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Urtica dioica

Gianpiero Bonetti, Paola Tedeschi, Giuseppe Meca, Davide Bertelli, Jordi Mañes, Vincenzo Brandolini, Annalisa Maietti
Nettle (Urtica dioica L.) is a well-known plant with a wide historical background use of stems, roots and leaves. Nettle leaves are an excellent source of phenolic compounds, principally 3-caffeoylquinic acid (3-CQA), caffeoylmalic acid (CMA) and rutin. The aim of this work was to evaluate the bioaccessibility (BAC), the bioavailability (BAV) and the antioxidant activity of nettle phenolic compounds present in foods and supplements. The BAC of nettle phenolics was evaluated with an in vitro dynamic digestion of real food matrices: the type of food matrix and chemical characteristic affected the kinetics of release and solubilization, with the highest BAC after duodenal digestion...
October 12, 2016: Food & Function
Rohit Bisht, Bhuwan Chandra Joshi, Ajudhiya Nath Kalia, Atish Prakash
Parkinson's disease (PD) having a complex and multi-factorial neuropathology includes mainly the degeneration of the dopaminergic nigrostriatal pathway, which is a cumulative effect of depleted endogenous antioxidant enzymes, increased oxidative DNA damage, mitochondrial dysfunction, excitotoxicity, and neuroinflammation. The present study was designed to investigate the neuroprotective effect of a potent antioxidant from Urtica dioica in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model of parkinsonism...
September 13, 2016: Molecular Neurobiology
Rahila Qayyum, Hafiz Misbah-Ud-Din Qamar, Shamim Khan, Umme Salma, Taous Khan, Abdul Jabbar Shah
BACKGROUND: Urtica dioica has traditionally been used in the management of cardiovascular disorders especially hypertension. The aim of this study was to explore pharmacological base of its use in hypertension. METHODS: Crude methanolic extract of U. dioica (Ud.Cr) and its fractions (Ud.EtAc, Ud.nHex, Ud.Chl and Ud.Aq) were tested in vivo on normotensive and hypertensive rats under anesthesia for blood pressure lowering effect. In-vitro experiments on rat and rabbit aortae were employed to probe the vasorelaxation mechanism(s)...
2016: Journal of Translational Medicine
Parvaneh Daneshmand, Kioomars Saliminejad, Marzieh Dehghan Shasaltaneh, Koorosh Kamali, Gholam Hossein Riazi, Reza Nazari, Pedram Azimzadeh, Hamid Reza Khorram Khorshid
BACKGROUND: Sporadic Alzheimer's Disease (SAD) is caused by genetic risk factors, aging and oxidative stresses. The herbal extract of Rosa canina (R. canina), Tanacetum vulgare (T. vulgare) and Urtica dioica (U. dioica) has a beneficial role in aging, as an anti-inflammatory and anti-oxidative agent. In this study, the neuroprotective effects of this herbal extract in the rat model of SAD was investigated. METHODS: The rats were divided into control, sham, model, herbal extract -treated and ethanol-treated groups...
July 2016: Avicenna Journal of Medical Biotechnology
Jafar Abolghasemi
BACKGROUND: According to traditional Persian medicine (TPM) resources, the human digestive system includes four steps. In the first step, gastric digestion, the ingested food pours into the stomach and changes into the leachate called chylous due to the heat produced in the stomach. In the second step, hepatic digestion, the chylous enters in the liver through mesenteric vessels and transforms into the quadruple humors, sanguine, phlegm, bile and black bile due to the liver heat. In the case of humor predominance, using moshel or cathartic medicines is considered as a strategic medical plan...
May 2016: Iranian Journal of Medical Sciences
İbrahim Kaya, Deniz Gülabi, Murat Yilmaz, Ali Baş, Gültekin Sıtkı Çeçen Çeçen, Nurullah Şener
BACKGROUND/AIM: Ankaferd blood stopper (ABS) is a mixture of certain ratios of 5 different plant roots (Thymus vulgaris, Glycyrrhiza glabra, Vitis vinifera, Alpinia officinarum, and Urtica dioica). The aim of this study is to evaluate the histopathological effects of ABS on articular cartilage in vitro. MATERIALS AND METHODS: Twenty-one albino Sprague Dawley rats were randomly allocated to 3 groups: 0.1 mL of saline was injected in the first group, 0.1 mL of ABS was injected in the second group, and 0...
2016: Turkish Journal of Medical Sciences
Ali Mohammadi, Behzad Mansoori, Mahyar Aghapour, Solmaz Shirjang, Sanam Nami, Behzad Baradaran
INTRODUCTION: Due to the chemo resistant nature of cancer cells and adverse effects of current therapies, researchers are looking for the most efficient therapeutic approach which has the lowest side effects and the highest toxicity on cancer cells. The aim of the present study was to investigate the synergic effect of Urtica dioica extract in combination with paclitaxel on cell death and invasion of human breast cancer MDA-MB-468 cell line. MATERIALS AND METHODS: To determine the cytotoxic effects of Urtica dioica extract with paclitaxel, MTT assay was performed...
August 5, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Sita Sharan Patel, Neeraj Mahindroo, Malairaman Udayabanu
The present study was aimed to evaluate the effect of Urtica dioica (UD) extract against chronic unpredictable stress (CUS)-induced associative memory dysfunction and attempted to explore the possible mechanism. Male Swiss albino mice (25-30g) were divided into six groups, viz. group-I received 0.3% carboxymethyl cellulose and served as control (CTRL), group II was exposed to CUS (21days) and received vehicle (CUS), group III was subjected to CUS and received Hypericum perforatum extract (350mg/kg, p.o.) (CUS+HYP), group IV received Hypericum perforatum extract (350mg/kg, p...
July 28, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Sara Haghju, Sara Beigzadeh, Hadi Almasi, Hamed Hamishehkar
The objective of this study was to characterise and compare physical, mechanical and antimicrobial properties of chitosan-based films, containing free or nanoencapsulated nettle (Urtica dioica L.) extract (NE) at concentrations of 0, 0.5, 1 and 1.5% w/w. Nanoliposomes were prepared using soy-lecithin by thin-film hydration and sonication method to generate an average size of 107-136 nm with 70% encapsulation efficiency. The information on FT-IR reflected that some new interaction have occurred between chitosan and nanoliposomes...
July 17, 2016: Journal of Microencapsulation
Hadi Almasi, Mohsen Zandi, Sara Beigzadeh, Sara Haghju, Nazila Mehrnow
Chitosan films were loaded with NE nettle (Urtica dioica L.) extract (NE) at concentrations of 0, 0.5, 1 and 1.5%w/w in the free or nanoliposomal form to obtain active and nanoactive films, respectively. The antioxidant potential of the films containing NE-loaded nanoliposomes was decreased in comparison of free NE incorporated films. Diffusion of NE to soybean oil was enough to delay the induction of the oxidation of soybean oil stored for 60 days in contact with chitosan based films. Release studies indicated that the release rate of NE in 95% ethanol simulant significantly decreased by the nanoencapsulation of NE...
July 14, 2016: Journal of Microencapsulation
Sárka Moravcová, Vendula Fiedlerová, Jirí Tůma, Karel Musil, Lenka Tůmová
The effect of four pyrazine derivatives on the content of phenolic compounds in Urtica dioica L. and rutin in Fagopyrum esculentum Moench was studied. Pyrazine derivatives H1 and H2 were used on U. dioica, and derivatives S1 and S2 on F. esculentum, both separately and in combination with urea. The content of phenolic compounds in the stems of U. dioica after treatment with H2 at a concentration of 10(-3) M significantly increased compared with the control and to a lower concentration of the same pyrazine derivative...
April 2016: Natural Product Communications
C Aktas, M Erboga, Z Fidanol Erboga, Y Bozdemir Donmez, B Topcu, A Gurel
In this study, it was aimed to examine the effects of Urtica dioica L. (UD) that has antioxidant feature in the experimental testicular I/R model in rats in terms of anti-apoptotic and antioxidative effects. In our study, 24 male rats were divided into three groups: control group, I/R group and I/R + UD (2 mg kg(-1) ) group. Seminiferous tubule calibre measurement, Johnson score, haematoxylin-eosin staining, proliferative cell nucleus antigen (PCNA) immunohistochemical staining and TUNEL as histopathological have been conducted...
July 8, 2016: Andrologia
Zbigniew Zając, Bartosik Katarzyna, Alicja Buczek
INTRODUCTION AND OBJECTIVES: Despite the increasing prevalence and significant role of D. reticulatus in pathogen transmission, the factors influencing its distribution and activity are still poorly known. The paper presents for the first time a study of the D. reticulatus ecology in a protected area, in which the dependence of D. reticulatus occurrence and activity on the ecological habitat type is analysed. MATERIALS AND METHODS: Tick collection and environmental monitoring were conducted from March - November 2012 and 2014 in five ecologically-diverse habitats in the Polesie National Park of central-eastern Poland...
June 2, 2016: Annals of Agricultural and Environmental Medicine: AAEM
Celal Irgin, Bayram Çörekçi, Fatih Ozan, Koray Halicioğlu, Orçun Toptaş, Arzu Birinci Yildirim, Arzu Türker, Fahri Yilmaz
OBJECTIVE: To determine whether systemically given stinging nettle (SN) has an effect on bone formation in response to expansion of the rat inter-premaxillary suture. MATERIALS AND METHODS: A total of 28 male Wistar albino rats were randomly divided into 4 equal groups: control (C), only expansion (OE), SN extract given only during the expansion and retention periods (SN group; a total of 17days), and SN extract given during the nursery phase before expansion (a period of 40days) and during the expansion and retention periods (N+SN group; a total of 57days)...
September 2016: Archives of Oral Biology
M Movassaghi, S Hassannejad
Eastern dodder (Cuscuta monogyna Vahl.) is one of the noxious parasitic weeds that infected many ornamental trees in green spaces and gardens. Our purpose is to find natural inhibitors for prevention of its seed germination. In order to reach this aim, laboratory studies were conducted by using of herbaceous distillates of Dracocephalum moldavica, Nasturtium officinalis, Malva neglecta, Mentha piperita, Mentha pulegium, Rosa damascene, Ziziphora tenuior, and Urtica dioica on seed germination of C. monogyna...
2015: Communications in Agricultural and Applied Biological Sciences
Karolina Jakubczyk, Katarzyna Janda, Sylwia Szkyrpan, Izabela Gutowska, Jolanta Wolska
Stinging nettle (Urtica dioica L.) belongs to the family Urticaceae. It grows in the wild form in Asia, Europe, North America and North Africa. Stinging nettle is also a widespread ruderal plant found in Poland. Urtica dioica L., as a plant rich in biologically active compounds, is considered one of the most important plants used in phytotherapy. In vitro and in vivo studies have demonstrated its antioxidant, antiplatelet, hypoglycaemic and hypocholesterolemic properties. Research conducted in recent years indicates the possibility of using nettle in chemoprevention, diabetes, benign prostatic hyperplasia and urologic diseases...
2015: Pomeranian Journal of Life Sciences
Grzegorz Olszewski, Alicja Boryło, Bogdan Skwarzec
The aim of this study was to determine uranium concentrations in common nettle (Urtica dioica) plants and corresponding soils samples which were collected from the area of phosphogypsum stockpile in Wiślinka (northern Poland). The uranium concentrations in roots depended on its concentrations in soils. Calculated BCF and TF values showed that soils characteristics and air deposition affect uranium absorption and that different uranium species have different affinities to U. dioica plants. The values of (234)U/(238)U activity ratio indicate natural origin of these radioisotopes in analyzed plants...
2016: Journal of Radioanalytical and Nuclear Chemistry
A Mohammadi, B Mansoori, M Aghapour, B Baradaran
Prostate cancer is considered as the major cause of death among men around the world. There are a number of medicinal plants triggering apoptosis response in cancer cells, thus have a therapeutic potential. Therefore, further studies to characterize beneficial properties of these plants in order to introduce novel anti-cancer drugs are the interest of recent researches on the alternative medicine. On the other hand, due to traditional uses and availability of Urtica dioica extract, we decided to evaluate the efficacy of this medicinal herb on pc3 prostate cancer cell line...
2016: Cellular and Molecular Biology
Wafa Siouda, Cherif Abdennour
AIM: The objective of this study was to investigate the possible protective role of nettle Urtica dioica (UD) against Hg-induced toxicity. MATERIALS AND METHODS: A total of 28 rats were equally divided into four groups: the control, the Hg (0.8 g HgCl2/kg in the diet), the UD (1.5 ml UD/rat by gavage), and the Hg+UD group. HgCl2 was daily dissolved in distilled water and immediately mixed with the standard diet. A solution of daily infused fresh nettle leaves in boiling water (16 g in 25 ml) was obtained and then it was administrated by gavage...
December 2015: Veterinary World
Abbas Ranjbari, Mohammad Ali Azarbayjani, Ashril Yusof, Abdul Halim Mokhtar, Samad Akbarzadeh, Mohamed Yousif Ibrahim, Bahman Tarverdizadeh, Parviz Farzadinia, Reza Hajiaghaee, Firouzeh Dehghan
BACKGROUND: Urtica dioica (UD) has been identified as a traditional herbal medicine. This study aimed to investigate the effect of UD extract and swimming activity on diabetic parameters through in vivo and in vitro experiments. METHODS: Adult WKY male rats were randomly distributed in nine groups: intact control, diabetic control, diabetic + 625 mg/kg, 1.25 g/kg UD, diabetic + 100 mg/kg Metformin, diabetic + swimming, diabetic + swimming 625 mg/kg, 1.25 g/kg UD, and diabetic +100 mg/kg Metformin + swimming...
2016: BMC Complementary and Alternative Medicine
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