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catheter bacteremia

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https://www.readbyqxmd.com/read/29227744/molecular-epidemiology-of-klebsiella-pneumoniae-strains-causing-bloodstream-infections-in-adults
#1
Meritxell Cubero, Imma Grau, Fe Tubau, Román Pallarés, M Ángeles Domínguez, Josefina Liñares, Carmen Ardanuy
Molecular epidemiology of Klebsiella pneumoniae bacteremic strains allows for a better understanding of preventive and therapeutic strategies. Clinical and microbiological characteristics of 348 K. pneumoniae bacteremia cases (2007-2009) were retrospectively characterized by multilocus sequence typing and extended-spectrum beta-lactamases (ESBL) production. Overall, 223 (64.08%) cases were nosocomial (NA), 58 (16.67%) healthcare associated, and 67 (19.25%) community acquired. The main infection origins were urinary tract (16...
December 11, 2017: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/29222405/multiple-weekly-dalbavancin-dosing-for-the-treatment-of-native-vertebral-osteomyelitis-caused-by-methicillin-resistant-staphylococcus-aureus-a-case-report
#2
Thamer A Almangour, Valerie Fletcher, Mohammed Alessa, Abdullah A Alhifany, Deanne Tabb
BACKGROUND Native vertebral osteomyelitis (NVO) is a common form of hematogenous osteomyelitis, with Staphylococcus aureus (S. aureus) being the most commonly isolated organism. Dalbavancin is approved by the US Food and Drug Administration (FDA) for the treatment of acute bacterial skin and skin structure infections (ABSSSI) and has a sufficiently promising pharmacokinetic and pharmacodynamic profile to be considered for the treatment of vertebral osteomyelitis. We describe here what is probably the first reported case of using multiple weekly dalbavancin to treat a complicated methicillin-resistant Staphylococcus aureus (MRSA) bacteremia and vertebral osteomyelitis...
December 9, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/29221439/catheter-related-blood-stream-infections-in-hemodialysis-patients-a-prospective-cohort-study
#3
Stephanie Thompson, Natasha Wiebe, Scott Klarenbach, Rick Pelletier, Brenda R Hemmelgarn, John S Gill, Braden J Manns, Marcello Tonelli
BACKGROUND: For people requiring hemodialysis, infectious mortality is independently associated with geographic distance from a nephrologist. We aimed to determine if differential management of catheter-related blood stream infections (CRBSIs) could explain poorer outcomes. METHODS: We prospectively collected data from adults initiating hemodialysis with a central venous catheter between 2005 and 2015 in Alberta, Canada. We collected indicators of CRBSI management (timely catheter removal, relapsing bacteremia); frequency of CRBSIs; hospitalizations; predictors of CRBSIs, and bacteremia...
December 8, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/29200325/incidence-and-risk-factors-of-bacterial-and-fungal-infection-during-induction-chemotherapy-for-high-risk-neuroblastoma
#4
Sarah B Whittle, Kaitlin C Williamson, Heidi V Russell
High-risk neuroblastoma is an aggressive childhood cancer with poor outcomes. Treatment begins with an induction phase comprised of intense multi-agent chemotherapy with the goal of maximally reducing tumor bulk. Given the high intensity of induction chemotherapy, neutropenic fever and infectious complications are common; however, the actual incidence is difficult to determine from clinical trial reports. We performed a retrospective review of infection-related complications in 76 children treated for high-risk neuroblastoma at Texas Children's Hospital...
December 4, 2017: Pediatric Hematology and Oncology
https://www.readbyqxmd.com/read/29194493/not-your-garden-variety-bacteremia-gardnerella-in-an-immunocompromised-man
#5
Prerana Bhatia, John Temple, Molly Kantor
Gardnerella is a common colonizer of the genitourinary tract, but systemic Gardnerella infections are rare and are usually associated with surgical instrumentation of the genitourinary tract. Presented is a case of symptomatic and transient Gardnerella bacteremia in an adult male patient with AIDS following a traumatic urinary catheter insertion.
November 29, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29178957/triple-combination-antibiotic-therapy-for-carbapenemase-producing-klebsiella-pneumoniae-a-systematic-review
#6
REVIEW
David M Jacobs, M Courtney Safir, Dennis Huang, Faisal Minhaj, Adam Parker, Gauri G Rao
BACKGROUND: The spread of carbapenemase-producing K. pneumoniae (CPKP) has become a significant problem worldwide. Combination therapy for CPKP is encouraging, but polymyxin resistance to many antibiotics is hampering effective treatment. Combination therapy with three or more antibiotics is being increasingly reported, therefore we performed a systematic review of triple combination cases in an effort to evaluate their clinical effectiveness for CPKP infections. METHODS: The PubMed database was searched to identify all published clinical outcomes of CPKP infections treated with triple combination therapy...
November 25, 2017: Annals of Clinical Microbiology and Antimicrobials
https://www.readbyqxmd.com/read/29165507/-infectious-or-noninfectious-phlebitis-lessons-from-a-an-interventional-programm-on-phlebitis-associated-to-peripheral-venous-catheter
#7
Teresa Vergara, Elena Véliz, Alberto Fica, Jordan Leiva
BACKGROUND: There is no consensus definition to distinguish infectious from non-infectious phlebitis associated to peripheral venous catheter. AIMS: To evaluate the impact of an intervention program on the rate of infectious (those associated to bacteremia or local purulent discharge) and non-infectious phlebitis (the rest) and identify differential features. METHODS: Interventional study developed in three stages: basal measurement, intervention, and evaluation...
August 2017: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/29145887/postpartum-infective-endocarditis-with-enterococcus-faecalis-in-japan-a-case-report
#8
Miku Tamura, Mitsutaka Shoji, Ken Fujita, Shohei Nakamura, Yurika Takahashi, Yurika Suzuki, Mika Asakura, Shun Kimizuka, Makiko Sasaki, Katsuya Sugawara
BACKGROUND: The clinical characteristics of infective endocarditis include the presence of predisposing cardiac disease, a history of illegal drug use, and high morbidity in the elderly. Only a few cases of the disease after delivery have been reported in the literature. We describe here a first case of enterococcal postpartum infective endocarditis without underlying disease in Japan. CASE PRESENTATION: We report the case of a 31-year-old Japanese woman with postpartum infective endocarditis by Enterococcus faecalis...
November 17, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29142959/hemodialysis-infection-prevention-protocols-ontario-shower-technique-hippo-st-a-pilot-randomized-trial
#9
S Daisy Kosa, Amiram Gafni, Andrew A House, JulieAnn Lawrence, Louise Moist, Bharat Nathoo, Paul Tam, Alicia Sarabia, Lehana Thabane, George Wu, Charmaine E Lok
Introduction: We developed the Hemodialysis Infection Prevention Protocols Ontario-Shower Technique (HIPPO-ST) to permit hemodialysis (HD) patients with central venous catheters (catheters) to shower without additional infection risk. Our primary objective was to determine the feasibility of conducting a parallel randomized controlled trial (RCT) to evaluate the impact of HIPPO-ST on catheter-related bacteremia (CRB) in adult HD patients. Methods: Adult HD patients using catheters were recruited from 11 HD units...
March 2017: KI Reports
https://www.readbyqxmd.com/read/29050864/outpatient-parenteral-antibiotic-therapy-evaluation-of-practices-and-limits-of-use-in-rural-areas-in-france
#10
C Triffault-Fillit, T Ferry, T Perpoint, L Adélaïde, S Le Ngoc Tho, F Ader, C Chidiac, F Valour
OBJECTIVES: To evaluate outpatient parenteral antibiotic therapy (OPAT) practices in a French rural area. MATERIAL AND METHODS: Descriptive study assessing knowledge, practices, and limitations of OPAT use among hospital practitioners (HP), family physicians (FP), and private nurses (PN). RESULTS: OPAT (mainly ceftriaxone and penicillins) was used by 69.6%, 73.3%, and 97.7% of the 23 HPs, 45 FPs, and 46 PNs mostly for respiratory or urinary tract infections, bacteremia, and/or multidrug-resistant bacterial infections...
October 16, 2017: Médecine et Maladies Infectieuses
https://www.readbyqxmd.com/read/29026535/clinical-and-molecular-characteristics-risk-factors-and-outcomes-of-carbapenem-resistant-klebsiella-pneumoniae-bloodstream-infections-in-the-intensive-care-unit
#11
Xia Zheng, Jian-Feng Wang, Wang-Lan Xu, Jun Xu, Juan Hu
BACKGROUND: To analyze the clinical characteristics and outcomes of carbapenem-resistant Klebsiella pneumoniae (CRKp) and carbapenem-susceptible K. pneumoniae (CSKp) bloodstream infections (BSIs), and to study the risk factors for development of CRKp BSI and K. pneumoniae BSI-related mortality. METHODS: A retrospective case control study of patients with K. pneumoniae BSI was conducted in the intensive care unit of the First Affiliated Hospital, Medical of College, Zhejiang University from January 2013 to December 2014...
2017: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/29020942/peripherally-inserted-central-catheter-related-bloodstream-infection-due-to-tsukamurella-pulmonis-a-case-report-and-literature-review
#12
Jun Suzuki, Teppei Sasahara, Masaki Toshima, Yuji Morisawa
BACKGROUND: Tsukamurella pulmonis is an aerobic gram-positive and rod-shaped organism that causes central catheter-related bloodstream infections in immunocompromised hosts. However, peripherally inserted central catheter (PICC)-related bloodstream infections due to this organism have not been reported. CASE PRESENTATION: We describe a case of a 48-year-old man with acquired immunodeficiency syndrome and diffuse large B cell lymphoma who received five courses of chemotherapy including rituximab , cyclophosphamide , doxorubicin hydrochloride , vincristine , and prednisone via a PICC...
October 11, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29020307/follow-up-blood-cultures-in-gram-negative-bacteremia-are-they-needed
#13
Christina N Canzoneri, Bobak J Akhavan, Zehra Tosur, Pedro E Alcedo Andrade, Gabriel M Aisenberg
Background: Bloodstream infections remain a major cause of morbidity and mortality. Gram-negative bacilli (GNB) bacteremia is typically transient and usually resolves rapidly after the initiation of appropriate antibiotic therapy and source control. The optimal duration of treatment and utility of follow-up blood cultures (FUBC) have not been studied in detail. Currently, the management of gram-negative bacteremia is determined by clinical judgment. To investigate the value of repeat blood cultures, we analyzed 500 episodes of bacteremia to determine frequency of FUBC and identify risk factors for persistent bacteremia...
November 13, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29017247/a-17-year-nationwide-study-of-burkholderia-cepacia-complex-bloodstream-infections-among-patients-in-the-united-states-veterans-health-administration
#14
Nadim G El Chakhtoura, Elie Saade, Brigid M Wilson, Federico Perez, Krisztina M Papp-Wallace, Robert A Bonomo
Background: Burkholderia cepacia complex (Bcc) are a group of multidrug-resistant gram-negative bacteria rarely reported in patients without cystic fibrosis (CF) or immunocompromising conditions. We investigated Bcc bloodstream infections (BSIs) in a cohort of non-CF patients from the US Veterans Health Administration (VHA). Methods: Using VHA databases, we identified patients with Bcc BSI at facilities nationwide from 1999 through 2015. We ascertained clinical characteristics, treatments, and outcomes and identified factors associated with 30-day mortality in logistic regression analysis...
October 15, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28962996/low-incidence-of-subsequent-bacteremia-or-fungemia-after-removal-of-a-colonized-intravascular-catheter-tip
#15
Niccolò Buetti, Elia Lo Priore, Andrew Atkinson, Andreas Kronenberg, Jonas Marschall
OBJECTIVES: We determined the frequency of subsequent bloodstream infection >2 days after removal of a catheter with positive tip cultures. METHODS: We conducted a nationwide, observational study on intravascular catheter (IVC) tip cultures in Switzerland from 2008 to 2015 using data from the Swiss Antibiotic Resistance Surveillance System (ANRESIS). An IVC tip culture was included in the analysis if ≥1 microorganism could be cultivated from it. We excluded all data from patients with concurrent bacteremia with the same microorganism identified 7 days before to 2 days after IVC removal...
September 26, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28958447/an-outbreak-of-bloodstream-infection-due-to-extensively-resistant-acinetobacter-baumannii-among-neonates
#16
Aysegul Ulu-Kilic, Aycan Gundogdu, Fatma Cevahir, Huseyin Kilic, Tamer Gunes, Emine Alp
BACKGROUND: Extensively resistant Acinetobacter baumannii has emerged and spread worldwide as a significant cause of health care-associated infections and outbreaks. It also causes life-threatening infections among neonates, including bacteremia. The aim of this study was to investigate an outbreak of A baumannii bacteremia (ABB) among neonates. MATERIALS AND METHODS: A retrospective, case-control study was conducted from July 2014 to July 2015 in a neonatal intensive care unit (NICU)...
September 25, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/28948347/central-venous-catheter-salvage-in-children-with-staphylococcus-aureus-central-line-associated-bloodstream-infection
#17
Kristine S Corkum, Rachel E Jones, Caroline H Reuter, Larry K Kociolek, Elaine Morgan, Timothy B Lautz
BACKGROUND: Prompt central venous catheter (CVC) removal is currently recommended in children with Staphylococcus aureus central line-associated bloodstream infection (CLABSI). Our objective was to examine the outcome of attempted line salvage in children with S. aureus CLABSI and assess predictors of success. METHODS: A single-institution, retrospective cohort study was performed of all children with S. aureus CLABSI between 2012 and 2015. Patients with and without immediate CVC removal (≤ 2 days after first positive culture) were compared...
November 2017: Pediatric Surgery International
https://www.readbyqxmd.com/read/28934890/hyperglycemic-episodes-are-associated-with-postoperative-infections-after-cardiac-surgery
#18
K M Järvelä, N K Khan, E L Loisa, J A Sutinen, J O Laurikka, J A Khan
BACKGROUND AND AIMS: To describe the incidence of and risk factors for postoperative infections and the correlation between postoperative hyperglycemia despite tight blood glucose control with infectious and other complications after contemporary cardiac surgery. MATERIAL AND METHODS: The study comprised 1356 consecutive adult patients who underwent cardiac surgery between January 2013 and December 2014 and were followed up for 6 months. Patients surviving the first 2 days were included in the analysis...
September 1, 2017: Scandinavian Journal of Surgery: SJS
https://www.readbyqxmd.com/read/28904973/effects-of-bacillus-serine-proteases-on-the-bacterial-biofilms
#19
Olga Mitrofanova, Ayslu Mardanova, Vladimir Evtugyn, Lydia Bogomolnaya, Margarita Sharipova
Serratia marcescens is an emerging opportunistic pathogen responsible for many hospital-acquired infections including catheter-associated bacteremia and urinary tract and respiratory tract infections. Biofilm formation is one of the mechanisms employed by S. marcescens to increase its virulence and pathogenicity. Here, we have investigated the main steps of the biofilm formation by S. marcescens SR 41-8000. It was found that the biofilm growth is stimulated by the nutrient-rich environment. The time-course experiments showed that S...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28891072/stable-control-of-physiological-parameters-but-not-infection-in-preterm-lambs-maintained-on-ex-vivo-uterine-environment-therapy
#20
Yuichiro Miura, Haruo Usuda, Shimpei Watanabe, Eleanor Woodward, Masatoshi Saito, Gabrielle C Musk, Suhas G Kallapur, Shinichi Sato, Ryuta Kitanishi, Tadashi Matsuda, John P Newnham, Sarah J Stock, Matthew W Kemp
Ex vivo uterine environment (EVE) therapy is an experimental neonatal intensive care strategy wherein gas exchange is performed by membranous oxygenators attached to the umbilical vessels. Our aim was to assess the ability of a newly refined EVE system to maintain key physiological parameters in preterm lambs within optimal ranges for 48 h. EVE group; n = 6: Preterm lambs were delivered under general anesthesia at 115 ± 2 days of gestational age. Animals were submerged in a bath of artificial amniotic fluid on EVE therapy for 48 h...
September 11, 2017: Artificial Organs
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