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https://www.readbyqxmd.com/read/28636974/sema3a-partially-reverses-vegf-effects-through-binding-to-neuropilin-1
#1
Bruna Palodetto, Adriana da Silva Santos Duarte, Matheus Rodrigues Lopes, Flavia Adolfo Corrocher, Fernanda Marconi Roversi, Fernanda Soares Niemann, Karla Priscila Vieira Ferro, Ana Leda Figueiredo Longhini, Paula Melo Campos, Patricia Favaro, Sara Teresinha Olalla Saad
Cross-talk between hematopoietic stem cells (HSCs) and bone marrow stromal cells (BMSCs) is essential for HSCs regulation and leukemogenesis. Studying bone marrow of myelodysplasia patients, a pre-leukemic condition, we found mRNA overexpression of vascular endothelial growth factor A (VEGFA) in CD34(+) HSCs and semaphorin 3A (SEMA3A) in BMSCs. To better understand the role of VEGFA and SEMA3A in leukemogenesis, we recruited 30 myelodysplastic syndrome (MDS) patients, 29 acute myeloid leukemia (6 secondary to MDS) patients and 12 controls...
June 3, 2017: Stem Cell Research
https://www.readbyqxmd.com/read/28625360/hypoxia-primed-placental-mesenchymal-stem-cells-for-wound-healing
#2
Suja Ann Mathew, Bhawna Chandravanshi, Ramesh Bhonde
AIMS: To investigate how Placental Mesenchymal Stem Cells (P-MSCs) would adapt themselves and survive under hypoxic conditions which are prevalent in most injury sites. MAIN METHODS: P-MSCs were isolated from term placenta and characterised under normoxia and hypoxia (2-2.5% O2). Cells were examined for morphology and surface marker variations by flow cytometry analysis. Glucose stimulated insulin secretion was assayed by Insulin ELISA Kit. Gene expression levels were estimated using Real Time PCR for hypoxia inducible factor1 alpha, Insulin (INS), Glucose transporters (GLUT-1, GLUT-2 and GLUT-3), Adhesion Proteins- Integrins, Fibronectin1 (FN1), E-Cadherin (CDH1), and N-Cadherin (CDH2) and angiogenesis marker VEGFA...
June 15, 2017: Life Sciences
https://www.readbyqxmd.com/read/28624363/brazilian-red-propolis-effects-on-peritoneal-macrophage-activity-nitric-oxide-cell-viability-pro-inflammatory-cytokines-and-gene-expression
#3
Bruno Bueno-Silva, Dione Kawamoto, Ellen S Ando-Suguimoto, Renato C V Casarin, Severino M Alencar, Pedro L Rosalen, Marcia P A Mayer
ETHNOPHARMACOLOGICAL RELEVANCE: Propolis has been used in folk medicine since ancient times and it presented inhibitory effect on neutrophil recruitment previously. However, its effect on macrophage obtained from mice remains unclear. AIM OF THE STUDY: to demonstrate BRP effects on LPS activated peritoneal macrophage. MATERIALS AND METHODS: Peritoneal macrophages, obtained from C57BL6 mice and activated with LPS, were treated with 50 to 80µg/mL of crude extract of Brazilian red propolis (BRP) during 48hours...
June 14, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28623969/altered-gene-expression-in-human-placenta-after-suspected-preterm-labour
#4
D Oros, M Strunk, P Breton, C Paules, R Benito, E Moreno, M Garcés, J Godino, J Schoorlemmer
INTRODUCTION: Suspected preterm labour occurs in around 9% of pregnancies. However, almost two-thirds of women admitted for threatened preterm labour ultimately deliver at term and are considered risk-free for fetal development. METHODS: We examined placental and umbilical cord blood samples from preterm or term deliveries after threatened preterm labour as well as term deliveries without threatened preterm labour. We quantitatively analysed the mRNA expression of inflammatory markers (IL6, IFNγ, and TNFα) and modulators of angiogenesis (FGF2, PGF, VEGFA, VEGFB, and VEGFR1)...
July 2017: Placenta
https://www.readbyqxmd.com/read/28623423/cxcl10-suppression-of-hem-and-lymph-angiogenesis-in-inflamed-corneas-through-mmp13
#5
Nan Gao, Xiaowei Liu, Jiayin Wu, Juan Li, Chen Dong, Xinyi Wu, Xiao Xiao, Fu-Shin X Yu
Though not present in the normal adult cornea, both hem- and lymph-angiogenesis can be induced in this tissue after an inflammatory, infectious, or traumatic insult. We previously showed that the chemokine CXCL10 plays a key role in eradicating invading Candida (C.) albicans in C57BL6 mouse corneas. However, even after the clearance of pathogens, infection-induced inflammation and angiogenesis continue to progress in the cornea. The aim of this study is define the role of CXCL10 as a major angiostatic factor in modulating cornea angiogenesis in B6 mouse corneas under pathogenic conditions...
June 16, 2017: Angiogenesis
https://www.readbyqxmd.com/read/28622513/comprehensive-and-integrative-genomic-characterization-of-hepatocellular-carcinoma
#6
(no author information available yet)
Liver cancer has the second highest worldwide cancer mortality rate and has limited therapeutic options. We analyzed 363 hepatocellular carcinoma (HCC) cases by whole-exome sequencing and DNA copy number analyses, and we analyzed 196 HCC cases by DNA methylation, RNA, miRNA, and proteomic expression also. DNA sequencing and mutation analysis identified significantly mutated genes, including LZTR1, EEF1A1, SF3B1, and SMARCA4. Significant alterations by mutation or downregulation by hypermethylation in genes likely to result in HCC metabolic reprogramming (ALB, APOB, and CPS1) were observed...
June 15, 2017: Cell
https://www.readbyqxmd.com/read/28620375/comparative-gene-expression-analysis-of-lymphocytes-treated-with-exosomes-derived-from-ovarian-cancer-and-ovarian-cysts
#7
Yujuan Li, Yang Yang, Aiwei Xiong, Xiaoqin Wu, Jingyan Xie, Suping Han, Shuli Zhao
Cancer cells employ many strategies to evade immune defense and to facilitate tumor growth and angiogenesis. As a novel mode of intercellular communication, cancer-derived exosomes contribute to the recruitment and mediation of lymphocytes within the tumor environment. However, the mechanisms and key molecules mediating the effect of exosomes on lymphocytes are unclear. We treated healthy peripheral blood lymphocytes with exosomes from ovarian cancer and ovarian cysts and screened for differentially expressed genes using the RT(2) Profiler Cancer Inflammation and Immunity Crosstalk PCR Array...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28619820/soxf-factors-induce-notch1-expression-via-direct-transcriptional-regulation-during-early-arterial-development
#8
Ivy Kim-Ni Chiang, Martin Fritzsche, Cathy Pichol-Thievend, Alice Neal, Kelly Holmes, Anne Lagendijk, Jeroen Overman, Donatella D'Angelo, Alice Omini, Dorien Hermkens, Emmanuelle Lesieur, Ke Liu, Indrika Ratnayaka, Monica Corada, George Bou-Gharios, Jason Carroll, Elisabetta Dejana, Stefan Schulte-Merker, Benjamin Hogan, Monica Beltrame, Sarah De Val, Mathias Francois
Arterial specification and differentiation are influenced by a number of regulatory pathways. While it is known that the Vegfa-Notch cascade plays a central role in this biological process, the transcriptional hierarchy controlling arterial specification has not been fully delineated. To elucidate the direct transcriptional regulators of Notch receptor expression in arterial endothelial cells, we used histone signatures, DNaseI hypersensitivity and ChIP-seq data to identify enhancers for the human NOTCH1 and zebrafish notch1b genes...
June 15, 2017: Development
https://www.readbyqxmd.com/read/28616206/a-systematic-review-and-meta-analysis-of-genetic-association-studies-for-the-role-of-inflammation-and-the-immune-system-in-diabetic-nephropathy
#9
Maria Tziastoudi, Ioannis Stefanidis, Georgios M Hadjigeorgiou, Konstantinos Stravodimos, Elias Zintzaras
Background: Despite the certain contribution of metabolic and haemodynamic factors in diabetic nephropathy (DN), many lines of evidence highlight the role of immunologic and inflammatory mechanisms. To elucidate the contribution of the immune system in the development of DN, we explored the contribution of gene variants (polymorphisms) in relevant pathophysiologic pathways. Methods: We selected six major pathways related to immune response from the Kyoto Encyclopaedia of Genes and Genomes database and thereafter we traced all available genetic association studies (GASs) involving gene variants in these pathways from PubMed and HuGE Navigator...
June 2017: Clinical Kidney Journal
https://www.readbyqxmd.com/read/28602865/anti-angiogenic-activity-of-water-extract-from-euphorbia-pekinensis-rupr
#10
Wenting Zhang, Bin Liu, Yaru Feng, Jie Liu, Zhiqiang Ma, Jian Zheng, Qing Xia, Yuanyuan Ni, Farong Li, Ruichao Lin
ETHNOPHARMACOLOGICAL RELEVANCE: Euphorbia pekinensis Rupr. (EP) is a Euphorbia species of Euphorbiaceae, which is widely used in traditional Chinese medicine. It has been reported to exhibit therapeutic effects on solid tumors, leukemias, and malignant ascites although underlying molecular mechanisms are poorly delineated. Anti-angiogenic therapy is a recognized strategy for treating cancer-based solid tumors, and is also associated with malignant ascites treatment. STUDY AIM: To study the anti-angiogenic properties of the water extract of EP vinegar preparation (WEVEP)...
June 7, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28601638/the-anti-growth-and-anti-metastasis-effects-of-schisandrin-b-on-hepatocarcinoma-cells-in-vitro-and-in-vivo
#11
Ruijie Sun, Ruiren Zhai, Changlin Ma, Miao Wei
Hepatocarcinoma (HCC) is the most common liver cancer with high metastasis and recurrence rate which represents extremely poor prognosis. In this study, we aimed to investigate the effects of Schisandrin B (Sch B) on HCC cells both in vitro and in vivo and to explore its underlying mechanism. We found that Sch B inhibited the proliferation of HCC cells in a dose-dependent manner as assessed by CCK-8 assay. The flow cytometric assay showed that Sch B significantly induced HCC cell apoptosis. Besides, Sch B suppressed HCC cell metastasis as detected by both wound-healing assay and transwell migration assay...
June 7, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28597396/trpv4-activation-contributes-functional-recovery-from-ischemic-stroke-via-angiogenesis-and-neurogenesis
#12
Chun-Kai Chen, Po-Yuan Hsu, Tzu-Ming Wang, Zhi-Feng Miao, Ruey-Tay Lin, Suh-Hang H Juo
The endothelial transient receptor potential cation channel subfamily V member 4 (TRPV4) plays a crucial role in vascular remodeling; however, TRPV4-mediated angiogenesis after ischemic neuronal death as a neurorestorative strategy has not yet been thoroughly examined. In this study, we first tested whether TRPV4 activation can improve functional recovery in rats subjected to transient brain ischemia. The possible mechanisms for TRPV4 activation-promoted functional recovery were explored. A TRPV4 agonist, 4α-phorbol 12,13-didecanoate (4α-PDD), was intravenously injected via the tail vein at 6 h and 1, 2, 3, 4 days after ischemic stroke...
June 9, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28591612/role-of-ambient-gas-composition-on-cold-physical-plasma-elicited-cell-signaling-in-keratinocytes
#13
Anke Schmidt, Sander Bekeschus, Helena Jablonowski, Annemarie Barton, Klaus-Dieter Weltmann, Kristian Wende
A particularly promising medical application of cold physical plasma is the support of wound healing. This is presumably achieved by modulating inflammation as well as skin cell signaling and migration. Plasma-derived reactive oxygen and nitrogen species (ROS/RNS) are assumed the central biologically active plasma components. We hypothesized that modulating the environmental plasma conditions from pure nitrogen (N2) to pure oxygen (O2) in an atmospheric pressure argon plasma jet (kINPen) will change type and concentration of ROS/RNS and effectively tune the behavior of human skin cells...
June 6, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28589712/inhibition-of-angiogenesis-impairs-bone-healing-in-an-in-vivo-murine-rapid-resynostosis-model
#14
Sharon L Hyzy, Illya Kajan, D Scott Wilson, Kelsey A Lawrence, Devon Mason, Joseph K Williams, Rene Olivares-Navarrete, David J Cohen, Zvi Schwartz, Barbara D Boyan
Biologics can improve bone formation, but may diffuse away from sites of therapeutic need. We developed a click-chemistry hydrogel that rapidly polymerizes in situ to control delivery of biologics during post-suturectomy resynostosis in 21-d-old male mice. Here, we used this model to determine the role of angiogenesis in post-suturectomy resynostosis and examine whether controlled release of angiogenesis inhibitors could delay bone regeneration. Hydrogels [DB-co-PEG/poly(TEGDMA)-co-(N3-TEGDMA)] were produced containing anti-angiogenic compounds (anti-VEGFA-antibody or HIF1α-inhibitor topotecan)...
June 7, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28588740/microrna-497-overexpression-decreases-proliferation-migration-and-invasion-of-human-retinoblastoma-cells-via-targeting-vascular-endothelial-growth-factor-a
#15
Jianjun Li, Yinghui Zhang, Xiuchao Wang, Ruibo Zhao
The expression level and roles of microRNA-497 (miR-497) have been frequently reported in previous studies on cancer. However, its expression, function and associated molecular mechanisms in retinoblastoma remain unknown. In the present study, miR-497 expression levels in human retinoblastoma tissues, normal retinal tissues and retinoblastoma cell lines were determined using reverse transcription-quantitative polymerase chain reaction. In addition, a Cell Counting Kit-8 assay, cell migration assay, cell invasion assay, western blot analysis and Dual-Luciferase reporter assay were used to explore the expression, functions and molecular mechanisms of miR-497 in human retinoblastoma...
June 2017: Oncology Letters
https://www.readbyqxmd.com/read/28587437/overexpression-and-correlation-of-hif-2%C3%AE-vegfa-and-epha2-in-residual-hepatocellular-carcinoma-following-high-intensity-focused-ultrasound-treatment-implications-for-tumor-recurrence-and-progression
#16
Lun Wu, You-Shun Zhang, Meng-Liang Ye, Feng Shen, Wei Liu, Hong-Sheng Hu, Sheng-Wei Li, Hong-Wei Wu, Qin-Hua Chen, Wen-Bo Zhou
Rapid growth of residual tumors can occur as a result of their recurrence and progression. The present study aimed to investigate the expression of hypoxia inducible factor-2 subunit α (HIF-2α), vascular endothelial growth factor A (VEGFA), erythropoietin-producing hepatocellular A2 (EphA2) and angiogenesis in residual hepatocellular carcinoma (HCC), following treatment with high-intensity focused ultrasound (HIFU) ablation, in order to investigate the association between protein expression and tumor recurrence and growth...
June 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28586059/identification-of-critical-genes-in-nucleus-pulposus-cells-isolated-from-degenerated-intervertebral-discs-using-bioinformatics-analysis
#17
Zhuangchen Zhu, Guang Chen, Wei Jiao, Defeng Wang, Yan Cao, Qingfu Zhang, Junqin Wang
Intervertebral disc (IVD) degeneration is a pathological process, which may lead to lower back pain. The present study aimed to investigate the pathogenesis of IVD degeneration. GSE42611 was downloaded from Gene Expression Omnibus, including 4 nucleus pulposus samples isolated from degenerated IVDs and 4 nucleus pulposus samples separated from normal IVDs. The differentially expressed genes (DEGs) between the degenerated and normal samples were screened using the limma package in R. Functional and pathway enrichment analyses were conducted separately for the upregulated and downregulated genes, using Database for Annotation, Visualization and Integrated Discovery software...
July 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28584091/dissecting-bmp-signaling-input-into-the-gene-regulatory-networks-driving-specification-of-the-blood-stem-cell-lineage
#18
Arif Kirmizitas, Stuart Meiklejohn, Aldo Ciau-Uitz, Rachel Stephenson, Roger Patient
Hematopoietic stem cells (HSCs) that sustain lifelong blood production are created during embryogenesis. They emerge from a specialized endothelial population, termed hemogenic endothelium (HE), located in the ventral wall of the dorsal aorta (DA). In Xenopus, we have been studying the gene regulatory networks (GRNs) required for the formation of HSCs, and critically found that the hemogenic potential is defined at an earlier time point when precursors to the DA express hematopoietic as well as endothelial genes, in the definitive hemangioblasts (DHs)...
June 6, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28581513/kif26b-a-novel-oncogene-promotes-proliferation-and-metastasis-by-activating-the-vegf-pathway-in-gastric-cancer
#19
H Zhang, R-R Ma, X-J Wang, Z-X Su, X Chen, D-B Shi, X-Y Guo, H-T Liu, P Gao
Tumor metastasis is the main reason of cancer-related death for gastric cancer (GC) patients and gene expression microarray data indicate that kinesin family member 26B (KIF26B) is one of the most upregulated genes in metastatic GC samples. Specifically, KIF26B expression was upregulated in a stepwise manner from non-tumorous gastric mucosa, primary GC tissues without metastasis, via primary GC tissues with metastasis, to secondary lymph node metastatic (LNM) foci. Increased expression of KIF26B was correlated with tumor size, positive LNM or distant metastases and poor prognosis...
June 5, 2017: Oncogene
https://www.readbyqxmd.com/read/28581123/astrocyte-derived-lipocalin-2-mediates-hippocampal-damage-and-cognitive-deficits-in-experimental-models-of-vascular-dementia
#20
Jae-Hong Kim, Pan-Woo Ko, Ho-Won Lee, Ji-Young Jeong, Maan-Gee Lee, Jong-Heon Kim, Won-Ha Lee, Ri Yu, Won-Jong Oh, Kyoungho Suk
Lipocalin-2 (LCN2) has diverse functions in multiple pathophysiological conditions; however, its pathogenic role in vascular dementia (VaD) is unknown. Here, we investigated the role of LCN2 in VaD using rodent models of global cerebral ischemia and hypoperfusion with cognitive impairment and neuroinflammation. Mice subjected to transient bilateral common carotid artery occlusion (tBCCAo) for 50 min showed neuronal death and gliosis in the hippocampus at 7 days post-tBCCAo. LCN2 expression was observed predominantly in the hippocampal astrocytes, whereas its receptor was mainly detected in neurons, microglia, and astrocytes...
June 5, 2017: Glia
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