keyword
https://read.qxmd.com/read/38528207/macrophage-re-programming-by-jak-inhibitors-relies-on-mafb
#21
JOURNAL ARTICLE
Baltasar López-Navarro, Miriam Simón-Fuentes, Israel Ríos, María Teresa Schiaffino, Alicia Sanchez, Mónica Torres-Torresano, Alicia Nieto-Valle, Isabel Castrejón, Amaya Puig-Kröger
Monocyte-derived macrophages play a key pathogenic role in inflammatory diseases. In the case of rheumatoid arthritis (RA), the presence of specific synovial tissue-infiltrating macrophage subsets is associated with either active disease or inflammation resolution. JAK inhibitors (JAKi) are the first targeted synthetic disease-modifying antirheumatic drugs (tsDMARD) approved for treatment of RA with comparable efficacy to biologics. However, the effects of JAKi on macrophage specification and differentiation are currently unknown...
March 25, 2024: Cellular and Molecular Life Sciences: CMLS
https://read.qxmd.com/read/38526615/ninety-day-postoperative-mortality-and-complications-in-continuous-and-unselected-single-stage-revisions-for-chronic-periprosthetic-joint-infection
#22
JOURNAL ARTICLE
Chenchen Yang, Baochao Ji, Guoqing Li, Xiaogang Zhang, Boyong Xu, Li Cao
PURPOSE: Single-stage revision has gained significant attention as a major surgical approach for periprosthetic joint infection (PJI). However, the 90-day mortality and complication profile of single-stage revision is poorly characterized. The purposes of this study were to determine the incidence rates of and identify the risk factors for 90-day postoperative mortality and complications of single-stage revision for chronic PJI. METHODS: A retrospective review was conducted on patients who underwent single-stage revision for PJI between August 2000 and May 2022...
March 25, 2024: International Orthopaedics
https://read.qxmd.com/read/38524267/can-we-achieve-pain-stratification-in-musculoskeletal-conditions-implications-for-clinical-practice
#23
REVIEW
Nidhi Sofat, Andrew Lambarth
In the last few years there has been an increased appreciation that pain perception in rheumatic and musculoskeletal diseases (RMDs) has several mechanisms which include nociceptive, inflammatory, nociplastic and neuropathic components. Studies in specific patient groups have also demonstrated that the pain experienced by people with specific diagnoses can present with distinctive components over time. For example, the pain observed in rheumatoid arthritis has been widely accepted to be caused by the activation of nociceptors, potentiated by the release of inflammatory mediators, including prostaglandins, leukotrienes and cytokine networks in the joint environment...
2024: Front Pain Res (Lausanne)
https://read.qxmd.com/read/38523940/an-unusual-case-of-non-typhoidal-salmonella-bacteremia-causing-life-threatening-aortitis
#24
Fawwad A Ansari, Stefan Gafoor, Mubashira Aftab, Zola Nlandu
Non-typhoidal Salmonella typically presents with gastroenteritis. However, an invasive Salmonella infection, which may be typically seen in immunocompromised patients, has a propensity for aortic involvement, especially in patients with risk factors for atherosclerosis. Here we present a 60-year-old female with multiple comorbid conditions and currently on immunosuppressants for rheumatoid arthritis, who presented with nausea, vomiting, and fever of three weeks duration and was found to have Salmonella bacteremia...
February 2024: Curēus
https://read.qxmd.com/read/38523896/a-rare-case-of-acute-methotrexate-toxicity-leading-to-bone-marrow-suppression
#25
Samreen Khuwaja, Matthew Lyons, Beenish Zulfiqar
Methotrexate is a first-line disease modifying antirheumatic drug used for the treatment of inflammatory arthritis. Bone marrow suppression is a common adverse reaction of methotrexate following its long-term use. However, low dose methotrexate is rarely associated with life-threatening bone marrow suppression. This case represents an atypical presentation of acute bone marrow suppression shortly after initiating treatment with low-dose methotrexate. A 76-year-old male patient presented with oral ulcers, poor oral intake, and acute kidney injury within 3 weeks of initiating 15 mg weekly of methotrexate for seronegative rheumatoid arthritis...
2024: Case Reports in Rheumatology
https://read.qxmd.com/read/38523584/evaluation-of-diagnostic-and-therapeutic-delay-in-patients-with-rheumatoid-arthritis-and-psoriatic-arthritis
#26
JOURNAL ARTICLE
M Iacovantuono, S Ferrigno, P Conigliaro, P Triggianese, A D'Antonio, F R Spinelli, A Bergamini, M S Chimenti
OBJECTIVE: A monocentric cross-sectional study recruiting rheumatoid arthritis (RA) and psoriatic arthritis (PsA) patients residing in the Lazio region, Italy, to assess factors related to diagnostic delay and treatment accessibility. METHODS: Clinical/serological data, including the time between symptom onset, diagnosis, and the beginning of treatment, were collected. Residence, referral to a rheumatologic center, physician who made the diagnosis, and previous misdiagnosis were also evaluated...
March 22, 2024: Reumatismo
https://read.qxmd.com/read/38522049/endothelial-dysfunction-and-risk-factors-for-atherosclerosis-in-psoriatic-arthritis-overview-and-comparison-with-rheumatoid-arthritis
#27
REVIEW
Konrad Kaleta, Julia Krupa, Wiktoria Suchy, Anna Sopel, Mariusz Korkosz, Jarosław Nowakowski
Endothelial dysfunction (ED) is defined as an impairment in the vasodilatory, anti-thrombotic, and anti-inflammatory properties of the cells that make up the lining of blood vessels. ED is considered a key step in the development of atherosclerotic cardiovascular disease. The association between ED and systemic inflammatory diseases is well established. However, the prevalence and clinical significance of ED in psoriatic arthritis (PsA) have been investigated to a lesser extent. This review aims to explore the link between ED and PsA, including ED in macro- and microcirculation, as well as risk factors for its occurrence in PsA and its relationship with atherosclerosis in PsA...
March 24, 2024: Rheumatology International
https://read.qxmd.com/read/38520228/environmental-risk-factors-protective-factors-and-biomarkers-for-hearing-loss-an-umbrella-review
#28
REVIEW
Xianpeng Xu, Yiru Liao, Lihong Zhang, Yu He, Ying Zhang, Dajing Xiong, Hui Xie
OBJECTIVE: We aimed to investigate the potential environmental risk factors, protective factors, and biomarkers of hearing loss (HL), and establish a hierarchy of evidence. DATA SOURCES: Embase, PubMed, Cochrane Library, and Web of Science electronic database from inception to June 1, 2023. REVIEW METHODS: We included meta-analyses of observational studies of associations between HL and environmental risk factors, protective factors, or biomarkers...
March 23, 2024: Otolaryngology—Head and Neck Surgery
https://read.qxmd.com/read/38519107/medication-utilisation-trends-during-pregnancy-and-factors-influencing-adverse-pregnancy-outcomes-in-patients-with-rheumatoid-arthritis
#29
JOURNAL ARTICLE
Yeo-Jin Song, Soo-Kyung Cho, Yu-Seon Jung, Sun-Young Jung, Jihyun Keum, Eunwoo Nam, Yoon-Kyoung Sung, Dae Hyun Yoo
OBJECTIVES: We aimed to investigate medication utilisation trends during pregnancy and identify factors associated with adverse pregnancy outcomes (APOs) in patients with rheumatoid arthritis (RA). METHODS: Female patients with RA aged 20-50 years were identified from the Korean national health insurance database between 2010 and 2020. Pregnancy episodes were divided into two groups according to pregnancy outcome: the delivery group and the APO group (abortion and stillbirth)...
March 22, 2024: RMD Open
https://read.qxmd.com/read/38518237/study-of-the-spread-of-medicinal-herbs-use-among-patients-suffering-from-chronic-diseases-in-iraq
#30
JOURNAL ARTICLE
Qayssar Joudah Fadheel, Rusul Ahmed Mohammed
OBJECTIVE: Aim: To assess the prevalence of medicinal plants, use among Iraqi patients with chronic disease and compare it with another study in same or different countries. PATIENTS AND METHODS: Materials and Methods: A randomized Internet and social media questionnaire was used. In this cross-sectional study, peoples with chronic diseases from different age group were recruited. Participants had an internet questionnaire to answer. This questionnaire embraced age, gender, occupation, marital status, education level and some lifestyle details as demographic data, a large proportion of the questionnaire was related to herbs, both prescribed and OTC ones...
2024: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://read.qxmd.com/read/38518214/risk-factors-for-lichen-sclerosus-a-case-control-study-of-43-000-finnish-women
#31
JOURNAL ARTICLE
Pia Halonen, Oskari Heikinheimo, Kishor Hadkhale, Mika Gissler, Eero Pukkala, Maija Jakobsson
OBJECTIVES: Lichen sclerosus (LS) is an inflammatory skin disease probably arising from an interplay of genetics, local irritation, and autoimmune processes. We identified potential risk factors for the disease using data from nationwide Finnish registries. METHODS: We identified all women diagnosed with LS within specialized health care during 1998-2016 (n = 10,692) and selected 3 age-matched population control women for each case. We calculated odds ratios (ORs) for possible risk factors using conditional logistic regression...
April 1, 2024: Journal of Lower Genital Tract Disease
https://read.qxmd.com/read/38517871/machine-learning-based-prediction-of-rheumatoid-arthritis-with-development-of-acpa-autoantibodies-in-the-presence-of-non-hla-genes-polymorphisms
#32
JOURNAL ARTICLE
Grzegorz Dudek, Sebastian Sakowski, Olga Brzezińska, Joanna Sarnik, Tomasz Budlewski, Grzegorz Dragan, Marta Poplawska, Tomasz Poplawski, Michał Bijak, Joanna Makowska
Machine learning (ML) algorithms can handle complex genomic data and identify predictive patterns that may not be apparent through traditional statistical methods. They become popular tools for medical applications including prediction, diagnosis or treatment of complex diseases like rheumatoid arthritis (RA). RA is an autoimmune disease in which genetic factors play a major role. Among the most important genetic factors predisposing to the development of this disease and serving as genetic markers are HLA-DRB and non-HLA genes single nucleotide polymorphisms (SNPs)...
2024: PloS One
https://read.qxmd.com/read/38516555/polymyalgia-rheumatica-post-sars-cov-2-infection
#33
Carolina Duarte-Salazar, José Eugenio Vazquez-Meraz, Lucio Ventura-Ríos, Cristina Hernández-Díaz, José Arellano-Galindo
There is growing evidence that infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can lead to dysregulation of the immune system and, consequently, the development of autoimmune phenomena. Here, we describe the case of a 75-year-old woman with rheumatic manifestations characterized by intense musculoskeletal pain and stiffness in the neck and shoulders, with sudden onset and with the inability to raise her arms. The patient was admitted with severe pain located in the neck and shoulders...
2024: Case Reports in Immunology
https://read.qxmd.com/read/38515982/advantages-of-chinese-herbal-medicine-in-treating-rheumatoid-arthritis-a-focus-on-its-anti-inflammatory-and-anti-oxidative-effects
#34
REVIEW
Xiaoyu Wang, Youqian Kong, Zeguang Li
Oxidative stress is a condition characterized by an imbalance between the oxidative and antioxidant processes within the human body. Rheumatoid arthritis (RA) is significantly influenced by the presence of oxidative stress, which acts as a pivotal factor in its pathogenesis. Elevated levels of mitochondrial reactive oxygen species (ROS) and inflammation have been found to be closely associated in the plasma of patients with RA. The clinical treatment strategies for this disease are mainly chemical drugs, such as nonsteroidal anti-inflammatory drugs (NSAIDs), disease-modifying anti-rheumatic drugs (DMARDs), glucocorticoids (GCs) and biological agents, but it is difficult for patients to accept long-term drug treatment and its side effects...
2024: Frontiers in Medicine
https://read.qxmd.com/read/38515381/innovate-therapeutic-targets-for-autoimmune-diseases-insights-from-proteome-wide-mendelian-randomization-and-bayesian-colocalization
#35
JOURNAL ARTICLE
Qiubai Jin, Feihong Ren, Ping Song
BACKGROUND: Despite growing knowledge regarding the pathogenesis of autoimmune diseases (ADs) onset, the current treatment remains unsatisfactory. This study aimed to identify innovative therapeutic targets for ADs through various analytical approaches. RESEARCH DESIGN AND METHODS: Utilizing Mendelian randomization, Bayesian co-localization, phenotype scanning, and protein-protein interaction network, we explored potential therapeutic targets for 14 ADs and externally validated our preliminary findings...
December 2024: Autoimmunity
https://read.qxmd.com/read/38514918/prognosis-and-prognostic-factors-of-lung-cancer-complications-in-patients-with-rheumatoid-arthritis
#36
JOURNAL ARTICLE
Shunichi Fujita, Kazuhisa Nakano, Akiko Nagasu, Sumie Hiramatsu-Asano, Takahiko Akagi, Yoshitaka Morita
AIM: To clarify the prognosis and prognostic factors for lung cancer in patients with rheumatoid arthritis (RA). METHODS: In this retrospective longitudinal study, we investigated the medical records of patients with RA among 1422 patients diagnosed with lung cancer and registered in a hospital-based cancer registry between January 2013 and May 2022. The Kaplan-Meier method and Cox proportional hazards model were used to analyze survival and identify predictive factors...
March 2024: International Journal of Rheumatic Diseases
https://read.qxmd.com/read/38514707/association-of-hla-drb1-locus-with-treatment-response-to-abatacept-or-tnf-inhibitors-in-patients-with-seropositive-rheumatoid-arthritis
#37
JOURNAL ARTICLE
Soojin Cha, So-Young Bang, Young Bin Joo, Soo-Kyung Cho, Chan-Bum Choi, Yoon-Kyoung Sung, Tae-Hwan Kim, Jae-Bum Jun, Dae Hyun Yoo, Hye-Soon Lee, Sang-Cheol Bae
The strongest genetic risk factor for rheumatoid arthritis (RA) has been known as HLA-DRB1 based on amino acid positions 11, 71, and 74. This study analyzed the association between specific HLA-DRB1 locus and treatment response to abatacept or TNF inhibitors (TNFi) in patients with seropositive RA. A total of 374 Korean RA patients were treated with abatacept (n = 110) or TNFi (n = 264). Associations between HLA-DRB1 and treatment response after 6 months were analyzed using multivariable logistic regression...
March 21, 2024: Scientific Reports
https://read.qxmd.com/read/38514448/predicting-risk-of-subsequent-pregnancy-loss-among-women-with-recurrent-pregnancy-loss-an-immunological-factor-based-multivariable-model
#38
JOURNAL ARTICLE
Fangxiang Mu, Mei Wang, Xianghui Zeng, Fang Wang
PROBLEM: Studies on subsequent pregnancy loss prediction models specific for recurrent pregnancy loss (RPL) patients are very limited. This study aims to develop a risk predictive model based on the immunological parameters for the subsequent pregnancy loss risk in northwest Chinese RPL patients. METHOD OF STUDY: Totally of 357 RPL patients recruited from Lanzhou University Second Hospital were included in this retrospective study. Univariate analysis was performed on RPL patients with outcomes of live birth or pregnancy loss...
March 2024: American Journal of Reproductive Immunology: AJRI
https://read.qxmd.com/read/38510702/causal-relationship-between-pcsk9-inhibitor-and-primary-glomerular-disease-a-drug-target-mendelian-randomization-study
#39
JOURNAL ARTICLE
Hangyu Duan, Yue Shi, Qi Zhang, Xiujie Shi, Yifan Zhang, Jing Liu, Yu Zhang
BACKGROUND: Successive observational studies have highlighted low-density lipoprotein cholesterol (LDL-C) as a standalone risk factor for the progression of chronic kidney disease (CKD) to end-stage renal disease. Lowering LDL-C levels significantly reduces the incidence of atherosclerotic events in patients with progressive CKD. Recent research indicates that proprotein convertase subtilisin kexin 9 (PCSK9) inhibitors not only effectively lower LDL-C levels in CKD patients but also exhibit therapeutic potential for autoimmune diseases such as systemic lupus erythematosus, rheumatoid arthritis, and ulcerative colitis...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38510457/the-protective-effect-of-tumor-necrosis-factor-alpha-inhibitors-in-covid-19-in-patients-with-inflammatory-rheumatic-diseases-compared-to-the-general-population-a-comparison-of-two-german-registries
#40
JOURNAL ARTICLE
Rebecca Hasseli, Frank Hanses, Melanie Stecher, Christof Specker, Tobias Weise, Stefan Borgmann, Martina Hasselberger, Bernd Hertenstein, Martin Hower, Bimba F Hoyer, Carolin Koll, Andreas Krause, Marie von Lilienfeld-Toal, Hanns-Martin Lorenz, Uta Merle, Susana M Nunes de Miranda, Mathias W Pletz, Anne C Regierer, Jutta G Richter, Siegbert Rieg, Christoph Roemmele, Maria M Ruethrich, Tim Schmeiser, Hendrik Schulze-Koops, Anja Strangfeld, Maria J G T Vehreschild, Florian Voit, Reinhard E Voll, Jörg Janne Vehreschild, Ulf Müller-Ladner, Alexander Pfeil
OBJECTIVES: To investigate, whether inflammatory rheumatic diseases (IRD) inpatients are at higher risk to develop a severe course of SARS-CoV-2 infections compared to the general population, data from the German COVID-19 registry for IRD patients and data from the Lean European Survey on SARS-CoV-2 (LEOSS) infected patients covering inpatients from the general population with SARS-CoV-2 infections were compared. METHODS: 4310 (LEOSS registry) and 1139 cases (IRD registry) were collected in general...
2024: Frontiers in Medicine
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