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https://www.readbyqxmd.com/read/28097925/improving-cancer-imaging-with-magnetic-nanoparticles-where-are-we-now
#1
Rainer Tietze, Christoph Alexiou
No abstract text is available yet for this article.
January 18, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28097592/-mycoses-of-the-skin
#2
Hans-Jürgen Tietz
No abstract text is available yet for this article.
January 2017: MMW Fortschritte der Medizin
https://www.readbyqxmd.com/read/28063356/nanoparticles-for-radiooncology-mission-vision-challenges
#3
REVIEW
Leoni A Kunz-Schughart, Anna Dubrovska, Claudia Peitzsch, Alexander Ewe, Achim Aigner, Samuel Schellenburg, Michael H Muders, Silke Hampel, Giuseppe Cirillo, Francesca Iemma, Rainer Tietze, Christoph Alexiou, Holger Stephan, Kristof Zarschler, Orazio Vittorio, Maria Kavallaris, Wolfgang J Parak, Lutz Mädler, Suman Pokhrel
Cancer is one of the leading non-communicable diseases with highest mortality rates worldwide. About half of all cancer patients receive radiation treatment in the course of their disease. However, treatment outcome and curative potential of radiotherapy is often impeded by genetically and/or environmentally driven mechanisms of tumor radioresistance and normal tissue radiotoxicity. While nanomedicine-based tools for imaging, dosimetry and treatment are potential keys to the improvement of therapeutic efficacy and reducing side effects, radiotherapy is an established technique to eradicate the tumor cells...
December 14, 2016: Biomaterials
https://www.readbyqxmd.com/read/28055267/microstructural-changes-in-the-thalamus-after-mild-traumatic-brain-injury-a-longitudinal-diffusion-and-mean-kurtosis-tensor-mri-study
#4
Erhard Trillingsgaard Næss-Schmidt, Jakob Udby Blicher, Simon Fristed Eskildsen, Anna Tietze, Brian Hansen, Peter William Stubbs, Sune Jespersen, Leif Østergaard, Jørgen Feldbæk Nielsen
PRIMARY OBJECTIVE: The primary aim of this study was to assess microstructural changes in the thalamus, hippocampus and corpus callosum with a fast mean kurtosis tensor (MKT) technique, in the acute and sub-acute phase after mTBI. It was hypothesized that MKT would differ between baseline and follow-up in patients. The secondary aim was to relate diffusion measures to symptoms of mTBI. RESEARCH DESIGN: A longitudinal case-control study. METHODS AND PROCEDURES: Twenty-seven patients with mTBI and 27 age- and gender-matched healthy controls were enrolled in the study...
January 5, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/28024217/optimized-procedures-for-manganese-52-production-separation-and-radiolabeling
#5
Jesper Fonslet, Sabrina Tietze, Andreas I Jensen, Stephen A Graves, Gregory W Severin
Pressed chromium-powder cyclotron targets were irradiated with 16MeV protons, producing (52)Mn with average yields of 6.2±0.8MBq/µAh. Separation by solid-phase anion exchange from ethanol-HCl mixtures recovered 94.3±1.7% of (52)Mn and reduced the chromium content by a factor of 2.2±0.4×10(5). An additional AG 1-X8 column was used to remove copper, iron, cobalt and zinc impurities from the prepared (52)Mn in 8M HCl. The macrocyclic chelator DOTA was rapidly radiolabeled with (52)Mn in aq. ammonium acetate (pH 7...
December 21, 2016: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/27916464/subtype-specific-block-of-voltage-gated-k-channels-by-%C3%AE-conopeptides
#6
Enrico Leipold, Florian Ullrich, Markus Thiele, Alesia A Tietze, Heinrich Terlau, Diana Imhof, Stefan H Heinemann
The neurotoxic cone snail peptide μ-GIIIA specifically blocks skeletal muscle voltage-gated sodium (NaV1.4) channels. The related conopeptides μ-PIIIA and μ-SIIIA, however, exhibit a wider activity spectrum by also inhibiting the neuronal NaV channels NaV1.2 and NaV1.7. Here we demonstrate that those μ-conopeptides with a broader target range also antagonize select subtypes of voltage-gated potassium channels of the KV1 family: μ-PIIIA and μ-SIIIA inhibited KV1.1 and KV1.6 channels in the nanomolar range, while being inactive on subtypes KV1...
January 22, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27902858/reliable-estimation-of-microvascular-flow-patterns-in-patients-with-disrupted-blood-brain-barrier-using-dynamic-susceptibility-contrast-mri
#7
Mikkel Bo Hansen, Anna Tietze, Jayashree Kalpathy-Cramer, Elizabeth R Gerstner, Tracy T Batchelor, Leif Østergaard, Kim Mouridsen
PURPOSE: To present and quantify the performance of a method to compute tissue hemodynamic parameters from dynamic susceptibility contrast (DSC) MRI data in brain tissue with possible nonintact blood-brain barrier. THEORY AND MATERIALS AND METHODS: We propose a Bayesian scheme to obtain perfusion metrics, including capillary transit-time heterogeneity (CTH), from DSC-MRI data in the presence of contrast agent extravasation. Initial performance assessment is performed through simulations...
November 30, 2016: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/27892653/low-baseline-levels-of-nk-cells-may-predict-a-positive-response-to-ipilimumab-in-melanoma-therapy
#8
Julia K Tietze, Daniela Angelova, Markus V Heppt, Thomas Ruzicka, Carola Berking
The introduction of immune checkpoint blockade (ICB) has been a breakthrough in the therapy of metastatic melanoma. The influence of ICB on T cell populations has been studied extensively but little is known about the effect on NK cells. In this study, we analysed the relative and absolute amounts of NK cells and of the subpopulations of CD56(dim) and CD56(bright) NK cells among the peripheral blood mononuclear cells (PBMCs) of 32 patients with metastatic melanoma before and under treatment with ipilimumab or pembrolizumab by flow cytometry...
November 28, 2016: Experimental Dermatology
https://www.readbyqxmd.com/read/27828971/development-of-a-bioinformatics-framework-for-the-detection-of-gene-conversion-and-the-analysis-of-combinatorial-diversity-in-immunoglobulin-heavy-chains-in-four-cattle-breeds
#9
Stefanie Walther, Manfred Tietze, Claus-Peter Czerny, Sven König, Ulrike S Diesterbeck
We have developed a new bioinformatics framework for the analysis of rearranged bovine heavy chain immunoglobulin (Ig) variable regions by combining and refining widely used alignment algorithms. This bioinformatics framework allowed us to investigate alignments of heavy chain framework regions (FRHs) and the separate alignments of FRHs and heavy chain complementarity determining regions (CDRHs) to determine their germline origin in the four cattle breeds Aubrac, German Black Pied, German Simmental, and Holstein Friesian...
2016: PloS One
https://www.readbyqxmd.com/read/27797509/targeting-reactive-carbonyls-for-identifying-natural-products-and-their-biosynthetic-origins
#10
Tucker Maxson, Jonathan I Tietz, Graham A Hudson, Xiao Rui Guo, Hua-Chia Tai, Douglas A Mitchell
Natural products (NPs) serve important roles as drug candidates and as tools for chemical biology. However, traditional NP discovery, largely based on bioassay-guided approaches, is biased toward abundant compounds and rediscovery rates are high. Orthogonal methods to facilitate discovery of new NPs are thus needed, and herein we describe an isotope tag-based expansion of reactivity-based NP screening to address these shortcomings. Reactivity-based screening is a directed discovery approach in which a specific reactive handle on the NP is targeted by a chemoselective probe to enable its detection by mass spectrometry...
November 23, 2016: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/27710977/the-systemic-management-of-advanced-melanoma-in-2016
#11
Markus V Heppt, Cecilia Dietrich, Saskia A Graf, Thomas Ruzicka, Julia K Tietze, Carola Berking
Melanoma is a common type of skin cancer with a high propensity to metastasize. Tyrosine kinase inhibitors targeting the mitogen-activated protein kinase (MAPK) pathway and immune checkpoint blockade have recently revolutionized the management of unresectable and metastatic disease. However, acquired resistance and primary non-response to therapy require novel treatment strategies and combinations. The purpose of this review is to provide a brief and up-to-date overview on the clinical management and current trial landscape in melanoma...
2016: Oncology Research and Treatment
https://www.readbyqxmd.com/read/27705891/comparison-of-percutaneous-closure-versus-surgical-femoral-cutdown-for-decannulation-of-large-sized-arterial-and-venous-access-sites-in-adults-after-successful-weaning-of-veno-arterial-extracorporeal-membrane-oxygenation
#12
Nicolas Majunke, Norman Mangner, Axel Linke, Enno Boudriot, Sandra Erbs, Franziska Tietz, Sabrina Wolff, Stephan Schürer, Gerhard Schuler, Marcus Sandri
OBJECTIVE: Surgical femoral cutdown for decannulation after veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is considered standard practice. However, access-site complications with this technique are not rare. The objective of this study is to evaluate feasibility, safety, and efficacy of a complete percutaneous decannulation procedure after VA-ECMO compared with the conventional surgical cutdown approach. METHODS: In 35 patients who were successfully weaned from VA-ECMO support, femoral artery and vein access sites were closed using a completely percutaneous approach in 15 patients, whereas 20 patients had conventional surgical cutdown for access-site closure...
October 2016: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/27700071/biosynthetic-timing-and-substrate-specificity-for-the-thiopeptide-thiomuracin
#13
Zhengan Zhang, Graham A Hudson, Nilkamal Mahanta, Jonathan I Tietz, Wilfred A van der Donk, Douglas A Mitchell
The biosynthesis of the thiopeptide thiomuracin is a well-orchestrated process involving a multitude of posttranslational modifications. We show that six Cys residues of a precursor peptide are first cyclodehydrated and oxidized to thiazoles in an ordered, but nonlinear fashion that is leader-peptide-dependent. Then four alcohols are glutamylated and converted to alkenes in a C-to-N terminal directional process that is leader-peptide-independent. Finally, two of these alkenes undergo a formal [4 + 2] cycloaddition to form a trithiazole-substituted pyridine macrocycle...
December 7, 2016: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/27697149/limitations-to-photosynthesis-by-proton-motive-force-induced-photosystem-ii-photodamage
#14
Geoffry A Davis, Atsuko Kanazawa, Mark Aurel Schöttler, Kaori Kohzuma, John E Froehlich, A William Rutherford, Mio Satoh-Cruz, Deepika Minhas, Stefanie Tietz, Amit Dhingra, David M Kramer
The thylakoid proton motive force (pmf) generated during photosynthesis is the essential driving force for ATP production; it is also a central regulator of light capture and electron transfer. We investigated the effects of elevated pmf on photosynthesis in a library of Arabidopsis thaliana mutants with altered rates of thylakoid lumen proton efflux, leading to a range of steady-state pmf extents. We observed the expected pmf-dependent alterations in photosynthetic regulation, but also strong effects on the rate of photosystem II (PSII) photodamage...
October 4, 2016: ELife
https://www.readbyqxmd.com/read/27680171/potential-cross-contamination-of-similar-giardia-duodenalis-assemblage-in-children-and-pet-dogs-in-southern-brazil-as-determined-by-pcr-rflp
#15
Rosiléia Marinho de Quadros, Paulo Henrique Exterchoter Weiss, Sandra Marcia Tietz Marques, Luiz Claudio Miletti
Giardia duodenalis is an enteric parasite that has distinct genetic groups. Human infections are mainly caused by assemblages A and B, although sporadic infections by assemblages C and D have also been reported. Animals can be infected by a wide range of assemblages (A to H). The aim of this study is to identify the assemblages and sub-assemblages of G. duodenalis with zoonotic features in fecal samples of school-aged children, and in dogs that coexist in the same households in Lages, Santa Catarina, Brazil...
2016: Revista do Instituto de Medicina Tropical de São Paulo
https://www.readbyqxmd.com/read/27604145/tietz-waardenburg-type-2a-syndrome-associated-with-posterior-microphthalmos-in-two-unrelated-patients-with-novel-mitf-gene-mutations
#16
Vianney Cortés-González, Juan Carlos Zenteno, Martín Guzmán-Sánchez, Verónica Giordano-Herrera, Dalia Guadarrama-Vallejo, Narlly Ruíz-Quintero, Cristina Villanueva-Mendoza
Tietz syndrome and Waardenburg syndrome type 2A are allelic conditions caused by MITF mutations. Tietz syndrome is inherited in an autosomal dominant pattern and is characterized by congenital deafness and generalized skin, hair, and eye hypopigmentation, while Waardenburg syndrome type 2A typically includes variable degrees of sensorineural hearing loss and patches of de-pigmented skin, hair, and irides. In this paper, we report two unrelated families with MITF mutations. The first family showed an autosomal dominant pattern and variable expressivity...
September 8, 2016: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/27581090/morphologic-features-of-basal-cell-carcinoma-using-the-en-face-mode-in-frequency-domain-optical-coherence-tomography
#17
T von Braunmühl, D Hartmann, J K Tietze, D Cekovic, C Kunte, T Ruzicka, C Berking, E C Sattler
BACKGROUND: Optical coherence tomography (OCT) has become a valuable non-invasive tool in the in vivo diagnosis of non-melanoma skin cancer, especially of basal cell carcinoma (BCC). Due to an updated software-supported algorithm, a new en-face mode - similar to the horizontal en-face mode in high-definition OCT and reflectance confocal microscopy - surface-parallel imaging is possible which, in combination with the established slice mode of frequency domain (FD-)OCT, may offer additional information in the diagnosis of BCC...
November 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27576323/simulation-of-developing-human-neuronal-cell-networks
#18
Kerstin Lenk, Barbara Priwitzer, Laura Ylä-Outinen, Lukas H B Tietz, Susanna Narkilahti, Jari A K Hyttinen
BACKGROUND: Microelectrode array (MEA) is a widely used technique to study for example the functional properties of neuronal networks derived from human embryonic stem cells (hESC-NN). With hESC-NN, we can investigate the earliest developmental stages of neuronal network formation in the human brain. METHODS: In this paper, we propose an in silico model of maturating hESC-NNs based on a phenomenological model called INEX. We focus on simulations of the development of bursts in hESC-NNs, which are the main feature of neuronal activation patterns...
August 30, 2016: Biomedical Engineering Online
https://www.readbyqxmd.com/read/27553506/separation-of-ballistic-and-diffusive-fluorescence-photons-in-confocal-light-sheet-microscopy-of-arabidopsis-roots
#19
Tobias Meinert, Olaf Tietz, Klaus J Palme, Alexander Rohrbach
Image quality in light-sheet fluorescence microscopy is strongly affected by the shape of the illuminating laser beam inside embryos, plants or tissue. While the phase of Gaussian or Bessel beams propagating through thousands of cells can be partly controlled holographically, the propagation of fluorescence light to the detector is difficult to control. With each scatter process a fluorescence photon loses information necessary for the image generation. Using Arabidopsis root tips we demonstrate that ballistic and diffusive fluorescence photons can be separated by analyzing the image spectra in each plane without a priori knowledge...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27529991/simultaneous-occurrence-of-salmonella-enterica-campylobacter-spp-and-yersinia-enterocolitica-along-the-pork-production-chain-from-farm-to-meat-processing-in-five-conventional-fattening-pig-herds-in-lower-saxony
#20
Jana-Kristin Niemann, Thomas Alter, Greta Gölz, Erhard Tietze, Angelika Fruth, Wolfgang Rabsch, Christiane von Münchhausen, Roswitha Merle, Lothar Kreienbrock
The objectives of this study were to gather data on the occurrence of Salmonella (S.) enterica, Campylobacter spp. and Yersinia (Y.) enterocolitica along the pork production chain and to further analyze detected Salmonella isolates by additionally applying MLVA (multiple-locus variable-number tandem repeat analysis). In total, 336 samples were collected at primary production, slaughter and meat processing from five conventional fattening pig farms and one common slaughterhouse. At farm level, S. enterica, Campylobacter spp...
July 2016: Berliner und Münchener Tierärztliche Wochenschrift
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