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Non-small cell lung cancer surgery

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https://www.readbyqxmd.com/read/28340378/current-fda-approved-treatments-for-non-small-cell-lung-cancer-and-potential-biomarkers-for-its-detection
#1
REVIEW
Karla A Ruiz-Ceja, Yolanda I Chirino
BACKGROUND: Lung cancer is the leading worldwide cancer with almost 1.5 million deaths every year. Some drugs for lung cancer treatment have been available on the market for decades, but novel drugs have emerged promising better outcomes, especially for Non-Small Cell Lung Cancer (NSCLC), which represents 75% of lung cancer cases. However, how much do drugs have evolved for NSCLC treatment? Are they sharing the same mechanism of action? AIM: In this review we analyzed how the approved drugs by Federal Drug Agency for NSCLC have advanced in the last four decades identifying shared mechanism of action of medicines against NSCLC treatment and some of the potential biomarkers for early detection...
March 21, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28339761/combined-modality-therapy-in-stage-iiia-non-small-cell-lung-cancer-clarity-or-confusion-despite-the-highest-level-of-evidence
#2
Branislav Jeremic, Francesc Casas, Pavol Dubinsky, Antonio Gomez-Caamano, Nikola Cihoric, Gregory Videtic, Miroslav Latinovic
Recent years have witnessed a number of clinical trials in Stage IIIA non-small cell lung cancer (NSCLC) comparing (A) induction chemotherapy (CHT) with induction CHT and radiotherapy (RT), each followed by surgery; (B) either induction CHT or induction RT-CHT, each followed by surgery, with definitive RT-CHT (no surgery). Due to the heterogeneity of patient, tumor and treatment characteristics across these trials, various meta-analyses (MAs) have been performed to define the optimal treatment approach in this setting for this clinical presentation...
February 24, 2017: Journal of Radiation Research
https://www.readbyqxmd.com/read/28339045/identification-of-circulating-long-non-coding-rna%C3%A2-gas5-as-a-potential-biomarker-for-non-small-cell-lung-cancer-diagnosisnon-small-cell-lung-cancer-long-non-coding-rna-plasma-gas5-biomarker
#3
Qian Tan, Jiangcheng Zuo, Shili Qiu, Yalan Yu, Hu Zhou, Nandi Li, Hui Wang, Chunzi Liang, Mingxia Yu, Jiancheng Tu
Non-small cell lung cancer (NSCLC) is one of the most malignant cancers in the world. Early diagnosis of NSCLC has become especially important for patient treatment and prognosis. Increasing evidence suggest that long non-coding RNA GAS5 plays vital roles in cancer proliferation and differentiation in NSCLC. However, its clinical value in the diagnosis of NSCLC is unclear. The objective of this study was to evaluate the importance of circulating GAS5 as a biomarker for NSCLC diagnosis. In our study, quantitative real-time PCR (QRT-PCR) was applied to detect the GAS5 expression level in 80 pairs of cancer tissues and 57 pairs of plasma samples of NSCLC patients...
March 22, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28337370/role-of-epidermal-growth-factor-receptor-in-lung-cancer-and-targeted-therapies
#4
REVIEW
Tie-Cheng Liu, Xin Jin, Yan Wang, Ke Wang
Lung cancer is the foremost cause of cancer-related deaths world-wide. Both, the major forms of lung cancer, Non-small cell lung cancer (NSCLC) and Small cell lung cancers (SCLC), have responded effectively to chemo-, radiation and adjuvant-therapies. Tumor removal through surgery also appeared as a good therapeutic strategy. However, these therapies demonstrated unfavourable side-effects, and hence novel drugs targeting lung cancer emerged essential. Activation of epidermal growth factor receptor (EGFR)-tyrosine kinases is a key reason for lung cancer progression...
2017: American Journal of Cancer Research
https://www.readbyqxmd.com/read/28329255/resection-rate-and-operability-of-elderly-patients-with-non-small-cell-lung-cancer-nationwide-study-from-1991-to-2014
#5
Kristjan Baldvinsson, Gudrun Nina Oskarsdottir, Andri Wilberg Orrason, Hannes Halldorsson, Hunbogi Thorsteinsson, Martin Ingi Sigurdsson, Steinn Jonsson, Tomas Gudbjartsson
OBJECTIVES: An increasing number of elderly patients are diagnosed with non-small cell lung cancer (NSCLC). We compared the surgical resection rate, operability and survival in this age group (≥75 years) to younger patients using centralized databases in Iceland. METHODS: The study population comprised all patients diagnosed with NSCLC in Iceland from 1991 to 2014. A total of 140 elderly patients (≥75 years) with NSCLC underwent pulmonary resection and were compared with 550 surgically resected patients less than 75 years, with respect to resection rate, short and long-term survival and complications of surgery...
January 31, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28329143/epidermal-growth-factor-receptor-mutations-are-linked-to-skip-n2-lymph-node-metastasis-in-resected-non-small-cell-lung-cancer-adenocarcinomas%C3%A2
#6
Francesco Guerrera, Stéphane Renaud, Fabrizio Tabbó, Anne-Claire Voegeli', Pier Luigi Filosso, Michèle Legrain, Monica Boita, Mickaël Schaeffer, Michèle Beau-Faller, Enrico Ruffini, Pierre-Emmanuel Falcoz, Giorgio Inghirami, Alberto Oliaro, Gilbert Massard
OBJECTIVES: The impact of skip N2 metastases (i.e. N2 lymph node metastases without N1) on survival in surgically resected non-small lung cancer remains an intriguing and rarely investigated topic. The goal of our study was to elucidate (i) skip N2 influence on overall survival (OS) and time to recurrence (TTR) in patients with resected lung adenocarcinoma and (ii) its link with epidermal growth factor receptor ( EGFR ) and v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog ( KRAS ) mutations...
December 15, 2016: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28327923/heart-dose-exposure-as-prognostic-marker-after-radiotherapy-for-resectable-stage-iiia-b-non-small-cell-lung-cancer-secondary-analysis-of-a-randomised-trial
#7
M Guberina, W Eberhardt, M Stuschke, T Gauler, F Heinzelmann, D Cheufou, M Kimmich, G Friedel, H Schmidberger, K Darwiche, V Jendrossek, M Schuler, G Stamatis, C Pöttgen
BACKGROUND: Heart exposure to ionizing irradiation can cause ischemic heart disease. The partial heart volume receiving ≥5 Gy (heartV5) was supposed to be an independent prognostic factor for survival after radiochemotherapy for locally advanced non-small cell lung cancer (NSCLC). But validation of the latter hypothesis is needed under the concurrent risks of lung cancer patients. PATIENTS AND METHODS: The ESPATUE phase III trial recruited patients with potentially operable IIIA(N2)/selected IIIB NSCLC between 01/2004 and 01/2013...
February 21, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28325074/lobectomy-for-lung-cancer-by-video-assisted-thoracic-surgery-in-situs-inversus
#8
Abdillah N Juma, Yan-Qing Wang, Yun Chen, Xiong Peng, Yuan Zhou, Wei Zhuang
A 62-year-old man with situs inversus totalis and non-small-cell lung cancer underwent a right lower lobectomy by video-assisted thoracoscopic surgery. Lobectomy in a situs inversus totalis patient can be performed safely using this minimally invasive procedure. Preoperative evaluation of the pulmonary artery and veins by three-dimensional computed tomography and the bronchial tree by bronchoscopy, is essential to avoid unanticipated complications during the procedure.
March 2017: Asian Cardiovascular & Thoracic Annals
https://www.readbyqxmd.com/read/28303059/marginal-pulmonary-function-is-associated-with-poor-short-and-long-term-outcomes-in-lung-cancer-surgery
#9
Naoki Ozeki, Koji Kawaguchi, Toshiki Okasaka, Takayuki Fukui, Koichi Fukumoto, Shota Nakamura, Shuhei Hakiri, Kohei Yokoi
We sought to determine the short- and long-term prognoses among 'marginal-risk' non-small cell lung cancer patients who have a predicted postoperative- (ppo) forced expiratory volume in the first second (FEV1) of 30-60% and/or a ppo-diffusing capacity of the lung for carbon monoxide (DLCO) of 30-60%. The present study included 73 'marginal-risk' and 318 'normal-risk' patients who underwent anatomical resection for clinical stage I lung cancer between 2008 and 2012. The rates of postoperative morbidity, prolonged hospital stay, and overall survival were assessed...
February 2017: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/28302437/definitive-radiotherapy-for-local-recurrence-of-nsclc-after-surgery
#10
Abraham J Wu, Elizabeth Garay, Amanda Foster, Meier Hsu, Zhigang Zhang, Jamie E Chaft, James Huang, Kenneth E Rosenzweig, Andreas Rimner
INTRODUCTION: Locoregional recurrence after resection of non-small-cell lung cancer (NSCLC) is common. We examined outcomes after definitive radiotherapy (RT) to identify prognostic factors for survival and further recurrence. PATIENTS AND METHODS: We reviewed 152 patients who received RT for locoregional recurrent (LR)-NSCLC, and analyzed subsequent overall survival (OS), locoregional failure (LRF), distant metastasis (DM), and any disease progression (LRF and DM)...
February 21, 2017: Clinical Lung Cancer
https://www.readbyqxmd.com/read/28301349/influence-of-extent-of-lymph-node-evaluation-on-survival-for-pathologically-lymph-node-negative-non-small-cell-lung-cancer
#11
Daniel J Becker, Benjamin P Levy, Heather T Gold, Scott E Sherman, Danil V Makarov, David Schreiber, Juan P Wisnivesky, Harvey I Pass
OBJECTIVES: Despite previous retrospective reports that the number of lymph nodes resected at curative intent surgery for lung cancer correlates with overall survival (OS), no consensus exists regarding the minimal nor optimal number of lymph nodes to resect at curative lung cancer surgery. METHODS: We studied subjects in the Surveillance Epidemiology and End Results Database (SEER) diagnosed with non-small cell lung cancer between 2000 and 2011 who underwent either lobectomy or pneumonectomy and had pathologic negative nodal evaluation...
March 15, 2017: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28299581/expression-of-anoctamin-1-is-associated-with-advanced-tumor-stage-in-patients-with-non-small-cell-lung-cancer-and-predicts-recurrence-after-surgery
#12
Y He, H Li, Y Chen, P Li, L Gao, Y Zheng, Y Sun, J Chen, X Qian
PURPOSE: Anoctamin 1 (ANO1), a recently identified calcium-activated chloride channel, has been found to have a critical role in tumorigenesis and tumor progression in several types of cancer. However, its role in non-small cell lung cancer (NSCLC) remains to be elucidated. In this study, we evaluated the utility of ANO1 as a prognostic marker. PATIENTS AND METHODS: ANO1 expression was detected in tumor tissues and paraneoplastic tissues of I-IV stage NSCLC patients who received surgical treatment by using immunohistochemical and quantitative RT-PCR analyses...
March 15, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28285692/chest-wall-resection-for-non-small-cell-lung-cancer-a-case-matched-study-of-postoperative-pulmonary-function-and-quality-of-life
#13
Ming Liu, Jason A Wampfler, Jie Dai, Ruchi Gupta, Zhiqiang Xue, Shawn M Stoddard, Stephen D Cassivi, Gening Jiang, Ping Yang
BACKGROUND: To assess the pulmonary function and quality of life (QOL) after chest wall resection for non-small cell lung cancer. MATERIAL AND METHODS: One hundred and thirty-five patients (cases) who underwent pulmonary resection with chest wall removal were identified from January 1997 to December 2015. Propensity score matching (1:3) was applied to balance known confounders for pulmonary function and QOL between the cases and the control group who underwent pulmonary resection without chest wall invasion...
April 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/28285463/video-assisted-thoracoscopic-surgery-node-dissection-for-lung-cancer-treatment
#14
REVIEW
Atsushi Watanabe, Masahiro Miyajima, Taijiro Mishina, Kodai Tsuruta, Yuki Takahashi, Ryunosuke Maki, Makoto Tada
PURPOSE: Mediastinal node dissection (MND) is an integral component of the surgical treatment for non-small cell lung cancer (NSCLC). Although video-assisted thoracoscopic surgery (VATS) has been used increasingly for lung cancer treatment, the accuracy of by VATS MND still remains controversial. We reviewed the surgical results of VATS MND for NSCLC. METHODS: A systematic review of literature was performed, and articles that fully described the surgical procedure, devices, and results of VATS MND were selected to compare the efficacy of MND by VATS and thoracotomy...
March 11, 2017: Surgery Today
https://www.readbyqxmd.com/read/28279919/active-targeting-theranostic-iron-oxide-nanoparticles-for-mri-and-magnetic-resonance-guided-focused-ultrasound-ablation-of-lung-cancer
#15
Zhongling Wang, Ruirui Qiao, Na Tang, Ziwei Lu, Han Wang, Zaixian Zhang, Xiangdong Xue, Zhongyi Huang, Siruo Zhang, Guixiang Zhang, Yuanpei Li
Despite its great promise in non-invasive treatment of cancers, magnetic resonance-guided focused ultrasound surgery (MRgFUS) is currently limited by the insensitivity of magnetic resonance imaging (MRI) for visualization of small tumors, low efficiency of in vivo ultrasonic energy deposition, and damage to surrounding tissues. We hereby report the development of an active targeting nano-sized theranostic superparamagnetic iron oxide (SPIO) platform for significantly increasing the imaging sensitivity and energy deposition efficiency using a clinical MRgFUS system...
March 1, 2017: Biomaterials
https://www.readbyqxmd.com/read/28278499/recurrence-and-risk-factors-for-relapse-in-patients-with-non-small-cell-lung-cancer-treated-by-surgery-with-curative-intent
#16
Cristiana Cruz, Margarida Afonso, Bárbara Oliveiros, Alice Pêgo
INTRODUCTION: Surgery remains the potentially curative treatment for early-stage non-small cell lung cancer (NSCLC). Despite this, tumor recurrence is the most common cause of treatment failure after surgery. METHODS: Data were collected retrospectively from clinical files of patients who underwent lung surgery for NSCLC from January 2008 to December 2012 in a University Hospital. Demographic data, tumor characteristics, type of surgery and recurrence were recorded...
March 10, 2017: Oncology
https://www.readbyqxmd.com/read/28275483/variations-in-positron-emission-tomography-computed-tomography-findings-for-patients-receiving-neoadjuvant-and-non-neoadjuvant-therapy-for-non-small-cell-lung-cancer
#17
Jae Kil Park, Jae Jun Kim, Seok Whan Moon
BACKGROUND: The aims of this study were to predict locoregional lymph node (LN) metastases using positron emission tomography-computed tomography (PET-CT) and investigate variations in PET-CT findings for patients receiving neoadjuvant (NT) and non-neoadjuvant (non-NT) for non-small cell lung cancer (NSCLC). METHODS: Data from 578 consecutive patients from January 2010 to December 2015 who met this study inclusion criteria were retrospectively reviewed. All patients underwent curative and complete resections for NSCLC in a Korean hospital...
February 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28275477/curative-resection-for-lung-cancer-in-octogenarians-is-justified
#18
Michaela Tutic-Horn, Franco Gambazzi, Gaetano Rocco, Monique Mosimann, Didier Schneiter, Isabelle Opitz, Nono Martucci, Sven Hillinger, Walter Weder, Wolfgang Jungraithmayr
BACKGROUND: Due to an increased life expectancy in a healthy aging population and a progressive incidence of lung cancer, curative pulmonary resections can be performed even in octogenarians. The present study aims to investigate whether surgery is justified in patients reaching the age of 80 years and older who undergo resection for non-small cell lung cancer (NSCLC). METHODS: In this retrospective multi-centre analysis, the morbidity, mortality and long-term survival of 88 patients (24 females) aged ≥80 who underwent complete resection for lung cancer between 2000 and 2013 were analysed...
February 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28275466/surgery-in-microscopically-pathological-n2-non-small-cell-lung-cancer-the-size-of-lymph-node-matters
#19
EDITORIAL
Ming-Ching Lee, Chung-Ping Hsu
No abstract text is available yet for this article.
February 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28275222/pd-1-pd-l1-protein-expression-in-non-small-cell-lung-cancer-and-their-relationship-with-tumor-infiltrating-lymphocytes
#20
Yayi He, Leslie Rozeboom, Christopher J Rivard, Kim Ellison, Rafał Dziadziuszko, Hui Yu, Caicun Zhou, Fred R Hirsch
BACKGROUND Immunotherapy targeting the programmed death-1 (PD-1)/programmed death ligand-1 (PD-L1) checkpoint has shown the good outcomes in non-small cell lung cancer (NSCLC). We investigated PD-1 and PD-L1 protein expression and their correlation with tumor-infiltrating lymphocytes (TILs), and association with survival in NSCLC. MATERIAL AND METHODS The expression of PD-1 (NAT105, Cell Marque) and PD-L1 (28-8, Dako) protein was assessed in 55 NSCLC cell lines by immunohistochemistry (IHC). PD-1 (NAT105, Cell Marque) and PD-L1 (22C3, Dako) protein expression was evaluated by IHC, and TIL percentage was scored, in 139 surgically resected specimens from patients with NSCLC...
March 9, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
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