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Hannah A Blair
No abstract text is available yet for this article.
April 2022: Drugs & Aging
#22
JOURNAL ARTICLE
L G Luciani, D Mattevi, V Vattovani, T Cai, G Giusti, G Malossini
INTRODUCTION AND OBJECTIVES: Our objective is to assess the long-term results of phytotherapy, focusing on the interval between phytotherapy and pharmacological treatment and the predisposing risk factors to such switch on a 10-year follow-up. MATERIAL AND METHODS: The data of patients taking phytotherapy for mild to moderate male lower urinary tract symptoms (LUTS) from January to December 2010 were retrospectively reviewed from a prospectively maintained database...
March 22, 2022: Actas urologicas españolas
#23
JOURNAL ARTICLE
Gianni Paulis, Andrea Paulis, Gianpaolo Perletti
BACKGROUND: Serenoa repens (SR) is a plant used to treat benign prostatic hyperplasia and prostatitis. We know that SR act as a 5α-reductase inhibitor, moreover, several studies have proved that SR has anti-inflammatory and antioxidant properties. There is some belief among patients that SR may negatively impact male sexual function. Such belief is circulating in non-medical social networks and is perhaps maintained by patients as a result of incorrect web surfing. However, it is also possible that SR may exert a "nocebo" effect thus negatively impacting on the general well-being of patients...
December 21, 2021: Archivio Italiano di Urologia, Andrologia
#24
COMPARATIVE STUDY
Antonio Alcaraz, Alfredo Rodríguez-Antolín, Joaquín Carballido-Rodríguez, David Castro-Díaz, José Medina-Polo, Jesús M Fernández-Gómez, Vincenzo Ficarra, Joan Palou, Javier Ponce de León Roca, Javier C Angulo, Manuel Esteban-Fuertes, José M Cózar-Olmo, Noemí Pérez-León, José M Molero-García, Antonio Fernández-Pro Ledesma, Francisco J Brenes-Bermúdez, José Manasanch
In a subset analysis of data from a 6-month, multicenter, non-interventional study, we compared change in symptoms and quality of life (QoL), and treatment tolerability, in men with moderate to severe lower urinary tract symptoms associated with benign prostatic hyperplasia (LUTS/BPH) receiving tamsulosin (TAM, 0.4 mg/day) or the hexanic extract of Serenoa repens (HESr, 320 mg/day) as monotherapy. Symptoms and QoL were assessed using the IPSS and BII questionnaires, respectively. Patients in the treatment groups were matched using two statistical approaches (iterative and propensity score matching)...
September 29, 2021: Scientific Reports
#25
JOURNAL ARTICLE
Leonel Fabrizio Trivisonno, Nadia Sgarbossa, Gustavo Ariel Alvez, Cecilia Fieiras, Camila Micaela Escobar Liquitay, Jae Hung Jung, Juan Víctor Ariel Franco
PURPOSE: To assess the effects of Serenoa repens alone or in combination with other phytotherapy compared to placebo in men with LUTS due to benign prostatic enlargement. MATERIALS AND METHODS: Following a registered protocol (CRD42021226655), we searched (December 2020) MEDLINE, CENTRAL, Embase, ClinicalTrials.gov, WHO-ICTRP trials platform and other sources with no restrictions on language, publication date or status. We included randomized controlled trials, and we critically appraised them using the Cochrane Tool for Risk of Bias Assessment (RoB 2)...
September 2021: Investigative and Clinical Urology
#26
JOURNAL ARTICLE
Igor Gorpynchenko, Kamil Nurimanov, Tatiana Poroshina, Viktoria Savchenko, George Drannik, Alexander Shulyak
Introduction: We hypothesized that the history of antibiotic efficacy was related to the outcome of the treatment of patients with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) and evaluated this as a phenotyping factor for such patients. Material and methods: This prospective study included 74 patients with CP/CPPS aged 18-45 years old, who had at least 10 points on the National Institutes of Health-Chronic Prostatitis Symptom Index (NIH-CPSI) scale and did not receive treatment for CP/CPPS for the last 3 months...
2021: Central European Journal of Urology
#27
JOURNAL ARTICLE
A V Sivkov, V I Kirpatovskyi
Based on literature data, feasibility of combined therapy with Serenoa repens extracts (including Permixon) and 1-adrenoblocators in patients with LUTS/BPH based on the pathogenesis of these drugs and clinical results was analyzed. The composition and biological activity of various SRE is influenced by the extraction method, as well as the production technology used by the manufacturer, which can lead to different results of experimental and clinical studies. The mechanism of action of SRE, including hexane extract Permixon, is multicomponent, which combines an antiandrogenic effect, influence on neurogenic regulation of urinary tract function (-adrenoreceptors, M-holinoreceptors, vanilloid receptors), anti-inflammatory and anti-edematous actions...
March 2021: Urologii︠a︡
#28
JOURNAL ARTICLE
Angela Assunta Lopedota, Ilaria Arduino, Antonio Lopalco, Rosa Maria Iacobazzi, Annalisa Cutrignelli, Valentino Laquintana, Giuseppe Racaniello, Massimo Franco, Flavia la Forgia, Sergio Fontana, Nunzio Denora
Natural oils that are rich in biologically active polyunsaturated fatty acids have many health benefits but have insufficient bioavailability and may oxidize in the gastrointestinal tract. For these reasons and to improve the handling as well, the possibility of incorporating a natural oil, extracted from Serenoa Repens fruits (SR-oil), in alginate-based beads was investigated. SR-oil has been used from centuries in both traditional and modern medicine for various nutraceutical or therapeutic purposes such as, in both sexes, as a general tonic, for genitourinary problems, to increase sexual vigor, as a diuretic or to treat in male lower urinary tract symptoms and benign prostatic hyperplasia...
March 1, 2021: International Journal of Pharmaceutics
#29
JOURNAL ARTICLE
Giulia Vanti, Maria Camilla Bergonzi, Anna Rita Bilia
Liposomes represent, among the nanocarriers, the most useful ones for dermatological use, and their composition, charge, size strongly influence their performance in topical drug delivery systems, with possible accumulation of the loaded drugs in the hair follicles. Recently, a saw palmetto carbon dioxide (CO₂) extract has been reported useful for the treatment of hair loss because of the inhibition of 5 α -reductase enzyme, responsible of the conversion of testosterone to the most potent androgen, the 5 α -dihydrotestosterone...
May 1, 2021: Journal of Nanoscience and Nanotechnology
#30
RANDOMIZED CONTROLLED TRIAL
Kai Zhang, Run-Qi Guo, Shan-Wen Chen, Bin Chen, Xin-Bo Xue, Shan Chen, Jian Huang, Ming Liu, Ye Tian, Li Zuo, Ming Chen, Li-Qun Zhou
PURPOSE: To perform a placebo-controlled trial to evaluate the efficacy and safety of Serenoa repens extract (SRE) for the treatment of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). METHODS: We conducted a double-blind, randomized, placebo-controlled, multicenter, clinical phase 4 study of 221 patients with CP/CPPS across 11 centers. Participants were randomly assigned in a 2:1 ratio to receive SRE or placebo for 12 weeks. The primary efficacy endpoint was the change in total score on the National Institutes of Health-Chronic Prostatitis Symptom Index (NIH-CPSI)...
September 2021: World Journal of Urology
#31
JOURNAL ARTICLE
Miriam Saponaro, Isabella Giacomini, Giulia Morandin, Veronica Cocetta, Eugenio Ragazzi, Genny Orso, Ilaria Carnevali, Massimiliano Berretta, Mariangela Mancini, Francesco Pagano, Monica Montopoli
Benign prostatic hyperplasia (BPH) is an age-related chronic disorder, characterized by the hyperproliferation of prostatic epithelial and stromal cells, which drives prostate enlargement. Since BPH aetiology and progression have been associated with the persistence of an inflammatory stimulus, induced both by Nuclear Factor-kappa B (NF-κB) activation and reactive oxygen species (ROS) production, the inhibition of these pathways could result in a good tool for its clinical treatment. This study aimed to evaluate the antioxidant and anti-inflammatory activity of a combined formulation of Serenoa repens and Urtica dioica (SR/UD) in an in vitro human model of BPH...
December 2, 2020: International Journal of Molecular Sciences
#32
JOURNAL ARTICLE
P W Crous, M J Wingfield, Y-H Chooi, C L M Gilchrist, E Lacey, J I Pitt, F Roets, W J Swart, J F Cano-Lira, N Valenzuela-Lopez, V Hubka, R G Shivas, A M Stchigel, D G Holdom, Ž Jurjević, A V Kachalkin, T Lebel, C Lock, M P Martín, Y P Tan, M A Tomashevskaya, J S Vitelli, I G Baseia, V K Bhatt, T E Brandrud, J T De Souza, B Dima, H J Lacey, L Lombard, P R Johnston, A Morte, V Papp, A Rodríguez, E Rodríguez-Andrade, K C Semwal, L Tegart, Z G Abad, A Akulov, P Alvarado, A Alves, J P Andrade, F Arenas, C Asenjo, J Ballarà, M D Barrett, L M Berná, A Berraf-Tebbal, M V Bianchinotti, K Bransgrove, T I Burgess, F S Carmo, R Chávez, A Čmoková, J D W Dearnaley, A L C M de A Santiago, J F Freitas-Neto, S Denman, B Douglas, F Dovana, A Eichmeier, F Esteve-Raventós, A Farid, A G Fedosova, G Ferisin, R J Ferreira, A Ferrer, C N Figueiredo, Y F Figueiredo, C G Reinoso-Fuentealba, I Garrido-Benavent, C F Cañete-Gibas, C Gil-Durán, A M Glushakova, M F M Gonçalves, M González, M Gorczak, C Gorton, F E Guard, A L Guarnizo, J Guarro, M Gutiérrez, P Hamal, L T Hien, A D Hocking, J Houbraken, G C Hunter, C A Inácio, M Jourdan, V I Kapitonov, L Kelly, T N Khanh, K Kisło, L Kiss, A Kiyashko, M Kolařík, J Kruse, A Kubátová, V Kučera, I Kučerová, I Kušan, H B Lee, G Levicán, A Lewis, N V Liem, K Liimatainen, H J Lim, M N Lyons, J G Maciá-Vicente, V Magaña-Dueñas, R Mahiques, E F Malysheva, P A S Marbach, P Marinho, N Matočec, A R McTaggart, A Mešić, L Morin, J M Muñoz-Mohedano, A Navarro-Ródenas, C P Nicolli, R L Oliveira, E Otsing, C L Ovrebo, T A Pankratov, A Paños, A Paz-Conde, A Pérez-Sierra, C Phosri, Á Pintos, A Pošta, S Prencipe, E Rubio, A Saitta, L S Sales, L Sanhueza, L A Shuttleworth, J Smith, M E Smith, D Spadaro, M Spetik, M Sochor, Z Sochorová, J O Sousa, N Suwannasai, L Tedersoo, H M Thanh, L D Thao, Z Tkalčec, N Vaghefi, A S Venzhik, A Verbeken, A Vizzini, S Voyron, M Wainhouse, A J S Whalley, M Wrzosek, M Zapata, I Zeil-Rolfe, J Z Groenewald
Novel species of fungi described in this study include those from various countries as follows: Antarctica , Cladosporium arenosum from marine sediment sand. Argentina , Kosmimatamyces alatophylus (incl. Kosmimatamyces gen. nov.) from soil. Australia , Aspergillus banksianus , Aspergillus kumbius , Aspergillus luteorubrus , Aspergillus malvicolor and Aspergillus nanangensis from soil, Erysiphe medicaginis from leaves of Medicago polymorpha , Hymenotorrendiella communis on leaf litter of Eucalyptus bicostata , Lactifluus albopicri and Lactifluus austropiperatus on soil, Macalpinomyces collinsiae on Eriachne benthamii , Marasmius vagus on soil, Microdochium dawsoniorum from leaves of Sporobolus natalensis , Neopestalotiopsis nebuloides from leaves of Sporobolus elongatus , Pestalotiopsis etonensis from leaves of Sporobolus jacquemontii , Phytophthora personensis from soil associated with dying Grevillea mccutcheonii...
June 2020: Persoonia
#33
JOURNAL ARTICLE
Christopher J Butler, Matt Larson
Palms (Arecaceae) are a relatively speciose family and provide materials for food, construction, and handicraft, especially in the tropics. They are frequently used as paleo-indicators for megathermal climates, and therefore, it is logical to predict that palms will benefit from predicted warmer temperatures under anthropogenic climate change. We created species distribution models to explore the projected ranges of five widespread southeastern North American palm species ( Rhapidophyllum hystrix , Sabal etonia , Sabal minor , Sabal palmetto , and Serenoa repens ) under four climate change scenarios through 2070...
October 2020: Ecology and Evolution
#34
JOURNAL ARTICLE
Antonio Alcaraz, Alfredo Rodríguez-Antolín, Joaquín Carballido-Rodríguez, David Castro-Díaz, Manuel Esteban-Fuertes, José M Cózar-Olmo, Vincenzo Ficarra, Rafael Medina-López, Jesús M Fernández-Gómez, Javier C Angulo, José Medina-Polo, Francisco J Brenes-Bermúdez, José M Molero-García, Antonio Fernández-Pro-Ledesma, José Manasanch, On Behalf Of The Qualiprost Study Group
To investigate whether tamsulosin (TAM) and the hexanic extract of Serenoa repens (HESr) are more effective in combination than as monotherapy in men with moderate-to-severe lower urinary tract symptoms associated with benign prostatic hyperplasia (LUTS/BPH). Subset analysis of data from a 6-month, multicenter observational study. Patients received either tamsulosin (0.4 mg/day) or HESr (320 mg/day) alone or in combination. Primary endpoints were change in symptoms and quality of life. Tolerability was also assessed...
September 9, 2020: Journal of Clinical Medicine
#35
JOURNAL ARTICLE
P W Crous, M J Wingfield, R K Schumacher, A Akulov, T S Bulgakov, A J Carnegie, Ž Jurjević, C Decock, S Denman, L Lombard, D P Lawrence, A J Stack, T R Gordon, R M Bostock, T Burgess, B A Summerell, P W J Taylor, J Edwards, L W Hou, L Cai, A Y Rossman, T Wöhner, W C Allen, L A Castlebury, C M Visagie, J Z Groenewald
Seven new genera, 26 new species, 10 new combinations, two epitypes, one new name, and 20 interesting new host and / or geographical records are introduced in this study. New genera are: Italiofungus (based on Italiofungus phillyreae ) on leaves of Phillyrea latifolia (Italy); Neolamproconium (based on Neolamproconium silvestre ) on branch of Tilia sp. (Ukraine); Neosorocybe (based on Neosorocybe pini ) on trunk of Pinus sylvestris (Ukraine); Nothoseptoria (based on Nothoseptoria caraganae ) on leaves of Caragana arborescens (Russia); Pruniphilomyces (based on Pruniphilomyces circumscissus ) on Prunus cerasus (Russia); Vesiculozygosporium (based on Vesiculozygosporium echinosporum ) on leaves of Muntingia calabura (Malaysia); Longiseptatispora (based on Longiseptatispora curvata ) on leaves of Lonicera tatarica (Russia)...
December 2020: Fungal systematics and evolution
#36
JOURNAL ARTICLE
Carolyn J Hanish, Sebastian Velez, Jon A Moore, Corey Devin Anderson
Some large-seeded plants lack effective seed dispersal agents when they are introduced as ornamental plants to new areas, but can rapidly colonize a landscape if seed dispersal functions are restored. We examined whether Gopherus polyphemus (Gopher Tortoise) facilitated the spread of Chrysobalanus icaco (Cocoplum; Chrysobalanaceae) over a 14-year period in a suburban nature preserve (in Jupiter, FL, USA) by: (i) comparing germination patterns among gut-passed, hand-depulped and whole fruit treatments, and (ii) testing hypotheses about environmental predictors of the spatial distribution of C...
August 2020: AoB Plants
#37
JOURNAL ARTICLE
Steven A Kaplan
No abstract text is available yet for this article.
June 18, 2020: Journal of Urology
#38
JOURNAL ARTICLE
Tong Cai, Yuanshan Cui, Shaoxia Yu, Qian Li, Zhongbao Zhou, Zhenli Gao
Studies reported that Serenoa repens was effective in relieving lower urinary tract symptoms (LUTS). This article carried out a systematic review and meta-analysis to compare Serenoa repens with tamsulosin in the treatment of benign prostatic hyperplasia (BPH) after at least 6-month treatment cycle. Four studies involving 1,080 patients (543 in the Serenoa repens group and 537 in the tamsulosin group) were included in the meta-analysis. The results were as follows: compared with tamsulosin, Serenoa repens had a same effect in treating BPH in terms of International Prostate Symptom Score (IPSS) (mean difference [MD] 0...
March 2020: American Journal of Men's Health
#39
JOURNAL ARTICLE
Michael Samarinas, Anastasios Karatzas, Vasileios Tzortzis, Stavros Gravas
A randomized biopsy study showed that hexanic Serenoa repens (HESr) treatment resulted in prostatic inflammation reduction. This post-hoc analysis evaluated the clinical impact of HESr and investigated correlations between baseline parameters and treatment response. Patients were randomized to receive HESr 320mg/day for six months or no therapy. Assessment included International Prostate Symptoms Score (IPSS), prostate volume (PV), and maximum flow rate (Qmax). Baseline characteristics were recorded, including body mass index (BMI) and metabolic syndrome (MetS) components...
March 30, 2020: Journal of Clinical Medicine
#40
JOURNAL ARTICLE
Huan-Tao Zong, Xiao-Yan Wang, Tao Wang, Xin Zhou, Yong Zhang
OBJECTIVE: To evaluate the effect and safety of Serenoa repens extract (SR) combined with α-receptor blocker (αRB) in the treatment of BPH. METHODS: We included 7 published randomized controlled trials (RCT) studying the effect and safety of SR+αRB versus αRB monotherapy in the treatment of 1 009 BPH patients, and performed a meta-analysis on the data obtained using the RevMan 5.1.3 software. RESULTS: The baseline data from the RCTs were all comparable...
June 2019: Zhonghua Nan Ke Xue, National Journal of Andrology
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