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Colistin-resistant strain bacteria

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https://www.readbyqxmd.com/read/29296190/expression-characteristics-of-the-plasmid-borne-mcr-1-colistin-resistance-gene
#1
Haifang Zhang, Minhui Miao, Jieting Yan, Min Wang, Yi-Wei Tang, Barry N Kreiswirth, Xia Zhang, Liang Chen, Hong Du
The plasmid-encoded colistin resistance gene (mcr-1) has recently been reported in various Gram-negative species. However, the expression profile of mcr-1 remains unknown. Here, we investigated the expression of mcr-1 in various plasmids and bacteria. The mcr-1 expression levels in pMCR1_IncX4 varied from 1.81 × 10-5 to 1.05 × 10-4 (pmol per μg total RNA) in the two K. pneumoniae strains SZ03 and SZ04 (ST25) and the two E. coli strains SZ01 and CDA6 (ST2448 and ST167, respectively). The mcr-1 expression levels of pMCR1_IncI2 in E...
December 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/29285477/pseudomonas-aeruginosa-producing-metallo-%C3%AE-lactamases-vim-imp-sme-and-aim-in-the-clinical-isolates-of-intensive-care-units-a-university-hospital-in-isfahan-iran
#2
Farzin Khorvash, Mohammadreza Yazdani, Shiva Shabani, Aliasghar Soudi
Background: Pseudomonas aeruginosa is a severe challenge for antimicrobial therapy, due to the chromosomal mutations or exhibition of intrinsic resistance to various antimicrobial agents such as most β-lactams. We undertook this study to evaluate the existence of SME, IMP, AIM, and VIM metallo-β-lactamases (MBL) encoding genes among P. aeruginosa strains isolated from Intensive Care Unit (ICU) patients in Al-Zahra Hospital in Isfahan, Iran. Materials and Methods: In a retrospective cross-sectional study that was conducted between March 2012 and April 2013, a total of 48 strains of P...
2017: Advanced Biomedical Research
https://www.readbyqxmd.com/read/29272983/sub-inhibitory-concentration-of-essential-oils-induces-antibiotic-resistance-in-staphylococcus-aureus
#3
Barbara Turchi, Simone Mancini, Luisa Pistelli, Basma Najar, Filippo Fratini
Fourteen Staphylococcus aureus wild strains were stressed with sub-inhibitory concentration of five essential oils: Leptospermum scoparium (manuka), Origanum majorana (marjoram), Origanum vulgare (oregano), Satureja montana (winter savoury) and Thymus vulgaris (thyme). Antibiotics susceptibility profiles of the strains were determined by agar disk diffusion method before and after EOs treatment. The following antibiotics were employed: amoxicillin-clavulanic acid, amikacin, ampicillin, amoxicillin, aztreonam, ceftazidime, cephalothin, ciprofloxacin, colistin, cefotaxime, doxycycline, enrofloxacin, erythromycin, gentamicin, cephalexin, neomycin, piperacillin, rifampin, streptomycin, trimethoprim-sulphamethoxazole, tetracycline and tobramycin...
December 22, 2017: Natural Product Research
https://www.readbyqxmd.com/read/29225477/molecular-evaluation-of-colistin-resistant-gene-expression-changes-in-acinetobacter-baumannii-with-real-time-polymerase-chain-reaction
#4
Shahriar Sepahvand, Mohammad Ali Davarpanah, Amir Roudgari, Abbas Bahador, Vajihe Karbasizade, Zahra Kargar Jahromi
Background: Acinetobacter baumannii is an important human pathogen which has recently gained increased attention due to the occurrence of drug-resistant nosocomial infections in patients suffering from immune system disorders, and those in hospital intensive care units. The aim of this research was to identify and isolate A. baumannii strains resistant to colistin, determine antibiotic resistance pattern of this bacteria, investigate the presence of colistin-resistant genes, and finally assess the effect of expression changes in pmrA and pmrB genes resistant to A...
2017: Infection and Drug Resistance
https://www.readbyqxmd.com/read/29203405/inactivation-of-arn-operon-and-loss-of-aminoarabinose-on-lipopolysaccharide-as-the-cause-of-susceptibility-to-colistin-in-an-atypical-clinical-isolate-of-proteus-vulgaris
#5
Sophie Baron, Zineb Leulmi, Claude Villard, Abiola Olumuyiwa Olaitan, Amar A Telke, Jean-Marc Rolain
Colistin has become a last-line antibiotic for the treatment of multidrug resistant bacterial infections, but resistance to colistin has emerged in recent years. Some bacteria, such as Proteus sp. or Serratia sp., are intrinsically resistant to colistin but the exact mechanism of this resistance is not known. Here, we have identified the molecular support for the intrinsic colistin resistance in Proteus by comparative genomic transcriptomic and proteomic analysis of colistin susceptible (CSUR P1868_S) strain and a colistin resistant (CSUR P1867_R) strain of an atypical Proteus vulgaris...
December 1, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29176971/occurrence-of-extended-spectrum-%C3%AE-lactamases-kpc-type-and-mcr-1-2-producing-enterobacteriaceae-from-wells-river-water-and-wastewater-treatment-plants-in-oltrep%C3%A3-pavese-area-northern-italy
#6
Mariasofia Caltagirone, Elisabetta Nucleo, Melissa Spalla, Francesca Zara, Federica Novazzi, Vittoria M Marchetti, Aurora Piazza, Ibrahim Bitar, Marica De Cicco, Stefania Paolucci, Giorgio Pilla, Roberta Migliavacca, Laura Pagani
To evaluate the water compartment antibiotic-resistance contamination rates, 11 wells, five streams, and four treatment plants located in the Oltrepò Pavese area were screened for the presence of third generation cephalosporins resistant Gram-negative bacteria. Enterobacteriaceae were also characterized for the Extended-Spectrum-β-Lactamases (ESBLs), carbapenemases, and mcr-1 genes presence. From December 2014 to November 2015, 246 water samples were filtered, plated on Plate Count Agar, MacConkey Agar, and MacConkey Agar with cefotaxime...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29169321/lbjmr-medium-a-new-polyvalent-culture-medium-for-isolating-and-selecting-vancomycin-and-colistin-resistant-bacteria
#7
Lucie Bardet, Stéphanie Le Page, Thongpan Leangapichart, Jean-Marc Rolain
BACKGROUND: Multi-drug resistant bacteria are a phenomenon which is on the increase around the world, particularly with the emergence of colistin-resistant Enterobacteriaceae and vancomycin-resistant enterococci strains. The recent discovery of a plasmid-mediated colistin resistance with the description of the transferable mcr-1 gene raised concerns about the need for an efficient detection method for these pathogens, to isolate infected patients as early as possible. The LBJMR medium was developed to screen for all polymyxin-resistant Gram-negative bacteria, including mcr-1 positive isolates, and vancomycin-resistant Gram-positive bacteria...
November 23, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/29160808/interplay-between-colistin-resistance-virulence-and-fitness-in-acinetobacter-baumannii
#8
REVIEW
Gabriela Jorge Da Silva, Sara Domingues
Acinetobacter baumannii is an important opportunistic nosocomial pathogen often resistant to multiple antibiotics classes. Colistin, an "old" antibiotic, is now considered a last-line treatment option for extremely resistant isolates. In the meantime, resistance to colistin has been reported in clinical A. baumannii strains. Colistin is a cationic peptide that disrupts the outer membrane (OM) of Gram-negative bacteria. Colistin resistance is primarily due to post-translational modification or loss of the lipopolysaccharide (LPS) molecules inserted into the outer leaflet of the OM...
November 21, 2017: Antibiotics
https://www.readbyqxmd.com/read/29138303/cxc-chemokines-exhibit-bactericidal-activity-against-multidrug-resistant-gram-negative-pathogens
#9
Matthew A Crawford, Debra J Fisher, Lisa M Leung, Sara Lomonaco, Christine Lascols, Antonio Cannatelli, Tommaso Giani, Gian Maria Rossolini, Yohei Doi, David R Goodlett, Marc W Allard, Shashi K Sharma, Erum Khan, Robert K Ernst, Molly A Hughes
The continued rise and spread of antimicrobial resistance among bacterial pathogens pose a serious challenge to global health. Countering antimicrobial-resistant pathogens requires a multifaceted effort that includes the discovery of novel therapeutic approaches. Here, we establish the capacity of the human CXC chemokines CXCL9 and CXCL10 to kill multidrug-resistant Gram-negative bacteria, including New Delhi metallo-beta-lactamase-1-producing Klebsiella pneumoniae and colistin-resistant members of the family Enterobacteriaceae that harbor the mobile colistin resistance protein MCR-1 and thus possess phosphoethanolamine-modified lipid A...
November 14, 2017: MBio
https://www.readbyqxmd.com/read/29126221/identification-and-characterization-of-mcr-mediated-colistin-resistance-in-extraintestinal-escherichia-coli-from-poultry-and-livestock-in-china
#10
Afrah Kamal Yassin, Jilei Zhang, Jiawei Wang, Li Chen, Patrick Kelly, Patrick Butaye, Guangwu Lu, Jiansen Gong, Min Li, Lanjing Wei, Yaoyao Wang, Kezong Qi, Xiangan Han, Stuart Price, Terri Hathcock, Chengming Wang
Antimicrobial resistance to colistin has emerged worldwide threatening the efficacy of one of the last-resort antimicrobials used for the treatment of multidrug-resistant Enterobacteriaceae infection in humans. In this study, we investigated the presence of colistin resistance genes (mcr-1, mcr-2, mcr-3) in Escherichia coli strains isolated from poultry and livestock collected between 2004 and 2012 in China. Furthermore, we studied the maintenance and transfer of the mcr-1 gene in E. coli after serial passages...
November 8, 2017: FEMS Microbiology Letters
https://www.readbyqxmd.com/read/29117270/screening-for-the-presence-of-mcr-1-mcr-2-genes-in-shiga-toxin-producing-escherichia-coli-recovered-from-a-major-produce-production-region-in-california
#11
Daniela Mavrici, Jaszemyn C Yambao, Bertram G Lee, Beatriz Quiñones, Xiaohua He
The rapid spreading of polymyxin E (colistin) resistance among bacterial strains through the horizontally transmissible mcr-1 and mcr-2 plasmids has become a serious concern. The emergence of these genes in Shiga toxin-producing Escherichia coli (STEC), a group of human pathogenic bacteria was even more worrisome, urging us to investigate the prevalence of mcr genes among STEC isolates. A total of 1000 STEC isolates, recovered from livestock, wildlife, produce and other environmental sources in a major production region for leafy vegetables in California during 2006-2014, were screened by PCR for the presence of plasmid-borne mcr-1 and mcr-2...
2017: PloS One
https://www.readbyqxmd.com/read/29091215/soxrs-induces-colistin-hetero-resistance-in-enterobacter-asburiae-and-enterobacter-cloacae-by-regulating-the-acrab-tolc-efflux-pump
#12
Amar A Telke, Abiola Olumuyiwa Olaitan, Serge Morand, Jean-Marc Rolain
Background: Colistin is the last drug option for the treatment of MDR Gram-negative bacterial infections. Several types of resistance to colistin have been identified, including hetero-resistance, which has been observed in several Gram-negative pathogens. During a routine surveillance project on antimicrobial resistance, we found abnormal colistin-resistant Enterobacter asburiae and Enterobacter cloacae isolates. E. cloacae is an intestinal commensal bacterium and a well-known opportunistic nosocomial pathogen...
October 1, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29063811/emergence-of-colistin-resistance-in-enterobacter-aerogenes-from-croatia
#13
Branka Bedenić, Mirna Vranić-Ladavac, Carolina Venditti, Arjana Tambić-Andrašević, Nada Barišić, Marija Gužvinec, Natalie Karčić, Nicola Petrosillo, Ranko Ladavac, Antonino di Caro
A colistin-resistant Enterobacter aerogenes [study code 12264] was isolated from the tracheal aspirate of a 71-year-old male patient in the General Hospital [GH] in Pula, Croatia. The patient was previously treated in University Hospital Centre in Rijeka with colistin in order to eradicate Acinetobacter baumannii isolate, susceptible only to colistin and tigecycline. Genes encoding ESBLs [blaTEM, blaSHV, blaCTX-M, blaPER-1] were screened by PCR. The strain was shown to possess blaCTX-M-15 and blaTEM-1 genes...
October 24, 2017: Journal of Chemotherapy
https://www.readbyqxmd.com/read/29038441/distinct-mechanisms-of-acquisition-of-mcr-1-bearing-plasmid-by-salmonella-strains-recovered-from-animals-and-food-samples
#14
Mingquan Cui, Jinfei Zhang, Chunping Zhang, Ruichao Li, Edward Wai-Chi Chan, Chenbin Wu, Congming Wu, Sheng Chen
Since the report of its discovery in E. coli in late 2015, the plasmid-mediated colistin resistance gene, mcr-1, has been detected in various bacterial species in clinical setting and various environmental niches. However, the transmission mechanisms of this gene in Salmonella is less defined. In this study, we conducted a comprehensive study to characterize the genetic features of mcr-1-positive Salmonella strains isolated from animals and foods. Our data revealed that Salmonella recovered from animals and food specimens exhibited highly different PFGE patterns, and acquired mcr-1-encoding plasmids via different mechanism...
October 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29019312/widespread-distribution-of-mcr-1-bearing-bacteria-in-the-ecosystem-2015-to-2016
#15
Kaichao Chen, Edward Wai-Chi Chan, Miaomiao Xie, Liangwei Ye, Ning Dong, Sheng Chen
The recently discovered colistin resistance-encoding element, mcr-1, adds to the list of mobile resistance genes whose products rapidly erode the antimicrobial efficacy of not only the commonly used antibiotics, but also the last line agents of carbapenems and colistin. The relative prevalence of mcr-1-bearing strains in various ecological niches including 1,371 food samples, 480 animal faecal samples, 150 human faecal samples and 34 water samples was surveyed using a novel in-house method. Bacteria bearing mcr-1 were commonly detected in water (71% of samples), animal faeces (51%), food products (36%), and exhibited stable carriage in 28% of human subjects surveyed...
September 2017: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/28984232/chromagar-col-apse-a-selective-bacterial-culture-medium-for-the-isolation-and-differentiation-of-colistin-resistant-gram-negative-pathogens
#16
Muhd Haziq F Abdul Momin, David C Bean, Rene S Hendriksen, Marisa Haenni, Lynette M Phee, David W Wareham
PURPOSE: A selective chromogenic culture medium for the laboratory isolation and differentiation of colistin resistant Acinetobacter, Pseudomonas, Stenotrophomonas and Enterobacteriaceae spp. (CHROMagar COL-APSE) was developed, evaluated and compared to an existing selective bacterial culture medium (SuperPolymyxin). METHODOLOGY: The medium was challenged with 84 isolates, including polymyxin B (POL B)-susceptible and -resistant type strains and colistin (COL)-resistant organisms recovered from human and animal samples...
October 6, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28956539/appropriateness-of-antibiotic-prescription-for-targeted-therapy-of-infections-caused-by-multidrug-resistant-bacteria-assessment-of-the-most-common-improper-uses-in-a-tertiary-hospital-in-southern-italy
#17
Giulio Viceconte, Alberto Enrico Maraolo, Vita Dora Iula, Maria Rosaria Catania, Grazia Tosone, Raffaele Orlando
A huge proportion of antibiotic therapies for infections caused by multidrug-resistant bacteria (MDR) are inappropriate. In this study, we described the most common causes of inappropriateness of definitive antibiotic regimes in a large university hospital in southern Italy and we evaluated the impact on microbial eradication, length of stay, 30-day readmission and mortality. We retrospectively assessed 45 patients who received a definitive antibiotic therapy after isolation of multidrug-resistant Staphylococcus aureus, Enterococcus spp...
September 1, 2017: Le Infezioni in Medicina
https://www.readbyqxmd.com/read/28919044/susceptibility-of-colistin-resistant-pathogens-to-predatory-bacteria
#18
Sonal Dharani, Dong Hyun Kim, Robert M Q Shanks, Yohei Doi, Daniel E Kadouri
The increase in multidrug-resistant Gram-negative bacterial infections has forced the reintroduction of antibiotics such as colistin. However, the spread of the plasmid-borne mcr-1 colistin resistance gene have moved us closer to an era of untreatable Gram-negative infections. To evaluate whether predatory bacteria could be used as a potential therapeutic to treat this upcoming threat, the ability of Bdellovibrio bacteriovorus and Micavibrio aeruginosavorus to prey on several clinically relevant mcr-1-positive, colistin-resistant isolates was evaluated...
September 15, 2017: Research in Microbiology
https://www.readbyqxmd.com/read/28904677/-pulmonary-nocardiosis-in-immunocompetent-patients-about-2-cases
#19
Yasmina Rhofir, Rachida Zahraoui, Nabil Tiress, Hicham Naji-Amrani, Mouna Soualhi, Jamal Eddine Bourkadi
Nocardiosis is a rare but severe infection caused by bacteria of the genus nocardia, which belong to the order actinomycetales. If they can affect immunocompetent adult, nocardioses are pathologies affecting the individuals with weakened immune system. Pulmonary involvement is the most common manifestation, its correct management is based on diagnosis, which is often delayed due to non-specific symptoms and inconclusive specimens. We here report two cases of nocardiosis in immunocompetent patients. The first case concerns a 24-year old man with a history of smoking and alcoholism, hospitalized for chest pain and hemoptysis of low abundance evolving for two months, associated with the occurrence of dorsal subcutaneous fistulized abscess...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28878746/inhibition-of-new-delhi-metallo-%C3%AE-lactamase-1-ndm-1-producing-escherichia-coli-ir-6-by-selected-plant-extracts-and-their-synergistic-actions-with-antibiotics
#20
Brinda Chandar, Sundar Poovitha, Kaliappan Ilango, Ramasamy MohanKumar, Madasamy Parani
Improper use of antibiotics has led to a great concern in the development of pathogenic microbial resistance. New Delhi metallo-β-lactamase 1 (NDM-1) producing bacteria are resistant to most of the β-lactam antibiotics, and so far, no new compounds have been clinically tested against these bacteria. In this study, ethanol extracts from the leaves of 240 medicinal plant species were screened for antibacterial activity against an NDM-1 Escherichia coli strain. The extracts that showed antibacterial activity were then tested for minimum inhibitory concentrations (MICs) and zones of inhibition...
2017: Frontiers in Microbiology
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