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https://www.readbyqxmd.com/read/29278862/frontal-fibrosing-alopecia-a-retrospective-analysis-of-72-patients-from-a-german-academic-center
#1
Markus V Heppt, Valerie Letulé, Ieva Laniauskaite, Markus Reinholz, Julia K Tietze, Hans Wolff, Thomas Ruzicka, Elke C Sattler
Frontal fibrosing alopecia (FFA) describes the scarring, band-like recession of the frontotemporal hairline. Treatment is difficult, and currently, no evidence-based therapy exists. The purpose of this study is to report clinical features and treatment responses in a large cohort of patients with FFA. The authors analyzed a series of 72 patients with a clinical or histologic diagnosis of FFA. A total of 70 patients were female (97.2%), and 2 were male (2.8%). In females, the first onset of FFA was postmenopausal in 81...
December 26, 2017: Facial Plastic Surgery: FPS
https://www.readbyqxmd.com/read/29278845/fate-of-nutrients-and-heavy-metals-during-two-stage-digestion-and-aerobic-post-treatment-of-municipal-organic-waste
#2
Christine Knoop, Michael Tietze, Christina Dornack, Thomas Raab
The biogas technology is a promising approach for the recovery of energy and fertilizer from municipal organic waste (MOW). However, only scarce information on the development of initial nutrient and heavy metal loads during processing is available. Therefore, this study investigates properties of source-separated MOW during treatment in a semi-industrial scale two-stage biogas plant and subsequent digestate composting including impurities removal. Data from 15 batch experiments was investigated by material and substance flow analysis...
December 10, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/29236472/analyzing-the-n-doping-mechanism-of-an-air-stable-small-molecule-precursor
#3
Martin Schwarze, Benjamin D Naab, Max L Tietze, Reinhard Scholz, Paul Pahner, Fabio Bussolotti, Satoshi Kera, Daniel Kasemann, Zhenan Bao, Karl Leo
Efficient n-doping of organic semiconductors requires electron donating molecules with small ionization energies, making such n-dopants usually sensitive to degradation under air exposure. A workaround consists in the usage of air stable precursor molecules containing the actual n-doping species. Here, we systematically analyze the doping mechanism of the small molecule precursor o-MeO-DMBI-Cl, which releases a highly reducing o-MeO-DMBI radical upon thermal evaporation. n-Doping of bis-HFl-NTCDI yields air stable and highly conductive films suitable for application as electron transport layer in organic solar cells...
December 13, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29222438/new-insights-into-the-mechanism-of-nickel-superoxide-degradation-from-studies-of-model-peptides
#4
Daniel Tietze, Jana Sartorius, Banabithi Koley Seth, Kevin Herr, Pascal Heimer, Diana Imhof, Doreen Mollenhauer, Gerd Buntkowsky
A series of small, catalytically active metallopeptides, which were derived from the nickel superoxide dismutase (NiSOD) active site were employed to study the mechanism of superoxide degradation especially focusing on the role of the axial imidazole ligand. In the literature, there are contradicting propositions about the catalytic importance of the N-terminal histidine. Therefore, we studied the stability and activity of a set of eight NiSOD model peptides, which represent the major model systems discussed in the literature to date, yet differing in their length and their Ni-coordination...
December 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29194882/burchard-franck-1926-2017
#5
Lutz F Tietze
Burchard Frank, Emeritus Professor of Organic Chemistry at the University of Münster, passed away on February 21, 2017. He was an internationally recognized natural-product chemist, who made important contributions to the field of biomimetic transformations of alkaloids, as well as the areas of pigments and toxins, and porphyrinoids.
November 30, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/29192353/effects-of-a-mobility-monitoring-system-on-the-cost-of-care-in-relation-to-reimbursement-at-swiss-nursing-homes-learnings-from-a-randomized-controlled-trial
#6
Mario Stark, Rigo Tietz, Heidrun Gattinger, Virpi Hantikainen, Stefan Ott
BACKGROUND/OBJECTIVE: Nursing homes in Switzerland are under pressure to efficiently coordinate staff activities to cover their personnel costs under the care financing system. In this study, the use of a mobility monitoring system accompanied with case conferences was investigated in order to improve sleep quality and estimate the cost benefit of this intervention. METHOD: In an open two-phase randomized controlled trial at three nursing homes, residents with cognitive impairment were randomly assigned to an intervention group and a control group...
December 1, 2017: Health Economics Review
https://www.readbyqxmd.com/read/29170034/bioequivalence-of-locally-acting-lozenges-evaluation-of-critical-in-vivo-parameters-and-first-steps-towards-a-bio-predictive-in-vitro-test-method
#7
Katharina Tietz, Sina I Gutknecht, Sandra Klein
Locally-acting lozenges are among the most common types of solid dosage forms applied in the oral cavity. Since no guidance on the in vitro demonstration of local bioequivalence is available, we wanted to develop a new bio-predictive test method for dissolution of lozenges based on a set of physiological parameters relevant to lozenge dissolution in the oral cavity. An in vivo sucking study determining the impact of different lozenge (candy) bases and flavours on sucking times, saliva osmolality and salivary flow rates was performed in 6 volunteers...
November 20, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29154390/circadian-profiling-reveals-higher-histamine-plasma-levels-and-lower-diamine-oxidase-serum-activities-in-24-of-patients-with-suspected-histamine-intolerance-compared-to-food-allergy-and-controls
#8
Theresa C Pinzer, Esther Tietz, Elisabeth Waldmann, Monic Schink, Markus F Neurath, Yurdagül Zopf
BACKGROUND: Histamine intolerance is thought to trigger manifold clinical symptoms after ingesting histamine-rich food due to reduced activity of diamine oxidase (DAO). No study has hitherto systematically assessed daily fluctuations of histamine levels and DAO activities in symptomatic patients. The aim of the study was to investigate the presence of histamine intolerance, to therefore establish day profiles of histamine levels and DAO activities, and to compare the results between patients with suspected histamine intolerance, food allergy and healthy controls...
November 20, 2017: Allergy
https://www.readbyqxmd.com/read/29153814/surgical-management-of-medically-refractory-tietze-syndrome
#9
Rebecca Gologorsky, Benjamin Hornik, Jeffrey Velotta
Tietze syndrome is a rare and benign cause of chest pain that may be confused with life-threatening conditions. Characteristic findings are painful, localized inflammation of the costosternal, sternoclavicular, or costochondral joints typically of the second and third ribs. We present a patient with severe, medically refractory symptoms consistent with Tietze syndrome. Although surgical management is not the typical treatment course, symptomatic control was eventually achieved with complete resection of the involved cartilage and adjacent rib...
December 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29151054/effect-of-ephedrine-and-phenylephrine-on-brain-oxygenation-and-microcirculation-in-anaesthetised-patients-with-cerebral-tumours-study-protocol-for-a-randomised-controlled-trial
#10
Klaus Ulrik Koch, Anna Tietze, Joel Aanerud, Gorm von Öettingen, Niels Juul, Jens Christian Hedemann Sørensen, Lone Nikolajsen, Leif Østergaard, Mads Rasmussen
INTRODUCTION: During brain tumour surgery, vasopressor drugs are commonly administered to increase mean arterial blood pressure with the aim of maintaining sufficient cerebral perfusion pressure. Studies of the commonly used vasopressors show that brain oxygen saturation is reduced after phenylephrine administration, but unaltered by ephedrine administration. These findings may be explained by different effects of phenylephrine and ephedrine on the cerebral microcirculation, in particular the capillary transit-time heterogeneity, which determines oxygen extraction efficacy...
November 17, 2017: BMJ Open
https://www.readbyqxmd.com/read/29095055/diffusion-mri-findings-in-patients-with-extensive-and-minimal-post-concussion-symptoms-after-mtbi-and-healthy-controls-a-cross-sectional-study
#11
Erhard Trillingsgaard Næss-Schmidt, Jakob Udby Blicher, Anna Tietze, Charlotte Ulrikka Rask, Susanne Wulff Svendsen, Andreas Schröder, Mille Møller Thastum, Astrid Høeg Tuborgh, Oana-Veronica Frederiksen, Leif Østergaard, Simon Fristed Eskildsen, Brian Hansen, Sune Jespersen, Jørgen Feldbæk Nielsen
PRIMARY OBJECTIVES: We hypothesized that the microstructure of the corpus callosum, thalamus and hippocampus, as measured with diffusion and Mean of the Kurtosis Tensor (MKT) MRI, differs between healthy subjects and patients with extensive and minimal post-concussion symptoms (PCS) and that MKT measures correlate with PCS severity and self-reported cognitive symptoms. RESEARCH DESIGN: A cross-sectional study comparing patients with extensive PCS and patients with minimal PCS 2-5 months after mild traumatic brain injury (mTBI) with each other and with an external healthy control group...
November 2, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29074951/pearls-in-running-drops-on-an-inclined-glass-substrate-excited-by-lamb-waves
#12
Wei Liang, Sabrina Tietze
We demonstrate that pearling droplets will be released from droplets as they sliding down a partially wetting glass plate excited by Lamb waves. During the movement, we find that the transitions at generating pearling are independent of the drop size and depend only on a critical capillary number Ca. Further up, the position of the pearls must be at or around the droplet's advancing or receding end of the initial state.
October 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29051575/substrate-recognition-by-two-different-p450s-evidence-for-conserved-roles-in-a-common-fold
#13
Drew R Tietz, Allison M Colthart, Susan Sondej Pochapsky, Thomas C Pochapsky
Cytochrome P450 monooxygenases CYP101A1 and MycG catalyze regio- and stereospecific oxidations of their respective substrates, d-camphor and mycinamicin IV. Despite the low sequence homology between the two enzymes (29% identity) and differences in size and hydrophobicity of their substrates, the conformational changes that occur upon substrate binding in both enzymes as determined by solution NMR methods show some striking similarities. Many of the same secondary structural features in both enzymes are perturbed, suggesting the existence of a common mechanism for substrate binding and recognition in the P450 superfamily...
October 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29035747/studies-on-the-adsorption-and-desorption-of-mitoxantrone-to-lauric-acid-albumin-coated-iron-oxide-nanoparticles
#14
Jan Zaloga, Artem Feoktystov, Vasil M Garamus, Weronika Karawacka, Alexander Ioffe, Thomas Brückel, Rainer Tietze, Christoph Alexiou, Stefan Lyer
A rational use of superparamagnetic iron oxide nanoparticles (SPIONs) in drug delivery, diagnostics, and other biomedical applications requires deep understanding of the molecular drug adsorption/desorption mechanisms for proper design of new pharmaceutical formulations. The adsorption and desorption of the cytostatic Mitoxantrone (MTO) to lauric acid-albumin hybrid coated particles SPIONs (SEON(LA-HSA)) was studied by Fourier transform infrared spectroscopy (FTIR), dynamic light scattering (DLS), surface titration, release experiments and small-angle neutron and X-ray scattering...
September 28, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29025153/atypical-tietze-s-syndrome-misdiagnosed-as-atypical-chest-pain-letter-to-the-editor
#15
Wangseok Do, Jiseok Baik, Eun-Soo Kim, Eun-A Lee, Bora Yoo, Hae-Kyu Kim
No abstract text is available yet for this article.
September 5, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29023277/diagnosis-and-treatment-of-slipping-rib-syndrome
#16
Cassidy M Foley, Dai Sugimoto, David P Mooney, William P Meehan, Andrea Stracciolini
OBJECTIVE: (1) To investigate the clinical presentation, diagnosis, and treatment of slipping rib syndrome in athletes; (2) to investigate the hooking maneuver for diagnosis of slipping rib syndrome. DESIGN: Retrospective chart review of 362 athletes with rib pain. SETTING: Pediatric-based sports medicine clinic between January 1, 1999, and March 1, 2014. PATIENTS: Costochondritis, Tietze, fractures, rib tip syndrome, and unclear diagnoses were excluded...
October 6, 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/28975583/photosystem-i-lhcii-megacomplexes-respond-to-high-light-and-aging-in-plants
#17
Eliezer M Schwarz, Stephanie Tietz, John E Froehlich
Photosystem II is known to be a highly dynamic multi-protein complex that participates in a variety of regulatory and repair processes. In contrast, photosystem I (PSI) has, until quite recently, been thought of as relatively static. We report the discovery of plant PSI-LHCII megacomplexes containing multiple LHCII trimers per PSI reaction center. These PSI-LHCII megacomplexes respond rapidly to changes in light intensity, as visualized by native gel electrophoresis. PSI-LHCII megacomplex formation was found to require thylakoid stacking, and to depend upon growth light intensity and leaf age...
October 3, 2017: Photosynthesis Research
https://www.readbyqxmd.com/read/28956078/-attitude-towards-organ-and-tissue-donation-in-europe-prerequisite-for-osteochondral-allograft-treatment
#18
REVIEW
S Schmidt, A Schulte, S Schwarz, N Hofmann, S Tietz, M Boergel, S U Sixt
BACKGROUND: The biggest obstacle to overcome for routine treatment of various pathologies with fresh osteochondral allograft is the availability of tissue for transplantation. Large fresh osteochondral allografts are usually harvested from organ donors, but in contrast to organs, tissues can be procured after cardiac arrest. OBJECTIVE: Medical staff as well the general public are much less aware of the possibilities and requirements of tissue donation compared to organ donation...
November 2017: Der Unfallchirurg
https://www.readbyqxmd.com/read/28953064/texas-team-academic-progression-and-iom-toolkit
#19
Helen Reid, Kathryn Tart, Mari Tietze, Nitha Mathew Joseph, Carson Easley
BACKGROUND: The Institute of Medicine (IOM) Future of Nursing report, identified eight recommendations for nursing to improve health care for all Americans. AIM: The Texas Team for Advancing Health Through Nursing embraced the challenge of implementing the recommendations through two diverse projects. METHOD: One group conducted a broad, online survey of leadership, practice, and academia, focusing on the IOM recommendations. The other focused specifically on academic progression through the use of CABNET (Consortium for Advancing Baccalaureate Nursing Education in Texas) articulation agreements...
August 4, 2017: Nursing Education Perspectives
https://www.readbyqxmd.com/read/28937963/ki67-and-lymphocytes-in-the-pretherapeutic-core-biopsy-of-primary-invasive-breast-cancer-positive-markers-of-therapy-response-prediction-and-superior-survival
#20
REVIEW
Claus M Schlotter, Lothar Tietze, Ulf Vogt, Carlos Villena Heinsen, Antje Hahn
Background Core needle biopsy plays a crucial role as diagnostic tool for BC. Both Ki67 and likely tumor-infiltrating lymphocytes (TILs) in the near future are determining the kind of systemic therapy. The role of TILs in BC is still an issue for clinical research, albeit preliminary results of neoadjuvant and adjuvant clinical studies already now highlight the crucial impact of TILs on therapy response and survival. Methods Evaluation of related publications (pubmed) and meeting abstracts (ASCO, SABCS). Results The monoclonal antibody Ki67 recognizing a nuclear antigene in proliferating cells is a positive marker of therapy response and superior survival...
September 22, 2017: Hormone Molecular Biology and Clinical Investigation
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