Ziyu Wei, Meng Gao, Yihe Liu, Rong Zeng, Juan Liu, Shuya Sun, Siyuan Li, Linghan Hu, Ruiyu Xiang, Ran Mo, Zhongya Song, Zhiming Chen, Dan Bao, Di Hua, Christos C Zouboulis, Yanyan Feng, Ji Li, Yong Yang
Acne is a common chronic inflammatory disease of the pilosebaceous unit. Transient receptor potential vanilloid 3 (TRPV3) is an ion channel that is involved in inflammatory dermatosis development. However, the involvement of TRPV3 in acne-related inflammation remains unclear. Here, we used acne-like mice and human sebocytes to examine the role of TRPV3 in the development of acne. We found that TRPV3 expression increased in the skin lesions of Propionibacterium acnes (P. acnes)-injected acne-like mice and the facial sebaceous glands (SGs) of acne patients...
April 20, 2024: Biochimica et Biophysica Acta. Molecular Basis of Disease