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https://www.readbyqxmd.com/read/29778263/hepatitis-c-virus-elimination-in-the-human-immunodeficiency-virus-coinfected-population-leveraging-the-existing-human-immunodeficiency-virus-infrastructure
#1
REVIEW
Meredith E Clement, Lauren F Collins, Julius M Wilder, Michael Mugavero, Taryn Barker, Susanna Naggie
The objective of this review is to consider how existing human immunodeficiency virus (HIV) infrastructure may be leveraged to inform and improve hepatitis C virus (HCV) treatment efforts in the HIV-HCV coinfected population. Current gaps in HCV care relevant to the care continuum are reviewed. Successes in HIV treatment are then applied to the HCV treatment model for coinfected patients. Finally, the authors give examples of HCV treatment strategies for coinfected patients in both domestic and international settings...
June 2018: Infectious Disease Clinics of North America
https://www.readbyqxmd.com/read/29777614/enhancing-the-detection-of-injuries-and-near-misses-among-patient-care-staff-in-a-large-pediatric-hospital
#2
Maurizio Macaluso, Lauren A Summerville, Meredith E Tabangin, Nancy M Daraiseh
Objectives Compared to other industries, healthcare has one of the highest rates of non-fatal occupational injury/illness. Evidence indicates these rates are underestimated, highlighting the need for improved injury surveillance. This study aims to demonstrate the feasibility of integrating active data collection in a passive injury surveillance system to improve detection of injuries in a healthcare establishment. Methods Using digital voice recorders (DVR), pediatric healthcare providers prospectively recorded events throughout their shift for two weeks...
May 7, 2018: Scandinavian Journal of Work, Environment & Health
https://www.readbyqxmd.com/read/29776727/promise-and-challenges-of-using-combined-moderator-methods-to-personalize-mental-health-treatment
#3
EDITORIAL
Meredith L Wallace, Stephen F Smagula
No abstract text is available yet for this article.
April 24, 2018: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/29772684/the-changing-landscape-in-the-genetic-etiology-of-human-tooth-agenesis
#4
REVIEW
Meredith A Williams, Ariadne Letra
Despite much progress in understanding the genetics of syndromic tooth agenesis (TA), the causes of the most common, isolated TA remain elusive. Recent studies have identified novel genes and variants contributing to the etiology of TA, and revealed new pathways in which tooth development genes belong. Further, the use of new research approaches including next-generation sequencing has provided increased evidence supporting an oligogenic inheritance model for TA, and may explain the phenotypic variability of the condition...
May 16, 2018: Genes
https://www.readbyqxmd.com/read/29771361/factor-structure-of-a-spanish-translation-of-an-obesity-specific-parent-report-measure-of-health-related-quality-of-life
#5
Kelsey B Borner, Tarrah B Mitchell, Jane S Gray, Ann M Davis, Stephen J Pont, Brooke R Sweeney, Sarah Hampl, Meredith L Dreyer Gillette
Objective: Latino youth are disproportionately affected by pediatric obesity and consequently experience impaired health-related quality of life (HRQOL). Although many caregivers of Latino youth do not speak English fluently, no validated Spanish translations of obesity-specific HRQOL measures exist for this population. Therefore, non-English-speaking Latino parents have typically been excluded from analyses related to HRQOL. This study assesses the factor structure of a Spanish translation of a parent-report measure of obesity-specific HRQOL, Sizing Them Up, in a treatment-seeking sample of children with obesity...
May 15, 2018: Journal of Pediatric Psychology
https://www.readbyqxmd.com/read/29770376/field-studies-reveal-functions-of-chemical-mediators-in-plant-interactions
#6
REVIEW
Meredith C Schuman, Ian T Baldwin
Plants are at the trophic base of most ecosystems, embedded in a rich network of ecological interactions in which they evolved. While their limited range and speed of motion precludes animal-typical behavior, plants are accomplished chemists, producing thousands of specialized metabolites which may function to convey information, or even to manipulate the physiology of other organisms. Plants' complex interactions and their underlying mechanisms are typically dissected within the controlled environments of growth chambers and glasshouses, but doing so introduces conditions alien to plants evolved in natural environments, such as being pot-bound, and receiving artificial light with a spectrum very different from sunlight...
May 17, 2018: Chemical Society Reviews
https://www.readbyqxmd.com/read/29767637/hiv-risk-among-adolescent-girls-and-young-women-in-age-disparate-partnerships-evidence-from-kwazulu-natal-south-africa
#7
Brendan Maughan-Brown, Gavin George, Sean Beckett, Meredith Evans, Lara Lewis, Cherie Cawood, David Khanyile, Ayesha B M Kharsany
BACKGROUND: Evidence on the role of age-disparate partnerships in high HIV-infection rates among young women in sub-Saharan Africa remains inconclusive. This study examined the HIV-infection risk associated with age-disparate partnerships among 15- to 24-year-old women in a hyperendemic setting in South Africa. METHODS: Face-to-face questionnaire, and laboratory HIV and viral load data were collected during 2014-2015 among a representative sample (15-49 years old) in KwaZulu-Natal...
June 1, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29767462/soluble-fiber-use-in-pediatric-short-bowel-syndrome-a-survey-on-prevailing-practices
#8
Meredith Linley Harvie, Margaret Alyssa Tucker Norris, Wednesday Marie A Sevilla
BACKGROUND: In pediatric short bowel syndrome (SBS), adding fiber to enteral feedings is 1 treatment method to manage increased stool output. However, there are no standardized recommendations on the use of fiber in this setting, including type, dosage, titration strategies, etc. OBJECTIVE: The aim of this study is to determine current prevailing practices on the use of fiber in the treatment of chronic high stool output in the pediatric SBS population. METHODS: An anonymous electronic survey with 13 questions was sent through health professional electronic mailing lists...
May 16, 2018: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/29765151/apatorsen-plus-docetaxel-versus-docetaxel-alone-in-platinum-resistant-metastatic-urothelial-carcinoma-borealis-2
#9
Jonathan E Rosenberg, Noah M Hahn, Meredith M Regan, Lillian Werner, Ajjai Alva, Saby George, Joel Picus, Robert Alter, Arjun Balar, Jean Hoffman-Censits, Petros Grivas, Richard Lauer, Elizabeth A Guancial, Christopher Hoimes, Guru Sonpavde, Constantine Albany, Mark N Stein, Tim Breen, Cindy Jacobs, Kirsten Anderson, Joaquim Bellmunt, Aly-Khan A Lalani, Sumanta Pal, Toni K Choueiri
BACKGROUND: A randomised study to assess the addition of apatorsen, an antisense oligonucleotide that inhibits Hsp27 expression, to docetaxel in patients with metastatic urothelial carcinoma (mUC) relapsed after prior platinum-based chemotherapy. METHODS: Multicentre, phase II study with 1:1 randomisation to apatorsen (three loading doses at 600 mg intravenous followed by weekly doses) plus docetaxel (75 mg/m2 intravenous every 21 days) (A/D) or docetaxel alone...
May 16, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29763378/characterization-of-thermally-activated-metalloenediyne-cytotoxicity-in-human-melanoma-cells
#10
Eric J Keller, Meghan Porter, Joy E Garrett, Meredith Varie, Haiyan Wang, Karen E Pollok, John J Turchi, Jeffrey M Zaleski, Joseph R Dynlacht
Enediynes are a highly cytotoxic class of compounds. However, metallation of these compounds may modulate their activation, and thus their cytotoxicity. We previously demonstrated that cytotoxicity of two different metalloenediynes, including (Z)-N,N'-bis[1-pyridyl-2-yl-meth-(E)-ylidene]octa-4-ene-2,6-diyne-1,8-diamine] (PyED), is potentiated when the compounds are administered to HeLa cells during hyperthermia treatment at concentrations that are minimally or not cytotoxic at 37°C. In this study, we further characterized the concentration, time and temperature dependence of cytotoxicity of PyED on human U-1 melanoma cells...
May 15, 2018: Radiation Research
https://www.readbyqxmd.com/read/29760388/cell-of-origin-and-mutation-pattern-define-three-clinically-distinct-classes-of-sebaceous-carcinoma
#11
Jeffrey P North, Justin Golovato, Charles J Vaske, J Zachary Sanborn, Andrew Nguyen, Wei Wu, Benjamin Goode, Meredith Stevers, Kevin McMullen, Bethany E Perez White, Eric A Collisson, Michele Bloomer, David A Solomon, Stephen C Benz, Raymond J Cho
Sebaceous carcinomas (SeC) are cutaneous malignancies that, in rare cases, metastasize and prove fatal. Here we report whole-exome sequencing on 32 SeC, revealing distinct mutational classes that explain both cancer ontogeny and clinical course. A UV-damage signature predominates in 10/32 samples, while nine show microsatellite instability (MSI) profiles. UV-damage SeC exhibited poorly differentiated, infiltrative histopathology compared to MSI signature SeC (p = 0.003), features previously associated with dissemination...
May 14, 2018: Nature Communications
https://www.readbyqxmd.com/read/29760121/the-marine-system-of-the-west-antarctic-peninsula-status-and-strategy-for-progress
#12
Katharine R Hendry, Michael P Meredith, Hugh W Ducklow
No abstract text is available yet for this article.
June 28, 2018: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/29760117/inter-decadal-variability-of-phytoplankton-biomass-along-the-coastal-west-antarctic-peninsula
#13
Hyewon Kim, Hugh W Ducklow, Doris Abele, Eduardo M Ruiz Barlett, Anita G J Buma, Michael P Meredith, Patrick D Rozema, Oscar M Schofield, Hugh J Venables, Irene R Schloss
The West Antarctic Peninsula (WAP) is a climatically sensitive region where periods of strong warming have caused significant changes in the marine ecosystem and food-web processes. Tight coupling between phytoplankton and higher trophic levels implies that the coastal WAP is a bottom-up controlled system, where changes in phytoplankton dynamics may largely impact other food-web components. Here, we analysed the inter-decadal time series of year-round chlorophyll- a (Chl) collected from three stations along the coastal WAP: Carlini Station at Potter Cove (PC) on King George Island, Palmer Station on Anvers Island and Rothera Station on Adelaide Island...
June 28, 2018: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/29760115/evidences-of-strong-sources-of-dfe-and-dmn-in-ryder-bay-western-antarctic-peninsula
#14
Johann Bown, Hans van Haren, Michael P Meredith, Hugh J Venables, Patrick Laan, J Alexander Brearley, Hein J W de Baar
The spatial distribution, biogeochemical cycling and external sources of dissolved iron and dissolved manganese (DFe and DMn) were investigated in Ryder Bay, a small coastal embayment of the West Antarctic Peninsula, during Austral summer (2013 and 2014). Dissolved concentrations were measured throughout the water column at 11 stations within Ryder Bay. The concentration ranges of DFe and DMn were large, between 0.58 and 32.7 nM, and between 0.18 and 26.2 nM, respectively, exhibiting strong gradients from the surface to the bottom...
June 28, 2018: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/29760114/a-shallow-bathtub-ring-of-local-sedimentary-iron-input-maintains-the-palmer-deep-biological-hotspot-on-the-west-antarctic-peninsula-shelf
#15
Robert M Sherrell, Amber L Annett, Jessica N Fitzsimmons, Vincent J Roccanova, Michael P Meredith
Palmer Deep (PD) is one of several regional hotspots of biological productivity along the inner shelf of the West Antarctic Peninsula. The proximity of hotspots to shelf-crossing deep troughs has led to the 'canyon hypothesis', which proposes that circumpolar deep water flowing shoreward along the canyons is upwelled on the inner shelf, carrying nutrients including iron (Fe) to surface waters, maintaining phytoplankton blooms. We present here full-depth profiles of dissolved and particulate Fe and manganese (Mn) from eight stations around PD, sampled in January and early February of 2015 and 2016, allowing the first detailed evaluation of Fe sources to the area's euphotic zone...
June 28, 2018: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/29760113/impact-of-sea-ice-melt-on-dimethyl-sulfide-sulfoniopropionate-inventories-in-surface-waters-of-marguerite-bay-west-antarctic-peninsula
#16
Jacqueline Stefels, Maria A van Leeuwe, Elizabeth M Jones, Michael P Meredith, Hugh J Venables, Alison L Webb, Sian F Henley
The Southern Ocean is a hotspot of the climate-relevant organic sulfur compound dimethyl sulfide (DMS). Spatial and temporal variability in DMS concentration is higher than in any other oceanic region, especially in the marginal ice zone. During a one-week expedition across the continental shelf of the West Antarctic Peninsula (WAP), from the shelf break into Marguerite Bay, in January 2015, spatial heterogeneity of DMS and its precursor dimethyl sulfoniopropionate (DMSP) was studied and linked with environmental conditions, including sea-ice melt events...
June 28, 2018: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/29760112/macronutrient-and-carbon-supply-uptake-and-cycling-across-the-antarctic-peninsula-shelf-during-summer
#17
Sian F Henley, Elizabeth M Jones, Hugh J Venables, Michael P Meredith, Yvonne L Firing, Ribanna Dittrich, Sabrina Heiser, Jacqueline Stefels, Julie Dougans
The West Antarctic Peninsula shelf is a region of high seasonal primary production which supports a large and productive food web, where macronutrients and inorganic carbon are sourced primarily from intrusions of warm saline Circumpolar Deep Water. We examined the cross-shelf modification of this water mass during mid-summer 2015 to understand the supply of nutrients and carbon to the productive surface ocean, and their subsequent uptake and cycling. We show that nitrate, phosphate, silicic acid and inorganic carbon are progressively enriched in subsurface waters across the shelf, contrary to cross-shelf reductions in heat, salinity and density...
June 28, 2018: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/29760109/shelf-ocean-exchange-and-hydrography-west-of-the-antarctic-peninsula-a-review
#18
REVIEW
C Moffat, M Meredith
The West Antarctic Peninsula (WAP) is a highly productive marine ecosystem where extended periods of change have been observed in the form of glacier retreat, reduction of sea-ice cover and shifts in marine populations, among others. The physical environment on the shelf is known to be strongly influenced by the Antarctic Circumpolar Current flowing along the shelf slope and carrying warm, nutrient-rich water, by cold waters flooding into the northern Bransfield Strait from the Weddell Sea, by an extensive network of glaciers and ice shelves, and by strong seasonal to inter-annual variability in sea-ice formation and air-sea interactions, with significant modulation by climate modes like El Niño-Southern Oscillation and the Southern Annular Mode...
June 28, 2018: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/29760108/anatomy-of-a-glacial-meltwater-discharge-event-in-an-antarctic-cove
#19
Michael P Meredith, Ulrike Falk, Anna Valeria Bers, Andreas Mackensen, Irene R Schloss, Eduardo Ruiz Barlett, Kerstin Jerosch, Adrián Silva Busso, Doris Abele
Glacial meltwater discharge from Antarctica is a key influence on the marine environment, impacting ocean circulation, sea level and productivity of the pelagic and benthic ecosystems. The responses elicited depend strongly on the characteristics of the meltwater releases, including timing, spatial structure and geochemical composition. Here we use isotopic tracers to reveal the time-varying pattern of meltwater during a discharge event from the Fourcade Glacier into Potter Cove, northern Antarctic Peninsula...
June 28, 2018: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/29759920/dysphonia-perceived-control-and-psychosocial-distress-a-qualitative-study
#20
Stephanie Misono, Caroline Haut, Liza Meredith, Patricia A Frazier, Ali Stockness, Deirdre D Michael, Lisa Butcher, Eileen M Harwood
OBJECTIVES: The purpose of this qualitative study was to examine relationships between psychological factors, particularly perceived control, and voice symptoms in adults seeking treatment for a voice problem. METHODS: Semistructured interviews of adult patients with a clinical diagnosis of muscle tension dysphonia were conducted and transcribed. Follow-up interviews were conducted as needed for further information or clarification. A multidisciplinary team analyzed interview content using inductive techniques...
May 11, 2018: Journal of Voice: Official Journal of the Voice Foundation
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