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https://www.readbyqxmd.com/read/27917597/chronic-hepatitis-c-infection-and-liver-disease-in-hiv-coinfected-patients-in-asia
#1
N Durier, E Yunihastuti, K Ruxrungtham, N V Kinh, A Kamarulzaman, D Boettiger, A Widhani, A Avihingsanon, B V Huy, S F B Syed Omar, A Sanityoso, S Chittmittrapap, N T H Dung, V Pillai, T Suwan-Ampai, M Law, A H Sohn, G Matthews
Data on markers of hepatitis C virus (HCV) disease in HIV-HCV-coinfected patients in resource-limited settings are scarce. We assessed HCV RNA, HCV genotype (GT), IL28B GT and liver fibrosis (FibroScan(®) ) in 480 HIV-infected patients with positive HCV antibody in four HIV treatment centres in South-East Asia. We enrolled 165 (34.4%) patients in Jakarta, 158 (32.9%) in Bangkok, 110 (22.9%) in Hanoi and 47 (9.8%) in Kuala Lumpur. Overall, 426 (88.8%) were male, the median (IQR) age was 38.1 (34.7-42.5) years, 365 (76...
December 5, 2016: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/27896822/simeprevir-in-combination-with-sofosbuvir-in-treatment-na%C3%A3-ve-and-experienced-patients-with-hepatitis-c-virus-genotype-4-infection-a-phase-iii-open-label-single-arm-study-pluto
#2
M Buti, J L Calleja, S Lens, M Diago, E Ortega, J Crespo, R Planas, M Romero-Gómez, F G Rodríguez, J M Pascasio, B Fevery, D Kurland, C Corbett, R Kalmeijer, W Jessner
BACKGROUND: Hepatitis C virus (HCV) infection is a leading cause of liver cirrhosis and subsequent hepatocellular carcinoma. HCV genotype 4 is found widely in the Middle East, Egypt and Africa, and has also spread into Europe. There are limited data available regarding the use of direct-acting antiviral agents in HCV genotype 4-infected patients with cirrhosis. AIM: The Phase III, open-label, single-arm PLUTO study evaluated the efficacy and safety of 12 weeks of simeprevir (HCV NS3/4A protease inhibitor) plus sofosbuvir (HCV nucleotide-analogue NS5B polymerase inhibitor) in treatment-naïve and (peg)interferon ± ribavirin-experienced HCV genotype 4-infected patients, with or without compensated cirrhosis...
November 29, 2016: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/27893760/leaf-extract-from-lithocarpus-polystachyus-rehd-promote-glycogen-synthesis-in-t2dm-mice
#3
Jinfei Wang, Yumin Huang, Kaixiang Li, Yingying Chen, Diana Vanegas, Eric Scott McLamore, Yingbai Shen
The purpose of this study was to investigate the effects of leaf extract from Lithocarpus polystachyus Rehd. on type II diabetes mellitus (T2DM) and the active ingredients of this effect. In addition, this study determined, for the first time, the underlying molecular and pharmacological mechanisms of the extracts on hyperglycemia using long-term double high diet-fed and streptozotocin (STZ) induced type II diabetic mice. In the present study, leaf extract, phloridzin and trilobatin were assessed in vivo (gavage) and in vitro (non-invasive micro-test technique, NMT) in experimental T2DM mice...
2016: PloS One
https://www.readbyqxmd.com/read/27891715/baseline-hepatitis-b-core-antibody-predicts-treatment-response-in-chronic-hepatitis-b-patients-receiving-long-term-entecavir
#4
J-H Xu, L-W Song, N Li, S Wang, Z Zeng, C-W Si, J Li, Q Mao, D-Z Zhang, H Tang, J-F Sheng, X-Y Chen, Q Ning, G-F Shi, Q Xie, Q Yuan, Y-Y Yu, N-S Xia
Studies regarding the clinical significance of quantitative hepatitis B core antibody (anti-HBc) in patients with chronic hepatitis B receiving first-line nucleos(t)ide analogues is limited. The aim of this study was to determine the performance of anti-HBc as a predictor for hepatitis B e antigen (HBeAg) seroconversion in HBeAg-positive CHB patients treated with entecavir. This was a retrospective cohort study consisting of 139 Chinese patients enrolled in a multicenter clinical trial treated with entecavir or entecavir maleate for up to 240 weeks...
November 28, 2016: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/27878906/simeprevir-daclatasvir-and-sofosbuvir-for-hepatitis-c-virus-infected-patients-with-decompensated-liver-disease
#5
E Lawitz, F Poordad, J A Gutierrez, T N Kakuda, G Picchio, G Beets, A Vandevoorde, P Van Remoortere, B Jacquemyn, D Luo, S Ouwerkerk-Mahadevan, L Vijgen, V Van Eygen, M Beumont
Approximately three million individuals in the United States are chronically infected with hepatitis C virus (HCV). Chronic HCV infection may lead to the development of compensated as well as decompensated liver cirrhosis. The Phase II IMPACT study was conducted in HCV genotype 1- or 4-infected cirrhotic patients with portal hypertension or decompensated liver disease and assessed for the first time the combination of the three direct-acting antivirals simeprevir, daclatasvir and sofosbuvir. Treatment-naïve or treatment-experienced adults with Child-Pugh (CP) score <7 (CP A) and evidence of portal hypertension, or CP score 7-9 (CP B), received 12 weeks of simeprevir 150 mg, daclatasvir 60 mg and sofosbuvir 400 mg, once daily...
November 23, 2016: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/27853723/evaluation-of-the-protective-role-of-vitamin-c-on-the-metabolic-and-enzymatic-activities-of-the-liver-in-the-male-rats-after-exposure-to-2-45-ghz-of-wi-fi-routers
#6
F Shekoohi-Shooli, S M J Mortazavi, M B Shojaei-Fard, S Nematollahi, M Tayebi
BACKGROUND: The use of devices emitted microwave radiation such as mobile phones, wireless fidelity (Wi-Fi) routers, etc. is increased rapidly. It has caused a great concern; the researchers should identify its effects on people's health. We evaluated the protective role of Vitamin C on the metabolic and enzymatic activities of the liver after exposure to Wi-Fi routers. MATERIAL AND METHODS: 70 male Wistar rats weighing 200-250 g were randomly divided into 7 groups (10 rats in each group)...
September 2016: Journal of Biomedical Physics & Engineering
https://www.readbyqxmd.com/read/27843753/bioinformatic-curation-and-alignment-of-genotyped-hepatitis-b-virus-hbv-sequence-data-from-the-genbank-public-database
#7
Trevor G Bell, Mukhlid Yousif, Anna Kramvis
BACKGROUND: Hepatitis B virus (HBV) DNA sequence data from thousands of samples are present in the public sequence databases. No publicly available, up-to-date, multiple sequence alignments, containing full-length and subgenomic fragments per genotype, are available. Such alignments are useful in many analysis applications, including data-mining and phylogenetic analyses. RESULTS: By issuing a query, all HBV sequence data from the GenBank public database was downloaded (67,893 sequences)...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27816492/tremelimumab-in-combination-with-ablation-in-patients-with-advanced-hepatocellular-carcinoma
#8
Austin G Duffy, Susanna V Ulahannan, Oxana Makorova-Rusher, Osama Rahma, Heiner Wedemeyer, Drew Pratt, Jeremy L Davis, Marybeth S Hughes, Theo Heller, Mei ElGindi, Ashish Uppala, Firouzeh Korangy, David E Kleiner, William D Figg, David Venzon, Seth M Steinberg, Aradhana M Venkatesan, Venkatesh Krishnasamy, Nadine Abi-Jaoudeh, Elliot Levy, Brad J Wood, Tim F Greten
BACKGROUND: Tremelimumab is a fully human monoclonal antibody that binds to CTLA-4 on the surface of activated T lymphocytes. Ablative therapies have been shown to induce a peripheral immune response which may enhance the effect of anti-CTLA4 treatment in patients with advanced HCC. METHODS: Patients with HCC [Childs Pugh A/B7; Barcelona Clinic Liver Cancer Stage B/C; ECOG 0/1] were enrolled in a study of tremelimumab in combination with an ablative procedure performed during week 6...
November 2, 2016: Journal of Hepatology
https://www.readbyqxmd.com/read/27785710/diagnostic-accuracy-of-transient-elastography-for-detecting-liver-fibrosis-after-liver-trannsplantation-a-specific-cut-off-value-is-really-needed
#9
B Della-Guardia, A S Evangelista, G E Felga, L V Marins, P R Salvalaggio, M D Almeida
INTRODUCTION: Liver transplant recipients often perform liver biopsy (LB), specially in the context of potentially recurring diseases, such as hepatitis C infection. However, the LB has risks of complications, despite being the gold standard. Transient elastography (TE) is a noninvasive method comparable to the LB to evaluate liver fibrosis in various settings, but its accuracy among transplant recipients is not fully understood. OBJECTIVE: To determine the accuracy of TE in liver transplant recipients compared with LB to successfully predict liver fibrosis...
October 26, 2016: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/27693161/hepatitis-b-virus-genetic-diversity-has-minimal-impact-on-sensitivity-of%C3%A2-the-viral-ribonuclease-h-to-inhibitors
#10
Gaofeng Lu, Juan Antonio Villa, Maureen J Donlin, Tiffany C Edwards, Xiaohong Cheng, Richard F Heier, Marvin J Meyers, John E Tavis
Hepatitis B virus (HBV) causes hepatitis, cirrhosis, liver failure, and liver cancer, but the current therapies that employ either nucelos(t)ide analogs or (pegylated)interferon α do not clear the infection in the large majority of patients. Inhibitors of the HBV ribonuclease H (RNaseH) that are being developed with the goal of producing anti-HBV drugs are promising candidates for use in combination with the nucleos(t)ide analogs to improve therapeutic efficacy. HBV is genetically very diverse, with at least 8 genotypes that differ by ≥8% at the sequence level...
November 2016: Antiviral Research
https://www.readbyqxmd.com/read/27658343/no-detectable-resistance-to-tenofovir-disoproxil-fumarate-in-hbeag-and-hbeag-patients-with-chronic-hepatitis-b-after-8%C3%A2-years-of-treatment
#11
Y Liu, A C Corsa, M Buti, A L Cathcart, J F Flaherty, M D Miller, K M Kitrinos, P Marcellin, E J Gane
A major hurdle in the long-term treatment of chronic hepatitis B (CHB) patients is to maintain viral suppression in the absence of drug resistance. To date, no evidence of resistance to tenofovir disoproxil fumarate (TDF) has been observed. A cumulative evaluation of CHB patients who qualified for resistance surveillance over 8 years of TDF treatment was conducted. Patients in studies GS-US-174-0102 (HBeAg-) and GS-US-174-0103 (HBeAg+) were randomized 2:1 to receive TDF or adefovir dipivoxil (ADV) for 48 weeks followed by open-label TDF through year 8...
September 23, 2016: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/27630169/galectin-3-regulates-inflammasome-activation-in-cholestatic-liver-injury
#12
Jijing Tian, Guoxiang Yang, Huan-Yuan Chen, Daniel K Hsu, Alexey Tomilov, Kristin A Olson, Ali Dehnad, Sarah R Fish, Gino Cortopassi, Bin Zhao, Fu-Tong Liu, M Eric Gershwin, Natalie J Török, Joy X Jiang
Macrophage activation is an important feature of primary biliary cholangitis (PBC) pathogenesis and other cholestatic liver diseases. Galectin-3 (Gal3), a pleiotropic lectin, is produced by monocytic cells and macrophages. However, its role in PBC has not been addressed. We hypothesized that Gal3 is a key to induce NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome in macrophages and in turn to propagate proinflammatory IL-17 signaling. In liver tissues from patients with PBC and dnTGF-βRII mice, a model of autoimmune cholangitis, the expression of Gal3, NLRP3, and the adaptor protein adaptor apoptosis-associated speck-like protein was induced, with the downstream activation of caspase-1 and IL-1β...
December 2016: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/27629859/predictors-of-response-to-tenofovir-disoproxil-fumarate-plus-peginterferon-alfa-2a-combination-therapy-for-chronic-hepatitis-b
#13
P Marcellin, S H Ahn, W-L Chuang, A J Hui, F Tabak, R Mehta, J Petersen, C-M Lee, X Ma, F A Caruntu, W Y Tak, M Elkhashab, L Lin, G Wu, E B Martins, P Charuworn, L J Yee, S G Lim, G R Foster, S Fung, L Morano, D Samuel, K Agarwal, R Idilman, S I Strasser, M Buti, G B Gaeta, G Papatheodoridis, R Flisiak, H L Y Chan
BACKGROUND: In patients with chronic hepatitis B, tenofovir disoproxil fumarate (TDF) plus pegylated interferon (PEG-IFN) for 48-weeks results in higher rates of hepatitis B surface antigen (HBsAg) loss than either monotherapy. AIM: To identify baseline and on-treatment factors associated with HBsAg loss at Week 72 and provide a model for predicting HBsAg loss in patients receiving combination therapy for 48 weeks. METHODS: A secondary analysis of data from an open-label study where patients were randomised to TDF (300 mg/day, oral) plus PEG-IFN (PI, 180 μg/week, subcutaneous) for 48 weeks (TDF/PI-48w); TDF plus PEG-IFN for 16 weeks, TDF for 32 weeks (TDF/PI-16w+TDF-32w); TDF for 120 weeks (TDF-120w) or PEG-IFN for 48 weeks (PI-48w)...
November 2016: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/27577976/hepatitis-b-core-related-antigen-kinetics-in-chronic-hbv-genotype-d-infected-patients-treated-with-nucleos-t-ide-analogues-or-pegylated-interferon-%C3%AE
#14
G P Caviglia, M L Abate, D Noviello, A Olivero, C Rosso, G Troshina, A Ciancio, M Rizzetto, G M Saracco, A Smedile
AIM: To evaluate Hepatitis B core-related antigen (HBcrAg) correlation with HBV DNA and hepatitis B surface antigen (HBsAg) levels and to investigate HBcrAg kinetic during nucleos(t)ide analogues (NAs) or pegylated-interferon (PEG-IFN)-α treatment in a cohort of chronic hepatitis B (CHB)-genotype-D patients. METHODS: One-hundred-thirty-eight sequential serum samples were collected from 28 Hepatitis B e antigen (HBeAg)-negative CHB-genotype-D patients (20 M/8 F; median age 54 [47-58] years), who underwent NAs (n = 20) or PEG-IFN-α (n = 8) treatment...
August 30, 2016: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/27570087/ofatumumab-monotherapy-as-a-consolidation-strategy-in-patients-with-previously-untreated-chronic-lymphocytic-leukaemia-a-phase-2-trial
#15
Paolo Strati, Mark Lanasa, Timothy G Call, Jose F Leis, Danielle M Brander, Betsy R LaPlant, Adam M Pettinger, Wei Ding, Sameer A Parikh, Curtis A Hanson, Asher A Chanan-Khan, Deborah A Bowen, Michael Conte, Neil E Kay, Tait D Shanafelt
BACKGROUND: Although several consolidation strategies to prolong treatment-free survival (TFS) in chronic lymphocytic leukaemia have been investigated, most have proven either ineffective or toxic. Ofatumumab is a human type I anti-CD20 antibody approved by the US Food and Drug Administration as maintenance treatment of patients with recurrent or progressive chronic lymphocytic leukaemia who are in complete or partial response after at least two lines of treatment; higher efficacy might be observed if used as consolidation strategy than without consolidation in previously untreated patients...
September 2016: Lancet Haematology
https://www.readbyqxmd.com/read/27565427/distribution-and-clinical-significance-of-hepatitis-b-virus-genotypes-in-pakistan
#16
Majid Mahmood, Muhammad Asim Anwar, Azra Khanum, Nasib Zaman, Abida Raza
BACKGROUND: Hepatitis B virus (HBV) genotype and its role in disease progression and patients' response to antiviral treatment, is not well studied in Pakistan. This comprehensive study was aimed to determine the distribution of HBV genotypes in Pakistan and their possible association with phases of HBV infection. METHODS: A total of 840 HBsAg positive samples was collected and tested for HBV DNA quantity. Samples below 100 IU/ml were excluded from the study. A total of 715 samples representing all the six parts of the country were genotyped by type specific primer PCR method...
August 26, 2016: BMC Gastroenterology
https://www.readbyqxmd.com/read/27510870/-a-retrospective-study-on-the-liver-pathological-characteristics-and-the-effect-of-antiviral-treatment-for-1-to-7-years-old-children-with-heptitis-b-e-antigen-negative-chronic-hepatitis-b
#17
S S Zhu, Y Dong, L M Wang, Z Q Xu, D W Chen, Y Gan, F C Wang, J G Yan, L L Cao, P Wang, M Zhang, H F Zhang
OBJECTIVE: To investigate the liver pathological characteristics and the clearance rate of hepatitis B surface antigen (HBsAg) with antiviral treatment for 1 to 7 years old children with heptitis B e antigen(HBeAg)-negative chronic hepatitis B. METHOD: A total of 49 cases with HBeAg-negative chronic hepatitis B were treated with interferon (IFN) or IFN treatment for 6 months added with lamivudine, and were followed up for at least 6 months.Retrospective analysis was performed on the liver pathological characteristics, the efficacy of antivirus treatment and its influencing factors of the HBsAg clearance rate in the cases from June 2006 to December 2013 in the 302 Hospital of People's Liberation Army...
August 2016: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/27496750/breath-print-analysis-by-e-nose%C3%A2-may-refine%C3%A2-risk-stratification%C3%A2-for%C3%A2-adverse-outcomes-in-cirrhotic-patients
#18
Antonio De Vincentis, Giorgio Pennazza, Marco Santonico, Umberto Vespasiani-Gentilucci, Giovanni Galati, Paolo Gallo, Alessandro Zompanti, Claudio Pedone, Raffaele Antonelli Incalzi, Antonio Picardi
BACKGROUND & AIMS: The spectrum of volatile organic compounds in the exhaled breath (breath-print, BP) has been shown to characterize patients with liver cirrhosis and with worse hepatic function. However, the association of different BPs with clinically relevant outcomes has not been described yet. Hence, we aimed to evaluate the association between BPs, mortality and hospitalization in cirrhotic patients and to compare it with that of the "classical" prognostic indices (Child-Pugh classification [CPC] and MELD)...
August 6, 2016: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/27441903/elevated-plasma-angiopoietin-2-levels-are-associated-with-fluid-overload-organ-dysfunction-and-mortality-in-human-septic-shock
#19
Jane Fisher, James J Douglas, Adam Linder, John H Boyd, Keith R Walley, James A Russell
OBJECTIVES: Angiopoietins modulate endothelial permeability via endothelial cell junctions. Angiopoietin-2 blocks the angiopoietin-1/Tie-2 interaction that stabilizes these junctions, and elevated plasma angiopoietin-2 levels are associated with vascular leakage. We hypothesized that plasma angiopoietin-1 and angiopoietin-2 levels are associated with indirect markers of increased vascular permeability, organ dysfunction, mortality, and plasma proinflammatory cytokine levels in human septic shock...
November 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27400856/genome-wide-common-and-rare-variant-analysis-provides-novel-insights-into-clozapine-associated-neutropenia
#20
S E Legge, M L Hamshere, S Ripke, A F Pardinas, J I Goldstein, E Rees, A L Richards, G Leonenko, L F Jorskog, K D Chambert, D A Collier, G Genovese, I Giegling, P Holmans, A Jonasdottir, G Kirov, S A McCarroll, J H MacCabe, K Mantripragada, J L Moran, B M Neale, H Stefansson, D Rujescu, M J Daly, P F Sullivan, M J Owen, M C O'Donovan, J T R Walters
The antipsychotic clozapine is uniquely effective in the management of schizophrenia; however, its use is limited by its potential to induce agranulocytosis. The causes of this, and of its precursor neutropenia, are largely unknown, although genetic factors have an important role. We sought risk alleles for clozapine-associated neutropenia in a sample of 66 cases and 5583 clozapine-treated controls, through a genome-wide association study (GWAS), imputed human leukocyte antigen (HLA) alleles, exome array and copy-number variation (CNV) analyses...
July 12, 2016: Molecular Psychiatry
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