels. A total of 753 clinical multidrug-resistant Gram-negative isolates collected from hospitals worldwide were tested against cefiderocol and antibiotic comparators (ceftolozane-tazobactam [CT], meropenem [MEM], ceftazidime [CAZ], ceftazidime-avibactam [CZA], colistin [CST], aztreonam [ATM], amikacin [AMK], ciprofloxacin [CIP], cefepime [FEP], and tigecycline [TGC]) for their susceptibility...
July 26, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28671537/the-distribution-of-carbapenem-and-colistin-resistance-in-gram-negative-bacteria-from-the-tamil-nadu-region-in-india
#2
Prasanth Manohar, Thamaraiselvan Shanthini, Ramankannan Ayyanar, Bulent Bozdogan, Aruni Wilson, Ashok J Tamhankar, Ramesh Nachimuthu, Bruno S Lopes
PURPOSE: The occurrence of carbapenem- and colistin-resistance among Gram-negative bacteria is increasing worldwide. The aim of this study was to understand the distribution of carbapenem- and colistin-resistance in two areas in Tamil Nadu, India. METHODOLOGY: The clinical isolates (n=89) used in this study were collected from two diagnostic centres in Tamil Nadu, India. The bacterial isolates were screened for meropenem- and colistin-resistance. Further, resistance genes blaNDM-1, blaOXA-48-like, blaIMP, blaVIM, blaKPC, mcr-1 and mcr-2 and integrons were studied...
July 3, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28671522/molecular-epidemiology-of-beta-lactamase-producing-nosocomial-gram-negative-pathogens-from-north-and-south-indian-hospitals
#3
Surbhi Khurana, Purva Mathur, Arti Kapil, Chithra Valsan, Bijayini Behera
PURPOSE: Resistant Gram-negative bacterial (GNB) infections, apart from tremendously escalating the cost of treatment, are a cause for substantial morbidity and mortality among hospitalized patients. Such bacteria are rapidly acquiring resistance to many antimicrobial agents, especially the beta-lactams which are the most frequently prescribed antimicrobials in hospital and community patient care settings, and now also to colistin; a last-line drug to treat infections with such bacteria...
July 3, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28668680/antimicrobial-activities-of-lcb10-0200-a-novel-siderophore-cephalosporin-against-the-clinical-isolates-of-pseudomonas-aeruginosa-and-other-pathogens
#4
Sang-Hun Oh, Hee-Soo Park, Hye-Shin Kim, Jeong-Yul Yun, Kyuman Oh, Young-Lag Cho, Jin-Hwan Kwak
Infections caused by multidrug-resistant bacteria, including Pseudomonas aeruginosa, are threating public health worldwide. Therefore, a novel antibacterial agent is needed for treating these infections. Here, we investigated the in vitro and in vivo activities of a novel siderophore-conjugated cephalosporin LCB10-0200 against the clinical isolates of Gram-negative baeria, including multidrug-resistant P. aeruginosa. In vitro susceptibility to LCB10-0200 was assessed by performing a two-fold agar dilution method, as described by Clinical and Laboratory Standards Institute...
June 28, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28666753/first-report-of-an-e-coli-strain-from-swine-carrying-an-oxa-181-carbapenemase-and-colistin-resistance-determinant-mcr-1
#5
Sandra Pulss, Torsten Semmler, Ellen Prenger-Berninghoff, Rolf Bauerfeind, Christa Ewers
Plasmid-mediated resistance in Enterobacteriaceae against carbapenems and colistin represents an emerging threat for public health. Although animals have been identified as a relevant source of multidrug-resistant (MDR) bacteria, there are only few reports about the presence of carbapenemases in animal isolates. Using Mueller-Hinton agar with meropenem, 7,850 fecal E. coli isolates obtained from 2,160 pigs were screened for carbapenem non-susceptibility. Eleven isolates showed growth on meropenem agar but only two proved positive for a carbapenemase gene, namely blaOXA-48-like, by PCR...
June 27, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28663698/efficacy-of-mastoparan-af-alone-and-in-combination-with-clinically-used-antibiotics-on-nosocomial-multidrug-resistant-acinetobacter-baumannii
#6
Chun-Hsien Lin, Mong-Chuan Lee, Jason T C Tzen, Hsien-Ming Lee, Sam-Min Chang, Wu-Chun Tu, Chuen-Fu Lin
Emergence of multidrug-resistant Acinetobacter baumannii (MDRAB) has become a critical clinical problem worldwide and limited therapeutic options for infectious diseases caused by MDRAB. Therefore, there is an urgent need for the development of new antimicrobial agents or alternative therapy to combat MDRAB infection. The aim of this study was to investigate effects of Mastoparan-AF (MP-AF), an amphipathic peptide isolated from the hornet venom of Vespa affinis with broad-spectrum antimicrobial activity, on MDRAB...
July 2017: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/28655818/novel-plasmid-mediated-colistin-resistance-gene-mcr-3-in-escherichia-coli
#7
Wenjuan Yin, Hui Li, Yingbo Shen, Zhihai Liu, Shaolin Wang, Zhangqi Shen, Rong Zhang, Timothy R Walsh, Jianzhong Shen, Yang Wang
The mobile colistin resistance gene mcr-1 has attracted global attention, as it heralds the breach of polymyxins, one of the last-resort antibiotics for the treatment of severe clinical infections caused by multidrug-resistant Gram-negative bacteria. To date, six slightly different variants of mcr-1, and a second mobile colistin resistance gene, mcr-2, have been reported or annotated in the GenBank database. Here, we characterized a third mobile colistin resistance gene, mcr-3 The gene coexisted with 18 additional resistance determinants in the 261-kb IncHI2-type plasmid pWJ1 from porcine Escherichia colimcr-3 showed 45...
June 27, 2017: MBio
https://www.readbyqxmd.com/read/28638248/evaluation-of-microorganisms-causing-ventilator-associated-pneumonia-in-a-pediatric-intensive-care-unit
#8
Ayse Betul Ergul, Serife Cetin, Yasemin Ay Altintop, Sefika Elmas Bozdemir, Alper Ozcan, Umit Altug, Hasan Samsa, Yasemin Altuner Torun
OBJECTIVE: The aim of this study was to identify microorganisms causing ventilator-associated pneumonia (VAP) and also study the antibiotic resistance/susceptibility. MATERIALS AND METHODS: We retrospectively assessed microorganisms isolated from patients diagnosed with VAP in a pediatric intensive care unit between January 1, 2014, and June 30, 2016. RESULTS: We included 44 patients diagnosed with VAP. The prevalence thereof was 8.6 patients per 1,000 ventilator days...
June 2017: Eurasian Journal of Medicine
https://www.readbyqxmd.com/read/28626539/resistance-to-colistin-in-klebsiella-pneumoniae-a-4-0-strain
#9
REVIEW
Guido Granata, Nicola Petrosillo
The global rise of multidrug-resistant gram-negative bacteria represents an increasing threat to patient safety. From the first observation of a carbapenem-resistant gram-negative bacteria a global spread of extended-spectrum beta-lactamases and carbapenemases producing Klebsiella pneumoniae has been observed. Treatment options for multidrug-resistant K. pneumoniae are actually limited to combination therapy with some aminoglycosides, tigecycline and to older antimicrobial agents. Unfortunately, the prevalence of colistin-resistant and tigecycline-resistant K...
May 31, 2017: Infectious Disease Reports
https://www.readbyqxmd.com/read/28623298/constraint-based-modeling-identifies-new-putative-targets-to-fight-colistin-resistant-a-baumannii-infections
#10
Luana Presta, Emanuele Bosi, Leila Mansouri, Lenie Dijkshoorn, Renato Fani, Marco Fondi
Acinetobacter baumannii is a clinical threat to human health, causing major infection outbreaks worldwide. As new drugs against Gram-negative bacteria do not seem to be forthcoming, and due to the microbial capability of acquiring multi-resistance, there is an urgent need for novel therapeutic targets. Here we have derived a list of new potential targets by means of metabolic reconstruction and modelling of A. baumannii ATCC 19606. By integrating constraint-based modelling with gene expression data, we simulated microbial growth in normal and stressful conditions (i...
June 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28616507/the-first-report-of-escherichia-fergusonii-isolated-from-non-human-primates-in-africa
#11
Barbara Glover, Jeanette Wentzel, Akinbowale Jenkins, Moritz Van Vuuren
The aim of this study was to determine the resistance phenotypes of selected enteric bacteria isolated from non-human primates at a wildlife-human interface. Bacterial isolates from faecal samples of non-human primates at two wildlife rehabilitation centres in South Africa were screened for the presence of Escherichia coli. The biochemical characterisation of E. coli and E. coli-like bacteria revealed both adonitol positive and sorbitol negative strains - a unique characteristic of Escherichia fergusonii and Escherichia coli K99...
June 2017: One Health
https://www.readbyqxmd.com/read/28578555/infections-due-to-acinetobacter-baumannii-in-the-icu-treatment-options
#12
Joseph P Lynch, George G Zhanel, Nina M Clark
Bacteria within the genus Acinetobacter (principally A. baumannii-calcoaceticus complex [ABC]) are gram-negative coccobacilli that may cause nosocomial infections in critically ill or debilitated patients (particularly ventilator-associated pneumonia and infections of the bloodstream, urinary tract, and wounds). Treatment of Acinetobacter infections is difficult, as Acinetobacter spp. are intrinsically resistant to multiple antimicrobial agents, and have a remarkable ability to acquire new resistance determinants via mechanisms that include plasmids, transposons, integrons, and resistance islands...
June 2017: Seminars in Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28507112/mcr-1-and-oxa-48-in-vivo-acquisition-in-kpc-producing-escherichia-coli-after-colistin-treatment
#13
Racha Beyrouthy, Frederic Robin, Aude Lessene, Igor Lacombat, Laurent Dortet, Thierry Naas, Valérie Ponties, Richard Bonnet
The spread of mcr-1-encoding plasmids into carbapenem-resistant Enterobacteriaceae raises concerns about the emergence of untreatable bacteria. We report the acquisition of mcr-1 in a carbapenem- resistant E. coli after a 3-week course of colistin in a patient repatriated to France from Portugal. Whole-genome sequencing revealed that the KPC-producing E. coli strain acquired two plasmids, an IncL OXA-48-encoding plasmid and an IncX4 mcr-1-encoding plasmid. This is the first report of mcr-1 in carbapenemase-encoding bacteria in France...
May 15, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28503325/ceftolozane-tazobactam-for-febrile-uti-due-to-multidrug-resistant-pseudomonas-aeruginosa-in-a-patient-with-neurogenic-bladder
#14
Aurélien Dinh, Benjamin Davido, Ruxandra Calin, Julie Paquereau, Clara Duran, Frédérique Bouchand, Véronique Phé, Emmanuel Chartier-Kastler, Martin Rottman, Jérôme Salomon, Patrick Plésiat, Anaïs Potron
INTRODUCTION: Urinary tract infections (UTI) are a major public health problem among spinal cord injury (SCI) patients. They frequently involve multidrug-resistant (MDR) bacteria. Ceftolozane/tazobactam (C/T) is a novel antibiotic combination approved for complicated intra-abdominal and UTI caused by Gram-positive and Gram-negative organisms, including some MDR strains. Little is known about the use of this agent for complicated febrile UTI occurring among SCI patients with neurogenic bladder due to MDR Pseudomonas aeruginosa (PSA)...
2017: Spinal Cord Series and Cases
https://www.readbyqxmd.com/read/28470337/synergistic-activity-of-synthetic-n-terminal-peptide-of-human-lactoferrin-in-combination-with-various-antibiotics-against-carbapenem-resistant-klebsiella-pneumoniae-strains
#15
P Morici, W Florio, C Rizzato, E Ghelardi, A Tavanti, G M Rossolini, A Lupetti
The spread of multi-drug resistant (MDR) Klebsiella pneumoniae strains producing carbapenemases points to a pressing need for new antibacterial agents. To this end, the in-vitro antibacterial activity of a synthetic N-terminal peptide of human lactoferrin, further referred to as hLF1-11, was evaluated against K. pneumoniae strains harboring different carbapenemase genes (i.e. OXA-48, KPC-2, KPC-3, VIM-1), with different susceptibility to colistin and other antibiotics, alone or in combination with conventional antibiotics (gentamicin, tigecycline, rifampicin, clindamycin, and clarithromycin)...
May 3, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28437232/epidemiological-physiological-and-molecular-characteristics-of-a-brazilian-collection-of-carbapenem-resistant-acinetobacter-baumannii-and-pseudomonas-aeruginosa
#16
Vanessa Cordeiro Dias, Juliana Alves Resende, André Netto Bastos, Lucas Quinet De Andrade Bastos, Victor Quinet De Andrade Bastos, Ricardo Villela Bastos, Cláudio Galuppo Diniz, Vânia Lúcia Da Silva
Nonfermenting Gram-negative bacteria such as Pseudomonas aeruginosa and Acinetobacter baumannii are widespread in the environment and are increasingly associated with nosocomial infections, often associated with multidrug-resistance phenotypes. This study aimed to evaluate epidemiological, physiological, and molecular characteristics of carbapenem resistance in P. aeruginosa and A. baumannii. In total, 63 nonreplicated strains (44 A. baumannii and 19 P. aeruginosa) were isolated from hospitalized patients. Antimicrobial resistance patterns, biocide tolerance, oxidative stress, hemolytic activity, and biofilm formation were assessed...
February 24, 2017: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/28361526/ceftolozane-tazobactam-for-the-treatment-of-ventilator-associated-infections-by-colistin-resistant-pseudomonas-aeruginosa
#17
F Álvarez Lerma, R Muñoz Bermudez, S Grau, M P Gracia Arnillas, L Sorli, L Recasens, M Mico García
The use of colistin for the treatment of multiresistant bacteria has led to the emergence of colistin-resistant strains of Gram-negative bacilli. Treatment of infections caused by these pan-drug-resistant bacteria is difficult owing to the paucity of effective antibiotics. We report two cases of ventilator-associated respiratory infection caused by pan-drug-resistant, colistin-resistant Pseudomonas aeruginosa that were successfully treated with ceftolozane-tazobactam.
March 29, 2017: Revista Española de Quimioterapia: Publicación Oficial de la Sociedad Española de Quimioterapia
https://www.readbyqxmd.com/read/28348778/veb-1-extended-spectrum-%C3%AE-lactamase-producing-multidrug-resistant-proteus-mirabilis-sepsis-outbreak-in-a-neonatal-intensive-care-unit-in-india-clinical-and-diagnostic-implications
#18
Sarika Jain, Rajni Gaind, Charu Kothari, Rachna Sehgal, A Shamweel, S S Thukral, Harish K Chellani
INTRODUCTION: Extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae, multidrug-resistant (MDR) pathogens, are increasingly implicated in nosocomial outbreaksworldwide, particularly in neonatal intensive care units (NICUs). Proteus mirabilis is an uncommon nosocomial pathogen causing sepsis in neonates. CASE PRESENTATION: We report an outbreak of ESBL-positive MDR P. mirabilis sepsis involving five babies within 10 days in a NICU, which was promptly detected and managed...
August 2016: JMM Case Reports
https://www.readbyqxmd.com/read/28344161/cross-resistance-to-human-cationic-antimicrobial-peptides-and-to-polymyxins-mediated-by-the-plasmid-encoded-mcr-1
#19
J Dobias, L Poirel, P Nordmann
OBJECTIVES: To evaluate whether acquired resistance to cationic antimicrobial peptide (CAMP) group molecules, being normal components of the human immune system, may select co-resistance to antibiotic peptides such as polymyxins, considering they share the same mechanism of action. We aimed to evaluate strains producing the recently identified plasmid-encoded polymyxin resistance determinant MCR-1, which is a phosphoethanolamine transferase that modifies the lipopolysaccharide structure of Gram-negative bacteria...
March 23, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28291943/a-new-combination-of-a-pleuromutilin-derivative-and-doxycycline-for-treatment-of-multidrug-resistant-acinetobacter-baumannii
#20
Shajila Siricilla, Katsuhiko Mitachi, Junshu Yang, Shakiba Eslamimehr, Maddie R Lemieux, Bernd Meibohm, Yinduo Ji, Michio Kurosu
Multidrug-resistant (MDR) Acinetobacter baumannii is one of the most difficult Gram-negative bacteria to treat and eradicate. In a cell-based screening of pleuromutilin derivatives against a drug sensitive A. baumannii strain, new molecules (2-4) exhibit bacteriostatic activity with 3.13 μg/mL concentration and 1 shows bactericidal activity with an MBC of 6.25 μg/mL. The pleuromutilin derivative 1 displays strong synergistic effects with doxycycline in a wide range of concentrations. A 35/1 ratio of 1 and doxycycline (1-Dox 35/1) kills drug susceptible A...
April 13, 2017: Journal of Medicinal Chemistry
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