keyword
https://read.qxmd.com/read/38628297/pediatric-pulmonary-milestones-2-0-development-lessons-learned-and-future-directions
#1
JOURNAL ARTICLE
Laura E Chiel, Erica L Stevens, Lara C Bishay, Melanie S Collins, Jennifer A Rama, Laura Edgar, Sydney McLean, Ida Haynes, Hiren Muzumdar, Pnina Weiss, Debra Boyer, B Louise Giles
Pediatric pulmonology fellowship training programs are required by the Accreditation Council for Graduate Medical Education to report Pediatric Subspecialty Milestones biannually to track fellow progress. However, several issues, such as lack of subspecialty-specific context and ambiguous language, have raised concerns about their validity and applicability to use for fellow assessment and curriculum development. In this Perspective, we briefly share the process of the Pediatric Pulmonology Milestones 2.0 Work Group in creating new specialty-specific Milestones and tailoring information on the Harmonized Milestones to pediatric pulmonologists, with the goal of improving the Milestones' utility for stakeholders, including pulmonology fellows, faculty, program directors, and accrediting bodies...
March 2024: ATS scholar
https://read.qxmd.com/read/38511139/looking-beyond-year-1-in-the-molecular-era-of-pediatric-brain-tumor-diagnosis-confirmatory-testing-of-germline-variants-found-on-tumor-sequencing
#2
JOURNAL ARTICLE
Brittany L Greene, Shannon M Stasi, Michelle A Ting, Natalie Waligorski, Bonnie L Cole, Christina M Lockwood, Vera A Paulson, Jillian G Buchan, Amy Lee, Jeffrey G Ojemann, Richard G Ellenbogen, Jeffrey Stevens, Sarah E S Leary
PURPOSE: Somatic molecular profiling of pediatric brain tumors aids with the diagnosis and treatment of patients with a variety of high- and low-grade central nervous system neoplasms. Here, we report follow-up targeted germline evaluation for patients with possible germline variants following tumor only testing in the initial year in which somatic molecular testing was implemented at a single institution. PATIENTS AND METHODS: Somatic testing was completed for all tumors of the central nervous system (CNS) undergoing diagnostic workup at Seattle Children's Hospital during the study period of November 2015 to November 2016...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38437895/identifying-racial-and-ethnic-disparities-in-acute-inpatient-rehabilitation
#3
JOURNAL ARTICLE
Amanda A Herrmann, Bo B Podgorski, Sarah J Hatton, Ella A Chrenka, Leah R Hanson, Steven D Jackson
OBJECTIVE: To investigate whether racial, ethnic, and linguistic disparities exist upon discharge from an acute inpatient rehabilitation facility (IRF) by examining change in FIM score and discharge destination. DESIGN: This is a retrospective study using our IRF's data from the Uniform Data System of Medical Rehabilitation (UDSMR) from 2013 to 2019. Functional independence measure (FIM) and discharge destination were compared between race, language, and ethnic groups with adjustment for patient characteristics...
March 2, 2024: Archives of Physical Medicine and Rehabilitation
https://read.qxmd.com/read/38196692/kolb-meets-quality-applying-learning-theory-to-a-process-improvement-and-safety-curriculum
#4
JOURNAL ARTICLE
May M Lee, Santhi I Kumar
The healthcare landscape is changing, and the Accreditation Council for Graduate Medical Education has recognized the importance of training our physician workforce to demonstrate competency in quality, safety, and process improvement. In the renewal of our quality improvement and patient safety curriculum, we set out to create an impactful and relevant course of study using adult learning theories as a scaffold to design the curriculum and inform our teaching methods. In this Perspective, we describe a few key learning theories and demonstrate how we have used them in the teaching of quality improvement and patient safety concepts...
December 2023: ATS scholar
https://read.qxmd.com/read/38182402/multisite-clinical-cross-validation-and-variant-interpretation-of-a-next-generation-sequencing-panel-for-lymphoid-cancer-prognostication
#5
JOURNAL ARTICLE
Peter J B Sabatini, Josh Bridgers, Shujun Huang, Gregory Downs, Tong Zhang, Clare Sheen, Nicole Park, Robert Kridel, Marco A Marra, Christian Steidl, David W Scott, Aly Karsan
AIMS: Genomic sequencing of lymphomas is under-represented in routine clinical testing despite having prognostic and predictive value. Clinical implementation is challenging due to a lack of consensus on reportable targets and a paucity of reference samples. We organised a cross-validation study of a lymphoma-tailored next-generation sequencing panel between two College of American Pathologists (CAP)-accredited clinical laboratories to mitigate these challenges. METHODS: A consensus for the genomic targets was discussed between the two institutes based on recurrence in diffuse large B-cell lymphoma, follicular lymphoma, mantle cell lymphoma, chronic lymphocytic leukaemia and T-cell lymphomas...
January 5, 2024: Journal of Clinical Pathology
https://read.qxmd.com/read/38113412/systems-based-practice-in-graduate-medical-education-evolving-toward-an-ideal-future-state
#6
JOURNAL ARTICLE
Tahara D Bhate, Javeed Sukhera, Sasha Litwin, Teresa M Chan, Brian M Wong, Andrea Smeraglio
Systems-based practice (SBP) was first introduced as a core competency in graduate medical education (GME) in 2002 by the Accreditation Council for Graduate Medical Education as part of the Outcomes Project. While inclusion of SBP content in GME has become increasingly common, there have also been well-documented stumbling blocks, including perceptions that SBP has eroded the amount of curricular time available for more medically focused competencies, is not relevant for some practice contexts, and is not introduced early enough in training...
December 19, 2023: Academic Medicine
https://read.qxmd.com/read/38028588/reclassifying-variations-of-unknown-significance-in-diseases-affecting-saudi-arabia-s-population-reveal-new-associations
#7
JOURNAL ARTICLE
Mariam M Al Eissa, Raniah S Alotibi, Bader Alhaddad, Taghrid Aloraini, Manar S Samman, Abdulrahman AlAsiri, Mohamed Abouelhoda, Amerh S AlQahtani
Introduction: Physicians face diagnostic dilemmas upon reports indicating disease variants of unknown significance (VUS). The most puzzling cases are patients with rare diseases, where finding another matched genotype and phenotype to associate their results is challenging. This study aims to prove the value of updating patient files with new classifications, potentially leading to better assessment and prevention. Methodology: We recruited retrospective phenotypic and genotypic data from King Saud Medical City, Riyadh, Kingdom of Saudi Arabia...
2023: Frontiers in Genetics
https://read.qxmd.com/read/37980237/a-theoretical-and-practical-approach-to-quality-improvement-education
#8
JOURNAL ARTICLE
Joanne Mendoza, Elisa Hampton, Lori Singleton
Quality Improvement (QI) knowledge and skills are required at all levels of physician training. System improvement efforts need to include understanding of health disparities and design of interventions to reduce those disparities, thus health equity needs to be integrated into QI education. Payors, accreditation bodies and health systems' emphases on QI result in the need for QI curricula that meet the needs of diverse learners. This article presents a theoretical background and practical tools for designing, implementing, and evaluating a QI educational program across the spectrum of physician training with an emphasis on competency-based education and a goal of continuous practice improvement...
November 16, 2023: Current Problems in Pediatric and Adolescent Health Care
https://read.qxmd.com/read/37870799/social-determinants-of-health-in-family-medicine-residency-a-national-survey-of-program-directors
#9
JOURNAL ARTICLE
Katherine M Wright, Paul Ravenna, Santina Wheat, Carla M Villarreal, Deborah S Clements, Peter F Cronholm
BACKGROUND AND OBJECTIVES: Social factors account for most health outcomes, underscoring the need to address social determinants of health (SDH) to eliminate health disparities. Our objectives are (1) to describe the scope of formal SDH curricula in family medicine residency, (2) to identify residency program characteristics associated with integrated core curriculum components to teach SDH, and (3) to identify barriers to addressing SDH in residency. METHODS: We distributed a cross-sectional survey to all family medicine residency program directors (PDs) accredited by the Accreditation Council for Graduate Medical Education as identified by the Association of Family Medicine Residency Directors...
September 25, 2023: Family Medicine
https://read.qxmd.com/read/37748087/gathering-trainee-feedback-to-improve-programs-with-low-annual-acgme-survey-content-area-compliance-a-pilot-study
#10
JOURNAL ARTICLE
Mara M Hoffert, Leslie Pfeiffer, Molly Hepke, Wendy Brink, Jennifer Newman, Karla D Passalacqua, Kimberly Baker-Genaw
PROBLEM: Systematically investigating annual Accreditation Council for Graduate Medical Education (ACGME) Resident/Fellow Survey results by directly gathering trainee feedback could uncover training program problems and clarify misunderstandings as they arise, leading to faster corrective actions and program improvement. APPROACH: The Focus Group Forum (FGF) was created based on the utilization-focused evaluation approach to systematically gather comprehensive, high-quality, actionable trainee feedback on specific annual ACGME survey results and involve trainees in program improvement (Henry Ford Hospital, 2021)...
September 25, 2023: Academic Medicine
https://read.qxmd.com/read/37308886/healthyrhearts-reducing-cholesterol-in-rural-adults-via-telehealth-based-medical-nutrition-therapy-protocol-for-a-cluster-randomised-controlled-trial
#11
JOURNAL ARTICLE
Tracy L Schumacher, Jaimee Herbert, Jennifer May, Shanthi Ramanathan, Leanne J Brown, Michelle Guppy, Annabelle Williams, Megan E Rollo, John Attia, Clare E Collins
BACKGROUND: Few randomised controlled trials specifically focus on prevention in rural populations. Cardiovascular disease (CVD) contributes to approximately one quarter of deaths in Australia. Nutrition is a key component affecting many risk factors associated with CVD, including hypercholesterolaemia. However, access to medical nutrition therapy (MNT) is limited for people living in rural areas, potentially exacerbating inequities related to health outcomes. Telehealth services present an opportunity to improve MNT access and address healthcare disparities for rural populations...
June 12, 2023: BMC Cardiovascular Disorders
https://read.qxmd.com/read/37272760/a-pilot-study-of-on-site-evaluation-as-external-quality-assessment-for-iso-15189-accreditation-of-laboratories-performing-next-generation-sequencing-oncology-tests
#12
JOURNAL ARTICLE
Mendamar Ravzanaadii, Satomi Asai, Hidefumi Kakizoe, Munkh-Erdene Natsagdorj, Hayato Miyachi
BACKGROUND: As next-generation sequencing (NGS) oncology tests vary by platform, application, and target of genes, specific methods for external quality assessment (EQA) have not been universally applied. Hence, we have attempted to implement on-site evaluation as EQA in the accreditation program under ISO 15189 for laboratories that perform NGS oncology tests. METHODS: A total of 10 laboratories that performed NGS oncology tests were enrolled. Two types of EQA samples were prepared (Acrometrix Oncology Hotspot Control DNA and OncoSpan gDNA DNA samples), and the variant allele frequency of targeted genes was assigned...
June 5, 2023: Journal of Clinical Laboratory Analysis
https://read.qxmd.com/read/37251831/potentialities-and-priorities-for-higher-educational-development-in-saudi-arabia-for-the-next-decade-critical-reflections-of-the-vision-2030-framework
#13
JOURNAL ARTICLE
Khalid Mohiuddin, Osman A Nasr, Mohamed Nadhmi Miladi, Huda Fatima, Samreen Shahwar, Quadri Noorulhasan Naveed
Contributing to Vision 2030, Saudi higher educational institutions (HEIs) must reform their education system, reevaluate their potentialities, and priorities to support higher education development in achieving the Vision theme. With this goal, several educational innovation projects have been introduced to attain the vision's higher educational development strategic objectives. This study investigates the HEIs' current practices and analyses their achievements and the progress toward achieving the Vision's higher education development goals for the first review cycle (2016-2020) of the Vision...
May 2023: Heliyon
https://read.qxmd.com/read/37064491/what-to-know-about-2-0-revisions-to-the-pediatric-emergency-medicine-milestones
#14
JOURNAL ARTICLE
Selin T Sagalowsky, Sherri L Rudinsky, James M Gray, Laura Edgar
INTRODUCTION: The Accreditation Council for Graduate Medical Education (ACGME) adopted educational milestones for trainee assessment in 2013, as a key component of the Next Accreditation System. Two years later, the ACGME, American Board of Pediatrics (ABP), and American Board of Emergency Medicine (ABEM) collaborated to create specialty-specific subcompetencies in pediatric emergency medicine (PEM). Since that time, emerging data have demonstrated the need to revise specialty milestones...
April 2023: AEM Education and Training
https://read.qxmd.com/read/37039943/association-between-homologous-recombination-gene-variants-and-efficacy-of-oxaliplatin-based-chemotherapy-in-advanced-pancreatic-cancer-prospective-multicenter-observational-study
#15
JOURNAL ARTICLE
Tomohiro Kondo, Masashi Kanai, Junichi Matsubara, Daisuke Yamaguchi, Takashi Ura, Tadayuki Kou, Toshinao Itani, Motoo Nomura, Taro Funakoshi, Akira Yokoyama, Keitaro Doi, Masashi Tamaoki, Michio Yoshimura, Norimitsu Uza, Takahiro Yamada, Toshihiko Masui, Sachiko Minamiguchi, Shigemi Matsumoto, Hideki Ishikawa, Manabu Muto
Next-generation sequencing (NGS)-based gene profiling can identify patients with pancreatic cancer with homologous recombinant repair gene pathogenic variants (HRRv). Several retrospective studies have reported a positive association between HRRv and the efficacy of platinum-based chemotherapy. However, this association remains to be validated in a prospective study. This multicenter, prospective, observational study included patients with histologically confirmed unresectable or recurrent pancreatic cancer who required systemic chemotherapy...
April 11, 2023: Medical Oncology
https://read.qxmd.com/read/37037688/selection-of-patient-reported-outcomes-measures-for-implementation-in-the-metabolic-and-bariatric-surgery-accreditation-quality-improvement-program
#16
JOURNAL ARTICLE
Meridith E Greene, Roberta E Goldman, Matthew M Hutter
BACKGROUND: The Metabolic and Bariatric Surgery Accreditation Quality Improvement Program (MBSAQIP) assesses safety after metabolic and bariatric surgery and the impact on weight and obesity-related diseases. However, changes in quality of life are likely what matters most to patients, and these are not currently assessed. The best way to measure health-related quality of life (HRQoL) is to use validated patient-reported outcomes measures (PROMs), which capture patients' perspectives of their quality of life both before and after surgery...
August 2023: Surgery for Obesity and Related Diseases
https://read.qxmd.com/read/36980591/impact-of-molecular-testing-using-next-generation-sequencing-in-the-clinical-management-of-patients-with-non-small-cell-lung-cancer-in-a-public-healthcare-hospital
#17
JOURNAL ARTICLE
Javier Simarro, Gema Pérez-Simó, Nuria Mancheño, Emilio Ansotegui, Carlos Francisco Muñoz-Núñez, José Gómez-Codina, Óscar Juan, Sarai Palanca
Next-generation sequencing (NGS) is a molecular approach able to provide a comprehensive molecular profile of non-small cell lung cancer (NSCLC). The broad spectrum of biomarker-guided therapies has positioned molecular diagnostic laboratories as a central component of patient clinical management. Here, we show the results of an UNE-EN ISO 15189:2022 NGS-accredited assay in a cohort of 350 patients. TP53 (51.0%), KRAS (26.6%) and EGFR (12.9%) were the most frequently mutated genes. Furthermore, we detected co-occurring and mutually exclusive alterations, as well as distinct molecular profiles according to sex and smoking habits...
March 10, 2023: Cancers
https://read.qxmd.com/read/36972791/brain-somatic-mosaicism-in-epilepsy-bringing-results-back-to-the-clinic
#18
JOURNAL ARTICLE
Alissa M D'Gama, Annapurna Poduri
Over the past decade, there has been tremendous progress in understanding brain somatic mosaicism in epilepsy in the research setting. Access to resected brain tissue samples from patients with medically refractory epilepsy undergoing epilepsy surgery has been key to making these discoveries. In this review, we discuss the gap between making discoveries in the research setting and bringing results back to the clinical setting. Current clinical genetic testing mainly uses clinically accessible tissue samples, like blood and saliva, and can detect inherited and de novo germline variants and potentially non-brain-limited mosaic variants that have resulted from post-zygotic mutation (also called "somatic mutations")...
March 25, 2023: Neurobiology of Disease
https://read.qxmd.com/read/36870521/analytical-evaluation-and-sigma-metrics-of-6-next-generation-chemistry-assays-on-the-abbott-architect-system
#19
JOURNAL ARTICLE
Annie Ren, Xiao Yan Wang, Pow Lee Cheng, Davor Brinc, Marvin I Berman, Vathany Kulasingam
BACKGROUND: We evaluated analytical and Sigma performance for 6 next generation chemistry assays on the Abbott Architect c8000 system. METHODS: Albumin with bromocresol purple or green, amylase, cholesterol, total protein, and urea nitrogen were analyzed using photometric technology. Analytical performance goals were defined based on Accreditation Canada Diagnostics (ACD) and Clinical Laboratory Improvement Amendments (CLIA). Precision study consisted of testing 2 quality control concentrations and 3patient serum sample pools, twice a day in quintuplicate over 5 days...
March 2, 2023: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://read.qxmd.com/read/36858553/-patient-safety-management-practices-by-community-pharmacy-pharmacists%C3%AF-telephone-follow-up-by-community-pharmacy-pharmacists-in-cancer-drug-therapy%C3%AF
#20
JOURNAL ARTICLE
Hayato Murata
As a patient safety management practice in outpatient cancer drug therapy at community pharmacies, continuous follow-up after the dispensing of medication is required. In 2013, QOL Pharmacy Kohoku and its affiliated stores started the "Telephone Follow-up for Cancer Patients" program, which utilizes telephones and information communication devices to communicate with patients and provide information to hospitals. Specifically, follow-up, including phone calls, is used to ascertain medication status and side effects before the next visit to the hospital, and feedback is provided to the prescribing source using trace reports...
2023: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
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