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https://www.readbyqxmd.com/read/28298040/noninvasive-assessment-of-isocitrate-dehydrogenase-mutation-status-in-cerebral-gliomas-by-magnetic-resonance-spectroscopy-in-a-clinical-setting
#1
Anna Tietze, Changho Choi, Bruce Mickey, Elizabeth A Maher, Benedicte Parm Ulhøi, Ryan Sangill, Yasmin Lassen-Ramshad, Slavka Lukacova, Leif Østergaard, Gorm von Oettingen
OBJECTIVE Mutations in the isocitrate dehydrogenase (IDH) genes are of proven diagnostic and prognostic significance for cerebral gliomas. The objective of this study was to evaluate the clinical feasibility of using a recently described method for determining IDH mutation status by using magnetic resonance spectroscopy (MRS) to detect the presence of 2-hydroxyglutarate (2HG), the metabolic product of the mutant IDH enzyme. METHODS By extending imaging time by 6 minutes, the authors were able to include a point-resolved spectroscopy (PRESS) MRS sequence in their routine glioma imaging protocol...
March 3, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28290206/diverse-applications-of-nanomedicine
#2
Beatriz Pelaz, Christoph Alexiou, Ramon A Alvarez-Puebla, Frauke Alves, Anne M Andrews, Sumaira Ashraf, Lajos P Balogh, Laura Ballerini, Alessandra Bestetti, Cornelia Brendel, Susanna Bosi, Monica Carril, Warren C W Chan, Chunying Chen, Xiaodong Chen, Xiaoyuan Chen, Zhen Cheng, Daxiang Cui, Jianzhong Du, Christian Dullin, Alberto Escudero, Neus Feliu, Mingyuan Gao, Michael George, Yury Gogotsi, Arnold Grünweller, Zhongwei Gu, Naomi J Halas, Norbert Hampp, Roland K Hartmann, Mark C Hersam, Patrick Hunziker, Ji Jian, Xingyu Jiang, Philipp Jungebluth, Pranav Kadhiresan, Kazunori Kataoka, Ali Khademhosseini, Jindřich Kopeček, Nicholas A Kotov, Harald F Krug, Dong Soo Lee, Claus-Michael Lehr, Kam W Leong, Xing-Jie Liang, Mei Ling Lim, Luis M Liz-Marzán, Xiaowei Ma, Paolo Macchiarini, Huan Meng, Helmuth Möhwald, Paul Mulvaney, Andre E Nel, Shuming Nie, Peter Nordlander, Teruo Okano, Jose Oliveira, Tai Hyun Park, Reginald M Penner, Maurizio Prato, Victor Puntes, Vincent M Rotello, Amila Samarakoon, Raymond E Schaak, Youqing Shen, Sebastian Sjöqvist, Andre G Skirtach, Mahmoud G Soliman, Molly M Stevens, Hsing-Wen Sung, Ben Zhong Tang, Rainer Tietze, Buddhisha N Udugama, J Scott VanEpps, Tanja Weil, Paul S Weiss, Itamar Willner, Yuzhou Wu, Lily Yang, Zhao Yue, Qian Zhang, Qiang Zhang, Xian-En Zhang, Yuliang Zhao, Xin Zhou, Wolfgang J Parak
The design and use of materials in the nanoscale size range for addressing medical and health-related issues continues to receive increasing interest. Research in nanomedicine spans a multitude of areas, including drug delivery, vaccine development, antibacterial, diagnosis and imaging tools, wearable devices, implants, high-throughput screening platforms, etc. using biological, nonbiological, biomimetic, or hybrid materials. Many of these developments are starting to be translated into viable clinical products...
March 14, 2017: ACS Nano
https://www.readbyqxmd.com/read/28244986/a-new-genome-mining-tool-redefines-the-lasso-peptide-biosynthetic-landscape
#3
Jonathan I Tietz, Christopher J Schwalen, Parth S Patel, Tucker Maxson, Patricia M Blair, Hua-Chia Tai, Uzma I Zakai, Douglas A Mitchell
Ribosomally synthesized and post-translationally modified peptide (RiPP) natural products are attractive for genome-driven discovery and re-engineering, but limitations in bioinformatic methods and exponentially increasing genomic data make large-scale mining of RiPP data difficult. We report RODEO (Rapid ORF Description and Evaluation Online), which combines hidden-Markov-model-based analysis, heuristic scoring, and machine learning to identify biosynthetic gene clusters and predict RiPP precursor peptides...
February 28, 2017: Nature Chemical Biology
https://www.readbyqxmd.com/read/28242504/the-proportion-of-circulating-cd45ro-cd8-memory-t-cells-is-correlated-with-clinical-response-in-melanoma-patients-treated-with-ipilimumab
#4
Julia K Tietze, Daniela Angelova, Markus V Heppt, Markus Reinholz, William J Murphy, Michael Spannagl, Thomas Ruzicka, Carola Berking
BACKGROUND: Immune checkpoint blockade (ICB) has been a breakthrough in the treatment of metastatic melanoma. But with only about 20-40% long-term responders and severe side-effects in about 12-17%, finding predictive markers for treatment response is of great interest. METHODS: We prospectively assessed clinical data, haematologic parameters and freshly isolated peripheral blood mononuclear cells of 30 patients treated with ipilimumab (n = 21) and pembrolizumab (n = 9) prior to the first 4 cycles with ICB and before the first tumour assessment...
February 24, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28215874/first-paleoparasitological-record-of-digenean-eggs-from-a-native-deer-from-patagonia-argentina-cueva-parque-diana-archaeological-site
#5
Beltrame María Ornela, Tietze Eleonor, Pérez Alberto Enrique, Sardella Norma Haydeé
Eggs representative of a digenean species were found in coprolites belonged to an endemic deer from Patagonia. Samples were collected from the archaeological site named "Cueva Parque Diana". This site is a cave located at the Lanín National Park, Neuquén Province, Argentina. The coprolites were dated from 2370±70 to 580±60 years B.P. The eggs were ellipsoidal, operculated, yellowish and thin-shelled. Measurements (n=65) ranged from 120.0 to 142.5 (133.2±6.53) μm long and 62.5 to 87.5 (72.6±6.15) μm wide...
February 15, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28177212/amorphous-tin-oxide-as-a-low-temperature-processed-electron-transport-layer-for-organic-and-hybrid-perovskite-solar-cells
#6
Jérémy Barbé, Max L Tietze, Marios Neophytou, Banavoth Murali, Erkki Alarousu, Abdulrahman El Labban, Mutalifu Abulikemu, Wan Yue, Omar F Mohammed, Iain McCulloch, Aram Amassian, Silvano Del Gobbo
Chemical bath deposition (CBD) of tin oxide (SnO2) thin films as an electron-transport layer (ETL) in a planar-heterojunction n-i-p organohalide lead perovskite and organic bulk-heterojunction (BHJ) solar cells is reported. The amorphous SnO2 (a-SnO2) films are grown from a nontoxic aqueous bath of tin chloride at a very low temperature (55 °C) and do not require postannealing treatment to work very effectively as an ETL in a planar-heterojunction n-i-p organohalide lead perovskite or organic BHJ solar cells, in lieu of the commonly used ETL materials titanium oxide (TiO2) and zinc oxide (ZnO), respectively...
March 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28120501/enantioselective-total-synthesis-and-structure-confirmation-of-the-natural-dimeric-tetrahydroxanthenone-dicerandrol%C3%A2-c
#7
Dhandapani Ganapathy, Johannes R Reiner, Guillermo Valdomir, Soundararasu Senthilkumar, Lutz F Tietze
The first enantioselective total synthesis of natural dicerandrol C (1 c) as its enantiomer containing a dimeric tetrahydroxanthenone skeleton is described starting from the enantiopure chromane 6 which was obtained through a Wacker-type cyclization with >99 % ee. For the formation of the dimeric skeleton a palladium-catalyzed Suzuki reaction was used. The synthesis allowed the confirmation of the absolute configuration of the dicerandrols.
January 25, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28097925/improving-cancer-imaging-with-magnetic-nanoparticles-where-are-we-now
#8
Rainer Tietze, Christoph Alexiou
No abstract text is available yet for this article.
January 18, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28097592/-mycoses-of-the-skin
#9
Hans-Jürgen Tietz
No abstract text is available yet for this article.
January 2017: MMW Fortschritte der Medizin
https://www.readbyqxmd.com/read/28063356/nanoparticles-for-radiooncology-mission-vision-challenges
#10
REVIEW
Leoni A Kunz-Schughart, Anna Dubrovska, Claudia Peitzsch, Alexander Ewe, Achim Aigner, Samuel Schellenburg, Michael H Muders, Silke Hampel, Giuseppe Cirillo, Francesca Iemma, Rainer Tietze, Christoph Alexiou, Holger Stephan, Kristof Zarschler, Orazio Vittorio, Maria Kavallaris, Wolfgang J Parak, Lutz Mädler, Suman Pokhrel
Cancer is one of the leading non-communicable diseases with highest mortality rates worldwide. About half of all cancer patients receive radiation treatment in the course of their disease. However, treatment outcome and curative potential of radiotherapy is often impeded by genetically and/or environmentally driven mechanisms of tumor radioresistance and normal tissue radiotoxicity. While nanomedicine-based tools for imaging, dosimetry and treatment are potential keys to the improvement of therapeutic efficacy and reducing side effects, radiotherapy is an established technique to eradicate the tumor cells...
December 14, 2016: Biomaterials
https://www.readbyqxmd.com/read/28055267/microstructural-changes-in-the-thalamus-after-mild-traumatic-brain-injury-a-longitudinal-diffusion-and-mean-kurtosis-tensor-mri-study
#11
Erhard Trillingsgaard Næss-Schmidt, Jakob Udby Blicher, Simon Fristed Eskildsen, Anna Tietze, Brian Hansen, Peter William Stubbs, Sune Jespersen, Leif Østergaard, Jørgen Feldbæk Nielsen
PRIMARY OBJECTIVE: The primary aim of this study was to assess microstructural changes in the thalamus, hippocampus and corpus callosum with a fast mean kurtosis tensor (MKT) technique, in the acute and sub-acute phase after mTBI. It was hypothesized that MKT would differ between baseline and follow-up in patients. The secondary aim was to relate diffusion measures to symptoms of mTBI. RESEARCH DESIGN: A longitudinal case-control study. METHODS AND PROCEDURES: Twenty-seven patients with mTBI and 27 age- and gender-matched healthy controls were enrolled in the study...
2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/28024217/optimized-procedures-for-manganese-52-production-separation-and-radiolabeling
#12
Jesper Fonslet, Sabrina Tietze, Andreas I Jensen, Stephen A Graves, Gregory W Severin
Pressed chromium-powder cyclotron targets were irradiated with 16MeV protons, producing (52)Mn with average yields of 6.2±0.8MBq/µAh. Separation by solid-phase anion exchange from ethanol-HCl mixtures recovered 94.3±1.7% of (52)Mn and reduced the chromium content by a factor of 2.2±0.4×10(5). An additional AG 1-X8 column was used to remove copper, iron, cobalt and zinc impurities from the prepared (52)Mn in 8M HCl. The macrocyclic chelator DOTA was rapidly radiolabeled with (52)Mn in aq. ammonium acetate (pH 7...
March 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/27916464/subtype-specific-block-of-voltage-gated-k-channels-by-%C3%AE-conopeptides
#13
Enrico Leipold, Florian Ullrich, Markus Thiele, Alesia A Tietze, Heinrich Terlau, Diana Imhof, Stefan H Heinemann
The neurotoxic cone snail peptide μ-GIIIA specifically blocks skeletal muscle voltage-gated sodium (NaV1.4) channels. The related conopeptides μ-PIIIA and μ-SIIIA, however, exhibit a wider activity spectrum by also inhibiting the neuronal NaV channels NaV1.2 and NaV1.7. Here we demonstrate that those μ-conopeptides with a broader target range also antagonize select subtypes of voltage-gated potassium channels of the KV1 family: μ-PIIIA and μ-SIIIA inhibited KV1.1 and KV1.6 channels in the nanomolar range, while being inactive on subtypes KV1...
January 22, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27902858/reliable-estimation-of-microvascular-flow-patterns-in-patients-with-disrupted-blood-brain-barrier-using-dynamic-susceptibility-contrast-mri
#14
Mikkel Bo Hansen, Anna Tietze, Jayashree Kalpathy-Cramer, Elizabeth R Gerstner, Tracy T Batchelor, Leif Østergaard, Kim Mouridsen
PURPOSE: To present and quantify the performance of a method to compute tissue hemodynamic parameters from dynamic susceptibility contrast (DSC) MRI data in brain tissue with possible nonintact blood-brain barrier. THEORY AND MATERIALS AND METHODS: We propose a Bayesian scheme to obtain perfusion metrics, including capillary transit-time heterogeneity (CTH), from DSC-MRI data in the presence of contrast agent extravasation. Initial performance assessment is performed through simulations...
November 30, 2016: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/27892653/low-baseline-levels-of-nk-cells-may-predict-a-positive-response-to-ipilimumab-in-melanoma-therapy
#15
Julia K Tietze, Daniela Angelova, Markus V Heppt, Thomas Ruzicka, Carola Berking
The introduction of immune checkpoint blockade (ICB) has been a breakthrough in the therapy of metastatic melanoma. The influence of ICB on T-cell populations has been studied extensively, but little is known about the effect on NK cells. In this study, we analysed the relative and absolute amounts of NK cells and of the subpopulations of CD56(dim) and CD56(bright) NK cells among the peripheral blood mononuclear cells (PBMCs) of 32 patients with metastatic melanoma before and under treatment with ipilimumab or pembrolizumab by flow cytometry...
November 28, 2016: Experimental Dermatology
https://www.readbyqxmd.com/read/27828971/development-of-a-bioinformatics-framework-for-the-detection-of-gene-conversion-and-the-analysis-of-combinatorial-diversity-in-immunoglobulin-heavy-chains-in-four-cattle-breeds
#16
Stefanie Walther, Manfred Tietze, Claus-Peter Czerny, Sven König, Ulrike S Diesterbeck
We have developed a new bioinformatics framework for the analysis of rearranged bovine heavy chain immunoglobulin (Ig) variable regions by combining and refining widely used alignment algorithms. This bioinformatics framework allowed us to investigate alignments of heavy chain framework regions (FRHs) and the separate alignments of FRHs and heavy chain complementarity determining regions (CDRHs) to determine their germline origin in the four cattle breeds Aubrac, German Black Pied, German Simmental, and Holstein Friesian...
2016: PloS One
https://www.readbyqxmd.com/read/27797509/targeting-reactive-carbonyls-for-identifying-natural-products-and-their-biosynthetic-origins
#17
Tucker Maxson, Jonathan I Tietz, Graham A Hudson, Xiao Rui Guo, Hua-Chia Tai, Douglas A Mitchell
Natural products (NPs) serve important roles as drug candidates and as tools for chemical biology. However, traditional NP discovery, largely based on bioassay-guided approaches, is biased toward abundant compounds and rediscovery rates are high. Orthogonal methods to facilitate discovery of new NPs are thus needed, and herein we describe an isotope tag-based expansion of reactivity-based NP screening to address these shortcomings. Reactivity-based screening is a directed discovery approach in which a specific reactive handle on the NP is targeted by a chemoselective probe to enable its detection by mass spectrometry...
November 23, 2016: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/27710977/the-systemic-management-of-advanced-melanoma-in-2016
#18
REVIEW
Markus V Heppt, Cecilia Dietrich, Saskia A Graf, Thomas Ruzicka, Julia K Tietze, Carola Berking
Melanoma is a common type of skin cancer with a high propensity to metastasize. Tyrosine kinase inhibitors targeting the mitogen-activated protein kinase (MAPK) pathway and immune checkpoint blockade have recently revolutionized the management of unresectable and metastatic disease. However, acquired resistance and primary non-response to therapy require novel treatment strategies and combinations. The purpose of this review is to provide a brief and up-to-date overview on the clinical management and current trial landscape in melanoma...
2016: Oncology Research and Treatment
https://www.readbyqxmd.com/read/27705891/comparison-of-percutaneous-closure-versus-surgical-femoral-cutdown-for-decannulation-of-large-sized-arterial-and-venous-access-sites-in-adults-after-successful-weaning-of-veno-arterial-extracorporeal-membrane-oxygenation
#19
Nicolas Majunke, Norman Mangner, Axel Linke, Enno Boudriot, Sandra Erbs, Franziska Tietz, Sabrina Wolff, Stephan Schürer, Gerhard Schuler, Marcus Sandri
OBJECTIVE: Surgical femoral cutdown for decannulation after veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is considered standard practice. However, access-site complications with this technique are not rare. The objective of this study is to evaluate feasibility, safety, and efficacy of a complete percutaneous decannulation procedure after VA-ECMO compared with the conventional surgical cutdown approach. METHODS: In 35 patients who were successfully weaned from VA-ECMO support, femoral artery and vein access sites were closed using a completely percutaneous approach in 15 patients, whereas 20 patients had conventional surgical cutdown for access-site closure...
October 2016: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/27700071/biosynthetic-timing-and-substrate-specificity-for-the-thiopeptide-thiomuracin
#20
Zhengan Zhang, Graham A Hudson, Nilkamal Mahanta, Jonathan I Tietz, Wilfred A van der Donk, Douglas A Mitchell
The biosynthesis of the thiopeptide thiomuracin is a well-orchestrated process involving a multitude of posttranslational modifications. We show that six Cys residues of a precursor peptide are first cyclodehydrated and oxidized to thiazoles in an ordered, but nonlinear fashion that is leader-peptide-dependent. Then four alcohols are glutamylated and converted to alkenes in a C-to-N terminal directional process that is leader-peptide-independent. Finally, two of these alkenes undergo a formal [4 + 2] cycloaddition to form a trithiazole-substituted pyridine macrocycle...
December 7, 2016: Journal of the American Chemical Society
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