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euthyroid sick syndrome

Fábio V G Campanha, Denise Perone, Dijon H S de Campos, Renata de A M Luvizotto, Maria T De Síbio, Miriane de Oliveira, Regiane M C Olimpio, Fernanda C F Moretto, Carlos R Padovani, Gláucia M F S Mazeto, Antonio C Cicogna, Célia R Nogueira
Objective: The current study was aimed at analyzing sarcoplasmic reticulum Ca2+ ATPase (Serca2) and ryanodine receptor type 2 (Ryr2) gene expression in rats subjected to surgery that induced HF and were subsequently treated with T4 using physiological doses. Materials and methods: HF was induced in 18 male Wistar rats by clipping the ascending thoracic aorta to generate aortic stenosis (HFS group), while the control group (9-sham) underwent thoracotomy. After 21 weeks, the HFS group was subdivided into two subgroups...
October 10, 2016: Archives of Endocrinology and Metabolism
Olusoji Mayowa Ige, Kehinde Sola Akinlade, Sheu Kadiri Rahamon, Victory Fabian Edem, Olatunbosun Ganiyu Arinola
BACKGROUND: Mycobacterium tuberculosis and human immunodeficiency virus (HIV) are known to cause abnormal thyroid function. There is little information on whether HIV infection aggravates alteration of thyroid function in patients with MDR-TB. OBJECTIVES: This study was carried out to determine if HIV co-infection alters serum levels of thyroid hormones (T3, T4) and thyroid stimulating hormone (TSH) in patients with MDR-TB patients and to find out the frequency of subclinical thyroid dysfunction before the commencement of MDR-TB therapy...
June 2016: African Health Sciences
Sun Lee, Alan P Farwell
In this review, we discuss the characteristics, pathophysiology, and therapeutic implications of the euthyroid sick syndrome. Multiple mechanisms have been identified to contribute to the development of euthyroid sick syndrome, including alterations in the iodothyronine deiodinases, thyroid-stimulating hormone secretion, thyroid hormone binding to plasma protein, transport of thyroid hormone in peripheral tissues, and thyroid hormone receptor activity. The euthyroid sick syndrome appears to be a complex mix of physiologic adaptation and pathologic response to acute illness...
March 15, 2016: Comprehensive Physiology
Baris Afsar, Mahmut Ilker Yilmaz, Dimitrie Siriopol, Hilmi Umut Unal, Mutlu Saglam, Murat Karaman, Mustafa Gezer, Alper Sonmez, Tayfun Eyileten, Ibrahim Aydin, Salih Hamcan, Yusuf Oguz, Adrian Covic, Mehmet Kanbay
BACKGROUND AND AIMS: Abnormalities of thyroid function are commonly seen in chronic kidney disease (CKD) patients. They are associated with adverse clinical conditions such as atherosclerosis, endothelial dysfunction, inflammation and abnormal blood pressure variability. We investigated the association between thyroid disorders and endothelial function, assessed by flow-mediated dilatation (FMD) and carotid intima-media thickness (CIMT), and cardiovascular events (CVE) in CKD patients...
April 2, 2016: Journal of Nephrology
K V S Hari Kumar, Sandeep Kumar, Faiz M H Ahmad
BACKGROUND: Cerebrovascular disorders are common conditions leading to significant morbidity and mortality in the population. Occult endocrine disorders also contribute to the morbidity and we studied the prevalence of endocrine dysfunction in patients of cerebrovascular accident (CVA). MATERIALS AND METHODS: We evaluated 30 patients of CVA (aged 18-75, admission within 72 h of symptoms and positive neuroimaging) in this prospective, observational study. All subjects were assessed clinically and biochemically for hormonal dysfunction at admission and for mortality at the end of 1 month...
January 2016: Annals of Indian Academy of Neurology
M Mitkov, P Nyagolova, M Orbetzova
UNLABELLED: The purpose of this study was to analyze the relationship of the main hormonal and metabolic abnormalities in PCOS with different levels of TSH in the limits of its reference values. MATERIAL AND METHODS: The study involved 70 women with PCOS aged 16 to 39 years and BMI between 18.3 and 39.5 kg/m2 and a control group of 22 clinically healthy women, corresponding to age and BMI. In all of the participating women fasting plasma glucose, total cholesterol, HDL-cholesterol, triglycerides, insulin, TSH, FT4, TPO-Ab and Tg-Ab, LH, FSH, estradiol, Androstenedione, testosterone, SHBG, DHEA-S, prolactin, 17-hydroxyprogesterone were assessed...
2015: Akusherstvo i Ginekologii︠a︡
Neera Sharma, Lokesh Kumar Sharma, Deep Dutta, Adesh Kisanji Gadpayle, Atul Anand, Kumar Gaurav, Sabyasachi Mukherjee, Rahul Bansal
Background. Predictors of thyroid dysfunction in HIV are not well determined. This study aimed to determine the prevalence and predictors of thyroid dysfunction in HIV infected Indians. Methods. Consecutive HIV patients, 18-70 years of age, without any severe comorbid state, having at least 1-year follow-up at the antiretroviral therapy clinic, underwent clinical assessment and hormone assays. Results. From initially screened 527 patients, 359 patients (61.44 ± 39.42 months' disease duration), having good immune function [CD4 count >200 cell/mm(3): 90...
2015: Journal of Thyroid Research
Maria Del Rosario Muñoz-Ramirez, Claudia Alejandra Ortega-Valdez, Eduardo Murillo-Heredia
No abstract text is available yet for this article.
May 6, 2016: Medicina Clínica
Faiza A Qari
OBJECTIVE: To analyze alterations in thyroid function and the correlation between results of thyroid function test and mortality in medical and surgical intensive care unit (ICU) patients. It also aimed to evaluate the effect of thyroid dysfunction in ICU patients and their need for mechanical ventilation (MV). METHODS: A single-center, prospective, observational study was conducted on patients admitted to medical and surgical ICU between 2013-2014.. Clinical and paraclinical findings (free triiodothyronine, free thyroxine and thyroid stimulating hormone) were documented for all patients...
July 2015: Pakistan Journal of Medical Sciences Quarterly
Faiza Abdulaziz Qari
BACKGROUND: Thyroid hormone has the a major role in the cardiovascular system function and cardiac a As well as to maintain the cardiovascular homeostasis A slightly change ind thyroid status actually affects cardiovascular mortality hemodynamic. The background of this study was to define the prevalence of thyroid dysfunction in acute coronary syndrome (ACS). OBJECTIVES: The primary objective was to define the prevalence of thyroid dysfunction in acute coronary syndrome, including Non-ST Segment Elevation Myocardial Infarction (NSTEMI), ST-segment Elevation Myocardial Infarction (STEMI), and unstable angina groups...
July 2015: Iranian Red Crescent Medical Journal
Irene Paterniti, Marika Cordaro, Michele Navarra, Emanuela Esposito, Salvatore Cuzzocrea
INTRODUCTION: Traumatic brain injury (TBI) is a common cause of morbidity and mortality in the developed world. In particular, TBI is an important cause of death and disability in young adults with consequences ranging from physical disabilities to long-term cognitive, behavioural, psychological and social defects. AREAS COVERED: There is a large body of evidence that suggest that TBI conditions may adversely affect pituitary function in both the acute and chronic phases of recovery...
2015: Expert Opinion on Emerging Drugs
Karla Rocha Penteado, Júlio Cezar Uili Coelho, Mônica Beatriz Parolin, Jorge Eduardo Fouto Matias, Alexandre Coutinho Teixeira de Freitas
BACKGROUND: Thyroid dysfunction has been reported in most chronic illnesses including severe liver disease. These defects in thyroid hormone metabolism result in the sick euthyroid syndrome, also known as low T3 syndrome. OBJECTIVES: Our objective was to evaluate the thyroid function in patients with end stage liver disease prior and after deceased donor liver transplantation and to correlate thyroid hormonal changes with the MELD score (Model for End stage Liver Disease)...
April 2015: Arquivos de Gastroenterologia
Wojciech Zygner, Olga Gójska-Zygner, Piotr Bąska, Ewa Długosz
Low triiodothyronine (T3) syndrome, also named euthyroid sick syndrome or non-thyroidal illness syndrome, has been recognized in canine babesiosis caused by Babesia rossi, where it manifested by lowering of the serum thyrotropin (TSH), total thyroxin (TT4) and free thyroxin (FT4) concentrations. This syndrome has also been observed in critical diseases in humans and animals, and the severity of the disease is considered an important factor in lowering of thyroid hormone concentrations. Interleukin-6 (IL-6) plays a role in the development of low T3 syndrome by causing a decrease in deiodinases 1 and 2 activity and increased activity of deiodinase 3, enzymes involved in the conversion of thyroxin (T4) to T3...
June 30, 2015: Veterinary Parasitology
Emmely M de Vries, Eric Fliers, Anita Boelen
The 'sick euthyroid syndrome' or 'non-thyroidal illness syndrome' (NTIS) occurs in a large proportion of hospitalized patients and comprises a variety of alterations in the hypothalamus-pituitary-thyroid (HPT) axis that are observed during illness. One of the hallmarks of NTIS is decreased thyroid hormone (TH) serum concentrations, often viewed as an adaptive mechanism to save energy. Downregulation of hypophysiotropic TRH neurons in the paraventricular nucleus of the hypothalamus and of TSH production in the pituitary gland points to disturbed negative feedback regulation during illness...
June 2015: Journal of Endocrinology
Rohit Kumar Singh, Rohit Bhasin, Y S Bisht, K V S Hari Kumar
BACKGROUND: Leprosy is a chronic granulomatous disease and affects many internal organs in addition to the skin and peripheral nerves. Endocrine dysfunction is often silent and is often missed in patients of leprosy leading to significant morbidity. We studied the presence of occult endocrine disorders in leprosy patients and compared the same with disease parameters. MATERIALS AND METHODS: We evaluated 40 patients of leprosy (aged 18-70 years, any duration) in this cross-sectional, observational study...
May 2015: Indian Journal of Endocrinology and Metabolism
Valeriu Gheorghiţă, Alina Elena Barbu, Monica Livia Gheorghiu, Florin Alexandru Căruntu
Sepsis is a systemic, deleterious inflammatory host response triggered by an infective agent leading to severe sepsis, septic shock and multi-organ failure. The host response to infection involves a complex, organized and coherent interaction between immune, autonomic, neuroendocrine and behavioral systems. Recent data have confirmed that disturbances of the autonomic nervous and neuroendocrine systems could contribute to sepsis-induced organ dysfunction. Through this review, we aimed to summarize the current knowledge about the endocrine dysfunction as response to sepsis, specifically addressed to vasopressin, copeptin, cortisol, insulin and leptin...
March 2015: Germs
Satyakumar Thongam, Sunibala Keithelakpam, Tomba Y Singh, Ranbir L Singh, Amuba M Singh, Salam Ranabir
CONTEXT: Thyroid dysfunction has been reported in human immunodeficiency virus (HIV)-infected individuals including children. Some studies have reported that thyroid dysfunction may be a marker of severity or progression of HIV. AIMS: The aim was to study thyroid function in HIV-infected children with and without highly active anti-retroviral therapy (HAART). SETTINGS AND DESIGN: Cross-sectional study carried out at a teaching hospital with Anti-Retroviral Therapy Centre (Centre of Excellence) of National AIDS Control Organization...
March 2015: Indian Journal of Endocrinology and Metabolism
Yan-Yan Hu, Gui-Mei Li, Wei Wang
OBJECTIVES: To investigate characteristics of euthyroid sick syndrome (ESS) in children with diabetic ketoacidosis (DKA). METHODS: This retrospective study was carried out between May 2010 and April 2013 at the Pediatric Department of Shandong Provincial Hospital, Shandong University, Shandong, China. Diabetic ketoacidosis children were divided into 2 groups: euthyroidism (group one, n=30) and ESS (group 2, n=40). C-peptide, glycosylated hemoglobin (HbA1c), bicarbonate, anion gap (AG), free triiodothyronine (FT3), free thyroxine (FT4), and thyrotropin (TSH) levels were measured before and after 7 days of insulin treatment...
February 2015: Saudi Medical Journal
Th B Twickler, H P F Koppeschaar, M J M Cramer
No abstract text is available yet for this article.
December 2003: Netherlands Heart Journal
Sandeep Kharb, M K Garg, Pankaj Puri, Karninder S Brar, Aditi Pandit, Sharad Srivastava
INTRODUCTION: Liver is involved with the synthesis of carrier proteins and metabolism of various hormones and liver diseases may, therefore, be associated with various endocrine disturbances. This study was conducted to assess thyroid and gonadal function in subjects with acute hepatitis (AH), chronic liver disease (CLD), and those who had undergone liver transplantation (LT). MATERIALS AND METHODS: Patients with AH, CLD with Child-Pugh stage A (CLD-1) and Child-Pugh stage B or C (CLD-2), and LT seen at our tertiary level hospital were assessed clinically, biochemically, and for thyroid and gonadal functions besides 25 healthy controls...
January 2015: Indian Journal of Endocrinology and Metabolism
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