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https://www.readbyqxmd.com/read/28225043/prevention-of-tumorigenesis-in-mice-by-exercise-is-dependent-on-strain-background-and-timing-relative-to-carcinogen-exposure
#1
Scott A Kelly, Liyang Zhao, Kuo-Chen Jung, Kunjie Hua, David W Threadgill, Yunjung Kim, Fernando Pardo Manuel de Villena, Daniel Pomp
Among cancer diagnoses, colorectal cancer (CRC) is prevalent, with a lifetime risk of developing CRC being approximately 5%. Population variation surrounding the mean risk of developing CRCs has been associated with both inter-individual differences in genomic architecture and environmental exposures. Decreased risk of CRC has been associated with physical activity, but protective responses are variable. Here, we utilized a series of experiments to examine the effects of genetic background (strain), voluntary exercise (wheel running), and their interaction on azoxymethane (AOM)-induced intestinal tumor number and size in mice...
February 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28224100/early-infant-male-circumcision-systematic-review-risk-benefit-analysis-and-progress-in-policy
#2
Brian J Morris, Sean E Kennedy, Alex D Wodak, Adrian Mindel, David Golovsky, Leslie Schrieber, Eugenie R Lumbers, David J Handelsman, John B Ziegler
AIM: To determine whether recent evidence-based United States policies on male circumcision (MC) apply to comparable Anglophone countries, Australia and New Zealand. METHODS: Articles in 2005 through 2015 were retrieved from PubMed using the keyword "circumcision" together with 36 relevant subtopics. A further PubMed search was performed for articles published in 2016. Searches of the EMBASE and Cochrane databases did not yield additional citable articles. Articles were assessed for quality and those rated 2+ and above according to the Scottish Intercollegiate Grading System were studied further...
February 8, 2017: World Journal of Clinical Pediatrics
https://www.readbyqxmd.com/read/28223467/hypertension-in-pregnancy-and-offspring-cardiovascular-risk-in-young-adulthood-prospective-and-sibling-studies-in-the-hunt-study-nord-tr%C3%A3-ndelag-health-study-in-norway
#3
Ingvild V Alsnes, Lars J Vatten, Abigail Fraser, Johan Håkon Bjørngaard, Janet Rich-Edwards, Pål R Romundstad, Bjørn O Åsvold
Women with hypertensive disorders in pregnancy are at increased lifetime risk for cardiovascular disease. We examined the offspring's cardiovascular risk profile in young adulthood and their siblings' cardiovascular risk profile. From the HUNT study (Nord-Trøndelag Health Study) in Norway, 15 778 participants (mean age: 29 years), including 210 sibling groups, were linked to information from the Medical Birth Registry of Norway. Blood pressure, anthropometry, serum lipids, and C-reactive protein were assessed...
February 21, 2017: Hypertension
https://www.readbyqxmd.com/read/28222941/diabetes-and-lifetime-risk-of-stroke-and-subtypes-in-an-urban-middle-aged-population
#4
Tanvir Chowdhury Turin, Tomonori Okamura, Nahid Rumana, Arfan Raheen Afzal, Makoto Watanabe, Aya Higashiyama, Yoko M Nakao, Michikazu Nakai, Misa Takegami, Kunihiro Nishimura, Yoshihiro Kokubo, Akira Okayama, Yoshihiro Miyamoto
AIMS: Lifetime risk (LTR) is defined as the cumulative probability of developing a disease in one's remaining lifetime from a given index age. The impact of diabetes on the LTR of stroke events in Asians, where stroke incidence is higher than for Westerners, has not been estimated yet. These estimates can be useful for diabetes knowledge translation activities. METHODS: All participants who were stroke-free at baseline in the Suita Study, a cohort study of cardiovascular diseases in Japan, were included in the study sample...
February 10, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28222820/the-cross-national-epidemiology-of-specific-phobia-in-the-world-mental-health-surveys
#5
K J Wardenaar, C C W Lim, A O Al-Hamzawi, J Alonso, L H Andrade, C Benjet, B Bunting, G de Girolamo, K Demyttenaere, S E Florescu, O Gureje, T Hisateru, C Hu, Y Huang, E Karam, A Kiejna, J P Lepine, F Navarro-Mateu, M Oakley Browne, M Piazza, J Posada-Villa, M L Ten Have, Y Torres, M Xavier, Z Zarkov, R C Kessler, K M Scott, P de Jonge
BACKGROUND: Although specific phobia is highly prevalent, associated with impairment, and an important risk factor for the development of other mental disorders, cross-national epidemiological data are scarce, especially from low- and middle-income countries. This paper presents epidemiological data from 22 low-, lower-middle-, upper-middle- and high-income countries. METHOD: Data came from 25 representative population-based surveys conducted in 22 countries (2001-2011) as part of the World Health Organization World Mental Health Surveys initiative (n = 124 902)...
February 22, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28222714/screening-prevalence-and-risk-factors-for-cervical-lesions-among-hiv-positive-and-hiv-negative-women-in-swaziland
#6
Pauline E Jolly, Simangele Mthethwa-Hleta, Luz A Padilla, Jessica Pettis, ShaCoria Winston, Tomi F Akinyemiju, Hannah J Turner, Amarachi Ejiawoko, Raina Brooks, Lena Preko, Peter O Preko
BACKGROUND: Cervical Cancer (CC) is the number one cancer among women in sub-Saharan Africa. Although CC is preventable, most women in developing countries do not have access to screening. METHODS: This cross-sectional study was conducted to determine the prevalence and risk factors for cervical lesions using visual inspection with acetic acid (VIA) among 112 HIV positive and 161 negative women aged 18-69 years. RESULTS: The presence of cervical lesions was greater among HIV positive (22...
February 21, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28222713/the-mental-health-status-of-refugees-and-asylum-seekers-attending-a-refugee-health-clinic-including-comparisons-with-a-matched-sample-of-australian-born-residents
#7
Frances Shawyer, Joanne C Enticott, Andrew A Block, I-Hao Cheng, Graham N Meadows
BACKGROUND: The aim of this study was to survey refugees and asylum-seekers attending a Refugee Health Service in Melbourne, Australia to estimate the prevalence of psychiatric disorders based on screening measures and with post-traumatic stress disorder (PTSD) specifically highlighted. A secondary aim was to compare the prevalence findings with Australian-born matched comparators from the 2007 National Survey of Mental Health and Well-Being. METHODS: We conducted a cross-sectional survey of 135 refugees and asylum-seeker participants using instruments including Kessler-10 (K10) and PTSD-8 to obtain estimates of the prevalence of mental disorders...
February 21, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28222224/commentary-on-kerr-et%C3%A2-al-2017-more-evidence-that-social-and-health-limitations-in-childhood-increase-the-risk-of-lifetime-abstention-from-alcohol
#8
Linda Ng Fat
Childhood poverty and work-related health limitations were found to increase the risk of being a lifetime abstainer from alcohol, according to a new study by Kerr and colleagues (Kerr et al., 2017). Findings were based on analyses of the 1979 National Longitudinal Survey of Youth Cohort, a nationally representative prospective study following 6,111 youths aged 14 to 21 in private residences in the US. Strengths of the study include a derivation of lifetime abstention based on successive information from youth up to age 55, meaning lifetime abstention was not subject to validity or recall issues, as has been found with the identification of being a lifetime abstainer at a later time-point (Caldwell et al...
February 21, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28221097/supplemental-breast-mr-imaging-screening-of-women-with-average-risk-of-breast-cancer
#9
Christiane K Kuhl, Kevin Strobel, Heribert Bieling, Claudia Leutner, Hans H Schild, Simone Schrading
Purpose To investigate the utility and accuracy of breast magnetic resonance (MR) imaging as a supplemental screening tool in women at average risk for breast cancer and to investigate the types of cancer detected with MR imaging screening. Materials and Methods This prospective observational study was conducted at two academic breast centers in women aged 40-70 years without breast cancer-associated risk factors (lifetime risk <15%). Between January 2005 and December 2013, women with at least minimal residual breast tissue (American College of Radiology categories A-D) and normal conventional imaging findings (screening mammography with or without screening ultrasonography [US]) were invited to undergo supplemental MR imaging screening...
February 21, 2017: Radiology
https://www.readbyqxmd.com/read/28219714/relationship-between-physical-activity-and-hip-pain-in-persons-with-and-without-cam-or-pincer-morphology-a-population-based-case-control-study
#10
Jacek A Kopec, Jolanda Cibere, Linda C Li, Charlie Zhang, Morgan Barber, Hong Qian, Hubert Wong, Gavin Steininger, Helen Prlic, Jacqueline Simatovic, Charles Ratzlaff, Eric C Sayre, Joanna Ye, Bruce B Forster, John M Esdaile
OBJECTIVES: The purpose of the study was to determine if physical activity (PA) is a risk factor for persistent or recurrent hip pain in young and middle-aged persons with and without radiographic findings of cam or pincer morphology (CPM). METHODS: A population sample of persons aged 20-49 with (cases) and without (controls) hip pain in Metro Vancouver, Canada, was selected through random digit dialing. Self-reported PA was expressed as average energy expenditure (MET-hours) per year, over lifetime...
February 17, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28219238/public-health-risk-of-arsenic-species-in-chicken-tissues-from-live-poultry-markets-of-guangdong-province-china
#11
Yuanan Hu, Wenfeng Zhang, Hefa Cheng, Shu Tao
Arsenic-based feed additives, such as roxarsone (ROX), are still legally and widely used in food animal production in many countries. This study was conducted to systematically characterize the content and speciation of arsenic in chicken tissues from live poultry markets and in commercial chicken feeds in Guangdong, a major poultry production and consumption province in China, and to assess the corresponding public health risk. The total arsenic contents in the commercial feeds could be modeled as a mixture of two log-normal distributions (geometric means: 0...
February 21, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28217902/moving-towards-population-based-genetic-risk-prediction-for-ovarian-cancer
#12
Belinda Rahman, Lucy Side, Sahra Gibbon, Susanne F Meisel, Lindsay Fraser, Sue Gessler, Jane Wardle, Anne Lanceley
Ovarian cancer is the fifth most common cancer in UK women, and the leading cause of gynaecological cancer death. Five-year survival rates, of around 40%, have shown little improvement despite recent advances in cancer treatment. Mutations in the cancer susceptibility genes BRCA1 and BRCA2 confer lifetime risks of breast and ovarian cancer of up to 80% and 40% respectively. The traditional approach of using cancer family history to select patients for genetic testing is being challenged; up to 44% of BRCA mutation carriers do not have a significant family history...
February 19, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28216809/healing-ulcers-and-preventing-their-recurrences-in-the-diabetic-foot
#13
S Raja Sabapathy, Madhu Periasamy
Fifteen percent of people with diabetes develop an ulcer in the course of their lifetime. Eighty-five percent of the major amputations in diabetes mellitus are preceded by an ulcer. Management of ulcers and preventing their recurrence is important for the quality of life of the individual and reducing the cost of care of treatment. The main causative factors of ulceration are neuropathy, vasculopathy and limited joint mobility. Altered bio-mechanics due to the deformities secondary to neuropathy and limited joint mobility leads to focal points of increased pressure, which compromises circulation leading to ulcers...
September 2016: Indian Journal of Plastic Surgery: Official Publication of the Association of Plastic Surgeons of India
https://www.readbyqxmd.com/read/28216432/epigenetic-modification-by-dietary-factors-implications-in-metabolic-syndrome
#14
REVIEW
Jae-Ho Park, Soon-Hee Kim, Myeong Soo Lee, Myung-Sunny Kim
Dietary factors play a role in normal biological processes and are involved in the regulation of pathological progression over a lifetime. Evidence has emerged indicating that dietary factor-dependent epigenetic modifications can significantly affect genome stability and the expression of mRNA and proteins, which are involved in metabolic dysfunction. Since metabolic syndrome is a progressive phenotype characterized by insulin resistance, obesity, hypertension, dyslipidemia, or type 2 diabetes, gene-diet interactions are important processes involved in the initiation of particular symptoms of metabolic syndrome and their progression...
February 16, 2017: Molecular Aspects of Medicine
https://www.readbyqxmd.com/read/28216129/social-media-use-and-its-association-with-sexual-risk-and-parental-monitoring-among-a-primarily-hispanic-adolescent-population
#15
Dina L Romo, Chelsea Garnett, Alayna P Younger, Melissa S Stockwell, Karen Soren, Marina Catallozzi, Natalie Neu
STUDY OBJECTIVE: This study assesses the association between social media (SM) use with sexual risk, and with parental monitoring among Hispanic adolescents. DESIGN: Self-administered anonymous survey SETTING: Urban primary care clinics PARTICIPANTS: 13-21 year olds primarily Hispanic adolescents MAIN OUTCOME MEASURES: Chi-square and regression analyses controlling for age and gender assessed associations between SM use or sexting and sexual behaviors (kissing, touching genitals, vaginal oral, and anal sex), sexual risk (>4 lifetime partners, >1 recent partner, inconsistent condom use and history of STI diagnosis) and contraceptive use...
February 16, 2017: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/28216025/pi3k-akt-mtor-inhibitors-in-breast-cancers-from-tumor-cell-signaling-to-clinical-trials
#16
REVIEW
Dey Nandini, De Pradip, Leyland-Jones Brian
Breast cancer (BC) is the most common women cancer and second most common cause of cancer death in women. A woman living in the Unites States has 12.3% lifetime risk of being diagnosed with BC. From the genomics point of view, the most common three subtypes of BC encountered in clinics are HR+, HER2+, and TNBC or basal-like BC. Estrogen receptor (ER) status or HER2 amplification or chemotherapy is not sufficient to understand the underlying mechanisms of disease progression and resistance (de novo or acquire)...
February 16, 2017: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28214794/cost-effectiveness-of-intensifying-lipid-lowering-therapy-with-statins-based-on-individual-absolute-benefit-in-coronary-artery-disease-patients
#17
Manon C Stam-Slob, Yolanda van der Graaf, Jacoba P Greving, Jannick A N Dorresteijn, Frank L J Visseren
BACKGROUND: A validated prediction model estimates the absolute benefit of intensive versus standard lipid-lowering therapy (LLT) with statins on next major cardiovascular events for individual patients with coronary artery disease. We aimed to assess whether targeting intensive LLT therapy to coronary artery disease patients with the highest predicted absolute benefit is cost-effective compared to treating all with standard or all with intensive LLT. METHODS AND RESULTS: A lifetime Markov model was constructed for coronary artery disease patients (n=10 000) with mean age 61 years...
February 18, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28214013/lifetime-prevalence-and-incidence-of-sexual-victimization-of-adolescents-in-institutional-care
#18
Marc Allroggen, Thea Rau, Jeannine Ohlert, Jörg M Fegert
The frequency of sexual victimization in high-risk populations like adolescents in institutional care has hardly been studied. In this study, we report lifetime prevalence and incidence from a nationwide German sample including 322 adolescents (mean age 16.69 years, 43% female) from 20 residential care facilities and 12 boarding schools. Lifetime prevalence for severe sexual victimization (in and outside of institution) was 46.7% for girls and 8.0% for boys. Moreover, 5% of all adolescents experienced severe sexual victimization for the first time after they were admitted to the current institution (mean duration of stay in the current institution 3...
February 14, 2017: Child Abuse & Neglect
https://www.readbyqxmd.com/read/28213670/emerging-genotype-phenotype-relationships-in-patients-with-large-nf1-deletions
#19
REVIEW
Hildegard Kehrer-Sawatzki, Victor-Felix Mautner, David N Cooper
The most frequent recurring mutations in neurofibromatosis type 1 (NF1) are large deletions encompassing the NF1 gene and its flanking regions (NF1 microdeletions). The majority of these deletions encompass 1.4-Mb and are associated with the loss of 14 protein-coding genes and four microRNA genes. Patients with germline type-1 NF1 microdeletions frequently exhibit dysmorphic facial features, overgrowth/tall-for-age stature, significant delay in cognitive development, large hands and feet, hyperflexibility of joints and muscular hypotonia...
February 17, 2017: Human Genetics
https://www.readbyqxmd.com/read/28213577/economic-evaluation-of-universal-prenatal-hiv-screening-compared-with-current-at-risk-policy-in-a-very-low-prevalence-country
#20
Michal Chowers, Oren Shavit
OBJECTIVES: Our objective was to economically evaluate universal HIV prenatal screening in Israel, a very low prevalence country (0.1%), compared with the current policy of testing only women belonging to high-risk (HR) groups. DESIGN: A cost-effectiveness analytical model was constructed. Life expectancies, direct medical costs and utility weights of an HIV-positive newborn and a healthy newborn were derived from the literature. Screening was assessed using fourth-generation combo tests...
March 2017: Sexually Transmitted Infections
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