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JOURNAL ARTICLE
J Yuan, G H Han
What are the new contents of the guideline since 2010?A.Patients with primary and non-primary sclerosing cholangitis (PSC) are included in these guidelines for the diagnosis and management of cholangiocarcinoma.B.Define "related stricture" as any biliary or hepatic duct stricture accompanied by the signs or symptoms of obstructive cholestasis and/or bacterial cholangitis.C.Patients who have had an inconclusive report from MRI and cholangiopancreatography should be reexamined by high-quality MRI/cholangiopancreatography for diagnostic purposes...
January 20, 2023: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
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JOURNAL ARTICLE
Rong Lyu, Weijuan Hu, Di Wang, Jiao Wang, Zhongsong Gao, Kefeng Jia
PURPOSE: To evaluate the role of ancillary features (AFs) of Liver Imaging Reporting and Data System (LI-RADS) in the diagnostic performance of small HCC (≤ 20 mm) on gadoxetic acid-enhanced MRI. METHODS: A total of 154 patients with 183 hepatic observations were analysed in this retrospective study. Observations were categorized using only major features (MFs) and combined MFs and AFs. Independently significant AFs were identified through logistic regression analysis, and upgraded LR-5 criteria were developed using these as new MFs...
March 20, 2023: Abdominal Radiology
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JOURNAL ARTICLE
Natália Tobar, Guilherme Z Rocha, Andrey Santos, Dioze Guadagnini, Heloísa B Assalin, Juliana A Camargo, Any E S S Gonçalves, Flavia R Pallis, Alexandre G Oliveira, Silvana A Rocco, Raphael M Neto, Irene Layane de Sousa, Marcos R Alborghetti, Maurício L Sforça, Patrícia B Rodrigues, Raissa G Ludwig, Emerielle C Vanzela, Sergio Q Brunetto, Patrícia A Boer, José A R Gontijo, Bruno Geloneze, Carla R O Carvalho, Patricia O Prada, Franco Folli, Rui Curi, Marcelo A Mori, Marco A R Vinolo, Celso D Ramos, Kleber G Franchini, Claudio F Tormena, Mario J A Saad
Metformin is the most prescribed drug for DM2, but its site and mechanism of action are still not well established. Here, we investigated the effects of metformin on basolateral intestinal glucose uptake (BIGU), and its consequences on hepatic glucose production (HGP). In diabetic patients and mice, the primary site of metformin action was the gut, increasing BIGU, evaluated through PET-CT. In mice and CaCo2 cells, this increase in BIGU resulted from an increase in GLUT1 and GLUT2, secondary to ATF4 and AMPK...
January 24, 2023: Proceedings of the National Academy of Sciences of the United States of America
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JOURNAL ARTICLE
Thiago Moreno L Souza, Vagner D Pinho, Cristina F Setim, Carolina Q Sacramento, Rodrigo Marcon, Natalia Fintelman-Rodrigues, Otavio A Chaves, Melina Heller, Jairo R Temerozo, André C Ferreira, Mayara Mattos, Patrícia B Momo, Suelen S G Dias, João S M Gesto, Filipe Pereira-Dutra, João P B Viola, Celso Martins Queiroz-Junior, Lays Cordeiro Guimarães, Ian Meira Chaves, Pedro Pires Goulart Guimarães, Vivian Vasconcelos Costa, Mauro Martins Teixeira, Dumith Chequer Bou-Habib, Patrícia T Bozza, Anderson R Aguillón, Jarbas Siqueira-Junior, Sergio Macedo-Junior, Edineia L Andrade, Guilherme P Fadanni, Sara E L Tolouei, Francine B Potrich, Adara A Santos, Naiani F Marques, João B Calixto, Jaime A Rabi
Orally available antivirals against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are necessary because of the continuous circulation of new variants that challenge immunized individuals. Because severe COVID-19 is a virus-triggered immune and inflammatory dysfunction, molecules endowed with both antiviral and anti-inflammatory activity are highly desirable. We identified here that kinetin (MB-905) inhibits the in vitro replication of SARS-CoV-2 in human hepatic and pulmonary cell lines. On infected monocytes, MB-905 reduced virus replication, IL-6 and TNFα levels...
January 13, 2023: Nature Communications
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JOURNAL ARTICLE
Pierpaolo Trimboli, Nicola Ossola, Alessandro Torre, Francesco Mongelli, Massimo Quarenghi, Chiara Camponovo, Barbara Lucchini, Mario Rotondi, Lorenzo Ruinelli, Fabio Garofalo
OBJECTIVE: The aim was to evaluate if bariatric surgery can affect the LT4 performance. The endpoints were the following: 1) difference between LT4 daily dose before and 1 year after surgery, 2) difference between LT4 dose per weight before and 1 year after surgery, 3) difference among LT4 preparations. METHODS: The study period was between January 2018 and May 2022. Inclusion criteria were a) adults undergone bariatric surgery, b) with proven autoimmune hypothyroidism, c) on LT4 therapy before bariatric surgery, d) using any commercialized LT4 preparation...
December 29, 2022: Endocrine
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JOURNAL ARTICLE
Asaf A Qureshi
δ-Tocotrienol plus AHA Step-1 diet in hypercholesterolemic subjects caused reductions in lipid parameters (14% to 18%) with 250 mg/d dose, and 500 mg/d resulted induction in these parameters. Although, α-tocopherol is the most bioavailable form of vitamin E. There are few reports on bioavailability of tocotrienols in humans. Pharmacokinetics and bioavailability of δ-tocotrienol was quantified on plasma levels of tocol isomers, cytokines, and microRNAs. Subjects were fed doses of 125 mg/d to 500 mg/d...
July 2022: Annals of Clinical Case Reports
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JOURNAL ARTICLE
Fumihito Toshima, Norihide Yoneda, Kanako Terada, Dai Inoue, Toshifumi Gabata
Evaluating the similarity between two entities such as primary and suspected metastatic lesions using quantitative dual-energy computed tomography (DECT) numbers may be useful. However, the criteria for the similarity between two entities based on DECT numbers remain unclear. We therefore considered the possibility that a similarity in DECT numbers within the same organ could provide suitable standards. Thus, we assumed that the variation in DECT numbers within a single organ is sufficiently minimal to be considered clinically equivalent...
November 4, 2022: Tomography: a Journal for Imaging Research
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JOURNAL ARTICLE
V R Muñoz, R C Gaspar, M C S Mancini, R D de Lima, R F L Vieira, B M Crisol, G C Antunes, J C S Trombeta, I L P Bonfante, F M Simabuco, A S R da Silva, C R Cavaglieri, E R Ropelle, D E Cintra, J R Pauli
PURPOSE: Aging is associated with changes in glucose homeostasis related to both decreased insulin secretion and/or impaired insulin action, contributing to the high prevalence of type 2 diabetes (T2D) in the elderly population. Additionally, studies are showing that chronically high levels of circulating insulin can also lead to insulin resistance. In contrast, physical exercise has been a strategy used to improve insulin sensitivity and metabolic health. However, the molecular alterations resulting from the effects of physical exercise in the liver on age-related hyperinsulinemia conditions are not yet fully established...
November 1, 2022: Journal of Endocrinological Investigation
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JOURNAL ARTICLE
Tarfah Al-Warhi, Al-Aliaa M Sallam, Loah R Hemeda, Mahmoud A El Hassab, Nada Aljaeed, Ohoud J Alotaibi, Ahmed S Doghish, Mina Noshy, Wagdy M Eldehna, Mona H Ibrahim
In the current work, we designed and synthesized three families of non-fused and fused compounds based on cyanopyridone: derivatives of 6-amino-1,2-dihydropyridine-3,5-dicarbonitrile ( 5a-f ) and 3,4,7,8-tetrahydro pyrimidine-6-carbonitrile ( 6a-b and 7a-e ). The newly synthesized compounds' structure were determined using a variety of techniques, including 1 H NMR, 13 C NMR, mass spectrum, infrared spectroscopy, and elemental analysis. The developed compounds were tested for the ability to inhibit the growth of breast adenocarcinoma (MCF-7) and hepatic adenocarcinoma (HepG2) cell lines using MTT assay...
October 13, 2022: Pharmaceuticals
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JOURNAL ARTICLE
Chinenye F Umego, Clement I Mboto, Atim D Asitok, Linda C Osaji, Uwem E George, Uwem O Edet, Elizabeth N Mbim, Temitope Oc Faleye, Olubusuyi M Adewumi, Johnson A Adeniji
Introduction: Hepatitis B virus (HBV) infection continues to be a significant public health challenge globally, with higher disease burden in developing countries. HBV genotypes are associated with different geographical regions and clinical outcomes. Limited information exists on epidemiology of HBV in the Niger-Delta region (South-South) of Nigeria. Consequently, this study was designed to characterise hepatitis B virus infection among outpatients in selected tertiary hospitals in the region...
March 2022: African Health Sciences
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JOURNAL ARTICLE
D A Ibarrola, W Arrua, J E Gonzalez, M S Soverina Escobar, J Centurión, A M Campuzano Benitez, F M Ovando Soria, E I Rodas González, K G Arrúa, M B Acevedo Barrios, O Y Heinichen, Y Montalbetti, M A Campuzano-Bublitz, M L Kennedy, S J Figueredo Thiel, N L Alvarenga, M C Hellión-Ibarrola
ETHNOPHARMACOLOGICAL RELEVANCE: Solanum sisymbriifolium Lam., is used in Paraguayan folk medicine claiming antihypertensive and diuretic properties. AIM OF THE STUDY: This study aimed to determine the influence of chronic oral administration of the crude root extract and saponins obtained from S. sisymbriifolium Lam., on the blood pressure of male and female rats with hypertension induced by L-NAME, and its consequences on diuresis, the body weight, blood glucose, and level of serum parameters of liver and kidney functionality...
August 13, 2022: Journal of Ethnopharmacology
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JOURNAL ARTICLE
D N Coleman, P Totakul, N Onjai-Uea, A Aboragah, Q Jiang, M Vailati-Riboni, R T Pate, D Luchini, P Paengkoum, M Wanapat, F C Cardoso, J J Loor
We investigated effects of rumen-protected Met (RPM) during a heat stress (HS) challenge on (1) hepatic abundance of mTOR, insulin, and antioxidant signaling proteins, (2) enzymes in 1-carbon metabolism, and (3) innate immunity. Holstein cows (n = 32; mean ± standard deviation, 184 ± 59 d in milk) were randomly assigned to 1 of 2 environmental groups, and 1 of 2 diets [total mixed ration (TMR) with RPM (Smartamine M; 0.105% dry matter as top-dress) or TMR without (CON); n = 16/diet] in a split-plot crossover design...
July 22, 2022: Journal of Dairy Science
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JOURNAL ARTICLE
R Korenblik, B Olij, L A Aldrighetti, M Abu Hilal, M Ahle, B Arslan, L J van Baardewijk, I Baclija, C Bent, C L Bertrand, B Björnsson, M T de Boer, S W de Boer, R P H Bokkers, I H M Borel Rinkes, S Breitenstein, R C G Bruijnen, P Bruners, M W Büchler, J C Camacho, A Cappelli, U Carling, B K Y Chan, D H Chang, J Choi, J Codina Font, M Crawford, D Croagh, E Cugat, R Davis, D W De Boo, F De Cobelli, J F De Wispelaere, O M van Delden, M Delle, O Detry, R Díaz-Nieto, A Dili, J I Erdmann, O Fisher, C Fondevila, Å Fretland, F Garcia Borobia, A Gelabert, L Gérard, F Giuliante, P D Gobardhan, F Gómez, T Grünberger, D J Grünhagen, J Guitart, J Hagendoorn, J Heil, D Heise, E Herrero, G F Hess, M H Hoffmann, R Iezzi, F Imani, J Nguyen, E Jovine, J C Kalff, G Kazemier, T P Kingham, J Kleeff, O Kollmar, W K G Leclercq, S Lopez Ben, V Lucidi, A MacDonald, D C Madoff, S Manekeller, G Martel, A Mehrabi, H Mehrzad, M R Meijerink, K Menon, P Metrakos, C Meyer, A Moelker, S Modi, N Montanari, J Navines, U P Neumann, P Peddu, J N Primrose, X Qu, D Raptis, F Ratti, F Ridouani, C Rogan, U Ronellenfitsch, S Ryan, C Sallemi, J Sampere Moragues, P Sandström, L Sarriá, A Schnitzbauer, M Serenari, A Serrablo, M L J Smits, E Sparrelid, E Spüntrup, G A Stavrou, R P Sutcliffe, I Tancredi, J C Tasse, V Udupa, D Valenti, Y Fundora, T J Vogl, X Wang, S A White, W A Wohlgemuth, D Yu, I A J Zijlstra, C A Binkert, M H A Bemelmans, C van der Leij, E Schadde, R M van Dam
STUDY PURPOSE: The DRAGON 1 trial aims to assess training, implementation, safety and feasibility of combined portal- and hepatic-vein embolization (PVE/HVE) to accelerate future liver remnant (FLR) hypertrophy in patients with borderline resectable colorectal cancer liver metastases. METHODS: The DRAGON 1 trial is a worldwide multicenter prospective single arm trial. The primary endpoint is a composite of the safety of PVE/HVE, 90-day mortality, and one year accrual monitoring of each participating center...
July 5, 2022: Cardiovascular and Interventional Radiology
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JOURNAL ARTICLE
Rocío Trastoy, José María Gonzalez-Alba, Vicente Soriano, José Javier Rodriguez-Calviño, Carmen de Mendoza, José Javier Costa, María Cea, Gema Barbeito, Octavio Corral, Félix Gómez-Gallego, María Luisa Pérez Del Molino, Juan Carlos Galán, Antonio Aguilera
BACKGROUND: Hepatitis B virus (HBV) comprises 9 genotypes and multiple subgenotypes that depict differences in geographic distribution, clinical outcome and response to antiviral therapy. However, the molecular epidemiology of HBV geno/subgenotypes is globally scarce. In Spain, HBV genotype D seems to be more prevalent in the northwestern regions compared to the rest of the country for unclear reasons. METHODS: HBV genotyping was performed using geno2pheno on a S gene fragment amplified from plasma collected from all chronic hepatitis B individuals attended at one reference hospital in Santiago de Compostela, the Galicia's capital town...
May 30, 2022: Journal of Clinical Virology
#35
JOURNAL ARTICLE
Raquel D Greca, Marlone Cunha-Silva, Daniel F Mazo, Larissa B E Costa, Elaine C Ataíde, Ilka F S F Boin, Tiago Sevá-Pereira
Hepatocellular carcinoma (HCC) is the most common primary liver malignancy, accounting for up to 90% of all primary liver neoplasms. HCC treatment options depend on tumor burden, the degree of liver dysfunction, and performance status. Orthotopic liver transplant offers the best chance for cure. The selection criteria adopted for transplant are based on the Milan Criteria (MC), which depend on tumor size and number (1 lesion ≤5 cm or up to 3 lesions of ≤3 cm, without vascular invasion or extrahepatic spread)...
May 25, 2022: Transplantation Proceedings
#36
JOURNAL ARTICLE
Weitao Ye, Wanqun Yang, Chengwei Guo, Chenyu Dong, Feng Shi, Changhong Liang
PURPOSE We aimed to explore the effect of microwave ablation (MWA) protocols upon morphology and instant changes in intravoxel incoherent motion (IVIM) diffusion-weighted imaging (DWI) parameters on MWA zones in porcine livers. METHODS According to the empirical protocol for MWA in tumors less than 3 cm in our hospital, the power and application duration were assigned as five groups: A, 60 W × 5 min (n = 6); B, 80 W × 3 min (n = 7); C, 80 W × 5 min (n = 10); D, 100 W × 3 min (n = 10); E, 100 W × 5 min (n = 9)...
March 2022: Diagnostic and Interventional Radiology: Official Journal of the Turkish Society of Radiology
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JOURNAL ARTICLE
F D Wang, J Zhou, D M Zhang, M L Wang, Y C Tao, D B Wu, H Tang, E Q Chen
Objective: To investigate the effectiveness of nucleos(t)ide analogues in the treatment of HBeAg-positive chronic hepatitis B with normal alanine aminotransferase and high level of HBV DNA. Methods: Treatment-naïve chronic hepatitis B patients who were followed up at the Center of Infectious Diseases, West China Hospital of Sichuan University from January 2019 to January 2020 were selected as subjects. Demographic characteristics, the results of laboratory examination before treatment and one year after treatment were retrospectively collected...
April 20, 2022: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
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JOURNAL ARTICLE
Yidi Qin, Kate F Kernan, Zhenjiang Fan, Hyun-Jung Park, Soyeon Kim, Scott W Canna, John A Kellum, Robert A Berg, David Wessel, Murray M Pollack, Kathleen Meert, Mark Hall, Christopher Newth, John C Lin, Allan Doctor, Tom Shanley, Tim Cornell, Rick E Harrison, Athena F Zuppa, Russell Banks, Ron W Reeder, Richard Holubkov, Daniel A Notterman, J Michael Dean, Joseph A Carcillo
BACKGROUND: Thrombotic microangiopathy-induced thrombocytopenia-associated multiple organ failure and hyperinflammatory macrophage activation syndrome are important causes of late pediatric sepsis mortality that are often missed or have delayed diagnosis. The National Institutes of General Medical Science sepsis research working group recommendations call for application of new research approaches in extant clinical data sets to improve efficiency of early trials of new sepsis therapies...
May 7, 2022: Critical Care: the Official Journal of the Critical Care Forum
#39
JOURNAL ARTICLE
Merel B Klunder, Janneke L M Bruggink, Leon D H Huynh, Frank A J A Bodewes, Alida F W van der Steeg, Kathelijne C J M Kraal, C P Kees van de Ven, Martine van Grotel, József Zsiros, Marc H W A Wijnen, I Q Quintus Molenaar, Robert J Porte, Vincent E de Meijer, Ruben H de Kleine
INTRODUCTION: Six to eight children are diagnosed with a malignant liver tumour yearly in the Netherlands. The majority of these tumours are hepatoblastoma (HB) and hepatocellular carcinoma (HCC), for which radical resection, often in combination with chemotherapy, is the only curative treatment option. We investigated the surgical outcome of children with a malignant liver tumour in a consecutive cohort in the Netherlands. METHODS: In this nationwide, retrospective observational study, all patients (age < 18 years) diagnosed with a malignant liver tumour, who underwent partial liver resection or orthotopic liver transplantation (OLT) between January 2014 and April 2021, were included...
April 7, 2022: Children
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JOURNAL ARTICLE
H Mosbah, B Donadille, C Vatier, S Janmaat, M Atlan, C Badens, P Barat, S Béliard, J Beltrand, R Ben Yaou, E Bismuth, F Boccara, B Cariou, M Chaouat, G Charriot, S Christin-Maitre, M De Kerdanet, B Delemer, E Disse, N Dubois, B Eymard, B Fève, O Lascols, P Mathurin, E Nobécourt, A Poujol-Robert, G Prevost, P Richard, J Sellam, I Tauveron, D Treboz, B Vergès, V Vermot-Desroches, K Wahbi, I Jéru, M C Vantyghem, C Vigouroux
Dunnigan syndrome, or Familial Partial Lipodystrophy type 2 (FPLD2; ORPHA 2348), is a rare autosomal dominant disorder due to pathogenic variants of the LMNA gene. The objective of the French National Diagnosis and Care Protocol (PNDS; Protocole National de Diagnostic et de Soins), is to provide health professionals with a guide to optimal management and care of patients with FPLD2, based on a critical literature review and multidisciplinary expert consensus. The PNDS, written by members of the French National Reference Center for Rare Diseases of Insulin Secretion and Insulin Sensitivity (PRISIS), is available on the French Health Authority website (in French)...
April 19, 2022: Orphanet Journal of Rare Diseases
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