Luiz Gustavo Almeida de Carvalho, Tatiana Takahasi Komoto, Daniel Antunes Moreno, João Vitor Caetano Goes, Roberta Taiane Germano de Oliveira, Mayara Magna de Lima Melo, Mariela Estefany Gislene Vera Roa, Paola Gyuliane Gonçalves, Carlos Victor Montefusco-Pereira, Ronald Feitosa Pinheiro, Howard Lopes Ribeiro Junior
The aim of this study was to evaluate the expression of USP7 , USP15 , UBE2O , and UBE2T genes in Myelodysplastic neoplasm (MDS) to identify possible targets of ubiquitination and deubiquitination in MDS pathobiology. To achieve this, eight datasets from the Gene Expression Omnibus (GEO) database were integrated, and the expression relationship of these genes was analyzed in 1092 MDS patients and healthy controls. Our results showed that UBE2O , UBE2T , and USP7 were upregulated in MDS patients compared with healthy individuals, but only in mononucleated cells collected from bone marrow samples ( p < 0...
June 13, 2023: International Journal of Molecular Sciences