Pengpeng Liu, Ping'an Ding, Jiaxuan Yang, Haotian Wu, Jiaxiang Wu, Honghai Guo, Peigang Yang, Yuan Tian, Lingjiao Meng, Qun Zhao
Accumulating evidence suggests that lymphangiogenesis plays a crucial role in lymphatic metastasis, leading to tumor immune tolerance. However, the specific mechanism remains unclear. In this study, miR-431-5p was markedly downregulated in both gastric cancer (GC) tissues and plasma exosomes, and its expression were correlated negatively with LN metastasis and poor prognosis. Mechanistically, miR-431-5p weakens the TGF-β1/SMAD2/3 signaling pathway by targeting ZEB1, thereby suppressing the secretion of VEGF-A and ANG2, which in turn hinders angiogenesis, lymphangiogenesis, and lymph node (LN) metastasis in GC...
April 24, 2024: Molecular Carcinogenesis