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https://www.readbyqxmd.com/read/27802033/an-azobenzenyl-anion-radical-complex-of-magnesium-synthesis-structure-and-reactivity-studies
#1
Wenshan Ren, Defa Gu
Azobenzenyl anion radical complex of magnesium [HC(C(Me)N-2,6-(i)Pr2C6H3)2]Mg(PhNNPh) (THF) (2) was obtained for the first time through the reaction of [HC(C(Me)N-2,6-(i)Pr2C6H3)2]MgBr (1) with potassium graphite in the presence of azobenzene. Complex 2 is a useful electron-transfer reagent as shown by the reactivity with diphenyl disulfide, diphenyl diselenide, oxygen, sulfur, and Me3SiN3 yielding the magnesium thiolate [HC(C(Me)N-2,6-(i)Pr2C6H3)2]Mg(SPh)(THF) (3), magnesium selenolate [HC(C(Me)N-2,6-(i)Pr2C6H3)2]Mg(SePh)(THF) (4), peroxido complex {[HC(C(Me)N-2,6-(i)Pr2C6H3)2]Mg(THF)}2(μ-η(2)-η(2)-O2) (5), persulfido complex {[HC(C(Me)N-2,6-(i)Pr2C6H3)2]Mg(THF)}2(μ-η(2)-η(2)-S2) (6), and azido complex [HC(C(Me)N-2,6-(i)Pr2C6H3)2]MgN3 (7), respectively...
November 1, 2016: Inorganic Chemistry
https://www.readbyqxmd.com/read/27752660/co-tolerance-of-pt-feox-catalyst-in-both-thermal-catalytic-h2-oxidation-and-electrochemical-co-oxidation-the-effect-of-pt-deficit-electron-state
#2
Lequan Liu, Feng Zhou, Rajesh Kodiyath, Shigenori Ueda, Hideki Abe, Defa Wang, Youquan Deng, Jinhua Ye
CO poisoning of Pt catalysts is one of the major challenges to the commercialization of proton exchange membrane fuel cells. One promising solution is to develop CO-tolerant Pt-based catalysts. A facilely synthesized Pt/FeOx catalyst exhibited outstanding CO tolerance in the oxidation of H2 and electrochemical CO stripping. Light-off temperature of H2O formation over Pt/FeOx was achieved even below 30 °C in the presence of 3000 ppm CO at a space velocity of 18 000 mL g(-1)cat h(-1). For the electrochemical oxidation of CO, the onset and peak potentials decreased by 0...
October 18, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27660021/evaluation-of-available-energy-and-total-tract-digestibility-of-acid-hydrolyzed-ether-extract-in-cottonseed-oil-for-growing-pigs
#3
Jinbiao Zhao, Zhongchao Li, Mingbin Lyu, Ling Liu, Xiangshu Piao, Defa Li
The objective of this study was to determine the effect of inclusion level on the digestible energy (DE), metabolizable energy (ME) and total tract digestibility of acid-hydrolyzed ether extract (AEE) for cottonseed oil when fed to growing pigs. Forty-two barrows (initial BW = 35.51 ± 2.01 kg) were randomly allotted to a completely randomized design with a corn-soybean meal basal diet, five levels of cottonseed oil (2%, 4%, 6%, 8% and 10%) and a 10% soybean oil diet. Each diet was replicated six times with one pig per replicate...
September 19, 2016: Asian-Australasian Journal of Animal Sciences
https://www.readbyqxmd.com/read/27611633/effects-of-variety-and-storage-duration-on-the-nutrient-digestibility-and-the-digestible-and-metabolisable-energy-content-of-maize-fed-to-growing-pigs
#4
Lei Zhang, Ling Liu, Defa Li, Quanfeng Li, Xiangshu Piao, Philip A Thacker, Michael A Brown, Changhua Lai
The objective of this research was to determine the effects of variety and storage duration on the nutrient digestibility and the digestible (DE) and metabolisable (ME) energy content in maize when fed to growing pigs. Four maize varieties (LS1, LS2, LS3 and LS4) were hand-harvested from the same growing area in China in early October of 2012. The samples were sun dried to about 14% moisture content and then stored in the warehouse of the Fengning Pig Experiment Base at China Agricultural University for 0, 3 or 10 months...
September 9, 2016: Archives of Animal Nutrition
https://www.readbyqxmd.com/read/27598177/design-and-synthesis-of-analogues-of-marine-natural-product-galaxamide-an-n-methylated-cyclic-pentapeptide-as-potential-anti-tumor-agent-in-vitro
#5
Jignesh Lunagariya, Shenghui Zhong, Jianwei Chen, Defa Bai, Poonam Bhadja, Weili Long, Xiaojian Liao, Xiaoli Tang, Shihai Xu
Herein, we report design and synthesis of novel 26 galaxamide analogues with N-methylated cyclo-pentapeptide, and their in vitro anti-tumor activity towards the panel of human tumor cell line, such as, A549, A549/DPP, HepG2 and SMMC-7721 using MTT assay. We have also investigated the effect of galaxamide and its representative analogues on growth, cell-cycle phases, and induction of apoptosis in SMMC-7721 cells in vitro. Reckon with the significance of conformational space and N-Me aminoacid (aa) comprising this compound template, we designed the analogues with modification in N-Me-aa position, change in aa configuration from l to d aa and substitute one Leu-aa to d/l Phe-aa residue with respective to the parent structure...
September 3, 2016: Marine Drugs
https://www.readbyqxmd.com/read/27563435/erratum-to-use-of-near-infrared-reflectance-spectroscopy-for-the-rapid-determination-of-the-digestible-energy-and-metabolizable-energy-content-of-corn-fed-to-growing-pigs
#6
Juntao Li, Quanfeng Li, Defa Li, Yiqiang Chen, Xiaoxiao Wang, Wenjun Yang, Liying Zhang
[This corrects the article DOI: 10.1186/s40104-016-0105-9.].
2016: Journal of Animal Science and Biotechnology
https://www.readbyqxmd.com/read/27563166/elevated-plasma-%C3%AE-defensins-hnp1-3-levels-correlated-with-iga1-glycosylation-and-susceptibility-to-iga-nephropathy
#7
Yuan-Yuan Qi, Xu-Jie Zhou, Fa-Juan Cheng, Hong Zhang
Aim. IgA nephropathy (IgAN) is the most common form of glomerulonephritis. Recent genome-wide association study (GWAS) suggested that DEFA locus (which encodes α-defensins) may play a key role in IgAN. Methods. The levels of α-defensins in 169 IgAN patients and 83 healthy controls were tested by ELISA. Results. We observed that α-defensins human neutrophil peptides 1-3 (HNP1-3) in IgAN patients were elevated compared with healthy controls. The mean levels of α-defensins of 83 healthy controls and 169 IgAN patients were 50 ng/mL and 78...
2016: Disease Markers
https://www.readbyqxmd.com/read/27514477/acetylcholine-producing-t-cells-in-the-intestine-affect-antimicrobial-peptide-expression-and-microbial-diversity
#8
Shobhit Dhawan, Giada De Palma, Rose A Willemze, Francisca Hilbers, Caroline Verseijden, Misha Luyer, Sabine Nuding, Jan Wehkamp, Yuri Souwer, Esther C de Jong, Jurgen Seppen, Rene Mjgj van den Wijngaard, Sven Wehner, Elena F Verdu, Premysl Bercik, Wouter J de Jonge
The cholinergic anti-inflammatory pathway reduces systemic TNF via acetylcholine producing memory T-cells in the spleen. These choline acetyltransferase (ChAT) expressing T-cells are also found in the intestine, where their function is unclear. We aimed to characterize these cells in mouse and human intestine and delineate their function. We made use of the ChAT-eGFP reporter mice. CD4Cre mice were crossed to ChATfl/fl mice to achieve specific deletion of ChAT in CD4+ T-cells. We observed that the majority of ChAT expressing T-cells in the human and mouse intestine have characteristics of Th17 cells, and co-express IL17A, IL22 and RORC...
August 11, 2016: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/27505316/influence-of-pachymetry-and-intraocular-pressure-on-dynamic-corneal-response-parameters-in-healthy-patients
#9
Riccardo Vinciguerra, Ahmed Elsheikh, Cynthia J Roberts, Renato Ambrósio, David Sung Yong Kang, Bernardo T Lopes, Emanuela Morenghi, Claudio Azzolini, Paolo Vinciguerra
PURPOSE: To evaluate the influence of pachymetry, age, and intraocular pressure in normal patients and to provide normative values for all dynamic corneal response parameters (DCRs) provided by dynamic Scheimpflug analysis. METHODS: Seven hundred five healthy patients were included in this multicenter retrospective study. The biomechanical response data were analyzed to obtain normative values with their dependence on corrected and clinically validated intraocular pressure estimates developed using the finite element method (bIOP), central corneal thickness (CCT), and age, and to evaluate the influence of bIOP, CCT, and age...
August 1, 2016: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/27493726/use-of-near-infrared-reflectance-spectroscopy-for-the-rapid-determination-of-the-digestible-energy-and-metabolizable-energy-content-of-corn-fed-to-growing-pigs
#10
Juntao Li, Quanfeng Li, Defa Li, Yiqiang Chen, Xiaoxiao Wang, Wunjun Yang, Liying Zhang
BACKGROUND: The ability of near-infrared reflectance spectroscopy (NIRS) to determine the digestible energy (DE) and metabolizable energy (ME) content of corn fed to growing pigs was tested. One hundred and seventeen corn samples, comprising different planting regions and varieties were collected from all over China in a three-year period. The samples were randomly split into a calibration set (n = 88) and a validation set (n = 29). The actual and calculated DE and ME content of the corn samples was determined by digestion-metabolism experiments and the prediction equations of Noblet and Perez (J Anim Sci...
2016: Journal of Animal Science and Biotechnology
https://www.readbyqxmd.com/read/27469890/aspergillus-fumigatus-spore-proteomics-and-genetics-reveal-that-vea-represses-defa-mediated-dna-damage-response
#11
Kwang-Soo Shin, Hee-Soo Park, Young Kim, In-Beom Heo, Young Hwan Kim, Jae-Hyuk Yu
Aspergillus fumigatus reproduces and infects host by forming a high number of small asexual spores (conidia). The velvet proteins are global transcriptional regulators governing the complex process of conidiogenesis in this fungus. Here, to further understand the velvet-mediated regulation, we carried out comparative proteomic analyses of conidia of wild type (WT) and three velvet mutants (ΔveA, ΔvelB and ΔvosA). Cluster analysis of 184 protein spots showing at least 1.5-fold differential accumulation between WT and mutants reveal the clustering of WT- ΔveA and ΔvelB-ΔvosA...
October 4, 2016: Journal of Proteomics
https://www.readbyqxmd.com/read/27464458/effects-of-isoleucine-on-glucose-uptake-through-the-enhancement-of-muscular-membrane-concentrations-of-glut1-and-glut4-and-intestinal-membrane-concentrations-of-na-glucose-co-transporter-1-sglt-1-and-glut2
#12
Shihai Zhang, Qing Yang, Man Ren, Shiyan Qiao, Pingli He, Defa Li, Xiangfang Zeng
Knowledge of regulation of glucose transport contributes to our understanding of whole-body glucose homoeostasis and human metabolic diseases. Isoleucine has been reported to participate in regulation of glucose levels in many studies; therefore, this study was designed to examine the effect of isoleucine on intestinal and muscular GLUT expressions. In an animal experiment, muscular GLUT and intestinal GLUT were determined in weaning pigs fed control or isoleucine-supplemented diets. Supplementation of isoleucine in the diet significantly increased piglet average daily gain, enhanced GLUT1 expression in red muscle and GLUT4 expression in red muscle, white muscle and intermediate muscle (P<0·05)...
August 2016: British Journal of Nutrition
https://www.readbyqxmd.com/read/27447724/development-of-novel-erythromycin-derivatives-with-inhibitory-activity-against-proliferation-of-tumor-cells
#13
Lan Wu, Kai Bao, Rui Song, Defa Wang, Lei Zhang, Weiyun Wang, Weige Zhang, Wen Bin
In our continuing structure-activity relationship study of a new class of erythromycin A (EM-A) derivatives with antiproliferative activity, a new series of de(N-methyl) EM-A dimers jointed by a four-atom linker, -CH2CH = CHCH2-, were prepared and their antiproliferative activity against three human tumor cell lines was evaluated by MTT assay. The most active EM-A dimer, compound 1b, that carrying C6 methoxyl groups was further investigated and showed potent antiproliferative activity in six other human tumor cell lines...
2016: PloS One
https://www.readbyqxmd.com/read/27400025/evaluation-of-validity-of-the-new-diabetic-foot-ulcer-assessment-scale-in-indonesia
#14
Defa Arisandi, Makoto Oe, Rie Roselyne Yotsu, Masaru Matsumoto, Kazuhiro Ogai, Gojiro Nakagami, Takeshi Tamaki, Suriadi, Hiromi Sanada, Junko Sugama
We developed a new assessment tool for diabetic foot ulcers because no such tool specifically for diabetic foot ulcer exists. The diabetic foot ulcer assessment scale (DFUAS) has 11 domain items. The minimum and maximum scores on this scale are 0 and 98, respectively; higher scores indicate more severe wounds. The aim of this study was to evaluate the concurrent validity, construct validity and predictive validity of DFUAS in Indonesia. A prospective cohort study was conducted on patients with diabetic foot ulcer at Kitamura wound clinic in Indonesia...
July 11, 2016: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/27397143/relationship-between-maceration-and-wound-healing-on-diabetic-foot-ulcers-in-indonesia-a-prospective-study
#15
Haryanto Haryanto, Defa Arisandi, Suriadi Suriadi, Imran Imran, Kazuhiro Ogai, Hiromi Sanada, Mayumi Okuwa, Junko Sugama
The aim of this study was to clarify the relationship between maceration and wound healing. A prospective longitudinal design was used in this study. The wound condition determined the type of dressings used and the dressing change frequency. A total of 62 participants with diabetic foot ulcers (70 wounds) were divided into two groups: non-macerated (n = 52) and macerated wounds (n = 18). Each group was evaluated weekly using the Bates-Jensen Wound Assessment Tool, with follow-ups until week 4. The Mann-Whitney U test showed that the changes in the wound area in week 1 were faster in the non-macerated group than the macerated group (P = 0·02)...
July 10, 2016: International Wound Journal
https://www.readbyqxmd.com/read/27376684/topological-edge-states-in-a-high-temperature-superconductor-fese-srtio3-001-film
#16
Z F Wang, Huimin Zhang, Defa Liu, Chong Liu, Chenjia Tang, Canli Song, Yong Zhong, Junping Peng, Fangsen Li, Caina Nie, Lili Wang, X J Zhou, Xucun Ma, Q K Xue, Feng Liu
Superconducting and topological states are two most intriguing quantum phenomena in solid materials. The entanglement of these two states, the topological superconducting state, will give rise to even more exotic quantum phenomena. While many materials are found to be either a superconductor or a topological insulator, it is very rare that both states exist in one material. Here, we demonstrate by first-principles theory as well as scanning tunnelling spectroscopy and angle-resolved photoemission spectroscopy experiments that the recently discovered 'two-dimensional (2D) superconductor' of single-layer FeSe also exhibits 1D topological edge states within an energy gap of ∼40 meV at the M point below the Fermi level...
September 2016: Nature Materials
https://www.readbyqxmd.com/read/27356939/the-mechanism-of-l-arginine-modulates-signal-proteins-involved-in-glucose-and-lipid-metabolic-imbalance
#17
Shengdi Hu, Meng Han, Arash Rezaei, Defa Li, W Guoyao, Xi Ma
Type 2 diabetes has become a global public health problem affecting approximately 380 million people throughout the world. It can cause many complications and lead to greater mortality. At present, there is no available medicine for effectively preventing diabetes. L-arginine, a functional amino acid, the precursor of nitric oxide, plays a crucial role in maintenance, reproduction, growth, anti-aging and immunity in animals. Growing clinical evidence indicates that dietary L-arginine supplementation can reduce obesity, decrease arterial blood pressure, resist oxidation and normalize endothelial dysfunction to cause remission of type 2 diabetes...
June 26, 2016: Current Protein & Peptide Science
https://www.readbyqxmd.com/read/27317510/effects-of-ctr4-deletion-on-virulence-and-stress-response-in-cryptococcus-neoformans
#18
Ping Zhang, Defa Zhang, Xueru Zhao, Dongsheng Wei, Yu Wang, Xudong Zhu
Roles of the high-affinity copper transporter Ctr4 in the virulence of Cryptococcus neoformans remain to be fully determined. Here we demonstrate that Ctr4 plays a necessary role in virulence and tolerance to a number of stress conditions. We first observed, with the method of flame atomic absorption spectrometry, that deletion of CTR4 resulted in a significant decrease in intracellular copper level, confirming the role of Ctr4 as a copper transporter in C. neoformans. Furthermore, CTR4 was critical for the yeast to survive at both elevated and low temperatures, as the growth rate of the ctr4Δ mutant at 4 and 37 °C was significantly decreased...
August 2016: Antonie Van Leeuwenhoek
https://www.readbyqxmd.com/read/27226197/the-signal-pathway-of-antibiotic-alternatives-on-intestinal-microbiota-and-immune-function
#19
Ji Wang, Meng Han, Guolong Zhang, Shiyan Qiao, Defa Li, Xi Ma
Antibiotics are one of the most important discoveries in the 20th century and have been widely used for treating animal diseases in the 21st century. However, antibiotic resistance among bacterial pathogens and widespread concerns regarding their use in animals has received great attention all over the world. Great attention has focused on scientific breakthroughs of the alternatives to antibiotics. Various materials such as enzymes, prebiotics, probiotics, minerals, antimicrobial peptides, acidifiers, plants and plant extracts have been tested as possible antibiotics alternatives...
May 26, 2016: Current Protein & Peptide Science
https://www.readbyqxmd.com/read/27185493/nanometals-for-solar-to-chemical-energy-conversion-from-semiconductor-based-photocatalysis-to-plasmon-mediated-photocatalysis-and-photo-thermocatalysis
#20
Xianguang Meng, Lequan Liu, Shuxin Ouyang, Hua Xu, Defa Wang, Naiqin Zhao, Jinhua Ye
Nanometal materials play very important roles in solar-to-chemical energy conversion due to their unique catalytic and optical characteristics. They have found wide applications from semiconductor photocatalysis to rapidly growing surface plasmon-mediated heterogeneous catalysis. The recent research achievements of nanometals are reviewed here, with regard to applications in semiconductor photocatalysis, plasmonic photocatalysis, and plasmonic photo-thermocatalysis. As the first important topic discussed here, the latest progress in the design of nanometal cocatalysts and their applications in semiconductor photocatalysis are introduced...
August 2016: Advanced Materials
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