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Lymphangiogenesis

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https://www.readbyqxmd.com/read/28912626/clinical-impact-of-sphingosine-1-phosphate-in-breast-cancer
#1
REVIEW
Junko Tsuchida, Masayuki Nagahashi, Kazuaki Takabe, Toshifumi Wakai
Breast cancer metastasizes to lymph nodes or other organs, which determine the prognosis of patients. It is difficult to cure the breast cancer patients with distant metastasis due to resistance to drug therapies. Elucidating the underlying mechanisms of breast cancer metastasis and drug resistance is expected to provide new therapeutic targets. Sphingosine-1-phosphate (S1P) is a pleiotropic, bioactive lipid mediator that regulates many cellular functions, including proliferation, migration, survival, angiogenesis/lymphangiogenesis, and immune responses...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28910489/nucleoside-nucleotide-reverse-transcriptase-inhibitors-attenuate-angiogenesis-and-lymphangiogenesis-by-impairing-receptor-tyrosine-kinases-signalling-in-endothelial-cells
#2
Lin Song, Sha Ding, Zhen Ge, Xiaolong Zhu, Cong Qiu, Yuewen Wang, Enyin Lai, Weijun Yang, Yi Sun, Samson A Chow, Luyang Yu
BACKGROUND AND PURPOSE: Cardiovascular disease associated with antiretroviral therapy (ART) has become a major clinical challenge for HIV-positive patients. However, the role of ART in blood vessel growth is largely unknown. Here, we examined an integral component of ART, nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs), and investigated their effects on key microvascular functions, including angiogenesis and lymphangiogenesis. EXPERIMENTAL APPROACH: The angiogenesis/lymphangiogenesis capability of endothelial cells (ECs) was evaluated using migration, proliferation and tube formation assays in vitro, and mouse ear and Matrigel plug assays in vivo...
September 14, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28904226/tumor-lymphangiogenesis-promotes-t-cell-infiltration-and-potentiates-immunotherapy-in-melanoma
#3
Manuel Fankhauser, Maria A S Broggi, Lambert Potin, Natacha Bordry, Laura Jeanbart, Amanda W Lund, Elodie Da Costa, Sylvie Hauert, Marcela Rincon-Restrepo, Christopher Tremblay, Elena Cabello, Krisztian Homicsko, Olivier Michielin, Douglas Hanahan, Daniel E Speiser, Melody A Swartz
In melanoma, vascular endothelial growth factor-C (VEGF-C) expression and consequent lymphangiogenesis correlate with metastasis and poor prognosis. VEGF-C also promotes tumor immunosuppression, suggesting that lymphangiogenesis inhibitors may be clinically useful in combination with immunotherapy. We addressed this concept in mouse melanoma models with VEGF receptor-3 (VEGFR-3)-blocking antibodies and unexpectedly found that VEGF-C signaling enhanced rather than suppressed the response to immunotherapy. We further found that this effect was mediated by VEGF-C-induced CCL21 and tumor infiltration of naïve T cells before immunotherapy because CCR7 blockade reversed the potentiating effects of VEGF-C...
September 13, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28900118/arf6-in-lymphatic-endothelial-cells-regulates-lymphangiogenesis-by-controlling-directional-cell-migration
#4
Yueh-Chien Lin, Norihiko Ohbayashi, Tsunaki Hongu, Naohiro Katagiri, Yuji Funakoshi, Hsinyu Lee, Yasunori Kanaho
The small GTPase Arf6 plays pivotal roles in a wide variety of cellular events such as endocytosis, exocytosis, and actin cytoskeleton reorganization. However, the physiological functions of Arf6 at the whole animal level have not yet been thoroughly understood. Here, we show that Arf6 regulates developmental and tumor lymphangiogenesis in mice. Lymphatic endothelial cell (LEC)-specific Arf6 conditional knockout (LEC-Arf6 cKO) mouse embryos exhibit severe skin edema and impairment in the formation of lymphatic vessel network at the mid-gestation stage...
September 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28878285/interleukin-33-promotes-inflammation-induced-lymphangiogenesis-via-st2-traf6-mediated-akt-enos-no-signalling-pathway
#5
Longhui Han, Minglian Zhang, Xu Liang, Xin Jia, Jinchen Jia, Miying Zhao, Yiming Fan
The interplay between inflammation and lymphangiogenesis is mediated by various cytokines. However, most of these molecules and their associated mechanism are yet to be defined. Here, we explored the role of IL-33 in modulating inflammation-induced lymphangiogenesis (ILA) and its underlying mechanisms using an ILA mouse model and a lymphatic endothelial cell (LEC) line. Our results show that IL-33 promoted the proliferation, migration and tube formation of LECs and ILA in vivo. The pro-lymphangiogenic activity of IL-33 was abolished by ST2 blockage...
September 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28877002/lymphedema-pathogenesis-and-novel-therapies
#6
Joseph H Dayan, Catherine L Ly, Raghu P Kataru, Babak J Mehrara
Lymphedema affects up to 1 in 6 patients who undergo treatment for a solid tumor in the United States. Its prevalence has increased as more effective oncologic therapies have improved patient survival, but there remains no definitive cure. Recent research has elucidated new details in the pathogenesis of the disease and has demonstrated that it is fundamentally an immunologic progress that ultimately results in inflammation, fibroadipose deposition, impaired lymphangiogenesis, and dysfunctional lymphatic pumping...
September 6, 2017: Annual Review of Medicine
https://www.readbyqxmd.com/read/28855985/the-optimum-marker-for-the-detection-of-lymphatic-vessels
#7
Ling-Ling Kong, Nian-Zhao Yang, Liang-Hui Shi, Guo-Hai Zhao, Wenbin Zhou, Qiang Ding, Ming-Hai Wang, Yi-Sheng Zhang
Podoplanin, lymphatic vessel endothelial hyaluronic acid receptor-1, prospero-related homeobox-1 and vascular endothelial growth factor receptor 3 have been demonstrated to have crucial roles in the development of the lymphatic system and lymphangiogenesis process by combining with their corresponding receptors. Thus, the four markers have been widely used in labelling lymphatic vessels for the detection of lymphangiogenesis and lymphatic vessel invasion. Numerous authors have aimed to identify the roles of these four markers in the lymphatic system and the mechanisms have been partly clarified at the molecular level...
October 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28845514/neoadjuvant-hormonal-therapy-for-low-risk-prostate-cancer-induces-biochemical-recurrence-after-radical-prostatectomy-via-increased-lymphangiogenesis-related-parameters
#8
Yasuyoshi Miyata, Yuichiro Nakamura, Takuji Yasuda, Tomohiro Matsuo, Kojiro Ohba, Bungo Furusato, Junya Fukuoka, Hideki Sakai
BACKGROUND: The effects of neoadjuvant hormonal therapy (NHT) on pathological features and lymphangiogenesis in patients with prostate cancer (PCa) for each pre-operative risk classification are unclear. METHODS: To clarify the anti-cancer effects of NHT, we investigated 153 patients (non-NHT group = 80 and NHT group = 73) who underwent radical prostatectomy (RP) in Nagasaki University Hospital. Lymph vessel density and area (evaluated by D2-40-positive vessels), vascular endothelial growth factor (VEGF)-C and VEGF-D expressions, and biochemical recurrence (BCR)-free survival were compared between these two groups for each D'Amico risk classification (low = 33, intermediate = 58, high = 62 patients)...
August 28, 2017: Prostate
https://www.readbyqxmd.com/read/28844941/paracrine-activin-a-signaling-promotes-melanoma-growth-and-metastasis-through-immune-evasion
#9
Prudence Donovan, Olivier A Dubey, Susanna Kallioinen, Katherine W Rogers, Katja Muehlethaler, Patrick Müller, Donata Rimoldi, Daniel B Constam
The secreted growth factor Activin-A of the TGFβ family and its receptors can promote or inhibit several cancer hallmarks including tumor cell proliferation and differentiation, vascularization, lymphangiogenesis and inflammation. However, a role in immune evasion and its relationship with tumor-induced muscle wasting and tumor vascularization, and the relative contributions of autocrine versus paracrine Activin signaling remain to be evaluated. To address this, we compared the effects of truncated soluble Activin receptor II B as a ligand trap, or constitutively active mutant type IB receptor versus secreted Activin-A or the related ligand Nodal in mouse and human melanoma cell lines and tumor grafts...
August 24, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28843905/role-of-neuropilin-2-in-the-immune-system
#10
REVIEW
S Schellenburg, A Schulz, D M Poitz, M H Muders
Neuropilins (NRPs) are single transmembrane receptors with short cytoplasmic tails and are dependent on receptors like VEGF receptors or Plexins for signal transduction. NRPs are known to be important in angiogenesis, lymphangiogenesis, and axon guidance. The Neuropilin-family consists of two members, Neuropilin-1 (NRP1) and Neuropilin-2 (NRP2). They are up to 44 % homologous and conserved in all vertebrates. High levels of NRP2 are found on immune cells. Current research is very limited regarding the functions of NRP2 on these cells...
August 24, 2017: Molecular Immunology
https://www.readbyqxmd.com/read/28843751/thyroid-transcription-factor-1-promotes-lymph-node-metastasis-by-inducing-lymphangiogenesis-in-ovarian-carcinoma
#11
Minhua Li, Weiping Zheng, Jianguo Wei, Chuanling Hou, Ye Yang, Liping Sun, Cheng Wang
AIMS AND BACKGROUND: Thyroid transcription factor-1 (TTF-1) expression is widely considered a specific marker for lung and thyroid carcinomas and plays an important role in angiogenesis in lung cancer. However, it can occasionally be expressed in other malignancies, including ovarian carcinomas, and the mechanism of TTF-1 in lymphatic metastasis of ovarian carcinomas is still unclear. This study aimed to define the TTF-1 expression and lymph vessel density (LVD) in ovarian carcinomas and look for their correlations with clinicopathological features...
August 1, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28837798/lymphotoxins-promote-the-progression-of-human-lymphatic-malformation-by-enhancing-lymphatic-endothelial-cell-proliferation
#12
Jie-Gang Yang, Yan-Fang Sun, Ke-Fei He, Jian-Gang Ren, Zhuo-Jue Liu, Bing Liu, Wei Zhang, Yi-Fang Zhao
Formation of inflammation-related tertiary lymphoid organs promotes human lymphatic malformation (LM) development. However, the role of lymphotoxins (LTs) and LT-related inducible ligand, the crucial mediators for tertiary lymphoid organ formation, is undetermined in LMs. Herein, we show that LTs and LT-related inducible ligand promote LM development by enhancing lymphatic endothelial cell (LEC) proliferation via activating NF-κB pathways. The expression of LTs and their receptors was increased in LMs, especially the infected ones, when compared with normal skins...
August 21, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/28819375/bone-marrow-derived-mesenchymal-stem-cells-involve-in-the-lymphangiogenesis-of-lung-cancer-and-jinfukang-inhibits-the-involvement-in-vivo
#13
Xian-Mei Zhou, Dan Wang, Hai-Lang He, Jie Tang, Jing Wu, Ling Xu, Jian-Xin Li
Lymphangiogenesis plays an important role in cancer metastasis. Bone marrow-derived mesenchymal stem cells (BMMSCs) migrate to the site of tumorigenesis and in turn promote the metastasis. However, whether BMMSCs involve in the lymphangiogenesis of lung cancer is unclear. Jinfukang has clinically been used for the treatment of non small cell lung cancer (NSCLC) in China. In this study, to investigate the involvement of BMMSCs in lymphangiogenesis in lung cancer, and evaluate the inhibitory effect of Jinfukang on the lymphangiogenesis, chimeric mice were prepared by transplanting bone marrow from green fluorescent protein (GFP) transgenic mice (C57BL/6-EGFP) into irradiated C57BL/6 mice...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28804221/s1p-provokes-tumor-lymphangiogenesis-via-macrophage-derived-mediators-such-as-il-1%C3%AE-or-lipocalin-2
#14
REVIEW
Shahzad N Syed, Michaela Jung, Andreas Weigert, Bernhard Brüne
A pleiotropic signaling lipid, sphingosine-1-phosphate (S1P), has been implicated in various pathophysiological processes supporting tumor growth and metastasis. However, there are only a few descriptive studies suggesting a role of S1P in tumor lymphangiogenesis, which is critical for tumor growth and dissemination. Corroborating own data, the literature suggests that apoptotic tumor cell-derived S1P alters the phenotype of tumor-associated macrophages (TAMs) to gain protumor functions. However, mechanistically, the role of TAM-induced lymphangiogenesis has only been poorly described, mostly linked to the production of lymphangiogenic factors such as vascular endothelial growth factor C (VEGF-C) and VEGF-D, or transdifferentiation into lymphatic endothelial cells...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28795242/prox1-gfp-flt1-dsred-transgenic-mice-an-animal-model-for-simultaneous-live-imaging-of-angiogenesis-and-lymphangiogenesis
#15
Wei Zhong, Xinbo Gao, Shuangyong Wang, Kyuyeon Han, Masatsugu Ema, Susanne Adams, Ralf H Adams, Mark I Rosenblatt, Jin-Hong Chang, Dimitri T Azar
The roles of angiogenesis in development, health, and disease have been studied extensively; however, the studies related to lymphatic system are limited due to the difficulty in observing colorless lymphatic vessels. But recently, with the improved technique, the relative importance of the lymphatic system is just being revealed. We bred transgenic mice in which lymphatic endothelial cells express GFP (Prox1-GFP) with mice in which vascular endothelial cells express DsRed (Flt1-DsRed) to generate Prox1-GFP/Flt1-DsRed (PGFD) mice...
August 9, 2017: Angiogenesis
https://www.readbyqxmd.com/read/28791841/vascular-endothelial-growth-factor-vegf-c-vegf-d-vegfr-3-and-d2-40-expressions-in-primary-breast-cancer-association-with-lymph-node-metastasis
#16
Aydan Eroğlu, Cevriye Ersöz, Durdu Karasoy, Serpil Sak
BACKGROUND: Two members of the vascular endothelial growth factor (VEGF) family, VEGF-C and -D, are known as lymphangiogenic growth factors and play an important role in tumor lymphangiogenesis via activation of the VEGF receptor (VEGFR)-3, which is expressed in lymphatic endothelial cells. D2-40 is a specific antibody for lymphatic vessel density (LVD). OBJECTIVES: In the present study, we have aimed to evaluate whether intraand peri-tumoral D2-40-positive lymphatic vessels affect lymph node metastasis and to investigate the relationship between LVD and lymph node metastasis in breast cancer...
March 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28775329/transient-ingrowth-of-lymphatic-vessels-into-the-physiologically-avascular-cornea-regulates-corneal-edema-and-transparency
#17
Deniz Hos, Anne Bukowiecki, Jens Horstmann, Felix Bock, Franziska Bucher, Ludwig M Heindl, Sebastian Siebelmann, Philipp Steven, Reza Dana, Sabine A Eming, Claus Cursiefen
Lymphangiogenesis is essential for fluid homeostasis in vascularized tissues. In the normally avascular cornea, however, pathological lymphangiogenesis mediates diseases like corneal transplant rejection, dry eye disease, and allergy. So far, a physiological role for lymphangiogenesis in a primarily avascular site such as the cornea has not been described. Using a mouse model of perforating corneal injury that causes acute and severe fluid accumulation in the cornea, we show that lymphatics transiently and selectively invade the cornea and regulate the resolution of corneal edema...
August 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28771226/brain-derived-neurotrophic-factor-promotes-vegf-c-dependent-lymphangiogenesis-by-suppressing-mir-624-3p-in-human-chondrosarcoma-cells
#18
Chih-Yang Lin, Shih-Wei Wang, Yen-Ling Chen, Wen-Yi Chou, Ting-Yi Lin, Wei-Cheng Chen, Chen-Yu Yang, Shih-Chia Liu, Chia-Chu Hsieh, Yi-Chin Fong, Po-Chuan Wang, Chih-Hsin Tang
Chondrosarcoma is the second most common primary malignancy of bone, and one of the most difficult bone tumors to diagnose and treat. It is well known that increased levels of vascular endothelial growth factor-C (VEGF-C) promote active tumor lymphangiogenesis and lymphatic tumor spread to regional lymph nodes. Brain-derived neurotrophic factor (BDNF) is known to promote metastasis in human chondrosarcoma cells. Knowing more about the mechanism of BDNF in VEGF-C expression and lymphangiogenesis in human chondrosarcoma would improve our understanding as how to prevent chondrosarcoma angiogenesis and metastasis, which currently lacks effective adjuvant treatment...
August 3, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28762169/successful-surgical-treatment-of-intractable-chylous-ascites-using-the-lymphatic-cable-flap-a-retrospective-review-study
#19
Shih-Heng Chen, Li-Fan Yeh, Pedro Ciudad, Hung-Chi Chen
OBJECTIVE: For evaluation of a novel surgical procedure for the treatment of chylous ascites. Chylous ascites is a debilitating condition associated with high morbidity and mortality rates. At least one-third of patients are refractory to medical therapy and may warrant further treatment. Traditional methods involving ligation of lymphatic fistulas or small bowel resection do not address the basic pathophysiologic mechanism of the underlying obstruction, and identification of chyloperitoneal fistulas may be challenging...
July 31, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28756632/lymphangiogenesis-from-passive-disseminator-to-dynamic-metastatic-enabler
#20
Eva Perez Guijarro, Glenn Merlino
The lymphatic vasculature drains fluid and cells from tissues and channels them to the lymph nodes, where they encounter immune cells, constituting a critical component of immune function and tissue fluid homeostasis. It has been hypothesized that the formation of new lymphatics (lymphangiogenesis) in tumors can facilitate cancer cell transport to the lymph node, whose permissive microenvironment would favor their survival before disseminating to other organs. However, lymphatic vessels found inside tumors are generally not functional and surgical resection of sentinel lymph nodes does not improve melanoma patient's outcome (Morton et al...
July 30, 2017: Pigment Cell & Melanoma Research
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