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Maximilian Y Deng, Martin Sill, Jason Chiang, Jens Schittenhelm, Martin Ebinger, Martin U Schuhmann, Camelia-Maria Monoranu, Till Milde, Andrea Wittmann, Christian Hartmann, Clemens Sommer, Werner Paulus, Jutta Gärtner, Wolfgang Brück, Thomas Rüdiger, Alfred Leipold, Zane Jaunmuktane, Sebastian Brandner, Felice Giangaspero, Paolo Nozza, Jaume Mora, Andres Morales la Madrid, Ofelia Cruz Martinez, Jordan R Hansford, Torsten Pietsch, Anna Tietze, Pablo Hernáiz-Driever, Iris Stoler, David Capper, Andrey Korshunov, David W Ellison, Andreas von Deimling, Stefan M Pfister, Felix Sahm, David T W Jones
Diffuse leptomeningeal glioneuronal tumors (DLGNT) represent rare CNS neoplasms which have been included in the 2016 update of the WHO classification. The wide spectrum of histopathological and radiological features can make this enigmatic tumor entity difficult to diagnose. In recent years, large-scale genomic and epigenomic analyses have afforded insight into key genetic alterations occurring in multiple types of brain tumors and provide unbiased, complementary tools to improve diagnostic accuracy. Through genome-wide DNA methylation screening of > 25,000 tumors, we discovered a molecularly distinct class comprising 30 tumors, mostly diagnosed histologically as DLGNTs...
May 15, 2018: Acta Neuropathologica
Anne Nielsen, Mikkel Bo Hansen, Anna Tietze, Kim Mouridsen
BACKGROUND AND PURPOSE: Treatment options for patients with acute ischemic stroke depend on the volume of salvageable tissue. This volume assessment is currently based on fixed thresholds and single imagine modalities, limiting accuracy. We wish to develop and validate a predictive model capable of automatically identifying and combining acute imaging features to accurately predict final lesion volume. METHODS: Using acute magnetic resonance imaging, we developed and trained a deep convolutional neural network (CNNdeep ) to predict final imaging outcome...
May 2, 2018: Stroke; a Journal of Cerebral Circulation
A C Baumruck, D Tietze, L K Steinacker, A A Tietze
In the present study we have developed and optimized a robust strategy for the synthesis of highly hydrophobic peptides, especially membrane proteins, exemplarily using the influenza B M2 proton channel (BM2(1-51)). This strategy is based on the native chemical ligation of two fragments, where the thioester fragment is formed from an oxo-ester peptide, which is synthesized using Fmoc-SPPS, and features an in situ cleavable solubilizing tag (ADO, ADO2 or ADO-Lys5 ). The nearly quantitative production of the ligation product was followed by an optimized work up protocol, resulting in almost quantitative desulfurization and Acm-group cleavage...
February 28, 2018: Chemical Science
Daniel Rettenwander, Günther J Redhammer, Marie Guin, Artur Benisek, Hannes Krüger, Olivier Guillon, Martin Wilkening, Frank Tietz, Jürgen Fleig
NASICON-based solid electrolytes with exceptionally high Na-ion conductivities are considered to enable future all solid-state Na-ion battery technologies. Despite 40 years of research the interrelation between crystal structure and Na-ion conduction is still controversially discussed and far from being fully understood. In this study, microcontact impedance spectroscopy combined with single crystal X-ray diffraction, and differential scanning calorimetry is applied to tackle the question how bulk Na-ion conductivity σbulk of sub-mm-sized flux grown Na3 Sc2 (PO4 )3 (NSP) single crystals is influenced by supposed phase changes (α, β, and γ phase) discussed in literature...
March 13, 2018: Chemistry of Materials: a Publication of the American Chemical Society
Soundararasu Senthilkumar, Guillermo Valdomir, Dhandapani Ganapathy, Yun Zhang, Lutz F Tietze
An enantioselective total synthesis of blennolide D and the enantiomers of blennolide E and F is described using an enantioselective Wacker-type oxidation followed by the formation of the lactone moiety. For the introduction of the hydroxyl group in the γ-lactone, a TEMPO-mediated α-oxygenation was used which was followed by a benzylic oxidation and deprotection to give the desired compounds. In addition, an unknown diastereomer was synthesized.
March 28, 2018: Organic Letters
Max L Tietze, Johannes Benduhn, Paul Pahner, Bernhard Nell, Martin Schwarze, Hans Kleemann, Markus Krammer, Karin Zojer, Koen Vandewal, Karl Leo
Fermi level control by doping is established since decades in inorganic semiconductors and has been successfully introduced in organic semiconductors. Despite its commercial success in the multi-billion OLED display business, molecular doping is little understood, with its elementary steps controversially discussed and mostly-empirical-materials design. Particularly puzzling is the efficient carrier release, despite a presumably large Coulomb barrier. Here we quantitatively investigate doping as a two-step process, involving single-electron transfer from donor to acceptor molecules and subsequent dissociation of the ground-state integer-charge transfer complex (ICTC)...
March 21, 2018: Nature Communications
Taukeer A Khan, Torsten Fornefeld, Dennis Hübner, Philipp Vana, Lutz F Tietze
A palladium-catalyzed 4-fold domino reaction consisting of two carbopalladation reactions and two C-H activation reactions, followed by the introduction of an acrylate moiety, led to the tetra-substituted helical alkene A2, using the dialkyne A3 as a substrate. The alkene was copolymerized with butyl acrylate by using the reversible addition-fragmentation chain transfer polymerization (RAFT) to give the desired polymeric switch A1.
March 20, 2018: Organic Letters
Elina Makino, Helen Klodnitsky, John Leonard, James Lillie, Troy C Lund, John Marshall, Jennifer Nietupski, Paul J Orchard, Weston P Miller, Clifford Phaneuf, Drew Tietz, Mariet L Varban, Marissa Donovan, Alexey Belenki
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.
March 19, 2018: Scientific Reports
Elina Makino, Helen Klodnitsky, John Leonard, James Lillie, Troy C Lund, John Marshall, Jennifer Nietupski, Paul J Orchard, Weston P Miller, Clifford Phaneuf, Drew Tietz, Mariet L Varban, Marissa Donovan, Alexey Belenki
Certain recessively inherited diseases result from an enzyme deficiency within lysosomes. In mucopolysaccharidoses (MPS), a defect in glycosaminoglycan (GAG) degradation leads to GAG accumulation followed by progressive organ and multiple system dysfunctions. Current methods of GAG analysis used to diagnose and monitor the diseases lack sensitivity and throughput. Here we report a LC-MS method with accurate metabolite mass analysis for identifying and quantifying biomarkers for MPS type I without the need for extensive sample preparation...
February 27, 2018: Scientific Reports
Kenan A J Bozhüyük, Florian Fleischhacker, Annabell Linck, Frank Wesche, Andreas Tietze, Claus-Peter Niesert, Helge B Bode
Peptides derived from non-ribosomal peptide synthetases (NRPSs) represent an important class of pharmaceutically relevant drugs. Methods to generate novel non-ribosomal peptides or to modify peptide natural products in an easy and predictable way are therefore of great interest. However, although the overall modular structure of NRPSs suggests the possibility of adjusting domain specificity and selectivity, only a few examples have been reported and these usually show a severe drop in production titre. Here we report a new strategy for the modification of NRPSs that uses defined exchange units (XUs) and not modules as functional units...
March 2018: Nature Chemistry
Sabrina Tietze, Ferdinand Singer, Sandra Lasota, Sandra Ebert, Johannes Landskron, Katrin Schwuchow, Klaus Stefan Drese, Gerhard Lindner
The monitoring of liquid-filled tubes with respect to the formation of soft deposition layers such as biofilms on the inner walls calls for non-invasive and long-term stable sensors, which can be attached to existing pipe structures. For this task a method is developed, which uses an ultrasonic clamp-on device. This method is based on the impact of such deposition layers on the propagation of circumferential guided waves on the pipe wall. Such waves are partly converted into longitudinal compressional waves in the liquid, which are back-converted to guided waves in a circular cross section of the pipe...
February 9, 2018: Sensors
Eliezer M Schwarz, Stephanie Tietz, John E Froehlich
The funding statement in the last sentence of the Acknowledgements section in the original publication is incorrect. The corrected Acknowledgements section is printed below.
April 2018: Photosynthesis Research
Sharri Junadi Mortensen, Shima Naebi Bjerrum, Stine Frost Hedegaard, Anna Tietze, Hanne Gottrup, Gorm von Oettingen
BACKGROUND: To improve the quality of care for brain cancer patients, the Danish Ministry of Health has set standards for the diagnosis and treatment. When a patient is suspected of having a malignant tumour involving the brain, it is required that a magnetic resonance imaging of the cerebrum (MRI-C) be obtained within seven calendar days of referral from a primary care provider. This standard has the potential to consume MR imaging time that might otherwise be used for evaluation or treatment monitoring of other patients...
April 2018: Acta Neurochirurgica
Pascal Heimer, Alesia A Tietze, Charlotte A Bäuml, Anja Resemann, Franz Josef Mayer, Detlev Suckau, Oliver Ohlenschläger, Daniel Tietze, Diana Imhof
Peptides and proteins carrying high numbers of cysteines can adopt various 3D structures depending on their disulfide connectivities. The unambiguous verification of such conformational isomers with more than two disulfide bonds is extremely challenging, and experimental strategies for their unequivocal structural analysis are largely lacking. We synthesized all 15 possible isomers of the 22mer conopeptide μ-PIIIA and applied 2D NMR spectroscopy and MS/MS for the elucidation of its structure. This study provides intriguing insights in how the disulfide connectivity alters the global fold of a toxin...
March 6, 2018: Analytical Chemistry
Sandra Simon, Eva Trost, Jennifer Bender, Stephan Fuchs, Burkhard Malorny, Wolfgang Rabsch, Rita Prager, Erhard Tietze, Antje Flieger
In Germany salmonellosis still represents the 2nd most common bacterial foodborne disease. The majority of infections are caused by Salmonella (S.) Typhimurium and S. Enteritidis followed by a variety of other broad host-range serovars. Salmonella Derby is one of the five top-ranked serovars isolated from humans and it represents one of the most prevalent serovars in pigs, thus bearing the potential risk for transmission to humans upon consumption of pig meat and products thereof. From November 2013 to January 2014 S...
May 2018: Food Microbiology
Mark D Sternlicht, Ute Wirkner, Sebastian Bickelhaupt, Ramon Lopez Perez, Alexandra Tietz, Kenneth E Lipson, Todd W Seeley, Peter E Huber
BACKGROUND: Fibrosis is a delayed side effect of radiation therapy (RT). Connective tissue growth factor (CTGF) promotes the development of fibrosis in multiple settings, including pulmonary radiation injury. METHODS: To better understand the cellular interactions involved in RT-induced lung injury and the role of CTGF in these responses, microarray expression profiling was performed on lungs of irradiated and non-irradiated mice, including mice treated with the anti-CTGF antibody pamrevlumab (FG-3019)...
January 18, 2018: Respiratory Research
Markus V Heppt, Valerie Letulé, Ieva Laniauskaite, Markus Reinholz, Julia K Tietze, Hans Wolff, Thomas Ruzicka, Elke C Sattler
Frontal fibrosing alopecia (FFA) describes the scarring, band-like recession of the frontotemporal hairline. Treatment is difficult, and currently, no evidence-based therapy exists. The purpose of this study is to report clinical features and treatment responses in a large cohort of patients with FFA. The authors analyzed a series of 72 patients with a clinical or histologic diagnosis of FFA. A total of 70 patients were female (97.2%), and 2 were male (2.8%). In females, the first onset of FFA was postmenopausal in 81...
February 2018: Facial Plastic Surgery: FPS
Christine Knoop, Michael Tietze, Christina Dornack, Thomas Raab
The biogas technology is a promising approach for the recovery of energy and fertilizer from municipal organic waste (MOW). However, only scarce information on the development of initial nutrient and heavy metal loads during processing is available. Therefore, this study investigates properties of source-separated MOW during treatment in a semi-industrial scale two-stage biogas plant and subsequent digestate composting including impurities removal. Data from 15 batch experiments was investigated by material and substance flow analysis...
March 2018: Bioresource Technology
Martin Schwarze, Benjamin D Naab, Max L Tietze, Reinhard Scholz, Paul Pahner, Fabio Bussolotti, Satoshi Kera, Daniel Kasemann, Zhenan Bao, Karl Leo
Efficient n-doping of organic semiconductors requires electron donating molecules with small ionization energies, making such n-dopants usually sensitive to degradation under air exposure. A workaround consists in the usage of air stable precursor molecules containing the actual n-doping species. Here, we systematically analyze the doping mechanism of the small molecule precursor o-MeO-DMBI-Cl, which releases a highly reducing o-MeO-DMBI radical upon thermal evaporation. n-Doping of bis-HFl-NTCDI yields air stable and highly conductive films suitable for application as electron transport layer in organic solar cells...
December 13, 2017: ACS Applied Materials & Interfaces
Daniel Tietze, Jana Sartorius, Banabithi Koley Seth, Kevin Herr, Pascal Heimer, Diana Imhof, Doreen Mollenhauer, Gerd Buntkowsky
A series of small, catalytically active metallopeptides, which were derived from the nickel superoxide dismutase (NiSOD) active site were employed to study the mechanism of superoxide degradation especially focusing on the role of the axial imidazole ligand. In the literature, there are contradicting propositions about the catalytic importance of the N-terminal histidine. Therefore, we studied the stability and activity of a set of eight NiSOD model peptides, which represent the major model systems discussed in the literature to date, yet differing in their length and their Ni-coordination...
December 8, 2017: Scientific Reports
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