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https://www.readbyqxmd.com/read/28421969/dystrophic-mineralization-of-costal-cartilage-in-hartley-guinea-pigs
#1
Alexandria M Schauer, Adrienne Schucker, Cathy S Carlson
Hartley guinea pigs are widely used animal models of disease, particularly in studies of osteoarthritis. The purpose of this study was to investigate lesions in the costal cartilage from 16 male, 5- to 6-month-old Hartley guinea pigs. Routine histological sections from the costal cartilage and costochondral junction (longitudinal and cross sections) and sternum (for evaluation of bone marrow) were examined. All 16 (100%) animals had histological lesions involving the costal cartilage that included matrix degeneration and mineralization, reduced cellularity, and evidence of chondrocyte necrosis...
April 2017: Toxicologic Pathology
https://www.readbyqxmd.com/read/28382381/-stable-disease-or-complete-response-a%C3%A2-critical-evaluation-of-the-radiologic-response-to-immune-checkpoint-blockade-in-advanced-melanoma
#2
J K Tietze, M Heppt, D Angelova, T Ruzicka, F Berger, C Berking
BACKGROUND: Rating the response of melanoma to immune checkpoint blockade (ICB) by conventional CT proves to be difficult, since response patterns and kinetics differ from the classical responses seen with other therapies. Hence, immune-related response criteria were developed. However, they are mainly based on the alteration of the diameter of lesions over time but do not include metabolic activity. OBJECTIVE: The aim of this study was to search for additional criteria to improve the interpretation of the radiologic images of patients with metastatic melanoma after ICB...
April 5, 2017: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/28376190/effects-of-ctgf-blockade-on-attenuation-and-reversal-of-radiation-induced-pulmonary-fibrosis
#3
Sebastian Bickelhaupt, Christian Erbel, Carmen Timke, Ute Wirkner, Monika Dadrich, Paul Flechsig, Alexandra Tietz, Johanna Pföhler, Wolfgang Gross, Peter Peschke, Line Hoeltgen, Hugo A Katus, Hermann-Josef Gröne, Nils H Nicolay, Rainer Saffrich, Jürgen Debus, Mark D Sternlicht, Todd W Seeley, Kenneth E Lipson, Peter E Huber
Background: Radiotherapy is a mainstay for the treatment of lung cancer that can induce pneumonitis or pulmonary fibrosis. The matricellular protein connective tissue growth factor (CTGF) is a central mediator of tissue remodeling. Methods: A radiation-induced mouse model of pulmonary fibrosis was used to determine if transient administration of a human antibody to CTGF (FG-3019) started at different times before or after 20 Gy thoracic irradiation reduced acute and chronic radiation toxicity...
August 1, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28356055/a-genome-wide-association-study-reveals-a-locus-for-bilateral-iridal-hypopigmentation-in-holstein-friesian-cattle
#4
Anne K Hollmann, Martina Bleyer, Andrea Tipold, Jasmin N Neßler, Wilhelm E Wemheuer, Ekkehard Schütz, Bertram Brenig
BACKGROUND: Eye pigmentation abnormalities in cattle are often related to albinism, Chediak-Higashi or Tietz like syndrome. However, mutations only affecting pigmentation of coat color and eye have also been described. Herein 18 Holstein Friesian cattle affected by bicolored and hypopigmented irises have been investigated. RESULTS: Affected animals did not reveal any ophthalmological or neurological abnormalities besides the specific iris color differences. Coat color of affected cattle did not differ from controls...
March 29, 2017: BMC Genetics
https://www.readbyqxmd.com/read/28342040/ancient-parasites-from-endemic-deer-from-cueva-parque-diana-archeological-site-patagonia-argentina
#5
María Ornela Beltrame, Eleonor Tietze, Alberto Enrique Pérez, Agustín Bellusci, Norma Haydée Sardella
The narrow Andean-Patagonian temperate rainforest strip in the west of southern South America is inhabited by two endemic species of cervids, the southern pudu (Pudu puda) and the huemul (Hippocamelus bisulcus), both cataloged as near threatened and threatened species, respectively. One of the possible causes of their declined number is the susceptibility to livestock diseases. Significant zooarchaeological records of both deer have been found throughout the Holocene from Patagonia. The present contribution reports the first paleoparasitological results obtained from coprolites of endemic deer from the archeological site "Cueva Parque Diana," Neuquén Province, Argentina, and discusses the possible diseases found in ancient times...
March 24, 2017: Parasitology Research
https://www.readbyqxmd.com/read/28298040/noninvasive-assessment-of-isocitrate-dehydrogenase-mutation-status-in-cerebral-gliomas-by-magnetic-resonance-spectroscopy-in-a-clinical-setting
#6
Anna Tietze, Changho Choi, Bruce Mickey, Elizabeth A Maher, Benedicte Parm Ulhøi, Ryan Sangill, Yasmin Lassen-Ramshad, Slavka Lukacova, Leif Østergaard, Gorm von Oettingen
OBJECTIVE Mutations in the isocitrate dehydrogenase (IDH) genes are of proven diagnostic and prognostic significance for cerebral gliomas. The objective of this study was to evaluate the clinical feasibility of using a recently described method for determining IDH mutation status by using magnetic resonance spectroscopy (MRS) to detect the presence of 2-hydroxyglutarate (2HG), the metabolic product of the mutant IDH enzyme. METHODS By extending imaging time by 6 minutes, the authors were able to include a point-resolved spectroscopy (PRESS) MRS sequence in their routine glioma imaging protocol...
March 3, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28290206/diverse-applications-of-nanomedicine
#7
Beatriz Pelaz, Christoph Alexiou, Ramon A Alvarez-Puebla, Frauke Alves, Anne M Andrews, Sumaira Ashraf, Lajos P Balogh, Laura Ballerini, Alessandra Bestetti, Cornelia Brendel, Susanna Bosi, Monica Carril, Warren C W Chan, Chunying Chen, Xiaodong Chen, Xiaoyuan Chen, Zhen Cheng, Daxiang Cui, Jianzhong Du, Christian Dullin, Alberto Escudero, Neus Feliu, Mingyuan Gao, Michael George, Yury Gogotsi, Arnold Grünweller, Zhongwei Gu, Naomi J Halas, Norbert Hampp, Roland K Hartmann, Mark C Hersam, Patrick Hunziker, Ji Jian, Xingyu Jiang, Philipp Jungebluth, Pranav Kadhiresan, Kazunori Kataoka, Ali Khademhosseini, Jindřich Kopeček, Nicholas A Kotov, Harald F Krug, Dong Soo Lee, Claus-Michael Lehr, Kam W Leong, Xing-Jie Liang, Mei Ling Lim, Luis M Liz-Marzán, Xiaowei Ma, Paolo Macchiarini, Huan Meng, Helmuth Möhwald, Paul Mulvaney, Andre E Nel, Shuming Nie, Peter Nordlander, Teruo Okano, Jose Oliveira, Tai Hyun Park, Reginald M Penner, Maurizio Prato, Victor Puntes, Vincent M Rotello, Amila Samarakoon, Raymond E Schaak, Youqing Shen, Sebastian Sjöqvist, Andre G Skirtach, Mahmoud G Soliman, Molly M Stevens, Hsing-Wen Sung, Ben Zhong Tang, Rainer Tietze, Buddhisha N Udugama, J Scott VanEpps, Tanja Weil, Paul S Weiss, Itamar Willner, Yuzhou Wu, Lily Yang, Zhao Yue, Qian Zhang, Qiang Zhang, Xian-En Zhang, Yuliang Zhao, Xin Zhou, Wolfgang J Parak
The design and use of materials in the nanoscale size range for addressing medical and health-related issues continues to receive increasing interest. Research in nanomedicine spans a multitude of areas, including drug delivery, vaccine development, antibacterial, diagnosis and imaging tools, wearable devices, implants, high-throughput screening platforms, etc. using biological, nonbiological, biomimetic, or hybrid materials. Many of these developments are starting to be translated into viable clinical products...
March 28, 2017: ACS Nano
https://www.readbyqxmd.com/read/28244986/a-new-genome-mining-tool-redefines-the-lasso-peptide-biosynthetic-landscape
#8
Jonathan I Tietz, Christopher J Schwalen, Parth S Patel, Tucker Maxson, Patricia M Blair, Hua-Chia Tai, Uzma I Zakai, Douglas A Mitchell
Ribosomally synthesized and post-translationally modified peptide (RiPP) natural products are attractive for genome-driven discovery and re-engineering, but limitations in bioinformatic methods and exponentially increasing genomic data make large-scale mining of RiPP data difficult. We report RODEO (Rapid ORF Description and Evaluation Online), which combines hidden-Markov-model-based analysis, heuristic scoring, and machine learning to identify biosynthetic gene clusters and predict RiPP precursor peptides...
May 2017: Nature Chemical Biology
https://www.readbyqxmd.com/read/28242504/the-proportion-of-circulating-cd45ro-cd8-memory-t-cells-is-correlated-with-clinical-response-in-melanoma-patients-treated-with-ipilimumab
#9
Julia K Tietze, Daniela Angelova, Markus V Heppt, Markus Reinholz, William J Murphy, Michael Spannagl, Thomas Ruzicka, Carola Berking
BACKGROUND: Immune checkpoint blockade (ICB) has been a breakthrough in the treatment of metastatic melanoma. But with only about 20-40% long-term responders and severe side-effects in about 12-17%, finding predictive markers for treatment response is of great interest. METHODS: We prospectively assessed clinical data, haematologic parameters and freshly isolated peripheral blood mononuclear cells of 30 patients treated with ipilimumab (n = 21) and pembrolizumab (n = 9) prior to the first 4 cycles with ICB and before the first tumour assessment...
April 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28215874/first-paleoparasitological-record-of-digenean-eggs-from-a-native-deer-from-patagonia-argentina-cueva-parque-diana-archaeological-site
#10
Beltrame María Ornela, Tietze Eleonor, Pérez Alberto Enrique, Sardella Norma Haydeé
Eggs representative of a digenean species were found in coprolites belonged to an endemic deer from Patagonia. Samples were collected from the archaeological site named "Cueva Parque Diana". This site is a cave located at the Lanín National Park, Neuquén Province, Argentina. The coprolites were dated from 2370±70 to 580±60 years B.P. The eggs were ellipsoidal, operculated, yellowish and thin-shelled. Measurements (n=65) ranged from 120.0 to 142.5 (133.2±6.53) μm long and 62.5 to 87.5 (72.6±6.15) μm wide...
February 15, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28177212/amorphous-tin-oxide-as-a-low-temperature-processed-electron-transport-layer-for-organic-and-hybrid-perovskite-solar-cells
#11
Jérémy Barbé, Max L Tietze, Marios Neophytou, Banavoth Murali, Erkki Alarousu, Abdulrahman El Labban, Mutalifu Abulikemu, Wan Yue, Omar F Mohammed, Iain McCulloch, Aram Amassian, Silvano Del Gobbo
Chemical bath deposition (CBD) of tin oxide (SnO2) thin films as an electron-transport layer (ETL) in a planar-heterojunction n-i-p organohalide lead perovskite and organic bulk-heterojunction (BHJ) solar cells is reported. The amorphous SnO2 (a-SnO2) films are grown from a nontoxic aqueous bath of tin chloride at a very low temperature (55 °C) and do not require postannealing treatment to work very effectively as an ETL in a planar-heterojunction n-i-p organohalide lead perovskite or organic BHJ solar cells, in lieu of the commonly used ETL materials titanium oxide (TiO2) and zinc oxide (ZnO), respectively...
March 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28120501/enantioselective-total-synthesis-and-structure-confirmation-of-the-natural-dimeric-tetrahydroxanthenone-dicerandrol%C3%A2-c
#12
Dhandapani Ganapathy, Johannes R Reiner, Guillermo Valdomir, Soundararasu Senthilkumar, Lutz F Tietze
The first enantioselective total synthesis of natural dicerandrol C (1 c) as its enantiomer containing a dimeric tetrahydroxanthenone skeleton is described starting from the enantiopure chromane 6 which was obtained through a Wacker-type cyclization with >99 % ee. For the formation of the dimeric skeleton a palladium-catalyzed Suzuki reaction was used. The synthesis allowed the confirmation of the absolute configuration of the dicerandrols.
January 25, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28097925/improving-cancer-imaging-with-magnetic-nanoparticles-where-are-we-now
#13
Rainer Tietze, Christoph Alexiou
No abstract text is available yet for this article.
January 18, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28097592/-mycoses-of-the-skin
#14
Hans-Jürgen Tietz
No abstract text is available yet for this article.
January 2017: MMW Fortschritte der Medizin
https://www.readbyqxmd.com/read/28063356/nanoparticles-for-radiooncology-mission-vision-challenges
#15
REVIEW
Leoni A Kunz-Schughart, Anna Dubrovska, Claudia Peitzsch, Alexander Ewe, Achim Aigner, Samuel Schellenburg, Michael H Muders, Silke Hampel, Giuseppe Cirillo, Francesca Iemma, Rainer Tietze, Christoph Alexiou, Holger Stephan, Kristof Zarschler, Orazio Vittorio, Maria Kavallaris, Wolfgang J Parak, Lutz Mädler, Suman Pokhrel
Cancer is one of the leading non-communicable diseases with highest mortality rates worldwide. About half of all cancer patients receive radiation treatment in the course of their disease. However, treatment outcome and curative potential of radiotherapy is often impeded by genetically and/or environmentally driven mechanisms of tumor radioresistance and normal tissue radiotoxicity. While nanomedicine-based tools for imaging, dosimetry and treatment are potential keys to the improvement of therapeutic efficacy and reducing side effects, radiotherapy is an established technique to eradicate the tumor cells...
December 14, 2016: Biomaterials
https://www.readbyqxmd.com/read/28055267/microstructural-changes-in-the-thalamus-after-mild-traumatic-brain-injury-a-longitudinal-diffusion-and-mean-kurtosis-tensor-mri-study
#16
Erhard Trillingsgaard Næss-Schmidt, Jakob Udby Blicher, Simon Fristed Eskildsen, Anna Tietze, Brian Hansen, Peter William Stubbs, Sune Jespersen, Leif Østergaard, Jørgen Feldbæk Nielsen
PRIMARY OBJECTIVE: The primary aim of this study was to assess microstructural changes in the thalamus, hippocampus and corpus callosum with a fast mean kurtosis tensor (MKT) technique, in the acute and sub-acute phase after mTBI. It was hypothesized that MKT would differ between baseline and follow-up in patients. The secondary aim was to relate diffusion measures to symptoms of mTBI. RESEARCH DESIGN: A longitudinal case-control study. METHODS AND PROCEDURES: Twenty-seven patients with mTBI and 27 age- and gender-matched healthy controls were enrolled in the study...
2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/28024217/optimized-procedures-for-manganese-52-production-separation-and-radiolabeling
#17
Jesper Fonslet, Sabrina Tietze, Andreas I Jensen, Stephen A Graves, Gregory W Severin
Pressed chromium-powder cyclotron targets were irradiated with 16MeV protons, producing (52)Mn with average yields of 6.2±0.8MBq/µAh. Separation by solid-phase anion exchange from ethanol-HCl mixtures recovered 94.3±1.7% of (52)Mn and reduced the chromium content by a factor of 2.2±0.4×10(5). An additional AG 1-X8 column was used to remove copper, iron, cobalt and zinc impurities from the prepared (52)Mn in 8M HCl. The macrocyclic chelator DOTA was rapidly radiolabeled with (52)Mn in aq. ammonium acetate (pH 7...
March 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/27916464/subtype-specific-block-of-voltage-gated-k-channels-by-%C3%AE-conopeptides
#18
Enrico Leipold, Florian Ullrich, Markus Thiele, Alesia A Tietze, Heinrich Terlau, Diana Imhof, Stefan H Heinemann
The neurotoxic cone snail peptide μ-GIIIA specifically blocks skeletal muscle voltage-gated sodium (NaV1.4) channels. The related conopeptides μ-PIIIA and μ-SIIIA, however, exhibit a wider activity spectrum by also inhibiting the neuronal NaV channels NaV1.2 and NaV1.7. Here we demonstrate that those μ-conopeptides with a broader target range also antagonize select subtypes of voltage-gated potassium channels of the KV1 family: μ-PIIIA and μ-SIIIA inhibited KV1.1 and KV1.6 channels in the nanomolar range, while being inactive on subtypes KV1...
January 22, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27902858/reliable-estimation-of-microvascular-flow-patterns-in-patients-with-disrupted-blood-brain-barrier-using-dynamic-susceptibility-contrast-mri
#19
Mikkel Bo Hansen, Anna Tietze, Jayashree Kalpathy-Cramer, Elizabeth R Gerstner, Tracy T Batchelor, Leif Østergaard, Kim Mouridsen
PURPOSE: To present and quantify the performance of a method to compute tissue hemodynamic parameters from dynamic susceptibility contrast (DSC) MRI data in brain tissue with possible nonintact blood-brain barrier. THEORY AND MATERIALS AND METHODS: We propose a Bayesian scheme to obtain perfusion metrics, including capillary transit-time heterogeneity (CTH), from DSC-MRI data in the presence of contrast agent extravasation. Initial performance assessment is performed through simulations...
November 30, 2016: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/27892653/low-baseline-levels-of-nk-cells-may-predict-a-positive-response-to-ipilimumab-in-melanoma-therapy
#20
Julia K Tietze, Daniela Angelova, Markus V Heppt, Thomas Ruzicka, Carola Berking
The introduction of immune checkpoint blockade (ICB) has been a breakthrough in the therapy of metastatic melanoma. The influence of ICB on T-cell populations has been studied extensively, but little is known about the effect on NK cells. In this study, we analysed the relative and absolute amounts of NK cells and of the subpopulations of CD56(dim) and CD56(bright) NK cells among the peripheral blood mononuclear cells (PBMCs) of 32 patients with metastatic melanoma before and under treatment with ipilimumab or pembrolizumab by flow cytometry...
November 28, 2016: Experimental Dermatology
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