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https://www.readbyqxmd.com/read/29455030/the-clinical-significance-and-biological-function-of-tropomyosin-4-in-colon-cancer
#1
Rui Yang, Gang Zheng, Defa Ren, Chunzhou Chen, Cheng Zeng, Wei Lu, Hua Li
Tropomyosin 4 (TPM4) has been found to be dys-regulated, and function as oncogene or anti-oncogene in human cancers. However, there was no report on the clinical significance and biological function of TPM4 in colon cancer. This study was designed to investigate the clinical value and biological function of TPM4 in colon cancer. Thus, we detected the TPM4 expression in colon cancer clinical samples, and conducted the gain-of-function in colon cancer cell lines. In our results, TPM4 mRNA and protein expressions were reduced in colon cancer tissues and cell lines compared with normal colon tissues and colon epithelial cell line, respectively...
February 15, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29438462/butyrate-a-double-edged-sword-for-health
#2
Hu Liu, Ji Wang, Ting He, Sage Becker, Guolong Zhang, Defa Li, Xi Ma
Butyrate, a four-carbon short-chain fatty acid, is produced through microbial fermentation of dietary fibers in the lower intestinal tract. Endogenous butyrate production, delivery, and absorption by colonocytes have been well documented. Butyrate exerts its functions by acting as a histone deacetylase (HDAC) inhibitor or signaling through several G protein-coupled receptors (GPCRs). Recently, butyrate has received particular attention for its beneficial effects on intestinal homeostasis and energy metabolism...
January 1, 2018: Advances in Nutrition
https://www.readbyqxmd.com/read/29381902/additivity-of-values-for-phosphorus-digestibility-in-corn-soybean-meal-and-canola-meal-in-diets-fed-to-growing-pigs
#3
Yue She, Qiuyun Wang, Hans H Stein, Ling Liu, Defa Li, Shuai Zhang
Objective: This study was conducted to determine the apparent and standardized total tract digestibility (ATTD and STTD) of phosphorus (P) in corn, soybean meal (SBM), and canola meal (CM), and additivity of values for ATTD and STTD of P in corn, SBM, and CM in diets fed to growing pigs. Methods: Thirty-six growing barrows (initial BW of 21.6 ± 1.7 kg) were placed in metabolism crates and allotted to a completely randomized design with 6 diets and 6 pigs per diet...
January 26, 2018: Asian-Australasian Journal of Animal Sciences
https://www.readbyqxmd.com/read/29241453/bile-acid-is-a-significant-host-factor-shaping-the-gut-microbiome-of-diet-induced-obese-mice
#4
Xiaojiao Zheng, Fengjie Huang, Aihua Zhao, Sha Lei, Yunjing Zhang, Guoxiang Xie, Tianlu Chen, Chun Qu, Cynthia Rajani, Bing Dong, Defa Li, Wei Jia
BACKGROUND: Intestinal bacteria are known to regulate bile acid (BA) homeostasis via intestinal biotransformation of BAs and stimulation of the expression of fibroblast growth factor 19 through intestinal nuclear farnesoid X receptor (FXR). On the other hand, BAs directly regulate the gut microbiota with their strong antimicrobial activities. It remains unclear, however, how mammalian BAs cross-talk with gut microbiome and shape microbial composition in a dynamic and interactive way. RESULTS: We quantitatively profiled small molecule metabolites derived from host-microbial co-metabolism in mice, demonstrating that BAs were the most significant factor correlated with microbial alterations among all types of endogenous metabolites...
December 14, 2017: BMC Biology
https://www.readbyqxmd.com/read/29227513/in-vivo-early-corneal-biomechanical-changes-after-corneal-cross-linking-in-patients-with-progressive-keratoconus
#5
Riccardo Vinciguerra, Vito Romano, Esmaeil M Arbabi, Matthias Brunner, Colin E Willoughby, Mark Batterbury, Stephen B Kaye
PURPOSE: To report early corneal biomechanical changes after corneal cross-linking (CXL) in patients with keratoconus. METHODS: Thirty-four eyes of 34 patients undergoing CXL for progressive keratoconus were included in this prospective clinical study. Dynamic corneal response (DCR) parameters obtained with the Corvis ST (OCULUS Optikgeräte GmbH; Wetzlar, Germany) were assessed at baseline (day of CXL) and after 1 month of follow-up; conversely, corneal tomography with the Pentacam (OCULUS Optikgeräte GmbH) was assessed at baseline and at 1, 3, and 6 months after CXL...
December 1, 2017: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/29131455/effects-of-supplementary-amino-acids-on-available-energy-of-soybean-meal-determined-by-difference-and-regression-methods-fed-to-growing-pigs
#6
Jinbiao Zhao, Chuanxin Shi, Zhongchao Li, Ji Wang, Ling Liu, Defa Li, Shuai Zhang
This study was conducted to evaluate effects of inclusion level and supplementary amino acids (AAs) on digestible energy (DE) and metabolizable energy (ME) values of soybean meal (SBM) fed to growing pigs, determined by difference and regression methods. Sixty pigs were fed 10 diets according to a 5 × 2 factorial arrangement. Two control diets contained 97.34% corn without supplementary AAs or 95.61% corn with supplementary AAs. Eight diets were formulated by replacing corn and AAs in control diets with 8%, 15%, 25% and 31% SBM...
November 12, 2017: Animal Science Journal, Nihon Chikusan Gakkaihō
https://www.readbyqxmd.com/read/28968775/transcription-profiling-for-defensins-of-aedes-aegypti-diptera-culicidae-during-development-and-in-response-to-infection-with-chikungunya-and-zika-viruses
#7
Liming Zhao, Barry W Alto, Chelsea T Smartt, Dongyoung Shin
Aedes aegypti (L.) is a vector of chikungunya, dengue, yellow fever and Zika viruses. These viruses encounter a variety of induced defense responses from the innate immune system of the mosquito. We cloned defensin A from Ae. aegypti using laboratory populations originating from Key West and Orlando, Florida. To characterize inducible immune defensin peptides, we examined the defensin A (DefA) and defensin C (DefC) expression through time course studies using quantitative real-time PCR. We observed that ingestion of chikungunya virus (CHIKV) and Zika virus (ZIKV) infected blood triggered early upregulated expression of DefA and DefC at 3 h after blood feeding...
September 6, 2017: Journal of Medical Entomology
https://www.readbyqxmd.com/read/28920415/effects-of-pig-breed-on-nutrient-and-amino-acid-digestibility-in-diets-with-different-fiber-sources
#8
Jinbiao Zhao, Qiuyun Wang, Ling Liu, Yiqiang Chen, Aiming Jin, Guoliang Liu, Kaizhen Li, Defa Li, Changhua Lai
Objective: This experiment was conducted to determine the differences in the apparent ileal (AID) and total tract digestibility (ATTD) of nutrient and indispensable amino acid (IAA) in high-fiber diets with wheat middlings, rice bran or alfalfa meal fed to Duroc x Landrace x Yorkshire (DLY) and Duroc x Berkshire x Jiaxing (DBJ) growing pigs. Methods: Eighteen DLY and 18 DBJ pigs were randomly allotted to a 2 x 3 factorial arrangement involving 2 pig breeds and 3 high-fiber diets...
September 18, 2017: Asian-Australasian Journal of Animal Sciences
https://www.readbyqxmd.com/read/28920411/effect-of-inclusion-level-and-adaptation-duration-on-digestible-energy-and-nutrient-digestibility-in-palm-kernel-meal-fed-to-growing-finishing-pigs
#9
Chengfei Huang, Shuai Zhang, Hans-Henrik Stein, Jinbiao Zhao, Defa Li, Changhua Lai
Objective: An experiment was conducted to evaluate effects of inclusion level of palm kernel meal (PKM) and adaptation duration on the digestible energy (DE) and apparent total tract digestibility (ATTD) of chemical constituents in diets fed to growing-finishing pigs. Methods: Thirty crossbred barrows (Duroc × Landrace × Large White) with an average initial body weight (BW) of 85.0 ± 2.1 kg were fed to 5 diets in a completely randomized design. The diets included a corn-soybean meal basal diet and 4 additional diets in which corn and soybean meal (SBM) were partly replaced by 10, 20, 30, or 40% PKM...
September 18, 2017: Asian-Australasian Journal of Animal Sciences
https://www.readbyqxmd.com/read/28914474/determination-of-net-energy-content-of-soybean-oil-fed-to-growing-pigs-using-indirect-calorimetry
#10
Enkai Li, Zhiqian Lv, Hu Liu, Ling Liu, Yakui Li, Zhongchao Li, Fenglai Wang, Defa Li, Shuai Zhang
The objectives of this experiment were: (i) to determine the net energy (NE) of soybean oil (SBO) fed to growing pigs using indirect calorimetry (IC); and (ii) to evaluate the effects of inclusion rate of SBO on heat production, oxidative status and nutrient digestibility in growing pigs. Eighteen growing barrows were allotted to three diets based on completely randomized design with six replicate pigs (period) per diet. Diets included a corn-soybean meal basal diet and two test diets containing 5% or 10% SBO at the expense of corn and soybean meal...
September 15, 2017: Animal Science Journal, Nihon Chikusan Gakkaihō
https://www.readbyqxmd.com/read/28728365/effects-of-inclusion-level-and-adaptation-period-on-nutrient-digestibility-and-digestible-energy-of-wheat-bran-in-growing-finishing-pigs
#11
Jinbiao Zhao, Shuai Zhang, Fei Xie, Defa Li, Chengfei Huang
Objective: This experiment was to evaluate the effect of different inclusion levels and adaptation periods on digestible energy (DE) and the apparent total tract digestibility (ATTD) of chemical constituents in diets supplemented with wheat bran. Methods: Thirty-six crossbred barrows with an initial body weight (BW) of 85.0 ± 2.1 kg were allotted to 6 diets in a completely randomized block design with 6 pigs per diet. Diets included a corn-soybean basal diet and 5 additional diets which formulated by replacing corn and soybean meal in control diet with 15, 25, 35, 45, or 55% wheat bran...
June 27, 2017: Asian-Australasian Journal of Animal Sciences
https://www.readbyqxmd.com/read/28713915/concurrent-administration-of-thyroxine-and-donepezil-induces-plastic-changes-in-the-prefrontal-cortex-of-adult-hypothyroid-rats
#12
Fen Wang, Zhangbi Wu, Xiaoxue Zha, Yaojun Cai, Bo Wu, Xuemei Jia, Defa Zhu
The aim of the present study was to observe the effects of the concurrent administration of thyroxine (T4) and an acetylcholinesterase (AChE) inhibitor, donepezil (DON), on the hypothyroidism‑induced ultrastructural changes of the prefrontal cortex (PFC) in adult rats. The acetylcholine (ACh) content and AChE activity was assessed, as well as the expressions of synaptotagmin‑1 (syt‑1) and SNAP‑25 were analyzed in the rats. Adding 0.05% propylthiouracil to rats' drinking water induced a hypothyroid rat model...
September 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28491297/net-energy-of-corn-soybean-meal-and-rapeseed-meal-in-growing-pigs
#13
Zhongchao Li, Yakui Li, Zhiqian Lv, Hu Liu, Jinbiao Zhao, Jean Noblet, Fenglai Wang, Changhua Lai, Defa Li
BACKGROUND: Two experiments were conducted to estimate the net energy (NE) of corn, soybean meal, expeller-pressed rapeseed meal (EP-RSM) and solvent-extracted rapeseed meal (SE-RSM) using indirect calorimetry and to validate the NE of these four ingredients using pig growth performance. METHODS: In Exp.1, 24 barrows (initial BW = 36.4 ± 1.6 kg) were allotted to 1 of 4 diets which included a corn basal diet, a corn-soybean meal basal diet and two rapeseed meal diets containing 20% EP-RSM (9...
2017: Journal of Animal Science and Biotechnology
https://www.readbyqxmd.com/read/28287429/d-amino-acid-position-influences-the-anticancer-activity-of-galaxamide-analogs-an-apoptotic-mechanism-study
#14
Defa Bai, Siming Yu, Shenghui Zhong, Bingxin Zhao, Shaoling Qiu, Jianwei Chen, Jignesh Lunagariya, Xiaojian Liao, Shihai Xu
Galaxamide, an extract from Galaxaura filamentosa, is a cyclic pentapeptide containing five l-leucines. Due to the particular cyclic structure and the excellent anticancer activity, synthesis of Galaxamide and its analogs and their subsequent bio-applications have attracted great attention. In the present work, we synthesized six Galaxamide analogs by replacing one of the l-leucines with phenylalanine and varying the d-amino acid position. The anticancer effect of the synthesized Galaxamide analogs was tested against four in vitro human cancer cell lines, human hepatocellular cells (HepG₂), human breast cancer cell (MCF-7), human breast adenocarcinoma cells (MDA-MB-435) and a human cervical carcinoma cell line (Hela)...
March 10, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28276486/a-potential-regulatory-network-underlying-distinct-fate-commitment-of-myogenic-and-adipogenic-cells-in-skeletal-muscle
#15
Wenjuan Sun, Ting He, Chunfu Qin, Kai Qiu, Xin Zhang, Yanhong Luo, Defa Li, Jingdong Yin
Mechanism controlling myo-adipogenic balance in skeletal muscle is of great significance for human skeletal muscle dysfunction and myopathies as well as livestock meat quality. In the present study, two cell subpopulations with particular potency of adipogenic or myogenic differentiation were isolated from neonatal porcine longissimus dorsi using the preplate method to detect mechanisms underlying distinct fate commitment of myogenic and adipogenic cells in skeletal muscle. Both cells share a common surface expression profile of CD29(+)CD31(-)CD34(-)CD90(+)CD105(+), verifying their mesenchymal origin...
March 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28260165/l-arginine-promotes-protein-synthesis-and-cell-growth-in-brown-adipocyte-precursor-cells-via-the-mtor-signal-pathway
#16
Xi Ma, Meng Han, Defa Li, Shengdi Hu, Kyler R Gilbreath, Fuller W Bazer, Guoyao Wu
L-Arginine has been reported to enhance brown adipose tissue developments in fetal lambs of obese ewes, but the underlying mechanism is unknown. The present study tested the hypothesis that L-arginine stimulates growth and development of brown adipocyte precursor cells (BAPCs) through activation of mammalian target of rapamycin cell signaling. BAPCs isolated from fetal lambs at day 90 of gestation were incubated   for 6 h in arginine-free DMEM, and then cultured in DMEM with concentrations of 50, 100, 200, 500 or 1000 μmol L-arginine/L for 24-96 h...
March 4, 2017: Amino Acids
https://www.readbyqxmd.com/read/28241738/response-of-micrornas-to-cold-treatment-in-the-young-spikes-of-common-wheat
#17
Guoqi Song, Rongzhi Zhang, Shujuan Zhang, Yulian Li, Jie Gao, Xiaodong Han, Mingli Chen, Jiao Wang, Wei Li, Genying Li
BACKGROUND: MicroRNAs (miRNAs) are a class of small non-coding RNAs that play important roles in biotic and abiotic stresses by regulating their target genes. For common wheat, spring frost damage frequently occurs, especially when low temperature coincides with plants at early floral organ differentiation, which may result in significant yield loss. Up to date, the role of miRNAs in wheat response to frost stress is not well understood. RESULTS: We report here the sequencing of small RNA transcriptomes from the young spikes that were treated with cold stress and the comparative analysis with those of the control...
February 28, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28219317/dietary-fiber-gap-and-host-gut-microbiota
#18
REVIEW
Meng Han, Congmin Wang, Ping Liu, Defa Li, Yuan Li, Xi Ma
Accumulating evidence is dramatically increasing the access to the facts that the gut microbiota plays a pivotal role in host metabolism and health, which revealed the possibility of a plethora of associations between gut bacteria and human diseases. Several functional roles are carried out by a major class of the host's diet, such as fiber. Fiber is the main source of microbiota-accessible carbohydrate in the diet of humans. In the modern diet, it is difficult to intake sufficient dietary fiber as recommended...
May 10, 2017: Protein and Peptide Letters
https://www.readbyqxmd.com/read/28111434/effects-of-proteinate-complex-zinc-on-growth-performance-hepatic-and-splenic-trace-elements-concentrations-antioxidative-function-and-immune-functions-in-weaned-piglets
#19
Yue She, Qiang Huang, Defa Li, Xiangshu Piao
OBJECTIVE: To assess the effects of proteinate complex zinc (PC-Zn) on growth performance, antioxidative function, trace element concentrations and immune function in weaned piglets. METHODS: Three hundred newly weaned barrows (Duroc×Landrace×Yorkshire), 28 days of age, were randomly allotted to 3 dietary groups of 5 replicate pens per group for 4 weeks of feeding. Experimental diets were: i) zinc deficient diet (ZnD, 24 mg/kg Zn supplementation from ZnSO4), ii) inorganic Zn diet supplemented with 120 mg/kg of Zn from Zn sulfate (ZnSO4), and iii) organic Zn diet supplemented with 120 mg/kg of Zn from PC-Zn...
August 2017: Asian-Australasian Journal of Animal Sciences
https://www.readbyqxmd.com/read/28059666/mtorc1-mediated-nrbf2-phosphorylation-functions-as-a-switch-for-the-class-iii-ptdins3k-and-autophagy
#20
Xi Ma, Shen Zhang, Long He, Yueguang Rong, Livia Wilz Brier, Qiming Sun, Rong Liu, Weiliang Fan, She Chen, Zhenyu Yue, Joungmok Kim, Kun-Liang Guan, Defa Li, Qing Zhong
NRBF2/Atg38 has been identified as the fifth subunit of the macroautophagic/autophagic class III phosphatidylinositol 3-kinase (PtdIns3K) complex, along with ATG14/Barkor, BECN1/Vps30, PIK3R4/p150/Vps15 and PIK3C3/Vps34. However, its functional mechanism and regulation are not fully understood. Here, we report that NRBF2 is a fine tuning regulator of PtdIns3K controlled by phosphorylation. Human NRBF2 is phosphorylated by MTORC1 at S113 and S120. Upon nutrient starvation or MTORC1 inhibition, NRBF2 phosphorylation is diminished...
March 4, 2017: Autophagy
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