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Serenoa repens

Bruno Giammusso, Rosaria Di Mauro, Renato Bernardini
BACKGROUND: Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a complex condition, characterized by uncertain etiology and by limited response to therapy. The definition of CP/CPPS includes genitourinary pain with or without voiding symptoms in the absence of uropathogenic bacteria, as detected by standard microbiological methods, or another identifiable cause such as malignancy. The efficacy of various medical therapies, has been evaluated in clinical studies, but evidence is lacking or conflicting...
March 31, 2017: Archivio Italiano di Urologia, Andrologia
Giuseppe Morgia, Antonio Micali, Mariagrazia Rinaldi, Natasha Irrera, Herbert Marini, Domenico Puzzolo, Antonina Pisani, Salvatore Privitera, Giorgio I Russo, Sebastiano Cimino, Antonio Ieni, Vincenzo Trichilo, Domenica Altavilla, Francesco Squadrito, Letteria Minutoli
Benign prostatic hyperplasia (BPH) treatment includes the apoptosis machinery modulation through the direct inhibition of caspase cascade. We previously demonstrated that Serenoa repens (Ser) with lycopene (Ly) and selenium (Se) reawakened apoptosis by reducing survivin and neuronal apoptosis inhibitory protein (NAIP) levels in rats. The aim of this study was to evaluate the effectiveness of Ser-Se-Ly association on survivin and NAIP expression in BPH patients. Ninety patients with lower urinary tract symptoms (LUTS) due to clinical BPH were included in this randomized, double-blind, placebo-controlled trial...
March 22, 2017: International Journal of Molecular Sciences
Josué V Espinosa-Juárez, Juventino Iii Colado-Velázquez, Patrick Mailloux-Salinas, Jml Medina-Contreras, P Valentín Correa-López, N L Gómez-Viquez, Fabián Meza-Cuenca, Fengyang Huang, Guadalupe Bravo
BACKGROUND: Obesity is associated with an increased risk of a number of serious medical conditions, including urological disorders. This study investigated the effect of lipidic extract of Saladette Tomato Pomace (STP) and Serenoa repens (SR) on prostate and bladder in a rat obese model induced by high-carbohydrates diet. RESULTS: High-sucrose fed rats showed higher weight of prostate, increased contractility, stromal and epithelial hyperplasia in prostate. The treatment with STP and SR improved contractility, diminished hyperplasia and hypertrophy in prostate in obesity model...
March 8, 2017: Journal of the Science of Food and Agriculture
Paolo Governa, Daniela Giachetti, Marco Biagi, Fabrizio Manetti, Luca De Vico
Benign prostatic hyperplasia is a common disease in men aged over 50 years old, with an incidence increasing to more than 80% over the age of 70, that is increasingly going to attract pharmaceutical interest. Within conventional therapies, such as α-adrenoreceptor antagonists and 5α-reductase inhibitor, there is a large requirement for treatments with less adverse events on, e.g., blood pressure and sexual function: phytotherapy may be the right way to fill this need. Serenoa repens standardized extract has been widely studied and its ability to reduce lower urinary tract symptoms related to benign prostatic hyperplasia is comprehensively described in literature...
2016: PeerJ
Rainer C Görne, Tankred Wegener, Olaf Kelber, Björn Feistel, Jürgen Reichling
In this review, results of randomized double-blind controlled clinical trials (RCTs) with extracts of Serenoa repens fruits at a dose of 320 mg/d for the treatment of lower urinary tract symptoms (LUTS) are assessed. Of the RTCs conducted for up to 6 months, a benefit was seen in three of three RTCs with ethanolic, in eight of nine RTCs with hexane, and in one of two RTCs with CO2 extracts. Of the RTCs conducted for more than 6 months, a benefit was seen in two RTCs with hexane and in one RTC with CO2 extracts, whereas one RTC with an ethanolic, two RTCs with hexane, and one RTC with CO2 extracts did not show positive results...
November 29, 2016: Wiener Medizinische Wochenschrift
Serena Stigliano, Livia Archibugi, Giulia Zerboni, Gianfranco Delle Fave, Gabriele Capurso
BACKGROUND: Herbal remedies and other complementary and alternative medicine (CAM) are used by 30% of the patients with liver and inflammatory bowel diseases. However, there are no data regarding CAM use in patients with pancreatic disorders, including potential pancreatotoxicity. AIM OF THE STUDY: The aim of the study was to assess the prevalence of CAM use in patients with pancreatic disorders and screen for pancreatotoxicity. MATERIALS AND METHODS: This was a cross-sectional survey of consecutive outpatients seen at a Pancreas Center...
November 2016: Journal of Clinical Gastroenterology
Tommaso Cai, Daniele Tiscione, Luca Gallelli, Paolo Verze, Alessandro Palmieri, Vincenzo Mirone, Riccardo Bartoletti, Gianni Malossini
OBJECTIVE: To date, the management of patients with chronic bacterial prostatitis (CBP) is not satisfactory, especially in terms of symptoms relief. Here, we evaluated the efficacy and the safety of a combination of serenoa repens, selenium and lycopene extract + bromelain and methylsulfonylmethane extract associated with levofloxacin in patients with CBP. MATERIALS AND METHODS: All patients with clinical and instrumental diagnosis of CBP, admitted to a single Urological Institution from March to June 2015 were enrolled in this phase III study...
October 5, 2016: Archivio Italiano di Urologia, Andrologia
Giuseppe Quarto, Arturo Cola, Sisto Perdonà
BACKGROUND: The relationship between lower urinary tract symptoms (LUTS) and erectile dysfunction (ED) has received increased attention recently. This study aims to evaluate the efficacy of IDIProst® Gold, a product containing Serenoa repens, Crocus sativus and PMBE (Pinus massoniana bark extract), in improving sexual function, urinary symptoms and quality of life in patients with concomitant LUTS and ED. METHODS: 140 men (mean age 48 years) were enrolled and treated in this study...
September 1, 2016: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
Giorgio Bozzini, Marco Provenzano, Nicolò Buffi, Mauro Seveso, Giovanni Lughezzani, Giorgio Guazzoni, Alberto Mandressi, Gianluigi Taverna
BACKGROUND: Nonbacterial prostatitis, together with chronic pelvic pain syndrome, accounts for 90-95 % of prostatitis cases. Anti-inflammatory medications are commonly used to reduce storage/inflammatory symptoms that can deteriorate quality of life. The purpose of this study was to observe the efficacy and safety of beclomethasone dipropionate rectal suppositories (Topster®) in inflammations of the lower urinary tract in men. METHODS: Patients underwent diagnostic and therapeutic protocols according to current evidence-based practice...
June 8, 2016: BMC Urology
Andrea Russo, Paolo Capogrosso, Giovanni La Croce, Eugenio Ventimiglia, Luca Boeri, Alberto Briganti, Rocco Damiano, Francesco Montorsi, Andrea Salonia
Benign prostatic hyperplasia (BPH) is a disease affecting most of the elderly male. α1-blockers and 5-alpha reductase inhibitors are currently used to target lower urinary tract symptoms (LUTS). Moreover phytotherapeutic agents, including Serenoa Repens (SeR), have shown to have a role in ameliorating BPH/LUTS alone or in combination of other elements like Selenium (Se) and Lycopene (Ly). Areas covered: A literature review was performed using data from articles assessing the role of of SeR+Se+Ly in the management of LUTS secondary to BPH...
December 2016: Expert Opinion on Drug Safety
Luigi Gallo
OBJECTIVE: To investigate the effectiveness and the tolerability of a combined pure anti-inflammatory therapy not associated with antibiotics on reducing PSA levels. MATERIALS AND METHODS: Patients with a previous biopsy negative for prostate cancer and showing persisting level of prostate-specific antigen (PSA) greater than 4 ng/dl were recruited. The specimens of previous biopsy were classified as benign or showing inflammation. Eligible patients were divided into 2 equal groups...
August 2016: Urology
Fabrizio Iacono, Domenico Prezioso, Ester Illiano, Antonio Ruffo, Giuseppe Romeo, Bruno Amato
No abstract text is available yet for this article.
2016: BMC Surgery
Gwen K Wyatt, Alla Sikorskii, Abolfazl Safikhani, Kevin T McVary, James Herman
CONTEXT: Lower urinary tract symptoms (LUTSs) affect 75%-80% of men undergoing radiation therapy (RT) for prostate cancer. OBJECTIVES: To determine the safety, maximum tolerated dose (MTD), and preliminary efficacy of Serenoa repens commonly known as saw palmetto (SP) for management of LUTS during RT for prostate cancer. METHODS: The dose finding phase used the time-to-event continual reassessment method to evaluate safety of three doses (320, 640, and 960 mg) of SP...
June 2016: Journal of Pain and Symptom Management
Antonio Alcaraz, Joaquín Carballido-Rodríguez, Miguel Unda-Urzaiz, Rafael Medina-López, José L Ruiz-Cerdá, Federico Rodríguez-Rubio, Darío García-Rojo, Francisco J Brenes-Bermúdez, José M Cózar-Olmo, Víctor Baena-González, José Manasanch
PURPOSE: To evaluate change in quality of life (QoL) and symptoms in patients with lower urinary tract symptoms/benign prostatic hyperplasia (LUTS/BPH) in conditions of current clinical practice. METHODS: Prospective, longitudinal, multicenter open-label study was carried out in urology outpatient clinics. Patients were ≥40 years of age with an International Prostate Symptom Score (IPSS) score ≥ 8. QoL and symptoms were measured at baseline and 6 months using the Benign Prostatic Hyperplasia Impact Index (BII) and the IPSS...
May 2016: International Urology and Nephrology
Mariangela Rondanelli, Simone Perna, Gabriella Peroni, Davide Guido
BACKGROUND: In androgenetic alopecia, a number of botanicals are available that can effectively slow or reduce hair loss and inflammation or stimulate partial hair regrowth. The aim of this study was to provide a descriptive overview of the impact and production of literature on botanicals used for androgenetic alopecia and to perform a citation analysis of the related research articles. METHODS: We searched for "alopecia" OR "androgenetic alopecia" OR "hair loss" AND "Camelia sinensis" OR (and other 15 botanicals) in ARTICLE (Title/Abstract/Keyword) in Scopus database...
June 2016: Journal of Cosmetic Dermatology
Alain Latil, Marie-Thérèse Pétrissans, Jérôme Rouquet, Grégoire Robert, Alexandre de la Taille
BACKGROUND: Chronic prostatic inflammation (CPI) could be a cause of symptomatic or complicated benign prostatic hyperplasia (BPH). In previous in vitro and in vivo studies, Hexanic Extract of Serenoa repens (HESr) namely Permixon(®) has demonstrated potent anti-inflammatory properties. With the aim to provide new insight onto HESr anti-inflammatory properties in human we explore its effect on CPI biomarkers in men with lower urinary tract symptoms (LUTS) related to BPH using a non-invasive method and investigate links between biomarkers and clinical symptoms...
December 2015: Prostate
Juventino Iii Colado-Velázquez, Patrick Mailloux-Salinas, Jml Medina-Contreras, David Cruz-Robles, Guadalupe Bravo
Serenoa repens has been widely used to treat benign prostatic hyperplasia and lower urinary tract symptoms; however, most of the studies have been conducted in individuals with normal weight and not obese. In this study, the effects of a lipidic extract of S. repens, in markers of oxidative stress, inflammation, and growth factors, in obese rats with testosterone-induced prostatic hyperplasia, were investigated. Total nitrites, malondialdehyde, total glutathione, superoxide dismutase (SOD), and catalase activity were measured; in addition, assays for inflammatory cytokines TNF-α, IL-1β, IL-6 and the growth factors basic fibroblast growth factor (FGFb) and vascular endothelial growth factor (VEGF) were performed...
October 2015: Phytotherapy Research: PTR
Paolo Morabito, Marco Miroddi, Salvatore Giovinazzo, Edoardo Spina, Gioacchino Calapai
Serenoa repens, commonly known as saw palmetto, is the sole species currently classified in the genus Serenoa. The plant is a low shrubby palm that is native of West Indies, and it grows in the coastal lands of North America and other European mediterranean countries. Its fruits contain high concentrations of fatty acids and phytosterols. S. repens extracts have been studied for the symptomatic treatment of benign prostatic hyperplasia. Recently, they have been proposed to treat androgenic alopecia and other hair disorders...
2015: Pharmacology
Vesarat Wessagowit, Chinmanat Tangjaturonrusamee, Tanawatt Kootiratrakarn, Thareena Bunnag, Tanatya Pimonrat, Nattaporn Muangdang, Pitchayasak Pichai
BACKGROUND/OBJECTIVES: Male androgenetic alopecia (AGA) is a common hair problem. Serenoa repens extract has been shown to inhibit both types of 5-α reductase and, when taken orally, has been shown to increase hair growth in AGA patients. The aim of this study was to assess the efficacy of topical products containing S. repens extract for the treatment of male AGA. METHODS: This was a pilot, prospective, open, within-subject comparison limited to 24 weeks using no placebo controls...
August 2016: Australasian Journal of Dermatology
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