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Lymphangiogenesis

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https://www.readbyqxmd.com/read/29676352/comparison-of-lymphangiogenesis-lymphatic-invasion-and-axillary-lymph-node-metastasis-in-breast-carcinoma
#1
Prerna Guleria, V Srinivas, D Basannar, Vibha Dutta
Context: Lymphangiogenesis correlates with poor prognosis in Invasive Ductal Carcinoma (IDC) breast. D2-40 antibody, a specific marker for lymphatic endothelium, differentiates lymphatic from vascular endothelium. Therefore, the aims of this study were to estimate lymphangiogenesis using D2-40 antibody and correlate with lymphatic invasion (LI) and axillary lymph node (LN) status and compare lymphatic mean vessel density (LMVD) with Tumor (T) and Node (N) stages and grade of tumor. Methods and Material: The study was conducted on fifty consecutive cases of IDC breast who underwent modified radical mastectomy (MRM) from Jan 2009 to March 2011...
April 2018: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/29666442/matrix-stiffness-controls-lymphatic-vessel-formation-through-regulation-of-a-gata2-dependent-transcriptional-program
#2
Maike Frye, Andrea Taddei, Cathrin Dierkes, Ines Martinez-Corral, Matthew Fielden, Henrik Ortsäter, Jan Kazenwadel, Dinis P Calado, Pia Ostergaard, Marjo Salminen, Liqun He, Natasha L Harvey, Friedemann Kiefer, Taija Mäkinen
Tissue and vessel wall stiffening alters endothelial cell properties and contributes to vascular dysfunction. However, whether extracellular matrix (ECM) stiffness impacts vascular development is not known. Here we show that matrix stiffness controls lymphatic vascular morphogenesis. Atomic force microscopy measurements in mouse embryos reveal that venous lymphatic endothelial cell (LEC) progenitors experience a decrease in substrate stiffness upon migration out of the cardinal vein, which induces a GATA2-dependent transcriptional program required to form the first lymphatic vessels...
April 17, 2018: Nature Communications
https://www.readbyqxmd.com/read/29661142/neutrophils-in-primary-gastric-tumors-are-correlated-with-neutrophil-infiltration-in-tumor-draining-lymph-nodes-and-the-systemic-inflammatory-response
#3
Soichiro Hiramatsu, Hiroaki Tanaka, Junya Nishimura, Chie Sakimura, Tatsuro Tamura, Takahiro Toyokawa, Kazuya Muguruma, Masakazu Yashiro, Kosei Hirakawa, Masaichi Ohira
BACKGROUND: Tumor-Associated Neutrophils (TANs) may be able to induce lymphangiogenesis and angiogenesis, although the detailed roles of TANs remain unclear. The Neutrophil-Lymphocyte Ratio (NLR) is an inflammation-based prognostic factor for gastric cancer. This study aimed to investigate the distribution of CD15+ neutrophils in the primary tumor and Tumor-Draining Lymph Nodes (TDLNs), and to examine the association of TANs with the clinicopathological features (including NLR) of patients with gastric cancer...
April 16, 2018: BMC Immunology
https://www.readbyqxmd.com/read/29655846/telocyte-like-cells-containing-weibel-palade-bodies-in-rat-lamina-fusca
#4
C E Petrea, M C Rusu, V S Mănoiu, A D Vrapciu
Telocytes (TCs) are cells with long, thin and moniliform processes called telopodes. These cells have been found in numerous tissues, including the eye choroid and sclera. Lamina fusca (LF), an anatomical structure located at the sclera-choroid junction, has outer fibroblastic lamellae containing cells with long telopodes. The purpose of this study was to evaluate, via transmission electron microscopy, the LF for the presence of endothelial-specific ultrastructural features, such as Weibel-Palade bodies (WPBs), in the residing TCs...
April 12, 2018: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/29650694/lymphatic-vasculature-requires-er-estrogen-receptor-%C3%AE-signaling-to-protect-from-lymphedema
#5
Florent Morfoisse, Florence Tatin, Benoit Chapût, Nicole Therville, Charlotte Vaysse, Raphael Métivier, Julie Malloizel-Delaunay, Francoise Pujol, Anne-Claire Godet, Fabienne De Toni, Frederic Boudou, Katia Grenier, David Dubuc, Eric Lacazette, Anne-Catherine Prats, Julie Guillermet-Guibert, Francoise Lenfant, Barbara Garmy-Susini
OBJECTIVE: Estrogens exert beneficial effect on the blood vascular system. However, their role on the lymphatic system has been poorly investigated. We studied the protective effect of the 17β estradiol-the most potent endogenous estrogen-in lymphedema-a lymphatic dysfunction, which results in a massive fluid and fat accumulation in the limb. APPROACH AND RESULTS: Screening of DNA motifs able to mobilize ERs (estrogen receptors) and quantitative real-time polymerase chain reaction analysis revealed that estradiol promotes transcriptional activation of lymphangiogenesis-related gene expression including VEGF (vascular endothelial growth factor)-D, VEGFR (VEGF receptor)-3, lyve-1, and HASs (hyaluronan synthases)...
April 12, 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29649427/vegfr-3-signaling-is-regulated-by-a-g-protein-activator-activator-of-g-protein-signaling-8-in-lymphatic-endothelial-cells
#6
Miho Sakima, Hisaki Hayashi, Abdullah Al Mamun, Motohiko Sato
Vascular endothelial growth factor C (VEGFC) and its cognate receptor VEGFR-3 play a key role in lymphangiogenesis. We previously reported that an ischemia-inducible Gβγ signal regulator, activator of G-protein signaling 8 (AGS8), regulated the subcellular distribution of vascular endothelial growth factor receptor-2 (VEGFR-2) and influenced VEGFA-induced signaling in vascular endothelial cells. Here, we report that AGS8 regulates VEGFR-3, which is another subtype of the VEGF receptor family, and mediates VEGFC signaling in human dermal lymphatic endothelial cells (HDLECs)...
April 9, 2018: Experimental Cell Research
https://www.readbyqxmd.com/read/29629844/aspirin-suppresses-components-of-lymphangiogenesis-and-lymphatic-vessel-remodeling-by-inhibiting-the-nf-%C3%AE%C2%BAb-vcam-1-pathway-in-human-lymphatic-endothelial-cells
#7
Orawin Prangsaengtong, Phatcharida Jantaree, Kriengsak Lirdprapamongkol, Lukana Ngiwsara, Jisnuson Svasti, Keiichi Koizumi
Lymphangiogenesis is the process of new vessel formation from pre-existing lymphatic vessels. The process mainly involves cell adhesion, migration, and tubule formation of lymphatic endothelial cells. Tumor-induced lymphangiogenesis is an important factor contributing to promotion of tumor growth and cancer metastasis via the lymphatic system. Finding the non-toxic agents that can prevent or inhibit lymphangiogenesis may lead to blocking of lymphatic metastasis. Recently, aspirin, a non-steroidal anti-inflammatory drug (NSAID), has been reported to inhibit in vivo lymphangiogenesis in tumor and incision wound models, but the mechanisms of actions of aspirin on anti-lymphangiogenesis have been less explored...
April 1, 2018: Vascular Medicine
https://www.readbyqxmd.com/read/29629370/effect-of-co-presentation-of-adhesive-ligands-and-short-hyaluronan-on-lymphendothelial-cells
#8
Christiane H Antoni, Yvonne McDuffie, Jochen Bauer, Jonathan P Sleeman, Heike Boehm
Controlled activation of lymphangiogenesis through functional biomaterials represents a promising approach to support wound healing after surgical procedures, yet remains a challenge. In a synthetic biological approach, we therefore set out to mimic the basal microenvironment of human primary dermal lymphatic endothelial cells (LECs) during lymphangiogenesis. As the extracellular matrix component hyaluronan (HA) regulates lymphangiogenesis, we designed a bifunctional surface in which adhesive peptide ligands and short HA oligosaccharides (sHA) tethered to nanoparticles are copresented to the basal side of LECs in a controlled, concentration-dependent manner...
2018: Frontiers in Bioengineering and Biotechnology
https://www.readbyqxmd.com/read/29615616/heterogeneity-in-vegfr3-levels-drives-lymphatic-vessel-hyperplasia-through-cell-autonomous-and-non-cell-autonomous-mechanisms
#9
Yan Zhang, Maria H Ulvmar, Lukas Stanczuk, Ines Martinez-Corral, Maike Frye, Kari Alitalo, Taija Mäkinen
Incomplete delivery to the target cells is an obstacle for successful gene therapy approaches. Here we show unexpected effects of incomplete targeting, by demonstrating how heterogeneous inhibition of a growth promoting signaling pathway promotes tissue hyperplasia. We studied the function of the lymphangiogenic VEGFR3 receptor during embryonic and post-natal development. Inducible genetic deletion of Vegfr3 in lymphatic endothelial cells (LECs) leads to selection of non-targeted VEGFR3+ cells at vessel tips, indicating an indispensable cell-autonomous function in migrating tip cells...
April 3, 2018: Nature Communications
https://www.readbyqxmd.com/read/29610929/comp-angiopoietin-1-ameliorates-inflammation-induced-lymphangiogenesis-in-dextran-sulfate-sodium-dss-induced-colitis-model
#10
Ae Sin Lee, Mi Jeong Sung, Won Kim, Yu Jin Jung
Alterations in the intestinal lymphatic network are pathological processes as related to inflammatory bowel disease (IBD). In this study, we demonstrated that reduction in inflammation-induced lymphangiogenesis ameliorates experimental acute colitis. A soluble and stable angiopoietin-1 (Ang1) variant, COMP-Ang1, possesses anti-inflammatory and angiogenic effects. We investigated the effects of COMP-Ang1 on an experimental colonic inflammation model. Experimental colitis was induced in mice by administering 3% dextran sulfate sodium (DSS) via drinking water...
April 2, 2018: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://www.readbyqxmd.com/read/29607940/involvement-of-tumor-lymphatic-system-in-translocation-of-intratumorally-injected-liposomes
#11
Kosuke Shimizu, Satomi Yamaguchi Ikeuchi, Ai Okajima, Genki Nakamura, Eiichi Muraoka, Naoto Oku
The tumor microenvironment is one of the key factors contributing to the efficiency of drug delivery to a tumor. It has been reported that lymphangiogenesis is induced in certain tumors. Because the lymphatic system functions as a drainage one, it is possible that tumor lymphatic vessels alter not only the tumor microenvironment, but also the distribution of drug nanocarriers accumulated in the tumor tissue. Herein, we aimed to elucidate the involvement of the tumor lymphatic system in the translocation of intratumoral liposomes to regional lymph nodes by using vascular endothelial growth factor (VEGF)-C-overexpressing B16F10 tumor-bearing mice (B16/VEGF-C)...
2018: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29605736/multiple-roles-of-lymphatic-vessels-in-tumor-progression
#12
REVIEW
Qiaoli Ma, Lothar C Dieterich, Michael Detmar
Sentinel lymph node metastasis is a prognostic indicator for systemic tumor spread in many types of cancers, and tumor lymphangiogenesis correlates with reduced survival. Consequently, lymphatic vessels have been suggested to promote tumor progression in multiple ways. Tumor lymphangiogenesis occurs both in primary tumors and at distant (pre-) metastatic sites, and facilitates lymphatic invasion and tumor cell dissemination. Lymphatic vessels have also emerged as regulators of tumor immunity, transporting tumor antigens to lymph nodes and directly interacting with immune cells...
March 29, 2018: Current Opinion in Immunology
https://www.readbyqxmd.com/read/29601983/corneal-lymphangiogenesis-facilitates-ocular-surface-inflammation-and-cell-trafficking-in-dry-eye-disease
#13
Yong Woo Ji, Jae Lim Lee, Hyun Goo Kang, Nayeong Gu, Haewon Byun, Areum Yeo, Hyemi Noh, Soyoung Kim, Eun Young Choi, Jong Suk Song, Hyung Keun Lee
PURPOSE: While the normal cornea has limited innervation by the lymphatic system, chronic immune-inflammatory disorders such as dry eye (DE) can induce lymphangiogenesis in the ocular surface. Using a conditional knock-down murine model, Lyve-1Cre ;VEGFR2flox mice, this study investigated the role of lymphangiogenesis in the pathophysiology of DE. METHODS: DE was induced in both wild type (WT) B6 and Lyve-1Cre ;VEGFR2flox mice. Tissue immunostaining and volumetric gross measurements were used to assess changes in the ocular surface, skin, and lymph nodes (LNs)...
March 27, 2018: Ocular Surface
https://www.readbyqxmd.com/read/29599774/chemokine-ccl4-induces-vascular-endothelial-growth-factor-c-expression-and-lymphangiogenesis-by-mir-195-3p-in-oral-squamous-cell-carcinoma
#14
Ming-Yu Lien, Hsiao-Chi Tsai, An-Chen Chang, Ming-Hsui Tsai, Chun-Hung Hua, Shih-Wei Wang, Chih-Hsin Tang
The inflammatory chemokine (C-C motif) ligand 4 (CCL4) plays an important role in the pathogenesis and progression of cancer. In particular, higher serum CCL4 levels in patients with oral squamous cell carcinoma (OSCC) are associated with a more advanced stage of disease. OSCC accounts for approximately 95% of oral cancer in Taiwan and has a poor prognosis, due to aggressive local invasion and metastasis, leading to recurrence. OSCC spreads preferentially through lymphatic vessels and has the propensity to metastasize to the cervical lymph nodes even in the early stage of disease...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29596308/ep4-as-a-therapeutic-target-for-aggressive-human-breast-cancer
#15
REVIEW
Mousumi Majumder, Pinki Nandi, Ahmed Omar, Kingsley Chukwunonso Ugwuagbo, Peeyush K Lala
G-protein-coupled receptors (GPCRs, also called seven-transmembrane or heptahelical receptors) are a superfamily of cell surface receptor proteins that bind to many extracellular ligands and transmit signals to an intracellular guanine nucleotide-binding protein (G-protein). When a ligand binds, the receptor activates the attached G-protein by causing the exchange of Guanosine-5'-triphosphate (GTP) for guanosine diphosphate (GDP). They play a major role in many physiological functions, as well as in the pathology of many diseases, including cancer progression and metastasis...
March 29, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29593061/biomarkers-of-chondrosarcoma
#16
REVIEW
Wonju Jeong, Ha-Jeong Kim
Clinical outcome prediction is major concern to patients with cancer. Various molecular markers in various carcinomas have been identified in the past few decades. However, accurate predictors in chondrosarcoma have not been developed, even though chondrosarcoma is the second most common primary bone tumour. Chondrosarcoma is the cartilage-forming malignancy and shows a wide spectrum of clinicopathological behaviours. The majority of chondrosarcoma grows slowly and rarely metastasises, and adequate surgery leads to a good prognosis...
March 28, 2018: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29569868/what-happens-to-an-acellular-dermal-matrix-after-implantation-in-the-human-body-a-histological-and-electron-microscopic-study
#17
Martin Boháč, Ľuboš Danišovič, Ján Koller, Jana Dragúňová, Ivan Varga
Acellular matrices are used for various purposes and they have been studied extensively for their potential roles in regenerating tissues or organs. The acellular matrix generates physiological cues that mimic the native tissue microenvironment. Acellular dermal matrix (ADM) is a soft connective tissue graft generated by a decellularization process that preserves the intact extracellular skin matrix. Upon implantation, this structure serves as a scaffold for donor-side cells to facilitate subsequent incorporation and revascularization...
January 22, 2018: European Journal of Histochemistry: EJH
https://www.readbyqxmd.com/read/29550286/orthotopic-transfer-of-vascularized-groin-lymph-node-flap-in-the-treatment-of-breast-cancer-related-lymphedema-clinical-results-lymphoscintigraphy-findings-and-proposed-mechanism
#18
Hin-Lun Liu, Suet-Ying Pang, Chung-Ching Lee, Melody Man-Kuen Wong, Hon-Ping Chung, Yu-Wai Chan
INTRODUCTION: Vascularized lymph node transfer (VLNT) has become very popular in the treatment of secondary lymphedema. However, the mechanism has not been clearly elucidated. The purpose of this study was (1) to evaluate the outcome of vascularized groin lymph node (VGLN) transfer using axilla as a recipient site in patients with breast cancer-related lymphedema (BCRL) and (2) to provide radiological evidence of lymphangiogenesis in VLNT. METHODS: Between August 2013 and June 2016, 30 consecutive patients with a mean age of 60 years underwent VGLN transfer for BCRL...
February 28, 2018: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/29547756/silencing-of-discoidin-domain-receptor-1-ddr1-concurrently-inhibits-multiple-steps-of-metastasis-cascade-in-gastric-cancer
#19
Ryo Yuge, Yasuhiko Kitadai, Hidehiko Takigawa, Toshikatsu Naito, Naohide Oue, Wataru Yasui, Shinji Tanaka, Kazuaki Chayama
Accumulating evidence suggests that a unique set of receptor tyrosine kinases, known as discoidin domain receptors (DDRs), plays a role in cancer progression by interacting with the surrounding collagen matrix. In this study, we investigated the expression and role of DDR1 in human gastric cancer metastasis. Proliferation, migration, invasion, and tube formation assays were conducted in DDR1-expressing MKN74 gastric cancer cells and corresponding DDR1-silenced cells. The effects of DDR1 on tumor growth and metastasis were examined in orthotopically implanted and experimental liver metastasis models in nude mice...
March 13, 2018: Translational Oncology
https://www.readbyqxmd.com/read/29544697/the-expression-of-p-mtor-and-coup-tfii-correlates-with-increased-lymphangiogenesis-and-lymph-node-metastasis-in-prostate-adenocarcinoma
#20
Ioannis Lilis, Ioanna Giopanou, Helen Papadaki, Kostis Gyftopoulos
BACKGROUND: Mammalian target of rapamycin (mTOR) is a central regulator of major cellular processes such as growth and proliferation. Deregulated mTOR signaling is implicated in a wide spectrum of human malignancies including prostate cancer. The aim of this study is to address the role of phosphorylated mTOR (p-mTOR) in prostate adenocarcinoma-induced lymphangiogenesis and lymph node metastasis as well as to investigate its relationship with chicken ovalbumin upstream promoter transcriptional factor 2 (COUP-TFII) and the vascular endothelial growth factors A/C (VEGF A/C)...
March 12, 2018: Urologic Oncology
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