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Fuyou Liang, Xiaosheng Liu, Ryuhei Yamaguchi, Hao Liu
Recent studies raised increasing concern about the reliability of computer models in reproducing in vivo hemodynamics in cerebral aneurysms. Boundary condition problem is among the most frequently addressed issues since three-dimensional (3-D) modeling is usually restricted to local arterial segments. The present study focused on aneurysms on the anterior communicating artery (ACoA) which represent a large subgroup of detected cerebral aneurysms and, in particular, have a relatively high risk of rupture compared to aneurysms located in other regions...
October 6, 2016: Journal of Biomechanics
Lorenzo Rinaldo, Brandon A McCutcheon, Meghan E Murphy, Mohamad Bydon, Alejandro A Rabinstein, Giuseppe Lanzino
OBJECTIVE Hypoplasia of the A1 segment of the anterior cerebral artery is frequently observed in patients with anterior communicating artery (ACoA) aneurysms. The effect of this anatomical variant on ACoA aneurysm morphology is not well understood. METHODS Digital subtraction angiography images were reviewed for 204 patients presenting to the authors' institution with either a ruptured or an unruptured ACoA aneurysm. The ratio of the width of the larger A1 segment to the smaller A1 segment was calculated. Patients with an A1 ratio greater than 2 were categorized as having A1 segment hypoplasia...
September 30, 2016: Journal of Neurosurgery
Anthea H O'Neill, Ronil V Chandra, Leon T Lai
OBJECTIVE: Treatment outcomes for unruptured anterior communicating artery (ACoA) aneurysms are not well established. We aimed to investigate the safety and effectiveness of microsurgical clipping (MC), endovascular coiling (EC), and stent assisted coiling (SAC) of unruptured ACoA aneurysms to aid pretreatment clinical decisions. METHODS: A systematic review of the literature was conducted using the Ovid Medline and EMBASE electronic databases, encompassing all English language studies reporting treatment outcomes for unruptured ACoA aneurysms published between 2005 and 2015...
September 13, 2016: Journal of Neurointerventional Surgery
Metin Orakdöğen, Selin Tural Emon, Hakan Somay, Taner Engin, Merih Iş, Tayfun Hakan
AIM: Investigation of the vascular variations in patients with intracranial aneurysm in circle of Willis. MATERIAL AND METHODS: We used the data on 128 consecutive intracranial aneurysm cases. Cerebral angiography images were analyzed retrospectively. Arteries grouped as anterior cerebral arterial system (ACS), posterior cerebral arterial system (PCS) and middle cerebral arterial system (MCS) for grouping vascular variations. Lateralization, being single/multiple, gender; and also any connection with accompanying aneurysm's number, localization, dimension, being bleeding/incidental aneurysm has been inspected...
May 25, 2016: Turkish Neurosurgery
Jianfeng Liu, Jian Song, Di Zhao, Hui Li, Yingying Lu, Guobiao Wu, Kai Hou, Xuan Gao
BACKGROUND: Aneurysmal subarachnoid hemorrhage (aSAH) is a medical emergency with a high mortality and morbidity. There is a marked association of the ensuing neurological functional deficits following aSAH with the volume of hemorrhage. The volume of intracranial hemorrhage in aSAH is usually quantified by the revised Fisher grades. MATERIALS AND METHODS: A total of 155 patients who suffered from aSAH were evaluated for risk factors that led to an increased volume of intracranial hemorrhage...
July 2016: Neurology India
Shinichiro Teramoto, Helmut Bertalanffy
BACKGROUND: The anterior communicating artery (ACoA) often limits surgical exposure in the anterior interhemispheric approach. Although division of the ACoA has been proposed occasionally, it is rarely practiced, and criteria for such a surgical maneuver remain unknown. Our purpose was to identify key factors that allow for predicting the necessity of controlled ACoA division in the bifrontal basal interhemispheric approach. METHOD: Twenty-two consecutive patients who underwent surgery via the bifrontal basal interhemispheric approach for removal of various pathologic brain lesions were examined...
September 2016: Acta Neurochirurgica
Tara P McCoy, William L Dunlop
We investigated differences in the nature and implications of Adult Children of Alcoholics (ACOAs; n = 53) and non-ACOAs' (n = 80) narrative identities. Participants described six autobiographical narratives and completed measures of emotional functioning. Narratives were coded for redemptive (bad things turning good), contaminated (good things turning bad), and agentic (perceived control) imagery. ACOAs exhibited similar levels of redemptive and contaminated imagery, and lower levels of agency in their narratives, relative to non-ACOAs...
June 17, 2016: Memory
Romain Bourcier, Cédric Lenoble, Béatrice Guyomarch-Delasalle, Benjamin Daumas-Duport, Chrysanthi Papagiannaki, Richard Redon, Hubert Desal
OBJECTIVE The pathophysiological mechanisms responsible for the formation of intracranial aneurysms (IAs) remain only partially elucidated. However, current evidence suggests a genetic component. The purpose of this study was to investigate the specific anatomical variations in the arterial complex that are associated with the presence of anterior communicating artery (ACoA) aneurysms in the familial forms of IAs. METHODS This multicenter study investigated bifurcation IAs in patients who had a sporadic ACoA IA without a family history of IA (SACAA group), in patients who had an ACoA IA with a family history of IA (FACAA group), and in their healthy first-degree relatives (HFDRs)...
June 17, 2016: Journal of Neurosurgery
Felix Hendrik Pahl, Matheus Fernandes de Oliveira, André Luiz Beer-Furlan, José Marcus Rotta
BACKGROUND: Internal carotid artery bifurcation (ICAb) aneurysms account for about 2-15% of all intracranial aneurysms. In giant and complex cases, treatment may be difficult and dangerous, once some aneurysms have wide neck and anterior cerebral artery (ACA) and middle cerebral artery (MCA) may arise from the aneurysm itself. Clip reconstruction may be difficult in such cases. Whenever possible, the occlusion of ACA transform the bifurcation in a single artery reconstruction (ICA to MCA), much easier than a bifurcation reconstruction...
2016: Surgical Neurology International
Shahira M Ezzat, Menna El Gaafary, Abeer M El Sayed, Omar M Sabry, Zeinab Y Ali, Susanne Hafner, Michael Schmiech, Lu Jin, Tatiana Syrovets, Thomas Simmet
The current study aimed to investigate the protective effect of the cardenolide glycoside acovenoside A (AcoA) against doxorubicin-induced cardiotoxicity in mice. AcoA was isolated from the pericarps of Acokanthera oppositifolia to chemical homogeneity and characterized by means of one- and two-dimensional nuclear magnetic resonance spectroscopy. AcoA exhibited relatively low toxicity in mice (LD50 = 223.3 mg/kg bw). Repeated administration of doxorubicin induced cardiotoxicity manifested by reduced activity of myocardial membrane-bound ion pumps and elevated serum biomarkers of myocardial dysfunction, oxidative stress, and inflammation...
August 2016: Journal of Pharmacology and Experimental Therapeutics
Lianghao Fan, Boli Lin, Ting Xu, Nengzhi Xia, Xiaotong Shao, Xianxi Tan, Ming Zhong, Yunjun Yang, Bing Zhao
BACKGROUND: Intraprocedural rupture and thrombus formation are serious complications during coiling of ruptured intracranial aneurysms, and they more often occur in patients with anterior communicating artery (ACoA) aneurysms. OBJECTIVE: To identify independent predictors of intraprocedural rupture and thrombus formation during coiling of ruptured ACoA aneurysms. METHODS: Between January 2008 and February 2015, 254 consecutive patients with 255 ACoA aneurysms were treated with coiling...
April 5, 2016: Journal of Neurointerventional Surgery
Jing Fu, Guangxin Huo, Lili Feng, Yufeng Mao, Zhiwen Wang, Hongwu Ma, Tao Chen, Xueming Zhao
BACKGROUND: 2,3-Butanediol (2,3-BD) with low toxicity to microbes, could be a promising alternative for biofuel production. However, most of the 2,3-BD producers are opportunistic pathogens that are not suitable for industrial-scale fermentation. In our previous study, wild-type Bacillus subtilis 168, as a class I microorganism, was first found to generate only d-(-)-2,3-BD (purity >99 %) under low oxygen conditions. RESULTS: In this work, B. subtilis was engineered to produce chiral pure meso-2,3-BD...
2016: Biotechnology for Biofuels
Boli Lin, Weijian Chen, Lei Ruan, Yongchun Chen, Ming Zhong, Qichuan Zhuge, Liang Hao Fan, Bing Zhao, Yunjun Yang
OBJECTIVES: Ruptured anterior communicating artery (ACoA) aneurysms occur more frequently in men. The purpose of the study was to investigate sex difference in aneurysm morphologies and clinical outcomes in patients with ruptured ACoA aneurysms. SETTING: A tertiary referral hospital. PARTICIPANTS: A total of 574 consecutive patients with ACoA aneurysms were admitted to our hospital from December 2007 to February 2015. In all, 474 patients (257 men and 217 women) with ruptured ACoA aneurysms were included in the study...
2016: BMJ Open
Lianghao Fan, Xianxi Tan, Ye Xiong, Kuang Zheng, Zequn Li, Dajun Liu, Ming Zhong, Bing Zhao
OBJECTIVE: Endovascular coiling of anterior communicating artery (ACoA) aneurysms has evolved; however, stent-assisted coiling of ruptured aneurysms remains controversial. We aimed to compare periprocedural complications, angiographic and clinical outcomes after stent-assisted coiling with coiling alone of ruptured ACoA aneurysms. METHODS: We performed a retrospective review of consecutive 222 patients with ruptured ACoA aneurysms treated with endovascular coiling within 7 days after ictus...
May 2016: Clinical Neurology and Neurosurgery
Ting Xu, Boli Lin, Shuailiang Liu, Xiaotong Shao, Nengzhi Xia, Yue Zhang, Haoli Xu, Yunjun Yang, Ming Zhong, Qichuan Zhuge, Bing Zhao, Weijian Chen
BACKGROUND: Anterior communicating artery (AcoA) aneurysms have a high rupture risk, and ruptured AcoA aneurysms tend to be smaller than other intracranial aneurysms. We aimed to determine the incidence and morphologic predictors of aneurysm rupture of very small AcoA aneurysms. METHODS: We conducted a retrospective analysis of 519 consecutive patients with single AcoA aneurysms between December 2007 and February 2015 in our hospital. Aneurysm morphologies were re-measured using CT angiography images...
March 23, 2016: Journal of Neurointerventional Surgery
Sanghyeon Kim, Myongjin Kang, Jae-Hyung Choi, Dong Won Kim
Many studies lay emphasis on the clinical importance of perforating branches of the anterior communicating artery (ACoA) and report that vascular damage of the perforators from ACoA aneurysm during surgery cause subsequent postoperative amnesia. The purpose of our study was to analyze the safety of parent artery occlusion for ACoA aneurysm coiling based on the anatomical features of the ACoA complex in 13 patients with 13 ACoA aneurysms. All patients underwent coiling of the aneurysm sac and ACoA. Aneurysm characteristics including size, dome-to-neck ratio, anterior/posterior orientation of the aneurysm dome with respect to the axis of the pericallosal artery, location of the aneurysm neck with respect to the A1-A2 segment of the anterior cerebral artery (ACA) or the ACoA, and the presence of hypoplasia/aplasia of A1 segment were assessed...
June 2016: Neuroradiology Journal
Xuhua Tan, Haotian Lin, Zhuoling Lin, Jingjing Chen, Xiangchen Tang, Lixia Luo, Weirong Chen, Yizhi Liu
The objective of this study was to investigate capsular outcomes 12 months after pediatric cataract surgery without intraocular lens implantation via qualitative classification and quantitative measurement.This study is a cross-sectional study that was approved by the institutional review board of Zhongshan Ophthalmic Center of Sun Yat-sen University in Guangzhou, China.Digital coaxial retro-illumination photographs of 329 aphakic pediatric eyes were obtained 12 months after pediatric cataract surgery without intraocular lens implantation...
March 2016: Medicine (Baltimore)
Xiaotong Shao, Hao Wang, Yan Wang, Ting Xu, Yingbao Huang, Jincheng Wang, Weijian Chen, Yunjun Yang, Bing Zhao
OBJECTIVE: Recent studies have shown that anterior projection aneurysms are associated with increased risk of rupture of anterior communicating artery (ACoA) aneurysms. We aimed to determine differences in patient characteristics and aneurysm morphologies between the anterior projection and posterior projection aneurysm groups and to determine morphological predictors of rupture of the anterior projection aneurysms. MATERIALS AND METHODS: December 2007 to February 2015, 503 consecutive patients with single ACoA aneurysms were included in this report...
April 2016: Clinical Neurology and Neurosurgery
Akira Uchino, Naoko Saito, Takahiro Uehara, Hiroaki Neki, Sinya Kohyama, Fumitaka Yamane
Variations of the anterior cerebral artery-anterior communicating artery (ACoA) complex are common. Most are duplicated or partially duplicated ACoAs that are confused with fenestration of the ACoA. We report here an extremely rare case of true fenestration of the ACoA diagnosed by magnetic resonance angiography. Tiny true fenestrations of the ACoA may be overlooked easily by MR angiography. Partial maximum-intensity-projection image and volume-rendering image are useful in identifying true fenestration of the ACoA...
February 17, 2016: Surgical and Radiologic Anatomy: SRA
Agustina Creus, María R Ferreira, María E Oliva, Yolanda B Lombardo
This study explores the mechanisms underlying the altered lipid metabolism in the heart of dyslipemic insulin-resistant (IR) rats fed a sucrose-rich diet (SRD) and investigates if chia seeds (rich in α-linolenic acid 18:3, n-3 ALA) improve/reverse cardiac lipotoxicity. Wistar rats received an SRD-diet for three months. Half of the animals continued with the SRD up to month 6. The other half was fed an SRD in which the fat source, corn oil (CO), was replaced by chia seeds from month 3 to 6 (SRD+chia). A reference group consumed a control diet (CD) all the time...
2016: Journal of Clinical Medicine
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