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Naringin AND NP cells

Nianhu Li, Camden Whitaker, Zhanwang Xu, Michael Heggeness, Shang-You Yang
BACKGROUND: Over half the population of the world will suffer moderate or severe low back pain (LBP) during their life span. Studies have shown that naringin, a major flavonoid in grapefruit and an active compound extracted from a Chinese herbal medicine (Rhizoma Drynariae) possesses many pharmacological effects. PURPOSE: To evaluate the influence of naringin on the growth of degenerative human nucleus pulposus (NP) cells, and its repair effects on protein and gene expressions of the cells...
May 18, 2016: Spine Journal: Official Journal of the North American Spine Society
Gopinath Kulasekaran, Sudhandiran Ganapasam
UNLABELLED: Oxidative stress and mitochondrial dysfunction are implicated in neuronal apoptosis associated with Huntington's disease. Naringin is the flavanone present in grapefruit and related citrus species possess diverse pharmacological and therapeutic properties including antioxidant, anti-apoptotic, and neuroprotective properties. The aim of this study was to investigate the protective effect of naringin on 3-nitropropionic acid (3-NP)-induced neurotoxicity in pheochromocytoma cells (PC12) cells and to explore its mechanism of action...
November 2015: Molecular and Cellular Biochemistry
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