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https://www.readbyqxmd.com/read/29449046/-chordoma-cutis-an-unusual-clinical-presentation-of-a-rare-neoplasm-chordoma
#1
Clémence Delteil, Nausicaa Malissen, Romain Appay, Quentin Magis, Sébastien Aubert, Corinne Bouvier, Marie-Aleth Richard, Nicolas Macagno
Chordoma cutis represents an unusual clinical presentation of a rare neoplasm. The involvement of skin or sub-cutaneous soft tissues can be the consequence of local infiltration or metastasis; the latter may occur several years following the initial diagnosis of chordoma and therefore, may pose a diagnosis challenge when the clinical history of the patient is unknown. The clinical forms, morphology, immuno-histochemical profile and the main differential diagnoses of chordoma cutis are presented here through an anatomoclinical case...
February 12, 2018: Annales de Pathologie
https://www.readbyqxmd.com/read/29447644/cutaneous-metastasis-to-the-scalp-as-the-primary-presentation-of-colorectal-adenocarcinoma
#2
Sarita R Shah, Danielle S Applebaum, Silvia Potenziani, Yve T Huttenbach, John Wolf, Ida F Orengo
Eruptaneous metastasis is an uncommon presentation of colorectal adenocarcinoma that can occur years after diagnosis of the primary cancer or manifest as the first sign of malignancy. It is essential to diagnose these metastases immediately, as this late-stage development carries a poor prognosis. The scalp is one of the less common sites for skin metastases and nodules may be mistaken for benign entities. In this case report, we report on the case of a 61-year-old woman with CREST syndrome who presented with a cutaneous metastasis to the scalp as the first sign ofcolorectal adenocarcinoma...
November 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29441982/microrna-17-3p-promotes-keratinocyte-cells-growth-and-metastasis-via-targeting-myot-and-regulating-notch1-nf-%C3%AE%C2%BAb-pathways
#3
Hongshan Yan, Kunxiu Song, Guohui Zhang
Wound healing is a fundamental biological process to restore skin integrity. The role of microRNAs (miRNAs) during this process remains elusive. Thus, our study aimed to investigate the biological functions and its molecular mechanisms of miR-17-3p in cutaneous wound healing. Human keratinocyte cell line HaCaT was transfected with miR-17-3p mimic, antisense oligonucleotides (ASO)-miR-17-3p and corresponding controls respectively. After transfection, MTT, flow cytometry, qRT-PCR and western blot were performed to analyze cell viability, colony-formation and cell cycle...
September 1, 2017: Die Pharmazie
https://www.readbyqxmd.com/read/29438169/superficial-solitary-fibrous-tumor-a-series-of-26-cases
#4
Patrick Feasel, Alyaa Al-Ibraheemi, Karen Fritchie, Riyam T Zriek, Wei-Lien Wang, Elizabeth Demicco, Marcela Saeb-Lima, John R Goldblum, Brian P Rubin, Jesse K McKenney, Jennifer S Ko, Steven D Billings
While superficial (cutaneous/subcutaneous) solitary fibrous tumor (SFT) have been described, definitive diagnosis is difficult due to overlapping features with other tumors. We describe the largest series to date of superficial SFT. For inclusion, SFT had to arise in dermis or subcutis. Twenty-six cases were identified. Patients ranged from 16 to 80 years (mean, 47 y) with a marked female predominance (19 F; 7 M). Tumors involved the head (11), thigh (7), back (3), shoulder (2), upper arm (1), ankle (1), and great toe (1)...
February 12, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29433557/metastatic-uveal-melanoma-showing-durable-response-to-anti-ctla-4-and-anti-pd-1-combination-therapy-after-experiencing-progression-on-anti-pd-1-therapy-alone
#5
Muhammad Zubair Afzal, Rodwell Mabaera, Keisuke Shirai
BACKGROUND: Uveal melanoma accounts for 85% of the ocular melanomas and has an increased risk of hematogenous spread, most commonly to the liver. After curative intent therapy like surgery and radiation, fifty percent of patients present with distant metastasis. Metastatic uveal melanoma (MUM) does not harbor typically targetable mutations, e.g., BRAF as in cutaneous melanoma. As a result, there is no proven therapy for MUM. Various chemotherapy and immunotherapy regimens have been tried and only partial response (PR) is the best that has been achieved in most of the cases...
February 12, 2018: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/29431200/gata-3-staining-in-primary-cutaneous-apocrine-cribriform-carcinoma-usefulness-to-differentiate-it-from-breast-cancer-metastasis
#6
M Llamas-Velasco, Y C Pérez-Gónzalez, E Daudén, A Rütten
BACKGROUND: Primary cutaneous apocrine cribriform carcinoma (PCACC) is a rare tumor, clinically appearing as a solitary nodule, mostly involving extremities of females and this lesion usually raise a differential diagnosis with metastatic cribriform carcinomas, especially breast cancer. DESIGN: To study GATA3 expression in a series of 14 primary cutaneous cribriform carcinomas and to test this immunostaining usefulness to differentiate this tumor from metastatic breast cancer...
February 12, 2018: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29423164/cutaneous-metastasis-of-a-primary-oesophageal-adenocarcinoma-to-the-right-cheek
#7
Emily Higgins, Liam Monaghan, Raghu R Mani
This case report details of a case of cutaneous metastasis from a primary adenocarcinoma of the oesophagus to the right cheek. A 67-year-old male was referred to the maxillofacial department with a 2-3 week history of non-painful swelling of the cheek. A diagnosis of infected sebaceous cyst was made and drainage was attempted with adjunctive antibiotic therapy. Follow up appointments showed no improvement a biopsy was taken. Histology reported presence of metastatic adenocarcinoma, suggesting the gastrointestinal tract as the primary site...
September 2017: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/29422843/cutaneous-metastases-from-salivary-duct-carcinoma-of-the-submandibular-gland
#8
Wahida Chakari, Luise Andersen, Jørgen Lock Andersen
Salivary duct carcinoma is a rare and highly aggressive malignant neoplasm that frequently metastasises to other organs, but cutaneous metastasis is uncommon. There are only 6 cases reported in the literature with metastases to the skin and in all cases the tumour originates from the parotid gland. We present a case of skin metastases from the submandibular gland that was mistaken for basal cell carcinoma. To the best of our knowledge, this is the first reported case of salivary duct carcinoma arising from the submandibular gland with cutaneous metastases...
September 2017: Case Reports in Dermatology
https://www.readbyqxmd.com/read/29419901/cytokeratin-19-expression-is-a-risk-factor-for-metastasis-in-cutaneous-squamous-cell-carcinoma
#9
J Kato, T Hida, S Sugita, T Hasegawa, S Kamiya, K Horimoto, S Sato, M Sawada, H Uhara
Cytokeratin 19 (CK19) expression has been reported to be a risk factor for metastasis in oral squamous cell carcinoma. However, the significance of CK19 expression in cutaneous squamous cell carcinoma (cSCC) is unclear. Although some studies have reported CK19 expression in cSCC, no study has focused on the relationship between CK19 expression and metastasis in cSCC. Herein, we evaluate whether CK19 expression is related to metastasis in cSCC. This article is protected by copyright. All rights reserved.
February 8, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29415335/high-density-of-m2-macrophages-in-acral-lentiginous-melanoma-compared-to-superficial-spreading-melanoma
#10
M Zúñiga-Castillo, N V Pereira, M N Sotto
AIMS: Acral lentiginous melanoma (ALM) is the most common type of melanoma in people with darker skin phototypes. There is some evidences that the etiology, pathogenesis, risk factors, and natural history of ALM differ from those of superficial spreading melanoma (SSM). ALM behaves more aggressively than SSM, but the biological explanation for these differences remains unknown. The presence of one subtype of macrophages, termed M2-macrophage (M2-M), has been found to be related to local progression, metastasis, and poor prognosis in several neoplasms...
February 7, 2018: Histopathology
https://www.readbyqxmd.com/read/29405246/metastasis-risk-of-cutaneous-squamous-cell-carcinoma-in-organ-transplant-recipients-and-immunocompetent-patients
#11
Roel E Genders, Joris A J Osinga, Elise E Tromp, Peter O'Rourke, Jan N Bouwes Bavinck, Elsemieke I Plasmeijer
Organ transplant recipients (OTRs) have a high incidence of cutaneous squamous cell carcinoma (cSCC), and immunosuppression has been reported to be an important risk factor for metastasis. The aim of this study was to identify the metastasis risk over a 10-year period for 593 patients with cSCC, of whom 134 were OTR and 459 were immunocompetent. Metastasis incidence rate was 1,046 (95% confidence interval (95% CI) 524-2,096) per 100,000 person years in OTR and 656 (95% CI; 388-1,107) in immunocompetent patients, yielding an incidence rate ratio of 1...
February 6, 2018: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/29405038/systemic-treatments-for-metastatic-cutaneous-melanoma
#12
REVIEW
Sandro Pasquali, Andreas V Hadjinicolaou, Vanna Chiarion Sileni, Carlo Riccardo Rossi, Simone Mocellin
BACKGROUND: The prognosis of people with metastatic cutaneous melanoma, a skin cancer, is generally poor. Recently, new classes of drugs (e.g. immune checkpoint inhibitors and small-molecule targeted drugs) have significantly improved patient prognosis, which has drastically changed the landscape of melanoma therapeutic management. This is an update of a Cochrane Review published in 2000. OBJECTIVES: To assess the beneficial and harmful effects of systemic treatments for metastatic cutaneous melanoma...
February 6, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29402264/performance-of-a-prognostic-31-gene-expression-profile-in-an-independent-cohort-of-523-cutaneous-melanoma-patients
#13
Jonathan S Zager, Brian R Gastman, Sancy Leachman, Rene C Gonzalez, Martin D Fleming, Laura K Ferris, Jonhan Ho, Alexander R Miller, Robert W Cook, Kyle R Covington, Kristen Meldi-Plasseraud, Brooke Middlebrook, Lewis H Kaminester, Anthony Greisinger, Sarah I Estrada, David M Pariser, Lee D Cranmer, Jane L Messina, John T Vetto, Jeffrey D Wayne, Keith A Delman, David H Lawson, Pedram Gerami
BACKGROUND: The heterogeneous behavior of patients with melanoma makes prognostication challenging. To address this, a gene expression profile (GEP) test to predict metastatic risk was previously developed. This study evaluates the GEP's prognostic accuracy in an independent cohort of cutaneous melanoma patients. METHODS: This multi-center study analyzed primary melanoma tumors from 523 patients, using the GEP to classify patients as Class 1 (low risk) and Class 2 (high risk)...
February 5, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29394645/-a-case-of-long-term-survival-of-cutaneous-metastasis-from-primary-gastric-cancer
#14
Junya Morita, Toru Aoyama, Shinya Amano, Yukio Maezawa, Sho Sawazaki, Masakatsu Numata, Tsutomu Sato, Takashi Oshima, Takanobu Yamada, Tsutomu Hayashi, Shouji Yamanaka, Norio Yukawa, Yasushi Rino, Munetaka Masuda
A 65-year-old female received distal gastrectomy for gastric cancer.The pathological diagnosis was well differentiated adenocarcinoma(tub1), type 2, pT3, ly: 1, v: 1, N0, H0, P0, M0, CY0, pStage II A.She had been observed without adjuvant chemotherapy.Five years after the resection, umbilical tumor and intraperitoneal nodules were detected by computed tomography. Needle biopsy cytology of umbilical tumor revealed metastasis from gastric cancer.Based on the diagnosis of umbilical metastasis and peritoneal dissemination, S-1(80mg/m / 2, day 1-21)and CDDP(60mg/m2, day 8)were administered for 7 courses...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29391911/evaluation-of-18f-fdg-pet-ct-parameters-for-detection-of-lymph-node-metastasis-in-cutaneous-melanoma
#15
Jongtae Cha, Soyoung Kim, Jiyoung Wang, Mijin Yun, Arthur Cho
Purpose: The purpose of this study was to investigate the value of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) parameters in the detection of regional lymph node (LN) metastasis in patients with cutaneous melanoma. Methods: We evaluated patients with cutaneous melanoma who underwent FDG PET/CT for initial staging or recurrence evaluation. A total of 103 patients were enrolled, and 165 LNs were evaluated. LNs that were confirmed pathologically or by follow-up imaging were included in this study...
February 2018: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29390545/rare-upper-gastrointestinal-hemorrhage-of-cetuximab-a-case-report
#16
Shi-Jie Duan, Zi-Ming Gao, Peng-Liang Wang, Bao-Cheng Gong, Han-Wei Huang, Lei Luo, Xin Wang, Ya-Nan Xing, Hui-Mian Xu, Fu-Nan Liu
RATIONALE: cetuximab, an epidermal growth factor receptor inhibitor, is a targeted therapeutic regimen of colorectal cancers. Several common adverse effects have been found, such as cutaneous or gastrointestinal toxicity. However, according to the articles had been published, upper gastrointestinal bleeding (UGIB) is considered to be rare and its mechanism remains unclear. PATIENT CONCERNS: In this report, we presented a 42-year-old male patient with advanced recto-sigmoid cancer...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29387004/pazopanib-induced-cutaneous-leukocytoclastic-vasculitis-an-exclusion-diagnosis-of-a-multidisciplinary-approach
#17
Diogo Alpuim Costa, Susana Baptista de Almeida, Pedro Coelho Barata, António Quintela, Pedro Cabral, Ana Afonso, João Maia Silva
In phase II/III trials, cutaneous side effects of pazopanib were reported in less than 20% of patients, with only 1-3% being grade 3/4. We present a case of a 66-year-old man with a previous history of left nephrectomy for a stage II clear cell renal carcinoma. Approximately 18 months later, recurrent disease in the lungs, mediastinum, and left psoas and bulky abdominal/pelvic nodal metastasis were documented. He was initially treated with pazopanib 800 mg q.d. and 1 week after starting this therapy, the patient presented with palpable purpura on his ankles...
September 2017: Case Reports in Oncology
https://www.readbyqxmd.com/read/29362629/primary-solitary-melanoma-of-the-lymphatic-nodes-or-a-single-metastasis-of-unknown-melanoma-do-we-need-a-new-staging-system
#18
Georgi Tchernev, Anastasiya Chokoeva, Lyubomira Victor Popova
BACKGROUND: Malignant melanoma is a disease which has a cutaneous origin in 90% of the patients, but in rare cases, it could be discovered as secondary deposits with unknown primary site. Metastatic Malignant Melanoma occurs without a primary site in about 3% of all melanoma patients, and it could be divided into two main groups: metastatic lymph nodes' involvement or non-lymph nodes disease. The lack of unified classification and staging system, provided by AJCC (2009), as well as the lack for curtain diagnostic and therapeutic protocol, prompt us to raise the question what is the right way to precede in cases of metastasis of the lymph nodes, without evidence of a primary tumour? CASE REPORT: We report a case of 67-years- old woman who presented in the dermatology clinic after a surgical removal of an enlarged lymph node in her left femoral area, verified histologically as a metastasis of melanoma...
December 15, 2017: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29362627/pet-scan-misses-cutaneous-melanoma-metastasis-with-significant-tumour-size-and-tumour-thickness
#19
Georgi Tchernev, Liubomira Victor Popova
BACKGROUND: Although PET-scan is an advanced, innovative and widely used method for monitoring patients with different types of cancer diseases, it is important to note that its application in patients with cutaneous melanoma is limited and should be reconsidered. CASE REPORT: To affirm this new statement, we are presenting a case from our clinical practice of a patient with melanoma of the interdigital space (with resected in sano primary melanoma and performed complete lymphadenectomy) that showed locoregional and systemic progression in two months post operation...
December 15, 2017: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29362221/ccl20-expression-by-tumor-associated-macrophages-predicts-progression-of-human-primary-cutaneous-melanoma
#20
Rafael Samaniego, Alejandra Gutierrez-Gonzalez, Alba Gutierrez-Seijo, Sandra Sanchez-Gregorio, Jorge García-Gimenez, Enrique Mercader, Ivan Marquez-Rodas, Jose Antonio Aviles, Miguel Relloso, Paloma Sanchez-Mateos
The chemokine axis CCR6/CCL20 is involved in cancer progression in a variety of tumors. Here we show that CCR6 is expressed by melanoma cells. The CCR6 ligand, CCL20, induces migration and proliferation in vitro, and enhances tumor growth and metastasis in vivo. Confocal analysis of melanoma tissues showed that CCR6 is expressed by tumor cells, whereas CCL20 is preferentially expressed by non-tumoral cells in the stroma of certain tumors. Stromal CCL20, but not tumoral CCR6, predicted poor survival in a cohort of 40 primary melanoma patients...
January 23, 2018: Cancer Immunology Research
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