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Lymphangiogenesis

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https://www.readbyqxmd.com/read/28636415/comprehensive-modeling-of-corneal-alkali-injury-in-the-rat-eye
#1
Hosoon Choi, Casie Phillips, Joo Youn Oh, Eileen M Stock, Dong-Ki Kim, Jae-Kyung Won, Samuel Fulcher
PURPOSE: To characterize the molecular, clinical, and histopathological profiles in the rat cornea after alkali injury over a 21-day period. METHODS: Alkali injury was induced in one eye of male Lewis rats. Corneal opacity and corneal neovascularization were assessed daily. Real-time qRT-PCR analysis and immunohistochemical staining were conducted to examine inflammation, neovascularization, and fibrosis. RESULTS: We found that within 2 hours of chemical exposure, corneal opacification rapidly developed with an acute increase in various cytokine expressions, while several cytokines demonstrated a secondary peak by day 7...
June 21, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28629427/targeting-vegfr-3-2-signaling-pathways-with-ad0157-a-potential-strategy-against-tumor-associated-lymphangiogenesis-and-lymphatic-metastases
#2
Melissa García-Caballero, Jenny Paupert, Silvia Blacher, Maureen Van de Velde, Ana Rodríguez Quesada, Miguel Angel Medina, Agnès Noël
BACKGROUND: Lymphatic metastasis is one of the leading causes of death in patients with different types of cancer and is the main prognostic factor for the disease survival. The formation of new lymphatic vessels (lymphangiogenesis) in primary tumors facilitates tumor cell dissemination to regional lymph nodes and correlates with distant metastases. Lymphangiogenesis has thus emerged as a suitable therapeutic target to block metastases, but no anti-lymphangiogenic compounds have been approved for clinical use to date...
June 19, 2017: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/28627412/macrophages-regulate-unilateral-ureteral-obstruction-induced-renal-lymphangiogenesis-through-c-c-motif-chemokine-receptor-2-dependent-phosphatidylinositol-3-kinase-akt-mechanistic-target-of%C3%A2-rapamycin-signaling-and-hypoxia-inducible-factor-1%C3%AE-vascular-endothelial
#3
Yan-Chao Guo, Meng Zhang, Fa-Xi Wang, Guang-Chang Pei, Fei Sun, Ying Zhang, Xiaoyu He, Yi Wang, Jia Song, Feng-Ming Zhu, Nuruliarizki S Pandupuspitasari, Jing Liu, Kun Huang, Ping Yang, Fei Xiong, Shu Zhang, Qilin Yu, Ying Yao, Cong-Yi Wang
Lymphangiogenesis occurs during renal fibrosis in patients with chronic kidney diseases and vascular endothelial growth factor (VEGF)-C is required for the formation of lymphatic vessels; however, the underlying mechanisms remain unclear. We demonstrate that macrophages can regulate unilateral ureteral obstruction (UUO)-induced renal lymphangiogenesis by expressing high levels of VEGF-C by C-C motif chemokine receptor 2 (CCR2)-mediated signaling. Mice deficient in Ccr2 manifested repressed lymphangiogenesis along with attenuated renal injury and fibrosis after UUO induction...
June 13, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/28623914/synaptonemal-complex-protein-3-is-associated-with-lymphangiogenesis-in-non-small-cell-lung-cancer-patients-with-lymph-node-metastasis
#4
Haruhisa Kitano, Joon-Yong Chung, Kyung Hee Noh, Young-Ho Lee, Tae Woo Kim, Seok Hyung Lee, Soo-Heang Eo, Hyung Jun Cho, Chel Hun Choi, Shuhei Inoue, Jun Hanaoka, Junya Fukuoka, Stephen M Hewitt
BACKGROUND: The interaction of vascular endothelial growth factor-C (VEGF-C)/VEGF-D/VEGF receptor-3 is considered to be a major driver of lymphangiogenesis, however the mechanism of this process remains unclear. We aimed to investigate the possible lymphangiogenic significance of synaptonemal complex protein 3 (SCP3) in non-small cell lung cancer (NSCLC). METHODS: The expression of SCP3, VEGF-C, and VEGF-D were measured and examined a correlation between SCP3 and VEGF-C or VEGF-D in various human lung cancer cell lines...
June 17, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/28614788/apelin-modulates-pathological-remodeling-of-lymphatic-endothelium-after-myocardial-infarction
#5
Florence Tatin, Edith Renaud-Gabardos, Anne-Claire Godet, Fransky Hantelys, Francoise Pujol, Florent Morfoisse, Denis Calise, Fanny Viars, Philippe Valet, Bernard Masri, Anne-Catherine Prats, Barbara Garmy-Susini
Lymphatic endothelium serves as a barrier to control fluid balance and immune cell trafficking to maintain tissue homeostasis. Long-term alteration of lymphatic vasculature promotes edema and fibrosis, which is an aggravating factor in the onset of cardiovascular diseases such as myocardial infarction. Apelin is a bioactive peptide that plays a central role in angiogenesis and cardiac contractility. Despite an established role of apelin in lymphangiogenesis, little is known about its function in the cardiac lymphatic endothelium...
June 15, 2017: JCI Insight
https://www.readbyqxmd.com/read/28611026/map4k4-impairs-energy-metabolism-in-endothelial-cells-and-promotes-insulin-resistance-in-obesity
#6
Rachel J Roth Flach, Marina T DiStefano, Laura V Danai, Ozlem Senol-Cosar, Joseph C Yawe, Mark Kelly, Lorena Garcia Menendez, Michael P Czech
The blood vasculature responds to insulin, influencing hemodynamic changes in the periphery, which promotes tissue nutrient and oxygen delivery and thus metabolic function. The lymphatic vasculature regulates fluid and lipid homeostasis, and impaired lymphatic function can contribute to atherosclerosis and obesity. Recent studies have suggested a role for endothelial cell (EC) Mitogen activated protein kinase kinase kinase kinase 4 (Map4k4) in developmental angiogenesis and lymphangiogenesis as well as atherosclerosis...
June 13, 2017: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28607595/e2f8-is-a-potential-therapeutic-target-for-hepatocellular-carcinoma
#7
REVIEW
Yi Lv, Jia Xiao, Jing Liu, Feiyue Xing
E2F transcriptional factors are widely expressed in a number of tissues and organs, possessing many regulatory functions related to cellular proliferation, differentiation, DNA repair, cell-cycle and cell apoptosis. E2F8 is a recently identified member of the E2F family with a duplicated DNA-binding domain feature discriminated from E2F1-6, controlling gene expression in a dimerization partner-independent manner. It is indispensable for angiogenesis, lymphangiogenesis and embryonic development. Although E2F8 and E2F7 perform complementary and overlapping functions in many cell metabolisms, E2F8, but not E2F7, overexpresses remarkably in hepatocellular carcinoma (HCC) to facilitate the HCC occurrence and development via activating a E2F1/ Cyclin D1 signaling pathway to regulate the G1- to S-phase transition of cell cycle progression or transcriptionally suppressing CDK1 to induce hepatocyte polyploidization...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28602571/cytoplasmic-neuropilin-2-is-associated-with-metastasis-and-a-poor-prognosis-in-early-tongue-cancer-patients
#8
H S Ong, S Gokavarapu, Q Xu, Z Tian, J Li, T Ji, C P Zhang
Neuropilin 2 (Nrp2) plays an important role in regulating lymphangiogenesis. Nrp2 expression in early tongue cancer was investigated to predict lymph node metastasis and the long-term prognosis. The relationships between clinicopathological variables of cT1-T2N0 tongue squamous cell carcinoma (SCC) and overexpression of Nrp2, vascular endothelial growth factor C (VEGFC), vascular endothelial growth factor receptor 3 (VEGFR3), and semaphorin 3F (Sema3F) were analyzed. Expression levels were compared using oral SCC cell lines...
June 8, 2017: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28598999/lymphatic-endothelial-progenitors-originate-from-plastic-myeloid-cells-activated-by-toll-like-receptor-4
#9
Lisa D Volk-Draper, Kelly L Hall, Andrew C Wilber, Sophia Ran
BACKGROUND: Myeloid-derived lymphatic endothelial cells (M-LECP) are induced by inflammation and play an important role in adult lymphangiogenesis. However, the mechanisms driving M-LECP differentiation are currently unclear. We previously showed that activation of Toll-like receptor-4 (TLR4) induces myeloid-lymphatic transition (MLT) of immortalized mouse myeloid cells. Here the goals were to assess the potential of different TLR4 ligands to induce pro-lymphatic reprogramming in human and mouse primary myeloid cells and to identify transcriptional changes regulating this process...
2017: PloS One
https://www.readbyqxmd.com/read/28594849/high-sodium-diet-converts-renal-proteoglycans-into-pro-inflammatory-mediators-in-rats
#10
Ryanne S Hijmans, Pragyi Shrestha, Kwaku A Sarpong, Saleh Yazdani, Rana El Masri, Wilhelmina H A de Jong, Gerjan Navis, Romain R Vivès, Jacob van den Born
BACKGROUND: High dietary sodium aggravates renal disease by affecting blood pressure and by its recently shown pro-inflammatory and pro-fibrotic effects. Moreover, pro-inflammatory modification of renal heparan sulfate (HS) can induce tissue remodeling. We aim to investigate if high sodium intake in normotensive rats converts renal HS into a pro-inflammatory phenotype, able to bind more sodium and orchestrate inflammation, fibrosis and lymphangiogenesis. METHODS: Wistar rats received a normal diet for 4 weeks, or 8% NaCl diet for 2 or 4 weeks...
2017: PloS One
https://www.readbyqxmd.com/read/28592537/role-of-autophagy-in-the-hiv-1-matrix-protein-p17-driven-lymphangiogenesis
#11
Pietro Mazzuca, Stefania Marsico, Kai Schulze, Stefania Mitola, Marina C Pils, Cinzia Giagulli, Carlos A Guzman, Arnaldo Caruso, Francesca Caccuri
AIDS-related lymphomas (ARLs) are expected to increase in the future since combined antiretroviral therapy (cART) enhances the life expectancy of HIV-1-infected (HIV(+)) patients, but does not affect the occurrence of ARLs to the same extent as of other tumors. Lymphangiogenesis is essential in supporting growth and metastatic spreading of ARLs. HIV-1 does not infect the neoplastic B cells, but HIV-1 proteins have been hypothesized to play a key role in sustaining a pro-lymphangiogenic microenvironment in lymphoid organs...
June 7, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28589086/lymph-node-metastases-in-papillary-and-medullary-thyroid-carcinoma-are-independent-of-intratumoral-lymphatic-vessel-density
#12
Filipe Pereira, Sofia S Pereira, Marta Mesquita, Tiago Morais, Madalena M Costa, Pedro Quelhas, Carlos Lopes, Mariana P Monteiro, Valeriano Leite
BACKGROUND: Blood and lymph vessel invasion are well-recognized markers of tumor aggressiveness, as these are the routes that lead to metastases. Thyroid tumors, depending on the histological variant, tend to have distinctive biological behaviors and use different vascular routes to metastasize, yet the mechanisms underlying the metastatic process are still poorly understood. OBJECTIVES: The aim of this study was to assess how the lymph vessel density (LVD) in different histological types of thyroid tumors, and in their surrounding tissue, correlate with the presence of lymph node metastases (LNM) and tumor pathological features...
April 2017: European Thyroid Journal
https://www.readbyqxmd.com/read/28586719/a-heparin-conjugate-lhbisd4-inhibits-lymphangiogenesis-and-attenuates-lymph-node-metastasis-by-blocking-vegf-c-signaling-pathway
#13
Jeong Uk Choi, Seung Woo Chung, Taslim A Al-Hilal, Farzana Alam, Jooho Park, Foyez Mahmud, Jee-Heon Jeong, Sang Yoon Kim, Youngro Byun
Clinical studies have found that the incidence of cancer metastasis through the lymphatic vessels are 3-5 times higher than that through the blood vessels. These findings suggest the potency of anti-lymphangiogenic therapy in reducing the incidence of cancer metastasis. Previously, we reported LHbisD4, which is the conjugate of low molecular weight heparin (LMWH) and four bis-deoxycholates as a potent anti-angiogenic drug with less toxicity and orally active property. Here, we show that LHbisD4 could also suppress the formation of new lymphatic vessels and attenuate the incidence of metastasis by blocking VEGF-C signaling pathway...
September 2017: Biomaterials
https://www.readbyqxmd.com/read/28545716/connective-tissue-growth-factor-regulates-fibrosis-associated-renal-lymphangiogenesis
#14
Hiroshi Kinashi, Lucas L Falke, Tri Q Nguyen, Niels Bovenschen, Jan Aten, Andrew Leask, Yasuhiko Ito, Roel Goldschmeding
Lymphangiogenesis is correlated with the degree of renal interstitial fibrosis. Pro-fibrotic transforming growth factor β induces VEGF-C production, the main driver of lymphangiogenesis. Connective tissue growth factor (CTGF) is an important determinant of fibrotic tissue remodeling, but its possible involvement in lymphangiogenesis has not been explored. We found prominent lymphangiogenesis during tubulointerstitial fibrosis to be associated with increased expression of CTGF and VEGF-C in human obstructed nephropathy as well as in diabetic kidney disease...
May 23, 2017: Kidney International
https://www.readbyqxmd.com/read/28544639/biomimetic-model-of-tumor-microenvironment-on-microfluidic-platform
#15
Minhwan Chung, Jungho Ahn, Kyungmin Son, Sudong Kim, Noo Li Jeon
The "Tumor microenvironment" (TME) is a complex, interacting system of the tumor and its surrounding environment. The TME has drawn more attention recently in attempts to overcome current drug resistance and the recurrence of cancer by understanding the cancer and its microenvironment systematically, beyond past reductionist approaches. However, a lack of experimental tools to dissect the intricate interactions has hampered in-depth research into the TME. Here, a biomimetic TME model using a microfluidic platform is presented, which enables the interaction between TME constituents to be studied in a comprehensive manner...
May 24, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28534984/ccl21-ccr7-interaction-promotes-cellular-migration-and-invasion-via-modulation-of-the-mek-erk1-2-signaling-pathway-and-correlates-with-lymphatic-metastatic-spread-and-poor-prognosis-in-urinary-bladder-cancer
#16
Yang Xiong, Fang Huang, Xiaozhou Li, Zhi Chen, Deyun Feng, Haiying Jiang, Wei Chen, Xiangyang Zhang
Lymph node metastasis in patients with urinary bladder cancer (UBC) is always associated with poor prognosis and is the determinant for tumor staging and the development of treatment regimens; however, its underlying mechanisms remain to be studied. Immunohistochemical staining of tumor sections from 62 UBC patients was performed using CCR7, D2-40 and CD34 antibodies. We showed that increased CCR7 expression was significantly associated with positive lymph node status (P=0.008), pT3-T4 tumor stage (P=0.015), tumor grade (P=0...
May 17, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28518106/isolation-of-murine-adipose-tissue-derived-microvascular-fragments-as-vascularization-units-for-tissue-engineering
#17
Florian S Frueh, Thomas Später, Claudia Scheuer, Michael D Menger, Matthias W Laschke
A functional microvascular network is of pivotal importance for the survival and integration of engineered tissue constructs. For this purpose, several angiogenic and prevascularization strategies have been established. However, most cell-based approaches include time-consuming in vitro steps for the formation of a microvascular network. Hence, they are not suitable for intraoperative one-step procedures. Adipose tissue-derived microvascular fragments (ad-MVF) represent promising vascularization units. They can be easily isolated from fat tissue and exhibit a functional microvessel morphology...
April 30, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28505676/-new-therapeutic-approaches-in-inflammatory-diseases-of-the-eye-targeting-lymphangiogenesis-and-cellular-immunity-research-unit-for-2240-presents-itself
#18
Claus Cursiefen, Felix Bock, Thomas Clahsen, Birgit Regenfuss, Andre Reis, Philipp Steven, Ludwig M Heindl, Jacobus J Bosch, Deniz Hos, Sabine Eming, Rafael Grajewski, Arnd Heiligenhaus, Sascha Fauser, Jennifer Austin, Thomas Langmann
Background Ophthalmology, principally, is a very successful subdiscipline in medicine. Nonetheless, there are still unmet medical needs which necessitate translational research. Methods The funding instrument of a Research Unit (RU) of the German Research Foundation (DFG) is presented as exemplified by the RU 2240 at the Department of Ophthalmology at the University of Cologne. Results The Research Unit integrates different research groups working on pathologic ocular inflammation, macrophages/microglia and (lymph)angiogenesis to collaborate in a synergistic way...
May 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28505674/-novel-adjuvant-therapy-for-ocular-melanoma
#19
Jacobus J Bosch, Ludwig M Heindl
Background Malignant melanoma is the most common cancer of the eye in adults that originates either in the intra-ocular uveal tract or extra-ocular conjunctiva. Although the primary tumor can be treated successfully, no effective therapy for both metastatic conjunctival and uveal melanoma currently exits. Tumor-associated lymphangiogenesis and immune cell infiltration play a pivotal role in the development and therapeutic targeting of metastases. Project description Here, we provide an overview of current translational research on lymphangiogenesis and its therapeutic inhibition as well as modulation of immune cell infiltration by passive and active immunotherapy in melanoma of the eye...
May 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28497372/scara5-plays-a-critical-role-in-the-progression-and-metastasis-of-breast-cancer-by-inactivating-the-erk1-2-stat3-and-akt-signaling-pathways
#20
Kai You, Fei Su, Lihua Liu, Xiaohong Lv, Jianguo Zhang, Yafang Zhang, Baoquan Liu
Scavenger receptor class A member 5 (SCARA5) is a candidate anti-oncogene in several malignancies. However, whether SCARA5 is a suppressor gene in breast cancer and its role in breast cancer cell growth and metastasis remain to be determined. Here, we investigated the biological functions of SCARA5 in the progression and metastasis of breast cancer and explored the underlying mechanisms. A total of 65 breast cancer patients and three cell lines (ZR-75-30, MCF-7, and MDA-MB-231) were analyzed in the study. RT-qPCR, western blotting, and immunohistochemistry were used to detect mRNA and protein expression, and lymphatic vessel density (LVD) and microvessel density (MVD)...
May 11, 2017: Molecular and Cellular Biochemistry
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