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Adult Children of Alcoholics

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https://www.readbyqxmd.com/read/28426902/hepatic-steatosis-after-pediatric-liver-transplant
#1
Emily R Perito, Tabitha Vase, Rageshree Ramachandran, Andrew Phelps, Kuang-Yu Jen, Robert H Lustig, Vickie A Feldstein, Philip Rosenthal
RATIONALE: Hepatic steatosis develops after liver transplant in 30% of adults, and non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in non-transplanted children. However, post-transplant steatosis has been minimally studied in pediatric liver transplant recipients. We explored the prevalence, persistence, and association with chronic liver damage of hepatic steatosis in these children. RESULTS: In this single-center study of pediatric patients transplanted 1988-2015 (n=318), 31% of those with any post-transplant biopsy (n=271) had ≥1 biopsy with steatosis...
April 20, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28411894/the-effects-of-dietary-factors-on-blood-pressure
#2
REVIEW
Lawrence J Appel
Evidence supports that multiple dietary factors affect blood pressure (BP). Dietary changes that effectively lower BP are weight loss, reduced sodium intake, increased potassium intake, moderation of alcohol intake, and Dietary Approaches to Stop Hypertension-style and vegetarian dietary patterns. In view of the increasing levels of BP in children and adults and the continuing epidemic of BP-related cardiovascular and renal diseases, efforts to reduce BP in both nonhypertensive and hypertensive individuals are warranted...
May 2017: Cardiology Clinics
https://www.readbyqxmd.com/read/28407146/high-rates-of-latent-tb-infection-in-contacts-and-the-wider-community-in-south-india
#3
Padmanesan Narasimhan, Chandini Raina MacIntyre, Dilip Mathai, James Wood
Background: We aimed to compare TB transmission rates between case and community households in Vellore, South India. Methods: 359 household contacts (HHC) and 363 community contacts (CC) were assessed with tuberculin skin test (TST) and QuantiFERON TB Gold In-Tube test (QFT) between August 2010 and September 2011. Concordance test and multivariate risk factor assessment were conducted using logistic regression adjusted for clustering. Results: Latent TB infection (LTBI) positivity was similar between the two groups using both tests, with only moderate concordance observed between QFT and TST...
April 12, 2017: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28403466/the-role-of-maternal-adverse-childhood-experiences-and-race-in-intergenerational-high-risk-smoking-behaviors
#4
Veronica A Pear, Lucia C Petito, Barbara Abrams
Introduction: A history of adversity in childhood is associated with cigarette smoking in adulthood, but there is less evidence for prenatal and next-generation offspring smoking. We investigated the association between maternal history of childhood adversity, pregnancy smoking, and early initiation of smoking in offspring, overall and by maternal race/ethnicity. Methods: Data on maternal childhood exposure to physical abuse, household alcohol abuse, and household mental illness, prenatal smoking behaviors, and offspring age of smoking initiation were analyzed from the US National Longitudinal Survey of Youth 1979 (NLSY79, n = 2999 mothers) and the NLSY79 Children and Young Adults Survey (NLSYCYA, n = 6596 children)...
May 1, 2017: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/28397375/elevation-of-circulating-microrna-levels-in-obese-children-compared-to-healthy-controls
#5
M D Thompson, M J Cismowski, M Serpico, A Pusateri, D R Brigstock
As childhood obesity increases, it is becoming important to understand the complications of obesity in children and develop novel biomarkers. Evidence indicates that microRNAs (miRNA) are dys-regulated in obesity and may serve as sensitive and specific circulating biomarkers. Non-alcoholic fatty liver disease (NAFLD) is a complication of obesity that ultimately requires a liver biopsy to determine disease severity. While studies have been conducted in adults, no study to date has examined circulating miRNAs in children with obesity and NAFLD...
April 10, 2017: Clinical Obesity
https://www.readbyqxmd.com/read/28393325/parent-offspring-transmission-of-internalizing-and-sensory-over-responsivity-symptoms-in-adolescence
#6
Carol A Van Hulle, Kathryn Lemery-Chalfant, H Hill Goldsmith
Reactions to sensory experiences are an overlooked correlate of affective regulation, despite the importance of bodily states on psychological processes. Children who display sensory over-responsivity (i.e., adverse reactions to typical sensations) are at greater risk for developing affective disorders. We extended this literature to adolescents and their middle-aged parents. Participants in a birth record-based study of families of adolescent twins (N = 506 families; 1012 adolescents; 53% female) completed a subset of items from the Adult Sensory Profile...
April 10, 2017: Journal of Abnormal Child Psychology
https://www.readbyqxmd.com/read/28391109/attention-deficit-hyperactivity-disorder-and-substance-abuse-an-investigation-in-young-austrian-males
#7
Anita Riegler, Sabine Völkl-Kernstock, Otto Lesch, Henriette Walter, Katrin Skala
BACKGROUND: Many studies have found an association between Substance Use Disorders (SUDs) and Attention Deficit Hyperactivity Disorder (ADHD) in children, adolescents and adults. We intended to determine whether substance abuse and SUDs are associated with former and current ADHD symptomatology in a non-clinical sample of 17 and 18 year old males. METHOD: A representative sample of 3280 young men (6.8% of all males born in Austria in the respective year) was investigated during the examination for military service...
April 4, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28385059/maternal-alcohol-and-tobacco-consumption-and-the-association-with-their-9-to-14-year-old-children-s-body-mass-index
#8
Rejane Augusta de Oliveira Figueiredo, Eva Roos, Johan G Eriksson, Sabina Simola-Ström, Elisabete Weiderpass
AIMS: Little is known about impact of maternal alcohol and tobacco consumption on adolescents' body size. The purpose of this study was to evaluate whether maternal alcohol or tobacco consumption is associated with their children's body size in adolescence, assessed by Body Mass Index (BMI). METHODS: This study was conduct in subjects recruited into the Finnish Health in Teens cohort (Fin-HIT) between 2011 and 2014. A total of 4525 subjects aged between 9 and 14 years and their mothers or female adults responsible for the children were analysed...
April 1, 2017: Scandinavian Journal of Public Health
https://www.readbyqxmd.com/read/28383757/prenatal-and-adult-androgen-activities-in-alcohol-dependence
#9
B Lenz, C Mühle, B Braun, C Weinland, P Bouna-Pyrrou, J Behrens, S Kubis, K Mikolaiczik, M-R Muschler, S Saigali, M Sibach, P Tanovska, S E Huber, U Hoppe, A Eichler, H Heinrich, G H Moll, A Engel, T W Goecke, M W Beckmann, P A Fasching, C P Müller, J Kornhuber
OBJECTIVE: Alcohol dependence is more prevalent in men than in women. The evidence for how prenatal and adult androgens influence alcohol dependence is limited. We investigated the effects of prenatal and adult androgen activity on alcohol dependence. Moreover, we studied how the behaviours of pregnant women affect their children's prenatal androgen load. METHOD: We quantified prenatal androgen markers (e.g., second-to-fourth finger length ratio [2D : 4D]) and blood androgens in 200 early-abstinent alcohol-dependent in-patients and 240 controls (2013-2015, including a 12-month follow-up)...
April 6, 2017: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/28376457/updated-priorities-among-effective-clinical-preventive-services
#10
Michael V Maciosek, Amy B LaFrance, Steven P Dehmer, Dana A McGree, Thomas J Flottemesch, Zack Xu, Leif I Solberg
PURPOSE: The Patient Protection and Affordable Care Act's provisions for first-dollar coverage of evidence-based preventive services have reduced an important barrier to receipt of preventive care. Safety-net providers, however, still serve a substantial uninsured population, and clinician and patient time remain limited in all primary care settings. As a consequence, decision makers continue to set priorities to help focus their efforts. This report updates estimates of relative health impact and cost-effectiveness for evidence-based preventive services...
January 2017: Annals of Family Medicine
https://www.readbyqxmd.com/read/28366413/adverse-effects-of-female-obesity-and-interaction-with-race-on-reproductive-potential
#11
REVIEW
Barbara Luke
Across the reproductive spectrum, obesity is associated with greater risks for adverse health outcomes, including higher rates of infertility, subfertility, early pregnancy loss, fetal deaths and stillbirths, congenital anomalies, and pregnancy complications. The excess reproductive morbidity associated with obesity may increase with longer duration, making the current trends among children and young adults particularly critical in terms of their future reproductive potential. Obese women have a lower chance of pregnancy following in vitro fertilization (IVF), require higher dosages of gonadotropins, and have reduced rates of implantation, clinical intrauterine gestation, and live birth rates and increased rates of pregnancy loss, as well as greater risks for prematurity and preeclampsia even when stratified by plurality...
April 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28355042/contributing-factors-and-mental-health-outcomes-of-first-suicide-attempt-during-childhood-and-adolescence-results-from-a-nationally-representative-study
#12
Hugo Peyre, Nicolas Hoertel, Coline Stordeur, Gaële Lebeau, Carlos Blanco, Kibby McMahon, Romain Basmaci, Cédric Lemogne, Frédéric Limosin, Richard Delorme
OBJECTIVE: To investigate whether risk factors for suicide attempts differ in children and adolescents and to categorize adulthood mental health outcomes of child and adolescent suicide attempters in the general population. METHODS: Using a large (N = 34,653), nationally representative US adult sample, the 2004-2005 National Epidemiologic Survey on Alcohol and Related Conditions, we examined whether individuals who first attempted suicide during childhood (under the age of 13 years) differ from those who first attempted suicide during adolescence (13 through 17 years) in (1) contributing factors for first suicide attempt, including mental disorders and traumatic experiences that occurred before the first suicide attempt, parental history of mental disorders, and family poverty and (2) adulthood mental health outcomes, including lifetime and current prevalence of DSM-IV psychiatric disorders and quality of life measures...
March 28, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28340189/the-relationship-between-pain-severity-and-alcohol-use-among-school-aged-children-and-adolescents-the-moderating-role-of-drinking-motives
#13
Claudia Horn-Hofmann, Zina Trost, Anne Hublet, Sylvie Mrug, Joris Van Damme, Tine Vervoort
Objective. : Evidence from adult samples suggests a co-occurrence between pain and alcohol abuse. However, studies in adolescents are scarce and results are inconsistent, with some studies observing heightened and others observing reduced alcohol consumption in adolescents suffering from pain. We hypothesized that in adolescents the association between pain and alcohol use will be moderated by drinking motives. Methods. : Data from a large representative sample of Flemish school children and adolescents (N = 10,650, 50...
March 15, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28335746/does-continuous-trusted-adult-support-in-childhood-impart-life-course-resilience-against-adverse-childhood-experiences-a-retrospective-study-on-adult-health-harming-behaviours-and-mental-well-being
#14
Mark A Bellis, Katie Hardcastle, Kat Ford, Karen Hughes, Kathryn Ashton, Zara Quigg, Nadia Butler
BACKGROUND: Adverse childhood experiences (ACEs) including child abuse and household problems (e.g. domestic violence) increase risks of poor health and mental well-being in adulthood. Factors such as having access to a trusted adult as a child may impart resilience against developing such negative outcomes. How much childhood adversity is mitigated by such resilience is poorly quantified. Here we test if access to a trusted adult in childhood is associated with reduced impacts of ACEs on adoption of health-harming behaviours and lower mental well-being in adults...
March 23, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28324675/arterial-stiffness-in-hiv-infected-youth-and-associations-with-hiv-related-variables
#15
Allison Ross Eckard, Paolo Raggi, Joshua H Ruff, Mary Ann O'Riordan, Julia C Rosebush, Danielle Labbato, Julie E Daniels, Monika Uribe-Leitz, Christopher T Longenecker, Grace A McComsey
Children and young adults infected with HIV are at elevated risk for cardiovascular disease (CVD). However, scarce data exist on the utility of non-invasive methods to diagnose subclinical CVD, such as pulse wave velocity (PWV), a non-invasive measure of arterial stiffness. The objectives of this study were to assess the relationship of carotid-femoral PWV with subclinical atherosclerosis measured by carotid intima-media thickness (IMT), compare measurements to healthy controls, and evaluate variables associated with PWV in HIV-infected youth...
March 21, 2017: Virulence
https://www.readbyqxmd.com/read/28324110/effects-of-metreleptin-in-pediatric-patients-with-lipodystrophy
#16
Rebecca J Brown, Cristina Adelia Meehan, Elaine Cochran, Kristina I Rother, David E Kleiner, Mary Walter, Phillip Gorden
Context: Lipodystrophy syndromes are rare disorders of deficient adipose tissue. Metreleptin, a human analog of leptin, improved metabolic abnormalities in mixed cohorts of leptin-deficient children and adults with lipodystrophy. Objective: Determine effects of metreleptin on diabetes, hyperlipidemia, non-alcoholic fatty liver disease (NAFLD), growth, and puberty in leptin-deficient pediatric patients with lipodystrophy. Design: Prospective, single-arm, open-label studies with continuous enrollment since 2000...
January 23, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28319814/time-specific-and-cumulative-effects-of-exposure-to-parental-externalizing-behavior-on-risk-for-young-adult-alcohol-use-disorder
#17
Alexis C Edwards, Sara L Lönn, Katherine J Karriker-Jaffe, Jan Sundquist, Kenneth S Kendler, Kristina Sundquist
BACKGROUND: Previous studies indicate that parental externalizing behavior (EB) is a robust risk factor for alcohol use disorder (AUD) in their children, and that this is due to both inherited genetic liability and environmental exposure. However, it remains unclear whether the effects of exposure to parental EB vary as a function of timing and/or chronicity. METHODS: We identified biological parents with an alcohol use disorder, drug abuse, or criminal behavior, during different periods of their child's upbringing, using Swedish national registries...
March 8, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/28319602/low-hepatic-tissue-copper-in-pediatric-non-alcoholic-fatty-liver-disease
#18
Michael Mendoza, Shelley Caltharp, Ming Song, Lindsay Collin, Juna V Konomi, Craig J McClain, Miriam B Vos
OBJECTIVE: Animal models and studies in adults have demonstrated that copper restriction increases severity of liver injury in non-alcoholic fatty liver disease (NAFLD). This has not been studied in children. We aimed to determine if lower tissue copper is associated with increased NAFLD severity in children. METHODS: This was a retrospective study of pediatric patients who had a liver biopsy including a hepatic copper quantitation. The primary outcome compared hepatic copper concentration in NAFLD versus non-NAFLD...
March 17, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28318463/decreasing-the-overall-environmental-impact-of-the-dutch-diet-how-to-find-healthy-and-sustainable-diets-with-limited-changes
#19
Gerard Fh Kramer, Marcelo Tyszler, Pieter Van't Veer, Hans Blonk
OBJECTIVE: To find diets optimised on nutrition and environmental impact close to the current Dutch diet and to identify the most effective and acceptable options for mitigating environmental impact. DESIGN: Linear programming was used to optimise diets of Dutch men and women aged 9-69 years, divided into ten age-gender groups. The analysis included nutrient composition, a metric for popularity and life cycle assessments of 207 food products. Greenhouse gas emissions, fossil energy use and land occupation were used to calculate a weighted score for the overall environmental impact...
March 20, 2017: Public Health Nutrition
https://www.readbyqxmd.com/read/28268031/-content-analysis-of-food-adverts-aimed-at-children
#20
José Antonio Ponce-Blandón, Manuel Pabón-Carrasco, María de Las Mercedes Lomas-Campos
OBJECTIVE: To determine the contents and persuasive techniques used in processed food adverts aimed at children in Andalusia, comparing them with those aimed at adults. METHODS: Study based on advert content analysis with two phases: a descriptive design phase and an analytical observational design phase. A sample of adverts from 60hours of broadcasting from the two most watched television channels in Andalusia. RESULTS: A total of 416 food and non-alcoholic beverage adverts were obtained, for 91 different products...
May 2017: Gaceta Sanitaria
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