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https://www.readbyqxmd.com/read/28828681/role-of-epithelial-mesenchymal-transition-involved-molecules-in-the-progression-of-cutaneous-melanoma
#1
Daniela Murtas, Cristina Maxia, Andrea Diana, Luca Pilloni, Claudia Corda, Luigi Minerba, Sara Tomei, Franca Piras, Caterina Ferreli, Maria Teresa Perra
Epithelial-mesenchymal transition (EMT) has been suggested to have a driving role in the acquisition of a metastatic potential by melanoma cells. Important hallmarks of EMT include both E-cadherin downregulation and increased expression of N-cadherin. This switch in distinct classes of adhesion molecules leads melanoma cells to lose contact with adjacent keratinocytes and interact instead with stromal fibroblasts and endothelial cells, thus promoting dermal and vascular melanoma invasion. Consequently, tumor cells migrate to distant host tissues and establish metastases...
August 21, 2017: Histochemistry and Cell Biology
https://www.readbyqxmd.com/read/28818109/metastatic-colorectal-cancer-responsive-to-regorafenib-for-2-years-a-case-report
#2
Kenji Yoshino, Dai Manaka, Ryo Kudo, Shunpei Kanai, Eisei Mitsuoka, Satoshi Kanto, Shinya Hamasu, Sayuri Konishi, Ryuta Nishitai
BACKGROUND: Regorafenib is an oral multikinase inhibitor that has been demonstrated as clinically effective in patients with metastatic colorectal cancer in phase III studies. Although disease control was achieved in 40% of the pretreated patients with metastatic colorectal cancer in the pivotal studies, radiological response has rarely been reported. Severe adverse events associated with regorafenib are known to occur during the first and second courses of treatment. We present a case of a 62-year-old Japanese patient whose metastatic colorectal cancer has been responding to treatment with regorafenib for 2 years...
August 18, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28815678/cutaneous-iridophoroma-in-a-green-iguana-%C3%A2-%C3%A2-%C3%A2-%C3%A2-%C3%A2-%C3%A2-%C3%A2-%C3%A2-%C3%A2-%C3%A2-%C3%A2-%C3%A2-%C3%A2-iguana-iguana-%C3%A2-%C3%A2-%C3%A2-%C3%A2-%C3%A2-%C3%A2-%C3%A2-%C3%A2-%C3%A2-%C3%A2-%C3%A2-%C3%A2-%C3%A2-%C3%A2-%C3%A2-%C3%A2-%C3%A2-%C3%A2-%C3%A2-%C3%A2-%C3%A2-%C3%A2-%C3%A2-%C3%A2-%C3%A2-%C3%A2
#3
Estelle Rousselet, Carlos H De Mello Souza, James F X Wellehan, Ember D Epperson, Michael J Dark, Heather L Wamsley
An 11-year-old intact male Green iguana (Iguana iguana) was referred for treatment of a probable iridophoroma based on previous cytopathology. A periocular mass was present near the right medial canthus. Computed tomography did not show any sign of metastasis. Clinicopathologic abnormalities included lymphopenia and hyperproteinemia. Cytologic and histologic evaluations of the mass were consistent with iridophoroma. Complete surgical excision of the mass was not possible without removal of the orbit due to local tissue involvement...
August 16, 2017: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/28815668/primary-low-grade-neuroendocrine-carcinoma-of-the-skin-an-exceedingly-rare-entity
#4
Tiffany Y Chen, Annie O Morrison, Joe Susa, Clay J Cockerell
Low-grade neuroendocrine tumors (NET), also known as carcinoid tumor, commonly arise from the gastrointestinal and pulmonary tracts, but rarely occur in the skin. Cutaneous NET typically occurs as metastases or high grade primary lesions, called Merkel cell carcinoma. In the few cases described in literature, primary low-grade neuroendocrine carcinomas of the skin (LGNECS) are usually indolent cutaneous nodules, presenting on the head and trunk of elderly patients. LGNECS tumors are histologically similar to its counterparts arising in other anatomic locations...
August 16, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28803992/p-rex1-amplification-promotes-progression-of-cutaneous-melanoma-via-the-pak1-p38-mmp-2-pathway
#5
Jinhua Wang, Hajime Hirose, Guanhua Du, Kelly Chong, Eiji Kiyohara, Isaac P Witz, Dave S B Hoon
P-REX1 (PIP3-dependent Rac exchange factor-1) is a guanine nucleotide exchange factor that activates Rac by catalyzing exchange of GDP for GTP bound to Rac. Aberrant up-regulation of P-REX1 expression has a role in metastasis however, copy number (CN) and function of P-REX1 in cutaneous melanoma are unclear. To explore the role of P-REX1 in melanoma, SNP 6.0 and Exon 1.0 ST microarrays were assessed. There was a higher CN (2.82-fold change) of P-REX1 in melanoma cells than in melanocytes, and P-REX1 expression was significantly correlated with P-REX1 CN...
August 10, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28800027/economic-burden-of-advanced-melanoma-in-france-germany-and-the-uk-a-retrospective-observational-study-melanoma-burden-of-illness-study
#6
Florent Grange, Peter Mohr, Mark Harries, Rainer Ehness, Laure Benjamin, Obukohwo Siakpere, Janina Barth, Ceilidh Stapelkamp, Sylvie Pfersch, Lori D McLeod, James A Kaye, Sorrel Wolowacz, Ilias Kontoudis
The aim of this study was to estimate the cost-of-illness associated with completely resected stage IIIB/IIIC melanoma with macroscopic lymph node involvement, overall and by disease phase, in France, Germany and the UK. This retrospective observational study included patients aged older than or equal to 18 years first diagnosed with stage IIIB/IIIC cutaneous melanoma between 1 January 2009 and 31 December 2011. Data were obtained from medical records and a patient survey. Direct costs, indirect costs and patient out-of-pocket expenses were estimated in euros (&OV0556;) (and British pounds, £) by collecting resource use and multiplying by country-specific unit costs...
August 10, 2017: Melanoma Research
https://www.readbyqxmd.com/read/28796000/genomic-analysis-of-pigmented-epithelioid-melanocytomas-reveals-recurrent-alterations-in-prkar1a-and-prkca-genes
#7
Jarish N Cohen, Nancy M Joseph, Jeffrey P North, Courtney Onodera, Artur Zembowicz, Philip E LeBoit
Pigmented epithelioid melanocytoma (PEM) is a rare cutaneous melanocytic tumor first described as epithelioid blue nevus in patients with the Carney Complex (CC). PEM was among the first established examples of an intermediate class of melanocytic tumors, including atypical Spitz tumors, with frequent metastasis to lymph nodes but only rare extranodal spread. Sporadic and CC-associated PEM are essentially histologically indistinguishable. A subset of PEM shows loss of cytoplasmic expression of the protein kinase A regulatory subunit alpha (PRKAR1A), a tumor suppressor gene mutated in 70% of families with CC...
August 8, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28795016/malignant-pilomatricoma-in-a-dog-with-local-and-distant-metastases-treated-with-chemotherapy-and-bisphosphonates
#8
Elisabetta Treggiari, James W Elliott
A ten-year-old male neutered cross breed dog presented for evaluation of a mass associated with the left scapular bone, identified as a carcinoma. The dog had a malignant pilomatricoma removed from the left lateral thigh 6 months earlier. Histopathology review of the cutaneous and scapular mass identified the same tumour type, confirming metastatic disease; additional metastases to the inguinal lymph node, liver and lungs were identified. Chemotherapy resulted in partial responses/stable disease of very short duration...
2017: Open veterinary journal
https://www.readbyqxmd.com/read/28793868/clinical-and-laboratory-profiles-of-patients-with-early-spontaneous-healing-in-cutaneous-localized-leishmaniasis-a-historical-cohort-study
#9
Carla Oliveira-Ribeiro, Maria Inês Fernandes Pimentel, Raquel de Vasconcellos Carvalhaes Oliveira, Aline Fagundes, Maria de Fatima Madeira, Cintia Xavier Mello, Eliame Mouta-Confort, Claudia Maria Valete-Rosalino, Erica de Camargo Ferreira Vasconcellos, Marcelo Rosandiski Lyra, Leonardo Pereira Quintella, Liliane de Fatima Antonio, Armando Schubach, Fatima Conceição-Silva
BACKGROUND: Skin ulcers in American cutaneous leishmaniasis (ACL) may heal spontaneously after months/years. However, few cases may present quick heal even during diagnosis procedure (early spontaneous healing- ESH). The main objective of this study was to compare ESH patients with cases requiring specific treatment [non-ESH (NESH)]. METHODS: A historical cohort study of ACL patients (n = 445) were divided into 2 groups: ESH - spontaneously healed patients (n = 13; 2...
August 10, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28783927/a-case-of-primary-small-bowel-melanoma-diagnosed-by-single-balloon-enteroscopy
#10
Jun Young Shin, In Suh Park, Byoung Wook Bang, Hyung Kil Kim, Yong Woon Shin, Kye Sook Kwon
Although metastasis from cutaneous malignant melanoma to the small intestine is not uncommon, primary small bowel melanoma (SBM) is extremely rare. This case report describes a rare case of primary SBM, diagnosed by single-balloon enteroscopy. A 74-year-old man presented with recurrent melena. Upper endoscopy and colonoscopy were unremarkable. Abdominal computed tomography (CT) revealed an ileal mass with ileo-ileal intussusception. Subsequent single-balloon enteroscopy identified an ileal tumor, which was histologically diagnosed as melanoma...
July 2017: Clinical Endoscopy
https://www.readbyqxmd.com/read/28776385/sternal-cutaneous-metastasis-of-hilar-cholangiocarcinoma
#11
Antonio José Fernández López, María Encarnación Tamayo-Rodríguez, María Ángeles Paniza-Mendoza
Subcutaneous metastasis is a rare initial manifestation of visceral tumors, and represent advanced stages with poor prognosis. We report the case of a female patient with a subcutaneous nodule over the sternum, which was ultimately found to be a metastasis of hilar cholangiocarcinoma. Only 20 cases of subcutaneous metastasis from Klatskin tumors have been reported - a rare occurrence with poor survival rates.
August 4, 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/28776316/a-case-of-sigmoid-colon-adenocarcinoma-diagnosed-as-facial-cutaneous-metastasis-for-survival-after-operation-for-37%C3%A2-months
#12
Junji Ueda, Hiroshi Yoshida, Hiroshi Makino, Hiroshi Maruyama, Tadashi Yokoyama, Atsushi Hirakata, Hideyuki Takata, Natsuki Seki, Yuta Kikuchi, Eiji Uchida
Cutaneous metastasis of an internal malignancy is uncommon and is estimated to occur in 0.7-9% of patients with internal cancer including autopsy cases. We would like to report a case of long survival of sigmoid colon adenocarcinoma diagnosed as an instance of facial cutaneous metastasis. A 68-year-old male was admitted to our hospital for a tumor mass on the left side of his cheek. In his past history, acute myocardial infarction had occurred 2 years earlier. He also had chronic renal failure and chronic obstructive pulmonary disease...
August 3, 2017: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/28763337/folliculotropic-metastatic-melanoma-a-case-report-and-review-of-the-literature
#13
Elizabeth L McKinnon, Kelly L West, Russell A Ball, Nathan Wright, Raymond L Barnhill
Folliculotropic metastasis of cutaneous melanoma is rare, with only 5 published case reports in the English language literature since it was first described in 2009. We report a 41-year-old man with a primary cutaneous melanoma of the right upper preauricular region with metastatic spread to the parotid gland and pulmonary lymph nodes. Excision of the primary lesion was performed and immunotherapy was initiated. Sixteen months later, the patient presented with 2 new lesions of the left forehead and left neck...
September 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28763275/cytologic-comparison-of-the-percentage-of-mast-cells-in-lymph-node-aspirate-samples-from-clinically-normal-dogs-versus-dogs-with-allergic-dermatologic-disease-and-dogs-with-cutaneous-mast-cell-tumors
#14
Melanie L Mutz, Bonnie B Boudreaux, Angela Royal, Sandra Merchant, Cherie Pucheu-Haston, Emily H Griffith, Tracy L Gieger
OBJECTIVE To compare percentages of mast cells in lymph node (LN) aspirate samples from clinically normal dogs, dogs with allergic dermatologic disease (ADD), and dogs with cutaneous mast cell tumors (MCTs). DESIGN Prospective cross-sectional study. ANIMALS 20 healthy dogs (group 1), 20 dogs with ADD (group 2), and 20 dogs with an MCT on the head or limbs (group 3). PROCEDURES LN aspirate samples were obtained from easily accessible LNs in group 1, affected skin regions in group 2, and the likely draining LN or LNs of the MCT in group 3; the percentage of mast cells was manually determined for each LN...
August 15, 2017: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/28761299/cutaneous-plasmacytoma-metastasis-of-multiple-myeloma-at-the-fracture-site
#15
Jisook Yoo, Mingyul Jo, Min-Soo Kim, Mihn-Sook Jue, Hyang-Joon Park, Kwang-Hyun Choi
Multiple myeloma (MM) can be defined as a malignancy with monoclonal plasma cell proliferation. A 66-year-old man presented with pruritic erythematous to purplish plaque grouped nodule with black pigmentations and purpura on the right forearm. The patient was diagnosed with MM about five years prior to the visit at our hospital. Erythematous plaque on his right arm grew rapidly in size over one month and appeared about seven months after the fracture surgery. Skin biopsy showed multiple plasma cell infiltration with monoclonality for lambda light chain, which was consistent with cutaneous plasmacytoma...
August 2017: Annals of Dermatology
https://www.readbyqxmd.com/read/28756123/lymphatic-vessel-density-and-vegf-c-expression-as-independent-predictors-of%C3%A2-melanoma-metastases
#16
Zorica Špirić, Živka Eri, Mirela Erić
INTRODUCTION: In many patients, the clinical behaviour of cutaneous melanoma is very difficult to predict by traditional histologic and clinical parameters. This study aimed to examine the role of quantitative parameters of tumour lymphangiogenesis and vascular endothelial growth factor (VEGF)-C in predicting metastatic risk in patients with cutaneous melanoma. METHODS: One hundred melanoma specimens were stained with lymphatic-specific antibody D2-40 and with anti-VEGF-C antibody...
July 8, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/28747229/vaginal-metastasis-as-the-initial-presentation-of-leiomyosarcoma-a-case-report
#17
Cecilia Villalaín-González, Álvaro Tejerizo-García, Patricia Lopez-Garcia, Gregorio López-González, Ma Reyes Oliver-Perez, Jesús S Jiménez-López
BACKGROUND: Uterine leiomyosarcomas are very rare and highly aggressive tumors that have a high rate of recurrence and poor prognosis, even when early diagnosed. Due to their relative rarity, there is limited research on optimal management strategies. CASE PRESENTATION: A 60-year-old woman with a history of an asymptomatic uterine leiomyoma presented in October 2015 with postmenopausal bleeding and a friable vaginal cyst that bled when palpated. A partial cystectomy was performed, and malignant-like cystic and solid components were identified...
July 26, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28743863/transcriptome-analysis-of-canine-cutaneous-melanoma-and-melanocytoma-reveals-a-modulation-of-genes-regulating-extracellular-matrix-metabolism-and-cell-cycle
#18
Chiara Brachelente, Katia Cappelli, Stefano Capomaccio, Ilaria Porcellato, Serenella Silvestri, Laura Bongiovanni, Raffaella De Maria, Andrea Verini Supplizi, Luca Mechelli, Monica Sforna
Interactions between tumor cells and tumor microenvironment are considered critical in carcinogenesis, tumor invasion and metastasis. To examine transcriptome changes and to explore the relationship with tumor microenvironment in canine cutaneous melanocytoma and melanoma, we extracted RNA from formalin-fixed, paraffin-embedded (FFPE) specimens and analyzed them by means of RNA-seq for transcriptional analysis. Melanocytoma and melanoma samples were compared to detect differential gene expressions and significant enriched pathways were explored to reveal functional relations between differentially expressed genes...
July 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28740547/down-regulated-mir-23a-contributes-to-the-metastasis-of-cutaneous-melanoma-by-promoting-autophagy
#19
Weinan Guo, Huina Wang, Yuqi Yang, Sen Guo, Weigang Zhang, Yu Liu, Xiuli Yi, Jingjing Ma, Tao Zhao, Lin Liu, Zhe Jian, Ling Liu, Gang Wang, Tianwen Gao, Qiong Shi, Chunying Li
Melanoma is among the most aggressive tumors, and the occurrence of metastasis leads to a precipitous drop in the patients' survival. Therefore, identification of metastasis-associated biomarkers and therapeutic targets will contribute a lot to improving melanoma theranostics. Recently, microRNAs (miRNAs) have been implicated in modulating cancer invasion and metastasis, and are proved as potential non-invasive biomarkers in sera for various tumors. Here, we reported miR-23a as a novel metastasis-associated miRNA that played a remarkable role in modulating melanoma invasive and metastatic capacity and was of great value in predicting melanoma metastasis and prognosis...
2017: Theranostics
https://www.readbyqxmd.com/read/28739713/feasibility-of-postoperative-radiotherapy-using-conventional-fractionation-for-lymph-node-metastasis-from-cutaneous-melanoma
#20
Yeon Joo Kim, Si Yeol Song, Wanlim Kim, Seong-Yun Jeong, Wonsik Choi, Hyoung Uk Je, Jong-Seok Lee, Eun Kyung Choi
AIM: In the present study we assessed if postoperative radiotherapy (PORT) using conventional fractionation confers a benefit in cutaneous melanoma patients with lymph node (LN) metastasis. PATIENTS AND METHODS: Sixty-two patients with axillary or inguinal LN metastasis were retrospectively reviewed. Twenty-eight patients received PORT. The median RT dose was 50 Gy in 25 fractions. The high-risk group was defined by the presence of any of the following: ≥3 LNs, size ≥3 cm, extranodal extension...
August 2017: Anticancer Research
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