Ravi Holani, Paula T Littlejohn, Karlie Edwards, Charisse Petersen, Kyung-Mee Moon, Richard G Stacey, Tahereh Bozorgmehr, Zachary J Gerbec, Antonio Serapio-Palacios, Zakhar Krekhno, Katherine Donald, Leonard J Foster, Stuart E Turvey, B Brett Finlay
BACKGROUND & AIMS: Micronutrient deficiency (MND i.e., lack of vitamins and minerals) during pregnancy is a major public health concern. Historically, studies have considered micronutrients in isolation; however, MNDs rarely occur alone. The impact of co-occurring MNDs on public health, mainly in shaping mucosal colonization by pathobionts from Enterobacteriaceae family, remains undetermined due to lack of relevant animal models. METHODS: To establish a maternal murine model of multiple MND (MMND), we customized a diet deficient in vitamins (A, B12 and B9) and minerals (iron and zinc) that most commonly affect children and women of reproductive age...
January 31, 2024: Cellular and Molecular Gastroenterology and Hepatology