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Dandan Ju, Feng Song, Yingdong Han, Wenjing Cui, Aihua Zhou, Shujing Liu, Xueqin Wang, Ming Feng, Chengguo Ming
We synthesized the uniform core-shell microstructured compounds with hexagonal phase NaYF₄:Er/Yb microrods as the core and hexagonal phase NaLnF₄ (NaYbF₄, NaLuF₄:Yb/Tm, NaYF₄:Yb/Er, NaYF₄:Eu) as the shell based on the hydrothermal reaction. These microscale core-shell structures provided a platform for the spatially confining optical process while possessing high luminescence efficiency. The thickness of the shell could be controlled by adjusting the amounts of shell precursor, which significantly affected the intensity of the shell dopant ions emission and the emission color of core-shell upconversion luminescence (UCL)...
December 14, 2017: Nanomaterials
Katherine A Benavides, Iain W H Oswald, Julia Y Chan
The discovery of novel magnetic and electronic properties in low-dimensional materials has led to the pursuit of hierarchical materials with specific substructures. Low-dimensional solids are highly anisotropic by nature and show promise in new quantum materials leading to exotic physical properties not realized in three-dimensional materials. We have the opportunity to extend our synthetic strategy of the flux-growth method to designing single crystalline low-dimensional materials in bulk. The goal of this Account is to highlight the synthesis and physical properties of several low-dimensional intermetallic compounds containing specific structural motifs that are linked to desirable magnetic and electrical properties...
December 14, 2017: Accounts of Chemical Research
Fuminori Sonohara, Feng Gao, Naoki Iwata, Mitsuro Kanda, Masahiko Koike, Naoki Takahashi, Yasuhide Yamada, Yasuhiro Kodera, Xin Wang, Ajay Goel
OBJECTIVE: This study aimed to develop a gene-expression signature for identification of lymph node (LN) metastasis in esophageal squamous cell carcinoma (ESCC) patients. SUMMARY OF BACKGROUND DATA: LN metastasis is recognized as the most important independent risk factor for therapeutic decision-making of ESCC patients. METHODS: A bioinformatic approach was used to analyze RNA sequencing profiles of ESCC patients, and to develop a gene-expression signature for identifying LN metastasis...
December 12, 2017: Annals of Surgery
Workineh Torben, Adebayo J Molehin, Robert V Blair, Carys Kenway, Faith Shiro, Davis Roslyn, Bayissa Chala, Dereje Gutu, Michael A Kebede, Gul Ahmad, Weidong Zhang, Pyone Aye, Mahesh Mohan, Andrew Lackner, Afzal A Siddiqui
A reduction in the burden of schistosomiasis is potentially achievable by integrating a schistosomiasis vaccine with current control measures. Here, we determine parasite-specific in vitro responses of B, T, and NK cells from naive uninfected rhesus macaques to Schistosoma mansoni (Sm) egg (SmEA) and worm antigen (SmWA) preparations isolated from infected baboons. Pronounced B cell responses to SmEA and NK cell responses to both SmEA and SmWA were observed. High levels of IL-2 and IL-21 responses against Sm antigens were observed in T and non-T cells of lymph nodes (LNs) and gut lamina propria-derived lymphocytes (LPLs)...
November 2017: Annals of the New York Academy of Sciences
Jing Wang, Ping Cao, Yuan-Yuan Qi, Xue-Ping Chen, Li Ma, Rong-Rong Deng, Li-Li Zhang, Yu Zhao
OBJECTIVE: This study aims to evaluate the role of FEN1 E160D mutation in lupus nephritis (LN) patients with cell apoptosis dysfunction. METHODS: (1) Cell apoptosis was detected from 50 paraffin samples obtained from renal biopsies of patients with Class IV LN by TUNEL method and the relationship of the systemic lupus erythematosus disease activity index 2000 (SLEDAI 2000) and renal tissue cell apoptotic index (AI) was discussed. (2) FEN1 gene 61563142-61563342 containing E160D were analysed by extracting genomic DNA from peripheral blood collected from the above 50 LN patients and 25 patients with nephrectomy caused by renal trauma...
December 2017: Autoimmunity
Sean Williams, Thomas Booton, Matthew Watson, Daniel Rowland, Marco Altini
Heart rate variability (HRV) is a popular tool for monitoring training adaptation and readiness in athletes, but it also has the potential to indicate early signs of somatic tissue overload prior to the onset of pain or fully developed injury. Therefore, the aim of this study was to investigate the interaction between HRV, workloads, and risk of overuse problems in competitive CrossFit™ athletes. Daily resting HRV and workloads (duration × session-RPE) were recorded in six competitive CrossFit™ athletes across a 16 week period...
December 2017: Journal of Sports Science & Medicine
Pin-Wen Huang, Cong-Zhi Wang, Qun-Yan Wu, Jian-Hui Lan, Gang Song, Zhi-Fang Chai, Wei-Qun Shi
Separation of trivalent actinides (An(iii)) and lanthanides (Ln(iii)) in spent nuclear fuel reprocessing is extremely challenging mainly owing to their similar chemical properties. Two amine-type reagents, tetrakis(2-pyridyl-methyl)-1,2-ethylenediamine (TPEN) and its hydrophobic derivative N,N,N',N'-tetrakis((4-butoxypyridin-2-yl)methyl)-ethylenediamine (TBPEN), have been identified to possess a selectivity for Am(iii) over Eu(iii). In this work, the structures, bonding nature, and thermodynamic behaviors of the Am(iii) and Eu(iii) complexes with these two ligands have been systematically studied via scalar relativistic density functional theory (DFT) calculations...
December 13, 2017: Physical Chemistry Chemical Physics: PCCP
Bo Zhou, Junfang Deng, Lifeng Chen, Shusen Zheng
The lymph node (LN) status is very important for the survival in pancreatic neuroendocrine tumors (PNETs). Therefore, the investigation of factors related to LN metastases has a great clinical significance. The aim of this study was to evaluate the predictive value of the preoperative neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and possible clinical parameters on the LN metastases in nonfunctional PNETs (NF-PNETs). A retrospective review of 101 NF-PNET patients following curative resection and lymphadenectomy was conducted...
December 13, 2017: Scientific Reports
Tao Wang, Xuelin Zhou, Honghong Liu, Jiabo Wang, Ping Zhang, Yun Zhu, Kun Li, Shizhang Wei, Haotian Li, Lifu Wang, Ruilin Wang, Yanling Zhao
Fuzheng Huayu (FZHY) capsule, a formulated traditional Chinese medicine product with 6 Chinese herbs, is widely used for HBV-related cirrhosis as an adjuvant treatment. However, the efficacy of FZHY capsule for HBV-induced cirrhosis did not be comprehensively proved by systematic analysis. Our current analysis was aimed to assess the efficacy and safety of FZHY capsule by an evidence-based method. Databases, including China National Knowledge Infrastructure, Wangfang, VIP medicine information system, Pubmed, Embase, and Cochrane Library, were searched, and the randomized controlled trials of FZHY capsule were used for the treatment of HBV-associated liver cirrhosis...
December 13, 2017: Phytotherapy Research: PTR
Marta Amaro da Silveira Duval, André Borsatto Zanella, Ana Patrícia Cristo, Carlo Sasso Faccin, Marcia Silva Graudenz, Ana Luiza Maia
Background: Thyroglobulin measurements in the washout of fine needle aspiration (FNA-Tg) are an excellent tool to detect lymph node (LN) metastases of differentiated thyroid carcinoma (DTC). Nevertheless, how to define the best cutoffs and the influence of potential confounders are still being discussed. Objective: To evaluate the accuracy of FNA-Tg measurement to detect DTC metastases and the influence of thyroid status and anti-thyroglobulin antibodies (TgAb)...
November 2017: European Thyroid Journal
Mohannad Hosny, Bhavan Rai, Feras Aljaafari, Samita Agarwal, Thomas McNicholas, Gregory Boustead, Thimothy Lane, James Adshead, Nikhil Vasdev
Objectives: Traditionally anterior prostatic fat (APF) hasn't been included in pelvic lymph node (LN) dissection templates following radical prostatectomy. In this study we evaluate the incidence of lymphoid tissue in the APF and the incidence of LN metastasis in APF in patients who have undergone robotic-assisted laparoscopic radical prostatectomy (RALP). Methods: A prospective database of RALP has been maintained between January 2010 and September 2015. APF is routinely excised and sent separately for histopathological evaluation to identify lymphoid tissue and metastatic prostate cancer...
November 2017: Current Urology
Wonguen Jung, Kyung Ran Park, Kyung-Ja Lee, Kyubo Kim, Jihae Lee, Songmi Jeong, Yi-Jun Kim, Jiyoung Kim, Hai-Jeon Yoon, Byung-Chul Kang, Hae Soo Koo, Sun Hee Sung, Min-Sun Cho, Sanghui Park
Purpose: To evaluate the diagnostic accuracy of computed tomography (CT), magnetic resonance imaging (MRI), and positron emission tomography/computed tomography (PET/CT) in predicting pelvic lymph node (LN) metastases in patients with cervical cancer. Materials and Methods: From January 2009 to March 2015, 114 patients with FIGO stage IA1-IIB uterine cervical cancer who underwent hysterectomy with pelvic lymphadenectomy and took CT, MRI, and PET/CT before surgery were enrolled in this study...
December 15, 2017: Radiation Oncology Journal
Shuichi Morizane, Masashi Honda, Satoshi Fukasawa, Atsushi Komaru, Junichi Inokuchi, Masatoshi Eto, Masaki Shimbo, Kazunori Hattori, Yoshiaki Kawano, Atsushi Takenaka
BACKGROUND: We conducted a retrospective study to compare the perioperative course and lymph node (LN) counts of patients undergoing limited pelvic lymphadenectomy (lPLND) or extended pelvic lymphadenectomy (ePLND) during robot-assisted radical prostatectomy in an initial Japanese series. METHODS: The cohort included 1333 patients who underwent either lPLND (n = 902) or ePLND (n = 431) during robot-assisted radical prostatectomy at five institutions in Japan...
December 11, 2017: International Journal of Clinical Oncology
Chunliang Shang, Wei Wang, Yuandong Liao, Yili Chen, Tianyu Liu, Qiqiao Du, Jiaming Huang, Yanchun Liang, Junxiu Liu, Yunhe Zhao, Luyan Guo, Zheng Hu, Shuzhong Yao
Cancer spread to lymph nodes (LN) predicts poor survival but underlying mechanisms remain little understood. In this study, we show that overexpression of the long non-coding RNA LNMICC associates with LN metastasis of primary cervical cancer, where it serves as an independent high-risk factor in patient survival. Functional investigations demonstrated that LNMICC promoted LN metastasis by reprogramming fatty acid metabolism, by recruiting the nuclear factor NPM1 to the promoter of the fatty acid binding protein FABP5...
December 11, 2017: Cancer Research
Bochao Zhao, Jingting Zhang, Jiale Zhang, Xiuxiu Chen, Junqing Chen, Zhenning Wang, Huimian Xu, Baojun Huang
BACKGROUND: Although the numeric-based lymph node (LN) staging was widely used in the worldwide, it did not represent the anatomical location of metastatic lymph nodes (MLNs) and not reflect extent of LN dissection. Therefore, in the present study, we investigated whether the anatomical location of MLNs was still necessary to evaluate the prognosis of node-positive gastric cancer (GC) patients. METHODS: We reviewed 1451 GC patients who underwent radical gastrectomy in our institution between January 1986 and January 2008...
December 11, 2017: Scandinavian Journal of Gastroenterology
Yang Yang, Meihua Gao, Zhenhua Lin, Liyan Chen, Yu Jin, Guang Zhu, Yixuan Wang, Tiefeng Jin
Triple-negative breast cancer (TNBC) is a highly aggressive subtype of breast cancer associated with poor prognosis. As an oncogene, DEK involves in regulation of various cellular metabolisms and plays an important role in tumor growth and progression. Increasing evidences suggested that abnormal expression of DEK is closely related to multiple malignant tumors. However, the possible involvement of DEK in epithelial to mesenchymal transition (EMT) and angiogenesis in TNBC remains unclear. In the present study, we revealed that the over-expression of DEK was significantly correlated with clinical stage, differentiation, and lymph node (LN) metastasis of TNBC and indicated poor overall survival of TNBC patients...
November 17, 2017: Oncotarget
Zhichao Wang, Haizhou Li, Xinyang Liu, Jinhong Bae, Xin Huang, Yashan Gao, Xiangwen Xu, Jihan Guo, Lin Lu, Tao Zan, Qingfeng Li
Background: Ultrathin melanoma was previously demonstrated to have higher risk for melanoma-specific mortality using SEER database. However, these guideline-changing conclusions has been recently challenged by miscoding of thickness. This present study was performed to assess the prognosis of thin and ultrathin melanoma using only surgically-treated, pathologically confirmed and after removal of discordant cases. Methods: Melanoma patients from SEER database who were initially diagnosed with histologically confirmed and surgically treated melanoma from 1998 to 2012 were included...
November 17, 2017: Oncotarget
Jun Wang, Qiang-Sheng Zhang, Wei Dou, Alexander M Kirillov, Wei-Sheng Liu, Cong Xu, Cai-Ling Xu, Ran Fang, Li-Zi Yang
A trifunctional aromatic building block (H2L) containing three different types of functional groups (carboxyl C([double bond, length as m-dash]O)OH, aldehyde C([double bond, length as m-dash]O)H, and O-ether) was applied for the hydrothermal synthesis of two novel lanthanide 2D coordination polymers [Ln(μ-HL)(μ3-L)(phen)]n {Ln = Tb (1) and Eu (2); H2L = 5-methoxy-(4-benzaldehyde)-1,3-benzene dicarboxylic acid; phen = 1,10-phenanthroline}. Both compounds 1 and 2 are isostructural and reveal very complicated 2D metal-organic double layers with the 3,4L27 topology...
December 11, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
Dmitry M Lyubov, Anton V Cherkasov, Georgy K Fukin, Konstantin A Lyssenko, Elena A Rychagova, Sergey Yu Ketkov, Alexander A Trifonov
Lithium silylamides 1,8-C10H6[N(SiMe3)Li(L)]2 (L = Et2O (); L = TMEDA (1TMEDA)), when treated with PhC[triple bond, length as m-dash]N, formed the adducts 1,8-C10H6[N(SiMe3)Li(N[triple bond, length as m-dash]CPh)(OEt2)][N(SiMe3)Li(OEt2)] () and 1,8-C10H6[N(SiMe3)Li(N[triple bond, length as m-dash]CPh)][N(SiMe3)Li(TMEDA)] (2TMEDA) containing one benzonitrile molecule coordinated to Li ion while the second molecule retains a coordinated L ligand. The salt metathesis reactions of LnCl3 (Ln = Y, Sm) with equimolar amounts of and 2TMEDA (THF, 4 h, 40 °C) resulted in benzonitrile insertion and formation of new dianionic amido-amidinate ligands...
December 11, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
Shizuyo Tsujimura, Tomoko Adachi, Kazuyoshi Saito, Yoshiya Tanaka
Introduction: P-glycoprotein (P-gp) expression on activated lymphocytes in systemic lupus erythematosus (SLE) plays a role in active efflux of intracellular drugs, resulting in drug resistance. The role of P-gp-expressing lymphocytes in the pathogenesis of SLE remains unclear. The aim of this study was to determine the importance of P-gp+CD4+ cells in organ manifestations in refractory SLE. Methods: The proportion of P-gp+CD4+ cells was determined by flow cytometry in peripheral blood of patients with SLE (n=116) and healthy adults (n=10)...
2017: RMD Open
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