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https://www.readbyqxmd.com/read/29674402/cutaneous-lymphangitis-carcinomatosa-made-cervicofacial-oedema-intractable-in-a-patient-with-superior-vena-cava-syndrome
#1
Eriko Kashihara, Osamu Kanai, Misato Okamura, Tadashi Mio
Cutaneous lymphangitis carcinomatosa (CLC) is a rare form of cutaneous metastasis that causes lymphoedema and various eruptions. We report a case of lung cancer with CLC that caused both superior vena cava (SVC) stenosis and cervicofacial oedema, suggestive of SVC syndrome. A 64-year-old woman with lung adenocarcinoma presented with cervicofacial oedema and erythema, followed by severe dyspnoea 2 months after four cycles of carboplatin, pemetrexed and bevacizumab triplet therapy. Although chest CT indicated SVC stenosis, cervicofacial oedema remained despite treating the SVC stenosis via balloon dilation...
April 19, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29674005/breast-cancer-cutaneous-metastases-mimicking-papilloma-cutis-lymphostatica-biopsy-to-avoid-pitfalls
#2
Giuseppe Giudice, Michelangelo Vestita, Fabio Robusto, Paolo Annoscia, Francesco Ciancio, Eleonora Nacchiero
INTRODUCTION: Secondary lymphedema is the most frequent long-term complication of axillary lymphadenectomy. It can result in complication as erysipelas, warts, Papilloma Cutis Lymphostatica (PCL), or angiosarcomas. Moreover, in women affected by breast cancer an accurate differential diagnosis among these conditions or complication related to radiation dermatitis or cutaneous metastasis is essential. PRESENTATION OF CASE: We report the case of a 60-year-old postmenopausal Caucasian woman affected by secondary lymphedema following complete mastectomy for breast cancer...
April 10, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29672360/cutaneous-metastasis-of-adenocarcinoma-of-the-ampulla-of-vater
#3
Angel Fernandez-Flores, David S Cassarino
Cutaneous metastases from an adenocarcinoma of the Ampulla of Vater are very rare, with only a few cases previously reported. We present here an additional case in a 57-year-old woman who complained of a painful growth on her frontal scalp that she had noticed 4 months earlier. Her medical history included an ampullary adenocarcinoma, which was diagnosed 4 years ago, excised through a Whipple procedure, and treated using chemotherapy and radiotherapy. The scalp biopsy showed a dermal and epidermotropic well-differentiated glandular neoplasm with abundant neutrophils within the luminae of the tumoral glands...
April 17, 2018: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29667930/kcnq1ot1-promotes-melanoma-growth-and-metastasis
#4
Bingyu Guo, Qian Zhang, Hongyi Wang, Peng Chang, Kai Tao
Melanoma is the deadliest cutaneous neoplasm. To prevent metastasis, early diagnosis and surgical treatment is vital. Long non-coding RNAs (lncRNAs) may serve as biomarkers and therapeutic targets in tumors. We investigated the molecular mechanisms of lncRNA KCNQ1OT1 in melanoma. Real time PCR demonstrated that KCNQ1OT1 expression is up-regulated in melanoma tissues and cells. KCNQ1OT1 promoted cell proliferation and metastasis in melanoma. By directly bindin to miR-153, KCNQ1OT1 acted as a competing endogenous RNA (ceRNA) to de-repress MET expression...
April 17, 2018: Aging
https://www.readbyqxmd.com/read/29665032/testicular-choriocarcinoma-with-cutaneous-metastasis-in-a-19-year-old-man
#5
Ferdinand Toberer, Alexander Enk, Wolfgang Hartschuh, Carsten Grüllich
A 19-year-old man suffering from testicular choriocarcinoma presented to the dermatology department with a cutaneous metastasis on his head. This metastasis was the first sign of disease that led to medical consultation. Histopathology revealed cytotrophoblasts and syncytiotrophoblasts, the later expressing human chorionic gonadotropin antigen. Whole body computed tomography showed multiple metastases of the brain, lung, liver, bone, paraaortic lymph nodes and left uvea, the primary was found in the left testicle...
April 17, 2018: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29660160/digital-image-analysis-improves-precision-of-programmed-death-ligand-1-pd-l1-scoring-in-cutaneous-melanoma
#6
Viktor H Koelzer, Aline Gisler, Jonathan C Hanhart, Johannes Griss, Stephan N Wagner, Niels Willi, Gieri Cathomas, Melanie Sachs, Werner Kempf, Daniela S Thommen, Kirsten D Mertz
AIMS: Immune checkpoint inhibitors have become a successful treatment in metastatic melanoma. The high response rates in a subset of patients suggest that a sensitive companion diagnostic test is required. The predictive value of programmed death ligand 1 (PD-L1) staining in melanoma has been questioned due to inconsistent correlation with clinical outcome. Whether this is due to predictive irrelevance of PD-L1 expression or inaccurate assessment techniques remains unclear. The aim of this study was to develop a standardized digital protocol for the assessment of PD-L1 staining in melanoma and to compare the output data and reproducibility to conventional assessment by expert pathologists...
April 16, 2018: Histopathology
https://www.readbyqxmd.com/read/29648676/sentinel-lymph-node-biopsy-in-cutaneous-squamous-cell-carcinoma-series-of-37-cases-and-systematic-review-of-the-literature
#7
Raphael Lhote, Jérôme Lambert, Jumie Lejeune, Jeremy Gottlieb, Antoine Badaoui, Maxime Battistella, Jennifer Roux, Cecile Pages, Laetitia Vercellino, Catherine Vilmer, Christine Le Maignan, Catherine Escande, Besma MBarek, Martine Bagot, Celeste Lebbé, Nicole Basset-Seguin
Cutaneous squamous cell carcinoma is one of the most common skin cancers and can lead to patient death. Early diagnosis of node metastasis is a major goal for dermatologists and oncologists. The sentinel lymph node procedure has been proposed to improve this issue but is still debated. To evaluate the efficacy and the impact of this technique on prognosis of cutaneous squamous cell carcinoma, 37 patients (Saint Louis Hospital, Paris - France) who underwent sentinel lymph node biopsy and 290 cases from the literature were analyzed...
April 12, 2018: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/29643717/penile-and-multiple-cutaneous-metastases-over-the-pubic-region-from-a-rectal-adenocarcinoma-an-uncommon-case
#8
Vipul D Yagnik
Synchronous penile and multiple cutaneous metastases over the pubic region from a rectal adenocarcinoma are rare, and they usually indicate widespread disease. The most frequent localization of cutaneous metastases is the postoperative scar. Simultaneous penile and pubic region metastases are extremely uncommon. Although a penile metastasis from a rectal adenocarcinoma has been reported, synchronous metastases over the penile and pubic area have not been reported previously. We present a case of penile and multiple cutaneous metastases over the pubic region from a rectal adenocarcinoma along with a brief review of the literature...
January 2018: Ci Ji Yi Xue za Zhi, Tzu-chi Medical Journal
https://www.readbyqxmd.com/read/29629337/novel-therapeutic-targets-in-cutaneous-squamous-cell-carcinoma
#9
REVIEW
Teruki Yanagi, Shinya Kitamura, Hiroo Hata
Cutaneous squamous cell carcinoma (SCC) is one of the common cancers in Caucasians, accounting for 20-30% of cutaneous malignancies. The risk of metastasis is low in most patients; however, aggressive SCC is associated with very high mortality and morbidity. Although cutaneous SCC can be treated with surgical removal, radiation and chemotherapy singly or in combination, the prognosis of patients with metastatic SCC is poor. Recently, the usage of immune checkpoint blockades has come under consideration. To develop effective therapies that are less toxic than existing ones, it is crucial to achieve a detailed characterization of the molecular mechanisms that are involved in cutaneous SCC pathogenesis and to identify new drug targets...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29625783/unexpected-breast-metastasis-from-cutaneous-melanoma-on-18-f-fdg-pet-ct
#10
N Martínez-Amador, I Martínez-Rodríguez, A García-Castaño, J Jiménez-Bonilla, R Quirce, I Banzo
No abstract text is available yet for this article.
April 3, 2018: Revista Española de Medicina Nuclear e Imagen Molecular
https://www.readbyqxmd.com/read/29614021/non-metastatic-cutaneous-melanoma-induces-chronodisruption-in-central-and-peripheral-circadian-clocks
#11
Leonardo Vinícius Monteiro de Assis, Maria Nathália Moraes, Keila Karoline Magalhães-Marques, Gabriela Sarti Kinker, Sanseray da Silveira Cruz-Machado, Ana Maria de Lauro Castrucci
The biological clock has received increasing interest due to its key role in regulating body homeostasis in a time-dependent manner. Cancer development and progression has been linked to a disrupted molecular clock; however, in melanoma, the role of the biological clock is largely unknown. We investigated the effects of the tumor on its micro- (TME) and macro-environments (TMaE) in a non-metastatic melanoma model. C57BL/6J mice were inoculated with murine B16-F10 melanoma cells and 2 weeks later the animals were euthanized every 6 h during 24 h...
April 3, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29601841/intratumoral-and-peritumoral-lymphovascular-invasion-detected-by-d2-40-immunohistochemistry-correlates-with-metastasis-in-primary-cutaneous-merkel-cell-carcinoma
#12
Rami N Al-Rohil, Denái R Milton, Priyadharsini Nagarajan, Jonathan L Curry, Laurence Feldmeyer, Carlos A Torres-Cabala, Doina Ivan, Victor G Prieto, Michael T Tetzlaff, Phyu P Aung
Primary cutaneous Merkel cell carcinoma (MCC) is an aggressive neuroendocrine malignancy in which lymphovascular invasion (LVI) correlates with more aggressive phenotype. The prognostic significance of LVI detected by D2-40 immunohistochemistry (IHC) in MCC remains controversial. We aimed to determine how LVI detected by D2-40 IHC compares with LVI detected by hematoxylin-eosin (H&E) staining in predicting MCC metastasis. Clinical and histopathologic features of MCCs diagnosed and treated during 2002-2015 were assembled and included 58 MCC tumors from 58 patients...
March 27, 2018: Human Pathology
https://www.readbyqxmd.com/read/29595571/targeted-ultrasound-and-fine-needle-aspiration-cytology-for-sentinel-node-diagnostics-in-early-stage-melanoma-a-validation-study
#13
Niels K Ternov, Trine-Lise Lambine, Anne L H Wagenblast, Erik Clasen-Linde, Peter S Oturai, Helle Klyver, Kristina R Nielsen, Michael B Nielsen, Krzysztof T Drzewiecki, Annette H Chakera
Ultrasound-guided fine-needle aspiration cytology (US-FNAC) is used to evaluate the involvement of lymph nodes in various malignant diseases. Its value in detecting sentinel lymph node (SN) metastasis preoperatively in melanoma patients is controversial and is the subject of this study. In this prospective validation study, 91 consecutive patients with melanoma clinical stage I (n=64) and II (n=27) were examined with US-FNAC before SN biopsy from 2012 to 2014 at a tertiary center. All patients underwent lymphoscintigraphy before the US-FNAC...
March 27, 2018: Melanoma Research
https://www.readbyqxmd.com/read/29578151/mir-186-inhibits-cell-proliferation-and-invasion-in-human-cutaneous-malignant-melanoma
#14
Bei-Bei Su, Shu-Wei Zhou, Cai-Bin Gan, Xiao-Ning Zhang
Aims: MicroRNA-186 (miR-186) has been shown to be involved in various types of cancer. The purpose of this study was to investigate the expression level and functional role of miR-186 in human cutaneous malignant melanoma cells. Subjects and Methods: Expression of miR-186 was analyzed in human cutaneous malignant melanoma (CMM) cell lines SK-MEL-1, G-361, A375 and A875, and human normal epidermal melanocytes cell line HEMn-LP by quantitative reverse transcription polymerase chain reaction (qRT-PCR)...
2018: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/29562758/skin-metastasis-as-the-first-manifestation-of-lung-carcinoma
#15
Ali Koyuncuer, Sedat Suat Cüzdan, Eyüp Şenköy, Nesip Kalacı
Lung cancer is the most frequently diagnosed non-skin cancer and has a high mortality rate. Skin metastases that manifest as visceral malignancies are rare. Cutaneous metastasis from lung cancer has been observed in only 0.22%-12% of cases and is rarely the first manifestation of lung cancer. The histopathological features of metastases are occasionally difficult to distinguish from those of primary cutaneous tumors, despite the rigorous application of useful techniques, particularly immunohistochemistry. We report 3 asymptomatic cases of men who presented with solitary periumbilical, sacral, and scalp metastasis as the first manifestation of an underlying malignant lung tumor...
January 1, 2018: Asian Cardiovascular & Thoracic Annals
https://www.readbyqxmd.com/read/29559732/nf1-mutations-in-conjunctival-melanoma
#16
S L Scholz, I Cosgarea, D Süßkind, R Murali, I Möller, H Reis, S Leonardelli, B Schilling, T Schimming, E Hadaschik, C Franklin, A Paschen, A Sucker, K P Steuhl, D Schadendorf, H Westekemper, K G Griewank
BACKGROUND: Conjunctival melanoma is a potentially deadly eye tumour. Despite effective local therapies, tumour recurrence and metastasis remain frequent. The genetics of conjunctival melanomas remain incompletely understood. METHODS: A large cohort of 63 conjunctival melanomas was screened for gene mutations known to be important in other melanoma subtypes by targeted next-generation sequencing. Mutation status was correlated with patient prognosis. RESULTS: Frequent mutations in genes activating the MAP kinase pathway were identified...
March 21, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29555579/analysis-of-cancer-associated-fibroblasts-and-the-epithelial-mesenchymal-transition-in-cutaneous-basal-cell-carcinoma-squamous-cell-carcinoma-and-malignant-melanoma
#17
Kousuke Sasaki, Tamotsu Sugai, Kazuyuki Ishida, Mitsumasa Osakabe, Hiroo Amano, Hiroaki Kimura, Minoru Sakuraba, Katsuhiko Kashiwa, Seiichiro Kobayashi
Activated cancer-associated fibroblasts (CAFs) and fibroblasts that have undergone the epithelial-mesenchymal transition (EMT) in cancer stroma contribute to tumor progression and metastasis. However, no reports have investigated the CAF phenotype and its clinicopathological relevance in cutaneous malignant tumors, including basal cell carcinoma (BCC), squamous cell carcinoma (SCC) and malignant melanoma (MM). Here, we investigated the CAF phenotype in cutaneous malignant tumors based on their histology and immunohistochemical expression of CAF-related markers, including adipocyte enhancer-binding protein 1 (AEBP1), podoplanin, platelet derived growth factor receptor α (PDGFRα), PDGFRβ, fibroblast activating protein (FAP), CD10, S100A4, α-smooth muscle actin (α-SMA), and EMT-related markers (Zeb1, Slug and Twist)...
March 16, 2018: Human Pathology
https://www.readbyqxmd.com/read/29552728/sentinel-lymph-node-biopsy-in-cutaneous-head-and-neck-melanoma
#18
D Evrard, E Routier, C Mateus, G Tomasic, J Lombroso, F Kolb, C Robert, A Moya-Plana
PURPOSE: Sentinel lymph node biopsy (SLNB) is now a standard of care for cutaneous melanoma, but it is still controversial for cutaneous head and neck melanoma (CHNM). This study aims to confirm the feasibility, accuracy and low morbidity of SLNB in CHNM and evaluate its prognostic value. METHODS: A monocentric and retrospective study on patients with CHNM treated in our tertiary care center (Gustave Roussy) between January 2008 and December 2012 was performed. The feasibility, morbidity and prognostic value of this technique were analysed...
March 19, 2018: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29552543/cutaneous-angiosarcoma-the-possibility-of-new-treatment-options-especially-for-patients-with-large-primary-tumor
#19
REVIEW
Yasuhiro Fujisawa, Koji Yoshino, Taku Fujimura, Yoshiyuki Nakamura, Naoko Okiyama, Yosuke Ishitsuka, Rei Watanabe, Manabu Fujimoto
The most widely accepted treatment for cutaneous angiosarcoma (CAS) is wide local excision and postoperative radiation to decrease the risk of recurrence. Positive surgical margins and large tumors (T2, >5 cm) are known to be associated with poor prognosis. Moreover, T2 tumors are known to be associated with positive surgical margins. According to previous reports, the majority of CAS patients in Japan had T2 tumors, whereas less than half of the patients in the studies from western countries did so. Consequently, the reported 5-year overall survival of Japanese CAS patients without distant metastasis was only 9%, lower than that for stage-IV melanoma...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29549898/sentinel-lymph-node-biopsy-in-merkel-cell-carcinoma-the-mayo-clinic-experience-of-150-patients
#20
John R Sims, Travis E Grotz, Barbara A Pockaj, Richard W Joseph, Robert L Foote, Clark C Otley, Amy L Weaver, James W Jakub, Daniel L Price
BACKGROUND: Merkel cell carcinoma (MCC) is a rare cutaneous malignancy of neuroendocrine origin with a high propensity for lymph node metastasis. Sentinel lymph node (SLN) status is important for accurate staging; however, the optimal treatment following SLN biopsy, regardless of nodal status, remains unclear. METHODS: 150 patients with MCC who underwent SLN biopsy from 1995 to 2011 at 3 Mayo Clinic sites were reviewed. RESULTS: Of 150 patients with MCC who underwent SLN biopsy, 39 (26%) were positive and 111 (74%) were negative...
March 2018: Surgical Oncology
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