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https://www.readbyqxmd.com/read/28822118/risk-factors-for-lateral-neck-recurrence-of-n0-n1a-papillary-thyroid-cancer
#1
Yehree Kim, Jong-Lyel Roh, Gyungyup Gong, Kyung-Ja Cho, Seung-Ho Choi, Soon Yuhl Nam, Sang Yoon Kim
BACKGROUND: Current guidelines advocate no prophylactic dissection of the lateral neck compartment for papillary thyroid carcinoma (PTC) without clinical evidence of lateral neck metastasis (cN1b). However, lateral neck recurrence can affect patient treatment outcomes and quality of life. Therefore, this study examined the risk factors for lateral neck recurrence after the definitive treatment of PTC without cN1b. METHODS: The study enrolled 1928 consecutive patients who underwent total thyroidectomy between 2006 and 2012 for PTC without cN1b...
August 18, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28820475/epcam-expression-in-lymph-node-metastases-of-urothelial-cell-carcinoma-of-the-bladder-a-pilot-study
#2
Christa A M van der Fels, Stefano Rosati, Igle J de Jong
In this retrospective pilot study, the feasibility of the epithelial cell adhesion molecule (EpCAM) as an imaging target for lymph node (LN) metastatic disease of urothelial cell carcinoma (UCC) of the bladder was investigated. LN metastases and LNs without metastases of patients who underwent pelvic lymph node dissection because of muscle invasive bladder cancer (MIBC) were used. Primary tumors of the same patients were used from cystectomy specimen, transurethral resections, and biopsies. A pathologist, blinded to clinical data, scored EpCAM immunoreactivity...
August 18, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28820242/expanding-the-scope-of-ligand-substitution-from-m-s2c2ph2-m-ni-2-pd-2-pt-2-to-afford-new-heteroleptic-dithiolene-complexes
#3
Antony Obanda, Kristina Martinez, Russell H Schmehl, Joel T Mague, Igor V Rubtsov, Samantha N MacMillan, Kyle M Lancaster, Stephen Sproules, James P Donahue
The scope of direct substitution of the dithiolene ligand from [M(S2C2Ph2)2] [M = Ni(2+) (1), Pd(2+) (2), Pt(2+) (3)] to produce heteroleptic species [M(S2C2Ph2)2Ln] (n = 1, 2) has been broadened to include isonitriles and dithiooxamides in addition to phosphines and diimines. Collective observations regarding ligands that cleanly produce [M(S2C2Ph2)Ln], do not react at all, or lead to ill-defined decomposition identify soft σ donors as the ligand type capable of dithiolene substitution. Substitution of MeNC from [Ni(S2C2Ph2)(CNMe)2] by L provides access to a variety of heteroleptic dithiolene complexes not accessible from 1...
August 18, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28819789/left-gastric-artery-lymph-nodes-should-be-included-in-d1-lymph-node-dissection-in-gastric-cancer
#4
Naruhiko Ikoma, Mariela Blum, Jeannelyn S Estrella, Xuemei Wang, Keith F Fournier, Paul F Mansfield, Jaffer A Ajani, Brian D Badgwell
BACKGROUND: The Japanese Classification of Gastric Carcinoma includes the left gastric artery (#7) lymph nodes (LNs) in the recommended extent of D1 LN dissection, but this recommendation has not been validated in western institutions. METHODS: We reviewed data from a prospectively maintained database of gastric cancer patients who underwent resection at our academic cancer center and had a separate pathologic assessment of #7 LN in 2005-2016. Risk factors for #7 LN metastases and overall survival were examined by uni- and multivariable analyses...
August 17, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/28819690/conductance-based-refractory-density-approach-comparison-with-experimental-data-and-generalization-to-lognormal-distribution-of-input-current
#5
Anton V Chizhov
The conductance-based refractory density (CBRD) approach is an efficient tool for modeling interacting neuronal populations. The model describes the firing activity of a statistical ensemble of uncoupled Hodgkin-Huxley-like neurons, each receiving individual Gaussian noise and a common time-varying deterministic input. However, the approach requires experimental validation and extension to cases of distributed input signals (or input weights) among different neurons of such an ensemble. Here the CBRD model is verified by comparing with experimental data and then generalized for a lognormal (LN) distribution of the input weights...
August 17, 2017: Biological Cybernetics
https://www.readbyqxmd.com/read/28819535/clinical-features-and-antinuclear-antibodies-profile-among-adults-with-systemic-lupus-erythematosus-and-lupus-nephritis-a-cross-sectional-study
#6
Nashwa Ahmed, Mazin Shigidi, Al Nour Al Agib, Hassan Abdelrahman, Elshafie Taha
INTRODUCTION: Limited data is available regarding the clinical manifestations and pattern of Systemic Lupus Erythematosus (SLE) in Sudan. This study aimed to determine the clinical manifestations and Antinuclear Antibodies (ANA) profile among Sudanese adults with SLE and lupus nephritis (LN). METHODS: A descriptive study was conducted in Omdurman Military Hospital, Sudan. It included all adults with SLE and on regular follow-up during the study period (December 2012 to May 2013)...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28818581/renal-transplantation-in-systemic-lupus-erythematosus-comparison-of-graft-survival-with-other-causes-of-end-stage-renal-disease
#7
Gabriel Horta-Baas, Adolfo Camargo-Coronel, Dafhne Guadalupe Miranda-Hernández, Leslie Gabriela Gónzalez-Parra, María Del Socorro Romero-Figueroa, Mario Pérez-Cristóbal
INTRODUCTION: End-stage renal disease (ESRD) due to lupus nephritis (LN) occurs in 10%-30% of patients. Initially systemic lupus erythematosus (SLE) was a contraindication for kidney transplantation (KT). Today, long-term graft survival remains controversial. Our objective was to compare the survival after KT in patients with SLE or other causes of ESRD. METHODS: All SLE patients who had undergone KT in a retrospective cohort were included. Renal graft survival was compared with that of 50 controls, matched for age, sex, and year of transplantation...
August 14, 2017: Reumatología Clinica
https://www.readbyqxmd.com/read/28816940/signet-ring-cell-carcinoma-of-early-gastric-cancer-is-endoscopic-treatment-really-risky
#8
Sun Hyung Kang, Joo Seok Kim, Hee Seok Moon, Eaum Seok Lee, Seok Hyun Kim, Jae Kyu Sung, Byung Seok Lee, Hyun Yong Jeong
Signet ring cell carcinoma (SRC) is a poorly differentiated cancer of the stomach. Generally, poorly differentiated cancer is believed to show poor prognosis and aggressive behavior. Recently, however, there is debate on the aggressiveness of SRC in early gastric cancer (EGC). We therefore studied postoperation biopsies to investigate the aggressiveness of SRC in EGC.We reviewed medical records of patients with EGC who had surgery from January 2011 to December 2015 in a tertiary hospital in Daejeon, South Korea...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28816405/synthesis-density-functional-theory-calculations-and-luminescence-of-lanthanide-complexes-with-2-6-bis-3-methoxybenzylidene-hydrazinocarbonyl-pyridine-schiff-base-ligand
#9
Ziyad A Taha, Taher S Ababneh, Ahmed K Hijazi, Qutaiba Abu-Salem, Abdulaziz M Ajlouni, Shroq Ebwany
A pyridine-diacylhydrazone Schiff base ligand, L = 2,6-bis[(3-methoxy benzylidene)hydrazinocarbonyl]pyridine was prepared and characterized by single crystal X-ray diffraction. Lanthanide complexes, Ln-L, {[LnL(NO3 )2 ]NO3 .xH2 O (Ln = La, Pr, Nd, Sm, Eu, Gd, Tb, Dy and Er)} were prepared and characterized by elemental analysis, molar conductance, thermal analysis (TGA/DTGA), mass spectrometry (MS), Fourier transform infra-red (FT-IR) and nuclear magnetic resonance (NMR) spectroscopy. Ln-L complexes are isostructural with four binding sites provided by two nitro groups along with four coordination sites for L...
August 17, 2017: Luminescence: the Journal of Biological and Chemical Luminescence
https://www.readbyqxmd.com/read/28816308/ln-iii-complexes-ln-eu-gd-tb-dy-with-a-chiral-ligand-containing-1-10-phenanthroline-and-menthol-fragments-synthesis-structure-magnetic-properties-and-photoluminescence
#10
Stanislav V Larionov, Yuliya A Bryleva, Ludmila A Glinskaya, Victor F Plyusnin, Arkady S Kupryakov, Alexander M Agafontsev, Alexey V Tkachev, Artem S Bogomyakov, Dmitry A Piryazev, Ilya V Korolkov
A series of lanthanide(iii) complexes based on the new chiral ligand L, which contains 1,10-phenanthroline and (-)-menthol fragments, namely [LnL2(NO3)3] (Ln = Eu (1), Gd (2), Tb (3), Dy (4)), have been synthesized and structurally characterized. Complexes 1-4 are isostructural and crystallize in the non-centrosymmetric space group P41212. The mononuclear complexes comprise a 10-coordinate Ln(3+) ion with two bidentate N,N-donor ligands (L) and three bidentate chelating nitrate groups. The magnetic properties of complexes 1-4 are determined mainly by the Ln(3+) ions...
August 17, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28815069/three-field-lymph-node-dissection-in-esophageal-cancer-surgery
#11
REVIEW
Satoru Matsuda, Hiroya Takeuchi, Hirofumi Kawakubo, Yuko Kitagawa
Although multidisciplinary treatment has improved the prognosis of esophageal cancer, it is commonly associated with one of the worse prognoses. Since lymph node (LN) metastases can primarily occur from the cervical to the abdominal field, a strategy for extended LN dissection has been established. The three field LN dissection (3FD) during a transthoracic esophagectomy which is defined as a procedure for cervico-thoraco-abdominal LN dissection, was established in the 1980s' in Japan, and is currently widely accepted throughout the world...
July 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28814837/simulating-clinical-trial-visits-yields-patient-insights-into-study-design-and-recruitment
#12
S Sam Lim, Alan J Kivitz, Doug McKinnell, M Edward Pierson, Faye S O'Brien
PURPOSE: We elicited patient experiences from clinical trial simulations to aid in future trial development and to improve patient recruitment and retention. PATIENTS AND METHODS: Two simulations of draft Phase II and Phase III anifrolumab studies for systemic lupus erythematosus (SLE)/lupus nephritis (LN) were performed involving African-American patients from Grady Hospital, an indigent care hospital in Atlanta, GA, USA, and white patients from Altoona Arthritis and Osteoporosis Center in Altoona, PA, USA...
2017: Patient Preference and Adherence
https://www.readbyqxmd.com/read/28814515/fdg-uptake-in-lymphoid-tissue-serves-as-a-predictor-of-disease-outcome-in-the-nonhuman-primate-model-of-monkeypox-infection
#13
Julie Dyall, Reed F Johnson, Svetlana Chefer, Christopher Leyson, David Thomasson, Jurgen Seidel, Dan R Ragland, Russell Byrum, Catherine Jett, Jennifer A Cann, Marisa St Claire, Elaine Jagoda, Richard C Reba, Dima Hammoud, Joseph E Blaney, Peter B Jahrling
Real-time bioimaging of infectious disease processes may aid countermeasure development and lead to an improved understanding of pathogenesis. However, few studies have identified biomarkers for monitoring infections using in vivo imaging. Previously, we demonstrated that positron emission tomography/computed tomography (PET/CT) imaging with [(18)F]-fluorodeoxyglucose (FDG) can monitor monkeypox disease progression in vivo in nonhuman primates (NHPs). In this study, we investigated [(18)F]-FDG-PET/CT imaging of immune processes in lymphoid tissues to identify patterns of inflammation in the monkepox NHP model and to determine the value of [(18)F]-FDG-PET/CT as a biomarker for disease and treatment outcomes...
August 16, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28814488/association-of-cardiovascular-disease-risk-factors-with-coronary-artery-calcium-volume-versus-density
#14
Isac C Thomas, Brandon Shiau, Julie O Denenberg, Robyn L McClelland, Philip Greenland, Ian H de Boer, Bryan R Kestenbaum, Gen-Min Lin, Michael Daniels, Nketi I Forbang, Dena E Rifkin, Jan Hughes-Austin, Matthew A Allison, J Jeffrey Carr, Joachim H Ix, Michael H Criqui
OBJECTIVES: Recently, the density score of coronary artery calcium (CAC) has been shown to be associated with a lower risk of cardiovascular disease (CVD) events at any level of CAC volume. Whether risk factors for CAC volume and CAC density are similar or distinct is unknown. We sought to evaluate the associations of CVD risk factors with CAC volume and CAC density scores. METHODS: Baseline measurements from 6814 participants free of clinical CVD were collected for the Multi-Ethnic Study of Atherosclerosis...
August 16, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28814307/which-intervention-is-better-for-malaria-vector-control-insecticide-mixture-long-lasting-insecticidal-nets-or-standard-pyrethroid-nets-combined-with-indoor-residual-spraying
#15
Corine Ngufor, Josias Fagbohoun, Jessica Critchley, Raphael N'Guessan, Damien Todjinou, David Malone, Martin Akogbeto, Mark Rowland
BACKGROUND: Malaria control today is threatened by widespread insecticide resistance in vector populations. The World Health Organization (WHO) recommends the use of a mixture of unrelated insecticides for indoor residual spraying (IRS) and long-lasting insecticidal nets (LNs) or as a combination of interventions for improved vector control and insecticide resistance management. Studies investigating the efficacy of these different strategies are necessary. METHODS: The efficacy of Interceptor(®) G2 LN, a newly developed LN treated with a mixture of chlorfenapyr (a pyrrole) and alpha-cypermethrin (a pyrethroid), was compared to a combined chlorfenapyr IRS and Interceptor(®) LN (a standard alpha-cypermethrin LN) intervention in experimental huts in Cove Southern Benin, against wild, free-flying, pyrethroid-resistant Anopheles gambiae s...
August 16, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28811968/il-32%C3%AE-induced-inflammation-constitutes-a-link-between-obesity-and-colon-cancer
#16
Victoria Catalán, Javier Gómez-Ambrosi, Amaia Rodríguez, Beatriz Ramírez, Victor A Ortega, José Luis Hernández-Lizoain, Jorge Baixauli, Sara Becerril, Fernando Rotellar, Víctor Valentí, Rafael Moncada, Camilo Silva, Javier Salvador, Gema Frühbeck
Growing evidence indicates that adipose tissue inflammation is an important mechanism whereby obesity promotes cancer risk and progression. Since IL-32 is an important inflammatory and remodeling factor in obesity and is also related to colon cancer (CC) development, the aim of this study was to explore whether IL-32 could function as an inflammatory factor in human obesity-associated CC promoting a microenvironment favorable for tumor growth. Samples obtained from 84 subjects [27 lean (LN) and 57 obese (OB)] were used in the study...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28811929/dual-energy-computed-tomography-angiography-virtual-calcified-plaque-subtraction-in-a-vascular-phantom
#17
Kwang Nam Jin, Jin Wook Chung, Eun-Ah Park, Whal Lee
BACKGROUND: Material decomposition of dual-energy computed tomography (DECT) enables subtraction of calcified plaque. PURPOSE: To evaluate the accuracy of lumen area measurement in calcified plaque by subtraction of DECT and to determine the effect of contrast material concentration, lumen diameter, density, and thickness of calcified plaque for the measurement. MATERIAL AND METHODS: Vessel phantoms were made with six lumen diameters (5.7, 4...
July 2017: Acta Radiologica Open
https://www.readbyqxmd.com/read/28810788/direct-measurement-of-site-specific-rates-of-reactions-of-h-with-c3h8-i-c4h10-and-n-c4h10
#18
Chia-Chieh Lin, Wei-Yu Chen, Hiroyuki Matsui, Niann-Shiah Wang
We measured the rates of abstraction of a hydrogen atom from specific sites in propane C3H8, 2-methyl propane (i-C4H10), and butane (n-C4H10); the sites are a primary hydrogen of C3H8 and i-C4H10 and a secondary hydrogen of n-C4H10. The excellent reproducibility of conditions of a diaphragm-less shock tube enabled us to conduct comparative measurements of the evolution of H atoms in three mixtures-(i) 0.5 ppm C2H5I + Ar, (ii) 0.5 ppm C2H5I + 50-100 ppm alkane as C3H8 or i-C4H10 or n-C4H10 + Ar, and (iii) the same concentrations of alkane + Ar without C2H5I-in the temperature range 1000-1200 K and at a pressure of 2...
August 14, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28807994/a-novel-computational-model-predicts-key-regulators-of-chemokine-gradient-formation-in-lymph-nodes-and-site-specific-roles-for-ccl19-and-ackr4
#19
Mohammad Jafarnejad, David C Zawieja, Bindi S Brook, Robert J B Nibbs, James E Moore
The chemokine receptor CCR7 drives leukocyte migration into and within lymph nodes (LNs). It is activated by chemokines CCL19 and CCL21, which are scavenged by the atypical chemokine receptor ACKR4. CCR7-dependent navigation is determined by the distribution of extracellular CCL19 and CCL21, which form concentration gradients at specific microanatomical locations. The mechanisms underpinning the establishment and regulation of these gradients are poorly understood. In this article, we have incorporated multiple biochemical processes describing the CCL19-CCL21-CCR7-ACKR4 network into our model of LN fluid flow to establish a computational model to investigate intranodal chemokine gradients...
August 14, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28807908/activity-of-the-%C3%AE-lactamase-inhibitor-ln-1-255-against-carbapenem-hydrolyzing-class-d-%C3%AE-lactamases-from-acinetobacter-baumannii
#20
Juan Carlos Vázquez-Ucha, María Maneiro, Marta Martínez-Guitián, John Buynak, Christopher R Bethel, Robert A Bonomo, Germán Bou, Margarita Poza, Concepción González-Bello, Alejandro Beceiro
The number of infections caused by Gram-negative pathogens carrying carbapenemases is increasing, and the group of carbapenem-hydrolyzing class D β-lactamases (CHDLs) is especially problematic. Several clinically important CHDLs have been identified in A. baumannii, including OXA-23, OXA-24/40, OXA-58, OXA-143, OXA-235, and the chromosomally encoded OXA-51. The selection and dissemination of carbapenem-resistant A. baumannii strains constitutes a serious global threat. Carbapenems have been successfully utilized as last resort antibiotics for the treatment of multi-drug-resistant A...
August 14, 2017: Antimicrobial Agents and Chemotherapy
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