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https://www.readbyqxmd.com/read/27925506/aliphatic-and-polycyclic-aromatic-hydrocarbons-pahs-in-soils-of-the-northwest-qinling-mountains-patterns-potential-risk-and-an-appraisal-of-the-pah-ratios-to-infer-their-source
#1
Yanhong Liu, Yingqin Wu, Yanqing Xia, Tianzhu Lei, Chuntao Tian, Xiaohuan Hou
Surface soils from the tourist areas of the northwest Qinling Mountains were analyzed to determine the concentrations, probable sources and potential risks of hydrocarbons. Concentrations of aliphatic and aromatic hydrocarbons ranged from 4.18 to 3240 ng g(-1) and 0.0462 to 101 ng g(-1) dry weight, respectively. The extent of soil contamination by hydrocarbons was generally typified by unpolluted to slightly polluted levels. The incremental lifetime cancer risks (ILCRs) for exposure to soil-borne PAHs indicated complete safety for tourists...
December 7, 2016: Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering
https://www.readbyqxmd.com/read/27925175/to-expand-coverage-or-increase-frequency-quantifying-the-tradeoffs-between-equity-and-efficiency-facing-cervical-cancer-screening-programs-in-low-resource-settings
#2
Nicole G Campos, Vivien Tsu, Jose Jeronimo, Mercy Mvundura, Kyueun Lee, Jane J Kim
Cervical cancer is a leading cause of cancer death worldwide, with 85% of the disease burden residing in less developed regions. To inform evidence-based decision-making as cervical cancer screening programs are planned, implemented, and scaled in low- and middle-income countries, we used cost and test performance data from the START-UP demonstration project in Uganda and a microsimulation model of HPV infection and cervical carcinogenesis to quantify the health benefits, distributional equity, cost-effectiveness, and financial impact of either 1) improving access to cervical cancer screening or 2) increasing the number of lifetime screening opportunities for women who already have access...
December 7, 2016: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/27923553/anxiety-and-depression-in-caregivers-of-individuals-with-celiac-disease-a-population-based-study
#3
Jonas F Ludvigsson, Abhik Roy, Benjamin Lebwohl, Peter H R Green, Louise Emilsson
BACKGROUND & AIMS: Partner burden is common in celiac disease (CD), but it is unclear if parents of children with CD have increased burden, and if this may translate into depression and anxiety meriting healthcare. METHODS: Nationwide population-based study of 41,753 parents and spouses ("caregivers") to 29,096 celiac patients and 215,752 caregivers to 144,522 matched controls. Caregivers were identified from the Swedish Total Population Register, and linked to data on psychiatric disease in the National Patient Registry...
November 16, 2016: Digestive and Liver Disease
https://www.readbyqxmd.com/read/27923390/the-rapid-ctca-trial-rapid-assessment-of-potential-ischaemic-heart-disease-with-ctca-a-multicentre-parallel-group-randomised-trial-to-compare-early-computerised-tomography-coronary-angiography-versus-standard-care-in-patients-presenting-with-suspected-or-confirmed
#4
Alasdair J Gray, Carl Roobottom, Jason E Smith, Steve Goodacre, Katherine Oatey, Rachel O'Brien, Robert F Storey, Lumine Na, Steff C Lewis, Praveen Thokala, David E Newby
BACKGROUND: Emergency department attendances with chest pain requiring assessment for acute coronary syndrome (ACS) are a major global health issue. Standard assessment includes history, examination, electrocardiogram (ECG) and serial troponin testing. Computerised tomography coronary angiography (CTCA) enables additional anatomical assessment of patients for coronary artery disease (CAD) but has only been studied in very low-risk patients. This trial aims to investigate the effect of early CTCA upon interventions, event rates and health care costs in patients with suspected/confirmed ACS who are at intermediate risk...
December 7, 2016: Trials
https://www.readbyqxmd.com/read/27920973/consumption-of-caffeinated-energy-drinks-among-youth-and-young-adults-in-canada
#5
Jessica L Reid, Cassondra McCrory, Christine M White, Chantal Martineau, Pat Vanderkooy, Nancy Fenton, David Hammond
The growing market for caffeinated energy drinks (CEDs) has caused concern about excessive caffeine intake and potential adverse effects, particularly among young people. The current study examined patterns of CED consumption among youth and young adults in Canada, using data from a national online survey conducted in October 2014. Data from a non-probability sample of 2040 respondents aged 12-24 from a consumer panel was weighted to national proportions; measures of CED consumption were estimated, including prevalence, excessive daily consumption, and context for use (locations and reasons)...
March 2017: Preventive Medicine Reports
https://www.readbyqxmd.com/read/27920223/correlation-between-pubic-hair-grooming-and-stis-results-from-a-nationally-representative-probability-sample
#6
E Charles Osterberg, Thomas W Gaither, Mohannad A Awad, Matthew D Truesdale, Isabel Allen, Siobhan Sutcliffe, Benjamin N Breyer
OBJECTIVE: STIs are the most common infections among adults. Concurrently, pubic hair grooming is prevalent. Small-scale studies have demonstrated a relationship between pubic hair grooming and STIs. We aim to examine this relationship in a large sample of men and women. DESIGN: We conducted a probability survey of US residents aged 18-65 years. The survey ascertained self-reported pubic hair grooming practices, sexual behaviours and STI history. We defined extreme grooming as removal of all pubic hair more than 11 times per year and high-frequency grooming as daily/weekly trimming...
December 5, 2016: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/27919498/association-between-exposure-to-farm-animals-and-pets-and-risk-of-multiple-sclerosis
#7
Dylan Siejka, Bruce Taylor, Anne-Louise Ponsonby, Terence Dwyer, Ingrid van der Mei
PURPOSE: There exists inconsistent evidence regarding animals including pets as risk factors for the development of Multiple Sclerosis (MS). We investigated the association between farm animals and pets as possible environmental factors in MS development. METHODS: Population based case-control study with 136 clinically definite MS cases and 272 controls randomly chosen from the community matched on sex and age. Data was collected from both questionnaire and a lifetime calendar detailing residence, occupation and pet/animal exposure over the course of participant's lives...
November 2016: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/27919060/estimation-of-quantitative-levels-of-diesel-exhaust-exposure-and-the-health-impact-in-the-contemporary-australian-mining-industry
#8
Susan Peters, Nicholas de Klerk, Alison Reid, Lin Fritschi, Aw Bill Musk, Roel Vermeulen
OBJECTIVES: To estimate quantitative levels of exposure to diesel exhaust expressed by elemental carbon (EC) in the contemporary mining industry and to describe the excess risk of lung cancer that may result from those levels. METHODS: EC exposure has been monitored in Western Australian miners since 2003. Mixed-effects models were used to estimate EC levels for five surface and five underground occupation groups (as a fixed effect) and specific jobs within each group (as a random effect)...
November 15, 2016: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/27919008/phenotype-analysis-of-male-transgenic-mice-overexpressing-mutant-igfbp-2-lacking-the-cardin-weintraub-sequence-motif-reduced-expression-of-synaptic-markers-and-myelin-basic-protein-in-the-brain-and-a-lower-degree-of-anxiety-like-behaviour
#9
N Schindler, J Mayer, S Saenger, U Gimsa, C Walz, J Brenmoehl, D Ohde, E Wirthgen, A Tuchscherer, V C Russo, M Frank, T Kirschstein, F Metzger, A Hoeflich
Brain growth and function are regulated by insulin-like growth factors I and II (IGF-I and IGF-II) but also by IGF-binding proteins (IGFBPs), including IGFBP-2. In addition to modulating IGF activities, IGFBP-2 interacts with a number of components of the extracellular matrix and cell membrane via a Cardin-Weintraub sequence or heparin binding domain (HBD1). The nature and the signalling elicited by these interactions are not fully understood. Here, we examined transgenic mice (H1d-hBP2) overexpressing a mutant human IGFBP-2 that lacks a specific heparin binding domain (HBD1) known as the Cardin-Weintraub sequence...
November 16, 2016: Growth Hormone & IGF Research
https://www.readbyqxmd.com/read/27918975/epigenetic-control-of-%C3%AE-cell-function-and-failure
#10
REVIEW
Diana Bernstein, Maria L Golson, Klaus H Kaestner
Type 2 diabetes is a highly heritable disease, but only ∼15% of this heritability can be explained by known genetic variant loci. In fact, body mass index is more predictive of diabetes than any of the common risk alleles identified by genome-wide association studies. This discrepancy may be explained by epigenetic inheritance, whereby changes in gene regulation can be passed along to offspring. Epigenetic changes throughout an organism's lifetime, based on environmental factors such as chemical exposures, diet, physical activity, and age, can also affect gene expression and susceptibility to diabetes...
November 21, 2016: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/27918784/association-of-long-term-low-intensity-smoking-with-all-cause-and-cause-specific-mortality-in-the-national-institutes-of-health-aarp-diet-and-health-study
#11
Maki Inoue-Choi, Linda M Liao, Carolyn Reyes-Guzman, Patricia Hartge, Neil Caporaso, Neal D Freedman
Importance: A growing proportion of US smokers now smoke fewer than 10 cigarettes per day (CPD), and that proportion will likely rise in the future. The health effects of smoking only a few CPD over one's lifetime are less understood than are the effects of heavier smoking, although many smokers believe that their level is modest. Objective: To evaluate the associations of long-term smoking of fewer than 1 or 1 to 10 CPD (low intensity) with all-cause and cause-specific mortality compared with never smoking cigarettes...
December 5, 2016: JAMA Internal Medicine
https://www.readbyqxmd.com/read/27917531/burden-of-herpes-zoster-and-postherpetic-neuralgia-in-japanese-adults-60-years-of-age-or-older-results-from-an-observational-prospective-physician-practice-based-cohort-study
#12
Keiko Sato, Koichi Adachi, Hiroyuki Nakamura, Kazuhiro Asano, Akihiro Watanabe, Riri Adachi, Mariko Kiuchi, Keiju Kobayashi, Taizo Matsuki, Toshihiko Kaise, Kusuma Gopala, Katsiaryna Holl
Approximately one in three persons will develop herpes zoster during their lifetime, and it can lead to serious complications such as postherpetic neuralgia. However, evidence on burden of herpes zoster and postherpetic neuralgia in Japan is limited. This prospective, observational, multicenter, physician practice-based cohort study was conducted in Kushiro, Hokkaido, Japan (Clinicaltrials.gov identifier NCT01873365) to assess the incidence and hospitalization rates of herpes zoster, and the proportion, clinical burden and risk factors for postherpetic neuralgia in adults aged 60 years or more...
December 5, 2016: Journal of Dermatology
https://www.readbyqxmd.com/read/27917486/school-based-positive-youth-development-a-systematic-review-of-the-literature
#13
Tess Curran, Lisa Wexler
BACKGROUND: The values, perspectives, and behavior patterns that begin in adolescence can continue throughout one's life. Because of these lifetime effects, much research has focused on adolescent risk and prevention, but a new body of knowledge investigates protective factors and strengths. Positive youth development (PYD) increases internal and external assets during adolescence and is often based within communities. This review, however, focuses on school-based PYD interventions because these institutions are the largest youth-serving institutions in the country...
January 2017: Journal of School Health
https://www.readbyqxmd.com/read/27917463/decision-making-regarding-mammography-screening-for-older-women
#14
Mara A Schonberg
The population is aging, and breast cancer incidence increases with age, peaking between the ages of 75 and 79. However, it is not known whether mammography screening helps women aged 75 and older live longer because they have not been included in randomized controlled trials evaluating mammography screening. Guidelines recommend that older women with less than a 10-year life expectancy not be screened because it takes approximately 10 years before a screen-detected breast cancer may affect an older woman's survival...
December 5, 2016: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/27916277/the-cost-effectiveness-of-hla-b-5801-screening-to-guide-initial-urate-lowering-therapy-for-gout-in-the-united-states
#15
Eric Jutkowitz, Maureen Dubreuil, Na Lu, Karen M Kuntz, Hyon K Choi
OBJECTIVE: Positive HLA-B*5801 carriers are at greater risk of experiencing rare but severe allopurinol hypersensitivity syndrome (AHS) [i.e., Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN)]; however, HLA-B*5801 prevalence and AHS risk vary by race/ethnicity. We evaluated the cost-effectiveness of HLA-B*5801 testing according to race/ethnicity in the United States. METHODS: We determined the cost-effectiveness of universal testing for HLA-B*5801 compared to no testing prior to the initiation of allopurinol per US major race/ethnicity groups...
November 1, 2016: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/27915406/a-new-era-for-drinking-epidemiological-evidence-on-adolescent-male-female-differences-in-drinking-incidence-in-the-united-states-and-europe
#16
Hui G Cheng, James C Anthony
PURPOSE: We seek answers to three questions about adolescent risk of starting to drink alcoholic beverages: (1) in new United States (US) data, can we reproduce a recently discovered female excess risk? (2) has a female excess risk emerged in European countries? and (3) might the size of country-level female-male differences (FMD) be influenced by macro-level gender equality and development processes? METHODS: Estimates are from US and European surveys of adolescents, 2010-2014...
December 3, 2016: Social Psychiatry and Psychiatric Epidemiology
https://www.readbyqxmd.com/read/27914770/cigarette-smoking-and-mortality-in-adults-aged-70-years-and-older-results-from-the-nih-aarp-cohort
#17
Sarah H Nash, Linda M Liao, Tamara B Harris, Neal D Freedman
INTRODUCTION: Tobacco use remains a leading modifiable cause of cancer incidence and premature mortality in the U.S. and globally. Despite increasing life expectancy worldwide, less is known about the effects of cigarette smoking on older populations. This study sought to determine the effects of smoking on mortality in older age. METHODS: Associations of mortality with self-reported age at smoking cessation, age at smoking initiation, and amount smoked after age 70 years were examined in 160,113 participants of the NIH-AARP Diet and Health Study aged >70 years...
November 22, 2016: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/27914102/examining-temporal-effects-on-cancer-risk-in-the-international-nuclear-workers-study-inworks
#18
Robert D Daniels, Stephen J Bertke, David B Richardson, Elisabeth Cardis, Michael Gillies, Jacqueline A O'Hagan, Richard Haylock, Dominique Laurier, Klervi Leuraud, Monika Moissonnier, Isabelle Thierry-Chef, Ausrele Kesminiene, Mary K Schubauer-Berigan
The paper continues the series of publications from the International Nuclear Workers Study cohort (INWORKS) that comprises 308,297 workers from France, the United Kingdom and the United States, providing 8.2 million person-years of observation from a combined follow-up period (at earliest 1944 to at latest 2005). These workers' external radiation exposures were primarily to photons, resulting in an estimated average career absorbed dose to the colon of 17.4 milligray. The association between cumulative ionizing radiation dose and cancer mortality was evaluated in general relative risk models that describe modification of the excess relative risk (ERR) per gray (Gy) by time since exposure and age at exposure...
December 3, 2016: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/27913688/left-ventricle-transcriptomic-analysis-reveals-connective-tissue-accumulation-associates-with-initial-age-dependent-decline-in-v%C3%AC-o2peak-from-its-lifetime-apex
#19
Gregory N Ruegsegger, Ryan G Toedebusch, Joshua F Braselton, Thomas E Childs, Frank W Booth
Peak oxygen consumption (V̇O2peak) strongly predicts morbidity and mortality better than other established risk factors, yet mechanisms associated with its age-associated decline are unknown. Our lab has shown that V̇O2peak first begins to decrease at the same age of 19-20 weeks old in both sedentary and wheel-running, female Wistar rats (Toedebusch et al., Physiol Genomics. 48:101-15, 2016). Here, we employed a total systemic approach using unsupervised interrogation of mRNA with RNA-sequencing. The purpose of our study was to analyze transcriptomic profiles from both sedentary (SED) and wheel-running (RUN) conditions as a strategy to identify pathways in the left ventricle that may contribute to the initial reductions in V̇O2peak occurring between 19 and 27 weeks of age...
December 2, 2016: Physiological Genomics
https://www.readbyqxmd.com/read/27913580/responding-to-challenges-for-people-with-psychotic-illness-updated-evidence-from-the-survey-of-high-impact-psychosis
#20
REVIEW
Vera A Morgan, Anna Waterreus, Vaughan Carr, David Castle, Martin Cohen, Carol Harvey, Cherrie Galletly, Andrew Mackinnon, Patrick McGorry, John J McGrath, Amanda L Neil, Suzy Saw, Johanna C Badcock, Debra L Foley, Geoff Waghorn, Sarah Coker, Assen Jablensky
OBJECTIVE: The objective is to summarise recent findings from the 2010 Australian Survey of High Impact Psychosis (SHIP) and examine their implications for future policy and planning to improve mental health, physical health and other circumstances of people with a psychotic disorder. METHODS: Survey of High Impact Psychosis collected nationally representative data on 1825 people with psychotic illness. Over 60 papers have been published covering key challenges reported by participants: financial problems, loneliness and social isolation, unemployment, poor physical health, uncontrolled symptoms of mental illness, and lack of stable, suitable housing...
December 1, 2016: Australian and New Zealand Journal of Psychiatry
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